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Conserved domains on  [gi|966689735|gb|KTG22567|]
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calmodulin [Pseudoalteromonas sp. XI10]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000101)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
26-70 8.92e-10

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 50.95  E-value: 8.92e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966689735  26 FSTFDTDGDGVISKEEASANM--------QLEKLFPELDSDGNGELSKEEFAQ 70
Cdd:COG5126   75 FDLLDTDGDGKISADEFRRLLtalgvseeEADELFARLDTDGDGKISFEEFVA 127
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
26-70 8.92e-10

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 50.95  E-value: 8.92e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966689735  26 FSTFDTDGDGVISKEEASANM--------QLEKLFPELDSDGNGELSKEEFAQ 70
Cdd:COG5126   75 FDLLDTDGDGKISADEFRRLLtalgvseeEADELFARLDTDGDGKISFEEFVA 127
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 26-71 7.27e-09

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 46.77  E-value: 7.27e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689735 26 FSTFDTDGDGVISKEEASANMQ----------LEKLFPELDSDGNGELSKEEFAQI 71
Cdd:cd00051   6 FRLFDKDGDGTISADELKAALKslgeglseeeIDEMIREVDKDGDGKIDFEEFLEL 61
EF-hand_7 pfam13499
EF-hand domain pair;
26-71 5.09e-06

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 39.54  E-value: 5.09e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966689735  26 FSTFDTDGDGVISKEE------------ASANMQLEKLFPELDSDGNGELSKEEFAQI 71
Cdd:pfam13499  8 FKLLDSDGDGYLDVEElkkllrkleegePLSDEEVEELFKEFDLDKDGRISFEEFLEL 65
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
6-70 1.31e-05

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 40.43  E-value: 1.31e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966689735   6 TTIAILALATSSAAFAQGVSFSTFDTDGDGVISKEEASANM----------QLEKLFPELDSDGNGELSKEEFAQ 70
Cdd:NF041410  13 TSTSSSSTSSARSQQFQKQLFAKLDSDGDGSVSQDELSSALssksddgsliDLSELFSDLDSDGDGSLSSDELAA 87
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
26-70 3.53e-05

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 39.28  E-value: 3.53e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966689735  26 FSTFDTDGDGVISKEEASANMQ-------LEKLFPELDSDGNGELSKEEFAQ 70
Cdd:NF041410 109 LSALDTDGDGSISSDELSAGLTsagssadSSQLFSALDSDGDGSVSSDELAA 160
PTZ00183 PTZ00183
centrin; Provisional
 26-71 5.39e-04

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 35.82  E-value: 5.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689735  26 FSTFDTDGDGVISKEEASANMQ----------LEKLFPELDSDGNGELSKEEFAQI 71
Cdd:PTZ00183  23 FDLFDTDGSGTIDPKELKVAMRslgfepkkeeIKQMIADVDKDGSGKIDFEEFLDI 78
EH smart00027
Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe ...
 26-69 8.35e-04

Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.


Pssm-ID: 197477 [Multi-domain]  Cd Length: 96  Bit Score: 34.56  E-value: 8.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966689735   26 FSTFDTDGDGVISKEEASA--------NMQLEKLFPELDSDGNGELSKEEFA 69
Cdd:smart00027 16 FRSLDKNQDGTVTGAQAKPillksglpQTLLAKIWNLADIDNDGELDKDEFA 67
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
26-69 7.69e-03

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 32.73  E-value: 7.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966689735  26 FSTFDTDGDGVISKEEASANMQL--------------EKLFPELDSDGNGELSKEEFA 69
Cdd:NF041410  69 FSDLDSDGDGSLSSDELAAAAPPpppppdqapstelaDDLLSALDTDGDGSISSDELS 126
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
26-70 8.92e-10

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 50.95  E-value: 8.92e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966689735  26 FSTFDTDGDGVISKEEASANM--------QLEKLFPELDSDGNGELSKEEFAQ 70
Cdd:COG5126   75 FDLLDTDGDGKISADEFRRLLtalgvseeEADELFARLDTDGDGKISFEEFVA 127
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 26-71 7.27e-09

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 46.77  E-value: 7.27e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689735 26 FSTFDTDGDGVISKEEASANMQ----------LEKLFPELDSDGNGELSKEEFAQI 71
Cdd:cd00051   6 FRLFDKDGDGTISADELKAALKslgeglseeeIDEMIREVDKDGDGKIDFEEFLEL 61
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
26-70 7.97e-08

