|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
5-1075 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 1678.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 5 VAE--NINFPEEEEKILQFWNRLDCFQECLKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERR 82
Cdd:PLN02882 2 VCEgkDFSFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 83 FGWDCHGLPVEYEIDKMLGIKGPEDVAKMGIAEYNNNCRGIVMRYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWV 162
Cdd:PLN02882 82 FGWDCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 163 FKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVIVSFPL-EEDESISLVAWTTTPWTLPSNLALCVNPE 241
Cdd:PLN02882 162 FKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLNYKDVSDPAVMVSFPIvGDPDNASFVAWTTTPWTLPSNLALCVNPN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 242 LQYVKVKDKNIGKIFILMEARLISLY----KSEK---------EYSVLDRFPGISLKGKKYKPLFEYFIKCKENgAFTVV 308
Cdd:PLN02882 242 FTYVKVRNKYTGKVYIVAESRLSALPtakpKSKKgskpenaaeGYEVLAKVPGSSLVGKKYEPLFDYFSEFSDT-AFRVV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 309 TDNYVKEEEGTGVVHQAPYFGADDYRVCMDFNIIQKDSVPVCPVDASGCFTAEVTDFAGQYVKDADKNIIKALKERGRLI 388
Cdd:PLN02882 321 ADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIIEKGGNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLV 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 389 HISSFKHSYPFCWRSETPLIYKAVPSWFVRVEHMVDRLLENNAQCYWVPDFVREKRFGNWLRDARDWAISRNRYWGTPIP 468
Cdd:PLN02882 401 KSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRSRFWGTPLP 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 469 LWVSDDFEEVVCIGSVAELEELSGVKVTDLHRESVDQVTVPSRCGK--GVLHRISEVFDCWFESGSMPYAQVHYPFENKK 546
Cdd:PLN02882 481 IWISDDGEEVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSRGPefGVLRRVDDVFDCWFESGSMPYAYIHYPFENKE 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 547 EFEDA*PADFIAEGIDQPRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVNIVNSYGADALRLY 626
Cdd:PLN02882 561 LFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLY 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 627 LINSPVVRAENLRFKEEGVRDVLKDVFLPWYNAYRFLIQNVVILQLKEEGKEFLYNENTVKENNNIMDKWILSFTQSLIQ 706
Cdd:PLN02882 641 LINSPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLVQNAKRLEVEGGAPFVPLDLAKLQNSANVLDRWINSATQSLVK 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 707 FFRAEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGTDDCIMALETLFSVLFSMCRLMAPYTPFITELMYQNLK 786
Cdd:PLN02882 721 FVREEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLR 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 787 TLIDPASvqekntDSIHYLMLPQAREDLIDKNIESAVSRMQSVIELGRVIRDRKTIPVKYPLKEVVVIHHDPQVLEVIR- 865
Cdd:PLN02882 801 KVLPGSE------ESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFLDDITg 874
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 866 SLEKYILEELNVRQVTLSTDKDKYgIRLRAEPDHMVLGKRLKGAFKSVMTAIKELTSEQLEEFQKTGTIVVEGHELHEED 945
Cdd:PLN02882 875 KLKEYVLEELNVRSLVPCNDPLKY-ASLRAEPNFSVLGKRLGKSMGLVAKEVKAMSQDDILEFEKAGEVTIAGHTLKAGD 953
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 946 LRLMYTFDQAVGGSA-HFEAHSDSQVLVLLDVTPDQSMVDEGVAREVINRIQKLRKKRNLVPTDEITVYYRAHPEGD--Y 1022
Cdd:PLN02882 954 IKVVRDFKRPEGVSKeDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEVFFESLDEVDesA 1033
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....*
gi 975090365 1023 LDTVIKEHTDFIFATIKADLKAYPLPPSTEVLIQEKTQLKGSELE--ISLAKGTL 1075
Cdd:PLN02882 1034 LSQVLKSQAQYIRESLGSPLLPSSMMPSHAVVIAEESFHGVSGLSfkISLARPAL 1088
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
5-1071 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 1133.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 5 VAENINFPEEEEKILQFWNRLDCFQECLKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFG 84
Cdd:PTZ00427 68 VSENPNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 85 WDCHGLPVEYEIDKMLGIKGPEDVAKMGIAEYNNNCRGIVMRYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFK 164
Cdd:PTZ00427 148 WDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFS 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 165 QLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVIVSF-------------PLEEDESI------------- 218
Cdd:PTZ00427 228 ELYKNNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISFvlcsdfpkveeecNIEEDKQLlgekysvlynnkr 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 219 --------------------SLVAWTTTPWTLPSNLALCVNPELQYVKVKDKNIGKIFILMEARLISLYKSEK----EYS 274
Cdd:PTZ00427 308 ensnngnnnstnnvcyaqhsEILAWTTTPWTLPSNLALCVNEHFTYLRIHHVKSNRVVIVGECRLEWIMKELKwnveDLK 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 275 VLDRFPGISLKGKKYKPLFEYFIKcKEN---GAFTVVTDNYVKEEEGTGVVHQAPYFGADDYRVCMDFNIIQKDS-VPVC 350
Cdd:PTZ00427 388 IVNRFKGKELKGLRYKPLFTNFYE-KYNfkeRAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIDPEKnIFID 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 351 PVDASGCFTAEVTDFAGQYVKDADKNIIKALKERGRLIHISSFKHSYPFCWRSETPLIYKAVPSWFVRVEHMVDRLLENN 430
Cdd:PTZ00427 467 PLDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNN 546
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 431 AQCYWVPDFVREKRFGNWLRDARDWAISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGVK-VTDLHRESVDQVTVP 509
Cdd:PTZ00427 547 ETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKHLEELSGVKnINDLHRHFIDHIEIK 626
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 510 SRCGKGV--LHRISEVFDCWFESGSMPYAQVHYPFENKKE-FEDA*PADFIAEGIDQPRGWFYTLLVLSTALFGKPPFKN 586
Cdd:PTZ00427 627 NPKGKTYpkLKRIPEVFDCWFESGSMPYAKVHYPFSTEKEdFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKN 706
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 587 VIVNGLVLASDGQKMSKRKKNYPDPVNIVNSYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVFLPWYNAYRFLIQN 666
Cdd:PTZ00427 707 LICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQEKGVNEVVKSFILPFYHSFRFFSQE 786
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 667 VVILQLKEEgKEFLYNENTVKENNNIMDKWILSFTQSLIQFFRAEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGE 746
Cdd:PTZ00427 787 VTRYECLNK-KQFLFNTDYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRMRGS 865
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 747 NGTDDCIMALETLFSVLFSMCRLMAPYTPFITELMYQNLKTLIDPASVQEKNT---------------DSIHYLMLPQAR 811
Cdd:PTZ00427 866 LGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRRVKSTNEHNENNEtgntkegdlnrgvihKSVHFIMLPQVD 945
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 812 ED-LIDKNIESAVSRMQSVIELGRVIRDRKTIPVKYPLKEVVVIHHDPQVLEVIRSLEKYILEELNVRQVTLSTDKDkyG 890
Cdd:PTZ00427 946 EKyIIDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFDQISNYIKEELNVLNVECSNDTS--C 1023
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 891 IRLRAEPDHMVLGKRLKGAFKSVMTAIKELTSEQLEEFQKTGTIVVEGHELHEEDL--RLMYTFDqavggSAHFEAHSDS 968
Cdd:PTZ00427 1024 LDFSAIPNYKTLGVKLGYNLKKVQNKIKNMDSESIKLYQQEGKITLDNVTLEGDDIiiQMKPNFQ-----NDNTDIISNN 1098
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 969 QVLVLLDVTPDQSMVDEGVAREVINRIQKLRKkrNLVPTDEITVYYRAHPEGDYLDTVIKEHTDFIFATIKADLKAYPLP 1048
Cdd:PTZ00427 1099 YVTILMDFTTDQQLENMASARELCNHIQKMRK--NLSLNQNSPVKMHVYIADDTLRNNMVSEMEYIKKCLRRELNVIPSQ 1176
|
1130 1140
....*....|....*....|....*..
gi 975090365 1049 PSTEVLI----QEKTQLKGSELEISLA 1071
Cdd:PTZ00427 1177 EDYQNLAdkmhDEEITLAGKPVRVVFA 1203
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
10-998 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1050.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 10 NFPEEEEKILQFWNRLDCFQECLKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHG 89
Cdd:COG0060 17 NLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDCHG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 90 LPVEYEIDKMLGIKGPeDVAKMGIAEYNNNCRGIVMRYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFKQLYDK 169
Cdd:COG0060 97 LPIELKVEKELGIKKK-DIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEK 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 170 GLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVIVSFPLEED------ESISLVAWTTTPWTLPSNLALCVNPELQ 243
Cdd:COG0060 176 GLLYKGLKPVPWCPRCGTALAEAEV--EYKDVTSPSIYVKFPVKDEkallllEDAYLVIWTTTPWTLPANLAVAVHPDID 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 244 YVKVKDKNiGKIFILMEARLISLYK--SEKEYSVLDRFPGISLKGKKYKPLFEYFIkcKENGAFTVVTDNYVKEEEGTGV 321
Cdd:COG0060 254 YVLVEVTG-GERLILAEALVEAVLKelGIEDYEVLATFKGAELEGLRYEHPFYYVV--GYDRAHPVILGDYVTTEDGTGI 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 322 VHQAPYFGADDYRVCMDFNIiqkdsVPVCPVDASGCFTAEVTDFAGQYVKDADKNIIKALKERGRLIHISSFKHSYPFCW 401
Cdd:COG0060 331 VHTAPGHGEDDFEVGKKYGL-----PVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCW 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 402 RSETPLIYKAVPSWFVRVEHMVDRLLENNAQCYWVPDFvREKRFGNWLRDARDWAISRNRYWGTPIPLWVSDDFEEVV-- 479
Cdd:COG0060 406 RCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCGELHrt 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 480 --CIGSVAELEELSGVKV---TDLHRESVDQVTVPSRCGkGVLHRISEVFDCWFESGSMPYAQVhypfENKKEFedA*PA 554
Cdd:COG0060 485 eeVIGSVAELLEEEGADAwfeLDLHRPFLDETLKCPKCG-GTMRRVPDVLDVWFDSGSMHFAVL----ENREEL--HFPA 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 555 DFIAEGIDQPRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVNIVNSYGADALRLYLINSPvvR 634
Cdd:COG0060 558 DFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWVASSD--Y 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 635 AENLRFKEEGVRDVlKDVFLPWYNAYRFLIQNVvilqlkeegKEFLYNENTV-KENNNIMDKWILSFTQSLIQFFRAEMA 713
Cdd:COG0060 636 WGDLRFSDEILKEV-RDVYRRLRNTYRFLLANL---------DDFDPAEDAVpYEDLPELDRWILSRLNELIKEVTEAYD 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 714 AYRLYTVVPRLVKFVDI-LTNWYVRMNRRRL-KGENGTDDCIMALETLFSVLFSMCRLMAPYTPFITELMYQNLKtlidp 791
Cdd:COG0060 706 NYDFHRAYRALHNFCVEdLSNWYLDISKDRLyTEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLP----- 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 792 asvqEKNTDSIHYLMLPQAREDLIDKNIESAVSRMQSVIELGR----VIRDRKTIpvKYPLKEVVVIHHDPQVLEVIRSL 867
Cdd:COG0060 781 ----GEAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEKLI--RQPLEAAVVLYADEELAAALESL 854
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 868 EKYILEELNVRQVTLSTDKDKYGirlraepdhmvlgkrlKGAFKSvmtaikeltseqLEEFQKTGTIVVEGHElHEEDLR 947
Cdd:COG0060 855 GDLLAEELNVSEVELVDDAEDLG----------------KDALKA------------LDVEGISVTVEVEKAD-GEKCER 905
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|.
