NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|972319640|ref|WP_058976663|]
View 

MULTISPECIES: lysine biosynthesis protein LysW [Deinococcus]

Protein Classification

alpha-aminoadipate/glutamate carrier protein LysW( domain architecture ID 10018755)

alpha-aminoadipate/glutamate carrier protein LysW is a carrier protein that bears the covalently bound substrates for arginine and lysine biosynthesis; bound L-glutamate is sequentially converted to L-ornithine, while bound alpha-aminoadipate (AAA) is sequentially converted to L-lysine

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
lysW TIGR01206
lysine biosynthesis protein LysW; This very small, poorly characterized protein has been shown ...
 4-57 6.25e-20

lysine biosynthesis protein LysW; This very small, poorly characterized protein has been shown essential in Thermus thermophilus for an unusual pathway of Lys biosynthesis from aspartate by way of alpha-aminoadipate (AAA) rather than diaminopimelate. It is found also in Deinococcus radiodurans and Pyrococcus horikoshii, which appear to share the AAA pathway. [Amino acid biosynthesis, Aspartate family]


:

Pssm-ID: 273499 [Multi-domain]  Cd Length: 54  Bit Score: 73.78  E-value: 6.25e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 972319640   4 VQFENPDTGATIELTNPELGELVIDDETGVEYEVVSIDPPRLEAAPQEAEDWGE 57
Cdd:TIGR01206  1 MQFECPECGAEIELENPELGELVICDECGAELEVVSLDPLRLEAAPEEAEDWGE 54
 
Name Accession Description Interval E-value
lysW TIGR01206
lysine biosynthesis protein LysW; This very small, poorly characterized protein has been shown ...
 4-57 6.25e-20

lysine biosynthesis protein LysW; This very small, poorly characterized protein has been shown essential in Thermus thermophilus for an unusual pathway of Lys biosynthesis from aspartate by way of alpha-aminoadipate (AAA) rather than diaminopimelate. It is found also in Deinococcus radiodurans and Pyrococcus horikoshii, which appear to share the AAA pathway. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 273499 [Multi-domain]  Cd Length: 54  Bit Score: 73.78  E-value: 6.25e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 972319640   4 VQFENPDTGATIELTNPELGELVIDDETGVEYEVVSIDPPRLEAAPQEAEDWGE 57
Cdd:TIGR01206  1 MQFECPECGAEIELENPELGELVICDECGAELEVVSLDPLRLEAAPEEAEDWGE 54
LysW cd13946
Lysine biosynthesis protein LysW; LysW functions as a carrier protein in the biosynthesis ...
 9-57 3.90e-06

Lysine biosynthesis protein LysW; LysW functions as a carrier protein in the biosynthesis pathway of lysine. The C-terminal glutamate sidechain of LysW attaches to the amino group of alpha-aminoadipate (AAA); this peptide bond formation is catalyzed by the ligase LysX. AAA remains associated with LysW throughout its biosynthetic conversion to lysine. LysW also acts to protect the amino group of glutamate in arginine biosynthesis.


Pssm-ID: 260118 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 3.90e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 972319640  9 PDTGATIELTNPEL-GELVIDDETGVEYEVVSI-DPPRLEAAPQEAEDWGE 57
Cdd:cd13946   4 PECGAEIELPDDALvGEIVECPDCGAELEVVKLgDPVELKEAPEVEEDWGE 54
 
Name Accession Description Interval E-value
lysW TIGR01206
lysine biosynthesis protein LysW; This very small, poorly characterized protein has been shown ...
 4-57 6.25e-20

lysine biosynthesis protein LysW; This very small, poorly characterized protein has been shown essential in Thermus thermophilus for an unusual pathway of Lys biosynthesis from aspartate by way of alpha-aminoadipate (AAA) rather than diaminopimelate. It is found also in Deinococcus radiodurans and Pyrococcus horikoshii, which appear to share the AAA pathway. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 273499 [Multi-domain]  Cd Length: 54  Bit Score: 73.78  E-value: 6.25e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 972319640   4 VQFENPDTGATIELTNPELGELVIDDETGVEYEVVSIDPPRLEAAPQEAEDWGE 57
Cdd:TIGR01206  1 MQFECPECGAEIELENPELGELVICDECGAELEVVSLDPLRLEAAPEEAEDWGE 54
LysW cd13946
Lysine biosynthesis protein LysW; LysW functions as a carrier protein in the biosynthesis ...
 9-57 3.90e-06

Lysine biosynthesis protein LysW; LysW functions as a carrier protein in the biosynthesis pathway of lysine. The C-terminal glutamate sidechain of LysW attaches to the amino group of alpha-aminoadipate (AAA); this peptide bond formation is catalyzed by the ligase LysX. AAA remains associated with LysW throughout its biosynthetic conversion to lysine. LysW also acts to protect the amino group of glutamate in arginine biosynthesis.


Pssm-ID: 260118 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 3.90e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 972319640  9 PDTGATIELTNPEL-GELVIDDETGVEYEVVSI-DPPRLEAAPQEAEDWGE 57
Cdd:cd13946   4 PECGAEIELPDDALvGEIVECPDCGAELEVVKLgDPVELKEAPEVEEDWGE 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH