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Conserved domains on  [gi|973165480|gb|KUL05253|]
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YjeF-like protein, hydroxyethylthiazole kinase-related protein [Methanomicrobiales archaeon 53_19]

Protein Classification

NAD(P)H-hydrate epimerase( domain architecture ID 10000547)

NAD(P)H-hydrate epimerase catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 19-462 6.08e-40

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


:

Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 150.02  E-value: 6.08e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  19 MQAIEKNA-EALGVSTRQMMESAGRALAETALRK---SPKNVLILCGRGNNGGDGFVAARHLARH---TDCSCISVSGER 91
Cdd:COG0062    9 MRALDRAAiEALGIPGLVLMERAGRAVARAIRRRfpsAARRVLVLCGPGNNGGDGLVAARLLAEAgynVTVFLLGDPEKL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  92 KGDSMANLRALRACGIPLHEVSCREDvyalshLFRSADLILDCLLGTGAGGSLREPIASCVALADDSPAYILSADLPT-- 169
Cdd:COG0062   89 SGDAAANLERLKAAGIPILELDDELP------ELAEADLIVDALFGTGLSRPLRGPYAELIEAINASGAPVLAVDIPSgl 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 170 ---------PGIPADAILAFHKSK-GVATA----------ITDIGIPIEAECFTGPGDLLT--------IPKKAENAHKG 221
Cdd:COG0062  163 dadtgevlgAAVRADLTVTFGAPKpGLLLGpgrdycgelvVADIGIGIPAAAEAPAALLLLadllalllPPRRRSHHKGG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 222 HGGRVLVVGGGPYQGAPYLAGLAALRAGADIVFVASPNALDCPDLIHIPLSGRIIGEEESGQLIRAAREADVVVIGPGLG 301
Cdd:COG0062  243 GGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAALLAALPEAMALALDDDEELLLLLAAAVVVAGGGGGGG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 302 ADSHDLILRVAEASRRAV-----------IDADALRLPLPKAGETIYTPHSREFARAFDEELSGDPEKDATVVRDACPES 370
Cdd:COG0062  323 GGAGGGLLLLLLLLLLLLvllaaalllllALAAALLLLLLLPPPLAAALLLLRLLTELLELRAAAAALLAAAAAAAAVAA 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 371 ASILLKGETDIISDGRRVRFNRTGVPAMTVGGTGDILAGVAAALLCRMPAFEAAAVAAYATGRAGEEAAQSIGDGLIASD 450
Cdd:COG0062  403 AAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGLLAGAAAAAAAAAAAAAAAAAAAAAAAALAAALLAAA 482

                        490
                 ....*....|..
gi 973165480 451 LLLFIAQILYGD 462
Cdd:COG0062  483 AALIALLLAAAL 494
 
Name Accession Description Interval E-value
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 19-462 6.08e-40

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 150.02  E-value: 6.08e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  19 MQAIEKNA-EALGVSTRQMMESAGRALAETALRK---SPKNVLILCGRGNNGGDGFVAARHLARH---TDCSCISVSGER 91
Cdd:COG0062    9 MRALDRAAiEALGIPGLVLMERAGRAVARAIRRRfpsAARRVLVLCGPGNNGGDGLVAARLLAEAgynVTVFLLGDPEKL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  92 KGDSMANLRALRACGIPLHEVSCREDvyalshLFRSADLILDCLLGTGAGGSLREPIASCVALADDSPAYILSADLPT-- 169
Cdd:COG0062   89 SGDAAANLERLKAAGIPILELDDELP------ELAEADLIVDALFGTGLSRPLRGPYAELIEAINASGAPVLAVDIPSgl 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 170 ---------PGIPADAILAFHKSK-GVATA----------ITDIGIPIEAECFTGPGDLLT--------IPKKAENAHKG 221
Cdd:COG0062  163 dadtgevlgAAVRADLTVTFGAPKpGLLLGpgrdycgelvVADIGIGIPAAAEAPAALLLLadllalllPPRRRSHHKGG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 222 HGGRVLVVGGGPYQGAPYLAGLAALRAGADIVFVASPNALDCPDLIHIPLSGRIIGEEESGQLIRAAREADVVVIGPGLG 301
Cdd:COG0062  243 GGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAALLAALPEAMALALDDDEELLLLLAAAVVVAGGGGGGG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 302 ADSHDLILRVAEASRRAV-----------IDADALRLPLPKAGETIYTPHSREFARAFDEELSGDPEKDATVVRDACPES 370
Cdd:COG0062  323 GGAGGGLLLLLLLLLLLLvllaaalllllALAAALLLLLLLPPPLAAALLLLRLLTELLELRAAAAALLAAAAAAAAVAA 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 371 ASILLKGETDIISDGRRVRFNRTGVPAMTVGGTGDILAGVAAALLCRMPAFEAAAVAAYATGRAGEEAAQSIGDGLIASD 450
Cdd:COG0062  403 AAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGLLAGAAAAAAAAAAAAAAAAAAAAAAAALAAALLAAA 482