gi 975090365 948 lmytfdqavggSAHFEahsdsqvlvlLDVTPDQsmvdEGVAREVINRIQKL 998
Cdd:COG0060 906 -----------CWHYE----------VGWTPEH----EGLCRRCVRRVQGL 931
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
10-864 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 967.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 10 NFPEEEEKILQFWNRLDCFQECLKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHG 89
Cdd:TIGR00392 7 NLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTHG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 90 LPVEYEIDKMLGIKGPEDVAKMGIAEYNNNCRGIVMRYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFKQLYDK 169
Cdd:TIGR00392 87 LPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEAHEK 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 170 GLVYRGVKVMPFSTACNTPLSNFESHQ--NYKDVQDPSVIVSFPLEEDE-------SISLVAWTTTPWTLPSNLALCVNP 240
Cdd:TIGR00392 167 GLLYRGLKPVYWSPRCRTALAEAEVEYkeNYKDVKDPSIYVKFPVKKDKktylkvkLSSLLIWTTTPWTLPSNLAIAVHP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 241 ELQYVKVKDKNIGKIFILMEARLISLYKSEKE-YSVLDRFPGISLKGKKYKPLFEYFIKCKENGAFTVVTDNYVKEEEGT 319
Cdd:TIGR00392 247 DFEYALVQDNTKVEYFILAKKLVEKLYNKAGSdYEIIKTFKGSDLEGLEYEHPLYDFVSQLKEGAPVVIGGDHVTTEDGT 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 320 GVVHQAPYFGADDYRVCmdfniiQKDSVPV-CPVDASGCFTAEVTDFAGQYVKDADKNIIKA-------LKERGRLIHIS 391
Cdd:TIGR00392 327 GIVHTAPGHGEEDYEIG------KKYGLEVlSPVDEKGVYTEGVNDFQGRFVKDADKDIIKAnkiiieqLKDKGLLLKAE 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 392 SFKHSYPFCWRSETPLIYKAVPSWFVRVEHMVDRLLENNAQCYWVPDFVrEKRFGNWLRDARDWAISRNRYWGTPIPLWV 471
Cdd:TIGR00392 401 KITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWG-EGRFGNWLENRPDWCISRQRYWGIPIPIWY 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 472 SDDFEEVVCIGSVAELEELSGVK-----VTDLHRESVDQVTVPSRCGkGVLHRISEVFDCWFESGSMPYAQVHYPFENKK 546
Cdd:TIGR00392 480 CEDTGEPIVVGSIEELIELIELKgidawFEDLHRDFLDKITLKSGDG-GEYRRVPDVLDVWFDSGSMPYASIHYPFENEK 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 547 EFEdA*PADFIAEGIDQPRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVNIVNSYGADALRLY 626
Cdd:TIGR00392 559 FKE-VFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRLY 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 627 LINSpvVRAENLRFKEEGVRDVLKDVFLPWYNAYRFLIQNVVILQLKEEGKEFLYnentvkENNNIMDKWILSFTQSLIQ 706
Cdd:TIGR00392 638 VASS--DPWEDLRFSDEILKQVVEKYRKIRWNTYRFLLTYANLDKFDPLFNSVAV------EKFPEEDRWILSRLNSLVE 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 707 FFRAEMAAYRLYTVVPRLVKFVDI-LTNWYVRMNRRRLKGENGTDDCIMALETLFSVLFSMCRLMAPYTPFITELMYQNL 785
Cdd:TIGR00392 710 EVNEALEKYNFHKVLRALQDFIVEeLSNWYIRIIRDRLYCEAKDNDKRAAQTTLYYALLTLVRLLAPFLPHTAEEIYQNL 789
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 975090365 786 KTlidpasvqEKNTDSIHYLMLPQAREDLIDKNIESAVSRMQSVIELGRVIRDRKTIPVKYPLKEVVVIHHDPQVLEVI 864
Cdd:TIGR00392 790 PG--------GEEEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLEAVLKAV 860
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
17-639 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 918.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 17 KILQFWNRLDCFQECLKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHGLPVEYEI 96
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 97 DKMLGIKGPEDVAKMGIAEYNNNCRGIVMRYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFKQLYDKGLVYRGV 176
Cdd:pfam00133 81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 177 KVMPFSTACNTPLSNFEShqNYKDVQDPSVIVSFPLEEDESISLVAWTTTPWTLPSNLALCVNPELQYVKVKDKnigkiF 256
Cdd:pfam00133 161 KLVNWSPALNTALSNLEV--EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVITGEG-----Y 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 257 ILMEARLISLYKSEKEYSVLDRFPGISLKGKKYKPLFeyfikckENGAFTVVTDNYVKEEEGTGVVHQAPYFGADDYRVC 336
Cdd:pfam00133 234 ILAEALLKSLYKKGTDKKILEDFRGKELEGKEAIHPF-------VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 337 MDFNIiqkdsVPVCPVDASGCFTAEVTDFAGQYVKDADKNIIKALKERGRLIHISSFKHSYPFCWRSETPLIYKAVPSWF 416
Cdd:pfam00133 307 QRHNL-----EVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWF 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 417 VRVEHMVDRLLENNAQCYWVPDFvREKRFGNWLRDARDWAISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEEL---SGV 493
Cdd:pfam00133 382 VRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGrfeEEG 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 494 KVTDLHRESVDQVtvpsRCGKGVLHRISEVFDCWFESGSMPYAQVHYPFENKKEFEDA*PADFIAEGIDQPRGWFYTLLV 573
Cdd:pfam00133 461 SIKWLHREAKDKL----GYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIM 536
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 975090365 574 LSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVNIVNSYGADALRLYLINSPVVRAENLR 639
Cdd:pfam00133 537 LSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
39-640 |
4.37e-135 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 416.25 E-value: 4.37e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 39 PRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHGLPVEYEIDKMLGIKGPEDVAKMGiaeynn 118
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMG------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 119 ncrgiVMRYSQEWKASVMrlgRWIDfdndyktlypEFMESvwwvFKQLydkglvyrGVKVmpfstacntplsnfeshqny 198
Cdd:cd00818 75 -----IAEFNAKCREFAL---RYVD----------EQEEQ----FQRL--------GVWV-------------------- 104
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 199 kDVQDPsvivsfpleedesislvawtttpwtlpsnlalcvnpelqYVKVKDKnigkifiLMEarlislyksekeySVLDR 278
Cdd:cd00818 105 -DWENP---------------------------------------YKTMDPE-------YME-------------SVWWV 124
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 279 FPGISLKGKKYKplfeyfikckengaftvvtdnyvkeeegtgvvhqapyfgadDYRVcmdfniiqkdsVPvcpvdasgcf 358
Cdd:cd00818 125 FKQLHEKGLLYR-----------------------------------------GYKV-----------VP---------- 142
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 359 taevtdfagqyvkdadkniikalkergrlihissfkhsypfcWrsetPLIYKAVPSWFVRVEHMVDRLLENNAQCYWVPD 438
Cdd:cd00818 143 ------------------------------------------W----PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPE 176
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 439 FVREkRFGNWLRDARDWAISRNRYWGTPIPLWVSDDFEEVVCigsvaeleelsgvkvtdlhresvdqvtvpsrcgkgvlH 518
Cdd:cd00818 177 WVKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLV-------------------------------------R 218
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 519 RISEVFDCWFESGSMPYAQVHYPFENKKeFEDA*PADFIAEGIDQPRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDG 598
Cdd:cd00818 219 RVPDVLDVWFDSGSMPYAQLHYPFENED-FEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDG 297
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 975090365 599 QKMSKRKKNYPDPVNIVNSYGADALRLYLINSPvVRAENLRF 640
Cdd:cd00818 298 RKMSKSLGNYVDPQEVVDKYGADALRLWVASSD-VYAEDLRF 338
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
10-938 |
5.30e-127 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 413.30 E-value: 5.30e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 10 NFPEEEEKILQFWNRLDCFQecLKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHG 89
Cdd:TIGR00422 6 DPHEVEKKWYKKWEKSGFFK--PDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 90 LPVEYEIDKMLGIKGPE--DVakmGIAEYNNNCRGIVMRYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFKQLY 167
Cdd:TIGR00422 84 IATQVKVEKKLGAEGKTkhDL---GREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 168 DKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVIVSFPLEEDESISLVAWTTTPWTLPSNLALCVNPElqyvkv 247
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEV--EYKEVKGKLYYIRYPLANGSKDYLVVATTRPETMFGDTAVAVHPE------ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 248 kDKNigkifilmearlislYKSekeysvldrfpgisLKGKKYK-PLFEYFIKckengaftVVTDNYVKEEEGTGVVHQAP 326
