|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
18-402 |
2.68e-78 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 247.28 E-value: 2.68e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 18 ARRRGLHGLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLR 97
Cdd:PRK11646 7 ARNLGKYFLLIDNMLVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 98 AAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALLHYDFRVV 177
Cdd:PRK11646 87 AAGFATMAIAHEPWLLWLSCILSGLGGTLFDPPRTALVIKLIRPHQRGRFFSLLMMQDSAGAVIGALLGSWLLQYDFRLV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 178 CLAAAACFAVNFLV-ALRLPQVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLYWFVAVQINISFPLLAQRLTGTVDSVG 256
Cdd:PRK11646 167 CATGAVLFVLAAAFnAWLLPAYKLSTVRTPVREGMTRVLRDKRFVTYVLTLTGYYMLAVQVMLMLPIMVNDIAGSPSAVK 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 257 VMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLA 336
Cdd:PRK11646 247 WMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTLICLFYIGSIIAEPARETLSASLA 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 951710016 337 DPRALGTFLGVSSLSLAVGGGIGNIAGGWMVDLAATKQWPWLPWAVFCVVGLASAFGLHQATRVRR 402
Cdd:PRK11646 327 DARARGSYMGFSRLGLALGGAIGYIGGGWLFDLGKALNQPELPWMMLGIIGLITLLALYWQFSQKR 392
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
23-394 |
2.26e-58 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 195.14 E-value: 2.26e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 23 LHGLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFA 102
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 103 SLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALLHYDFRVVCLAAA 182
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 183 ACFAVNFLVALRLPQVRMPDRPPPLRH----GLDLVRGNRAFIVLVGLMMLYWFVAVQINISFPLLAQRLTGTVDS-VGV 257
Cdd:cd17329 161 VLFLLAALVLLFLLPETRPKRRAAEKTeilrGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESlLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 258 MFALSAGLTVALQYGLVRWLErRWSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLAD 337
Cdd:cd17329 241 LLALNALLIVLLQFPVARLVE-RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 951710016 338 PRALGTFLGVSSLSLAVGGGIGNIAGGWMVDLAAtkqwPWLPWAVFCVVGLASAFGL 394
Cdd:cd17329 320 PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLG----PGLPWLILAALGLIAAALL 372
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-354 |
2.03e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 111.60 E-value: 2.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 19 RRRGLHGLLVYTFLMVTGFAMLMPLVAVhFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLRA 98
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 99 AGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALL-HYDFRVV 177
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 178 CLAAAACFAVNFLVALRLPQVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLYWFVAVQINISFPLLAQRLTGTVDSVGV 257
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 258 MFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLAD 337
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
330
....*....|....*..
gi 951710016 338 PRALGTFLGVSSLSLAV 354
Cdd:COG2814 327 PEARGRASGLYNSAFFL 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-392 |
1.46e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 106.89 E-value: 1.46e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 26 LLVYTFLMVTGFAMLMPLVAVhFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLA 105
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPL-YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 106 FADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALL-HYDFRVVCLAAAAC 184
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 185 FAVNFLVALRL------PQVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLYWFVAVQINISFPLLAQRLTGTVDS-VGV 257
Cdd:cd17325 160 ALLALVLALLLlpeprpPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAqIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 258 MFALSAGLTVALQYGLVRWLERrWSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLAD 337
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 951710016 338 PRALGTFLGVSSLSLAVGGGIGNIAGGWMVDLAATkQWPWLPWAVFCVVGLASAF 392
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF-ATPFLAAAALLLLAAVLFL 372
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
73-347 |
4.05e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 96.87 E-value: 4.05e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 73 LALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISN 152