                        490
                 ....*....|..
gi 973165480 451 LLLFIAQILYGD 462
Cdd:COG0062  483 AALIALLLAAAL 494
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 251-452 8.48e-36

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 132.74  E-value: 8.48e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 251 DIVFVASPNALD------CPDLIHIPLsgriiGEEESGQLIRAAREADVVVIGPGLGADSH--DLILRVAEASRRAVIDA 322
Cdd:cd01171   37 GLVTVATPPEAAaviksySPELMVHPL-----LETDIEELLELLERADAVVIGPGLGRDEEaaEILEKALAKDKPLVLDA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 323 DALRL------PLPKAGETIYTPHSREFARAFDEELSGDPEKDATVVRDACPES-ASILLKGETDIISDGR-RVRFNRTG 394
Cdd:cd01171  112 DALNLladepsLIKRYGPVVLTPHPGEFARLLGALVEEIQADRLAAAREAAAKLgATVVLKGAVTVIADPDgRVYVNPTG 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 973165480 395 VPAMTVGGTGDILAGVAAALLCR-MPAFEAAAVAAYATGRAGEEAAQSIGDGLIASDLL 452
Cdd:cd01171  192 NPGLATGGSGDVLAGIIAALLAQgLSPLEAAALAVYLHGLAGDLAAKKKGAGLTAADLV 250
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 200-459 1.17e-32

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 124.80  E-value: 1.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  200 ECFTGPGDLLTIPKKAENAHKGHGGRVLVVG-GGPYQGAPYLAGLAALRAGADIVFVASP------NALDCPDLIHIPLS 272
Cdd:TIGR00196   1 ETFLGEGDLLTLPLRDPNSHKGQYGRVLIIGgSDDYSGAPLLAALAALRAGAGLVTVAAPenvitlINSVSPELIVHRLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  273 GRIIGEEESgqliraAREADVVVIGPGLGADS--HDLILRVAEASRRAVIDADALRL---PLPKAGETIYTPHSREFARA 347
Cdd:TIGR00196  81 WKVDEDEEL------LERYDVVVIGPGLGQDPsfKKAVEEVLELDKPVVLDADALNLltyNQKREGEVILTPHPGEFKRL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  348 FDEelSGDPEKDATVVRDACPE-SASILLKGETDIISDGR-RVRFNRTGVPAMTVGGTGDILAGVAAALLC-RMPAFEAA 424
Cdd:TIGR00196 155 LGV--NEIQGDRLEAAQDIAQKlQAVVVLKGAADVIAAPDgDLWINKTGNAALAKGGTGDVLAGLIGGLLAqNLDPFDAA 232

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 973165480  425 AVAAYATGRAGEEAAQSIGD-GLIASDLLLFIAQIL 459
Cdd:TIGR00196 233 CNAAFAHGLAGDLALKNHGAyGLTALDLIEKIPRVC 268
YjeF_N pfam03853
YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a ...
 35-175 1.56e-30

YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.


Pssm-ID: 427546 [Multi-domain]  Cd Length: 168  Bit Score: 115.79  E-value: 1.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480   35 QMMESAGRALAETALRK---SPKNVLILCGRGNNGGDGFVAARHLARH---TDCSCISVSGERKGDSMANLRALRACGIP 108
Cdd:pfam03853   3 VLMENAGRAAARVLKALlspAGPKVLILCGPGNNGGDGLAAARHLANRgakVTVLLLGPEEKLSEDARRQLDLFKKLGGK 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 973165480  109 LHEVSCREDVYALSHlfrSADLILDCLLGTGAGGSLREPIASCVALADDSPAYILSADLPTpGIPAD 175
Cdd:pfam03853  83 IVTDNPDEDLEKLLS---PVDLIIDALLGTGLSGPLRGEYAALIEWINQSGAPVLAVDIPS-GLDAD 145
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 13-452 5.95e-23