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 45.55  E-value: 7.97e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 966689735  26 FSTFDTDGDGVISKEEASANM--QLEKLFPELDSDGNGELSKEEFAQ 70
Cdd:COG5126   11 FDLLDADGDGVLERDDFEALFrrLWATLFSEADTDGDGRISREEFVA 57
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
26-70 2.42e-06

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 41.70  E-value: 2.42e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966689735  26 FSTFDTDGDGVISKEEASANM----------QLEKLFPELDSDGNGELSKEEFAQ 70
Cdd:COG5126   39 FSEADTDGDGRISREEFVAGMeslfeatvepFARAAFDLLDTDGDGKISADEFRR 93
EF-hand_7 pfam13499
EF-hand domain pair;
26-71 5.09e-06

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 39.54  E-value: 5.09e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966689735  26 FSTFDTDGDGVISKEE------------ASANMQLEKLFPELDSDGNGELSKEEFAQI 71
Cdd:pfam13499  8 FKLLDSDGDGYLDVEElkkllrkleegePLSDEEVEELFKEFDLDKDGRISFEEFLEL 65
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
6-70 1.31e-05

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 40.43  E-value: 1.31e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966689735   6 TTIAILALATSSAAFAQGVSFSTFDTDGDGVISKEEASANM----------QLEKLFPELDSDGNGELSKEEFAQ 70
Cdd:NF041410  13 TSTSSSSTSSARSQQFQKQLFAKLDSDGDGSVSQDELSSALssksddgsliDLSELFSDLDSDGDGSLSSDELAA 87
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
26-70 3.53e-05

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 39.28  E-value: 3.53e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966689735  26 FSTFDTDGDGVISKEEASANMQ-------LEKLFPELDSDGNGELSKEEFAQ 70
Cdd:NF041410 109 LSALDTDGDGSISSDELSAGLTsagssadSSQLFSALDSDGDGSVSSDELAA 160
EH cd00052
Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and ...
 26-69 3.68e-05

Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A hydrophobic binding pocket is formed by residues from both EF-hand motifs. The EH domain binds to proteins containing NPF (class I), [WF]W or SWG (class II), or H[TS]F (class III) sequence motifs.


Pssm-ID: 238009 [Multi-domain]  Cd Length: 67  Bit Score: 37.20  E-value: 3.68e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 966689735 26 FSTFDTDGDGVISKEEASANM--------QLEKLFPELDSDGNGELSKEEFA 69
Cdd:cd00052   5 FRSLDPDGDGLISGDEARPFLgksglprsVLAQIWDLADTDKDGKLDKEEFA 56
EFh_CREC_cab45 cd16225
EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also ...
 26-68 4.01e-04

EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also termed stromal cell-derived factor 4 (SDF-4), is a soluble, lumenal Golgi resident low-affinity Ca2+-binding protein that contains six copies of the EF-hand Ca2+-binding motif. It is required for secretory pathway calcium ATPase1 (SPCA1)-dependent Ca2+ import into the trans-Golgi network (TGN) and plays an essential role in Ca2+-dependent secretory cargo sorting at the TGN.


Pssm-ID: 320023 [Multi-domain]  Cd Length: 278  Bit Score: 36.51  E-value: 4.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689735  26 FSTFDTDGDGVISKEEAS-------------ANMQLEKLFPELDSDGNGELSKEEF 68
Cdd:cd16225   40 FKKVDVNTDGFLSAEELEdwimektqehfqeAVEENEQIFKAVDTDKDGNVSWEEY 95
PTZ00183 PTZ00183
centrin; Provisional
 26-71 5.39e-04

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 35.82  E-value: 5.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689735  26 FSTFDTDGDGVISKEEASANMQ----------LEKLFPELDSDGNGELSKEEFAQI 71
Cdd:PTZ00183  23 FDLFDTDGSGTIDPKELKVAMRslgfepkkeeIKQMIADVDKDGSGKIDFEEFLDI 78
EH smart00027
Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe ...
 26-69 8.35e-04

Eps15 homology domain; Pair of EF hand motifs that recognise proteins containing Asn-Pro-Phe (NPF) sequences.


Pssm-ID: 197477 [Multi-domain]  Cd Length: 96  Bit Score: 34.56  E-value: 8.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966689735   26 FSTFDTDGDGVISKEEASA--------NMQLEKLFPELDSDGNGELSKEEFA 69
Cdd:smart00027 16 FRSLDKNQDGTVTGAQAKPillksglpQTLLAKIWNLADIDNDGELDKDEFA 67
EFh_CREC_RCN2_like cd16227
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2) mainly from protostomes; This ...
 29-67 8.64e-04

EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2) mainly from protostomes; This family corresponds to a group of uncharacterized RCN2-like proteins, which are mainly found in protostomes. Although their biological function remains unclear, they show high sequence similarity with RCN2 (also known as E6BP or TCBP-49), which is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. Members in this family contain six copies of the EF-hand Ca2+-binding motif, but may lack a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).


