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Conserved domains on  [gi|981220775|ref|NP_001306043|]
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nucleolus and neural progenitor protein isoform b [Homo sapiens]

Protein Classification

NEPRO family protein( domain architecture ID 144623)

nucleolus and neural progenitor protein (NEPRO) family protein is a DUF4477 domain-containing protein; similar to human NEPRO that may play a role in cortex development as part of the Notch signaling pathway

Gene Ontology:  GO:0045747

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RMP1_RBD super family cl20703
RNA binding domain of Saccharomyces cerevisiae RNase MRP protein 1 (RMP1) and similar proteins; ...
 1-66 7.25e-15

RNA binding domain of Saccharomyces cerevisiae RNase MRP protein 1 (RMP1) and similar proteins; RMP1, also called RNA-processing protein RMP1, or RNase MRP 23.6 kDa subunit, functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria. RNase MRP complex consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex. RMP1 is required for proper rRNA processing. The model corresponds to a conserved region of RMP1, which is responsible for the RNA binding.


The actual alignment was detected with superfamily member pfam14780:

Pssm-ID: 473480  Cd Length: 189  Bit Score: 72.65  E-value: 7.25e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 981220775    1 MKVLGACKLLLRLLDCCCKTFLLTVKHLGLQEFIILNLVMVGLVSRLWVLYKGVLKRLILLYEPLF 66
Cdd:pfam14780 124 VRLLGFAKLMLRILDCCKKAFLLSVQHLRLGEFIILNVVLLALISRLWVLSRGILKKLCSLYNKLF 189
 
Name Accession Description Interval E-value
DUF4477 pfam14780
Domain of unknown function (DUF4477);
1-66 7.25e-15

Domain of unknown function (DUF4477);


Pssm-ID: 464313  Cd Length: 189  Bit Score: 72.65  E-value: 7.25e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 981220775    1 MKVLGACKLLLRLLDCCCKTFLLTVKHLGLQEFIILNLVMVGLVSRLWVLYKGVLKRLILLYEPLF 66
Cdd:pfam14780 124 VRLLGFAKLMLRILDCCKKAFLLSVQHLRLGEFIILNVVLLALISRLWVLSRGILKKLCSLYNKLF 189
 
Name Accession Description Interval E-value
DUF4477 pfam14780
Domain of unknown function (DUF4477);
1-66 7.25e-15

Domain of unknown function (DUF4477);


Pssm-ID: 464313  Cd Length: 189  Bit Score: 72.65  E-value: 7.25e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 981220775    1 MKVLGACKLLLRLLDCCCKTFLLTVKHLGLQEFIILNLVMVGLVSRLWVLYKGVLKRLILLYEPLF 66
Cdd:pfam14780 124 VRLLGFAKLMLRILDCCKKAFLLSVQHLRLGEFIILNVVLLALISRLWVLSRGILKKLCSLYNKLF 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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