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 101.29  E-value: 5.95e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  13 PIDILRmQAIEKNAEALGVSTRQMMESAGRALAETALRKSP--KNVLILCGRGNNGGDGFVAARhLARHT--DCSCISVS 88
Cdd:PRK10565  19 PADDIR-RGEREAADALGLTLYELMLRAGEAAFQVARSAYPdaRHWLVLCGHGNNGGDGYVVAR-LAQAAgiDVTLLAQE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  89 GERKGDSMANL--RALRACGIPLHEVSCR--EDVyalshlfrsaDLILDCLLGTGAGGSLREPIASCVALADDSPAYILS 164
Cdd:PRK10565  97 SDKPLPEEAALarEAWLNAGGEIHAADIVwpESV----------DLIVDALLGTGLRQAPREPYAALIDQANAHPAPVVA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 165 ADLP---------TPG--IPADAILAF--------------------HKSKGVATAITDIGIPIEAECFTGPGDLLTiPK 213
Cdd:PRK10565 167 LDIPsgllaetgaTPGavINADHTVTFialkpglltgkardvvgqlhFDSLGLDSWLAGQEAPIQRFDAEQLSQWLK-PR 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 214 KAeNAHKGHGGRVLVVG-GGPYQGAPYLAGLAALRAGADIVFVaspnaLDCPDLIHIPLSGR--IIGEEESGQLIRAARE 290
Cdd:PRK10565 246 RP-TSHKGDHGRLLIIGgDHGTAGAIRMAGEAALRSGAGLVRV-----LTRSENIAPLLTARpeLMVHELTPDSLEESLE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 291 -ADVVVIGPGLGADS-HDLILRVAEASRRAVI-DADALRL----PLpKAGETIYTPHSREFARAFDEELSgDPEKD--AT 361
Cdd:PRK10565 320 wADVVVIGPGLGQQEwGKKALQKVENFRKPMLwDADALNLlainPD-KRHNRVITPHPGEAARLLGCSVA-EIESDrlLS 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 362 VVRDACPESASILLKGE-TDIISDGRRVRFNRTGVPAMTVGGTGDILAGVAAALLC-RMPAFEAAAVAAYATGRAGEEAA 439
Cdd:PRK10565 398 ARRLVKRYGGVVVLKGAgTVIAAEPDALAIIDVGNAGMASGGMGDVLSGIIGALLGqKLSPYDAACAGCVAHGAAADVLA 477

                        490
                 ....*....|....
gi 973165480 440 QSIGD-GLIASDLL 452
Cdd:PRK10565 478 ARFGTrGMLATDLF 491
 
Name Accession Description Interval E-value
Nnr1 COG0062
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and ...
 19-462 6.08e-40

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain [Nucleotide transport and metabolism];


Pssm-ID: 439832 [Multi-domain]  Cd Length: 499  Bit Score: 150.02  E-value: 6.08e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  19 MQAIEKNA-EALGVSTRQMMESAGRALAETALRK---SPKNVLILCGRGNNGGDGFVAARHLARH---TDCSCISVSGER 91
Cdd:COG0062    9 MRALDRAAiEALGIPGLVLMERAGRAVARAIRRRfpsAARRVLVLCGPGNNGGDGLVAARLLAEAgynVTVFLLGDPEKL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  92 KGDSMANLRALRACGIPLHEVSCREDvyalshLFRSADLILDCLLGTGAGGSLREPIASCVALADDSPAYILSADLPT-- 169
Cdd:COG0062   89 SGDAAANLERLKAAGIPILELDDELP------ELAEADLIVDALFGTGLSRPLRGPYAELIEAINASGAPVLAVDIPSgl 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 170 ---------PGIPADAILAFHKSK-GVATA----------ITDIGIPIEAECFTGPGDLLT--------IPKKAENAHKG 221
Cdd:COG0062  163 dadtgevlgAAVRADLTVTFGAPKpGLLLGpgrdycgelvVADIGIGIPAAAEAPAALLLLadllalllPPRRRSHHKGG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 222 HGGRVLVVGGGPYQGAPYLAGLAALRAGADIVFVASPNALDCPDLIHIPLSGRIIGEEESGQLIRAAREADVVVIGPGLG 301
Cdd:COG0062  243 GGGVLVIGGGGGGGGAAAAAAAAAAAAGGGLVVLAVPPAAAAALLAALPEAMALALDDDEELLLLLAAAVVVAGGGGGGG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 302 ADSHDLILRVAEASRRAV-----------IDADALRLPLPKAGETIYTPHSREFARAFDEELSGDPEKDATVVRDACPES 370
Cdd:COG0062  323 GGAGGGLLLLLLLLLLLLvllaaalllllALAAALLLLLLLPPPLAAALLLLRLLTELLELRAAAAALLAAAAAAAAVAA 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 371 ASILLKGETDIISDGRRVRFNRTGVPAMTVGGTGDILAGVAAALLCRMPAFEAAAVAAYATGRAGEEAAQSIGDGLIASD 450
Cdd:COG0062  403 AAVVAGAAGVVVVAAAGGGGGGGGGGGGGGGGGGGGGGGGGGGLLAGAAAAAAAAAAAAAAAAAAAAAAAALAAALLAAA 482