Cdd:cd17474 50 LMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYE 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 153 WISGVATTLGPLLGVALLHYDFRVVCLAAAACFAVNFLVALRLPQVRMPDRPPP----LRHGLDLVRGNRAFIVLVGLMM 228
Cdd:cd17474 130 AALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSsatkLRDLKKALRGRGLLTFLVSAFL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 229 LYW-FVAVQINISFpLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDF 307
Cdd:cd17474 210 YFFlYFAFLTYLPF-LLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSL 288
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 951710016 308 AGLLICVGAFSIGALMTRPTQQTLIAGLADPRALGTFLGV 347
Cdd:cd17474 289 ALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL 328
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
26-392 |
1.49e-19 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 89.17 E-value: 1.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 26 LLVYTFLMVTGFAMLMPLVA--VHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFAS 103
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPfyVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 104 LAFADALPMLLCAMLLSALGGAMFeAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALLH-YDFRVVCLAAA 182
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTpYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 183 ACFAVNFLVALRLPqvrmpdrpPPLRhgldlvrgnrafiVLVGLMMLYWFVAVQINISFPL-LAQRLTGTVDSVGVMFAL 261
Cdd:cd17330 160 ALALLNLVLVLFFL--------PPLR-------------RLLLVYFLIALAFAGLESVFSLfLKDRFGFSPSQIGLLLAL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 262 SAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLADPRAL 341
Cdd:cd17330 219 VGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQ 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 951710016 342 GTFLGVSSLSLAVGGGIGNIAGGWMVDLAAtKQWPWLPWAVFCVVGLASAF 392
Cdd:cd17330 299 GKAQGIIQSLQSLARIIGPLLAGPLYSFLG-PGVPFLLAAGLLLIALFLLS 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-392 |
6.65e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 87.48 E-value: 6.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 26 LLVYTFLMVTGFAMLMPLVaVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLA 105
Cdd:cd06174 1 LLLGFFLTGLARGLISPLL-PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 106 FADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALLHY---DFRVVCLAAA 182
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 183 ACFAVNFLVALRLP--------QVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLYWFVAVQINISFP-LLAQRLTGTVD 253
Cdd:cd06174 160 ALALLAAILLLLVVpdppesarAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPlFLLDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 254 SVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIA 333
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 951710016 334 GLADPRALGTFLGVSSLSLAVGGGIGNIAGGWMVDLAATKQWPWLPWAVFCVVGLASAF 392
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
26-354 |
7.01e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.09 E-value: 7.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 26 LLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLA 105
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 106 FADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALL-HYDFRVVCLAAAAC 184
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 185 FAVNFLVALRLPQVRMPDRPPPLRHGLDLVRG------NRAFIVLVGLMMLYWFVAVQINISFPLLAQRLTGTVDSVGVM 258
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVawkallRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 259 FALSAGLTVALQYGLVRWLER--RWSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLA 336
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRlgRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330
....*....|....*...
gi 951710016 337 DPRALGTFLGVSSLSLAV 354
Cdd:pfam07690 321 PKEERGTASGLYNTAGSL 338
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
26-304 |
1.92e-15 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 77.29 E-value: 1.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 26 LLVYTFLMVTGFAMLMPLVA---VHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFA 102
Cdd:cd17388 4 ILVTVLLDAMGIGLIMPVLPtllREFVGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 103 SLAFADALPMLLCAMLLSALGGAMFeAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALLHYDFRVVCLAAA 182
