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Conserved domains on  [gi|973165467|gb|KUL05240|]
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Digeranylgeranylglyceryl phosphate synthase [Methanomicrobiales archaeon 53_19]

Protein Classification

UbiA prenyltransferase family protein( domain architecture ID 91)

UbiA prenyltransferase family protein, an aromatic prenyltransferase, plays an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PT_UbiA super family cl00337
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 1-276 1.05e-88

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


The actual alignment was detected with superfamily member PRK12882:

Pssm-ID: 469727  Cd Length: 276  Bit Score: 265.30  E-value: 1.05e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   1 MHLPGIIRIIRPANATISGATAILAYFIATGTVIPEVLLLAAAA--LLITGAGNTINDACDAAIDAINRPDRPIPSGELS 78
Cdd:PRK12882   2 MTVRGYLELTRPVNAVVAGVAAFIGAFIAGGILSSPSLTGLAFAavFLATGAGNAINDYFDREIDRINRPDRPIPSGAVS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  79 VKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITVP 158
Cdd:PRK12882  82 PRGALAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLYAETLKGTPGLGNASVAYLTGSTFLFGGAAVGTEGLLALLV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 159 LAGITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPFL--WWGLPYLVGIVILDSAI 236
Cdd:PRK12882 162 LFALAALATLAREIIKDVEDIEGDRAEGARTLPILIGVRKALYVAAAFLLVAVAASPLPYLlsTFGLWYLVLVAPADLVM 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 973165467 237 LRSVWPATRCTTPAcirnlKITTQLKYMMYIALLIFLVAS 276
Cdd:PRK12882 242 LAAAYRSLKKTDPT-----ASQKLLKYGMFLALAAFIVGR 276
 
Name Accession Description Interval E-value
ubiA PRK12882
prenyltransferase; Reviewed
 1-276 1.05e-88

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 265.30  E-value: 1.05e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   1 MHLPGIIRIIRPANATISGATAILAYFIATGTVIPEVLLLAAAA--LLITGAGNTINDACDAAIDAINRPDRPIPSGELS 78
Cdd:PRK12882   2 MTVRGYLELTRPVNAVVAGVAAFIGAFIAGGILSSPSLTGLAFAavFLATGAGNAINDYFDREIDRINRPDRPIPSGAVS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  79 VKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITVP 158
Cdd:PRK12882  82 PRGALAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLYAETLKGTPGLGNASVAYLTGSTFLFGGAAVGTEGLLALLV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 159 LAGITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPFL--WWGLPYLVGIVILDSAI 236
Cdd:PRK12882 162 LFALAALATLAREIIKDVEDIEGDRAEGARTLPILIGVRKALYVAAAFLLVAVAASPLPYLlsTFGLWYLVLVAPADLVM 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 973165467 237 LRSVWPATRCTTPAcirnlKITTQLKYMMYIALLIFLVAS 276
Cdd:PRK12882 242 LAAAYRSLKKTDPT-----ASQKLLKYGMFLALAAFIVGR 276
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 5-273 9.12e-64

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 201.19  E-value: 9.12e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   5 GIIRIIRPANATISGATAILAYFIATGTV----IPEVLLLAAAALLITGAGNTINDACDAAIDAINRPDRPIPSGELSVK 80
Cdd:cd13961    1 AYLELIRPPNLLMAALAQYLGALFALGPLlslnDLELLLLFLSVFLIAAAGYIINDYFDVEIDRINKPDRPIPSGRISRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  81 TAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVdGLIITVPLA 160
Cdd:cd13961   81 EALILSILLNALGLILAFLLSPLALLIALLNSLLLWLYSHKLKRTPLIGNLLVALLTGLPFLFGGLAAGN-LLLIILLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 161 GITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPFL--WWGLPYLVGIVILDSAILR 238
Cdd:cd13961  160 LFAFLITLGREIVKDIEDVEGDRAEGARTLPIVYGIKKAKKIAALLLLLAILLSPLPYLlgGLGILYLILIIIADLLFLY 239

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 973165467 239 SVWPATRCTTPAcirnLKITTQLKYMMYIALLIFL 273
Cdd:cd13961  240 SAIRLAKSPKDY----SKLSKLLKLAMLLGLLAFL 270
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 6-275 1.46e-40

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 141.91  E-value: 1.46e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   6 IIRIIRPANATISGATAILAYFIATGTVIP--EVLLLAAAALLITGAGNTINDACDAAIDAIN--RPDRPIPSGELSVKT 81
Cdd:COG0382    6 LLRLDRPIGILLLLWPTLWALFLAAGGLPDllLLLLAVLGTVLMRSAGYVINDYFDREIDRINerKPNRPLASGRISLRE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  82 AYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITVPLAG 161
Cdd:COG0382   86 ALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLFLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPLSAWLLAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 162 ITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPFLWWGL--PYLVGIVILDSAILRS 239
Cdd:COG0382  166 AAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGVLYALAVLLLLLLGLLAGLglLYLLGLLAALLLLYLS 245

