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Conserved domains on  [gi|975826459|emb|CUX93049|]
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MarR family transcriptional regulator [Bacillus velezensis]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
8-135 2.63e-13

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 62.68  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975826459   8 RLNDLWTDIYYRLRYQHHEK-----ITHQGVRILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKTRSVED 82
Cdd:COG1846   11 RLGLLLRRLARALRRALDRAlaelgLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPED 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 975826459  83 ERKVILKLTSLGADVLYRHSGLDEEKLKQlLFDNMNNEERTLVLKAFSLMKER 135
Cdd:COG1846   91 RRAVLVRLTEKGRALLEEARPALEALLAE-LLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
8-135 2.63e-13

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 62.68  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975826459   8 RLNDLWTDIYYRLRYQHHEK-----ITHQGVRILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKTRSVED 82
Cdd:COG1846   11 RLGLLLRRLARALRRALDRAlaelgLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPED 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 975826459  83 ERKVILKLTSLGADVLYRHSGLDEEKLKQlLFDNMNNEERTLVLKAFSLMKER 135
Cdd:COG1846   91 RRAVLVRLTEKGRALLEEARPALEALLAE-LLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-122 2.43e-11

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 56.45  E-value: 2.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975826459    26 EKITHQGVRILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKTRSVEDERKVILKLTSLGADVlyrHSGLD 105
Cdd:smart00347   6 LGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGREL---IEQLL 82

                           90
                   ....*....|....*....
gi 975826459   106 EEKLKQL--LFDNMNNEER 122
Cdd:smart00347  83 EARSETLaeLLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-84 9.07e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 43.35  E-value: 9.07e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 975826459   33 VRILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKTRSVEDER 84
Cdd:pfam12802   8 FRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 33-92 3.50e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.89  E-value: 3.50e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 975826459  33 VRILQVIQkEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVyktRSVEDERKVILKLTS 92
Cdd:cd00090   10 LRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLV---ESRREGRRVYYSLTD 65
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 26-90 7.58e-04

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 37.72  E-value: 7.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 975826459   26 EKITHQGVRILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKtRSVEDERKVILKL 90
Cdd:TIGR01884 139 AGLSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ-KGRKGKRYSLTKL 202
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
8-135 2.63e-13

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 62.68  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975826459   8 RLNDLWTDIYYRLRYQHHEK-----ITHQGVRILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKTRSVED 82
Cdd:COG1846   11 RLGLLLRRLARALRRALDRAlaelgLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPED 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 975826459  83 ERKVILKLTSLGADVLYRHSGLDEEKLKQlLFDNMNNEERTLVLKAFSLMKER 135
Cdd:COG1846   91 RRAVLVRLTEKGRALLEEARPALEALLAE-LLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-122 2.43e-11

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 56.45  E-value: 2.43e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975826459    26 EKITHQGVRILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKTRSVEDERKVILKLTSLGADVlyrHSGLD 105
Cdd:smart00347   6 LGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGREL---IEQLL 82

                           90
                   ....*....|....*....
gi 975826459   106 EEKLKQL--LFDNMNNEER 122
Cdd:smart00347  83 EARSETLaeLLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-84 9.07e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 43.35  E-value: 9.07e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 975826459   33 VRILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKTRSVEDER 84
Cdd:pfam12802   8 FRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 28-86 1.50e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 42.92  E-value: 1.50e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 975826459   28 ITHQGVRILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKTRSVEDERKV 86
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 33-92 3.50e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.89  E-value: 3.50e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 975826459  33 VRILQVIQkEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVyktRSVEDERKVILKLTS 92
Cdd:cd00090   10 LRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLV---ESRREGRRVYYSLTD 65
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
34-74 7.34e-04

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 35.49  E-value: 7.34e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 975826459   34 RILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYV 74
Cdd:pfam13412   5 KILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
 26-90 7.58e-04

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 37.72  E-value: 7.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 975826459   26 EKITHQGVRILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKtRSVEDERKVILKL 90
Cdd:TIGR01884 139 AGLSREELKILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVEQ-KGRKGKRYSLTKL 202
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
35-101 1.17e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 36.72  E-value: 1.17e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 975826459  35 ILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKtrsvEDERKVilKLTSLG----ADVLYRH 101
Cdd:COG1321   15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEY----EPYGGI--TLTEEGrelaLRIVRRH 79
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
34-68 1.33e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 37.21  E-value: 1.33e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 975826459  34 RILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRL 68
Cdd:COG2345   17 RILELLKRAGPVTAAELAEALGLTPNAVRRHLDAL 51
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 35-91 3.85e-03

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 34.92  E-value: 3.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 975826459   35 ILQVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYVYKTRSVEDERKVILKLT 91
Cdd:TIGR01889  34 LGKLENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSEDDERKVIISIN 90
MJ0558 COG1497
Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain [Transcription];
34-101 6.41e-03

Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain [Transcription];


Pssm-ID: 441106  Cd Length: 261  Bit Score: 35.21  E-value: 6.41e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 975826459  34 RIL-QVIQKEKAVGIKDIAEAIQVSHNTASEHIKRLLKKKYvyktrsVEDERKVILKLTSLGADVLYRH 101
Cdd:COG1497   14 QILvEIAERQPAVRQGEIADKLGVTPQAVSEYIKELVEEGL------VEKEGRGRYRVTKEGVEWLLEN 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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