Cdd:cd17388 84 LMAFAPTLWWLYLGRIIAGITGATG-AVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 183 ACFAVNFLVALR-LPQVRMPDRPPPLRHG----LDLVRGNRAFIVLVGLMMLYWFVAVQINISFPLLA----QRLTGTVD 253
Cdd:cd17388 163 GLNGLNFLLGLFvLPESLPPERRRAFRWRranpFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVlfteDRFDWSPT 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 951710016 254 SVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGvvvmsLAAGAIGLV 304
Cdd:cd17388 243 MVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLG-----LAADALGFL 288
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
76-370 |
2.04e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 74.55 E-value: 2.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 76 VGGVLSDRYGARR-----MICLGVLLRAAGFASLAFADALP------MLLCAMLLSALGGAMFEAPYQASIAALT-DENT 143
Cdd:COG2211 65 LIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAELTpDYEE 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 144 RPRYYAISNWISGVATTLGPLLGVALLHY-------DFRVVCLAAAACFAVNFLVALRL--PQVRMPDRPPPLRHGLDLV 214
Cdd:COG2211 145 RTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYRLTALIFAVLGLLAFLLTFFGtkERPVPEEEKVSLKESLKAL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 215 RGNRAFIVLVGLMMLYWFVAVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVM 294
Cdd:COG2211 225 LKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 295 SLAAGAIGLVR--DFAGLLICVGAFSIGALMTRPTQQTLIAGLADP-------RALGTFLGVSSLSLAVGGGIGNIAGGW 365
Cdd:COG2211 305 ALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYdewktgrRREGLYFGIFTFAIKLGQALAGALAGL 384
|
....*
gi 951710016 366 MVDLA 370
Cdd:COG2211 385 LLALF 389
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
26-296 |
1.29e-13 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 71.81 E-value: 1.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 26 LLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICL-GVLLRAAGFASL 104
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILlALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 105 AFADALPMLLC-AMLLSALGGAMFEA--PYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALL-HYDFRVVCLA 180
Cdd:cd17471 81 AFLRNYWVLLLvGVVLLSLGAAAFPQlfALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLdVLGFTGLFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 181 AAACFAVNFLVALR-LPQVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLYWFVAVQINISFPL-LAQRLTGTVDSVGVM 258
Cdd:cd17471 161 AALLYLVVALLVLFlLPSVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLyVTNELGGSESWVGLL 240
|
250 260 270
....*....|....*....|....*....|....*...
gi 951710016 259 FALSAGLTVALQYGLVRWLeRRWSSAQVLVAGVVVMSL 296
Cdd:cd17471 241 FGLAAALEIPIMLLAGLLA-KRFGKRRLLLAGFLAGVL 277
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-195 |
1.64e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.45 E-value: 1.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 12 ATLSEAARRRGLHGLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMIC 91
Cdd:cd17325 190 SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 92 LGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALL- 170
Cdd:cd17325 270 IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYd 349
|
170 180
....*....|....*....|....*
gi 951710016 171 HYDFRVVCLAAAACFAVNFLVALRL 195
Cdd:cd17325 350 AFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
73-392 |
2.04e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 71.11 E-value: 2.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 73 LALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADA-----LPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRY 147
Cdd:cd06173 50 FSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALlgslsLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 148 YAISNWISGVATTLGPLLG---VALLHYDFRVVCLAAAACFAVNFLVALRLPQVRMPDRPPP-----LRHGLDLVRGNRA 219
Cdd:cd06173 130 NALNSLATQLARIIGPALGgllVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSlllrdLREGLRYLRRSPL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 220 FIVLVGLMMLYWFVAVQINISFPLLAQR-LTGTVDSVGVMFALSA--GLTVALqygLVRWLERRWSSAQVLVAGVVVMSL 296
Cdd:cd06173 210 LRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGvgALLGAL---LLGRLSKRRRRGRLLLIGALLLGL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 297 AAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLADPRALGTFLGVSSLSLAVGGGIGNIAGGWMVDLAATKQWP 376
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
330
....*....|....*.
