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Conserved domains on  [gi|978205926|gb|KVL06743|]
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universal stress protein UspA [Burkholderia cepacia]

Protein Classification

universal stress protein( domain architecture ID 10001747)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

CATH:  3.40.50.620
Gene Ontology:  GO:0042802
PubMed:  23745136|9405142|12732303
SCOP:  8083864

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-142 1.13e-38

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


:

Pssm-ID: 440354  Cd Length: 136  Bit Score: 127.34  E-value: 1.13e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   1 MFRHILVPTDGSELSQKAIDGAIDLARAVGARVTAYACLPQYPYSPFSeviiepPADFRARSEREARAHLDEVESAAKAA 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAG------PEELEEELREEAEEALEEAAERLEEA 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 978205926  81 GVDCDTWTsVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIV 142
Cdd:COG0589   75 GVEVETVV-REGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-142 1.13e-38

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 127.34  E-value: 1.13e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   1 MFRHILVPTDGSELSQKAIDGAIDLARAVGARVTAYACLPQYPYSPFSeviiepPADFRARSEREARAHLDEVESAAKAA 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAG------PEELEEELREEAEEALEEAAERLEEA 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 978205926  81 GVDCDTWTsVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIV 142
Cdd:COG0589   75 GVEVETVV-REGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-144 6.08e-30

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 105.18  E-value: 6.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926    5 ILVPTDGSELSQKAIDGAIDLARAVGARVTAYACLPQYPYSPFSEVIIEPPADFRARSEREARAhldEVESAAKAAGVDC 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEA---LAAAAAAEAGGVK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   85 DTWTSVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIVYR 144
Cdd:pfam00582  78 VEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 4-142 2.05e-29

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 103.97  E-value: 2.05e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   4 HILVPTDGSELSQKAIDGAIDLARAVGARVTAYACLPQYPYSPFSEVIIEppadFRARSEREARAHLDEVESAAKAAGVD 83
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEE----LADELKEEAEELLEEAKKLAEEAGVE 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 978205926  84 CDTWTsVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIV 142
Cdd:cd00293   77 VETIV-VEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
PRK15005 PRK15005
universal stress protein UspF;
1-144 1.43e-08

universal stress protein UspF;


Pssm-ID: 184967 [Multi-domain]  Cd Length: 144  Bit Score: 50.19  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   1 MFRHILVPTD--GSELSQKAIDGAIDLARAVGARVTAYACLPQYPYspFSEVIIEPPADFRARSEREARAhLDEVESAAK 78
Cdd:PRK15005   1 MNRTILVPIDisDSELTQRVISHVEAEAKIDDAEVHFLTVIPSLPY--YASLGLAYSAELPAMDDLKAEA-KSQLEEIIK 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 978205926  79 AAGVDCDTWTS--VHPSPYLGIIEAAERGGCDVIFMASHgRRGLGSLLIGSETQRVLTHTKIPVIVYR 144
Cdd:PRK15005  78 KFKLPTDRVHVhvEEGSPKDRILELAKKIPADMIIIASH-RPDITTYLLGSNAAAVVRHAECSVLVVR 144
 
Name Accession Description Interval E-value
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
1-142 1.13e-38

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 127.34  E-value: 1.13e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   1 MFRHILVPTDGSELSQKAIDGAIDLARAVGARVTAYACLPQYPYSPFSeviiepPADFRARSEREARAHLDEVESAAKAA 80
Cdd:COG0589    1 MYKRILVPTDGSEEAERALEYAAELAKALGAELHLLHVVDPPPSAAAG------PEELEEELREEAEEALEEAAERLEEA 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 978205926  81 GVDCDTWTsVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIV 142
Cdd:COG0589   75 GVEVETVV-REGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 5-144 6.08e-30

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 105.18  E-value: 6.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926    5 ILVPTDGSELSQKAIDGAIDLARAVGARVTAYACLPQYPYSPFSEVIIEPPADFRARSEREARAhldEVESAAKAAGVDC 84
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEA---LAAAAAAEAGGVK 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   85 DTWTSVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIVYR 144
Cdd:pfam00582  78 VEVVVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 4-142 2.05e-29

