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Conserved domains on  [gi|966689743|gb|KTG22575|]
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hypothetical protein AUR67_00260 [Pseudoalteromonas sp. XI10]

Protein Classification

type I DNA topoisomerase( domain architecture ID 11425664)

DNA topoisomerase I is a type IA DNA topoisomerase that releases the supercoiling and torsional tension of DNA, which is introduced during DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex

EC:  5.6.2.1
Gene Ontology:  GO:0003917
PubMed:  19208647

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 2-185 6.46e-45

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


:

Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 157.33  E-value: 6.46e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743   2 SKIDHSLFSADKHALEKEYEVCPKCGSELVMRNSKSGPFLGCASYPKCDFIRPLAhhdsqqiKVLEDSACPECGKPLVIK 81
Cdd:COG0551  527 KLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLEIAEEEGEEELSEE-------DEVLGEKCPKCGKPLVIK 599

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  82 NGRYGMFIGCTGYPECHYIAHDEEPDDAPQlpACPKCKKgQLVARNNKFGKTFYSCDGYPRCKYTLNHKPVATECPACQW 161
Cdd:COG0551  600 KGRYGKFLGCSNYPECKYTKPLPKPEVTGV--KCPKCGK-KLVLRKSKKGKVFYGCSNYPKCKFTEWDKPVKEPCPKCGS 676

                        170       180
                 ....*....|....*....|....
gi 966689743 162 PiMTEKKTASGvvlqCPQKSCMHK 185
Cdd:COG0551  677 P-LVEKKTKKG----CANKLCGYE 695
 
Name Accession Description Interval E-value
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 2-185 6.46e-45

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 157.33  E-value: 6.46e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743   2 SKIDHSLFSADKHALEKEYEVCPKCGSELVMRNSKSGPFLGCASYPKCDFIRPLAhhdsqqiKVLEDSACPECGKPLVIK 81
Cdd:COG0551  527 KLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLEIAEEEGEEELSEE-------DEVLGEKCPKCGKPLVIK 599

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  82 NGRYGMFIGCTGYPECHYIAHDEEPDDAPQlpACPKCKKgQLVARNNKFGKTFYSCDGYPRCKYTLNHKPVATECPACQW 161
Cdd:COG0551  600 KGRYGKFLGCSNYPECKYTKPLPKPEVTGV--KCPKCGK-KLVLRKSKKGKVFYGCSNYPKCKFTEWDKPVKEPCPKCGS 676

                        170       180
                 ....*....|....*....|....
gi 966689743 162 PiMTEKKTASGvvlqCPQKSCMHK 185
Cdd:COG0551  677 P-LVEKKTKKG----CANKLCGYE 695
PRK06599 PRK06599
DNA topoisomerase I; Validated
 12-106 1.78e-30

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 116.50  E-value: 1.78e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  12 DKHALEKEYEVCPKC-GSELVMRNSKSGPFLGCASYPKCDFIRPLAHHDSQQIKVLEDSA---CPECGKPLVIKNGRYGM 87
Cdd:PRK06599 577 EKVTQEETDETCPKCgGGPLVLKLGKNGKFLGCSGYPECKYTKNITRDEDEPIEEEEIVEeekCPKCGGPLVLKKGRYGK 656

                         90
                 ....*....|....*....
gi 966689743  88 FIGCTGYPECHYIAHDEEP 106
Cdd:PRK06599 657 FLACSGYPECKHIKPLEKP 675
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
71-100 1.25e-09

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 51.49  E-value: 1.25e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 966689743   71 CPECGKPLVIKNGRYGMFIGCTGYPECHYI 100
Cdd:pfam01396   4 CPKCGGDLVLKRGRFGKFVGCSNYPECRFT 33
topA_arch TIGR01057
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ...
 70-97 1.03e-04

DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273420 [Multi-domain]  Cd Length: 618  Bit Score: 42.12  E-value: 1.03e-04
                          10        20
                  ....*....|....*....|....*...
gi 966689743   70 ACPECGKPLVIKNGRYGMFIGCTGYPEC 97
Cdd:TIGR01057 591 KCPKCGGKLVSKYAKKGRFVGCSNYPEC 618
 