gi 951710016 377 WLPWAVFCVVGLASAF 392
Cdd:cd06173 367 LLAGALLLLAALLLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
25-399 |
8.60e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 69.13 E-value: 8.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 25 GLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASL 104
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 105 AFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALL-HYDFRVVCLAAAA 183
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLaAFGWRAAFLILGL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 184 CFAVNFLVALRLpqvrmpdrppplrhgldlvrgnrAFIVLVGLMMLYWFVAVQINisfPLLAQRLTGTVDSVGVMFALSA 263
Cdd:COG2271 173 PGLLLALLRFWL-----------------------LALAYFLVYFALYGFLTWLP---TYLVEVRGLSLAQAGLLLSLPF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 264 GLTVALQYgLVRWLERRWSSAQ--VLVAGVVVMSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLADPRAL 341
Cdd:COG2271 227 LAGIVGSL-LGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKAR 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 951710016 342 GTFLGVSSLSLAVGGGIGNIAGGWMVDLAATkQWPWLPWAVFCVVGLASAFGLHQATR 399
Cdd:COG2271 306 GTASGLVNTFGFLGGALGPLLVGYLLDATGY-QAAFLLLAALALLAALLALLLLRETR 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-403 |
2.41e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 67.98 E-value: 2.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 17 AARRRGLHGLLVYTFLMVTGFaMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLL 96
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVW-YLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 97 RAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALLH-YDFR 175
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 176 VVCLAAAACFAVNFLVALRL----PQVRMPDRPPPLRHGLDLVRgNRAFIVLVGLMMLYWFVAVQINISFPLLAQRLTGT 251
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFlrdpPAGAAAAAKASLRDQLEALR-DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 252 VDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVR-DFAGLLICVGAFSIGALMTRPTQQT 330
Cdd:COG2223 239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFA 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 951710016 331 LIAGLADPRALGTFLGVSSLSLAVGGGIGNIAGGWMVDLAATKQWPWLPWAVFCVVGLASAFGLHQATRVRRE 403
Cdd:COG2223 319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
68-354 |
1.88e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 64.87 E-value: 1.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 68 LTQQGLALVGGVLSDRYGAR-RMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPR 146
Cdd:cd17370 45 ALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 147 YYAISNWISGVATTLGPLLGVALL---HYDFRVVCLAAA--ACFAVNFLVALRLPQVRmPDRPPPLRHGLDLVRGNRAFI 221
Cdd:cd17370 125 AFGLHRALDTLGAVLGPLLAALLLyllGGNYRTIFLLAAipALLALLILLFVVKEYPR-PPKLRKKSKKTSLKKLPKAFW 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 222 VLVGLMMLYWFVavqiNISFPLL---AQRLTGTVDSVGVMFALSAGLTVALQYgLVRWLERRWSSAQVLVAGVVVMSLAA 298
Cdd:cd17370 204 LYLLAVALFALG----NFSFAFLilrAQELGLSAALIPLLYALFNLVYALAAY-PAGRLSDRIGRKKLLILGYLSLALAY 278
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 951710016 299 GAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLADPRALGTFLGVSSLSLAV 354
Cdd:cd17370 279 LGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGI 334
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
74-321 |
3.86e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.10 E-value: 3.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRyYAISNW 153
Cdd:COG0738 60 SLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHA 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 154 ISGVATTLGPLLGVALLHYDF----RVVCLAAAACFAVNFLVALR--LPQVRM-PDRPPPLRHGLDLVRGNRAFIVLVGL 226
Cdd:COG0738 139 FFSLGALLGPLLGGLLILLGLslswHLPYLILAVLLLLLALLFLRskLPEIEEeEEEAAGSAASLKSLLKNPRLLLGGLA 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 227 MMLYWFVAVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRD 306
Cdd:COG0738 219 IFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPG 298
|
250
....*....|....*
gi 951710016 307 FAGLLICVGAFSIGA 321
Cdd:COG0738 299 PWLALIGLALVGLGL 313
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
78-317 |
1.13e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.57 E-value: 1.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 78 GVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEaPYQASIAALTDENTRPRYYAISNWISGV 157
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFH-PEGARLASQAAGGRRGLAMSIFSVGGNL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 158 ATTLGPLLGVALL----HYDFRVVCLAAAACFAVNFLVALRLPQVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLYWFV 233
Cdd:cd17478 131 GFALGPLIAAALValfgGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWV 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 234 AVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYgLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDFA--GLL 311
Cdd:cd17478 211 LSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTL-IGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWsyILL 289
|
....*.
