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Conserved domains on  [gi|972942283|gb|ALW85103|]
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hypothetical protein AUC43_08370 [Hymenobacter sedentarius]

Protein Classification

7TM-DISM domain-containing protein; ATP-binding protein; ATP-binding protein; histidine kinase; sensor histidine kinase; sensor histidine kinase; GAF domain-containing sensor histidine kinase; GAF domain-containing sensor histidine kinase; sensor histidine kinase; HAMP domain-containing sensor histidine kinase; sensor histidine kinase; HAMP domain-containing sensor histidine kinase; sensor histidine kinase; sensor histidine kinase; PAS domain-containing sensor histidine kinase; PAS domain-containing sensor histidine kinase; sensor histidine kinase; sensor histidine kinase; histidine kinase; sensor histidine kinase; histidine kinase; sensor histidine kinase; sensor histidine kinase; sensor histidine kinase; sensor histidine kinase( domain architecture ID 12082012)

ATPase similar to histidine kinase domains; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase having a MASE1 sensory domain, similar to Escherichia coli UhpB which functions in sugar-phosphate transport; two-component sensor histidine kinase similar to Actinoplanes garbadinensis GarK which may function in the biosynthesis of the type B lantibiotic actagardine, may include histidine kinases with other functions; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component system signal-transducing histidine kinase; two-component sensor histidine kinase having a MASE1 sensory domain, similar to Escherichia coli UhpB which functions in sugar-phosphate transport; HAMP domain-containing sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; HAMP domain-containing sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase with HAMP signaling domain, functions as a protein kinase that phosphorylates a target protein in response to various signals; PAS domain-containing sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; PAS domain-containing sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; two-component sensor histidine kinase functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; sensor histidine kinase functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase with a sensor protein DegS-like domain functions as a protein kinase that phosphorylates a target protein in response to a signal; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase similar to Staphylococcus aureus VraS and Bacillus subtilis DesK; two-component sensor histidine kinase similar to sensor protein DegS, which plays a role in the transition growth phase together with the transcriptional regulator DegU; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; two-component sensor histidine kinase functions as a protein kinase that phosphorylates a target protein in response to various signals

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
396-644 3.53e-53

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


:

Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 182.90  E-value: 3.53e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 396 TLAWGLFVELLVLSALLTGRFRHTLRQNARLRIQELQQRNEvgRRLIAAQDAEREQLARELHDAMGPNLAALHMawQSEA 475
Cdd:COG4585    3 ALALLGALALLVGALLGLLLALVLLRARRAERAAELERELA--ARAEEAREEERRRIARELHDGVGQSLSAIKL--QLEA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 476 VREALAAAP-KARSIGQLTEEILGQLYEQVRQLSHALLPAEPGTNRLTRSVASLCEALNLNGTPRVITHFDAGIDQLPQA 554
Cdd:COG4585   79 ARRLLDADPeAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 555 VQSAAYRIVAELVNNAVRHAQAQQVEVQLRLHPEVLELCVEDDGRGFGrGEDAPITGIGLRGVRTRTAYLGGTVNIES-P 633
Cdd:COG4585  159 VELALYRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFD-PEAAPGGGLGLRGMRERAEALGGTLTIGSaP 237

                        250
                 ....*....|.
gi 972942283 634 GSGTRVVVRLP 644
Cdd:COG4585  238 GGGTRVRATLP 248
7TMR-DISM_7TM pfam07695
7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...
 205-415 3.08e-12

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).


:

Pssm-ID: 429600 [Multi-domain]  Cd Length: 207  Bit Score: 66.14  E-value: 3.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  205 LLGFYLGS----ALFNLVLFAFLRDRIHLWYGAYVVCVTLFLMMEDGLDAMLLPAGLYRLIWSVGQYNFIVLAGAAGIRI 280
Cdd:pfam07695   4 LLGLFYGIllalALYNLFLFFSLRDRSYLYYVLYLLSFLLYQLSLNGLGFQYLWPNAPPWLNNKLLYLSLLLLLPFFALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  281 -MQLFLRLRSGWRGLYRAGNWLAGSAVafvavyavlfpwavkhnLGLVEVLNGARELLVLLVFGYGWVTLLTVLIGRRRR 359
Cdd:pfam07695  84 fARSFLELKKYLPRLLRLLLGLALLLA-----------------LLLLLLPLFPYTLSLPLAQLLALLFILFLLLLGIIA 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 972942283  360 RLAAYYALTYF-----FFFTGYAVFWLNHLGLTSYNPVYPNTLAWGLFVELLVLSALLTGR 415
Cdd:pfam07695 147 WRKGYKPARYFllawlLLLIGALIDILSLLGLLPSNFFTNYLLQIGSALEVLLLSLALADR 207
7TMR-DISMED2 pfam07696
7TMR-DISM extracellular 2; This entry represents one of two distinct types of extracellular ...
 60-176 6.65e-12

7TMR-DISM extracellular 2; This entry represents one of two distinct types of extracellular domain found in the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) bacterial transmembrane proteins. It is possible that this domain adopts a jelly roll fold and acts as a receptor for carbohydrates and their derivatives. It can also recognize Ca(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 429601  Cd Length: 127  Bit Score: 63.13  E-value: 6.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283   60 SPEQAEAqwRAGKFRPGPwHKTLNLGIMHRRVWMRLPVRNTEPQRLRFLWSIFN-FTDSAALYCRRQGETTFT-RLGAAs 137
Cdd:pfam07696  12 TIEDVLS--ADGRFRPPE-KGVPNFGYSSSAYWLRFTLENPTDAPKDWLLELAYpLLDEIDLYLPDGGGGYREqRLGDR- 87

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 972942283  138 swVPATERLFPARSLSFPFTLNPGEAAVLYLRadVHTGG 176
Cdd:pfam07696  88 --LPFSQRPVAHRNFVFPLPLPPGETVTLYLR--VKSSG 122
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
396-644 3.53e-53

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 182.90  E-value: 3.53e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 396 TLAWGLFVELLVLSALLTGRFRHTLRQNARLRIQELQQRNEvgRRLIAAQDAEREQLARELHDAMGPNLAALHMawQSEA 475
Cdd:COG4585    3 ALALLGALALLVGALLGLLLALVLLRARRAERAAELERELA--ARAEEAREEERRRIARELHDGVGQSLSAIKL--QLEA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 476 VREALAAAP-KARSIGQLTEEILGQLYEQVRQLSHALLPAEPGTNRLTRSVASLCEALNLNGTPRVITHFDAGIDQLPQA 554
Cdd:COG4585   79 ARRLLDADPeAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 555 VQSAAYRIVAELVNNAVRHAQAQQVEVQLRLHPEVLELCVEDDGRGFGrGEDAPITGIGLRGVRTRTAYLGGTVNIES-P 633
Cdd:COG4585  159 VELALYRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFD-PEAAPGGGLGLRGMRERAEALGGTLTIGSaP 237

