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Conserved domains on  [gi|961462310|gb|ALS32521|]
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endonuclease III [Pseudoalteromonas translucida KMM 520]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10702 super family cl32560
endonuclease III; Provisional
 6-213 1.43e-133

endonuclease III; Provisional


The actual alignment was detected with superfamily member PRK10702:

Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 373.58  E-value: 1.43e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310   6 MNKEKRHQILTRLRDDNPHPETELEYSSPFELLVAVTLSAQATDVGVNKATRKLFPVANTPQAILDLGHDTLRDYIKTIG 85
Cdd:PRK10702   1 MNKAKRLEILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  86 LFNSKAANVYKMCQILVDEHNSIVPENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKLAMGKDVVAVE 165
Cdd:PRK10702  81 LYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 961462310 166 QKLEKVVPKEFKVDVHHWLILHGRYTCVARKPKCGSCIIEDLCEFKDK 213
Cdd:PRK10702 161 EKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEK 208
 
Name Accession Description Interval E-value
PRK10702 PRK10702
endonuclease III; Provisional
 6-213 1.43e-133

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 373.58  E-value: 1.43e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310   6 MNKEKRHQILTRLRDDNPHPETELEYSSPFELLVAVTLSAQATDVGVNKATRKLFPVANTPQAILDLGHDTLRDYIKTIG 85
Cdd:PRK10702   1 MNKAKRLEILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  86 LFNSKAANVYKMCQILVDEHNSIVPENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKLAMGKDVVAVE 165
Cdd:PRK10702  81 LYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 961462310 166 QKLEKVVPKEFKVDVHHWLILHGRYTCVARKPKCGSCIIEDLCEFKDK 213
Cdd:PRK10702 161 EKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEK 208
Nth COG0177
Endonuclease III [Replication, recombination and repair];
15-212 2.70e-119

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 336.68  E-value: 2.70e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  15 LTRLRDDNPHPETELEYSSPFELLVAVTLSAQATDVGVNKATRKLFPVANTPQAILDLGHDTLRDYIKTIGLFNSKAANV 94
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  95 YKMCQILVDEHNSIVPENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKLAMGKDVVAVEQKLEKVVPK 174
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 961462310 175 EFKVDVHHWLILHGRYTCVARKPKCGSCIIEDLCEFKD 212
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLCPYYG 198
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 8-199 3.89e-112

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 318.56  E-value: 3.89e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310    8 KEKRHQILTRLRDDNPHPETELEYSSPFELLVAVTLSAQATDVGVNKATRKLFPVANTPQAILDLGHDTLRDYIKTIGLF 87
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310   88 NSKAANVYKMCQILVDEHNSIVPENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKLAMGKDVVAVEQK 167
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEED 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 961462310  168 LEKVVPKEFKVDVHHWLILHGRYTCVARKPKC 199
Cdd:TIGR01083 161 LMKLVPREFWVKLHHWLILHGRYTCKARKPLC 192
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 35-188 6.43e-49

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 157.02  E-value: 6.43e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  35 FELLVAVTLSAQATDVGVNKATRKLFP-VANTPQAILDLGHDTLRDYIKTIGlFNSKAANVYKMCQILVDEHNSIV---P 110
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFErYGPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961462310 111 ENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKL-AMGKDVVAVEQKLEKVVPKEFKVDVHHWLILHG 188
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLiPKKKTPEELEELLEELLPKPYWGEANQALMDLG 158
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 43-190 5.92e-48

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 154.34  E-value: 5.92e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310    43 LSAQATDVGVNKATRKLFPVANTPQAILDLGHDTLRDYIKTIGLFNSKAANVYKMCQILVDEHNSIVPENREALEALPGV 122
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961462310   123 GRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKLAMGKDV-VAVEQKLEKVVPKEFKVDVHHWLILHGRY 190
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKSTpEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 39-174 7.01e-36

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 123.16  E-value: 7.01e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310   39 VAVTLSAQATDVGVNKATRKLF-PVANTPQAILDLGHDTLRDYIKTIGLFNSKAANVYKMCQILVDEHNSIVPENREALE 117
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFeKFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 961462310  118 A-LPGVGRKTANVVLNTAFG--WPVIAVDTHIFRVSNRTKLAMGKD-VVAVEQKLEKVVPK 174
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrpDPLPVVDTHVRRVLKRLGLIKEKPtPKEVERELEELWPP 141
 
Name Accession Description Interval E-value
PRK10702 PRK10702
endonuclease III; Provisional
 6-213 1.43e-133

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 373.58  E-value: 1.43e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310   6 MNKEKRHQILTRLRDDNPHPETELEYSSPFELLVAVTLSAQATDVGVNKATRKLFPVANTPQAILDLGHDTLRDYIKTIG 85
Cdd:PRK10702   1 MNKAKRLEILTRLRDNNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  86 LFNSKAANVYKMCQILVDEHNSIVPENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKLAMGKDVVAVE 165
Cdd:PRK10702  81 LYNSKAENVIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 961462310 166 QKLEKVVPKEFKVDVHHWLILHGRYTCVARKPKCGSCIIEDLCEFKDK 213
Cdd:PRK10702 161 EKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEK 208
Nth COG0177
Endonuclease III [Replication, recombination and repair];
15-212 2.70e-119

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 336.68  E-value: 2.70e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  15 LTRLRDDNPHPETELEYSSPFELLVAVTLSAQATDVGVNKATRKLFPVANTPQAILDLGHDTLRDYIKTIGLFNSKAANV 94
Cdd:COG0177    1 LERLKELYPDAKTELDYRDPFELLVATILSAQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRNKAKNI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  95 YKMCQILVDEHNSIVPENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKLAMGKDVVAVEQKLEKVVPK 174
Cdd:COG0177   81 IALARILVEKYGGEVPETREELESLPGVGRKTANVVLNFAFGKPAIAVDTHVHRVSNRLGLVPGKDPEEVEKDLMKLIPK 160

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 961462310 175 EFKVDVHHWLILHGRYTCVARKPKCGSCIIEDLCEFKD 212
Cdd:COG0177  161 EYWGDLHHLLILHGRYICKARKPKCEECPLADLCPYYG 198
nth TIGR01083
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ...
 8-199 3.89e-112

endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273434 [Multi-domain]  Cd Length: 192  Bit Score: 318.56  E-value: 3.89e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310    8 KEKRHQILTRLRDDNPHPETELEYSSPFELLVAVTLSAQATDVGVNKATRKLFPVANTPQAILDLGHDTLRDYIKTIGLF 87
Cdd:TIGR01083   1 RQKAQEILERLRKNYPHPTTELDFNNPFELLVATILSAQATDKRVNKATPKLFEVYPTPQALAQAGLEELEEYIKSIGLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310   88 NSKAANVYKMCQILVDEHNSIVPENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKLAMGKDVVAVEQK 167
Cdd:TIGR01083  81 RNKAKNIIELCRKLVERYGGEVPEDREELVKLPGVGRKTANVVLNVAFGIPAIAVDTHVFRVSNRLGLSKGKDPIKVEED 160

                         170       180       190
                  ....*....|....*....|....*....|..
gi 961462310  168 LEKVVPKEFKVDVHHWLILHGRYTCVARKPKC 199
Cdd:TIGR01083 161 LMKLVPREFWVKLHHWLILHGRYTCKARKPLC 192
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 35-188 6.43e-49

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 157.02  E-value: 6.43e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  35 FELLVAVTLSAQATDVGVNKATRKLFP-VANTPQAILDLGHDTLRDYIKTIGlFNSKAANVYKMCQILVDEHNSIV---P 110
Cdd:cd00056    1 FEVLVSEILSQQTTDKAVNKAYERLFErYGPTPEALAAADEEELRELIRSLG-YRRKAKYLKELARAIVEGFGGLVlddP 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961462310 111 ENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKL-AMGKDVVAVEQKLEKVVPKEFKVDVHHWLILHG 188
Cdd:cd00056   80 DAREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRLGLiPKKKTPEELEELLEELLPKPYWGEANQALMDLG 158
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 43-190 5.92e-48