Pssm-ID: 320025 [Multi-domain]  Cd Length: 263  Bit Score: 35.37  E-value: 8.64e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 966689735  29 FDTDGDGVISKEE----------ASANMQLEKLFPELDSDGNGELSKEE 67
Cdd:cd16227  205 YDKDGDGKLDGEEilswlvpdneEIAEEEVDHLFASADDDHDDRLSFDE 253
PTZ00184 PTZ00184
calmodulin; Provisional
 25-68 2.29e-03

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 33.97  E-value: 2.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 966689735  25 SFSTFDTDGDGVISKEEASANM----------QLEKLFPELDSDGNGELSKEEF 68
Cdd:PTZ00184  16 AFSLFDKDGDGTITTKELGTVMrslgqnpteaELQDMINEVDADGNGTIDFPEF 69
PTZ00183 PTZ00183
centrin; Provisional
 26-71 2.51e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 33.89  E-value: 2.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689735  26 FSTFDTDGDGVIS--------KE--EASANMQLEKLFPELDSDGNGELSKEEFAQI 71
Cdd:PTZ00183  96 FRLFDDDKTGKISlknlkrvaKElgETITDEELQEMIDEADRNGDGEISEEEFYRI 151
PTZ00184 PTZ00184
calmodulin; Provisional
 25-71 4.09e-03

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 33.20  E-value: 4.09e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 966689735  25 SFSTFDTDGDGVISKEEASANM----------QLEKLFPELDSDGNGELSKEEFAQI 71
Cdd:PTZ00184  89 AFKVFDRDGNGFISAAELRHVMtnlgekltdeEVDEMIREADVDGDGQINYEEFVKM 145
EF-hand_5 pfam13202
EF hand;
26-41 5.06e-03

EF hand;


Pssm-ID: 433035 [Multi-domain]  Cd Length: 25  Bit Score: 31.14  E-value: 5.06e-03
                         10
                 ....*....|....*.
gi 966689735  26 FSTFDTDGDGVISKEE 41
Cdd:pfam13202  5 FRQIDLNGDGKISKEE 20
EFh_SPARC_EC cd00252
EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich ...
 26-69 5.41e-03

EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins; The SPARC protein family represents a diverse group of proteins that share a follistatin-like (FS) domain and an extracellular calcium-binding (EC) domain with two EF-hand motifs. It includes SPARC (for secreted protein acidic and rich in cysteine, also termed osteonectin/ON, or basement-membrane protein 40/BM-40), SPARC-like protein 1 (for secreted protein, acidic and rich in cysteines-like 1/ SPARCL1, also termed high endothelial venule protein/Hevi, or MAST 9, or SC-1, or RAGS-1, or QR1, or ECM 2), testicans 1, 2, and 3 (also termed SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycans, or SPOCK), secreted modular calcium-binding protein SMOC-1 (also termed SPARC-related modular calcium-binding protein 1) and SMOC-2 (also termed SPARC-related modular calcium-binding protein 2, or smooth muscle-associated protein 2/SMAP-2), follistatin-related protein 1 (FRP-1, also termed follistatin-like protein 1/fstl-1, TSC-36/Flik, TGF-beta inducible protein). The SPARC proteins have been implicated in modulating cell interaction with the extracellular milieu, including regulation of extracellular matrix assembly and deposition, counter-adhesion, effects on extracellular protease activity, and modulation of growth factor/cytokine signaling pathways, as well as in development and disease.


Pssm-ID: 320009  Cd Length: 107  Bit Score: 32.73  E-value: 5.41e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966689735  26 FSTFDTDGDGVISKEE----ASANMQLEK----LFPELDSDGNGELSKEEFA 69
Cdd:cd00252   51 FDNLDNNKDGKLDKRElapfRAPLMPLEHcargFFESCDLNKDKKISLQEWL 102
EFh_SPARC_SMOC cd16234
EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding ...
 25-69 5.55e-03

EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein SMOC-1, SMOC-2, and similar proteins; SMOC proteins corresponds to a group matricellular proteins that are involved in direct or indirect modulation of growth factor signaling pathways and play diverse roles in physiological processes involving extensive tissue remodeling, migration, proliferation, and angiogenesis. They may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development. SMOC-1 is localized in basement membranes. Its mutations have been found to be associated with individuals with Warrdenburg Anopthalmia Syndrome. SMOC-2 is ubiquitously expressed and is involved in angiogenesis and the regulation of cell cycle progression. It enhances the angiogenic effect of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). It has also been implicated in generalized vitiligo. SMOC proteins consist of a follistatin-like (FS) domain, two thyroglobulin-like (TY) domains, a novel domain conserved only in SMOC proteins, and an extracellular calcium-binding (EC) domain with two EF-hand calcium-binding motifs.