                        250
                 ....*....|.
gi 972942283 634 GSGTRVVVRLP 644
Cdd:COG4585  238 GGGTRVRATLP 248
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
423-644 2.69e-24

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 106.99  E-value: 2.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 423 NARLRIqELQQRNEVGRRLIAAQDAEREQLARELHDAMGPNLAALHMawQSEAVREALAAAPKARSIGQLTEEILGQLYE 502
Cdd:PRK11644 277 NQSLQK-ELARNRHLAERLLETEESVRRDVARELHDEIGQTITAIRT--QAGIIKRLAADNASVKQSAQLIEQLSLGVYD 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 503 QVRQLSHALLPAEPGTNRLTRSVASLCEALNLNGTpRVITHFDAGIDQ--LPQAVQSAAYRIVAELVNNAVRHAQAQQVE 580
Cdd:PRK11644 354 TVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEDR-GIVSHLDWRIDEsaLSETQRVTLFRVCQEGLNNIVKHADASAVT 432

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 972942283 581 VQLRLHPEVLELCVEDDGRGFGRGEdaPITGIGLRGVRTRTAYLGGTVNIESPgSGTRVVVRLP 644
Cdd:PRK11644 433 LQGWQQDERLMLVIEDDGSGLPPGS--GQQGFGLRGMRERVTALGGTLTISCT-HGTRLSVSLP 493
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 559-644 3.88e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 96.47  E-value: 3.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 559 AYRIVAELVNNAVRHAQAQQVEVQLRLHPEVLELCVEDDGRGFGRGEDAPITGIGLRGVRTRTAYLGGTVNIES-PGSGT 637
Cdd:cd16917    1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGGGFGLLGMRERAELLGGTLTIGSrPGGGT 80


                 ....*..
gi 972942283 638 RVVVRLP 644
Cdd:cd16917   81 RVTARLP 87
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 560-645 5.04e-17

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 76.92  E-value: 5.04e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283   560 YRIVAELVNNAVRHAQAQ-QVEVQLRLHPEVLELCVEDDGRG------------FGRGEDA----PITGIGLRGVRTRTA 622
Cdd:smart00387   7 RQVLSNLLDNAIKYTPEGgRITVTLERDGDHVEITVEDNGPGippedlekifepFFRTDKRsrkiGGTGLGLSIVKKLVE 86

                           90       100
                   ....*....|....*....|....
gi 972942283   623 YLGGTVNIES-PGSGTRVVVRLPY 645
Cdd:smart00387  87 LHGGEISVESePGGGTTFTITLPL 110
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 554-644 1.54e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 72.79  E-value: 1.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  554 AVQSAAYRIVAELVNNAVRHA-QAQQVEVQLRlHPEVLELCVEDDGRG---------FGRGEDAPI-----TGIGLRGVR 618
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAaKAGEITVTLS-EGGELTLTVEDNGIGippedlpriFEPFSTADKrggggTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*..
gi 972942283  619 TRTAYLGGTVNIES-PGSGTRVVVRLP 644
Cdd:pfam02518  80 KLVELLGGTITVESePGGGTTVTLTLP 106
7TMR-DISM_7TM pfam07695
7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...
 205-415 3.08e-12

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).


Pssm-ID: 429600 [Multi-domain]  Cd Length: 207  Bit Score: 66.14  E-value: 3.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  205 LLGFYLGS----ALFNLVLFAFLRDRIHLWYGAYVVCVTLFLMMEDGLDAMLLPAGLYRLIWSVGQYNFIVLAGAAGIRI 280
Cdd:pfam07695   4 LLGLFYGIllalALYNLFLFFSLRDRSYLYYVLYLLSFLLYQLSLNGLGFQYLWPNAPPWLNNKLLYLSLLLLLPFFALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  281 -MQLFLRLRSGWRGLYRAGNWLAGSAVafvavyavlfpwavkhnLGLVEVLNGARELLVLLVFGYGWVTLLTVLIGRRRR 359
Cdd:pfam07695  84 fARSFLELKKYLPRLLRLLLGLALLLA-----------------LLLLLLPLFPYTLSLPLAQLLALLFILFLLLLGIIA 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 972942283  360 RLAAYYALTYF-----FFFTGYAVFWLNHLGLTSYNPVYPNTLAWGLFVELLVLSALLTGR 415
Cdd:pfam07695 147 WRKGYKPARYFllawlLLLIGALIDILSLLGLLPSNFFTNYLLQIGSALEVLLLSLALADR 207
7TMR-DISMED2 pfam07696
7TMR-DISM extracellular 2; This entry represents one of two distinct types of extracellular ...
 60-176 6.65e-12

7TMR-DISM extracellular 2; This entry represents one of two distinct types of extracellular domain found in the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) bacterial transmembrane proteins. It is possible that this domain adopts a jelly roll fold and acts as a receptor for carbohydrates and their derivatives. It can also recognize Ca(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429601  Cd Length: 127  Bit Score: 63.13  E-value: 6.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283   60 SPEQAEAqwRAGKFRPGPwHKTLNLGIMHRRVWMRLPVRNTEPQRLRFLWSIFN-FTDSAALYCRRQGETTFT-RLGAAs 137
Cdd:pfam07696  12 TIEDVLS--ADGRFRPPE-KGVPNFGYSSSAYWLRFTLENPTDAPKDWLLELAYpLLDEIDLYLPDGGGGYREqRLGDR- 87

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 972942283  138 swVPATERLFPARSLSFPFTLNPGEAAVLYLRadVHTGG 176
Cdd:pfam07696  88 --LPFSQRPVAHRNFVFPLPLPPGETVTLYLR--VKSSG 122
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
396-644 3.53e-53