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 973165467 240 VWPATRcttPACIRNLKITTQLKYMMYIALLIFLVA 275
Cdd:COG0382  246 QLWLLR---PRKKDPARALKLFKLNMLLGLLLFLGI 278
UbiA pfam01040
UbiA prenyltransferase family;
20-241 8.64e-25

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 99.61  E-value: 8.64e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   20 ATAILAYFIATGTVIP--EVLLLAAAALLITGAGNTINDACDAAIDAINR--PDRPIPSGELSVKTAYLYAALLFILGLS 95
Cdd:pfam01040   3 IPALAGLALAAGGVPDllLLLLALLGTVLARAAANALNDYYDRDIDAIMPrtPNRPLPSGRISPREALIFALVLLALGLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   96 AAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITVPLAGITLFGTLAREIVKD 175
Cdd:pfam01040  83 LLLLLNPLTALLGLAALLLYVLYTLRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIALAND 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973165467  176 AEDIDGDAAGGATTLPMAIGISRS--GTIAFGSAIIAVIVSFIPFLWWGLPYLVGIVILDSAILRSVW 241
Cdd:pfam01040 163 LRDREDDRKAGIKTLPVVLGRKAAriLLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAAR 230
chlor_syn_BchG TIGR01476
bacteriochlorophyll/chlorophyll synthetase; This model describes a subfamily of a large family ...
 47-232 8.13e-16

bacteriochlorophyll/chlorophyll synthetase; This model describes a subfamily of a large family of polyprenyltransferases (pfam01040) that also includes 4-hydroxybenzoate octaprenyltransferase and protoheme IX farnesyltransferase (heme O synthase). Members of this family are found exclusively in photosynthetic organisms, including a single copy in Arabidopsis thaliana. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 130541  Cd Length: 283  Bit Score: 75.58  E-value: 8.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   47 ITGAGNTINDACDAAIDAINRPDRPIPSGELSVKTAYLYAALLFILGLSAA-FFTNPLCLAIAIINSILLLLYAR---IL 122
Cdd:TIGR01476  50 GTGFSQSINDYFDRDVDAINEPQRPIPSGIISLREVRWNWLVLTVAGLLVAlVLGNWLIVLFTVVGIVLAVIYSMppiKL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  123 KGTVLFGNIAVA--YLSGSIFLFGGALAGVDGLIITVPLagITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSG 200
Cdd:TIGR01476 130 KRNGWLGPPAVGlsYEGLPWMAGHAIFAPLTWQSVVVAL--IYSLGAHGIMTLNDFKSVEGDRQLGLRSLPVMIGVKRAA 207

                         170       180       190
                  ....*....|....*....|....*....|..
gi 973165467  201 TIAFGSAIIAVIVSFIPFLWWGLPYLVGIVIL 232
Cdd:TIGR01476 208 IVAVTTINVFQAMVIGLLLIWGQPWVATIVFL 239
prenyl_rel_EboC NF035940
UbiA-like protein EboC;
7-131 6.94e-14

UbiA-like protein EboC;


Pssm-ID: 468273  Cd Length: 292  Bit Score: 70.26  E-value: 6.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   7 IRIIRPANaTISGATAILAYFIATGTVIPEVLLLAAAALLI---------TGAGNTINDACDAAIDAINRPDRPIPSGEL 77
Cdd:NF035940   3 LQLMRPAN-IVTAWADILAGFAISGFLTLTWSSAPNDISLIwlllatiglYGGGVVFNDVFDAELDAVERPERPIPSGRV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 973165467  78 SVKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNI 131
Cdd:NF035940  82 SKQAALLLGSLLLLIGILAAFQVSLLSGVIALAIALAALLYDRFGKHHAIFGPL 135
 
Name Accession Description Interval E-value
ubiA PRK12882
prenyltransferase; Reviewed
 1-276 1.05e-88

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 265.30  E-value: 1.05e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   1 MHLPGIIRIIRPANATISGATAILAYFIATGTVIPEVLLLAAAA--LLITGAGNTINDACDAAIDAINRPDRPIPSGELS 78
Cdd:PRK12882   2 MTVRGYLELTRPVNAVVAGVAAFIGAFIAGGILSSPSLTGLAFAavFLATGAGNAINDYFDREIDRINRPDRPIPSGAVS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  79 VKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITVP 158
Cdd:PRK12882  82 PRGALAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLYAETLKGTPGLGNASVAYLTGSTFLFGGAAVGTEGLLALLV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 159 LAGITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPFL--WWGLPYLVGIVILDSAI 236
Cdd:PRK12882 162 LFALAALATLAREIIKDVEDIEGDRAEGARTLPILIGVRKALYVAAAFLLVAVAASPLPYLlsTFGLWYLVLVAPADLVM 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 973165467 237 LRSVWPATRCTTPAcirnlKITTQLKYMMYIALLIFLVAS 276
Cdd:PRK12882 242 LAAAYRSLKKTDPT-----ASQKLLKYGMFLALAAFIVGR 276
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 5-273 9.12e-64

