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Conserved domains on  [gi|952999221|gb|ALO28936|]
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outer membrane protein/peptidoglycan-associated (lipo)protein [Porphyromonas gingivalis A7A1-28]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OmpA super family cl34510
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 204-290 3.55e-06

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG2885:

Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 48.63  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 204 YQVGKYVVLPQFDgnpAELARIDSKLKELGNdsdiifEKLSMVGYASPEGGVEYNAKLSKDRAHSFASYLVNKyPILKSR 283
Cdd:COG2885  191 FDFDSAELTPEAK---AALDELAALLKENPD------LRIEIEGHTDSRGSDAYNLALSERRAEAVKDYLVSK-GIPASR 260


                 ....*..
gi 952999221 284 FEYDWKG 290
Cdd:COG2885  261 ITAVGYG 267
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 376-488 2.01e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.41  E-value: 2.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 376 RLSLAEVYAVAQSYPEGsherYETWTIAEKTFPKAIEPTANAAIIDLRAGRYPQALARL----EARNSEPKLWMLLGLAY 451
Cdd:COG4783    7 LYALAQALLLAGDYDEA----EALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLhealELDPDEPEARLNLGLAL 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 952999221 452 AYSEKWAEAESYLTRAAQQ--GQPGAQHNLNELRRYMQD 488
Cdd:COG4783   83 LKAGDYDEALALLEKALKLdpEHPEAYLRLARAYRALGR 121
DUF3868 super family cl15216
Domain of unknown function, B. Theta Gene description (DUF3868); Based on Bacteroides ...
 4-88 3.17e-04

Domain of unknown function, B. Theta Gene description (DUF3868); Based on Bacteroides thetaiotaomicron gene BT_1065, a putative uncharacterized protein As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or other bacterial species vs when in culture.


The actual alignment was detected with superfamily member pfam12984:

Pssm-ID: 432918  Cd Length: 109  Bit Score: 40.16  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221    4 SRYIILSFLFGMSTLAVTGQTHLGGIKVSEKHVVKKtGHTANVKMDLDLTAMpDMNSNLLMVVTPIIRSNTSNDQVALRP 83
Cdd:pfam12984   2 KKTFILLSLAICGLVAQAQNAYEGVISVKPHQLEVR-GDSVFVNMDIDLENV-KLKSKQMVILTPILRSQDGTELQQLPK 79


                  ....*
gi 952999221   84 FLLMG 88
Cdd:pfam12984  80 VVIKG 84
 
Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 204-290 3.55e-06

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 48.63  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 204 YQVGKYVVLPQFDgnpAELARIDSKLKELGNdsdiifEKLSMVGYASPEGGVEYNAKLSKDRAHSFASYLVNKyPILKSR 283
Cdd:COG2885  191 FDFDSAELTPEAK---AALDELAALLKENPD------LRIEIEGHTDSRGSDAYNLALSERRAEAVKDYLVSK-GIPASR 260


                 ....*..
gi 952999221 284 FEYDWKG 290
Cdd:COG2885  261 ITAVGYG 267
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 207-292 6.90e-06

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 44.85  E-value: 6.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 207 GKYVVLPQFDgnpAELARIDSKLKELGNdsdiifEKLSMVGYASPEGGVEYNAKLSKDRAHSFASYLVNKYpILKSRFEY 286
Cdd:cd07185    9 GSAELTPEAK---PLLDKLAEVLKKNPD------AKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKG-VDASRITA 78


                 ....*.
gi 952999221 287 DWKGQD 292
Cdd:cd07185   79 VGYGES 84
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 376-488 2.01e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.41  E-value: 2.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 376 RLSLAEVYAVAQSYPEGsherYETWTIAEKTFPKAIEPTANAAIIDLRAGRYPQALARL----EARNSEPKLWMLLGLAY 451
Cdd:COG4783    7 LYALAQALLLAGDYDEA----EALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLhealELDPDEPEARLNLGLAL 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 952999221 452 AYSEKWAEAESYLTRAAQQ--GQPGAQHNLNELRRYMQD 488
Cdd:COG4783   83 LKAGDYDEALALLEKALKLdpEHPEAYLRLARAYRALGR 121
DUF3868 pfam12984
Domain of unknown function, B. Theta Gene description (DUF3868); Based on Bacteroides ...
 4-88 3.17e-04

Domain of unknown function, B. Theta Gene description (DUF3868); Based on Bacteroides thetaiotaomicron gene BT_1065, a putative uncharacterized protein As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or other bacterial species vs when in culture.