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 182.90  E-value: 3.53e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 396 TLAWGLFVELLVLSALLTGRFRHTLRQNARLRIQELQQRNEvgRRLIAAQDAEREQLARELHDAMGPNLAALHMawQSEA 475
Cdd:COG4585    3 ALALLGALALLVGALLGLLLALVLLRARRAERAAELERELA--ARAEEAREEERRRIARELHDGVGQSLSAIKL--QLEA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 476 VREALAAAP-KARSIGQLTEEILGQLYEQVRQLSHALLPAEPGTNRLTRSVASLCEALNLNGTPRVITHFDAGIDQLPQA 554
Cdd:COG4585   79 ARRLLDADPeAAREELEEIRELAREALAELRRLVRGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 555 VQSAAYRIVAELVNNAVRHAQAQQVEVQLRLHPEVLELCVEDDGRGFGrGEDAPITGIGLRGVRTRTAYLGGTVNIES-P 633
Cdd:COG4585  159 VELALYRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFD-PEAAPGGGLGLRGMRERAEALGGTLTIGSaP 237

                        250
                 ....*....|.
gi 972942283 634 GSGTRVVVRLP 644
Cdd:COG4585  238 GGGTRVRATLP 248
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 413-644 1.42e-35

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 140.53  E-value: 1.42e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 413 TGRFRHtlrQNARLRiQELQQRNEVGRRLIAAQDAEREQLARELHDAMGPNLAALHMawQSEAVREaLAAAPKARSIGQL 492
Cdd:COG3851  261 IQRQRQ---LNQQLE-QELRENRALARQLVSAEESERREIARELHDEIGQNITAIRT--QASILKR-LAPQPEIEQSAQS 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 493 TEEILGQLYEQVRQLSHALLPAEPGTNRLTRSVASLCEALNLNgTPRVITHFDAGIDQ--LPQAVQSAAYRIVAELVNNA 570
Cdd:COG3851  334 IESLALRIYDTTRRLLDRLRPAVLDELGLEEALRELPRELAFE-EPGISCQLDLRGDPslLDDTLQLTLYRLVQEALTNI 412

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 972942283 571 VRHAQAQQVEVQLRLHPEVLELCVEDDGRGFgrGEDAPITGIGLRGVRTRTAYLGGTVNIESPGSGTRVVVRLP 644
Cdd:COG3851  413 LKHAEASQIRISLSQDKRLLSLEIRDDGIGL--PPELRAKGFGLRGMRERVRALGGDFRLSSAPKGTRLSVLLP 484
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
423-644 2.69e-24

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 106.99  E-value: 2.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 423 NARLRIqELQQRNEVGRRLIAAQDAEREQLARELHDAMGPNLAALHMawQSEAVREALAAAPKARSIGQLTEEILGQLYE 502
Cdd:PRK11644 277 NQSLQK-ELARNRHLAERLLETEESVRRDVARELHDEIGQTITAIRT--QAGIIKRLAADNASVKQSAQLIEQLSLGVYD 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 503 QVRQLSHALLPAEPGTNRLTRSVASLCEALNLNGTpRVITHFDAGIDQ--LPQAVQSAAYRIVAELVNNAVRHAQAQQVE 580
Cdd:PRK11644 354 TVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEDR-GIVSHLDWRIDEsaLSETQRVTLFRVCQEGLNNIVKHADASAVT 432

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 972942283 581 VQLRLHPEVLELCVEDDGRGFGRGEdaPITGIGLRGVRTRTAYLGGTVNIESPgSGTRVVVRLP 644
Cdd:PRK11644 433 LQGWQQDERLMLVIEDDGSGLPPGS--GQQGFGLRGMRERVTALGGTLTISCT-HGTRLSVSLP 493
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 559-644 3.88e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 96.47  E-value: 3.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 559 AYRIVAELVNNAVRHAQAQQVEVQLRLHPEVLELCVEDDGRGFGRGEDAPITGIGLRGVRTRTAYLGGTVNIES-PGSGT 637
Cdd:cd16917    1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPAPPGGGGFGLLGMRERAELLGGTLTIGSrPGGGT 80


                 ....*..
gi 972942283 638 RVVVRLP 644
Cdd:cd16917   81 RVTARLP 87
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 560-645 5.04e-17

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 76.92  E-value: 5.04e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283   560 YRIVAELVNNAVRHAQAQ-QVEVQLRLHPEVLELCVEDDGRG------------FGRGEDA----PITGIGLRGVRTRTA 622
Cdd:smart00387   7 RQVLSNLLDNAIKYTPEGgRITVTLERDGDHVEITVEDNGPGippedlekifepFFRTDKRsrkiGGTGLGLSIVKKLVE 86

                           90       100
                   ....*....|....*....|....
gi 972942283   623 YLGGTVNIES-PGSGTRVVVRLPY 645
Cdd:smart00387  87 LHGGEISVESePGGGTTFTITLPL 110
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 554-644 1.54e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 72.79  E-value: 1.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  554 AVQSAAYRIVAELVNNAVRHA-QAQQVEVQLRlHPEVLELCVEDDGRG---------FGRGEDAPI-----TGIGLRGVR 618
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAaKAGEITVTLS-EGGELTLTVEDNGIGippedlpriFEPFSTADKrggggTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*..
gi 972942283  619 TRTAYLGGTVNIES-PGSGTRVVVRLP 644
Cdd:pfam02518  80 KLVELLGGTITVESePGGGTTVTLTLP 106
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
448-644 4.85e-13

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 72.19  E-value: 4.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 448 EREQLARELHDAMGPNLAALHMawQSEAVREALAAA-PKARSIGQLTEEILGQLYEQVRQLshalLpaepGTNRLTRSVA 526
Cdd:PRK10935 363 ERATIARELHDSLAQVLSYLKI--QLTLLKRSLDEDnAKAQSIIAEFDQALSDAYRQLREL----L----TTFRLTIQEA 432

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 527 SLCEAL---------------NLNGTPRViTHFDAGidQLPQAVQsaayrIVAELVNNAVRHAQAQQVEVQLRLHPE-VL 590
Cdd:PRK10935 433 NLGSALeemldqlrnqtdakiTLDCRLPS-QALDAQ--QQVHLLQ-----IIREATLNAIKHANASEIAVSCVTNPDgEH 504

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 972942283 591 ELCVEDDGRGFGRGEDaPITGIGLRGVRTRTAYLGGTVNIES-PGSGTRVVVRLP 644
Cdd:PRK10935 505 TVSIRDDGIGIGELKE-PEGHYGLNIMQERAERLGGTLTISQpPGGGTTVSLTFP 558
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
339-644 6.71e-13