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 201.19  E-value: 9.12e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   5 GIIRIIRPANATISGATAILAYFIATGTV----IPEVLLLAAAALLITGAGNTINDACDAAIDAINRPDRPIPSGELSVK 80
Cdd:cd13961    1 AYLELIRPPNLLMAALAQYLGALFALGPLlslnDLELLLLFLSVFLIAAAGYIINDYFDVEIDRINKPDRPIPSGRISRR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  81 TAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVdGLIITVPLA 160
Cdd:cd13961   81 EALILSILLNALGLILAFLLSPLALLIALLNSLLLWLYSHKLKRTPLIGNLLVALLTGLPFLFGGLAAGN-LLLIILLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 161 GITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPFL--WWGLPYLVGIVILDSAILR 238
Cdd:cd13961  160 LFAFLITLGREIVKDIEDVEGDRAEGARTLPIVYGIKKAKKIAALLLLLAILLSPLPYLlgGLGILYLILIIIADLLFLY 239

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 973165467 239 SVWPATRCTTPAcirnLKITTQLKYMMYIALLIFL 273
Cdd:cd13961  240 SAIRLAKSPKDY----SKLSKLLKLAMLLGLLAFL 270
PRK09573 PRK09573
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed
 9-276 3.43e-51

(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed


Pssm-ID: 181963  Cd Length: 279  Bit Score: 169.37  E-value: 3.43e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   9 IIRPANATISGATAILAYFIATG--TVIPEVLLLAAAALLITGAGNTINDACDAAIDAINRPDRPIPSGELSVKTAYLYA 86
Cdd:PRK09573   9 LIRPKNCIGASIGAIIGYLIASNfkIDLKGIILAALVVFLVCAGGNVINDIYDIEIDKINKPERPIPSGRISLKEAKIFS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  87 ALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVdgLIITVPLAGITLFG 166
Cdd:PRK09573  89 ITLFIVGLILSIFINIYAFLIALLNSILLYLYAKDLKKTGLIGNLIVAYLTGLSFIFGGLAVFN--VLRIIILFLCAFFS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 167 TLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPFL--WWGLPYLVGIVILDSAILRSVWPAT 244
Cdd:PRK09573 167 TWSREIVKDIEDIEGDLKENVITLPIKYGIKKSWYIAKILLILAIVLSPLPYFlgIFGIYYLIVVIICDILFIIAMLILL 246

                        250       260       270
                 ....*....|....*....|....*....|..
gi 973165467 245 RCTTPACIRnlKITTQLKYMMYIALLIFLVAS 276
Cdd:PRK09573 247 KNPSIEGAS--KASKYLKIIMILGLIAFLIGS 276
ubiA PRK12884
prenyltransferase; Reviewed
 1-276 2.28e-50

prenyltransferase; Reviewed


Pssm-ID: 183812  Cd Length: 279  Bit Score: 167.06  E-value: 2.28e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   1 MHLPGIIRIIRPANATISGATAILAYFIATGTVIP-EVLLLAAAALLITGAGNTINDACDAAIDAINRPDRPIPSGELSV 79
Cdd:PRK12884   2 TKMKAYLELLRPEHGLMAGIAVVLGAIIALGGLPLdEALLGFLTAFFASGSANALNDYFDYEVDRINRPDRPIPSGRISR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  80 KTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGvDGLIITVPL 159
Cdd:PRK12884  82 REALLLAILLFILGLIAAYLISPLAFLVVILVSVLGILYNWKLKEYGLIGNLYVAFLTGMTFIFGGIAVG-ELNEAVILL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 160 AGITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPFL--WWGLPYLVGIVILDSAIL 237
Cdd:PRK12884 161 AAMAFLMTLGREIMKDIEDVEGDRLRGARTLAILYGEKIAGRIAAALFILAVLLSPLPYLfgIFNILYLAPVLVADLIFL 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 973165467 238 RSVWPATRCTTPACIRnlKITTQLKYMMYIALLIFLVAS 276
Cdd:PRK12884 241 YSAYSLLRSQDRETIR--KVRKITLTAMLLALVAFALGA 277
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 6-275 1.46e-40

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 141.91  E-value: 1.46e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   6 IIRIIRPANATISGATAILAYFIATGTVIP--EVLLLAAAALLITGAGNTINDACDAAIDAIN--RPDRPIPSGELSVKT 81
Cdd:COG0382    6 LLRLDRPIGILLLLWPTLWALFLAAGGLPDllLLLLAVLGTVLMRSAGYVINDYFDREIDRINerKPNRPLASGRISLRE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  82 AYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITVPLAG 161
Cdd:COG0382   86 ALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLFLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPLSAWLLAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 162 ITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPFLWWGL--PYLVGIVILDSAILRS 239
Cdd:COG0382  166 AAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGVLYALAVLLLLLLGLLAGLglLYLLGLLAALLLLYLS 245

