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Conserved domains on  [gi|961754070|ref|XP_014937673|]
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natural cytotoxicity triggering receptor 3 isoform X1 [Acinonyx jubatus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 19-129 2.33e-75

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20926:

Pssm-ID: 472250  Cd Length: 112  Bit Score: 221.00  E-value: 2.33e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070  19 LWVFQPPEIRTQEGSAALLPCSFNASRGRLAIGSVAWYRDKVAPGKEVRNETPEFRGRLAPLASSRFLCDHQAELHIWDT 98
Cdd:cd20926    2 LWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWDV 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 961754070  99 QDCDTGVYVCRVEVLGLGAGTGNGTLLVIEK 129
Cdd:cd20926   82 RGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 19-129 2.33e-75

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 221.00  E-value: 2.33e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070  19 LWVFQPPEIRTQEGSAALLPCSFNASRGRLAIGSVAWYRDKVAPGKEVRNETPEFRGRLAPLASSRFLCDHQAELHIWDT 98
Cdd:cd20926    2 LWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWDV 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 961754070  99 QDCDTGVYVCRVEVLGLGAGTGNGTLLVIEK 129
Cdd:cd20926   82 RGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-119 3.04e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 46.68  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070   23 QPPEIRTQEGSAALLPCSFNaSRGRLAIGSVAWYRDKVAPGKEV-------RNETPEFRGRLAPLASSRFlcdHQAELHI 95
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYS-SSMSEASTSVYWYRQPPGKGPTFliayysnGSEEGVKKGRFSGRGDPSN---GDGSLTI 77

                          90       100
                  ....*....|....*....|....*..
gi 961754070   96 WDTQDCDTGVYVCRV---EVLGLGAGT 119
Cdd:pfam07686  78 QNLTLSDSGTYTCAVipsGEGVFGKGT 104
IGv smart00406
Immunoglobulin V-Type;
37-108 1.69e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 35.82  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070    37 LPCSFnaSRGRLAIGSVAWYRdkVAPGKEV-----------RNETPEFRGRLAplaSSRFLCDHQAELHIWDTQDCDTGV 105
Cdd:smart00406   4 LSCKF--SGSTFSSYYVSWVR--QPPGKGLewlgyigsngsSYYQESYKGRFT---ISKDTSKNDVSLTISNLRVEDTGT 76


                   ...
gi 961754070   106 YVC 108
Cdd:smart00406  77 YYC 79
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 19-129 2.33e-75

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 221.00  E-value: 2.33e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070  19 LWVFQPPEIRTQEGSAALLPCSFNASRGRLAIGSVAWYRDKVAPGKEVRNETPEFRGRLAPLASSRFLCDHQAELHIWDT 98
Cdd:cd20926    2 LWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWDV 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 961754070  99 QDCDTGVYVCRVEVLGLGAGTGNGTLLVIEK 129
Cdd:cd20926   82 RGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 23-119 3.04e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 46.68  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070   23 QPPEIRTQEGSAALLPCSFNaSRGRLAIGSVAWYRDKVAPGKEV-------RNETPEFRGRLAPLASSRFlcdHQAELHI 95
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYS-SSMSEASTSVYWYRQPPGKGPTFliayysnGSEEGVKKGRFSGRGDPSN---GDGSLTI 77

                          90       100
                  ....*....|....*....|....*..
gi 961754070   96 WDTQDCDTGVYVCRV---EVLGLGAGT 119
Cdd:pfam07686  78 QNLTLSDSGTYTCAVipsGEGVFGKGT 104
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 24-128 1.85e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 39.18  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070  24 PPEIRTQEGSAALLPCSFNASrgrlAIGSVAWYRDKvaPGKE-------VRNETPEFRGRL-APLASSRflcdHQAELHI 95
Cdd:cd04983    5 PQSLSVQEGENVTLNCNYSTS----TFYYLFWYRQY--PGQGpqfliyiSSDSGNKKKGRFsATLDKSR----KSSSLHI 74

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 961754070  96 WDTQDCDTGVYVCrveVLGLGAGT-----GNGTLLVIE 128
Cdd:cd04983   75 SAAQLSDSAVYFC---ALSESGGTgkltfGKGTRLTVE 109
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 20-111 3.92e-04