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 70.32  E-value: 6.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 339 LLVFGYGWVTLLTVLIGRRRRRLAAYYALTYFFFFTGYAVFWLNHLGLTSYNPVYPNTLAWGLFVELLVLSALLTGRFRH 418
Cdd:COG0642    1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 419 TLRQNARLRIQELQQRNEVGRRLIAAQDAEREQLARELHDAMGPnLAALHMAWQ------SEAVREALAAAPK-ARSIGQ 491
Cdd:COG0642   81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTP-LTAIRGYLEllleelDEEQREYLETILRsADRLLR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 492 LTEEILgqlyeQVRQLSHALLPAEPGT---NRLTRSVASLCEALNLNGTPRVITHFDAGIDQLpQAVQSAAYRIVAELVN 568
Cdd:COG0642  160 LINDLL-----DLSRLEAGKLELEPEPvdlAELLEEVVELFRPLAEEKGIELELDLPDDLPTV-RGDPDRLRQVLLNLLS 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 569 NAVRHAQA-QQVEVQLRLHPEVLELCVEDDGRG------------FGRGEDAPI---TGIGLRGVRTRTAYLGGTVNIES 632
Cdd:COG0642  234 NAIKYTPEgGTVTVSVRREGDRVRISVEDTGPGippedlerifepFFRTDPSRRgggTGLGLAIVKRIVELHGGTIEVES 313

                        330
                 ....*....|...
gi 972942283 633 -PGSGTRVVVRLP 644
Cdd:COG0642  314 ePGKGTTFTVTLP 326
7TMR-DISM_7TM pfam07695
7TM diverse intracellular signalling; This entry represents the transmembrane region of the ...
 205-415 3.08e-12

7TM diverse intracellular signalling; This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).


Pssm-ID: 429600 [Multi-domain]  Cd Length: 207  Bit Score: 66.14  E-value: 3.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  205 LLGFYLGS----ALFNLVLFAFLRDRIHLWYGAYVVCVTLFLMMEDGLDAMLLPAGLYRLIWSVGQYNFIVLAGAAGIRI 280
Cdd:pfam07695   4 LLGLFYGIllalALYNLFLFFSLRDRSYLYYVLYLLSFLLYQLSLNGLGFQYLWPNAPPWLNNKLLYLSLLLLLPFFALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  281 -MQLFLRLRSGWRGLYRAGNWLAGSAVafvavyavlfpwavkhnLGLVEVLNGARELLVLLVFGYGWVTLLTVLIGRRRR 359
Cdd:pfam07695  84 fARSFLELKKYLPRLLRLLLGLALLLA-----------------LLLLLLPLFPYTLSLPLAQLLALLFILFLLLLGIIA 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 972942283  360 RLAAYYALTYF-----FFFTGYAVFWLNHLGLTSYNPVYPNTLAWGLFVELLVLSALLTGR 415
Cdd:pfam07695 147 WRKGYKPARYFllawlLLLIGALIDILSLLGLLPSNFFTNYLLQIGSALEVLLLSLALADR 207
7TMR-DISMED2 pfam07696
7TMR-DISM extracellular 2; This entry represents one of two distinct types of extracellular ...
 60-176 6.65e-12

7TMR-DISM extracellular 2; This entry represents one of two distinct types of extracellular domain found in the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) bacterial transmembrane proteins. It is possible that this domain adopts a jelly roll fold and acts as a receptor for carbohydrates and their derivatives. It can also recognize Ca(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429601  Cd Length: 127  Bit Score: 63.13  E-value: 6.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283   60 SPEQAEAqwRAGKFRPGPwHKTLNLGIMHRRVWMRLPVRNTEPQRLRFLWSIFN-FTDSAALYCRRQGETTFT-RLGAAs 137
Cdd:pfam07696  12 TIEDVLS--ADGRFRPPE-KGVPNFGYSSSAYWLRFTLENPTDAPKDWLLELAYpLLDEIDLYLPDGGGGYREqRLGDR- 87

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 972942283  138 swVPATERLFPARSLSFPFTLNPGEAAVLYLRadVHTGG 176
Cdd:pfam07696  88 --LPFSQRPVAHRNFVFPLPLPPGETVTLYLR--VKSSG 122
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
430-644 1.83e-11

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 64.54  E-value: 1.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 430 ELQQRNEVGRRLiaaqDAEREQLAREL-HDAMGPnLAALHMAWQSEAVREALAAAPKARSIGQLTEEI--LGQLYEQVRQ 506
Cdd:COG2205    1 ELEEALEELEEL----ERLKSEFLANVsHELRTP-LTSILGAAELLLDEEDLSPEERRELLEIIRESAerLLRLIEDLLD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 507 LS---HALLPAEPGT---NRLTRSVASLCEALNLNGTPRVITHFDAGIDQLpQAVQSAAYRIVAELVNNAVRHAQAQ-QV 579
Cdd:COG2205   76 LSrleSGKLSLELEPvdlAELLEEAVEELRPLAEEKGIRLELDLPPELPLV-YADPELLEQVLANLLDNAIKYSPPGgTI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 580 EVQLRLHPEVLELCVEDDGRG------------FGRGEDA---PITGIGLRGVRTRTAYLGGTVNIES-PGSGTRVVVRL 643
Cdd:COG2205  155 TISARREGDGVRISVSDNGPGipeeeleriferFYRGDNSrgeGGTGLGLAIVKRIVEAHGGTIWVESePGGGTTFTVTL 234


                 .
gi 972942283 644 P 644
Cdd:COG2205  235 P 235
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 566-644 6.28e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 59.37  E-value: 6.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 566 LVNNAVRHAQAQ-----QVEVQLRLHPEVLELCVEDDGRGF-----GRGEDAPITGIGLRGVRTRTAYLGGT---VNIES 632
Cdd:cd16956    9 IVENAVKHGLSGlldggRVEITARLDGQHLLLEVEDNGGGMdpdtlARILIRSSNGLGLNLVDKRLRQAFGNdygLDIEC 88

                         90
                 ....*....|...
gi 972942283 633 -PGSGTRVVVRLP 644
Cdd:cd16956   89 aPGEGTRITIRLP 101
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 162-644 8.13e-11