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 973165467 240 VWPATRcttPACIRNLKITTQLKYMMYIALLIFLVA 275
Cdd:COG0382  246 QLWLLR---PRKKDPARALKLFKLNMLLGLLLFLGI 278
ubiA PRK12883
prenyltransferase UbiA-like protein; Reviewed
 1-276 2.85e-39

prenyltransferase UbiA-like protein; Reviewed


Pssm-ID: 171796  Cd Length: 277  Bit Score: 138.32  E-value: 2.85e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   1 MHLPGIIRIIRPANATISGATAILAYFIATGTvIPEVLLLAAAALLIT---GAGNTINDACDAAIDAINRPDRPIPSGEL 77
Cdd:PRK12883   1 MELKAFIEITRPHNCILAGIVGILGSLVALGG-IPPIKTLILIFLVVYlgcSGGNTINDYFDYEIDKINRPNRPLPRGAM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  78 SVKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITv 157
Cdd:PRK12883  80 SRKAALYYSLLLFAVGLALAYLINIEAFLFALGAYVLMFLYAWKLKPLPFIGNVVVALLTGATPIYGAIAVGRIGLAGY- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 158 pLAGITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPF-LWWGLPYLvGIVILDSAI 236
Cdd:PRK12883 159 -LAICAFLVNVAREIMKDIEDIEGDKAKGAKTLPIIIGKKRAAYIGAIFGVLTVIASFLPVkAGIGLGYL-PIIIVDAII 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 973165467 237 LRSVWPATRctTPACIRNLKITTQLKYMMYIALLIFLVAS 276
Cdd:PRK12883 237 LYAAYLVLR--NPDRETAHKGQKLLKIAIFLAVISFLLGA 274
UbiA pfam01040
UbiA prenyltransferase family;
20-241 8.64e-25

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 99.61  E-value: 8.64e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   20 ATAILAYFIATGTVIP--EVLLLAAAALLITGAGNTINDACDAAIDAINR--PDRPIPSGELSVKTAYLYAALLFILGLS 95
Cdd:pfam01040   3 IPALAGLALAAGGVPDllLLLLALLGTVLARAAANALNDYYDRDIDAIMPrtPNRPLPSGRISPREALIFALVLLALGLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   96 AAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITVPLAGITLFGTLAREIVKD 175
Cdd:pfam01040  83 LLLLLNPLTALLGLAALLLYVLYTLRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIALAND 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 973165467  176 AEDIDGDAAGGATTLPMAIGISRS--GTIAFGSAIIAVIVSFIPFLWWGLPYLVGIVILDSAILRSVW 241
Cdd:pfam01040 163 LRDREDDRKAGIKTLPVVLGRKAAriLLALLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAAR 230
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 7-241 4.26e-24

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 98.19  E-value: 4.26e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   7 IRIIRPANATISGATAILAYFIATGTVIPE---VLLLAAAALLITGAGNTINDACDAAIDAINRPDRPIPSGELSVKTAY 83
Cdd:cd13956    1 LRLMRPYTLLYVLAPALAGAALAGAFAGPLpalLLLALLAVFLGAGAGYALNDYTDRELDAINKPDRPLPSGRLSPRQAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  84 LYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITVPL-AGI 162
Cdd:cd13956   81 AFAAALLLVGLALALALGPLALLLLLAGLLLGLAYSLGLKRLKLGGWGVLGYATGLALLPGLGAVAAGGLVPLALLlALV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 163 TLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVS--FIPFLWWGLPYLVGIVILDSAILRSV 240
Cdd:cd13956  161 FLLLGLGINLYNDLPDVEGDRAAGIRTLPVRLGPRRARRLAAGLLLAALILVvlLAVAGLLGPLALLALLAVALLALRAR 240


                 .
gi 973165467 241 W 241
Cdd:cd13956  241 F 241
PT_UbiA_chlorophyll cd13958
Bacteriochlorophyll/chlorophyll synthetase; Chlorophyll synthase catalyzes the last step of ...
 47-232 2.06e-21

Bacteriochlorophyll/chlorophyll synthetase; Chlorophyll synthase catalyzes the last step of chlorophyll (Chl) biosynthesis, the addition of the tetraprenyl (phytyl or geranylgeranyl) side chain. In plant chloroplast, the chlorophyll synthase is located in thylakoid membrane and has been shown to also have a regulatory or channeling function. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260121  Cd Length: 277  Bit Score: 91.14  E-value: 2.06e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  47 ITGAGNTINDACDAAIDAINRPDRPIPSGELSVKTAYLYAALLFILGLS-AAFFTNPLCLAIAIINSILLLLYAR---IL 122
Cdd:cd13958   48 LTGTSQTINDYYDREVDAINEPYRPIPSGRISEREALWNIWVLLLLSLLvALFLDGPWVFAAAVVGLVLAYIYSApplKL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 123 KGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITV-PLAGITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSGT 201
Cdd:cd13958  128 KQNGWWGNAAVGLSYEGLPWWAGAAAFAGLLTWESlALALLYSIGAHGIMTLNDFKSIEGDRQLGLRSLPVALGVDTAAW 207

                        170       180       190
                 ....*....|....*....|....*....|....
gi 973165467 202 IAFGSAIIAVIVSFIPFLWWGLPY---LVGIVIL 232
Cdd:cd13958  208 IACGVIDVPQLAVAALLLAWGETWyaaVVGALLL 241
PRK07566 PRK07566
chlorophyll synthase ChlG;
48-232 4.87e-18

chlorophyll synthase ChlG;