Pssm-ID: 432918  Cd Length: 109  Bit Score: 40.16  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221    4 SRYIILSFLFGMSTLAVTGQTHLGGIKVSEKHVVKKtGHTANVKMDLDLTAMpDMNSNLLMVVTPIIRSNTSNDQVALRP 83
Cdd:pfam12984   2 KKTFILLSLAICGLVAQAQNAYEGVISVKPHQLEVR-GDSVFVNMDIDLENV-KLKSKQMVILTPILRSQDGTELQQLPK 79


                  ....*
gi 952999221   84 FLLMG 88
Cdd:pfam12984  80 VVIKG 84
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 220-290 9.66e-04

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 38.50  E-value: 9.66e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 952999221  220 AELARIDSKLKELGNDSDIIFEklsmvGYASPEGGVEYNAKLSKDRAHSFASYLVNKYpILKSRFEYDWKG 290
Cdd:pfam00691  14 ATLDEIADLLKFPELKNTITIE-----GHTDTVGSAAYNWELSQRRAEAVRRYLVNFG-VPPSRISVVGYG 78
 
Name Accession Description Interval E-value
OmpA COG2885
Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall ...
 204-290 3.55e-06

Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442131 [Multi-domain]  Cd Length: 294  Bit Score: 48.63  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 204 YQVGKYVVLPQFDgnpAELARIDSKLKELGNdsdiifEKLSMVGYASPEGGVEYNAKLSKDRAHSFASYLVNKyPILKSR 283
Cdd:COG2885  191 FDFDSAELTPEAK---AALDELAALLKENPD------LRIEIEGHTDSRGSDAYNLALSERRAEAVKDYLVSK-GIPASR 260


                 ....*..
gi 952999221 284 FEYDWKG 290
Cdd:COG2885  261 ITAVGYG 267
OmpA_C-like cd07185
Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; ...
 207-292 6.90e-06

Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; OmpA-like domains (named after the C-terminal domain of Escherichia coli OmpA protein) have been shown to non-covalently associate with peptidoglycan, a network of glycan chains composed of disaccharides, which are crosslinked via short peptide bridges. Well-studied members of this family include the Escherichia coli outer membrane protein OmpA, the Escherichia coli lipoprotein PAL, Neisseria meningitdis RmpM, which interact with the outer membrane, as well as the Escherichia coli motor protein MotB, and the Vibrio flagellar motor proteins PomB and MotY, which interact with the inner membrane.


Pssm-ID: 143586 [Multi-domain]  Cd Length: 106  Bit Score: 44.85  E-value: 6.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 207 GKYVVLPQFDgnpAELARIDSKLKELGNdsdiifEKLSMVGYASPEGGVEYNAKLSKDRAHSFASYLVNKYpILKSRFEY 286
Cdd:cd07185    9 GSAELTPEAK---PLLDKLAEVLKKNPD------AKIRIEGHTDSRGSDAYNQELSERRAEAVADYLVSKG-VDASRITA 78


                 ....*.
gi 952999221 287 DWKGQD 292
Cdd:cd07185   79 VGYGES 84
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 376-488 2.01e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.41  E-value: 2.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 376 RLSLAEVYAVAQSYPEGsherYETWTIAEKTFPKAIEPTANAAIIDLRAGRYPQALARL----EARNSEPKLWMLLGLAY 451
Cdd:COG4783    7 LYALAQALLLAGDYDEA----EALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLhealELDPDEPEARLNLGLAL 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 952999221 452 AYSEKWAEAESYLTRAAQQ--GQPGAQHNLNELRRYMQD 488
Cdd:COG4783   83 LKAGDYDEALALLEKALKLdpEHPEAYLRLARAYRALGR 121
DUF3868 pfam12984
Domain of unknown function, B. Theta Gene description (DUF3868); Based on Bacteroides ...
 4-88 3.17e-04

Domain of unknown function, B. Theta Gene description (DUF3868); Based on Bacteroides thetaiotaomicron gene BT_1065, a putative uncharacterized protein As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or other bacterial species vs when in culture.