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 64.93  E-value: 8.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 162 EAAVLYLRADVHTGGVYLPTYIETAEHFLSWEMHFPFERHWVWLLGFYLGSALFNLVLFAFLRDRIHLWYGAYVVCVTLF 241
Cdd:COG3920   12 ALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 242 LMMEDGLDAMLLPAGLYRLIWSVGQYNFIVLAGAAGIRIMQLFLRLRSGWRGLYRAGNWLAGSAVAFVAVYAVLFPWAVK 321
Cdd:COG3920   92 LLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALR 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 322 HNLGLVEVLNGARELLVLLVFGYGWVTLLTVLIGRRRRRLAAYYALTYFFFFTGYAVFWLNHLGLTSYNPVYPNTLAWGL 401
Cdd:COG3920  172 LAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLG 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 402 FVELLVLSALLTGRFRHTLRQNARLRIQELQQRNevgrRLIAAQDAEREQLARELHDAMGPNLA------ALHMA-WQSE 474
Cdd:COG3920  252 RLLLLLLLLLLLLRALLLLAAGIRLVITERKRAE----EELEASLEEKELLLRELHHRVKNNLQvvssllRLQARrADDP 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 475 AVREALAAApKAR--SIGQLTEeilgQLYEQvRQLSHAllpaepgtnRLTRSVASLCEALNLNGTPRVIThFDAGIDQL- 551
Cdd:COG3920  328 EAREALEES-QNRiqALALVHE----LLYQS-EDWEGV---------DLRDYLRELLEPLRDSYGGRGIR-IELDGPDVe 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 552 --PQAVQSAAyRIVAELVNNAVRHA----QAQQVEVQLRLHPEVLELCVEDDGRGFGRGEDAP-ITGIGLRGVRTRTAYL 624
Cdd:COG3920  392 lpADAAVPLG-LILNELVTNALKHAflsgEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDPPaRKGLGLRLIRALVRQL 470

                        490       500
                 ....*....|....*....|
gi 972942283 625 GGTVNIESPgSGTRVVVRLP 644
Cdd:COG3920  471 GGTLELDRP-EGTRVRITFP 489
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
562-644 1.11e-10

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 59.54  E-value: 1.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 562 IVAELVNNAVRHAQAQQ----VEVQLRLHPEVLELCVEDDGRGF------GRGEDAPITGIGLRGVRTrtayLGGTVNIE 631
Cdd:COG2172   38 AVSEAVTNAVRHAYGGDpdgpVEVELELDPDGLEIEVRDEGPGFdpedlpDPYSTLAEGGRGLFLIRR----LMDEVEYE 113

                         90
                 ....*....|...
gi 972942283 632 SPGSGTRVVVRLP 644
Cdd:COG2172  114 SDPGGTTVRLVKR 126
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 400-645 3.83e-10

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 62.17  E-value: 3.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 400 GLFVELLVLSALLTGRFRHTLRQNARL----RIQELQQRNEVGRRLIAAQDAEREQLAREL--------------HDAMg 461
Cdd:COG3290  123 GRPIDEVLAEVLETGERDEEILLNGRVlvvnRVPIRDDGRVVGAVATFRDRTELERLEEELegvkelaealraqrHDFR- 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 462 pN-LAALHMAWQSEAVREALAAapkarsIGQLTEEILGQLYEQVRQLSHALLPAepgtnrLTRSVASLCEALNlngtPRV 540
Cdd:COG3290  202 -NhLHTISGLLQLGEYDEALEY------IDEISEELQELIDSLLSRIGNPVLAA------LLLGKAARARERG----IDL 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 541 ITHFDAGIDQLPQAVQSAAyRIVAELVNNAVRHAQAQ-----QVEVQLRLHPEVLELCVEDDGRG---------FGRGE- 605
Cdd:COG3290  265 TIDIDSDLPDLPLSDTDLV-TILGNLLDNAIEAVEKLpeeerRVELSIRDDGDELVIEVEDSGPGipeellekiFERGFs 343

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 972942283 606 --DAPITGIGLRGVRTRTAYLGGTVNIES-PGSGTRVVVRLPY 645
Cdd:COG3290  344 tkLGEGRGLGLALVKQIVEKYGGTIEVESeEGEGTVFTVRLPK 386
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 448-515 4.47e-10

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 56.09  E-value: 4.47e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 972942283  448 EREQLARELHDAMGPNLAALHMawQSEAVREALAAAP-KARSIGQLTEEILGQLYEQVRQLSHALLPAE 515
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKL--QLELARRLLDRDPeEAREQLDAIRELAREALQELRRLLGDLRPPA 67
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 324-644 4.59e-09

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 58.66  E-value: 4.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 324 LGLVEVLNGARELLVLLVFGYGWVTLLTVLIGRRRRRLAAYYALTYFFFFTGYAVFWLNHLGLTSYNPVYPNTLAWGLFV 403
Cdd:COG4191    2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 404 ELLVLSALLTGRFRHTLRQNARLRIQELQQRNEVGRRLIAAQdAEREQLARELHD-----AMG------------PnLAA 466
Cdd:COG4191   82 LGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAE-EELRELQEQLVQseklaALGelaagiaheinnP-LAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 467 LHMAwqSEAVREALAAAPKARSIGQLTEEILGQLyEQVRQLSHALL------PAEPGT---NRLTRSVASLCEALNLNGT 537
Cdd:COG4191  160 ILGN--AELLRRRLEDEPDPEELREALERILEGA-ERAAEIVRSLRafsrrdEEEREPvdlNELIDEALELLRPRLKARG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 538 PRVITHFDAGIDQL---PQAVQsaayRIVAELVNNAvRHA----QAQQVEVQLRLHPEVLELCVEDDGRG---------F 601
Cdd:COG4191  237 IEVELDLPPDLPPVlgdPGQLE----QVLLNLLINA-IDAmeegEGGRITISTRREGDYVVISVRDNGPGippevleriF 311

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 972942283 602 ---------GRGedapiTGIGLRGVRTRTAYLGGTVNIES-PGSGTRVVVRLP 644
Cdd:COG4191  312 epffttkpvGKG-----TGLGLSISYGIVEKHGGRIEVESePGGGTTFTITLP 359
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
448-642 5.84e-09

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 58.91  E-value: 5.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 448 EREQLARELHDAMGPNLAALHMawQSEAVREALAAAPKARS--IGQLTEEiLGQLYEQVRQL--SHALLPAEPGtnrLTR 523
Cdd:PRK10600 361 ERATIARELHDSIAQSLSCMKM--QVSCLQMQGDALPESSRelLSQIRNE-LNASWRQLRELltTFRLQLTEPG---LRP 434

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 524 SVASLCEALNLN-GTPrVITHFdagidQLP-QAVQSAA----YRIVAELVNNAVRHAQAQQVEVQLRLHPEVLELCVEDD 597
Cdd:PRK10600 435 ALEASCEEFSARfGFP-VKLDY-----QLPpRLVPSHQaihlLQIAREALSNALKHAQASEVVVTVAQNQNQVKLSVQDN 508

