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Conserved domains on  [gi|962015140|ref|XP_014832310|]
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PREDICTED: heparan sulfate glucosamine 3-O-sulfotransferase 6-like [Poecilia mexicana]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
97-333 4.35e-43

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 149.42  E-value: 4.35e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140   97 PQAIIIGVKKGGTRALLEFLRVHPDVRAVGA--EPHFFDRC-YDKGLGWY-RSLMPRTLEGQITMEKTPSYFITK----E 168
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNHnRSPFLEWYpGDTYFDVAEGPVRLNALPSPRIIKthlpL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140  169 APRRVHALSRHTKLIVVVRDPVTRAISDYTQT----LSKSPGLPSFQNLAFrndsatlidtSWSAVRIGIYAKHLENWLR 244
Cdd:pfam00685  82 HLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNGKVNCGSYFDHVKGWWK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140  245 YFPLSRFLFVSGERLVTDPAGEMGRVQDFLGLKR---VVTD--KHFYFNQTKGFPCLKKPE-----GSSRPRCLGKSKgr 314
Cdd:pfam00685 152 LRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeELDKivKHLSFENMKGNPCLNYSKlpkevSPFFRKGLVGDW-- 229

                         250
                  ....*....|....*....
gi 962015140  315 pHPQIPTEVLLRLRDFYRP 333
Cdd:pfam00685 230 -KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
97-333 4.35e-43

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 149.42  E-value: 4.35e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140   97 PQAIIIGVKKGGTRALLEFLRVHPDVRAVGA--EPHFFDRC-YDKGLGWY-RSLMPRTLEGQITMEKTPSYFITK----E 168
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNHnRSPFLEWYpGDTYFDVAEGPVRLNALPSPRIIKthlpL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140  169 APRRVHALSRHTKLIVVVRDPVTRAISDYTQT----LSKSPGLPSFQNLAFrndsatlidtSWSAVRIGIYAKHLENWLR 244
Cdd:pfam00685  82 HLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNGKVNCGSYFDHVKGWWK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140  245 YFPLSRFLFVSGERLVTDPAGEMGRVQDFLGLKR---VVTD--KHFYFNQTKGFPCLKKPE-----GSSRPRCLGKSKgr 314
Cdd:pfam00685 152 LRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeELDKivKHLSFENMKGNPCLNYSKlpkevSPFFRKGLVGDW-- 229

                         250
                  ....*....|....*....
gi 962015140  315 pHPQIPTEVLLRLRDFYRP 333
Cdd:pfam00685 230 -KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
97-333 4.35e-43

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 149.42  E-value: 4.35e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140   97 PQAIIIGVKKGGTRALLEFLRVHPDVRAVGA--EPHFFDRC-YDKGLGWY-RSLMPRTLEGQITMEKTPSYFITK----E 168
Cdd:pfam00685   2 DDVLIVTYPKSGTTWLQEILSLIPNRGDFEKseEPHLFNNHnRSPFLEWYpGDTYFDVAEGPVRLNALPSPRIIKthlpL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140  169 APRRVHALSRHTKLIVVVRDPVTRAISDYTQT----LSKSPGLPSFQNLAFrndsatlidtSWSAVRIGIYAKHLENWLR 244
Cdd:pfam00685  82 HLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFrmakLLKAPGTPFEFVEDF----------LNGKVNCGSYFDHVKGWWK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140  245 YFPLSRFLFVSGERLVTDPAGEMGRVQDFLGLKR---VVTD--KHFYFNQTKGFPCLKKPE-----GSSRPRCLGKSKgr 314
Cdd:pfam00685 152 LRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLteeELDKivKHLSFENMKGNPCLNYSKlpkevSPFFRKGLVGDW-- 229

                         250
                  ....*....|....*....
gi 962015140  315 pHPQIPTEVLLRLRDFYRP 333
Cdd:pfam00685 230 -KNYFTPEQAEKFDEIYQE 247
Sulfotransfer_3 pfam13469
Sulfotransferase family;
100-276 1.04e-18

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 82.34  E-value: 1.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140  100 IIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRCYDKGLGW---YRSLMPRTLEGQITMEKTPSYFitkeapRRVHAL 176
Cdd:pfam13469   2 FIVGLPRSGTTLLHRLLAAHPDVRPPEETWFVIPRILALLQAWgksLEALARVPSYARWLCDKSPSHL------FHLDLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 962015140  177 SR---HTKLIVVVRDPVTRAISDYTQtlskspgLPSFQNLAFRNDSATLIDTSWSAVRIGIYakHLENWLRYFPLSRFLF 253
Cdd:pfam13469  76 LKafpDAKFIHLHRDPVDTVISSYCS-------LFGFTLSSYSTAFLRDIGLALARWSRAYE--RLMAARARVPPGRFLD 146

                         170       180
                  ....*....|....*....|...
gi 962015140  254 VSGERLVTDPAGEMGRVQDFLGL 276
Cdd:pfam13469 147 VRYEDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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