NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|959125786|ref|YP_009186315|]
View 

NADH dehydrogenase subunit 2 (mitochondrion) [Teleogryllus oceanicus]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND2 super family cl31798
NADH dehydrogenase subunit 2; Provisional
 1-58 1.64e-14

NADH dehydrogenase subunit 2; Provisional


The actual alignment was detected with superfamily member MTH00105:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 73.34  E-value: 1.64e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQA 58
Cdd:MTH00105   7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQA 64
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-303 7.31e-13

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00160:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 335  Bit Score: 68.31  E-value: 7.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQAMHRLQFHFVFYKCKILLTSLKL 80
Cdd:MTH00160   8 LLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFNN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786  81 FNN-------MLKLEQ------HHSMYDFLLWSKDYHDSTasfwLHDKNSLHLLSYLIYHPINQLSY--------SYYYH 139
Cdd:MTH00160  88 ISSmlinsslLLKLGAapfhfwFPEVMEGLSWINCFILMT----WQKIAPLILLSYLINNNFIIIIIilsaiigaIGGLN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786 140 QFLLVQLEDYIKHQHVKSYLtpLLIMLDEYYYDYQYQKISDNFTSLFMQFYQQQFWWSSPMFPPNIqisfhldeIHQYSI 219
Cdd:MTH00160 164 QTSLRKILAYSSINHLGWML--SSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNN--------KSKKIK 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786 220 FLFQLILYLLEDYLHFYEFLPKWMIIQNSCHNNLQFMALIMILFTLITLIYYLRLMMSSFLINVNQLKWNYSQWYQNMIN 299
Cdd:MTH00160 234 FLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSL 313


                 ....
gi 959125786 300 YNWI 303
Cdd:MTH00160 314 ILNF 317
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-58 1.64e-14

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 73.34  E-value: 1.64e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQA 58
Cdd:MTH00105   7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQA 64
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-303 7.31e-13

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 68.31  E-value: 7.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQAMHRLQFHFVFYKCKILLTSLKL 80
Cdd:MTH00160   8 LLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFNN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786  81 FNN-------MLKLEQ------HHSMYDFLLWSKDYHDSTasfwLHDKNSLHLLSYLIYHPINQLSY--------SYYYH 139
Cdd:MTH00160  88 ISSmlinsslLLKLGAapfhfwFPEVMEGLSWINCFILMT----WQKIAPLILLSYLINNNFIIIIIilsaiigaIGGLN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786 140 QFLLVQLEDYIKHQHVKSYLtpLLIMLDEYYYDYQYQKISDNFTSLFMQFYQQQFWWSSPMFPPNIqisfhldeIHQYSI 219
Cdd:MTH00160 164 QTSLRKILAYSSINHLGWML--SSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNN--------KSKKIK 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786 220 FLFQLILYLLEDYLHFYEFLPKWMIIQNSCHNNLQFMALIMILFTLITLIYYLRLMMSSFLINVNQLKWNYSQWYQNMIN 299
Cdd:MTH00160 234 FLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSL 313


                 ....
gi 959125786 300 YNWI 303
Cdd:MTH00160 314 ILNF 317
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-58 1.64e-14

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 73.34  E-value: 1.64e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQA 58
Cdd:MTH00105   7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQA 64
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-59 3.13e-13

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 69.47  E-value: 3.13e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQAM 59
Cdd:MTH00112   7 LIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAA 65
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 1-59 4.77e-13

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 68.76  E-value: 4.77e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQAM 59
Cdd:MTH00144   7 LLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSL 65
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-303 7.31e-13

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 68.31  E-value: 7.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQAMHRLQFHFVFYKCKILLTSLKL 80
Cdd:MTH00160   8 LLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNMLNLMLFNN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786  81 FNN-------MLKLEQ------HHSMYDFLLWSKDYHDSTasfwLHDKNSLHLLSYLIYHPINQLSY--------SYYYH 139
Cdd:MTH00160  88 ISSmlinsslLLKLGAapfhfwFPEVMEGLSWINCFILMT----WQKIAPLILLSYLINNNFIIIIIilsaiigaIGGLN 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786 140 QFLLVQLEDYIKHQHVKSYLtpLLIMLDEYYYDYQYQKISDNFTSLFMQFYQQQFWWSSPMFPPNIqisfhldeIHQYSI 219
Cdd:MTH00160 164 QTSLRKILAYSSINHLGWML--SSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNN--------KSKKIK 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786 220 FLFQLILYLLEDYLHFYEFLPKWMIIQNSCHNNLQFMALIMILFTLITLIYYLRLMMSSFLINVNQLKWNYSQWYQNMIN 299
Cdd:MTH00160 234 FLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSL 313


                 ....
gi 959125786 300 YNWI 303
Cdd:MTH00160 314 ILNF 317
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 2-59 7.85e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 65.33  E-value: 7.85e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 959125786   2 LFMMM--LILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQAM 59
Cdd:MTH00070   6 LSILLssLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQAS 65
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-58 3.03e-11

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 63.29  E-value: 3.03e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQA 58
Cdd:MTH00135   7 TILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQA 64
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-59 1.29e-10

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 61.33  E-value: 1.29e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQAM 59
Cdd:MTH00011   9 FLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQAL 67
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-59 1.46e-10

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 61.52  E-value: 1.46e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQAM 59
Cdd:MTH00200   7 PLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQAT 65
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-59 6.03e-09

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 56.48  E-value: 6.03e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQAM 59
Cdd:MTH00041   7 IFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAF 65
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 1-58 5.65e-07

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 50.44  E-value: 5.65e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 959125786   1 MLFMMMLILGTMISISSNSWPATWMGLEINLLAFIPLMSSKSNMMSTEAAMKYFIVQA 58
Cdd:MTH00197   1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQE 58
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
4-59 9.46e-04

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 40.57  E-value: 9.46e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 959125786   4 MMMLILGTMISISSNSWPATWMGLEINLLA-FIPLMSSKSNMMSTEAAMKYFIVQAM 59
Cdd:PRK05777 109 VLFALLGMMVMVSANDLLTLFLGLELLSLPlYALAALRRDRRRSLEAAIKYFVLGAL 165
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 238-274 3.53e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 38.63  E-value: 3.53e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 959125786 238 FLPKWMIIQNSCHNNLQFMALIMILFTLITLIYYLRL 274
Cdd:MTH00135 259 FMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRL 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH