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Conserved domains on  [gi|971750035|ref|YP_009204184|]
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anti-restriction protein [Mycobacterium phage Smeadley]

Protein Classification

antirestriction protein ArdA( domain architecture ID 10538058)

antirestriction protein ArdA allows associated mobile genetic elements to evade the ubiquitous Type I DNA restriction systems, assisting in the spread of resistance genes in bacteria

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArdA super family cl01953
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 3-163 2.42e-41

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


The actual alignment was detected with superfamily member COG4734:

Pssm-ID: 470408  Cd Length: 173  Bit Score: 136.99  E-value: 2.42e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971750035   3 RIYVADLAAYNAGVLHGEWIDLNgRDSEEVWAEVKAMLAEGQKLYVsktlgvhEEWAIHDYEGFGSLRIGEYEDIDQLID 82
Cdd:COG4734    9 RIYVACLAAYNNGSLHGKWIDAT-QDVEEIQEAIREMLADSPVEDA-------EEWAIHDYEGFPGATISEYESLEKVFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971750035  83 LADALEKHGEPFEAWLSeiigdigYFASVSDAEDQFEDRFIG-AVTKEDYAYDYAEDVLGLTGV---ALDYFDYEKFARD 158
Cdd:COG4734   81 LAEFIEEHGEAFAAWLD-------HFGGLEDAEEAFEDAYQGeYDSEADFAEELIEETGLLLEIpesLARYIDYEAYARD 153


                 ....*
gi 971750035 159 LELSG 163
Cdd:COG4734  154 LFLSD 158
 
Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
3-163 2.42e-41

Antirestriction protein ArdA [Defense mechanisms];


Pssm-ID: 443768  Cd Length: 173  Bit Score: 136.99  E-value: 2.42e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971750035   3 RIYVADLAAYNAGVLHGEWIDLNgRDSEEVWAEVKAMLAEGQKLYVsktlgvhEEWAIHDYEGFGSLRIGEYEDIDQLID 82
Cdd:COG4734    9 RIYVACLAAYNNGSLHGKWIDAT-QDVEEIQEAIREMLADSPVEDA-------EEWAIHDYEGFPGATISEYESLEKVFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971750035  83 LADALEKHGEPFEAWLSeiigdigYFASVSDAEDQFEDRFIG-AVTKEDYAYDYAEDVLGLTGV---ALDYFDYEKFARD 158
Cdd:COG4734   81 LAEFIEEHGEAFAAWLD-------HFGGLEDAEEAFEDAYQGeYDSEADFAEELIEETGLLLEIpesLARYIDYEAYARD 153


                 ....*
gi 971750035 159 LELSG 163
Cdd:COG4734  154 LFLSD 158
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 4-166 5.64e-27

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


Pssm-ID: 462130  Cd Length: 151  Bit Score: 99.62  E-value: 5.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971750035    4 IYVADLAAYNAGVLHGEWIDLNgRDSEEVWAEVKAMLAEGQklyvsktlgVHEEWAIHDYEGFGSLrIGEYEDIDQLIDL 83
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLP-ADAEELQEALRRIGAEGE---------EYEEYAIHDYEGFGFT-LGEYESIDELNEL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971750035   84 ADALEKHGEPfeawlseiigdigyfaSVSDAEDQFEDRFIGAV----TKEDYAYDYAEDVLGLTGVA---LDYFDYEKFA 156
Cdd:pfam07275  70 AALLEELAEH----------------DLEEFEAAFEERYAGEYdsliQNLDYAYYYVEELGELDEIPeelENYFDYEAYG 133

                         170
                  ....*....|
gi 971750035  157 RDLELSGDIS 166
Cdd:pfam07275 134 RDLFLDGDGV 143
 
Name Accession Description Interval E-value
ArdA COG4734
Antirestriction protein ArdA [Defense mechanisms];
3-163 2.42e-41

Antirestriction protein ArdA [Defense mechanisms];


Pssm-ID: 443768  Cd Length: 173  Bit Score: 136.99  E-value: 2.42e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971750035   3 RIYVADLAAYNAGVLHGEWIDLNgRDSEEVWAEVKAMLAEGQKLYVsktlgvhEEWAIHDYEGFGSLRIGEYEDIDQLID 82
Cdd:COG4734    9 RIYVACLAAYNNGSLHGKWIDAT-QDVEEIQEAIREMLADSPVEDA-------EEWAIHDYEGFPGATISEYESLEKVFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971750035  83 LADALEKHGEPFEAWLSeiigdigYFASVSDAEDQFEDRFIG-AVTKEDYAYDYAEDVLGLTGV---ALDYFDYEKFARD 158
Cdd:COG4734   81 LAEFIEEHGEAFAAWLD-------HFGGLEDAEEAFEDAYQGeYDSEADFAEELIEETGLLLEIpesLARYIDYEAYARD 153


                 ....*
gi 971750035 159 LELSG 163
Cdd:COG4734  154 LFLSD 158
ArdA pfam07275
Antirestriction protein (ArdA); This family consists of several bacterial antirestriction ...
 4-166 5.64e-27

Antirestriction protein (ArdA); This family consists of several bacterial antirestriction (ArdA) proteins. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification.


Pssm-ID: 462130  Cd Length: 151  Bit Score: 99.62  E-value: 5.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971750035    4 IYVADLAAYNAGVLHGEWIDLNgRDSEEVWAEVKAMLAEGQklyvsktlgVHEEWAIHDYEGFGSLrIGEYEDIDQLIDL 83
Cdd:pfam07275   1 IYVANLAKYNNGELVGEWLDLP-ADAEELQEALRRIGAEGE---------EYEEYAIHDYEGFGFT-LGEYESIDELNEL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971750035   84 ADALEKHGEPfeawlseiigdigyfaSVSDAEDQFEDRFIGAV----TKEDYAYDYAEDVLGLTGVA---LDYFDYEKFA 156
Cdd:pfam07275  70 AALLEELAEH----------------DLEEFEAAFEERYAGEYdsliQNLDYAYYYVEELGELDEIPeelENYFDYEAYG 133

                         170
                  ....*....|
gi 971750035  157 RDLELSGDIS 166
Cdd:pfam07275 134 RDLFLDGDGV 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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