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Conserved domains on  [gi|966689736|gb|KTG22568|]
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potassium transporter peripheral membrane component [Pseudoalteromonas sp. XI10]

Protein Classification

Trk system potassium transport protein TrkA( domain architecture ID 11484302)

Trk system potassium transport protein TrkA may regulate the transport activity of the constitutive potassium transport TrkG and TrkH systems; binds to NAD(+) and NADH

Gene Ontology:  GO:0006813

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trkA PRK09496
Trk system potassium transporter TrkA;
1-455 0e+00

Trk system potassium transporter TrkA;


:

Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 682.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736   1 MKIIILGAGQVGGTLAENLVGEQNEITVVDIDGNRLRELQDKYDLQGVTGHSAHPDVLRRAGAEDADMIIAVTSSDEVNM 80
Cdd:PRK09496   1 MKIIIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDRLDVRTVVGNGSSPDVLREAGAEDADLLIAVTDSDETNM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736  81 VACQVAYSIFNTPTKIARIRSEQYLKYREkLFHNDDLPVDHYIAPEALVTKYIRRLIDYPGALQVLQFADGMLSLVAVKA 160
Cdd:PRK09496  81 VACQIAKSLFGAPTTIARVRNPEYAEYDK-LFSKEALGIDLLISPELLVAREIARLIEYPGALDVEEFADGRVQLVEVKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 161 YYGGLLVGYALSALKEHIPNVETRVAAIYRQGKAIKPLGTTVIEADDEVFFIAATKHIRAVMNELQKLERSYKKIMIAGG 240
Cdd:PRK09496 160 YEGSPLVGKPLSDLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEFGRLEKPVKRVMIVGG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 241 GNIGAGLARSLEK-NHSVKLLERNKERAAQLSEMLDNTVVFCGDASDQELLSEEHIEQVDVFIAVTNDDEANIMSAMLAK 319
Cdd:PRK09496 240 GNIGYYLAKLLEKeGYSVKLIERDPERAEELAEELPNTLVLHGDGTDQELLEEEGIDEADAFIALTNDDEANILSSLLAK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 320 RMGAQKTMVLIQRGAYVDLVQGGEIDIAISPQQATISALLTHVRRGDIVNVYSLRKGAAEAIEAVAHgdeHTSKVVGRAI 399
Cdd:PRK09496 320 RLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAEAIEAVAH---ETSKVVGKPL 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689736 400 ADIKLPAGTTIGAIVRNDDVLIAHDDTVIQSGDHVIMFLIDKKHITVVEKLFQVSA 455
Cdd:PRK09496 397 KDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDKKFVPDVEKLFQVSP 452
 
Name Accession Description Interval E-value
trkA PRK09496
Trk system potassium transporter TrkA;
1-455 0e+00

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 682.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736   1 MKIIILGAGQVGGTLAENLVGEQNEITVVDIDGNRLRELQDKYDLQGVTGHSAHPDVLRRAGAEDADMIIAVTSSDEVNM 80
Cdd:PRK09496   1 MKIIIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDRLDVRTVVGNGSSPDVLREAGAEDADLLIAVTDSDETNM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736  81 VACQVAYSIFNTPTKIARIRSEQYLKYREkLFHNDDLPVDHYIAPEALVTKYIRRLIDYPGALQVLQFADGMLSLVAVKA 160
Cdd:PRK09496  81 VACQIAKSLFGAPTTIARVRNPEYAEYDK-LFSKEALGIDLLISPELLVAREIARLIEYPGALDVEEFADGRVQLVEVKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 161 YYGGLLVGYALSALKEHIPNVETRVAAIYRQGKAIKPLGTTVIEADDEVFFIAATKHIRAVMNELQKLERSYKKIMIAGG 240
Cdd:PRK09496 160 YEGSPLVGKPLSDLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEFGRLEKPVKRVMIVGG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 241 GNIGAGLARSLEK-NHSVKLLERNKERAAQLSEMLDNTVVFCGDASDQELLSEEHIEQVDVFIAVTNDDEANIMSAMLAK 319
Cdd:PRK09496 240 GNIGYYLAKLLEKeGYSVKLIERDPERAEELAEELPNTLVLHGDGTDQELLEEEGIDEADAFIALTNDDEANILSSLLAK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 320 RMGAQKTMVLIQRGAYVDLVQGGEIDIAISPQQATISALLTHVRRGDIVNVYSLRKGAAEAIEAVAHgdeHTSKVVGRAI 399
Cdd:PRK09496 320 RLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAEAIEAVAH---ETSKVVGKPL 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689736 400 ADIKLPAGTTIGAIVRNDDVLIAHDDTVIQSGDHVIMFLIDKKHITVVEKLFQVSA 455
Cdd:PRK09496 397 KDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDKKFVPDVEKLFQVSP 452
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 139-435 4.29e-63

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 206.07  E-value: 4.29e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 139 YPGALQVLQFADGMLSLVAVKAYYGGLLVGYALSALKEHIPNVETRVAAIYRQGKAIKPLGTTVIEADDEVFFIAATKHI 218
Cdd:COG0569    3 ILLLLLVLLFAMGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLEAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 219 RAVMNELQKLERSyKKIMIAGGGNIGAGLARSLEK-NHSVKLLERNKERAAQLSEmlDNTVVFCGDASDQELLSEEHIEQ 297
Cdd:COG0569   83 RRRRMERGIKKLK-MHVIIIGAGRVGRSLARELEEeGHDVVVIDKDPERVERLAE--EDVLVIVGDATDEEVLEEAGIED 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 298 VDVFIAVTNDDEANIMSAMLAKRMGAQKTMVLIQRGAYVDLVQGGEIDIAISPQQATISALLTHVRRGDIVNVYSLRKGA 377
Cdd:COG0569  160 ADAVIAATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADGD 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 378 AEAIEAVAHGDehtSKVVGRAIADIKLPA--GTTIGAIVRNDDVLIAHDDTVIQSGDHVI 435
Cdd:COG0569  240 AEIVEVTVPEG---SPLVGKTLKELDLREryGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 3-111 1.40e-23

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 94.90  E-value: 1.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736    3 IIILGAGQVGGTLAENLVgEQNEITVVDIDGNRLRELQDKYdLQGVTGHSAHPDVLRRAGAEDADMIIAVTSSDEVNMVA 82
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELS-EGGDVVVIDKDEERVEELREEG-VPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILI 78

                          90       100
                  ....*....|....*....|....*....
gi 966689736   83 CQVAYSIFNTPTKIARIRSEQYLKYREKL 111
Cdd:pfam02254  79 VLLARELNPDKKIIARANDPEHAELLRRL 107
L-AlaDH cd05305
Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) ...
 2-72 1.66e-06

Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.


Pssm-ID: 240630 [Multi-domain]  Cd Length: 359  Bit Score: 50.10  E-value: 1.66e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966689736   2 KIIILGAGQVGGTLAENLVGEQNEITVVDIDGNRLRELQDKYDlQGVTGHSAHPDVLRRAgAEDADMII-AV 72
Cdd:cd05305  170 KVVILGAGVVGENAARVALGLGAEVTVLDINLERLRYLDDIFG-GRVTTLYSNPANLEEA-LKEADLVIgAV 239
 
Name Accession Description Interval E-value
trkA PRK09496
Trk system potassium transporter TrkA;
1-455 0e+00

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 682.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736   1 MKIIILGAGQVGGTLAENLVGEQNEITVVDIDGNRLRELQDKYDLQGVTGHSAHPDVLRRAGAEDADMIIAVTSSDEVNM 80
Cdd:PRK09496   1 MKIIIVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDRLDVRTVVGNGSSPDVLREAGAEDADLLIAVTDSDETNM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736  81 VACQVAYSIFNTPTKIARIRSEQYLKYREkLFHNDDLPVDHYIAPEALVTKYIRRLIDYPGALQVLQFADGMLSLVAVKA 160
Cdd:PRK09496  81 VACQIAKSLFGAPTTIARVRNPEYAEYDK-LFSKEALGIDLLISPELLVAREIARLIEYPGALDVEEFADGRVQLVEVKV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 161 YYGGLLVGYALSALKEHIPNVETRVAAIYRQGKAIKPLGTTVIEADDEVFFIAATKHIRAVMNELQKLERSYKKIMIAGG 240
Cdd:PRK09496 160 YEGSPLVGKPLSDLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEFGRLEKPVKRVMIVGG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 241 GNIGAGLARSLEK-NHSVKLLERNKERAAQLSEMLDNTVVFCGDASDQELLSEEHIEQVDVFIAVTNDDEANIMSAMLAK 319
Cdd:PRK09496 240 GNIGYYLAKLLEKeGYSVKLIERDPERAEELAEELPNTLVLHGDGTDQELLEEEGIDEADAFIALTNDDEANILSSLLAK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 320 RMGAQKTMVLIQRGAYVDLVQGGEIDIAISPQQATISALLTHVRRGDIVNVYSLRKGAAEAIEAVAHgdeHTSKVVGRAI 399
Cdd:PRK09496 320 RLGAKKVIALVNRPAYVDLVEGLGIDIAISPRQATASEILRHVRRGDIVAVHSLRRGAAEAIEAVAH---ETSKVVGKPL 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689736 400 ADIKLPAGTTIGAIVRNDDVLIAHDDTVIQSGDHVIMFLIDKKHITVVEKLFQVSA 455
Cdd:PRK09496 397 KDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDKKFVPDVEKLFQVSP 452
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 139-435 4.29e-63

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 206.07  E-value: 4.29e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 139 YPGALQVLQFADGMLSLVAVKAYYGGLLVGYALSALKEHIPNVETRVAAIYRQGKAIKPLGTTVIEADDEVFFIAATKHI 218
Cdd:COG0569    3 ILLLLLVLLFAMGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLEAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 219 RAVMNELQKLERSyKKIMIAGGGNIGAGLARSLEK-NHSVKLLERNKERAAQLSEmlDNTVVFCGDASDQELLSEEHIEQ 297
Cdd:COG0569   83 RRRRMERGIKKLK-MHVIIIGAGRVGRSLARELEEeGHDVVVIDKDPERVERLAE--EDVLVIVGDATDEEVLEEAGIED 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 298 VDVFIAVTNDDEANIMSAMLAKRMGAQKTMVLIQRGAYVDLVQGGEIDIAISPQQATISALLTHVRRGDIVNVYSLRKGA 377
Cdd:COG0569  160 ADAVIAATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADGD 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 378 AEAIEAVAHGDehtSKVVGRAIADIKLPA--GTTIGAIVRNDDVLIAHDDTVIQSGDHVI 435
Cdd:COG0569  240 AEIVEVTVPEG---SPLVGKTLKELDLREryGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 1-210 3.55e-51

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 174.87  E-value: 3.55e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736   1 MKIIILGAGQVGGTLAENLVGEQNEITVVDIDGNRLRELQDKyDLQGVTGHSAHPDVLRRAGAEDADMIIAVTSSDEVNM 80
Cdd:COG0569   96 MHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEE-DVLVIVGDATDEEVLEEAGIEDADAVIAATGDDEANI 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736  81 VACQVAYSIfNTPTKIARIRSEQYLKYREKlfhnddLPVDHYIAPEALVTKYIRRLIDYPGALQVLQFADGMLSLVAVKA 160
Cdd:COG0569  175 LACLLAKEL-GVPRIIARANDPEYADLLER------LGADVVISPERLAARRIARLLLRPGVLDVLELADGDAEIVEVTV 247

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 966689736 161 YYGGLLVGYALSALKEHiPNVETRVAAIYRQGKAIKPLGTTVIEADDEVF 210
Cdd:COG0569  248 PEGSPLVGKTLKELDLR-ERYGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 3-111 1.40e-23

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 94.90  E-value: 1.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736    3 IIILGAGQVGGTLAENLVgEQNEITVVDIDGNRLRELQDKYdLQGVTGHSAHPDVLRRAGAEDADMIIAVTSSDEVNMVA 82
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELS-EGGDVVVIDKDEERVEELREEG-VPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILI 78

                          90       100
                  ....*....|....*....|....*....
gi 966689736   83 CQVAYSIFNTPTKIARIRSEQYLKYREKL 111
Cdd:pfam02254  79 VLLARELNPDKKIIARANDPEHAELLRRL 107
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 247-350 3.57e-19

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 82.57  E-value: 3.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736  247 LARSLEKNHSVKLLERNKERAAQLSEmlDNTVVFCGDASDQELLSEEHIEQVDVFIAVTNDDEANIMSAMLAKRM-GAQK 325
Cdd:pfam02254  13 LAEELSEGGDVVVIDKDEERVEELRE--EGVPVVVGDATDEEVLEEAGIEEADAVIAATGDDEANILIVLLARELnPDKK 90

                          90       100
                  ....*....|....*....|....*
gi 966689736  326 TMVLIQRGAYVDLVQGGEIDIAISP 350
Cdd:pfam02254  91 IIARANDPEHAELLRRLGADHVISP 115
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
 392-452 1.05e-10

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 63.59  E-value: 1.05e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966689736 392 SKVVGRAIADIKLPAGTTIGAIVRNDDVLIAHDDTVIQSGDHViMFLIDKKHITVVEKLFQ 452
Cdd:COG3263  424 SPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQL-LVLAPPEDLEALERLFA 483
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
3-103 1.23e-09

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 58.97  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736   3 IIILGAGQVGGTLAENLVGEQNEITVVDIDGNRLRELQdKYDLQGVTGHSAHPDVLRRAGAEDADMIIAVTSSDEVNMVA 82
Cdd:COG1226  127 VIIAGFGRVGQIVARLLRAEGIPFVVIDLDPERVEELR-RFGIKVYYGDATRPDVLEAAGIERARALVVAIDDPEAALRI 205

                         90       100
                 ....*....|....*....|.
gi 966689736  83 CQVAYSIFNTPTKIARIRSEQ 103
Cdd:COG1226  206 VELARELNPDLKIIARARDRE 226
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 391-451 5.50e-09

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 52.61  E-value: 5.50e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966689736  391 TSKVVGRAIADIKLPA--GTTIGAIVRNDDVLIAHDDTVIQSGDHVImFLIDKKHITVVEKLF 451
Cdd:pfam02080   9 NSPLVGKTLKELNLPErfGVRIVAIRRGGRLIIPSGDTVLEAGDRLL-VIGTPDDLAALRELL 70
PRK05326 PRK05326
potassium/proton antiporter;
392-452 4.89e-08

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 55.21  E-value: 4.89e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966689736 392 SKVVGRAIADIKLPAGTTIGAIVRNDDVLIAHDDTVIQSGDHVIMfLIDKKHITVVEKLFQ 452
Cdd:PRK05326 425 SWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLV-LGPERDLPALERLFS 484
L-AlaDH cd05305
Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) ...
 2-72 1.66e-06

Alanine dehydrogenase NAD-binding and catalytic domains; Alanine dehydrogenase (L-AlaDH) catalyzes the NAD-dependent conversion of pyruvate to L-alanine via reductive amination. Like formate dehydrogenase and related enzymes, L-AlaDH is comprised of 2 domains connected by a long alpha helical stretch, each resembling a Rossmann fold NAD-binding domain. The NAD-binding domain is inserted within the linear sequence of the more divergent catalytic domain. Ligand binding and active site residues are found in the cleft between the subdomains. L-AlaDH is typically hexameric and is critical in carbon and nitrogen metabolism in micro-organisms.


Pssm-ID: 240630 [Multi-domain]  Cd Length: 359  Bit Score: 50.10  E-value: 1.66e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966689736   2 KIIILGAGQVGGTLAENLVGEQNEITVVDIDGNRLRELQDKYDlQGVTGHSAHPDVLRRAgAEDADMII-AV 72
Cdd:cd05305  170 KVVILGAGVVGENAARVALGLGAEVTVLDINLERLRYLDDIFG-GRVTTLYSNPANLEEA-LKEADLVIgAV 239
Ald COG0686
Alanine dehydrogenase (includes sporulation protein SpoVN) [Amino acid transport and ...
 2-72 2.46e-06

Alanine dehydrogenase (includes sporulation protein SpoVN) [Amino acid transport and metabolism]; Alanine dehydrogenase (includes sporulation protein SpoVN) is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440450 [Multi-domain]  Cd Length: 372  Bit Score: 49.24  E-value: 2.46e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966689736   2 KIIILGAGQVGGTLAENLVGEQNEITVVDIDGNRLRELQDKYDlQGVTGHSAHPDVLRRAgAEDADMII-AV 72
Cdd:COG0686  170 KVVILGGGVVGTNAARMALGLGADVTVLDINLDRLRRLDDIFG-GRVTTLYSNPANIEEA-LKEADLVIgAV 239
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 360-451 3.83e-06

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 49.35  E-value: 3.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736 360 THVRRGDIVNVYSLRKGAAEAIEAVAHGDEHTS----------------KVVGRAIADIKLPA--GTTIGAIVRNDDVLI 421
Cdd:COG2985  248 TVLQEGDIVLVVGTREALEAAEALLGEEVDDSElldsdldvrrivvtnkEVAGKTLGELNLRNrfGVVITRVRRGGVELP 327