Cdd:TIGR00422 233 -DER---------------YKH--------------LIGKKVIlPLTGRKIP--------IIADEYVDMEFGTGAVKVTP 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 327 yfgADDYRvcmDFNIIQKDSVP-VCPVDASGCFTAEVTDFAGQYVKDADKNIIKALKERGRLIHISSFKHSYPFCWRSET 405
Cdd:TIGR00422 275 ---AHDFN---DYEWGKRHNLEfINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGT 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 406 PLIYKAVPSWFVRVEHMVDRLLE--NNAQCYWVPDFVrEKRFGNWLRDARDWAISRNRYWGTPIPLWVSDDFEEVVcigs 483
Cdd:TIGR00422 349 VVEPLLSKQWFVKVEKLADKALEaaEEGEIKFVPKRM-EKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGEVY---- 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 484 VAELEELSGVKVTDLHRESVDQVTvpsrcgkgvlhrisEVFDCWFESGSMPYAQVHYPfENKKEFEDA*PADFIAEGIDQ 563
Cdd:TIGR00422 424 VAKEEPLPDDKTNTGPSVELEQDT--------------DVLDTWFSSSLWPFSTLGWP-DETKDLKKFYPTDLLVTGYDI 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 564 PRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVNIVNSYGADALRLYLINSpVVRAENLRFKE- 642
Cdd:TIGR00422 489 IFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASL-VTPGDDINFDWk 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 643 --EGVRDVLKDVFlpwyNAYRFliqnvvILQLKEEGKEFLYNEntvkENNNIMDKWILSFTQSLIQFFRAEMAAYRLYTV 720
Cdd:TIGR00422 568 rvESARNFLNKLW----NASRF------VLMNLSDDLELSGGE----EKLSLADRWILSKLNRTIKEVRKALDKYRFAEA 633
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 721 VPRLVKFV-DILTNWYVRMNRRRLKGENgTDDCIMALETLFSVLFSMCRLMAPYTPFITELMYQNLKtlidpasvqeKNT 799
Cdd:TIGR00422 634 AKALYEFIwNDFCDWYIELVKYRLYNGN-EAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK----------EGA 702
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 800 DSIHYLMLPQAREDLIDKNIESAVSRMQSVIELGRVIRDRKTIPVKYPLKeVVVIHHDPQVLEVIRSLEKYILEELNVRQ 879
Cdd:TIGR00422 703 DSIMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLK-VLLIYTEAETAERLKLNAVDIKGAINFSE 781
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 975090365 880 VTLSTDKDKYGIRL-RAEPDHMVLG--KRLKGAFKSVMTAIKELTSEQLEEFQKTGTIVVEG 938
Cdd:TIGR00422 782 VEVVIEKPEVTEAVvELVPGFEIIIpvKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEG 843
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-888 |
1.54e-105 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 352.96 E-value: 1.54e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 1 MVQQVAENINFPEEEEKILQFWNRLDCFQEclKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVE 80
Cdd:PRK13208 2 MMPELPKKYDPEELEEKWQKIWEEEGTYKF--DPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 81 RRFGWDCHGLPVEYEIDKMLGIKgPEDVAKmgiAEYNNNCRGIVMRYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVW 160
Cdd:PRK13208 80 FPQGWDDNGLPTERKVEKYYGIR-KDDISR---EEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 161 WVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEshQNYKDVQDPSVIVSFPLEEDESIsLVAwTTTPWTLPSNLALCVNP 240
Cdd:PRK13208 156 KSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAE--VEYREREGKLNYIKFPVEDGEEI-EIA-TTRPELLPACVAVVVHP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 241 ElqyvkvkdknigkifilmEARlislYKSekeysvldrfpgisLKGKKYK-PLFEYFIKckengaftVVTDNYVKEEEGT 319
Cdd:PRK13208 232 D------------------DER----YKH--------------LVGKTAIvPLFGVEVP--------ILADPLVDPDFGT 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 320 GVVHqapyfgaddyrVC-----MDFNIIQKDSVPVCPV-DASGCFTAEVTDFAGQYVKDADKNIIKALKERGRLIHISSF 393
Cdd:PRK13208 268 GAVM-----------ICtfgdkTDVTWWRELNLPTRIIiDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLGKQEPI 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 394 KHSYPFCWRSETPLIYKAVPSWFVRVEHMVDRLLENNAQCYWVPDFVReKRFGNWLRD-ARDWAISRNRYWGTPIPLWVS 472
Cdd:PRK13208 337 KHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMR-VRLENWIEGlNWDWCISRQRYFGTPIPVWYC 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 473 DDFEEVVcigsVAELEELSgvkvtdlhresVD-QVTVP-----SRCGKGVLHRISEVFDCWFESGSMPYAQVHYPfENKK 546
Cdd:PRK13208 416 KDCGHPI----LPDEEDLP-----------VDpTKDEPpgykcPQCGSPGFEGETDVMDTWATSSITPLIVTGWE-RDED 479
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 547 EFEDA*PADFIAEGIDQPRGW-FYTLLvLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVNIVNSYGADALRL 625
Cdd:PRK13208 480 LFEKVFPMDLRPQGHDIIRTWlFYTIL-RAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVRY 558
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 626 YLINSPVvrAENLRFKEEGV----RDVLKdvflpWYNAYRFliqnvvILQLKEegkeflYNENTVKENNNIMDKWILSFT 701
Cdd:PRK13208 559 WAASARL--GSDTPFDEKQVkigrRLLTK-----LWNASRF------VLHFSA------DPEPDKAEVLEPLDRWILAKL 619
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 702 QSLIQFFRAEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGTDDCIMALETLFSVLFSMCRLMAPYTPFITEL 780
Cdd:PRK13208 620 AKVVEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEE 699
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 781 MYQNLKtlidpasvqeknTDSIHYLMLPQAREDLIDKNIESAVSRMQSVIELGRVIRDRKTIPVKYPLKEVVVihHDPQV 860
Cdd:PRK13208 700 VWSWLY------------GGSVHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEV--YGPAD 765
|
890 900
....*....|....*....|....*...
gi 975090365 861 LEVIRSLEKYILEELNVRQVTLSTDKDK 888
Cdd:PRK13208 766 LELLEAAEEDLKAAGNIEELELVEGDPE 793
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
10-785 |
7.73e-103 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 349.84 E-value: 7.73e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 10 NFPEEEEKILQFWNRLDCFQEcLKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHG 89
Cdd:PLN02843 4 NSVTREPEIQKLWEENQVYKR-VSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 90 LPVEYeidKMLGIKGPEDVAKMGIAEYNNNCRGIVMRYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFKQLYDK 169
Cdd:PLN02843 83 LPIEL---KVLQSLDQEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 170 GLVYRGVKVMPFSTACNTPLSnfESHQNYKDVQ-DPSVIVSFPL---------EEDE---SISLVAWTTTPWTLPSNLAL 236
Cdd:PLN02843 160 GYIYRGRKPVHWSPSSRTALA--EAELEYPEGHvSKSIYVAFPVvspsetspeELEEflpGLSLAIWTTTPWTMPANAAV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 237 CVNPELQYVKVK----------------------DKNIGKIFILMEARLISLY--KSEKEYSVLDRFPGISLKGKKYK-P 291
Cdd:PLN02843 238 AVNDKLQYSVVEvqsfsedestsggnkkkrpgnvLKEQQKLFLIVATDLVPALeaKWGVKLVVLKTFPGSDLEGCRYIhP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 292 LFeyfikckENGAFTVVTDNYVKEEEGTGVVHQAPYFGADDYRVCMdfniiqKDSVP-VCPVDASGCFTAEVTDFAGQYV 370
Cdd:PLN02843 318 LY-------NRESPVVIGGDYITTESGTGLVHTAPGHGQEDYITGL------KYGLPlLSPVDDAGKFTEEAGQFSGLSV 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 371 -KDADKNIIKALKERGRLIHISSFKHSYPFCWRSETPLIYKAVPSWFVRVEHMVDRLLENNAQCYWVPDfVREKRFGNWL 449
Cdd:PLN02843 385 lGEGNAAVVEALDEAGSLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPA-QGENRIRAMV 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 450 RDARDWAISRNRYWGTPIPLWVSDDFEEVV----CIGSVAELEELSG------VKVTDLHRESV-DQVtvpSRCGKGvlh 518
Cdd:PLN02843 464 SGRSDWCISRQRTWGVPIPVFYHVETKEPLmneeTIAHVKSIVAQKGsdawwyMDVEDLLPEKYrDKA---SDYEKG--- 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 519 riSEVFDCWFESGSmPYAQVhypfeNKKEFEDA*PADFIAEGIDQPRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDG 598
Cdd:PLN02843 538 --TDTMDVWFDSGS-SWAGV-----LGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKG 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 599 QKMSKRKKNYPDPVNIV----NS-----YGADALRLY----------LINSPVVRAenlrfkeegvrdvLKDVFLPWYNA 659
Cdd:PLN02843 610 FKMSKSLGNVVDPRLVIeggkNQkqepaYGADVLRLWvasvdytgdvLIGPQILKQ-------------MSDIYRKLRGT 676
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 660 YRFLIQNvvilqlkeegkefLYN---ENTVK-ENNNIMDKWILSFTQSLIQFFRAEMAAYRLYTVVPRLVKFVDI-LTNW 734
Cdd:PLN02843 677 LRYLLGN-------------LHDwkpDNAVPyEDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVdLSNF 743
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|..