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 154.34  E-value: 5.92e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310    43 LSAQATDVGVNKATRKLFPVANTPQAILDLGHDTLRDYIKTIGLFNSKAANVYKMCQILVDEHNSIVPENREALEALPGV 122
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIRGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 961462310   123 GRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKLAMGKDV-VAVEQKLEKVVPKEFKVDVHHWLILHGRY 190
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRLGLVDKKSTpEEVEKLLEKLLPEEDWRELNLLLIDFGRT 149
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 39-174 7.01e-36

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 123.16  E-value: 7.01e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310   39 VAVTLSAQATDVGVNKATRKLF-PVANTPQAILDLGHDTLRDYIKTIGLFNSKAANVYKMCQILVDEHNSIVPENREALE 117
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFeKFFPTPEDLADADEEELRELIRGLGFYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 961462310  118 A-LPGVGRKTANVVLNTAFG--WPVIAVDTHIFRVSNRTKLAMGKD-VVAVEQKLEKVVPK 174
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGrpDPLPVVDTHVRRVLKRLGLIKEKPtPKEVERELEELWPP 141
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 90-216 5.40e-14

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 69.40  E-value: 5.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  90 KAAnvykmcQILVDEHNSIVPENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNR-----TKLAMGKDVVAV 164
Cdd:COG1194   90 KAA------QQVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPAPIVDGNVKRVLSRlfaieGPIGSPAAKKEL 163

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 961462310 165 EQKLEKVVPKEfkvDVhhwlilhGRYT----------CVARKPKCGSCIIEDLCE-FKDKTEE 216
Cdd:COG1194  164 WALAEELLPPE---RP-------GDFNqalmdlgatvCTPKKPKCLLCPLQDDCAaFAEGRQE 216
PRK10880 PRK10880
adenine DNA glycosylase;
89-208 4.25e-10

adenine DNA glycosylase;


Pssm-ID: 182805 [Multi-domain]  Cd Length: 350  Bit Score: 58.18  E-value: 4.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  89 SKAANVYKMCQILVDEHNSIVPENREALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFRVSNRTKLAMG----KDvvaV 164
Cdd:PRK10880  84 ARARNLHKAAQQVATLHGGEFPETFEEVAALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARCYAVSGwpgkKE---V 160

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 961462310 165 EQKL----EKVVPKEFKVDVHHWLILHGRYTCVARKPKCGSCIIEDLC 208
Cdd:PRK10880 161 ENRLwqlsEQVTPAVGVERFNQAMMDLGAMVCTRSKPKCELCPLQNGC 208
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 10-146 2.24e-08

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 52.58  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  10 KRHQILTRLRDDNPHPETELEySSPFELLVAVTLSAQ-----------------ATDVGVNKATRKLFPvanTPQAILDL 72
Cdd:COG0122   61 ARDPVLAPLIERYPGLRLPRR-PDPFEALVRAILGQQvsvaaartiwrrlvalfGEPIEGPGGGLYAFP---TPEALAAA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  73 GHDTLRDyiktIGLFNSKAANVYKMCQILVDehNSIVPEN---------REALEALPGVGRKTANVVLNTAFGWP--VIA 141
Cdd:COG0122  137 SEEELRA----CGLSRRKARYLRALARAVAD--GELDLEAlaglddeeaIARLTALPGIGPWTAEMVLLFALGRPdaFPA 210


                 ....*
gi 961462310 142 VDTHI 146
Cdd:COG0122  211 GDLGL 215
PRK13910 PRK13910
DNA glycosylase MutY; Provisional
 57-216 1.09e-07