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 972942283 598 GRGFgrGEDAPITG-IGLRGVRTRTAYLGGTVNIES-PGSGTRVVVR 642
Cdd:PRK10600 509 GCGV--PENAERSNhYGLIIMRDRAQSLRGDCRVRRrESGGTEVVVT 553
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
566-645 8.46e-09

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 57.96  E-value: 8.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 566 LVNNAVRHAQAQQ-----VEVQLRLHPEVLELCVEDDGRGFGRGEDAPITGIGLRGVRTRTAYLGG---TVNIES-PGSG 636
Cdd:COG3275  261 LVENAIKHGISSKegggtISISIEVEGDRLVIEVENNGVGIQPKKKKKGSGIGLKNVRERLELLYGdkySLEIEStDGGG 340


                 ....*....
gi 972942283 637 TRVVVRLPY 645
Cdd:COG3275  341 TKVTLKIPL 349
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 562-644 1.64e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 53.58  E-value: 1.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 562 IVAELVNNAVRHAQAQQVEVQLRLHPEV----LELCVEDDGRGFGRGEDAPITG-IGLRGVRTR-TAYLGGTVNIESPGS 635
Cdd:cd16951   43 VVNELLQNALKHAFSDREGGTITIRSVVdgdyLRITVIDDGVGLPQDEDWPNKGsLGLQIVRSLvEGELKAFLEVQSAEN 122


                 ....*....
gi 972942283 636 GTRVVVRLP 644
Cdd:cd16951  123 GTRVNIDIP 131
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
566-645 9.89e-08

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 54.64  E-value: 9.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 566 LVNNAVRHAQAQQ-----VEVQLRLHPEVLELCVEDDGRGFGRGEDAPI----------TGIGLRGVRTRTAYL---GGT 627
Cdd:COG2972  344 LVENAIEHGIEPKegggtIRISIRKEGDRLVITVEDNGVGMPEEKLEKLleelsskgegRGIGLRNVRERLKLYygeEYG 423

                         90
                 ....*....|....*....
gi 972942283 628 VNIES-PGSGTRVVVRLPY 645
Cdd:COG2972  424 LEIESePGEGTTVTIRIPL 442
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 562-643 9.93e-08

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 49.96  E-value: 9.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 562 IVAELVNNAVRHAQA----QQVEVQLRLHPEVLELCVEDDGRGFGR------GEDAPITGIGLRGVRTrtayLGGTVNIE 631
Cdd:cd16936    4 AVSEAVTNAVRHAYRhdgpGPVRLELDLDPDRLRVEVTDSGPGFDPlrpadpDAGLREGGRGLALIRA----LMDEVGYR 79

                         90
                 ....*....|..
gi 972942283 632 SPGSGTRVVVRL 643
Cdd:cd16936   80 RTPGGKTVWLEL 91
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
561-644 6.40e-07

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 52.25  E-value: 6.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 561 RIVAELVNNAVRHAQA-QQVEVQLRLHPEVLELCVEDDGRG------------FGRGEDAPI-----TGIGLRGVRTRTA 622
Cdd:COG5002  284 QVLTNLLDNAIKYTPEgGTITVSLREEDDQVRISVRDTGIGipeedlpriferFYRVDKSRSretggTGLGLAIVKHIVE 363

                         90       100
                 ....*....|....*....|...
gi 972942283 623 YLGGTVNIES-PGSGTRVVVRLP 644
Cdd:COG5002  364 AHGGRIWVESePGKGTTFTITLP 386
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 561-644 7.09e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 45.11  E-value: 7.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 561 RIVAELVNNAVRHAqAQQVEVQLRLHPEVLELCVEDDGRGF-----------------GRGEDAPITGIGLRGVRTRTAY 623
Cdd:cd16939    3 RALDNLLRNALRYA-HRTVRIALLVSGGRLTLIVEDDGPGIpaaarervfepfvrldpSRDRATGGFGLGLAIVHRVALW 81

                         90       100
                 ....*....|....*....|..
gi 972942283 624 LGGTVNI-ESPGSGTRVVVRLP 644
Cdd:cd16939   82 HGGHVECdDSELGGACFRLTWP 103
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 527-643 1.42e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 44.93  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 527 SLCEALN-LNGTPRVITHFDAGIDQLPQAVQSAAYRIVAELVNNAVRHAQaQQVEVQLRLHPEVLELCVEDDGRG----- 600
Cdd:cd16954    5 SLCSALNkVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCL-EFVEVTARQTDGGLHLIVDDDGPGvpesq 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 972942283 601 ----FGRGEDA----PITGIGLRGVRTRTAYLGGTVNIE-SPGSGTRVVVRL 643
Cdd:cd16954   84 rskiFQRGQRLdeqrPGQGLGLAIAKEIVEQYGGELSLSdSPLGGARFEVVF 135
HATPase_c_2 pfam13581
Histidine kinase-like ATPase domain;
563-642 1.77e-05

Histidine kinase-like ATPase domain;


Pssm-ID: 433327 [Multi-domain]  Cd Length: 127  Bit Score: 44.59  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  563 VAELVNNAVRHAQ----AQQVEVQLRLHPEVLELCVEDDGRGFG-----------RGEDAPITGIGLRGVRTrtayLGGT 627
Cdd:pfam13581  36 VGEACTNAVEHAYregpEGPVEVRLTSDGGGLVVTVADSGPPFDpltlpppdleePDEDRKEGGRGLALIRG----LMDD 111

                          90
                  ....*....|....*
gi 972942283  628 VNIESPGSGTRVVVR 642
Cdd:pfam13581 112 VEYTRGGEGNTVRMR 126
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 519-644 2.21e-05

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 47.26  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 519 NRLTRSVASLCEALNLNGTPRVITHFDAGI-------DQLPQAVQsaayrivaELVNNAVRHAQAQ-QVEVQLRLHPEVL 590
Cdd:COG5000  279 NELLREVLALYEPALKEKDIRLELDLDPDLpevladrDQLEQVLI--------NLLKNAIEAIEEGgEIEVSTRREDGRV 350

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 972942283 591 ELCVEDDGRGF----------------GRGedapiTGIGLRGVRTRTAYLGGTVNIES-PGSGTRVVVRLP 644
Cdd:COG5000  351 RIEVSDNGPGIpeevlerifepffttkPKG-----TGLGLAIVKKIVEEHGGTIELESrPGGGTTFTIRLP 416
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 562-644 5.69e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 42.66  E-value: 5.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 562 IVAELVNNAVRHAQAQ-----QVEVQLRLHPEVLELCVEDDGRG---------FGRGEDAPIT---GIGLRGVRTRTAYL 624
Cdd:cd16915    4 IVGNLIDNALDALAATgapnkQVEVFLRDEGDDLVIEVRDTGPGiapelrdkvFERGVSTKGQgerGIGLALVRQSVERL 83