gi 975090365 735 YVRMNRRRLKGENGTDDCIMALET-LFSVLFSMCRLMAPYTPFITELMYQNL 785
Cdd:PLN02843 744 YLDVAKDRLYVGGTTSFTRRSCQTvLAAHLLSLLRAIAPILPHLAEDAWQNL 795
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
640-834 |
9.36e-89 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 284.83 E-value: 9.36e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 640 FKEEGVRDVLKDVFLPWYNAYRFLIQNVVILQLKEEgkeflyNENTVKENNNIMDKWILSFTQSLIQFFRAEMAAYRLYT 719
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYANLDGFDPG------KDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 720 VVPRLVKFVDILTNWYVRMNRRRLKGENGTDDCIMALETLFSVLFSMCRLMAPYTPFITELMYQNLKTLIDpasvqeKNT 799
Cdd:cd07961 75 AVRALLEFIDELTNWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELG------DAP 148
|
170 180 190
....*....|....*....|....*....|....*
gi 975090365 800 DSIHYLMLPQAREDLIDKNIESAVSRMQSVIELGR 834
Cdd:cd07961 149 ESVHLLDWPEVDESLIDEELEEAMELVREIVELGR 183
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
15-886 |
2.29e-70 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 254.21 E-value: 2.29e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 15 EEKILQFWNRLDCFQEclKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVErrfgWdchgLP--- 91
Cdd:COG0525 13 EAKWYQYWEENGYFKA--DPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTL----W----QPgtd 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 92 ---------VEyeidKMLGIKGP--EDvakMG-------IAEYNNNCRGIVMRysQeWKasvmRLGRWIDFDNDYKTLYP 153
Cdd:COG0525 83 hagiatqavVE----RQLAEEGKsrHD---LGrekflerVWEWKEESGGTITN--Q-LR----RLGASCDWSRERFTMDE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 154 EFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVIVSFPLE-EDESISlVAwTTTPWTLPS 232
Cdd:COG0525 149 GLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV--EHEEVKGHLWHIRYPLAdGSGYIV-VA-TTRPETMLG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 233 NLALCVNPElqyvkvkDKnigkifilmeaRlislYKSekeysvldrfpgisLKGKKYK-PLFEYFIKckengaftVVTDN 311
Cdd:COG0525 225 DTAVAVHPE-------DE-----------R----YKH--------------LIGKTVIlPLVGREIP--------IIADE 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 312 YVKEEEGTGVV-----HqapyfgaddyrvcmDFN---IIQKDSVPVCPV-DASGCFTAEVTDFAGQYVKDADKNIIKALK 382
Cdd:COG0525 261 YVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINIlDEDGTINENAGKYRGLDRFEARKAIVADLE 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 383 ERGRLIHISSFKHSYPFCWRSET---PLIykavpS--WFVRVEHMVDRLLE--NNAQCYWVPD-FvrEKRFGNWLRDARD 454
Cdd:COG0525 327 ELGLLVKVEPHKHSVGHSDRSGTviePYL-----SdqWFVKMKPLAKPAIEavEDGEIKFVPErW--EKTYFHWMENIRD 399
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 455 WAISRNRYWGTPIPLWVSDDFEEVVcigsvaeleelsgvkvtdlhreSVDQVTVPSRCGKGVLHRISEVFDCWFESGSMP 534
Cdd:COG0525 400 WCISRQLWWGHRIPAWYCPDGEVYV----------------------ARTEPEACAKAGSVNLTQDEDVLDTWFSSALWP 457
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 535 YAQVHYPfENKKEFEDA*PADfiaegidqprgwfytllVLSTA---LF--------------GKPPFKNVIVNGLVLASD 597
Cdd:COG0525 458 FSTLGWP-EKTEDLKYFYPTS-----------------VLVTGfdiIFfwvarmimmglhftGEVPFKDVYIHGLVRDEQ 519
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 598 GQKMSKRKKNYPDPVNIVNSYGADALRLYLI--NSPvvrAENLRFKE---EGVRDvlkdvF---LpWyNAYRFLIQNvvi 669
Cdd:COG0525 520 GRKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIKFDEervEGYRN-----FankL-W-NASRFVLMN--- 586
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 670 lqlkEEGKEflYNENTVKENNNIMDKWILSFTQSLIQFFRAEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENG 748
Cdd:COG0525 587 ----LEGFD--PGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwNEFCDWYLELAKPRLYGGDE 660
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 749 TDDcIMALETLFSVLFSMCRLMAPYTPFITELMYQNLKTLIDPASvqekntdsihyLML---PQAREDLIDKNIESAVSR 825
Cdd:COG0525 661 AAK-RETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGES-----------IMLapwPEADEELIDEEAEAEFEW 728
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 975090365 826 MQSVIELGRVIRDRKTIPVKYPLKeVVVIHHDPQVLEVIRSLEKYILEELNVRQVTLSTDK 886
Cdd:COG0525 729 LKEVISAIRNIRAEMNIPPSKKLP-LLLKGADEADRARLEENAAYIKRLARLEEITILVDE 788
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
15-888 |
3.41e-68 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 247.71 E-value: 3.41e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 15 EEKILQFWNRLDCFQeclKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVErrfgWdchgLP--- 91
Cdd:PRK05729 15 EAKWYQKWEEKGYFK---PDDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTL----W----LPgtd 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 92 ---------VEyeidKMLGIKGP--EDvakMGIAEYnnncrgivMRYSQEWKAS--------VMRLGRWIDFDNDYKTLY 152
Cdd:PRK05729 84 hagiatqmvVE----RQLAAEGKsrHD---LGREKF--------LEKVWEWKEEsggtitnqLRRLGASCDWSRERFTMD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 153 PEFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVIVSFPLEE-DESISlVAwTTTPWTLP 231
Cdd:PRK05729 149 EGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV--EYKEVKGKLWHIRYPLADgSDYLV-VA-TTRPETML 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 232 SNLALCVNPElqyvkvkDKnigkifilmeaRlislYKSekeysvldrfpgisLKGKKYK-PLFEYFIKckengaftVVTD 310
Cdd:PRK05729 225 GDTAVAVNPE-------DE-----------R----YKH--------------LIGKTVIlPLVGREIP--------IIAD 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 311 NYVKEEEGTGVV-----HqapyfgaddyrvcmDFN---IIQKDSVPVCPV-DASGCFTAEVTDFAGQYVKDADKNIIKAL 381
Cdd:PRK05729 261 EYVDPEFGTGAVkitpaH--------------DPNdfeVGKRHNLPMINImDEDGTINENPGEYQGLDRFEARKAIVADL 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 382 KERGRLIHISSFKHSYPFCWRSET---PLIYKavpSWFVRVEHMVDRLLE--NNAQCYWVPD-FvrEKRFGNWLRDARDW 455
Cdd:PRK05729 327 EELGLLVKIEPHTHSVGHSDRSGVviePYLSD---QWFVKMKPLAKPALEavENGEIKFVPErW--EKTYFHWMENIQDW 401
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 456 AISRNRYWGTPIPLWVSDDFEEVVcigsvAELEelsgvkvtdlhresvdqvtvPSRCGKGVLHRISEVFDCWFESGSMPY 535
Cdd:PRK05729 402 CISRQLWWGHRIPAWYDEDGEVYV-----GREE--------------------PEAREKALLTQDEDVLDTWFSSALWPF 456
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 536 AQVHYPfENKKEFEDa*padfiaegidqprgwFY--TLLV---------------LSTALFGKPPFKNVIVNGLVLASDG 598
Cdd:PRK05729 457 STLGWP-EKTEDLKR-----------------FYptSVLVtgfdiiffwvarmimMGLHFTGQVPFKDVYIHGLVRDEQG 518
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 599 QKMSKRKKNYPDPVNIVNSYGADALRLYLI--NSPvvrAENLRFKE---EGVRDvlkdvF---LpwYNAYRFLIQNvviL 670
Cdd:PRK05729 519 RKMSKSKGNVIDPLDLIDKYGADALRFTLAalASP---GRDIRFDEervEGYRN-----FankL--WNASRFVLMN---L 585
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 671 QLKEEGKEFLYNENTvkennnIMDKWILSFTQSLIQFFRAEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGT 749
Cdd:PRK05729 586 EGADVGELPDPEELS------LADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIwNEFCDWYLELAKPVLQEAAKR 659
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 750 ddciMALETLFSVLFSMCRLMAPYTPFITELMYQNLKTLIDPASvqekntdsihyLML---PQAREDLiDKNIESAVSRM 826
Cdd:PRK05729 660 ----ATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEES-----------IMLapwPEADEAI-DEAAEAEFEWL 723
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 975090365 827 QSVIELGRVIRDRKTIPVKYPLKeVVVIHHDPQVLEVIRSLEKYILEELNVRQVTLSTDKDK 888
Cdd:PRK05729 724 KELITAIRNIRAEMNIPPSKKLP-LLLKGADAEDRARLEANEAYIKRLARLESLEILADDEE 784
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
13-868 |
1.30e-66 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 245.67 E-value: 1.30e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 13 EEEEKILQFWNRLDCFQeCLKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHGLPV 92
Cdd:PRK14900 23 EVEARWYPFWQERGYFH-GDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIAT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 93 EYEIDKMLgiKGPEDVAKMGIAeynnncRGIVMRYSQEWKASV--------MRLGRWIDFDNDYKTLYPEFMESVWWVFK 164
Cdd:PRK14900 102 QMIVEKEL--KKTEKKSRHDLG------REAFLERVWAWKEQYgsrigeqhKALGASLDWQRERFTMDEGLSRAVREVFV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 165 QLYDKGLVYRGVKVMPFSTACNTPLSNFE-SHQNYKDVQDPSVivSFPLEeDESISLVAWTTTPWTLPSNLALCVNPElq 243
Cdd:PRK14900 174 RLHEEGLIYREKKLINWCPDCRTALSDLEvEHEEAHQGELWSF--AYPLA-DGSGEIVVATTRPETMLGDTAVAVHPL-- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 244 yvkvkdknigkifilmEARLISLYKSEKEYSVLDRfpgislkgkkykplfeyfikckengAFTVVTDN-YVKEEEGTGVV 322
Cdd:PRK14900 249 ----------------DPRYMALHGKKVRHPITGR-------------------------TFPIVADAiLVDPKFGTGAV 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 323 HQAPyfgADDYRvcmDFNIIQKDSVPVCPV-DASGCFTAEVTDFAGQYVKDADKNIIKALKERGRLIHISSFKHSYPFCW 401
Cdd:PRK14900 288 KVTP---AHDFN---DFEVGKRHGLEMITViGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQ 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 402 RSETPLIYKAVPSWFVRVEHMVDRLLENNAQ--CYWVPDFVREKRFGnWLRDARDWAISRNRYWGTPIPLWVSDDFEEVV 479
Cdd:PRK14900 362 RSATILEPLLSDQWYVRIEPLARPAIEAVEQgrTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQIPAWYCPDGHVTV 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 480 CigsvaeleelsgvkvtdlhREsvdQVTVPSRCGKGVLHRISEVFDCWFESGSMPYAQVHYPfENKKEFEDA*PADFIAE 559
Cdd:PRK14900 441 A-------------------RE---TPEACSTCGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTSVMET 497
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 560 GIDQPRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVNIVNSYGADALRLYLInSPVVRAENLR 639
Cdd:PRK14900 498 GHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLA-ALTAQGRDIK 576
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 640 FKE---EGVRDVLKDVflpwYNAYRFLIQNVVILQLKEegkeflynENTVKENNNIMDKWILSFTQSLIQFFRAEMAAYR 716
Cdd:PRK14900 577 LAKeriEGYRAFANKL----WNASRFALMNLSGYQERG--------EDPARLARTPADRWILARLQRAVNETVEALEAFR 644
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 717 LYTVVPRLVKFV-DILTNWYVRMNRRRLKGEN-GTDDCIMAleTLFSVLFSMCRLMAPYTPFITELMYQNLktlidPASV 794
Cdd:PRK14900 645 FNDAANAVYAFVwHELCDWYIELAKEALASEDpEARRSVQA--VLVHCLQTSYRLLHPFMPFITEELWHVL-----RAQV 717
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 975090365 795 Q-EKNTDSIHYLMLPqaREDLIDKNIESAVSRMQSVIELGRVIRDRKTIPVKYPL---KEVVVIHHDPQVLEVIRSLE 868
Cdd:PRK14900 718 GaSAWADSVLAAEYP--RKGEADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLgaqAPVEIAVADPALRDLLQAGE 793
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
47-630 |
2.88e-52 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 188.61 E-value: 2.88e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 47 PPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHGLPVEYEIDKMLGIKGPEDvAKMGIAEYNNNCRGIVMR 126
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTR-HDLGREEFLEKCWEWKEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 127 YSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFKQLYDKGLVYRGvkvmpfstacntplsnfeshqNYkdvqdpsv 206
Cdd:cd00817 88 SGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRD---------------------NR-------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 207 ivsfpleedesisLVAWTTtpwtlpsnlalcvnpelqyvkvkdknigkifilmearlislyksekeysvldrfpgislkg 286
Cdd:cd00817 139 -------------LVNWCP------------------------------------------------------------- 144
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 287 kkykplfeyfiKCKengafTVVTDnyvkeeegtgvvhqapyfgaddyrvcmdfniiqkdsvpvcpvdasgcftAEVtdfa 366
Cdd:cd00817 145 -----------KLR-----TAISD-------------------------------------------------IEV---- 155
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 367 gqyvkdadkniikalkergrlihissfkhsypfCWRSETPLIYKAVPSWFVRVEHMVDRLLE--NNAQCYWVPDFVrEKR 444
Cdd:cd00817 156 ---------------------------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEavKEGDIKFVPERM-EKR 201
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 445 FGNWLRDARDWAISRNRYWGTPIPLWVSDDFEEVVcigsVAELEELsgvkvtdlhRESVDQVTVPSRCGKGVLHRISEVF 524
Cdd:cd00817 202 YENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWV----VAREEDE---------AIDKAAPEACVPCGGEELKQDEDVL 268
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 525 DCWFESGSMPYAQVHYPfENKKEFEDA*PADFIAEGIDQPRGW-FYTLLvLSTALFGKPPFKNVIVNGLVLASDGQKMSK 603
Cdd:cd00817 269 DTWFSSSLWPFSTLGWP-EETKDLKKFYPTSLLVTGHDIIFFWvARMIM-RGLKLTGKLPFKEVYLHGLVRDEDGRKMSK 346
|
570 580
....*....|....*....|....*..
