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Conserved domains on  [gi|975892845|gb|AMA12769|]
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polyprotein, partial [Hepacivirus hominis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HCV_NS1 super family cl03263
Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region ...
 64-176 1.76e-71

Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein.


The actual alignment was detected with superfamily member pfam01560:

Pssm-ID: 110557  Cd Length: 344  Bit Score: 219.34  E-value: 1.76e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975892845   64 HVSGGSAGYTTRGLTSIFSPGPSQKLQLVNTNGSWHINRTALNCNDSLQTGFIAALFYARKLNLSGCSERMASCRSIDKF 143
Cdd:pfam01560   1 HVTGGSAARTTRGLVSLFSPGAKQNIQLINTNGSWHINRTALNCNDSLQTGFLASLFYTHRFNSSGCPERLASCRSIDDF 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 975892845  144 DQGWGPITYTTPNSSDQRPYCWHYAPRPCGIVP 176
Cdd:pfam01560  81 RQGWGPITYEETNPEDQRPYCWHYPPRPCGIVP 113
HCV_env super family cl03255
Hepatitis C virus envelope glycoprotein E1;
1-60 3.38e-31

Hepatitis C virus envelope glycoprotein E1;


The actual alignment was detected with superfamily member pfam01539:

Pssm-ID: 110536  Cd Length: 190  Bit Score: 111.51  E-value: 3.38e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 975892845    1 MMNWSPTTALVVSQLLRIPQAIVDMVVGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVD 60
Cdd:pfam01539 131 MMNWSPTATMILAYALRVPEAVLDIIAGAHWGVLFGLAYFSMQGAWAKVLVILLLFAGVD 190
 
Name Accession Description Interval E-value
HCV_NS1 pfam01560
Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region ...
 64-176 1.76e-71

Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein.


Pssm-ID: 110557  Cd Length: 344  Bit Score: 219.34  E-value: 1.76e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975892845   64 HVSGGSAGYTTRGLTSIFSPGPSQKLQLVNTNGSWHINRTALNCNDSLQTGFIAALFYARKLNLSGCSERMASCRSIDKF 143
Cdd:pfam01560   1 HVTGGSAARTTRGLVSLFSPGAKQNIQLINTNGSWHINRTALNCNDSLQTGFLASLFYTHRFNSSGCPERLASCRSIDDF 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 975892845  144 DQGWGPITYTTPNSSDQRPYCWHYAPRPCGIVP 176
Cdd:pfam01560  81 RQGWGPITYEETNPEDQRPYCWHYPPRPCGIVP 113
HCV_env pfam01539
Hepatitis C virus envelope glycoprotein E1;
1-60 3.38e-31

Hepatitis C virus envelope glycoprotein E1;


Pssm-ID: 110536  Cd Length: 190  Bit Score: 111.51  E-value: 3.38e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 975892845    1 MMNWSPTTALVVSQLLRIPQAIVDMVVGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVD 60
Cdd:pfam01539 131 MMNWSPTATMILAYALRVPEAVLDIIAGAHWGVLFGLAYFSMQGAWAKVLVILLLFAGVD 190
 
Name Accession Description Interval E-value
HCV_NS1 pfam01560
Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region ...
 64-176 1.76e-71

Hepatitis C virus non-structural protein E2/NS1; The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein.


Pssm-ID: 110557  Cd Length: 344  Bit Score: 219.34  E-value: 1.76e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975892845   64 HVSGGSAGYTTRGLTSIFSPGPSQKLQLVNTNGSWHINRTALNCNDSLQTGFIAALFYARKLNLSGCSERMASCRSIDKF 143
Cdd:pfam01560   1 HVTGGSAARTTRGLVSLFSPGAKQNIQLINTNGSWHINRTALNCNDSLQTGFLASLFYTHRFNSSGCPERLASCRSIDDF 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 975892845  144 DQGWGPITYTTPNSSDQRPYCWHYAPRPCGIVP 176
Cdd:pfam01560  81 RQGWGPITYEETNPEDQRPYCWHYPPRPCGIVP 113
HCV_env pfam01539
Hepatitis C virus envelope glycoprotein E1;
1-60 3.38e-31

Hepatitis C virus envelope glycoprotein E1;


Pssm-ID: 110536  Cd Length: 190  Bit Score: 111.51  E-value: 3.38e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 975892845    1 MMNWSPTTALVVSQLLRIPQAIVDMVVGAHWGVLAGLAYYSMVGNWAKVLIVMLLFAGVD 60
Cdd:pfam01539 131 MMNWSPTATMILAYALRVPEAVLDIIAGAHWGVLFGLAYFSMQGAWAKVLVILLLFAGVD 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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