                        490
                 ....*....|..
gi 973165480 451 LLLFIAQILYGD 462
Cdd:COG0062  483 AALIALLLAAAL 494
Nnr2 COG0063
NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport ...
 251-459 1.32e-36

NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain [Nucleotide transport and metabolism];


Pssm-ID: 439833  Cd Length: 280  Bit Score: 135.64  E-value: 1.32e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 251 DIVFVASP------NALDCPDLIHIPLsgriigeEESGQLIRAAREADVVVIGPGLG--ADSHDLILRVAEAS-RRAVID 321
Cdd:COG0063   55 GLVTVAVPesaapaVAAALPELMVIPL-------PEEDELLELLERADAVVIGPGLGrdEETRELLRALLEAAdKPLVLD 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 322 ADAL-------RLPLPKAGETIYTPHSREFARAFDEELSGDPEKDATVVRDACPES-ASILLKGETDIISDG-RRVRFNR 392
Cdd:COG0063  128 ADALnllaedpELLAALPAPTVLTPHPGEFARLLGCSVAEIQADRLEAAREAAKRYgAVVVLKGAGTVIAAPdGRVYINP 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973165480 393 TGVPAMTVGGTGDILAGVAAALLCR-MPAFEAAAVAAYATGRAGEEAAQSIGDGLIASDLLLFIAQIL 459
Cdd:COG0063  208 TGNPGLATAGSGDVLAGIIAGLLAQgLDPFEAAAAGVYLHGLAGDLAAEERGRGLLASDLIEALPAAL 275
YXKO-related cd01171
B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of ...
 251-452 8.48e-36

B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.


Pssm-ID: 238576  Cd Length: 254  Bit Score: 132.74  E-value: 8.48e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 251 DIVFVASPNALD------CPDLIHIPLsgriiGEEESGQLIRAAREADVVVIGPGLGADSH--DLILRVAEASRRAVIDA 322
Cdd:cd01171   37 GLVTVATPPEAAaviksySPELMVHPL-----LETDIEELLELLERADAVVIGPGLGRDEEaaEILEKALAKDKPLVLDA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 323 DALRL------PLPKAGETIYTPHSREFARAFDEELSGDPEKDATVVRDACPES-ASILLKGETDIISDGR-RVRFNRTG 394
Cdd:cd01171  112 DALNLladepsLIKRYGPVVLTPHPGEFARLLGALVEEIQADRLAAAREAAAKLgATVVLKGAVTVIADPDgRVYVNPTG 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 973165480 395 VPAMTVGGTGDILAGVAAALLCR-MPAFEAAAVAAYATGRAGEEAAQSIGDGLIASDLL 452
Cdd:cd01171  192 NPGLATGGSGDVLAGIIAALLAQgLSPLEAAALAVYLHGLAGDLAAKKKGAGLTAADLV 250
yjeF_cterm TIGR00196
yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length ...
 200-459 1.17e-32

yjeF C-terminal region, hydroxyethylthiazole kinase-related; E. coli yjeF has full-length orthologs in a number of species, all of unknown function. However, yeast YNL200C is homologous and corresponds to the N-terminal region while yeast YKL151C and B. subtilis yxkO correspond to this C-terminal region only. The present model may hit hydroxyethylthiazole kinase, an enzyme associated with thiamine biosynthesis. [Unknown function, General]