                         90       100       110
                 ....*....|....*....|....*....|
gi 966689736 422 AHDDTVIQSGDhVIMFLIDKKHITVVEKLF 451
Cdd:COG2985  328 ATPDTVLQLGD-RLTVVGPKEDVERVAKLL 356
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 155-225 8.53e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 43.37  E-value: 8.53e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966689736  155 LVAVKAYYGGLLVGYALSALK-EHIPNVetRVAAIYRQGKAIKPLGTTVIEADDEVFFIAATKHIRAVMNEL 225
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNlPERFGV--RIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
PRK05326 PRK05326
potassium/proton antiporter;
165-221 2.42e-04

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 43.65  E-value: 2.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966689736 165 LLVGYALSALkeHIPNvETRVAAIYRQGKAIKPLGTTVIEADDEVFFIAATKHIRAV 221
Cdd:PRK05326 426 WLVGKALRDL--RLPR-GALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPAL 479
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 1-72 9.44e-04

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 40.82  E-value: 9.44e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966689736   1 MKIIILGAGQVGGTLAENLVG---EQNEITVVDIDGNRLRELQDKYdlqGVTGHSAHPDVlrragAEDADMII-AV 72
Cdd:COG0345    3 MKIGFIGAGNMGSAIIKGLLKsgvPPEDIIVSDRSPERLEALAERY---GVRVTTDNAEA-----AAQADVVVlAV 70
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 377-434 1.34e-03

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 40.88  E-value: 1.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966689736 377 AAEAIEAVAHGDEHTSKVVGRA------------IADIK--LPAGTTIGAIVRNDDVLIAHDDTVIQSGDHV 434
Cdd:COG2985  185 DAEAKKLEAGEGSAYPPLVTRAyrvtnpnlvgktVAELEalLGTRVVISRIRRGGEIIVPTPDTVLQEGDIV 256
NmrA pfam05368
NmrA-like family; NmrA is a negative transcriptional regulator involved in the ...
 250-324 1.46e-03

NmrA-like family; NmrA is a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi. This family only contains a few sequences as iteration results in significant matches to other Rossmann fold families.


Pssm-ID: 398829 [Multi-domain]  Cd Length: 236  Bit Score: 40.02  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736  250 SLEKNHSVKLLERN--KERAAQLSEmLDNTVVfCGDASDQELLsEEHIEQVDVFIAVTN-------DDEANIMSAmlAKR 320
Cdd:pfam05368  18 SLKAGHKVRALVRDpkSELAKSLKE-AGVELV-KGDLDDKESL-VEALKGVDVVFSVTGfwagkeiEDGKKLADA--AKE 92


                  ....
gi 966689736  321 MGAQ 324
Cdd:pfam05368  93 AGVK 96
WcaG COG0451
Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis];
2-70 2.13e-03

Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440220 [Multi-domain]  Cd Length: 295  Bit Score: 39.96  E-value: 2.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966689736   2 KIIILGA-GQVGGTLAENLVGEQNEITVVDIDGNRLRELQDKYDLQGVTGHSAHPDVLRRAgAEDADMII 70
Cdd:COG0451    1 RILVTGGaGFIGSHLARRLLARGHEVVGLDRSPPGAANLAALPGVEFVRGDLRDPEALAAA-LAGVDAVV 69
NAD_bind_Leu_Phe_Val_DH cd01075
NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine ...
 1-44 9.00e-03

NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Amino acid dehydrogenase (DH) is a widely distributed family of enzymes that catalyzes the oxidative deamination of an amino acid to its keto acid and ammonia with concomitant reduction of NADP+. For example, leucine DH catalyzes the reversible oxidative deamination of L-leucine and several other straight or branched chain amino acids to the corresponding 2-oxoacid derivative. Amino acid DH -like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.


Pssm-ID: 133444  Cd Length: 200  Bit Score: 37.57  E-value: 9.00e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 966689736   1 MKIIILGAGQVGGTLAENLVGEQNEITVVDIDGNRLRELQDKYD 44
Cdd:cd01075   29 KTVAVQGLGKVGYKLAEHLLEEGAKLIVADINEEAVARAAELFG 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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