                         90       100
                 ....*....|....*....|.
gi 972942283 625 GGTVNIES-PGSGTRVVVRLP 644
Cdd:cd16915   84 GGSITVESePGGGTTFSIRIP 104
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
377-644 8.53e-05

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 45.22  E-value: 8.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 377 AVFWLN-HLGLTSYNPVYPNTLAWGL-------FVELLVLSALLTGRFRHTLRQNARLRIQELQQRNEVGRRLIA----- 443
Cdd:COG3852   19 AVIVLDaDGRITYVNPAAERLLGLSAeellgrpLAELFPEDSPLRELLERALAEGQPVTEREVTLRRKDGEERPVdvsvs 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 444 --AQDAEREQLARELHDamgpnlaalhmawQSEAVR--EALAAAPKARSIGQLTE----EI---LG------QLYEQ--- 503
Cdd:COG3852   99 plRDAEGEGGVLLVLRD-------------ITERKRleRELRRAEKLAAVGELAAglahEIrnpLTgirgaaQLLERelp 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 504 ---------------------VRQLshaLLPAEPGT--------NRLTRSVASLCEALnLNGTPRVITHFDAGI------ 548
Cdd:COG3852  166 ddelreytqliieeadrlnnlVDRL---LSFSRPRPperepvnlHEVLERVLELLRAE-APKNIRIVRDYDPSLpevlgd 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 549 -DQLPQAVQSaayrivaeLVNNA-----------VRHAQAQQVEVQLRLHPEVLELCVEDDGRG---------F-----G 602
Cdd:COG3852  242 pDQLIQVLLN--------LVRNAaeampeggtitIRTRVERQVTLGGLRPRLYVRIEVIDNGPGipeeildriFepfftT 313

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 972942283 603 RGEDapiTGIGLRgvrtrTAY-----LGGTVNIES-PGSGTRVVVRLP 644
Cdd:COG3852  314 KEKG---TGLGLA-----IVQkiveqHGGTIEVESePGKGTTFRIYLP 353
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 562-644 1.96e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 41.12  E-value: 1.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 562 IVAELVNNAVRH-AQAQQVEVQLRLHPEVLELCVEDDGRG---------FGRG-------EDAPITGIGLRGVRTRTAYL 624
Cdd:cd16948    9 IIGQIVSNALKYsKQGGKIEIYSETNEQGVVLSIKDFGIGipeedlprvFDKGftgengrNFQESTGMGLYLVKKLCDKL 88

                         90       100
                 ....*....|....*....|.
gi 972942283 625 GGTVNIES-PGSGTRVVVRLP 644
Cdd:cd16948   89 GHKIDVESeVGEGTTFTITFP 109
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 566-644 2.10e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 40.94  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 566 LVNNAVRHAQAQQVEVQLRL-----HPEVLELCVEDDGRGFGRGE-----------DAPI------TGIGLRGVRTRTAY 623
Cdd:cd16922    8 LLGNAIKFTEEGEVTLRVSLeeeeeDGVQLRFSVEDTGIGIPEEQqarlfepfsqaDSSTtrkyggTGLGLAISKKLVEL 87

                         90       100
                 ....*....|....*....|..
gi 972942283 624 LGGTVNIES-PGSGTRVVVRLP 644
Cdd:cd16922   88 MGGDISVESePGQGSTFTFTLP 109
PRK07353 PRK07353
F0F1 ATP synthase subunit B'; Validated
 429-512 5.48e-04

F0F1 ATP synthase subunit B'; Validated


Pssm-ID: 235999 [Multi-domain]  Cd Length: 140  Bit Score: 40.76  E-value: 5.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 429 QELQQRNEVGRRLIAAQDAEREQLARElhdamgpnlaALHMAwQSEAVREALAAApkaRSIGQLTEEILGQLYEQVRQLS 508
Cdd:PRK07353  64 QQLASARKQAQAVIAEAEAEADKLAAE----------ALAEA-QAEAQASKEKAR---REIEQQKQAALAQLEQQVDALS 129


                 ....
gi 972942283 509 HALL 512
Cdd:PRK07353 130 RQIL 133
PRK10604 PRK10604
sensor protein RstB; Provisional
 561-644 6.31e-04

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 42.67  E-value: 6.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 561 RIVAELVNNAVRHAQaQQVEVQLRLHPEVLELCVEDDGRGF-----------------GRGEDAPITGIGLRGVRTRTAY 623
Cdd:PRK10604 322 RVLDNLLNNALRYAH-SRVRVSLLLDGNQACLIVEDDGPGIppeerervfepfvrldpSRDRATGGCGLGLAIVHSIALA 400

                         90       100
                 ....*....|....*....|..
gi 972942283 624 LGGTVNIE-SPGSGTRVVVRLP 644
Cdd:PRK10604 401 MGGSVNCDeSELGGARFSFSWP 422
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 566-644 6.70e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 39.35  E-value: 6.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 566 LVNNAVRHAQAQ-----QVEVQLRLHPEVLELCVEDDGRGF--------GRGEDaPITGIGLRGVRTRTAYLGG---TVN 629
Cdd:cd16924    9 LVENAIQHGLSPltdkgVVTISALKEDNHVMIEVEDNGRGIdpkvlnilGKKPK-EGNGIGLYNVHQRLILLFGedyGIH 87

                         90
                 ....*....|....*.
gi 972942283 630 IES-PGSGTRVVVRLP 644
Cdd:cd16924   88 IASePDKGTRITFTIP 103
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 611-644 1.31e-03

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 40.26  E-value: 1.31e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 972942283 611 GIGLRGVRTRTAYLGGTVNIES-PGSGTRVVVRLP 644
Cdd:cd16916  144 GVGMDVVKRSIESLGGTIEVESePGQGTTFTIRLP 178
PRK13560 PRK13560
hypothetical protein; Provisional
 442-644 1.61e-03

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 41.58  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 442 IAAQDAEREQLARELHDAMGPNLAALH--MAWQSEAVREALAAAPKARSIGQLTEEILG--QLYeQVRQLSHAllpaepg 517
Cdd:PRK13560 598 IKAALTEKEVLLKEIHHRVKNNLQIISslLDLQAEKLHDEEAKCAFAESQDRICAMALAheKLY-QSEDLADI------- 669

