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Conserved domains on  [gi|9629505|ref|NP_056913|]
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hypothetical protein STLV2gp10 [Simian T-lymphotropic virus 2]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Deltaretro_Tax super family cl05262
Deltaretrovirus Tax protein; This family consists of Rex/Tax proteins from human and simian ...
 1-87 5.68e-40

Deltaretrovirus Tax protein; This family consists of Rex/Tax proteins from human and simian T-cell leukaemia viruses. The exact function of these proteins is unknown. Tax is the viral transactivator; is it a nuclear phosphoprotein that interacts with CREB, coactivator CBP/p300 and PCAF to form a multiprotein complex, which activates viral LTR and stimulates virus expression. Tax is also involved in deregulated expression of numerous cellular genes leading to T-cell leukaemia. Rex is a nucleolar post transcriptional regulator that facilitates export to the cytoplasm of viral RNA not or incompletely spliced [personal communication, Dr. S Nicot].


The actual alignment was detected with superfamily member pfam05599:

Pssm-ID: 191311  Cd Length: 87  Bit Score: 128.16  E-value: 5.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9629505      1 MPFFSPLSRFRTEPPLWIPSLRVWRLCSSRLVSRFRWALFHPPAPACPSRHLPGAPAHLGPHRWTRCRLSSPIPYPSAPL 80
Cdd:pfam05599   1 MLFFSPLPRFRTEPPFRIPSLRVWRLCSRRLVPHFRGALFGPPAPACPSGHLPGAPAHLGPHRWTRCRLSSPIPYPSAPL 80


                  ....*..
gi 9629505     81 LPHPENL 87
Cdd:pfam05599  81 LPHPENL 87
 
Name Accession Description Interval E-value
Deltaretro_Tax pfam05599
Deltaretrovirus Tax protein; This family consists of Rex/Tax proteins from human and simian ...
 1-87 5.68e-40

Deltaretrovirus Tax protein; This family consists of Rex/Tax proteins from human and simian T-cell leukaemia viruses. The exact function of these proteins is unknown. Tax is the viral transactivator; is it a nuclear phosphoprotein that interacts with CREB, coactivator CBP/p300 and PCAF to form a multiprotein complex, which activates viral LTR and stimulates virus expression. Tax is also involved in deregulated expression of numerous cellular genes leading to T-cell leukaemia. Rex is a nucleolar post transcriptional regulator that facilitates export to the cytoplasm of viral RNA not or incompletely spliced [personal communication, Dr. S Nicot].


Pssm-ID: 191311  Cd Length: 87  Bit Score: 128.16  E-value: 5.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9629505      1 MPFFSPLSRFRTEPPLWIPSLRVWRLCSSRLVSRFRWALFHPPAPACPSRHLPGAPAHLGPHRWTRCRLSSPIPYPSAPL 80
Cdd:pfam05599   1 MLFFSPLPRFRTEPPFRIPSLRVWRLCSRRLVPHFRGALFGPPAPACPSGHLPGAPAHLGPHRWTRCRLSSPIPYPSAPL 80


                  ....*..
gi 9629505     81 LPHPENL 87
Cdd:pfam05599  81 LPHPENL 87
 
Name Accession Description Interval E-value
Deltaretro_Tax pfam05599
Deltaretrovirus Tax protein; This family consists of Rex/Tax proteins from human and simian ...
 1-87 5.68e-40

Deltaretrovirus Tax protein; This family consists of Rex/Tax proteins from human and simian T-cell leukaemia viruses. The exact function of these proteins is unknown. Tax is the viral transactivator; is it a nuclear phosphoprotein that interacts with CREB, coactivator CBP/p300 and PCAF to form a multiprotein complex, which activates viral LTR and stimulates virus expression. Tax is also involved in deregulated expression of numerous cellular genes leading to T-cell leukaemia. Rex is a nucleolar post transcriptional regulator that facilitates export to the cytoplasm of viral RNA not or incompletely spliced [personal communication, Dr. S Nicot].


Pssm-ID: 191311  Cd Length: 87  Bit Score: 128.16  E-value: 5.68e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9629505      1 MPFFSPLSRFRTEPPLWIPSLRVWRLCSSRLVSRFRWALFHPPAPACPSRHLPGAPAHLGPHRWTRCRLSSPIPYPSAPL 80
Cdd:pfam05599   1 MLFFSPLPRFRTEPPFRIPSLRVWRLCSRRLVPHFRGALFGPPAPACPSGHLPGAPAHLGPHRWTRCRLSSPIPYPSAPL 80


                  ....*..
gi 9629505     81 LPHPENL 87
Cdd:pfam05599  81 LPHPENL 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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