gi 975090365 604 RKKNYPDPVNIVNSYGADALRLYLINS 630
Cdd:cd00817 347 SLGNVIDPLDVIDGYGADALRFTLASA 373
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
15-890 |
1.49e-50 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 195.22 E-value: 1.49e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 15 EEKILQFWNRLDCFQ--ECLKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHGLPV 92
Cdd:PTZ00419 34 ESGWYEWWEKSGFFKpaEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIAT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 93 EYEIDKMLGIKGPEDVAKMGIAEYnnncrgivMRYSQEWK---ASVM-----RLGRWIDFDNDYKTLYPEFMESVWWVFK 164
Cdd:PTZ00419 114 QVVVEKKLMKEENKTRHDLGREEF--------LKKVWEWKdkhGNNIcnqlrRLGSSLDWSREVFTMDEQRSKAVKEAFV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 165 QLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPSVI----------------VSFPLEEDESISLVAWTTTPW 228
Cdd:PTZ00419 186 RLYEDGLIYRDTRLVNWCCYLKTAISDIEV--EFEEIEKPTKItipgydkkvevgvlwhFAYPLEDSGQEEIVVATTRIE 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 229 TLPSNLALCVNPelqyvkvKDKNigkifilmearlislYKSekeysvldrfpgisLKGKKYK-PlfeyFIKCKEngaFTV 307
Cdd:PTZ00419 264 TMLGDVAVAVHP-------KDER---------------YKK--------------LHGKELIhP----FIPDRK---IPI 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 308 VTD-NYVKEEEGTGVVHQAPyfgADDYRvcmDFNIIQKDSVPVCPV-DASGCFTAEVTDFAGQYVKDADKNIIKALKERG 385
Cdd:PTZ00419 301 IADdELVDMEFGTGAVKITP---AHDPN---DYEIAKRHNLPFINIfTLDGKINENGGEFAGMHRFDCRRKIEEELKEMG 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 386 RLIHISSFKHSYPFCWRSETPLIYKAVPSWFVRVEHMVDRLLEN--NAQCYWVPDFVREKRFgNWLRDARDWAISRNRYW 463
Cdd:PTZ00419 375 LLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAvrNGELKIIPSSHENVWY-HWLENIQDWCISRQLWW 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 464 GTPIP-----------------LWV-SDDFEEvvcigSVAELEELSGVKVTDLHresvdqvtvpsrcgkgvLHRISEVFD 525
Cdd:PTZ00419 454 GHRIPayrviskgpetdpsdeePWVvARSEEE-----ALEKAKKKFGLSEEDFE-----------------LEQDEDVLD 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 526 CWFESGSMPYAQVHYPfENKKEFEDA*PADFIAEGIDQPRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRK 605
Cdd:PTZ00419 512 TWFSSGLFPFSTLGWP-DQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSK 590
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 606 KNYPDPVNIVNSYGADAL--RLYLINSP---VVRAENLRFKE--EGV-------------------RDVLKDV------- 652
Cdd:PTZ00419 591 GNVIDPLEVIEGISLQDLnqKLYEGNLPekeIKRAIELQKKEfpNGIpecgtdalrfgllaytqqgRNINLDInrvvgyr 670
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 653 -FLP--WyNAYRFLIQNvvILQLKEEGKEFLYNENTVkENNNIMDKWILSFTQSLI----------QFFRAEMAAYRLYt 719
Cdd:PTZ00419 671 hFCNklW-NAVKFALMK--LLKDFNLPNSTLFKPNNV-ESLPWEDKWILHRLNVAIkevtegfkeyDFSEATQATYNFW- 745
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 720 vvprLVKFVDIltnwYVRMNRRRLKGENGTDDCIMALETLFSVLFSMCRLMAPYTPFITELMYQNLktlidPASVQEknT 799
Cdd:PTZ00419 746 ----LYELCDV----YLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRL-----PNYLRK--S 810
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 800 DSIHYLMLPQAREDLIDKNIESAVSRMQSVIELGRVIRDRKTIPVKYPLKEVVVIHHDPQ------VLEVIRSLEKyiLE 873
Cdd:PTZ00419 811 ESISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELieliesAENLISTLAK--IG 888
|
970
....*....|....*..
gi 975090365 874 ELNVRQVTLSTDKDKYG 890
Cdd:PTZ00419 889 SVSVIPPIEEEAEVPKG 905
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
4-785 |
2.51e-50 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 194.00 E-value: 2.51e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 4 QVAENINFpEEEEKILQFWNRLDCFQECLKQSKNRprFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRF 83
Cdd:PLN02943 56 ETAKSFDF-TSEERIYNWWESQGYFKPNFDRGGDP--FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIP 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 84 GWDCHGLPVEYEIDKMLGIKGPEDVaKMGIAEYNNNCRGIVMRYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVF 163
Cdd:PLN02943 133 GTDHAGIATQLVVEKMLASEGIKRT-DLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAF 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 164 KQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNykdvQDPSVI--VSFPLEEDESISLVAWTTTPWTLPSNLALCVNPE 241
Cdd:PLN02943 212 VRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYS----EEPGTLyyIKYRVAGGSEDFLTIATTRPETLFGDVAIAVNPE 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 242 LQYVKvkdKNIGKIFIlmearlislyksekeysvldrfpgISLKGKKYKPlfeyfikckengaftVVTDNYVKEEEGTGV 321
Cdd:PLN02943 288 DDRYS---KYIGKMAI------------------------VPMTYGRHVP---------------IIADRYVDKDFGTGV 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 322 VHQAPYFGADDYRVCMDF-----NIIQKDsvpvcpvdasgcftAEVTDFAGQYVKDADKNIIKALKERGRLIHISSFKHS 396
Cdd:PLN02943 326 LKISPGHDHNDYLLARKLglpilNVMNKD--------------GTLNEVAGLYWFEAREKLWSDLEETGLAVKKEPHTLR 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 397 YPfcwRSE------TPLIYKavpSWFVRVEHMVDRLLE--NNAQCYWVPDFVrEKRFGNWLRDARDWAISRNRYWGTPIP 468
Cdd:PLN02943 392 VP---RSQrggeviEPLVSK---QWFVTMEPLAEKALKavENGELTIIPERF-EKIYNHWLSNIKDWCISRQLWWGHRIP 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 469 LW--VSDDFEEVVCigsVAELEELSGVKVTDLHRESVDqvtvpsrcgkgvLHRISEVFDCWFESGSMPYAQVHYPFENKK 546
Cdd:PLN02943 465 VWyiVGKDCEEDYI---VARSAEEALEKAREKYGKDVE------------IYQDPDVLDTWFSSALWPFSTLGWPDVSAE 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 547 EFEDA*PADFIAEGIDQPRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVNIVNSYGADALRLY 626
Cdd:PLN02943 530 DFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFT 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 627 LINSPVVRAENLRFKEEGVRDVLKDVFlpwYNAYRFLIQNV----------VILQLKEEGKEFLynentvkENNNIMDKW 696
Cdd:PLN02943 610 LALGTAGQDLNLSTERLTSNKAFTNKL---WNAGKFVLQNLpsqsdtsaweHILACKFDKEESL-------LSLPLPECW 679
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 697 ILSFTQSLIQFFRAEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGTDDCIMALETLFSVLFSMCRLMAPYTP 775
Cdd:PLN02943 680 VVSKLHELIDSVTTSYDKYFFGDVGREIYDFFwSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMP 759
|
810
....*....|
gi 975090365 776 FITELMYQNL 785
Cdd:PLN02943 760 FVTEELWQAL 769
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
407-628 |
5.78e-47 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 171.06 E-value: 5.78e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 407 LIYK------AVPSWFVRVEHMVDRLLENNAQCYWVPDFVReKRFGNWLRDARDWAISRNRYWGTPIPLWVsddfeevvc 480
Cdd:cd00668 128 LIYRgthpvrITEQWFFDMPKFKEKLLKALRRGKIVPEHVK-NRMEAWLESLLDWAISRQRYWGTPLPEDV--------- 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 481 igsvaeleelsgvkvtdlhresvdqvtvpsrcgkgvlhrisevFDCWFESGSMPYAQVHYPFENKkEFEDA*PADFIAEG 560
Cdd:cd00668 198 -------------------------------------------FDVWFDSGIGPLGSLGYPEEKE-WFKDSYPADWHLIG 233
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 975090365 561 IDQPRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVNIVNSYGADALRLYLI 628
Cdd:cd00668 234 KDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLT 301
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
10-844 |
1.26e-40 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 162.61 E-value: 1.26e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 10 NFPEEEEKILQFWNRLDCFQecLKQSKNRPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHG 89
Cdd:TIGR00396 2 NHIEIEEKWQQKWDENKTFK--VTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 90 LPVE-YEIDKML--GIKGPEDVAKMgiaeynnncrgivmrysqewKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFKQL 166
Cdd:TIGR00396 80 LPAEnAAIKRGIhpAKWTYENIANM--------------------KKQLQALGFSYDWDREIATCDPEYYKWTQWIFLEL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 167 YDKGLVYRgvKVMPF--------------------STACNTP--------------------LSNFES----HQNYKDVQ 202
Cdd:TIGR00396 140 FEKGLAYV--KEADVnwcpndgtvlaneqvdsdgrSWRGDTPvekkelkqwflkitayaeelLNDLEEldhwPESVKEMQ 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 203 ------DPSVIVSFPLEeDESISLVAWTTTPWTLPSNLALCVNPELQYVKVKDKNIGKI--FILMEARlislyKSEKEYS 274
Cdd:TIGR00396 218 rnwigkSEGVEITFKIA-DHDEKITVFTTRPDTIFGVTYLALAPEHPLVEKAAENNPKVaaFIKKILN-----KTVAERT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 275 VLDRFP-GISLKGKKYKPLfeyfikckENGAFTVVTDNYVKEEEGTGVVHQAPyfgADDYRvcmDFNIIQKDSVPVCPVd 353
Cdd:TIGR00396 292 KATKEKkGVDTGIKAIHPL--------TGEKIPIWVANYVLMEYGTGAVMGVP---AHDER---DFEFAQKYGLPIKPV- 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 354 asgcftaevtdfagqyVKDADKNIIKALKERGRLIHISSFKHSypfcwRSETPLIYKAVPSWFVRvehmvdrllENNAqc 433