DNA glycosylase MutY; Provisional


Pssm-ID: 172427 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  57 RKLFPVANTPQAILDLGHDTLRDYI---KTIGLFnSKAANVYKMCQILVDEHNSIVPENREALEALPGVGRKTANVVLNT 133
Cdd:PRK13910  13 RFYSPFLEAFPTLKDLANAPLEEVLllwRGLGYY-SRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPGIGAYTANAILCF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310 134 AFGWPVIAVDTHIFRVSNRTkLAMGKDVVA--VEQKLEKVVPKEFKVDVHHWLILHGRYTCvARKPKCGSCIIEDLCEFK 211
Cdd:PRK13910  92 GFREKSACVDANIKRVLLRL-FGLDPNIHAkdLQIKANDFLNLNESFNHNQALIDLGALIC-SPKPKCAICPLNPYCLGK 169


                 ....*
gi 961462310 212 DKTEE 216
Cdd:PRK13910 170 NNPEK 174
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 104-131 2.67e-06

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 42.79  E-value: 2.67e-06
                          10        20
                  ....*....|....*....|....*...
gi 961462310  104 EHNSIVPENREALEALPGVGRKTANVVL 131
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAIL 28
FES smart00525
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ...
 191-211 4.40e-05

iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3);


Pssm-ID: 197771 [Multi-domain]  Cd Length: 21  Bit Score: 39.07  E-value: 4.40e-05
                           10        20
                   ....*....|....*....|.
gi 961462310   191 TCVARKPKCGSCIIEDLCEFK 211
Cdd:smart00525   1 ICTARKPRCDECPLKDLCPAY 21
EndIII_4Fe-2S pfam10576
Iron-sulfur binding domain of endonuclease III; Escherichia coli endonuclease III (EC 4.2.99. ...
 192-208 1.33e-04

Iron-sulfur binding domain of endonuclease III; Escherichia coli endonuclease III (EC 4.2.99.18) is a DNA repair enzyme that acts both as a DNA N-glycosylase, removing oxidized pyrimidines from DNA, and as an apurinic/apyrimidinic (AP) endonuclease, introducing a single-strand nick at the site from which the damaged base was removed. Endonuclease III is an iron-sulfur protein that binds a single 4Fe-4S cluster. The 4Fe-4S cluster does not seem to be important for catalytic activity, but is probably involved in the proper positioning of the enzyme along the DNA strand. The 4Fe-4S cluster is bound by four cysteines which are all located in a 17 amino acid region at the C-terminal end of endonuclease III. A similar region is also present in the central section of mutY and in the C-terminus of ORF-10 and of the Micro-coccus UV endonuclease.


Pssm-ID: 463153 [Multi-domain]  Cd Length: 17  Bit Score: 37.75  E-value: 1.33e-04
                          10
                  ....*....|....*..
gi 961462310  192 CVARKPKCGSCIIEDLC 208
Cdd:pfam10576   1 CTARKPKCEECPLADLC 17
PRK13913 PRK13913
3-methyladenine DNA glycosylase; Provisional
 35-148 4.91e-04

3-methyladenine DNA glycosylase; Provisional


Pssm-ID: 184390  Cd Length: 218  Bit Score: 39.83  E-value: 4.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 961462310  35 FELLVAVTLSAQATDVGVNKAT---RKLFPVANTPQAIL-DLGH---DTLRDYIKTIGLFNSKAANVYKMCQILVDEHNS 107
Cdd:PRK13913  31 FEALLGAVLTQNTKFEAVEKSLenlKNAFILENDDEINLkKIAYiefSKLAECVRPSGFYNQKAKRLIDLSENILKDFGS 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 961462310 108 I--VPEN--REALEALPGVGRKTANVVLNTAFGWPVIAVDTHIFR 148
Cdd:PRK13913 111 FenFKQEvtREWLLDQKGIGKESADAILCYVCAKEVMVVDKYSYL 155
ogg TIGR00588
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ...
 111-152 2.30e-03

8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 211589 [Multi-domain]  Cd Length: 310  Bit Score: 38.35  E-value: 2.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 961462310  111 ENREALEALPGVGRKTANVVLNTAFGWP-VIAVDTHIFRVSNR 152
Cdd:TIGR00588 217 DAREALCELPGVGPKVADCICLMGLDKPqAVPVDVHVWRIANR 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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