Pssm-ID: 236052  Cd Length: 314  Bit Score: 82.28  E-value: 4.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  48 TGAGNTINDACDAAIDAINRPDRPIPSGELSVKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYA----RiLK 123
Cdd:PRK07566  78 CGTSQTLNDYFDREVDAINEPYRPIPSGAISLRWVLYLIAVLTVLGLAVAYLLGPWVFLAALLGLFLAWIYSapplR-LK 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 124 GTVLFGNIAVA-------YLSGSIFLFGGALAGVdgliiTVPLAGITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGI 196
Cdd:PRK07566 157 QNGWLGNYAVGlsyeglpWWAGAAAFGAGLPSWP-----IVILALLYSLGAHGIMTLNDFKSVEGDRQLGLRSLPVVFGE 231

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 973165467 197 SRSGTIAFGSAIIAVIVSFIPFLWWGLPYLVGIVIL 232
Cdd:PRK07566 232 KNAARIACVVIDLFQLAVIALLLAWGQPLYAAIVGL 267
chlor_syn_BchG TIGR01476
bacteriochlorophyll/chlorophyll synthetase; This model describes a subfamily of a large family ...
 47-232 8.13e-16

bacteriochlorophyll/chlorophyll synthetase; This model describes a subfamily of a large family of polyprenyltransferases (pfam01040) that also includes 4-hydroxybenzoate octaprenyltransferase and protoheme IX farnesyltransferase (heme O synthase). Members of this family are found exclusively in photosynthetic organisms, including a single copy in Arabidopsis thaliana. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 130541  Cd Length: 283  Bit Score: 75.58  E-value: 8.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   47 ITGAGNTINDACDAAIDAINRPDRPIPSGELSVKTAYLYAALLFILGLSAA-FFTNPLCLAIAIINSILLLLYAR---IL 122
Cdd:TIGR01476  50 GTGFSQSINDYFDRDVDAINEPQRPIPSGIISLREVRWNWLVLTVAGLLVAlVLGNWLIVLFTVVGIVLAVIYSMppiKL 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  123 KGTVLFGNIAVA--YLSGSIFLFGGALAGVDGLIITVPLagITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGISRSG 200
Cdd:TIGR01476 130 KRNGWLGPPAVGlsYEGLPWMAGHAIFAPLTWQSVVVAL--IYSLGAHGIMTLNDFKSVEGDRQLGLRSLPVMIGVKRAA 207

                         170       180       190
                  ....*....|....*....|....*....|..
gi 973165467  201 TIAFGSAIIAVIVSFIPFLWWGLPYLVGIVIL 232
Cdd:TIGR01476 208 IVAVTTINVFQAMVIGLLLIWGQPWVATIVFL 239
PT_UbiA_1 cd13964
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 8-253 3.25e-14

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260127  Cd Length: 282  Bit Score: 71.07  E-value: 3.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   8 RIIRPANATISGATAILAYFIATGTVIP--EVLLLAAAALLITGAGNTINDACDAAIDAINRPDRPIPSGELSVKTAYLY 85
Cdd:cd13964    3 QLVRLPNLFTVPADVLAGAALAGGGLGPvlRLALLLLASVLLYAAGMVLNDVFDAELDARERPERPIPSGRVSRGAALAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  86 AALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVlFGNIAVAYLSGSIFLFGGALAGVDGLIITVPLAG---- 161
Cdd:cd13964   83 GAGLLAAGVALAALVGRLSGLVALLLAAAILLYDAWLKHTP-LGPLLMGLCRGLNLLLGASAAAAGGLGPALLAALalgv 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 162 -ITLFGTLAReivkdaedidGDAAGGATTLPMAIGIsrsgTIAFGSAIIAVIVSFIPFLWWGLPYLVGIVILdsAILRSV 240
Cdd:cd13964  162 yIAGVTYIAR----------GEVHGGPRRLLPLALL----AVLLVIGLALALAAPRGGRVLLALLFLALFAA--WVGRPL 225

                        250
                 ....*....|...
gi 973165467 241 WPATRCTTPACIR 253
Cdd:cd13964  226 LRAYRDPSPPNIG 238
prenyl_rel_EboC NF035940
UbiA-like protein EboC;
7-131 6.94e-14

UbiA-like protein EboC;


Pssm-ID: 468273  Cd Length: 292  Bit Score: 70.26  E-value: 6.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   7 IRIIRPANaTISGATAILAYFIATGTVIPEVLLLAAAALLI---------TGAGNTINDACDAAIDAINRPDRPIPSGEL 77
Cdd:NF035940   3 LQLMRPAN-IVTAWADILAGFAISGFLTLTWSSAPNDISLIwlllatiglYGGGVVFNDVFDAELDAVERPERPIPSGRV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 973165467  78 SVKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGNI 131
Cdd:NF035940  82 SKQAALLLGSLLLLIGILAAFQVSLLSGVIALAIALAALLYDRFGKHHAIFGPL 135
PRK12392 PRK12392
bacteriochlorophyll c synthase; Provisional
 48-236 9.14e-14

