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Conserved domains on  [gi|952977797|ref|NP_001304019|]
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potassium channel subfamily K member 4 [Homo sapiens]

Protein Classification

potassium channel family protein( domain architecture ID 10545436)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes

Gene Ontology:  GO:0005267|GO:0034220|GO:0005216|GO:0071805|GO:0016020
PubMed:  15816170|9525859|11836519|11178249|1772658
SCOP:  4000034
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 88-142 1.48e-17

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 76.54  E-value: 1.48e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 952977797   88 WDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRL 142
Cdd:pfam07885  22 WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 180-258 1.08e-13

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 65.75  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977797  180 CLLFVLTPTFVFCYMED---WSKLEAIYFVIVTLTTVGFGDYVAGadprqdSPAYQPLVWFWILLGLAYFASVLTTIGNW 256
Cdd:pfam07885   2 VLLLVLIFGTVYYLLEEgweWSFLDALYFSFVTLTTVGYGDIVPL------TDAGRLFTIFYILIGIPLFAIFLAVLGRF 75


                  ..
gi 952977797  257 LR 258
Cdd:pfam07885  76 LT 77
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 88-142 1.48e-17

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 76.54  E-value: 1.48e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 952977797   88 WDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRL 142
Cdd:pfam07885  22 WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 180-258 1.08e-13

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 65.75  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977797  180 CLLFVLTPTFVFCYMED---WSKLEAIYFVIVTLTTVGFGDYVAGadprqdSPAYQPLVWFWILLGLAYFASVLTTIGNW 256
Cdd:pfam07885   2 VLLLVLIFGTVYYLLEEgweWSFLDALYFSFVTLTTVGYGDIVPL------TDAGRLFTIFYILIGIPLFAIFLAVLGRF 75


                  ..
gi 952977797  257 LR 258
Cdd:pfam07885  76 LT 77
PRK10537 PRK10537
voltage-gated potassium channel protein;
202-253 2.69e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 39.62  E-value: 2.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 952977797 202 AIYFVIVTLTTVGFGDYVagadPRqdSPAYQPLVWFWILLGLAYFASVLTTI 253
Cdd:PRK10537 172 AFYFSIVTMSTVGYGDIV----PV--SESARLFTISVIILGITVFATSISAI 217
TrkG COG0168
Trk-type K+ transport system, membrane component [Inorganic ion transport and metabolism];
93-216 3.67e-03

Trk-type K+ transport system, membrane component [Inorganic ion transport and metabolism];


Pssm-ID: 439938 [Multi-domain]  Cd Length: 414  Bit Score: 39.29  E-value: 3.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977797  93 AFFFSGTIITTIGYGNV--ALRTDAGRLFCIFYALVG---------IPL--FGILLAGVGDRLgSSLRHGIGHIEAIFLK 159
Cdd:COG0168  239 ALFQVVSILTTTGFATVdyGQWPPFSLLLLILLMFIGgsagstaggIKVtrFAVLLKAIRREL-RRLIHPNAVRPVRIGG 317

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 952977797 160 WHVPPELVRvlSAMLFLLIGCLLFVLTpTFVFCYMEDWSKLEAIYFVIVTLTTVGFG 216
Cdd:COG0168  318 RRIPEEVIR--KALAFFFLYLLLVVVG-TLLLSLTEGLDFLTALFEVASAFGNVGLS 371
PRK10537 PRK10537
voltage-gated potassium channel protein;
89-154 6.03e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 38.46  E-value: 6.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 952977797  89 DLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGV-----GDRLGSSLRHGIGHIE 154
Cdd:PRK10537 168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIfgpviRGNLKRLVKGRISHMH 238
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 88-142 1.48e-17

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 76.54  E-value: 1.48e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 952977797   88 WDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRL 142
Cdd:pfam07885  22 WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 180-258 1.08e-13

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 65.75  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977797  180 CLLFVLTPTFVFCYMED---WSKLEAIYFVIVTLTTVGFGDYVAGadprqdSPAYQPLVWFWILLGLAYFASVLTTIGNW 256
Cdd:pfam07885   2 VLLLVLIFGTVYYLLEEgweWSFLDALYFSFVTLTTVGYGDIVPL------TDAGRLFTIFYILIGIPLFAIFLAVLGRF 75


                  ..
gi 952977797  257 LR 258
Cdd:pfam07885  76 LT 77
PRK10537 PRK10537
voltage-gated potassium channel protein;
202-253 2.69e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 39.62  E-value: 2.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 952977797 202 AIYFVIVTLTTVGFGDYVagadPRqdSPAYQPLVWFWILLGLAYFASVLTTI 253
Cdd:PRK10537 172 AFYFSIVTMSTVGYGDIV----PV--SESARLFTISVIILGITVFATSISAI 217
TrkG COG0168
Trk-type K+ transport system, membrane component [Inorganic ion transport and metabolism];
93-216 3.67e-03

Trk-type K+ transport system, membrane component [Inorganic ion transport and metabolism];


Pssm-ID: 439938 [Multi-domain]  Cd Length: 414  Bit Score: 39.29  E-value: 3.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977797  93 AFFFSGTIITTIGYGNV--ALRTDAGRLFCIFYALVG---------IPL--FGILLAGVGDRLgSSLRHGIGHIEAIFLK 159
Cdd:COG0168  239 ALFQVVSILTTTGFATVdyGQWPPFSLLLLILLMFIGgsagstaggIKVtrFAVLLKAIRREL-RRLIHPNAVRPVRIGG 317

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 952977797 160 WHVPPELVRvlSAMLFLLIGCLLFVLTpTFVFCYMEDWSKLEAIYFVIVTLTTVGFG 216
Cdd:COG0168  318 RRIPEEVIR--KALAFFFLYLLLVVVG-TLLLSLTEGLDFLTALFEVASAFGNVGLS 371
PRK10537 PRK10537
voltage-gated potassium channel protein;
89-154 6.03e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 38.46  E-value: 6.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 952977797  89 DLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGV-----GDRLGSSLRHGIGHIE 154
Cdd:PRK10537 168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIfgpviRGNLKRLVKGRISHMH 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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