Name Accession Description Interval E-value
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 2-185 6.46e-45

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 157.33  E-value: 6.46e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743   2 SKIDHSLFSADKHALEKEYEVCPKCGSELVMRNSKSGPFLGCASYPKCDFIRPLAhhdsqqiKVLEDSACPECGKPLVIK 81
Cdd:COG0551  527 KLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLEIAEEEGEEELSEE-------DEVLGEKCPKCGKPLVIK 599

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  82 NGRYGMFIGCTGYPECHYIAHDEEPDDAPQlpACPKCKKgQLVARNNKFGKTFYSCDGYPRCKYTLNHKPVATECPACQW 161
Cdd:COG0551  600 KGRYGKFLGCSNYPECKYTKPLPKPEVTGV--KCPKCGK-KLVLRKSKKGKVFYGCSNYPKCKFTEWDKPVKEPCPKCGS 676

                        170       180
                 ....*....|....*....|....
gi 966689743 162 PiMTEKKTASGvvlqCPQKSCMHK 185
Cdd:COG0551  677 P-LVEKKTKKG----CANKLCGYE 695
PRK06599 PRK06599
DNA topoisomerase I; Validated
 12-106 1.78e-30

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 116.50  E-value: 1.78e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  12 DKHALEKEYEVCPKC-GSELVMRNSKSGPFLGCASYPKCDFIRPLAHHDSQQIKVLEDSA---CPECGKPLVIKNGRYGM 87
Cdd:PRK06599 577 EKVTQEETDETCPKCgGGPLVLKLGKNGKFLGCSGYPECKYTKNITRDEDEPIEEEEIVEeekCPKCGGPLVLKKGRYGK 656

                         90
                 ....*....|....*....
gi 966689743  88 FIGCTGYPECHYIAHDEEP 106
Cdd:PRK06599 657 FLACSGYPECKHIKPLEKP 675
PRK06319 PRK06319
DNA topoisomerase I/SWI domain fusion protein; Validated
 23-148 3.79e-29

DNA topoisomerase I/SWI domain fusion protein; Validated


Pssm-ID: 235778 [Multi-domain]  Cd Length: 860  Bit Score: 112.99  E-value: 3.79e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  23 CPKC-GSELVMRNSKSGPFLGCASYPKCDFIRP----LAHHDSQQIKVLEDSACPECGKPLVIKNGRYGMFIGCTGYPEC 97
Cdd:PRK06319 595 CPKChKGKLVKIWAKNRYFYGCSEYPECDYKTSeeelTFNKEDYAEDTPWDSPCPLCGGEMKVRHGRFGTFLGCENYPEC 674

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966689743  98 HYIAH----DEEPDDAPQLPACPK--CkKGQLVARNNKFGKTFYSCDGYPRCKYTLN 148
Cdd:PRK06319 675 RGIINihkkGEEGIEPEETVPCPAigC-TGHIVKRRSRFNKMFYSCSEYPACSVIGN 730
PRK07219 PRK07219
DNA topoisomerase I; Validated
 23-163 8.56e-27

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 106.24  E-value: 8.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  23 CPKCGSELVMRNSKSGP-FLGCASYPKCDFIRPLAhhDSQQIKVLeDSACPECGKPLV-IKNGRYGMFIGCtgyPECHYi 100
Cdd:PRK07219 605 CPECGGDLIIIRTDKGSrFVGCSGYPDCRNTFPLP--STGRIKVL-DEVCEKCGLPVIkILRGKQTFVVGC---PDCEA- 677

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966689743 101 aHDEEPDDAPQLPACPKCKkGQLVARNNKFGKtFYSCDGYPRCKYTL------NHKPVATECPACQWPI 163
Cdd:PRK07219 678 -EKEEEDPDEVIGPCPKCG-GELAIKQLKYGS-FLGCTNYPKCKYTLplprrgKITVTDEKCPECGLPL 743
PRK06599 PRK06599
DNA topoisomerase I; Validated
 67-146 1.03e-22