bacteriochlorophyll c synthase; Provisional


Pssm-ID: 171463  Cd Length: 331  Bit Score: 70.11  E-value: 9.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  48 TGAGNTINDACDAAIDAINRPDRPIPSGELSVKTAYLYAALLFILGLSAAFFtnpLCLAIA------IINSILL-LLYAR 120
Cdd:PRK12392  63 TGFSQSVNDYFDLELDRVNEPTRPIPSGRLSEKEALWNSIIVLLLAIGLGVW---LGLHIGgergmvIISSILAgLFVAY 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 121 I-------LKGTVLFGNIAVAYLSGSI-FLFGGALAGvDGLIITVPLAGITLFGTLAREIVKDAEDIDGDAAGGATTLPM 192
Cdd:PRK12392 140 IysapplkLKKNILTSAPAVGFSYGFItFLSANALFS-DIRPEVVWLAGLNFFMAIALIIMNDFKSVEGDKEGGLKSLTV 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 973165467 193 AIGISRSGTIAFgsAIIAVIvsFIPFLW----WGLPYLVGIVILDSAI 236
Cdd:PRK12392 219 MIGAKNTFLVSF--IIIDLV--FAVFAWlawsWGFTVLMYFILVGLVL 262
ubiA PRK12872
prenyltransferase; Reviewed
 8-216 5.75e-12

prenyltransferase; Reviewed


Pssm-ID: 237241  Cd Length: 285  Bit Score: 64.58  E-value: 5.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467   8 RIIRPANATISGATAILAYFIATGTVIPEVLLLAAAALLITGAGNTINDACDAAIDAINRPDRPIPSG----ELSVKTAY 83
Cdd:PRK12872   9 KLFRYGNLLIAALGQSLVYMASLLLGLPISWLLLLITFLIAAAVYIINYLTDLEEDIINKPERVVFSEtkayGLFLLLNV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  84 LYAALLFILglsAAFFTNPLCLAIAIINSILLLLYA----RILKGTVLFGNIAVAYLSGSIFLFGGALAGvdGLIITVPL 159
Cdd:PRK12872  89 LGLYLGAYL---LAVIGGPKFALIFIIPLILGILYSvffkRRLKRIPLFKNLVVSLLWALSPLILGVYYY--QLTIFSLL 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 160 AGITLFGTL---AREIVKDAEDIDGDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFI 216
Cdd:PRK12872 164 LLYAVFIFLksfIREIVFDIKDIEGDRKSGLKTLPIVLGKERTLKFLLILNLLFLILLIL 223
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 49-118 1.49e-11

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 63.25  E-value: 1.49e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 973165467  49 GAGNTINDACDAAIDAINR--PDRPIPSGELSVKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLY 118
Cdd:cd13959   47 SAGCTINDIADRDIDAKVPrtKNRPLASGAISVKEALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIY 118
PLN00012 PLN00012
chlorophyll synthetase; Provisional
 47-206 2.62e-11

chlorophyll synthetase; Provisional


Pssm-ID: 215028  Cd Length: 375  Bit Score: 63.34  E-value: 2.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  47 ITGAGNTINDACDAAIDAINRPDRPIPSGELS---VKTAyLYAALLFILGLSA-----AFFTNPLCLAIAIINSILLLLY 118
Cdd:PLN00012 135 LTGYTQTINDWYDREIDAINEPYRPIPSGAISeneVITQ-IWVLLLGGLGLAYtldvwAGHDFPIVFYLALGGSLLSYIY 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 119 AR---ILKGTVLFGNIAV--AYLS----GSIFLFGGALAGVDGLIITVPLAGitlfgtLAREIVKDAEDIDGDAAGGATT 189
Cdd:PLN00012 214 SApplKLKQNGWIGNYALgaSYISlpwwAGQALFGTLTPDVVVLTLLYSIAG------LGIAIVNDFKSIEGDRALGLQS 287

                        170
                 ....*....|....*..
gi 973165467 190 LPMAIGISRSGTIAFGS 206
Cdd:PLN00012 288 LPVAFGVETAKWICVGS 304
PT_UbiA_3 cd13965
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 63-275 2.19e-10

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260128  Cd Length: 273  Bit Score: 59.97  E-value: 2.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  63 DAINRPDRPIPSGELSVKTAYLYAALLFILGLSAAFFTNPLCLAIAIInsILLLLY-----ARILKGTVLFGNIAV-AYL 136
Cdd:cd13965   64 DRINKPWRPIPSGRITPRQARRLRWLLVPLCLALSAYLGVLEESLLLI--VLTWLYnelglADHWLTRNLLNALGYaAFL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 137 SGSIFLFGGALAGVDGLIITVPLAGITLFGTLAReiVKDAEDIDGDAAGGATTLPMAIGisrSGTIAFGSAIIAVIVSFI 216
Cdd:cd13965  142 AGATRIAGGGPHPLDPTAWAWILLSAAIILTTIH--AQDFRDVEGDRARGRRTLPLVFG---DAAARWLIAAGVVAWSVV 216

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 973165467 217 PFLWWGLPYLVGIVildSAILrSVWPATRCTTPACIRNLKITTQLK--YMMYIALLIFLVA 275
Cdd:cd13965  217 LPYFWGLPPLLAAL---LVAL-GAVVAVRFLLLRSVEADRVTFKLYnlWLSVLYLLPLYSR 273
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 21-241 6.28e-09