Cdd:TIGR00396 357 ----------------IDPAEKDLSLTAAYTEDGVLVNSGEFN-----GLNSSEARNAIIDMLEK---------EGKG-- 404
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 434 ywvpdfvreKRFGNWlrDARDWAISRNRYWGTPIPLWVSDDFEEVVCIGS-----VAELEELSGVKVTDLHR-ESVDQVT 507
Cdd:TIGR00396 405 ---------KRKVNY--RLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEdlpviLPEDVVYDGDGGSPLSRiPEWVNVT 473
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 508 VPSrCGKGVLhRISEVFDCWFESG--SMPYAQVHYP--FENKKEFEDA*PADFIAEGIDQP-------RGW---FYTLLV 573
Cdd:TIGR00396 474 CPS-CGKPAL-RETDTMDTFAGSSwyYLRYLDPKNTdgPFDKEKAEYWLPVDLYIGGIEHAilhllyaRFFhkfLRDIGY 551
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 574 LSTalfgKPPFKNVIVNGLVLA-------------------------------SDGQKMSKRKKNYPDPVNIVNSYGADA 622
Cdd:TIGR00396 552 VNT----KEPFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyVGYEKMSKSKGNGIDPQEIVESYGADA 627
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 623 LRLYLI-NSPVvrAENLRFKEEGVRdvlkdvflpwyNAYRFL--IQNVVILQLKEEGKEFLYN---ENTVKENNNIMDKW 696
Cdd:TIGR00396 628 LRLFIMfMGPI--AASLEWNESGLE-----------GARRFLdrVWNLVYEITGELDAASLTVtalEEAQKELRRDVHKF 694
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 697 ILSFTQSLIQffraemaAYRLYTVVPRLVKFVDILTNwyvrmnrrrlkgengTDDCIMALETLFSVLfsmcRLMAPYTPF 776
Cdd:TIGR00396 695 LKKVTEDLEK-------RESFNTAISAMMELLNKLYK---------------AKKEALMLEYLKGFV----TVLSPFAPH 748
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 975090365 777 ITELMYQNLKTlidpasvqekNTDSIHYLMLPQAREDLIDKNiesavsRMQSVIELGRVIRDRKTIPV 844
Cdd:TIGR00396 749 LAEELWEKLGS----------EPFIIDNAKWPVVDETALVED------KTLIVVQVNGKFRAKITVPK 800
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
54-929 |
5.03e-38 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 154.64 E-value: 5.03e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 54 PHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHGLPV-----------EYEID---KMLGIkgPEDV-AKMG----IA 114
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPIlgiaeriargdPETIElykSLYGI--PEEElEKFKdpeyIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 115 EYnnncrgivmrYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLsnfES 194
Cdd:PRK12300 79 EY----------FSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPV---GD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 195 HqNYKDVQDPSvIVSFPL---EEDESISLVAWTTTPWTLPSNLALCVNPELQYVKVKDKniGKIFILMEARLISLYKSEK 271
Cdd:PRK12300 146 H-DLLDGEEPE-IVEYTLikfEESEDLILPAATLRPETIFGVTNLWVNPDATYVKAEVD--GEKWIVSKEAAEKLSFQDR 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 272 EYSVLDRFPGISLKGKKYK-PLFEYFIKckengaftVVTDNYVKEEEGTGVV-----HqAPYfgadDYRVCMDFNIIQKD 345
Cdd:PRK12300 222 DVEIIEEIKGSELIGKKVKnPVTGKEVP--------ILPADFVDPDNGTGVVmsvpaH-APY----DYVALRDLKKNKEL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 346 S-----VPVCPVDASGCFTAE------------------------------------VTDFAGQYVKDADKNIIKALKER 384
Cdd:PRK12300 289 LdviepIPLIEVEGYGEFPAKevveklgiksqedpeleeatkevyraefhkgvlkenTGEYAGKPVREAREKITKDLIEK 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 385 GRLIHISSFKHSYPFCwRSETPLIYKAVP-SWFV---------RVEHMVDRLlennaqcYWVPDFVReKRFGN---WLRD 451
Cdd:PRK12300 369 GIADIMYEFSNRPVYC-RCGTECVVKVVKdQWFIdysdpewkeLAHKALDNM-------EIIPEEYR-KEFENtidWLKD 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 452 ardWAISRNRYWGTPIPlWvsdDFEEVVcigsvaelEELS------------------GVKVTDLHRESVDQVTVpsrcG 513
Cdd:PRK12300 440 ---RACARRRGLGTRLP-W---DEEWII--------ESLSdstiymayytiahkireyGIKPEQLTPEFFDYVFL----G 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 514 KGVLHRISEvfdcwfESGsMPYAQVHypfENKKEFEDA*PADFIAEGIDqprgwfytlLV---LS------TALFGK--- 581
Cdd:PRK12300 501 KGDPEEVSK------KTG-IPKEILE---EMREEFLYWYPVDWRHSGKD---------LIpnhLTffifnhVAIFPEekw 561
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 582 PpfKNVIVNGLVLaSDGQKMSKRKKN-YP--DpvnIVNSYGADALRLYLINSpvvrAE-----NLRFKE-EGVRDVLKDv 652
Cdd:PRK12300 562 P--RGIVVNGFVL-LEGKKMSKSKGNvIPlrK---AIEEYGADVVRLYLTSS----AEllqdaDWREKEvESVRRQLER- 630
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 653 flpWYNayrfLIQNVVilqlkeegkeflynENTVKENNNIMDKWILSFTQSLIQFFRAEMAAYRLYTVVPRLvkFVDILT 732
Cdd:PRK12300 631 ---FYE----LAKELI--------------EIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEA--FYELLN 687
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 733 --NWYvrmnRRRLKGENGTddcimALETLFSVLFsmcRLMAPYTPFITELMYQNL--KTLIdpasVQEKntdsihylmLP 808
Cdd:PRK12300 688 dlRWY----LRRVGEANNK-----VLREVLEIWI---RLLAPFTPHLAEELWHKLggEGFV----SLEK---------WP 742
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 809 QAREDLIDKNIESAVSRMQSVIElgrvirDRKTIP--VKYPLKEVVVIHHDPQVLEVIrsleKYILEELNVRQVTLSTDK 886
Cdd:PRK12300 743 EPDESKIDEEAELAEEYVKRLIE------DIREILkvAKIKPKKVYIYVAPDWKYEVL----EIAAENGDVKEAIKELMK 812
|
970 980 990 1000
....*....|....*....|....*....|....*....|...
gi 975090365 887 DKYGIRLRAEPDHMVlgKRLKGAFKSVMTAIKELTSEQLEEFQ 929
Cdd:PRK12300 813 DEELRKHGKEVAKLA--QKIVKEVLKLDKEVRKLILKNIDEEE 853
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
40-178 |
1.13e-36 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 141.40 E-value: 1.13e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 40 RFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHGLPVEYEIDKMLGIKGPEDVakmgIAEYNNN 119
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFRED 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 975090365 120 CRGIVMRYSQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFKQLYDKGLVYRGVKV 178
Cdd:cd00668 77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
4-837 |
1.05e-29 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 128.48 E-value: 1.05e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 4 QVAENINFPEEEEKILQFWNRLDCFQECLKQSKnrPRFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRF 83
Cdd:PLN02381 95 QMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSK--PPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVP 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 84 GWDCHGLPVEYEIDKMLGIKGPEDVAKMGIAEYNNNcrgiVMRYSQEWKASVM----RLGRWIDFDNDYKTLYPEFMESV 159
Cdd:PLN02381 173 GVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSE----VWKWKDEYGGTILnqlrRLGASLDWSRECFTMDEQRSKAV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 160 WWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFEShqNYKDVQDPS--------------VIVSF--PLEEDESISLVAw 223
Cdd:PLN02381 249 TEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEV--DYIDIKERTllkvpgydkpvefgVLTSFayPLEGGLGEIVVA- 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 224 TTTPWTLPSNLALCVNPElqyvkvkdknigkifilmearlislyksEKEYSVLD-RFPGISLKGKKYKplfeyfIKCKEn 302
Cdd:PLN02381 326 TTRIETMLGDTAIAIHPD----------------------------DERYKHLHgKFAVHPFNGRKLP------IICDA- 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 303 gafTVVTDNYvkeeeGTGVVHQAPYFGADDYRV----CMDF-NIIQKDSvpvcPVDASGCftaevTDFAGQYVKDADKNI 377
Cdd:PLN02381 371 ---ILVDPNF-----GTGAVKITPAHDPNDFEVgkrhNLEFiNIFTDDG----KINSNGG-----SEFAGMPRFAAREAV 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 378 IKALKERGRLIHISSFKHSYPFCWRSE---TPLIYkavPSWFVRVEHMVDRLLE-----NNAQCYWVPDfVREKRFGNWL 449
Cdd:PLN02381 434 IEALQKKGLYRGAKNNEMRLGLCSRTNdvvEPMIK---PQWFVNCSSMAKQALDaaidgENKKLEFIPK-QYLAEWKRWL 509
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 450 RDARDWAISRNRYWGTPIPLW---VSDDFEEVVCIGS----VAELEElsgvkvtdlhrESVDQVTVPSRCGKGVLHRISE 522
Cdd:PLN02381 510 ENIRDWCISRQLWWGHRIPAWyvtLEDDQLKELGSYNdhwvVARNES-----------DALLEASQKFPGKKFELSQDPD 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 523 VFDCWFESGSMPYAQVHYPfENKKEFEDA*PADFIAEGIDQPRGWFYTLLVLSTALFGKPPFKNVIVNGLVLASDGQKMS 602
Cdd:PLN02381 579 VLDTWFSSGLFPLSVLGWP-DDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMS 657
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 603 KRKKNYPDPVNIVNSY-------------------------------------GADALRLYLInSPVVRAENLRFkeegv 645
Cdd:PLN02381 658 KSLGNVIDPLEVINGIsleglhkrleegnldpkelvvakegqkkdfpngiaecGTDALRFALV-SYTAQSDKINL----- 731
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 646 rDVLKDV-FLPW----YNAYRFLIQNVvilqlkeeGKEFLYNENTVKENNNIMDKWILSFTQSLIQFFRAEMAAYRLYTV 720
Cdd:PLN02381 732 -DILRVVgYRQWcnklWNAVRFAMSKL--------GDDYTPPATLSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDA 802
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 721 VPRL-----VKFVDIltnwYVRMNRRRLKGENGT--DDCIMALETLFSVLFSMCRLMAPYTPFITELMYQNLktlidPAS 793
Cdd:PLN02381 803 ASTVyswwqYQFCDV----FIEAIKPYFAGDNPEfaSERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRL-----PQP 873
|
890 900 910 920
....*....|....*....|....*....|....*....|....