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 518 tnRLTRSVASLCEAL-NLNGTPRVITHF----DAGIDQLPQAVQSAAyrIVAELVNNAVRHA----QAQQVEVQLRLHPE 588
Cdd:PRK13560 670 --DFLDYIESLTAHLkNSFAIDFGRIDCkidaDDGCLDIDKAIPCGL--IISELLSNALKHAfpdgAAGNIKVEIREQGD 745

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 972942283 589 -VLELCVEDDGRGFGRGED-APITGIGLRGVRTRTAYLGGTVNIESPGsGTRVVVRLP 644
Cdd:PRK13560 746 gMVNLCVADDGIGLPAGFDfRAAETLGLQLVCALVKQLDGEIALDSRG-GARFNIRFP 802
PksD COG3321
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ...
 177-628 2.44e-03

Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442550 [Multi-domain]  Cd Length: 1386  Bit Score: 41.01  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  177 VYLPTYietaehflswemhfPFERHWVWLLGFYLGSALFNLVLFAFLRDRIHLWYGAYVVCVTLFLMMEDGLDAMLLPAG 256
Cdd:COG3321   861 VPLPTY--------------PFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAAL 926

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  257 LYRLIWSVGQYNFIVLAGAAGIRIMQLFLRLRSGWRGLYRAGNWLAGSAVAFVAVYAVLFPWAV--KHNLGLVEVLNGAR 334
Cdd:COG3321   927 AALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAaaAAALAAAAALALLA 1006

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  335 ELLVLLVFGYGWVTLLTVLIGRRRRRLAAYYALTYFFFFTGYAVFWLNHLGLTSYNPVYPNTLAWGLFVELLVLSALLTG 414
Cdd:COG3321  1007 AAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALAL 1086

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  415 RFRHTLRQNARLRIQELQQRNEVGRRLIAAQDAEREQLARELHDAMGPNLAALHMAWQSEAVREALAAAPKARSIGQLTE 494
Cdd:COG3321  1087 AAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAA 1166

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283  495 EILGQLYEQVRQLSHALLPAEPGTNRLTRSVASLCEALNLNGTPRVITHFDAGIDQLPQAVQSAAYRIVAELVNNAVRHA 574
Cdd:COG3321  1167 LLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVA 1246

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 972942283  575 QAQQVEVQLRLHPEVLELCVEDDGRGFGRGEDAPITGIGLRGVRTRTAYLGGTV 628
Cdd:COG3321  1247 ALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAA 1300
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
561-644 2.69e-03

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 40.53  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 561 RIVAELVNNAVRHAQA-QQVEVQLRLHPEVLELCVEDDG---------RGFGR-----------GEDapiTGIGLRGVRT 619
Cdd:PRK09835 378 RAISNLLSNALRYTPAgEAITVRCQEVDHQVQLVVENPGtpiapehlpRLFDRfyrvdpsrqrkGEG---SGIGLAIVKS 454

                         90       100
                 ....*....|....*....|....*
gi 972942283 620 RTAYLGGTVNIESPGSGTRVVVRLP 644
Cdd:PRK09835 455 IVVAHKGTVAVTSDARGTRFVISLP 479
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 562-645 2.70e-03

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 40.67  E-value: 2.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 562 IVAELVNNAVrHAQAQQ----VEVQLRLHPEVLELCVEDDGRGFGRGEDAPI-----------TGIGLRGVRTRTAYLGG 626
Cdd:PRK11086 437 ILGNLIENAL-EAVGGEeggeISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIfdkgystkgsnRGVGLYLVKQSVENLGG 515

                         90       100
                 ....*....|....*....|
gi 972942283 627 TVNIES-PGSGTRVVVRLPY 645
Cdd:PRK11086 516 SIAVESePGVGTQFFVQIPW 535
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
450-644 3.29e-03

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 40.55  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 450 EQLARELHDamgpnlaalhmawqsEAVREALAAApkaRSIGQLTEEilgqLYEQVRQLShaLLPAEPGTNRLTRSVASLC 529
Cdd:COG0643  197 EQLAEELED---------------ESLRELEEAL---EQLSRLTRE----LQDGVMRLR--MVPISTVFNRFPRMVRDLA 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 530 EALN----LngtprVITHFDAGIDqlpqavqsaayRIVAE--------LVNNAVRH--------------AQAQqveVQL 583
Cdd:COG0643  253 RELGkeveL-----VIEGEETELD-----------RTVLErlgdplvhLVRNAVDHgietpeerlaagkpETGT---ITL 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 584 RLHPE----VLElcVEDDGRGF---------------GRGEDAPIT-------------------------GIGLRGVRT 619
Cdd:COG0643  314 SAYHEggrvVIE--VSDDGRGLdlekirakaiekgliTAEEAAALSdeellelifapgfstaeevtdlsgrGVGMDVVKT 391

                        250       260
                 ....*....|....*....|....*.
gi 972942283 620 RTAYLGGTVNIES-PGSGTRVVVRLP 644
Cdd:COG0643  392 NIEALGGTIEIESePGKGTTFTLRLP 417
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
426-644 4.71e-03

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 40.05  E-value: 4.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 426 LRIQELQ-QRNEVGRRLiaaQDAEREQ--------LARELHDAMGPNLAALHMAWQSEAvrealAAAPKARSIGQLTE-- 494
Cdd:PRK13837 425 IERRRLEtERDALERRL---EHARRLEavgtlasgIAHNFNNILGAILGYAEMALNKLA-----RHSRAARYIDEIISag 496

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 495 ----EILGQLYEQVRQLSHALLPAEpgTNRLTRSVASLCEAlnlnGTPRVIT---HFDAGIDQL---PQAVQsaayRIVA 564
Cdd:PRK13837 497 ararLIIDQILAFGRKGERNTKPFD--LSELVTEIAPLLRV----SLPPGVEldfDQDQEPAVVegnPAELQ----QVLM 566

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972942283 565 ELVNNAvrhAQAQ----QVEVQLRLH----PEVLE-----------LCVEDDGRGFGRGEDAPI-----------TGIGL 614
Cdd:PRK13837 567 NLCSNA---AQAMdgagRVDISLSRAklraPKVLShgvlppgryvlLRVSDTGAGIDEAVLPHIfepffttraggTGLGL 643

                        250       260       270
                 ....*....|....*....|....*....|.
gi 972942283 615 RGVRTRTAYLGGTVNIES-PGSGTRVVVRLP 644
Cdd:PRK13837 644 ATVHGIVSAHAGYIDVQStVGRGTRFDVYLP 674
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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