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 94.54  E-value: 1.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  67 EDSACPEC-GKPLVIKNGRYGMFIGCTGYPECHYI-------AHDEEPDDAPQLPACPKCKkGQLVARNNKFGKtFYSCD 138
Cdd:PRK06599 584 TDETCPKCgGGPLVLKLGKNGKFLGCSGYPECKYTknitrdeDEPIEEEEIVEEEKCPKCG-GPLVLKKGRYGK-FLACS 661


                 ....*...
gi 966689743 139 GYPRCKYT 146
Cdd:PRK06599 662 GYPECKHI 669
PRK07219 PRK07219
DNA topoisomerase I; Validated
 17-99 1.72e-20

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 88.13  E-value: 1.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  17 EKEYEVCPKCGSELVMRNSKSGPFLGCASYPKCDFIRPLahHDSQQIKVLeDSACPECGKPLVIKNGRYGMFIGCTGYPE 96
Cdd:PRK07219 685 DEVIGPCPKCGGELAIKQLKYGSFLGCTNYPKCKYTLPL--PRRGKITVT-DEKCPECGLPLLRVKGGFGDELGCCNNPK 761


                 ...
gi 966689743  97 CHY 99
Cdd:PRK07219 762 CNY 764
PRK07219 PRK07219
DNA topoisomerase I; Validated
 21-146 1.25e-17

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 79.66  E-value: 1.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  21 EVCPKCGSELV-MRNSKSGPFLGCasyPKCDFirplahHDSQQIKVLEDSACPECGKPLVIKNGRYGMFIGCTGYPECHY 99
Cdd:PRK07219 649 EVCEKCGLPVIkILRGKQTFVVGC---PDCEA------EKEEEDPDEVIGPCPKCGGELAIKQLKYGSFLGCTNYPKCKY 719

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966689743 100 I------AHDEEPDDapqlpACPKCkKGQLVARNNKFGKtFYSCDGYPRCKYT 146
Cdd:PRK07219 720 TlplprrGKITVTDE-----KCPEC-GLPLLRVKGGFGD-ELGCCNNPKCNYT 765
PRK07561 PRK07561
DNA topoisomerase I subunit omega; Validated
 21-144 3.94e-14

DNA topoisomerase I subunit omega; Validated


Pssm-ID: 236048 [Multi-domain]  Cd Length: 859  Bit Score: 69.82  E-value: 3.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  21 EVCPKCGSELVMRNSKSGPFLGCASY---PKCDFIRPLAHHDSQQIKVLEDSAC-------PECGKPLVIKNGRYGMFIG 90
Cdd:PRK07561 588 RDCPTCGRGMGIRTGKTGVFLGCSGYalkERCKTTRNLTPEEETLNVLEGEDAEtralgadPECGTAMVLRSGRFGPYVQ 667

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966689743  91 ------------CTGY-PEChyIAHDEEpDDAPQLP----ACPKCKKgQLVARNNKFGKtFYSCDG-YPRCK 144
Cdd:PRK07561 668 egegdkprrlslPKGNnPEC--VGLEIA-LGLLSLPrpvgEHPECGS-EIQAKIGRFGP-YVKCGGtYASLK 734
PRK07220 PRK07220
DNA topoisomerase I; Validated
 23-100 7.25e-12

DNA topoisomerase I; Validated


Pssm-ID: 180892 [Multi-domain]  Cd Length: 740  Bit Score: 63.24  E-value: 7.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  23 CPKCGSELVMRNSKSGP-FLGCASYPKCDFIRPLAHhdSQQIKVLeDSACPECGKP--LVIKNGRYGMFIGCtgyPECHY 99
Cdd:PRK07220 592 CPLCGSDLMVRRSKRGSrFIGCEGYPECTFSLPLPK--SGQIIVT-DKVCEAHGLNhiRIINGGKRPWDLGC---PQCNF 665


                 .
gi 966689743 100 I 100
Cdd:PRK07220 666 I 666
PRK07561 PRK07561
DNA topoisomerase I subunit omega; Validated
 62-131 3.68e-10