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 103.97  E-value: 2.05e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   4 HILVPTDGSELSQKAIDGAIDLARAVGARVTAYACLPQYPYSPFSEVIIEppadFRARSEREARAHLDEVESAAKAAGVD 83
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEE----LADELKEEAEELLEEAKKLAEEAGVE 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 978205926  84 CDTWTsVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIV 142
Cdd:cd00293   77 VETIV-VEGDPAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLV 134
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 3-144 1.93e-16

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 70.73  E-value: 1.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   3 RHILVPTDGSELSQKAIDGAIDLARAVGARVTAYACLPQYPYSPFS-EVIIEPPADFRARSEREARAHLDEVESAAKAA- 80
Cdd:cd23659    1 RKVLIAVDGSEESEYALEWALENLHRPGDEVVLLHVIEPPSLPAASlGSGSEEWEALEEEAREKAEKLLEKYEKKLKEEk 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 978205926  81 GVDCDTWTsVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIVYR 144
Cdd:cd23659   81 GIKVKVEV-VAGDPGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVLVVR 143
USP_Rv2623_repeat2 cd23661
universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis ...
 5-144 4.12e-11

universal stress protein Rv2623 and similar proteins, USP repeat 2; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition, Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467507 [Multi-domain]  Cd Length: 133  Bit Score: 56.75  E-value: 4.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   5 ILVPTDGSELSQKAIDGAIDLARAVGARVTAYACLPQYPYSPFseviiePPADFRARSEREARA-------HLDEVESAA 77
Cdd:cd23661    2 VVVGVDGSPASELATEIAFDEASRRGVDLVALHAWSDMGPGGF------LGIDWRESEQDQERMlaerlagWQERYPDVH 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 978205926  78 KAAGVDCDtwtsvHPSPYLgiIEAAERGgcDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIVYR 144
Cdd:cd23661   76 VHKVVVRD-----RPARVL--LEASERA--QLVVVGSHGRGGFAGMLLGSVSRAVLHSAPCPVIVVR 133
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 2-144 1.09e-09

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 53.08  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   2 FRHILVPTDGSELSQKAIDGAIDLARAVGARVTAYACLPQYP--YSPFSEVIIEPPADFRARSEREARAHLDEVesaaka 79
Cdd:cd23657    1 YKHILVAVDLSPESQSLVDKAVEIARENDAKLSLIHVDEDISeyYTGLIDVDIAALQDLESTMLEEALKNLSEL------ 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 978205926  80 AGVDCD-TWTSVHPSPYLgIIEAAERGGCDVIFMASHGRRGLGslLIGSETQRVLTHTKIPVIVYR 144
Cdd:cd23657   75 AGYPVDhTFIGYGDLKEE-ILEVAKKHNVDLIVCGHHGDFGLS--LLGSSARAVLNSAPCDVLIVP 137
PRK15005 PRK15005
universal stress protein UspF;
1-144 1.43e-08

universal stress protein UspF;


Pssm-ID: 184967 [Multi-domain]  Cd Length: 144  Bit Score: 50.19  E-value: 1.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   1 MFRHILVPTD--GSELSQKAIDGAIDLARAVGARVTAYACLPQYPYspFSEVIIEPPADFRARSEREARAhLDEVESAAK 78
Cdd:PRK15005   1 MNRTILVPIDisDSELTQRVISHVEAEAKIDDAEVHFLTVIPSLPY--YASLGLAYSAELPAMDDLKAEA-KSQLEEIIK 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 978205926  79 AAGVDCDTWTS--VHPSPYLGIIEAAERGGCDVIFMASHgRRGLGSLLIGSETQRVLTHTKIPVIVYR 144
Cdd:PRK15005  78 KFKLPTDRVHVhvEEGSPKDRILELAKKIPADMIIIASH-RPDITTYLLGSNAAAVVRHAECSVLVVR 144
PRK11175 PRK11175
universal stress protein UspE; Provisional
 1-124 8.38e-06

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 43.71  E-value: 8.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   1 MFRHILVPTDGSELSQKAIDGAIDLARAVGARVTAYacLPQYPYSPFSEVIIEPpadfrarSEREA---------RAHLD 71
Cdd:PRK11175   2 KYQNILVVIDPNQDDQPALRRAVYLAQRNGGKITAF--LPIYDFSYEMTTLLSP-------DEREAmrqgvisqrTAWIR 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 978205926  72 EVESAAKAAGVDCDT---WtsvHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLL 124
Cdd:PRK11175  73 EQAKPYLDAGIPIEIkvvW---HNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVI 125
USP-E_repeat1 cd23943
Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP ...
 2-144 7.61e-05

Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467508  Cd Length: 143  Bit Score: 40.23  E-value: 7.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   2 FRHILVPTDGSELSQKAIDGAIDLARAVGARVTAYacLPQYPYSPFSEVIIEPP--ADFRARSEREARAHLDEVESAAKA 79
Cdd:cd23943    1 YQNMLVVIDPNQDDQPALRRAVYLVQRIGGKIKAF--LPIYDLSYEMTTLLSPDerTAMRQGVISQRTAWIREQAKYYLE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 978205926  80 AGVDCDTWTSVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIVYR 144
Cdd:cd23943   79 AGIPIEIKVVWHNRPFEAIIQEVIAGNHDLVLKMAHQHDRLESLIFTPTDWHLLRKCPSPVWMVK 143
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 2-142 1.39e-04

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 39.56  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   2 FRHILVPTDGS-------ELSQKAIDGAIDLARAVGARVTAYAClpqYPYSPFSEVIIEPPADFRARSEREARAHLDEVE 74
Cdd:cd23660    1 GGRILVAVDPSneeeyheDLNLRLIELAYSLAAQLKAELHLVSA---WPVTPENIAIELPEFDPTEYVDAIRGRHLEAMK 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 978205926  75 SAAKAAGVDCDTWTSVHPSPYLGIIEAAERGGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIV 142
Cdd:cd23660   78 ALRQKFGIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDLLA 145
USP_Rv2623_repeat1 cd23944
universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis ...
 5-144 5.83e-03

universal stress protein Rv2623 and similar proteins, USP repeat 1; Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth in vitro and in vivo and is required for the entry of the tubercle bacillus into the chronic phase of infection in the host. In addition Rv2623 binds ATP and the growth-regulatory attribute of this USP is dependent on its ATP-binding activity. Rv2623 is thought to function as an ATP-dependent signaling intermediate in a pathway that promotes persistent infection. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although Usp lacks ATP-binding activity.


Pssm-ID: 467509  Cd Length: 140  Bit Score: 35.07  E-value: 5.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 978205926   5 ILVPTDGSELSQKAIDGAIDLA--RAVGARVtayacLPQYPYSPFSEVIIEPPADFRARSEREARAHLDEVESAAKAAGV 82
Cdd:cd23944    2 IIVGVDGSPASDAAVRWAAREAqlRQIPLTL-----VHVVPPVVVSWPEGPRPAEVLDWQQDEARQVIEQARKVAEEASG 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 978205926  83 DCD----TWTSVHPSPYLGIIEAAErgGCDVIFMASHGRRGLGSLLIGSETQRVLTHTKIPVIVYR 144
Cdd:cd23944   77 EGPpvkvETEIVPGSPVPTLVEASR--DATMVVVGSRGIGALAGLLLGSVSTSLVRHAHCPVAVIH 140
USP_NhaS5_C cd01988
C-terminal USP domain(s) of Na(+)/H(+) antiporter NhaS5 and similar proteins; Na(+)/H(+) ...
 108-144 8.36e-03

C-terminal USP domain(s) of Na(+)/H(+) antiporter NhaS5 and similar proteins; Na(+)/H(+) exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolizing cells. Na(+)/H(+) exchange activity is also crucial for the regulation of cell volume, and for the reabsorption of NaCl across renal, intestinal, and other epithelia. These antiporters exchange Na(+) for H(+) in an electroneutral manner, and this activity is carried out by a family of Na(+)/H(+) exchangers, or NHEs, which are known to be present in both prokaryotic and eukaryotic cells. These exchangers are highly-regulated (glyco)phosphoproteins, which, based on their primary structure, appear to contain 10-12 membrane-spanning regions (M) at the N-terminus and a large cytoplasmic region at the C-terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. This is thought to be the region that is involved in the transport of sodium and hydrogen ions. The C-terminal region contains one or two domains that show homology with universal stress protein (USP), a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467492  Cd Length: 125  Bit Score: 34.40  E-value: 8.36e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 978205926 108 DVIFMASHgRRGLGSLLIGSETQRVLTHTKIPVIVYR 144
Cdd:cd01988   90 DLIVMGWR-RTFLGNVLLGSTIDKVLMKAPTDVAVTR 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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