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 55.52  E-value: 6.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  21 TAILAYFIATGTVIP--EVLLLAAAALLITGAGNTINDACDAAIDAI-NRP-DRPIPSGELSVKTAYLYAALLFILGLS- 95
Cdd:cd13957   15 TALAGYLLAPGGVPDllLLLLTLLGTALVSASANALNQYIERDIDAKmKRTrNRPLPSGRISPKHALIFGLVLGILGLAl 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  96 AAFFTNPLCLAIAIINSIL-LLLYARILK-GTVLfgNIAVAYLSGSIFLFGGALAgVDGliiTVPLAGITLFGTL----- 168
Cdd:cd13957   95 LALFVNPLTALLGLLGIFLyVFVYTPLKKrTTPL--NTVIGGIAGAIPPLIGWAA-ATG---SLDLGAWLLFLILflwqp 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 973165467 169 ----AREIVKDAEdidgDAAGGATTLPMAIGISRSGTIAFGSAIIAVIVSFIPFLW--WGLPYLVGIVILDSAILRSVW 241
Cdd:cd13957  169 phfwALAILYRDD----YARAGIPMLPVVKGERRTKRQILLYTLLLVPLSLLLYLLglTGWIYLVVALLLGLYFLYLAI 243
PRK12324 PRK12324
decaprenyl-phosphate phosphoribosyltransferase;
54-168 6.52e-08

decaprenyl-phosphate phosphoribosyltransferase;


Pssm-ID: 237058  Cd Length: 295  Bit Score: 52.56  E-value: 6.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  54 INDACDAAIDAiNRPD---RPIPSGELSVKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVLFGN 130
Cdd:PRK12324  65 VNDIRDVEADR-LHPTkrnRPIASGVVSVSLAYILAVVLLVASLALAYLLSPKLALVLLVYLVLNLAYSFKLKHQPVLDV 143

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 973165467 131 IAVAylSGsiFLFgGALAGvdGLIITVPLAG----ITLFGTL 168
Cdd:PRK12324 144 FCIA--SG--FVL-RAIAG--GVAIGVPLSPwlllCTALLSL 178
ubiA PRK12886
prenyltransferase; Reviewed
 55-231 1.07e-06

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 48.92  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  55 NDACDAAIDAIN--RPDRPIPSGELSVKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGT-----VL 127
Cdd:PRK12886  62 NRLIDAEIDARNprTAGRAIPAGLISKGSAILFIVLSSLLMLFAAWFLNPLCLYLSPPALFFLLLYSYCKRFTalahvVL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 128 FGNIAVAYLsgsiflfgGALAGVDGLIITVP--LAGITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIGI--SRSGTIA 203
Cdd:PRK12886 142 GFCLALAPL--------GAWIAIRGTIELPAilLGLAVLFWVAGFDILYALQDLEFDRKEGLHSIPAKLGVngSLWIARV 213

                        170       180
                 ....*....|....*....|....*...
gi 973165467 204 FGSAIIAVIVSFIPFLWWGLPYLVGIVI 231
Cdd:PRK12886 214 FHLLMIGFLFALGISAGLGPWFLAGLAV 241
PT_UbiA_2 cd13963
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 70-127 3.62e-06

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260126  Cd Length: 278  Bit Score: 47.47  E-value: 3.62e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 973165467  70 RPIPSGELSVKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYARILKGTVL 127
Cdd:cd13963   70 RPIASGRLSIPAALALAVVLLLAGLALALLLSPAFLLVLLAYLVLNLAYSLKLKRIPL 127
PT_UbiA_UBIAD1 cd13962
1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the ...
 50-232 8.73e-06

1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Human UBIAD1 is an enzyme involved in the synthesis of MK-4. Menaquinones (MKs, also called bacterial forms) are one of the two forms of natural vitamin K, the other being the plant form, phylloquinone (PK). All forms of vitamin K have a 2-methyl-1,4-naphthoquinone (menadione; K3) ring structure in common. At the 3-position of the ring, PK has a phytyl side chain while MKs have several repeating prenyl units. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260125  Cd Length: 283  Bit Score: 46.35  E-value: 8.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  50 AGNTINDACDA--AIDAINR--PDRPIPSGELSVKTAYLYAALLFIL----GLSAAFFTNPLCLAIAIINSILLLLYA-- 119
Cdd:cd13962   48 GVNLANDYFDYkkGTDTEPRsgPSRVLVSGLLSPRQVLRAALVLLLLaallGLYLVALGGWLLLLLGLLGILAGYFYTgg 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 120 RILKGTVLFGNIAVAYLSGSIFLFGGALAGVDGLIITVPLAGITL-FGTLAREIVKDAEDIDGDAAGGATTLPMAIGISR 198
Cdd:cd13962  128 PFPLSYRGLGELFVFLFFGLLAVLGTYYVQTGSLSWEVLLAALPLgLLIAAILLANNIRDIEADRAAGKRTLAVRLGRKR 207

                        170       180       190
                 ....*....|....*....|....*....|....
gi 973165467 199 SGTIAFGSAIIAVIVSFIPFLWWGLPYLVGIVIL 232
Cdd:cd13962  208 ARRLYAALLLLAYLLLLLLVLLGLLPLWSLLALL 241
PT_UbiA_HPT1 cd13960
Tocopherol phytyltransferase; Tocopherol polyprenyltransferase (TPT1), also known as ...
 54-228 1.48e-05