gi 975090365 794 VQEKNTDSIHYLMLPQAREDLIDKNIESAVSRMQSVIELGRVIR 837
Cdd:PLN02381 874 KDHTRKDSIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCLRSLR 917
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
694-852 |
3.56e-24 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 99.40 E-value: 3.56e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 694 DKWILSFTQSLIQFFRAEMAAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGENGTDdciMALETLFSVLFSMCRLMAP 772
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFwNDLSDWYLELIKDRLYGEEPDS---RAQTTLYEVLETLLRLLAP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 773 YTPFITELMYQNlktlidpasvqekntDSIHYLMLPQAREDLiDKNIESAVSRMQSVIELGRVIRDRKTIPVKYPLKEVV 852
Cdd:pfam08264 78 FMPFITEELWQK---------------ESIHLAPWPEDAELE-EAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
11-626 |
8.00e-22 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 102.59 E-value: 8.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 11 FPEEEEKILQFWNRLDCFQ--ECLKQSKnrPRFTFYDGPPFATGLP-HYGHILAGTIKDIVTRYAHQSGFHVERRFGWDC 87
Cdd:PLN02563 82 FHEIEPKWQRYWEENRTFRtpDDVDTSK--PKFYVLDMFPYPSGAGlHVGHPEGYTATDILARYKRMQGYNVLHPMGWDA 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 88 HGLPVE-YEIDKmlGIKgPEDVAKMGIAeynnncrgivmRYSQEWKAsvmrLGRWIDFDNDYKTLYPEFMESVWWVFKQL 166
Cdd:PLN02563 160 FGLPAEqYAIET--GTH-PKITTLKNIA-----------RFRSQLKS----LGFSYDWDREISTTEPEYYKWTQWIFLQL 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 167 YDKGLVYRGVKVMPFSTACNTPLSNFE---------SH--------------QNYKD--VQD------PSVI-------- 207
Cdd:PLN02563 222 LKRGLAYQAEVPVNWCPALGTVLANEEvvdglsergGHpvirkpmrqwmlkiTAYADrlLEDlddldwPESIkemqrnwi 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 208 -------VSFPL------EEDESISLvaWTTTPWTLPSNLALCVNPELQYVkvkdkniGKIFILMEARLISLYK---SEK 271
Cdd:PLN02563 302 grsegaeLDFSVldgegkERDEKITV--YTTRPDTLFGATYLVVAPEHPLL-------SSLTTAEQKEAVEEYVdaaSRK 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 272 eySVLDRfpgISLKGKKYKPLFEYFIKCKENG-AFTVVTDNYVKEEEGTGVVHQAPyfgADDYRvcmDFNIIQKDSVPVC 350
Cdd:PLN02563 373 --SDLER---TELQKEKTGVFTGSYAINPATGeAIPIWVADYVLGSYGTGAIMAVP---AHDTR---DFEFAQKFDLPIK 441
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 351 PVdasgcftaevtdfagqyVKDADKNII---KALKERGRLIHISSFKHSYPFCWRSETPliyKAVPSWfvrvehmvdrlL 427
Cdd:PLN02563 442 WV-----------------VKPADGNEDdaeKAYTGEGVIVNSSSSGLDINGLSSKEAA---KKVIEW-----------L 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 428 ENNAqcywvpdfVREKRFGNWLrdaRDWAISRNRYWGTPIPLWVSDDFEEVVCIGSVA---ELEELSGVKVTD-----LH 499
Cdd:PLN02563 491 EETG--------NGKKKVNYKL---RDWLFARQRYWGEPIPVVFLEDSGEPVPVPESDlplTLPELDDFTPTGtgeppLA 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 500 ReSVDQV-TVPSRCGKgvlhrisevfdcWF--ESGSMP--------YAQVHYP------FENKKEfEDA*PADFIAEGID 562
Cdd:PLN02563 560 K-AVSWVnTVDPSSGK------------PArrETNTMPqwagscwyYLRFMDPknsnalVDKEKE-KYWMPVDLYVGGAE 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 563 Q-------PRGW---FYTLLVLSTalfgKPPFKNVIVNGLVLA---------SDGQ------------------------ 599
Cdd:PLN02563 626 HavlhllyARFWhkvLYDIGVVST----KEPFQCLVNQGMILGeveytafkdSDGEyvsadtadrlgelqqekipeekvi 701
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 975090365 600 ---------------------KMSKRKKNYPDPVNIVNSYGADALRLY 626
Cdd:PLN02563 702 ksgdsfvlkddpsirliarahKMSKSRGNVVNPDDVVSEYGADSLRLY 749
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
871-1034 |
2.45e-21 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 93.31 E-value: 2.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 871 ILEELNVRQVTLSTDKDKYgIRLRAEPDHMVLGKRLKGAFKSVMTAIKELTSEQLEEFQKTGT--IVVEGH--ELHEEDL 946
Cdd:pfam19302 4 IKEELNVKEVEFGADESEL-VEYSAKPNFPVLGKELGKLMKAAAKEIASLNQMEIQKILDGGTltIDVDGEeiELTSEDL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 947 RLMYTfdqavgGSAHFEAHSDSQVLVLLDVTPDQSMVDEGVAREVINRIQKLRKKRNLVPTDEITVYYRAHPEgdyLDTV 1026
Cdd:pfam19302 83 LVTRQ------GKEGLAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGNEM---LEAA 153
|
....*...
gi 975090365 1027 IKEHTDFI 1034
Cdd:pfam19302 154 IEKFEDYI 161
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
453-844 |
9.67e-17 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 85.87 E-value: 9.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 453 RDWAISRNRYWGTPIPLWVSDDfeevvCiGSVA-----------ELEELSGVKVTDL--HRESVdQVTVPsRCGKGVlHR 519
Cdd:COG0495 420 RDWLISRQRYWGEPIPIIHCED-----C-GVVPvpedqlpvelpEDVDFDPTGGSPLarAPEWV-NVTCP-KCGGPA-RR 490
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 520 ISEVFDCWFESgS---MPYAQVHYpfenkkefeDA*PADFIAE----GIDQ--------------PRgwFYT-LL----V 573
Cdd:COG0495 491 ETDTMDTFVDS-SwyyLRYTDPHN---------DEAPFDPEAAnywlPVDQyiggiehailhllyAR--FFTkVLrdlgL 558
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 574 LSTalfgKPPFKNVIVNGLV--LASDG------QKMSKRKKNYPDPVNIVNSYGADALRLYLI-NSPVVRaeNLRFKEEG 644
Cdd:COG0495 559 VSF----DEPFKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMfAGPPER--DLEWSDSG 632
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 645 VRdvlkdvflpwyNAYRFLiQNVVILQLKEEGKEFLYNENTVKEnnnimDKWILSFTQSLIQFFRAEMAAYRLYTVVPRL 724
Cdd:COG0495 633 VE-----------GAYRFL-NRVWRLVVDEAEALKLDVADLSEA-----DKELRRALHKTIKKVTEDIERLRFNTAIAAL 695
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 725 VKFVDILTnwyvrmnrrRLKGENGTDDCIM--ALETLfsvlfsmCRLMAPYTPFITELMYQNLktlidpasvqeKNTDSI 802
Cdd:COG0495 696 MELVNALY---------KAKDSGEADRAVLreALETL-------VLLLAPFAPHIAEELWERL-----------GHEGSV 748
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 975090365 803 HYLMLPQARED-LIDKNIESAVSRMqsvielGRViRDRKTIPV 844
Cdd:COG0495 749 ADAPWPEADEAaLVEDEVTIVVQVN------GKV-RGKIEVPA 784
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
657-785 |
1.36e-16 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 77.60 E-value: 1.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 657 YNAYRFLIQNVvilqlkeegkEFLYNENTVKENNNIMDKWILSFTQSLIQFFRAEMAAYRLYTVVPRLVKFV-DILTNWY 735
Cdd:cd07962 17 WNAARFVLMNL----------EDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWY 86
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 975090365 736 VRMNRRRLKGENGTDDCImALETLFSVLFSMCRLMAPYTPFITELMYQNL 785
Cdd:cd07962 87 LELVKPRLYGEDEEEKKA-ARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
48-175 |
1.61e-13 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 73.05 E-value: 1.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVERRFGWDCHGLPVEYEIDKmLGIKgPEDvakmgIAEYNnncrgivmry 127
Cdd:cd00812 9 PYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIK-IGRD-PED-----WTEYN---------- 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 975090365 128 SQEWKASVMRLGRWIDFDNDYKTLYPEFMESVWWVFKQLYDKGLVYRG 175
Cdd:cd00812 72 IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKK 119
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
371-628 |
2.73e-12 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 69.48 E-value: 2.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 371 KDADKNIIKALKERGrliHISSFKHSYPFCWRSETPL-IYKAVPSWFVRVEHMVDRLLE---NNAQCYWVPDFVREKRfg 446
Cdd:cd00814 98 KEIVQEFFKKLYENG---YIYEGEYEGLYCVSCERFLpEWREEEHYFFRLSKFQDRLLEwleKNPDFIWPENARNEVL-- 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 447 NWLRDA-RDWAISR-NRYWGTPIPlwvsdDFEevvcigsvaeleelsgvkvtdlhresvdqvtvpsrcgkgvlhriSEVF 524
Cdd:cd00814 173 SWLKEGlKDLSITRdLFDWGIPVP-----LDP--------------------------------------------GKVI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 525 DCWFE------SGSMpyaqvhYPFENKKEFEDA*PAD-----FIAEGIDQPRGWFYTLLVLSTalfGKPPFKNVIVNGLV 593
Cdd:cd00814 204 YVWFDaligyiSATG------YYNEEWGNSWWWKDGWpelvhFIGKDIIRFHAIYWPAMLLGA---GLPLPTRIVAHGYL 274
|
250 260 270
....*....|....*....|....*....|....*
gi 975090365 594 LAsDGQKMSKRKKNYPDPVNIVNSYGADALRLYLI 628
Cdd:cd00814 275 TV-EGKKMSKSRGNVVDPDDLLERYGADALRYYLL 308
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
457-628 |
6.40e-11 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 64.96 E-value: 6.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 457 ISRNRYWGTPIPL-WVSDDFeevvcIGSvaeleelsgvkvtdlhresvdqvtvpsrcgkgvlhrisevfdCWFESGsmpY 535
Cdd:cd00812 169 CSRQRYWGTPIPWtDTMESL-----SDS------------------------------------------TWYYAR---Y 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 536 AQVHYPF--------ENKKEFEDA*PADFIAEGIDqprgwfytLLVL--------STALFGKP-----PFKNVIVNGLVL 594
Cdd:cd00812 199 TDAHNLEqpyegdleFDREEFEYWYPVDIYIGGKE--------HAPNhllysrfnHKALFDEGlvtdePPKGLIVQGMVL 270
|
170 180 190
....*....|....*....|....*....|....