Pssm-ID: 272955  Cd Length: 270  Bit Score: 124.80  E-value: 1.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  200 ECFTGPGDLLTIPKKAENAHKGHGGRVLVVG-GGPYQGAPYLAGLAALRAGADIVFVASP------NALDCPDLIHIPLS 272
Cdd:TIGR00196   1 ETFLGEGDLLTLPLRDPNSHKGQYGRVLIIGgSDDYSGAPLLAALAALRAGAGLVTVAAPenvitlINSVSPELIVHRLM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  273 GRIIGEEESgqliraAREADVVVIGPGLGADS--HDLILRVAEASRRAVIDADALRL---PLPKAGETIYTPHSREFARA 347
Cdd:TIGR00196  81 WKVDEDEEL------LERYDVVVIGPGLGQDPsfKKAVEEVLELDKPVVLDADALNLltyNQKREGEVILTPHPGEFKRL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  348 FDEelSGDPEKDATVVRDACPE-SASILLKGETDIISDGR-RVRFNRTGVPAMTVGGTGDILAGVAAALLC-RMPAFEAA 424
Cdd:TIGR00196 155 LGV--NEIQGDRLEAAQDIAQKlQAVVVLKGAADVIAAPDgDLWINKTGNAALAKGGTGDVLAGLIGGLLAqNLDPFDAA 232

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 973165480  425 AVAAYATGRAGEEAAQSIGD-GLIASDLLLFIAQIL 459
Cdd:TIGR00196 233 CNAAFAHGLAGDLALKNHGAyGLTALDLIEKIPRVC 268
YjeF_N pfam03853
YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a ...
 35-175 1.56e-30

YjeF-related protein N-terminus; YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.


Pssm-ID: 427546 [Multi-domain]  Cd Length: 168  Bit Score: 115.79  E-value: 1.56e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480   35 QMMESAGRALAETALRK---SPKNVLILCGRGNNGGDGFVAARHLARH---TDCSCISVSGERKGDSMANLRALRACGIP 108
Cdd:pfam03853   3 VLMENAGRAAARVLKALlspAGPKVLILCGPGNNGGDGLAAARHLANRgakVTVLLLGPEEKLSEDARRQLDLFKKLGGK 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 973165480  109 LHEVSCREDVYALSHlfrSADLILDCLLGTGAGGSLREPIASCVALADDSPAYILSADLPTpGIPAD 175
Cdd:pfam03853  83 IVTDNPDEDLEKLLS---PVDLIIDALLGTGLSGPLRGEYAALIEWINQSGAPVLAVDIPS-GLDAD 145
yjeF_nterm TIGR00197
yjeF N-terminal region; The protein region corresponding to this model shows no clear homology ...
 19-196 2.96e-30

yjeF N-terminal region; The protein region corresponding to this model shows no clear homology to any protein of known function. This model is built on yeast protein YNL200C and the N-terminal regions of E. coli yjeF and its orthologs in various species. The C-terminal region of yjeF and its orthologs shows similarity to hydroxyethylthiazole kinase (thiM) and other enzymes involved in thiamine biosynthesis. Yeast YKL151C and B. subtilis yxkO match the yjeF C-terminal domain but lack this region. [Unknown function, General]


Pssm-ID: 272956 [Multi-domain]  Cd Length: 205  Bit Score: 116.36  E-value: 2.96e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480   19 MQAIEKNAEALGVSTRQMMESAGRALAETALRKSP--KNVLILCGRGNNGGDGFVAARHLARH-TDCSCISVSGERKGDS 95
Cdd:TIGR00197   9 MAIDKENAEYLGLTLDLLMENAGKAVAQAVLQAYPlaGHVIIFCGPGNNGGDGFVVARHLKGFgVEVFLLKKEKRIECTE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480   96 MA--NLRALRACGIPLHEVSCREDVyalshlfrSADLILDCLLGTGAGGSLREPIASCVALADDSPAYILSADLPT---- 169
Cdd:TIGR00197  89 QAevNLKALKVGGISIDEGNLVKPE--------DCDVIIDAILGTGFKGKLREPFKTIVESINELPAPIVSVDIPSgldv 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 973165480  170 -------PGIPADAILAFHKSK-GVATA---------ITDIGIP 196
Cdd:TIGR00197 161 dtgaiegPAVNADLTITFHAIKpCLLSDradvtgelkVGGIGIP 204
PRK10565 PRK10565
putative carbohydrate kinase; Provisional
 13-452 5.95e-23