Tocopherol phytyltransferase; Tocopherol polyprenyltransferase (TPT1), also known as homogentisate phytyltransferase 1 (HPT1), tocopherol phytyltransferase, or VTE2, catalyzes the first step in the biosynthesis of the tocopherol forms of vitamin E, which involves the prenylation of homogentisate using phytyl diphosphate (PDP) as the prenyl donor. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260123  Cd Length: 289  Bit Score: 45.63  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  54 INDACDAAIDAINRPDRPIPSGELSVKTAYLYAALLFILGLSAAFFTNP--------LCLAIAIINSI--LLLLYARILK 123
Cdd:cd13960   57 LNQIYDVEIDKINKPYLPLASGELSVRTAWAIVASCGILGLALGALLGSpllltlllLSLLLGTAYSVppPRLKRFPLLA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 124 GTVLFGNIAVAYlsgSIFLFGGALAGVDGLI-ITVPLAGITLFGTL---AREIVKDAEDIDGDAAGGATTLPMAIG---I 196
Cdd:cd13960  137 ALCILTVRGFLV---NLGFYLHFQAALGLPFaWPPSLWFLTAFMTVfaiVIALFKDIPDVEGDRKFGIRTFSVRLGvkrV 213

                        170       180       190
                 ....*....|....*....|....*....|...
gi 973165467 197 SRSGTIAFGSA-IIAVIVSFIPFLWWGLPYLVG 228
Cdd:cd13960  214 FWLCVGLLLMNyAGAILVGLTSPALFSKIFMVV 246
ubiA PRK12888
4-hydroxybenzoate octaprenyltransferase;
55-118 1.04e-04

4-hydroxybenzoate octaprenyltransferase;


Pssm-ID: 183814  Cd Length: 284  Bit Score: 42.79  E-value: 1.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 973165467  55 NDACDAAIDAIN--RPDRPIPSGELSVKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLY 118
Cdd:PRK12888  59 NRIIDREIDARNprTAGRELVTGAVSVRTAWTGALVALAVFLGAAALLNPLCLALAPLAVAPLVVY 124
ubiA PRK12887
tocopherol phytyltransferase; Reviewed
 54-217 1.20e-03

tocopherol phytyltransferase; Reviewed


Pssm-ID: 183813  Cd Length: 308  Bit Score: 39.57  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  54 INDACDAAIDAINRPDRPIPSGELSVKTAYLYAALLFILGLSAAFFTNPLCLAIAIINSILLLLYA----RiLKGTVLFG 129
Cdd:PRK12887  72 LNQLTDIEIDRINKPHLPLAAGEFSRRQGQRIVIITGILALILAALLGPWLLITVGISLLIGTAYSlppiR-LKRFPLLA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 130 NIAVAYLSGSI-----FLFGGALAGVDGLIIT--VPLAGITLFGTLAREIVKDAEDIDGDAAGGATTLPMAIG------I 196
Cdd:PRK12887 151 ALCIFTVRGVIvnlglFLHFQWLLGGSVLIPPtvWLLTLFVLVFTFAIAIFKDIPDMEGDRQYQITTFTLRLGkqavfkL 230

                        170       180
                 ....*....|....*....|.
gi 973165467 197 SRSGTIAFGSAIIAVIVSFIP 217
Cdd:PRK12887 231 SCWVLTACYLGMIAVGLLSLP 251
MenA COG1575
1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1, ...
 52-272 3.65e-03

1,4-dihydroxy-2-naphthoate polyprenyltransferase [Coenzyme transport and metabolism]; 1,4-dihydroxy-2-naphthoate polyprenyltransferase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 441183  Cd Length: 290  Bit Score: 38.20  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467  52 NTINDACDA--AIDAINR--PDRPIPSGELSVKTAYLYAALLFIL----GLSAAFFTNPLCLAIAIINSILLLLYA---R 120
Cdd:COG1575   52 NLANDYFDYkkGTDTEERvgPSRVIVSGLLSPKQVLRAALLLLALalllGLYLVLLSGWPLLLLGLLGILAAIFYTggpF 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 121 ILKGT--------VLFGNIAVAylsGSIFLFGGALAgVDGLIITVPLAGITLFGTLAREIVkdaeDIDGDAAGGATTLPM 192
Cdd:COG1575  132 PLGYRglgelfvfLFFGLVAVL---GTYYVQTGTLS-WAALLASLPVGLLSAAVLLANNLR----DIETDRAAGKRTLAV 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973165467 193 AIGISRS-------GTIAFGSAIIAVIVSFIPflWWGLPYLVGIVILdsaiLRSVWPATRCTTPACIRNLKITTQLKYMM 265
Cdd:COG1575  204 RLGRKRArrlyaalLLLAYLLILLLVLLGLLP--PWALLALLSLPLA----LKLVRRVLRGAKPEALIPALKNTALLNLL 277


                 ....*..
gi 973165467 266 YIALLIF 272
Cdd:COG1575  278 FGLLLAL 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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