gi 975090365 595 AsDGQKMSKRKKNYPDPVNIVNSYGADALRLYLI 628
Cdd:cd00812 271 L-EGEKMSKSKGNVVTPDEAIKKYGADAARLYIL 303
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
48-190 |
3.19e-10 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 63.85 E-value: 3.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVerRF--GWDCHGLPVEYEIDKmLGIkGPEDVakmgiaeynnncrgiVM 125
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDV--LFvcGTDEHGTPIELKAEK-EGI-TPEEL---------------VD 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 975090365 126 RYSQEWKASVMRLGrwIDFDNDYKTLYPEFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLS 190
Cdd:pfam09334 69 RYHEIHREDFKKFN--ISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLP 131
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
398-628 |
5.39e-09 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 60.51 E-value: 5.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 398 PFCWRSETPLIYKAVPSWFVRVEHMVDRLLEnnaqcyWV---PDfVREKRFG---NWLRDA-RDWAISRNRYWGTPIPlw 470
Cdd:COG0143 169 PRSAISGAPPELREEEHYFFRLSKYQDRLLE------WIeenPD-IQPEVRNevlSWLKEGlQDLSISRDFDWGIPVP-- 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 471 vsdDFEevvcigsvaeleelsgvkvtdlhresvdqvtvpsrcGKgvlhriseVFDCWFE------SGSMPYAQVHYPFEN 544
Cdd:COG0143 240 ---GDP------------------------------------GK--------VFYVWFDaligyiSATKGYADDRGLPED 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 545 KKEF---EDA*PADFIaegidqprG----WFYTLL---VLSTAlfGKPPFKNVIVNGLVLaSDGQKMSKRKKNYPDPVNI 614
Cdd:COG0143 273 FEKYwpaPDTELVHFI--------GkdiiRFHAIIwpaMLMAA--GLPLPKKVFAHGFLT-VEGEKMSKSRGNVIDPDDL 341
|
250
....*....|....
gi 975090365 615 VNSYGADALRLYLI 628
Cdd:COG0143 342 LDRYGPDALRYYLL 355
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
693-832 |
3.03e-07 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 51.76 E-value: 3.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 693 MDKWILSFTQSLIQFFRAEMAAYRLYTVVPRLVKFV-DILTNWYV-----RM-------NRRRlkgengtddciMALETL 759
Cdd:cd07960 45 LDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCtVDLSAFYLdiikdRLycdakdsLERR-----------SAQTVL 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 975090365 760 FSVLFSMCRLMAPYTPFITELMYQNLKtlidpasvQEKNTDSIHYLMLPQAREDLIDKNIEsavSRMQSVIEL 832
Cdd:cd07960 114 YHILDALLKLLAPILPFTAEEVWEHLP--------GEKKEESVFLEDWPELPEEWKDEELE---EKWEKLLAL 175
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
540-628 |
4.49e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 54.42 E-value: 4.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 540 YPFENKKEFEDA*PAD--FIAEGIDQPRGWFY-TLLVlstALfGKPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVNIVN 616
Cdd:PRK12267 241 YGSDDDELFKKFWPADvhLVGKDILRFHAIYWpIMLM---AL-GLPLPKKVFAHGWWLM-KDGKMSKSKGNVVDPEELVD 315
|
90
....*....|..
gi 975090365 617 SYGADALRLYLI 628
Cdd:PRK12267 316 RYGLDALRYYLL 327
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
642-774 |
5.40e-07 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 49.81 E-value: 5.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 642 EEGVRDVLKDvFLPWYNAYRFLIQNVVILQLKEEGKEFLynentvkennnIMDKWILSFTQSLIQFFRAEMAAYRLYTVV 721
Cdd:cd07375 1 EERLKQARAF-LNRLYRLLSFFRKALGGTQPKWDNELLE-----------EADRELLARLQEFIKRTTNALEALDPTTAV 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 975090365 722 PRLVKFVDILtNWYVRMNRRRLKGENGTDDcimALETLFSVLFSMCRLMAPYT 774
Cdd:cd07375 69 QELFKFTNEL-NWYLDELKPALQTEELREA---VLAVLRAALVVLTKLLAPFT 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
582-731 |
1.00e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 52.96 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 582 PPFKNVIVNG-LVLasDGQKMSKRKKNYPDPVNIVNSYGADALRLYLinspvvraenLRFKEEG-VRDVLKDVFLPWYN- 658
Cdd:PRK11893 282 PLPKRVFAHGfLTL--DGEKMSKSLGNVIDPFDLVDEYGVDAVRYFL----------LREIPFGqDGDFSREAFINRINa 349
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 975090365 659 --AYRF--LIQNVVILQLKeegkeflYNENTVKENNN--IMDKWILSFTQSLIQFFRAEMAAYRLYTVVPRLVKFVDIL 731
Cdd:PRK11893 350 dlANDLgnLAQRTLSMIAK-------NFDGKVPEPGAltEADEALLEAAAALLERVRAAMDNLAFDKALEAILALVRAA 421
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
398-631 |
1.33e-06 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 52.29 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 398 PFCWRSETPLIYKAVPSWFVRVEHMVDRLLEnnaqcyWV--PDFVREKRFGN----WLRDA-RDWAISRNRYWGTPIPlw 470
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLRE------WIeeNNPEWPENVKNmvleWLKEGlKDRAISRDLDWGIPVP-- 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 471 vsdDFEevvcigsvaeleelsgvkvtdlhresvdqvtvpsrcGKgvlhriseVFDCWFESgSMPY-AQVHYPFENKKEFE 549
Cdd:pfam09334 239 ---GAE------------------------------------GK--------VFYVWLDA-PIGYiSATKELSGNEEKWK 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 550 DA*PAD-------FIAEGIDQprgwFYTLL---VLSTALFGKPpfKNVIVNGLVLAsDGQKMSKRKKNYPDPVNIVNSYG 619
Cdd:pfam09334 271 EWWPNDpdtelvhFIGKDIIY----FHTIFwpaMLLGAGYRLP--TTVFAHGYLTY-EGGKMSKSRGNVVWPSEALDRFP 343
|
250
....*....|...
gi 975090365 620 ADALRLYLI-NSP 631
Cdd:pfam09334 344 PDALRYYLArNRP 356
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
47-185 |
3.14e-04 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 44.87 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 47 PPFATGLPHYGHilAGT--IKDIVTRYAHQSGFHVerRF--GWDCHGLpveyeidKML------GIKgPEDVAKmgiaey 116
Cdd:PRK11893 9 IYYPNGKPHIGH--AYTtlAADVLARFKRLRGYDV--FFltGTDEHGQ-------KIQrkaeeaGIS-PQELAD------ 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 975090365 117 nnncrgivmRYSQEWKASVMRLGrwIDFDNDYKTLYPEFMESVWWVFKQLYDKGLVYRGVKVMPFSTAC 185
Cdd:PRK11893 71 ---------RNSAAFKRLWEALN--ISYDDFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRC 128
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
572-630 |
4.20e-04 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 43.34 E-value: 4.20e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 975090365 572 LVLSTALFGKPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVNIVNSYGADALRLYLINS 630
Cdd:cd00672 147 IAQSEAATGKPFARYWLHTGHLTI-DGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
668-785 |
4.72e-04 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 41.04 E-value: 4.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 668 VILQLK---EEGKEFLYNENTVKENNNImDKWILSFTQSLIQFFRAEMAAYRLYTVVPRLvkFVDILT--NWYvrmnRRR 742
Cdd:cd07959 9 AILRLErfyELAEELIETEGELEELTFI-DRWLLSRLNRLIKETTEAYENMQFREALKEG--LYELQNdlDWY----RER 81
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 975090365 743 LKGENGTDdcimaleTLFSVLFSMCRLMAPYTPFITELMYQNL 785
Cdd:cd07959 82 GGAGMNKD-------LLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
575-650 |
1.45e-03 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 42.35 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 575 STALFGKPPFKNVIVNGLVLAsDGQKMSKRKKNYPDPVNIVNSYGADALRLYLI----NSPvvraenLRFKEEGVRDVLK 650
Cdd:pfam01406 229 SEAAFDKQLANYWLHNGHVMI-DGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLsvhyRSP------LDFSEELLEQAKS 301
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
48-174 |
1.91e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 42.45 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 975090365 48 PFATGLPHYGHILAGTIKDIVTRYAHQSGFHVerRF--GWDCHGLPVEYEIDKMlGIKgPEDvakmgiaeynnncrgIVM 125
Cdd:PRK00133 11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEV--LFvcADDAHGTPIMLKAEKE-GIT-PEE---------------LIA 71
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 975090365 126 RYSQEWKASVMRLGrwIDFDNDYKTLYPEFMESVWWVFKQLYDKGLVYR 174
Cdd:PRK00133 72 RYHAEHKRDFAGFG--ISFDNYGSTHSEENRELAQEIYLKLKENGYIYE 118
|
|
| |