putative carbohydrate kinase; Provisional


Pssm-ID: 182554 [Multi-domain]  Cd Length: 508  Bit Score: 101.29  E-value: 5.95e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  13 PIDILRmQAIEKNAEALGVSTRQMMESAGRALAETALRKSP--KNVLILCGRGNNGGDGFVAARhLARHT--DCSCISVS 88
Cdd:PRK10565  19 PADDIR-RGEREAADALGLTLYELMLRAGEAAFQVARSAYPdaRHWLVLCGHGNNGGDGYVVAR-LAQAAgiDVTLLAQE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  89 GERKGDSMANL--RALRACGIPLHEVSCR--EDVyalshlfrsaDLILDCLLGTGAGGSLREPIASCVALADDSPAYILS 164
Cdd:PRK10565  97 SDKPLPEEAALarEAWLNAGGEIHAADIVwpESV----------DLIVDALLGTGLRQAPREPYAALIDQANAHPAPVVA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 165 ADLP---------TPG--IPADAILAF--------------------HKSKGVATAITDIGIPIEAECFTGPGDLLTiPK 213
Cdd:PRK10565 167 LDIPsgllaetgaTPGavINADHTVTFialkpglltgkardvvgqlhFDSLGLDSWLAGQEAPIQRFDAEQLSQWLK-PR 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 214 KAeNAHKGHGGRVLVVG-GGPYQGAPYLAGLAALRAGADIVFVaspnaLDCPDLIHIPLSGR--IIGEEESGQLIRAARE 290
Cdd:PRK10565 246 RP-TSHKGDHGRLLIIGgDHGTAGAIRMAGEAALRSGAGLVRV-----LTRSENIAPLLTARpeLMVHELTPDSLEESLE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 291 -ADVVVIGPGLGADS-HDLILRVAEASRRAVI-DADALRL----PLpKAGETIYTPHSREFARAFDEELSgDPEKD--AT 361
Cdd:PRK10565 320 wADVVVIGPGLGQQEwGKKALQKVENFRKPMLwDADALNLlainPD-KRHNRVITPHPGEAARLLGCSVA-EIESDrlLS 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480 362 VVRDACPESASILLKGE-TDIISDGRRVRFNRTGVPAMTVGGTGDILAGVAAALLC-RMPAFEAAAVAAYATGRAGEEAA 439
Cdd:PRK10565 398 ARRLVKRYGGVVVLKGAgTVIAAEPDALAIIDVGNAGMASGGMGDVLSGIIGALLGqKLSPYDAACAGCVAHGAAADVLA 477

                        490
                 ....*....|....
gi 973165480 440 QSIGD-GLIASDLL 452
Cdd:PRK10565 478 ARFGTrGMLATDLF 491
Carb_kinase pfam01256
Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also ...
 233-452 2.80e-19

Carbohydrate kinase; This family is related to pfam02110 and pfam00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).


Pssm-ID: 396007  Cd Length: 242  Bit Score: 86.65  E-value: 2.80e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  233 PYQGAPYLAGLAALRAGADIVFVA------SPNALDCPDLIHIPLSgriigeeESGQLIRAAREADVVVIGPGLGAD--S 304
Cdd:pfam01256   9 DYTGAPLLAALAALRSGAGLVSVAtdseaiAVLKSPLPEVMVHPLP-------ETSSILEKLSRYDAVVIGPGLGRDekG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  305 HDLILRVAEASRRAVIDADALRL-------PLPKaGETIYTPHSREFARafdeeLSGDPEKDATVVRDACPE-----SAS 372
Cdd:pfam01256  82 KAALEEVLAKDCPLVIDADALNLlainnekPARE-GPTVLTPHPGEFER-----LCGLAGILGDDRLEAARElaqklNGT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  373 ILLKGETDII-SDGRRVRFNRTGVPAMTVGGTGDILAGVAAALLCR-MPAFEAAAVAAYATGRAGEEAAQSIGDGLIASD 450
Cdd:pfam01256 156 ILLKGNVTVIaAPGGEVWINSTGNSALAKGGSGDVLAGLIGGLLAQnEDPYDAAIAAAWLHGAASDLAAENHGVYMLPTL 235


                  ..
gi 973165480  451 LL 452
Cdd:pfam01256 236 LS 237
PLN03050 PLN03050
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 30-169 4.93e-15