DNA topoisomerase I subunit omega; Validated


Pssm-ID: 236048 [Multi-domain]  Cd Length: 859  Bit Score: 58.27  E-value: 3.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  62 QIKVLEDSACPECGKPLVIKNGRYGMFIGCTGY---PECHY-----------IAHDEEPDDAPQLPACPKCKKgQLVARN 127
Cdd:PRK07561 581 NQMVITDRDCPTCGRGMGIRTGKTGVFLGCSGYalkERCKTtrnltpeeetlNVLEGEDAETRALGADPECGT-AMVLRS 659


                 ....
gi 966689743 128 NKFG 131
Cdd:PRK07561 660 GRFG 663
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
71-100 1.25e-09

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 51.49  E-value: 1.25e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 966689743   71 CPECGKPLVIKNGRYGMFIGCTGYPECHYI 100
Cdd:pfam01396   4 CPKCGGDLVLKRGRFGKFVGCSNYPECRFT 33
COG1754 COG1754
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
18-86 3.77e-09

Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];


Pssm-ID: 441360 [Multi-domain]  Cd Length: 892  Bit Score: 55.21  E-value: 3.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  18 KEYEVCPKCGSELVMRNSKSGPFLGC-------ASYPKCDFIRPLAHHDSQQI--------KVL-EDsacPECGKPLVIK 81
Cdd:COG1754  600 REINSCPLGTGGLSLRVGRYGPFIECsnyeprrASIPECLAPDELTPEKAEELleapadgpRVLgTD---PETGKPIVLK 676


                 ....*
gi 966689743  82 NGRYG 86
Cdd:COG1754  677 DGRFG 681
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
21-55 1.20e-08

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 48.79  E-value: 1.20e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 966689743   21 EVCPKCGSELVMRNSKSGPFLGCASYPKCDFIRPL 55
Cdd:pfam01396   2 GKCPKCGGDLVLKRGRFGKFVGCSNYPECRFTRPL 36
PRK06599 PRK06599
DNA topoisomerase I; Validated
 115-177 2.74e-08

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 52.55  E-value: 2.74e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966689743 115 CPKCKKGQLVARNNKFGKtFYSCDGYPRCKYTLN-----HKPVATE-------CPACQWPIMTeKKTASGVVLQC 177
Cdd:PRK06599 588 CPKCGGGPLVLKLGKNGK-FLGCSGYPECKYTKNitrdeDEPIEEEeiveeekCPKCGGPLVL-KKGRYGKFLAC 660
PRK07561 PRK07561
DNA topoisomerase I subunit omega; Validated
 15-91 9.54e-08

DNA topoisomerase I subunit omega; Validated


Pssm-ID: 236048 [Multi-domain]  Cd Length: 859  Bit Score: 50.95  E-value: 9.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  15 ALEKEYEVCPKCGSELVMRNSKSGPFLGCAS-YPKCD---------FIRPLAHHDSQQI-----KVLEDSACPECGKPLV 79
Cdd:PRK07561 698 SLPRPVGEHPECGSEIQAKIGRFGPYVKCGGtYASLKntrkvltigLNRAVELLAEPKRpkedpVPLPELGCPKSGAPFV 777

                         90
                 ....*....|..
gi 966689743  80 IKNGRYGMFIGC 91
Cdd:PRK07561 778 LRDGRYGPYVKH 789
PRK07726 PRK07726
DNA topoisomerase 3;
62-120 2.50e-07

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 49.78  E-value: 2.50e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 966689743  62 QIKVLEDSACPECGKPLVIKNGRYGMFIGCTGYPECHYiahdeEPDDAPQLPACPKCKK 120
Cdd:PRK07726 604 KFDNLTGPKCPDCGKPMLKVKGKNGKMLVCQDRECGKR-----KNVSKKTNARCPNCKK 657
PRK14973 PRK14973
DNA topoisomerase I; Provisional
 71-99 8.21e-07