Pssm-ID: 432918  Cd Length: 109  Bit Score: 40.16  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221    4 SRYIILSFLFGMSTLAVTGQTHLGGIKVSEKHVVKKtGHTANVKMDLDLTAMpDMNSNLLMVVTPIIRSNTSNDQVALRP 83
Cdd:pfam12984   2 KKTFILLSLAICGLVAQAQNAYEGVISVKPHQLEVR-GDSVFVNMDIDLENV-KLKSKQMVILTPILRSQDGTELQQLPK 79


                  ....*
gi 952999221   84 FLLMG 88
Cdd:pfam12984  80 VVIKG 84
OmpA pfam00691
OmpA family; The Pfam entry also includes MotB and related proteins which are not included in ...
 220-290 9.66e-04

OmpA family; The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.


Pssm-ID: 425825 [Multi-domain]  Cd Length: 95  Bit Score: 38.50  E-value: 9.66e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 952999221  220 AELARIDSKLKELGNDSDIIFEklsmvGYASPEGGVEYNAKLSKDRAHSFASYLVNKYpILKSRFEYDWKG 290
Cdd:pfam00691  14 ATLDEIADLLKFPELKNTITIE-----GHTDTVGSAAYNWELSQRRAEAVRRYLVNFG-VPPSRISVVGYG 78
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 363-476 1.07e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 363 LDKAREIIKTHP----SRLSLAEVYAVAQSYPEgSHERYETwtiAEKTFPKAIEPTANAAIIDLRAGRYPQALARLE--- 435
Cdd:COG4235    3 IARLRQALAANPndaeGWLLLGRAYLRLGRYDE-ALAAYEK---ALRLDPDNADALLDLAEALLAAGDTEEAEELLEral 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 952999221 436 ARN-SEPKLWMLLGLAYAYSEKWAEAESYLTRAAQQGQPGAQ 476
Cdd:COG4235   79 ALDpDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 363-470 1.33e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 363 LDKAREIIKTHPS----RLSLAEVYAVAQSYPEGShERYETwtiAEKTFPKAIEPTANAAIIDLRAGRYPQALARLE--- 435
Cdd:COG4783   24 EALLEKALELDPDnpeaFALLGEILLQLGDLDEAI-VLLHE---ALELDPDEPEARLNLGLALLKAGDYDEALALLEkal 99

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 952999221 436 ARNSE-PKLWMLLGLAYAYSEKWAEAESYLTRAAQQ 470
Cdd:COG4783  100 KLDPEhPEAYLRLARAYRALGRPDEAIAALEKALEL 135
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 361-488 1.77e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.17  E-value: 1.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 361 FELDKAREIIKTHPSRLSLAEVYAVAQSYPEGSHERYETWTIAEKTFPKAIEPTANAAIIDLRAGRYPQALAR----LEA 436
Cdd:COG5010    4 LEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALleqaLQL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 952999221 437 RNSEPKLWMLLGLAYAYSEKWAEAESYLTRAAQ--QGQPGAQHNLNELRRYMQD 488
Cdd:COG5010   84 DPNNPELYYNLALLYSRSGDKDEAKEYYEKALAlsPDNPNAYSNLAALLLSLGQ 137
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 417-472 3.25e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 39.51  E-value: 3.25e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 952999221 417 AAIIDLRAGRYPQALARLEARNSE----PKLWMLLGLAYAYSEKWAEAESYLTRAAQQGQ 472
Cdd:COG3071  230 RLYGRLQGGDPAKQLKRAEKWLKKhpndPDLLLALGRLCLRNQLWGKAREYLEAALALRP 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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