Pssm-ID: 320013  Cd Length: 104  Bit Score: 32.64  E-value: 5.55e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 966689735  25 SFSTFDTDGDGVISKEE-------ASANMQLEKL---FPEL-DSDGNGELSKEEFA 69
Cdd:cd16234   44 KFSQLDKNKNGVLERKEwkpfkrlLKKAVKPKKCarkFPKYcDVNKDKKISLTEWL 99
EFh_PI-PLCdelta cd16202
EF-hand motif found in phosphoinositide phospholipase C delta (PI-PLC-delta); PI-PLC-delta ...
 26-70 5.77e-03

EF-hand motif found in phosphoinositide phospholipase C delta (PI-PLC-delta); PI-PLC-delta isozymes represent a class of metazoan PI-PLCs that are some of the most sensitive to calcium among all PLCs. Their activation is modulated by intracellular calcium ion concentration, phospholipids, polyamines, and other proteins, such as RhoAGAP. Like other PI-PLC isozymes, PI-PLC-delta isozymes contain a core set of domains, including an N-terminal pleckstrin homology (PH) domain, four atypical EF-hand motifs, a PLC catalytic core, and a single C-terminal C2 domain. The PLC catalytic core domain is a TIM barrel with two highly conserved regions (X and Y) split by a highly degenerate linker sequence. There are three PI-PLC-delta isozymes (1, 3 and 4). PI-PLC-delta1 is relatively well characterized. It is activated by high calcium levels generated by other PI-PLC family members, and therefore functions as a calcium amplifier within the cell. Different PI-PLC-delta isozymes have different tissue distribution and different subcellular locations. PI-PLC-delta1 is mostly a cytoplasmic protein, PI-PLC-delta3 is located in the membrane, and PI-PLC-delta4 is predominantly detected in the cell nucleus. PI-PLC-delta isozymes is evolutionarily conserved even in non-mammalian species, such as yeast, slime molds and plants.


Pssm-ID: 320032 [Multi-domain]  Cd Length: 140  Bit Score: 32.97  E-value: 5.77e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966689735  26 FSTFDTDGDGVISKEEASA-----NMQLEK-----LFPELDSDGNGELSKEEFAQ 70
Cdd:cd16202    6 FRKADKNGDGKLSFKECKKllkklNVKVDKdyakkLFQEADTSGEDVLDEEEFVQ 60
EFh_CREC_RCN2 cd16224
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed ...
 30-68 6.64e-03

EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed calcium-binding protein ERC-55, or E6-binding protein (E6BP), or TCBP-49, is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. It is associated with tumorigenesis, in particular with transformation of cells of the cervix induced by human papillomavirus (HPV), through binding to human papillomavirus (HPV) E6 oncogenic protein. It specifically interacts with vitamin D receptor among nuclear receptors. RCN2 contains an N-terminal signal sequence followed by six copies of the EF-hand Ca2+-binding motif, and a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).


Pssm-ID: 320022 [Multi-domain]  Cd Length: 268  Bit Score: 33.17  E-value: 6.64e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 966689735  30 DTDGDGVISKEEASANMQL----------EKLFPELDSDGNGELSKEEF 68
Cdd:cd16224   46 DTDSDGFLTEEELSSWIQQsfrhyaledaKQQFPEYDKDGDGAVTWDEY 94
XopAW NF041410
XopAW family type III secretion system calcium-binding effector;
26-69 7.69e-03

XopAW family type III secretion system calcium-binding effector;


Pssm-ID: 469301 [Multi-domain]  Cd Length: 227  Bit Score: 32.73  E-value: 7.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966689735  26 FSTFDTDGDGVISKEEASANMQL--------------EKLFPELDSDGNGELSKEEFA 69
Cdd:NF041410  69 FSDLDSDGDGSLSSDELAAAAPPpppppdqapstelaDDLLSALDTDGDGSISSDELS 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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