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215551 [Multi-domain]  Cd Length: 246  Bit Score: 74.53  E-value: 4.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  30 GVSTRQMMESAG----RALAETALRKSPKN-------VLILCGRGNNGGDGFVAARHLArHTDCSCISVSGERKGDSMAN 98
Cdd:PLN03050  26 GFSLEQLMELAGlsvaEAVYEVADGEKASNppgrhprVLLVCGPGNNGGDGLVAARHLA-HFGYEVTVCYPKQSSKPHYE 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 973165480  99 --LRALRACGIPLheVSCREDVYALSHLFRSA-DLILDCLLGTGAGGSLREPIASCVALAD---DSPAYILSADLPT 169
Cdd:PLN03050 105 nlVTQCEDLGIPF--VQAIGGTNDSSKPLETTyDVIVDAIFGFSFHGAPRAPFDTLLAQMVqqqKSPPPIVSVDVPS 179
PLN03049 PLN03049
pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional
 7-169 1.20e-11

pyridoxine (pyridoxamine) 5'-phosphate oxidase; Provisional


Pssm-ID: 215550 [Multi-domain]  Cd Length: 462  Bit Score: 66.41  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480   7 AQAEEEPIDILRMQAieknaeaLGVSTRQMMESAGRALAETALRKSPKN----VLILCGRGNNGGDGFVAARHLaRHTDC 82
Cdd:PLN03049  16 SQREAIAIDEHLMGP-------LGFSVDQLMELAGLSVASAIAEVYSPSeyrrVLALCGPGNNGGDGLVAARHL-HHFGY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  83 SCISVSGERKGDSMAN--LRALRACGIPLheVSCREDVYALSHLFrsaDLILDCLLGTGAGGSLREPIASCVA--LADDS 158
Cdd:PLN03049  88 KPSICYPKRTDKPLYNglVTQLESLSVPF--LSVEDLPSDLSSQF---DIVVDAMFGFSFHGAPRPPFDDLIQklVRAAG 162

                        170
                 ....*....|.
gi 973165480 159 PAYILSADLPT 169
Cdd:PLN03049 163 PPPIVSVDIPS 173
PLN02918 PLN02918
pyridoxine (pyridoxamine) 5'-phosphate oxidase
 29-169 1.19e-08

pyridoxine (pyridoxamine) 5'-phosphate oxidase


Pssm-ID: 215496 [Multi-domain]  Cd Length: 544  Bit Score: 57.25  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165480  29 LGVSTRQMMESAG----RALAETALRKSPKNVLILCGRGNNGGDGFVAARHLaRHTDCSCISVSGERKGDSMAN--LRAL 102
Cdd:PLN02918 107 LGFSVDQLMELAGlsvaASIAEVYKPGEYSRVLAICGPGNNGGDGLVAARHL-HHFGYKPFVCYPKRTAKPLYTglVTQL 185

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 973165480 103 RACGIPLHEVscrEDVyaLSHLFRSADLILDCLLGTGAGGSLREP----IASCVALAD-----DSPAyILSADLPT 169
Cdd:PLN02918 186 ESLSVPFVSV---EDL--PADLSKDFDIIVDAMFGFSFHGAPRPPfddlIRRLVSLQNyeqtlKHPV-IVSVDIPS 255
PRK09355 PRK09355
hydroxyethylthiazole kinase; Validated
 370-413 1.27e-04

hydroxyethylthiazole kinase; Validated


Pssm-ID: 236477 [Multi-domain]  Cd Length: 263  Bit Score: 43.64  E-value: 1.27e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 973165480 370 SASILLKGETDIISDGRRVRFNRTGVPAMT-VGGTGDILAGVAAA 413
Cdd:PRK09355 157 GTVVVVTGEVDYITDGERVVSVHNGHPLMTkVTGTGCLLSAVVAA 201
THZ_kinase cd01170
4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the ...
 366-415 1.63e-04

4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine and 1-deoxy-D-xylulose-5-phosphate.


Pssm-ID: 238575 [Multi-domain]  Cd Length: 242  Bit Score: 42.91  E-value: 1.63e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 973165480 366 ACPESASILLKGETDIISDGRRVRFNRTGVPAMT-VGGTGDILAGVAAALL 415
Cdd:cd01170  149 ARKYGAVVVVTGEVDYITDGERVVVVKNGHPLLTkITGTGCLLGAVIAAFL 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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