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 38.52  E-value: 3.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070  20 WVFQPPEIRTQEGSAALLPCSF------NASRGRLAIgsvaWYRDK--------VAPGKEVRNETPEFRGRlaplasSRF 85
Cdd:cd05712    2 GLQMPKSVTVQEGLCVLIPCSFsypadyWVSNPVHGY----WYRGGpypkyrppVATNNRTREVHESTQGR------FRL 71

                         90       100
                 ....*....|....*....|....*....
gi 961754070  86 LCDHQAE---LHIWDTQDCDTGVYVCRVE 111
Cdd:cd05712   72 LGDPGKKncsLSISDARPEDSGKYFFRVE 100
IGv smart00406
Immunoglobulin V-Type;
37-108 1.69e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 35.82  E-value: 1.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070    37 LPCSFnaSRGRLAIGSVAWYRdkVAPGKEV-----------RNETPEFRGRLAplaSSRFLCDHQAELHIWDTQDCDTGV 105
Cdd:smart00406   4 LSCKF--SGSTFSSYYVSWVR--QPPGKGLewlgyigsngsSYYQESYKGRFT---ISKDTSKNDVSLTISNLRVEDTGT 76


                   ...
gi 961754070   106 YVC 108
Cdd:smart00406  77 YYC 79
IgV_1_Nectin-4_like cd05888
First immunoglobulin (Ig) domain of nectin-4, and similar domains; The members here are ...
 31-110 2.17e-03

First immunoglobulin (Ig) domain of nectin-4, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-4 (also known as poliovirus receptor related protein 4 or LNIR receptor). Nectin-4 belongs to the nectin family, which is comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example nectin-4 trans-interacts with nectin-1. Nectin-4 has also been shown to interact with the actin filament-binding protein, afadin. Unlike the other nectins, which are widely expressed in adult tissues, nectin-4 is mainly expressed during embryogenesis, and is not detected in normal adult tissue or in serum. Nectin-4 is re-expressed in breast carcinoma, and patients having metastatic breast cancer have a circulating form of nectin-4 formed from the ectodomain


Pssm-ID: 409471  Cd Length: 108  Bit Score: 36.03  E-value: 2.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070  31 EGSAALLPCSFNASRGrLAIGSVAWYRDKVAPG---------KEVRNETPEFRGRLAPLASSRFLcdhQAELHIWDTQDC 101
Cdd:cd05888    7 LGQDAKLPCFYRGDSG-EQVGQVAWARVDAGEGaqeiallhsKYGLHVFPAYEGRVEQPPPPRPA---DGSVLLRNAVQA 82


                 ....*....
gi 961754070 102 DTGVYVCRV 110
Cdd:cd05888   83 DEGEYECRV 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 24-126 3.56e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.17  E-value: 3.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070    24 PPEIRTQEGSAALLPCSFNASRGrlaiGSVAWYRDKvapgkevrNETPEFRGRLAPLASSrflcdHQAELHIWDTQDCDT 103
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPP----PEVTWYKQG--------GKLLAESGRFSVSRSG-----STSTLTISNVTPEDS 63

                           90       100
                   ....*....|....*....|...
gi 961754070   104 GVYVCRVEVlGLGAGTGNGTLLV 126
Cdd:smart00410  64 GTYTCAATN-SSGSASSGTTLTV 85
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 21-110 5.68e-03

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 35.10  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961754070  21 VFQPPEIRTQEGSAALLPCSFNASRGRLAIGSVAW-YRDkvapgkEVRNETPEF----RGRLAPLASSRF---------L 86
Cdd:cd05715    3 VYTPRELNVLNGSDVRLTCTFTSCYTVGDAFSVTWtYQP------EGGNTTESMfhysKGKPYILKVGRFkdrvswagnP 76

                         90       100
                 ....*....|....*....|....
gi 961754070  87 CDHQAELHIWDTQDCDTGVYVCRV 110
Cdd:cd05715   77 SKKDASIVISNLQFSDNGTYTCDV 100
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 35-111 9.18e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 33.46  E-value: 9.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 961754070  35 ALLPCSFNASRGrlaiGSVAWYRDkvapGKEVRNETPEFRGRLaplassrflcDHQAELHIWDTQDCDTGVYVCRVE 111
Cdd:cd00096    1 VTLTCSASGNPP----PTITWYKN----GKPLPPSSRDSRRSE----------LGNGTLTISNVTLEDSGTYTCVAS 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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