DNA topoisomerase I; Provisional


Pssm-ID: 184936 [Multi-domain]  Cd Length: 936  Bit Score: 48.30  E-value: 8.21e-07
                         10        20
                 ....*....|....*....|....*....
gi 966689743  71 CPECGKPLVIKNGRYGMFIGCTGYPECHY 99
Cdd:PRK14973 591 CPVCGKDLRIKHIGSSQFIGCSGYPDCTF 619
PRK14973 PRK14973
DNA topoisomerase I; Provisional
 23-105 4.87e-06

DNA topoisomerase I; Provisional


Pssm-ID: 184936 [Multi-domain]  Cd Length: 936  Bit Score: 45.99  E-value: 4.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689743  23 CPKCGSELVMRNSKSGPFLGCASYPKCDF--IRPLAHHDSqQIKVleDSACPECGKPLV--IKNGRYGMFIGCtgyPECH 98
Cdd:PRK14973 591 CPVCGKDLRIKHIGSSQFIGCSGYPDCTFniGLPGTTWGW-AIRT--DEVCPIHHLNHVrlIRKGARPWDIGC---PLCS 664


                 ....*..
gi 966689743  99 YIAHDEE 105
Cdd:PRK14973 665 HIESNTE 671
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
115-151 7.80e-06

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 41.09  E-value: 7.80e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 966689743  115 CPKCKkGQLVARNNKFGKtFYSCDGYPRCKYTLNHKP 151
Cdd:pfam01396   4 CPKCG-GDLVLKRGRFGK-FVGCSNYPECRFTRPLKK 38
PRK07219 PRK07219
DNA topoisomerase I; Validated
 16-51 3.40e-05

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 43.45  E-value: 3.40e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 966689743  16 LEKEYEVCPKCGSELVMRNSKSGPFLGCASYPKCDF 51
Cdd:PRK07219 729 ITVTDEKCPECGLPLLRVKGGFGDELGCCNNPKCNY 764
topA_arch TIGR01057
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ...
 70-97 1.03e-04

DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273420 [Multi-domain]  Cd Length: 618  Bit Score: 42.12  E-value: 1.03e-04
                          10        20
                  ....*....|....*....|....*...
gi 966689743   70 ACPECGKPLVIKNGRYGMFIGCTGYPEC 97
Cdd:TIGR01057 591 KCPKCGGKLVSKYAKKGRFVGCSNYPEC 618
PRK07220 PRK07220
DNA topoisomerase I; Validated
 115-147 2.78e-04

DNA topoisomerase I; Validated


Pssm-ID: 180892 [Multi-domain]  Cd Length: 740  Bit Score: 40.90  E-value: 2.78e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 966689743 115 CPKCKKgQLVARNNKFGKTFYSCDGYPRCKYTL 147
Cdd:PRK07220 592 CPLCGS-DLMVRRSKRGSRFIGCEGYPECTFSL 623
PRK07726 PRK07726
DNA topoisomerase 3;
108-160 2.83e-04

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 40.53  E-value: 2.83e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966689743 108 DAPQLPACPKCKKGQLvARNNKFGKtFYSCDGYPRCKYTLNHKPVATECPACQ 160
Cdd:PRK07726 606 DNLTGPKCPDCGKPML-KVKGKNGK-MLVCQDRECGKRKNVSKKTNARCPNCK 656
COG1754 COG1754
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
67-99 5.55e-03

Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];


Pssm-ID: 441360 [Multi-domain]  Cd Length: 892  Bit Score: 37.10  E-value: 5.55e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 966689743  67 EDSACPECGKPLVIKNGRYGMFIGCTGY-------PECHY 99
Cdd:COG1754  601 EINSCPLGTGGLSLRVGRYGPFIECSNYeprrasiPECLA 640
PRK07726 PRK07726
DNA topoisomerase 3;
23-49 6.50e-03

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 36.68  E-value: 6.50e-03
                         10        20
                 ....*....|....*....|....*..
gi 966689743  23 CPKCGSELVMRNSKSGPFLGCASYPKC 49
Cdd:PRK07726 613 CPDCGKPMLKVKGKNGKMLVCQDRECG 639
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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