gi 951710016 312 ICVGAF 317
Cdd:cd17478 290 VLAGFL 295
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
26-349 |
1.68e-10 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 61.86 E-value: 1.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 26 LLVYTFLMVTGFAMLMPLVAVHfVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLA 105
Cdd:cd17390 1 LYLVGFLDLFGVSMILPLLSTH-IRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 106 FADALPMLLCA-MLLSALGGAMFEApyQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALLHYD--FRVVCLAAA 182
Cdd:cd17390 80 FSTSLALLFLSrIPLGIFKHTQSLC--KAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDggFYYVALLCS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 183 ACFAVNF-LVALRLPQVRmpdrppplrhGLDLVRGNRAFIVLV-----GLMMLYWFvavqinisfpLLAQRLTGTVDSVG 256
Cdd:cd17390 158 AIFILNAgLVWFLLSKLW----------DLLLVRFLMGFSVLLfrsnfSLYLEERF----------DLSPKTIGYLISYS 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 257 VMFALSAGLTValqyGLVRWLERRwSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLA 336
Cdd:cd17390 218 GVLGALSGFLV----GRILKLYKN-NEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRG 292
|
330
....*....|...
gi 951710016 337 DPRALGTFLGVSS 349
Cdd:cd17390 293 KSKERGTLLGVGQ 305
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
74-352 |
4.93e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.66 E-value: 4.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNW 153
Cdd:cd17473 52 APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 154 ISGVATTLGPLLGVALLHYDFRVVCLAAAACFAVNFLVALRLPQVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLYWFV 233
Cdd:cd17473 132 AMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAML 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 234 A---VQINISFpLLAQRLTGTVDSVGVMFALsAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDFAGL 310
Cdd:cd17473 212 LfyvIPIQLPF-LLQERGGGSAALIGLALAI-ASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVV 289
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 951710016 311 LICVGAFSIGALMTRPTQQTLIAGLADPRALGTFLGVSSLSL 352
Cdd:cd17473 290 LLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF 331
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
73-354 |
1.28e-09 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 59.51 E-value: 1.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 73 LALVGGVLSDRY-GARRMICLGVLLRAAGFASLAFAD-ALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPR---- 146
Cdd:cd17346 56 TPIIGGWLADKVlGARRTVFIGGILMALGYLLLALSPfSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPRRdsgf 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 147 --YYAISNwisgVATTLGPLL-GVALLHYDFRVVCLAAAACFAVNFLVALrlpqvrmpdrpppLRHGLDLVRG-NRAFIV 222
Cdd:cd17346 136 siFYMGIN----LGAFLAPLLcGTLGDNYGYHYGFGLAAVGMLLGLLIFL-------------LGRKKLLERKkMLAIII 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 223 LVGLMMLYWFVAVQINISFPLLAQRLT-----GTVDSVGVMFALSAGLTVALQYGLVR---WLERR---WSSAQVLVAGV 291
Cdd:cd17346 199 LFLFAVVFWAIYEQAGTSLALFADENVdrllgGFTIPPSWFQSLNPLFIILLAPILAAlwtKLGKRgkdPSIPTKFALGL 278
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951710016 292 VVMSLAAGAIGLVRDFAG--------LLICVGAF-SIGALMTRPTQQTLIAGLADPRALGTFLGVSSLSLAV 354
Cdd:cd17346 279 LLLGLSFLLMVLAASFAGgsgkvsalWLVLSYFLqTLGELCLSPVGLSMITKLAPAKFAGFMMGLWFLASAL 350
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
68-351 |
1.62e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 59.15 E-value: 1.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 68 LTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLS---ALGGAMFeapyqASIAALTDENTR 144
Cdd:cd17472 43 LTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQgsgAISSVVM-----ALLADLTREENR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 145 PRYYAISNWISGVATTLGPLLGVAL-LHYDFRVVCLAAAACFAVNFLVALRLpqvrMPDRPPPLRHGLDL------VRGN 217
Cdd:cd17472 118 TKAMALIGASIGIAFAISMVLGPLLaAHLGVSGLFLITAILSLVSLLILLFF----VPDPPKIVQISEKEkkklkkLLKN 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 218 RAFIVLVGLMMLYWFVAVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLA 297
Cdd:cd17472 194 KRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVG 273
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 951710016 298 -AGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLADPRALGTFLGVSSLS 351
Cdd:cd17472 274 fLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTS 328
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
72-302 |
2.52e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.90 E-value: 2.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 72 GLALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAIS 151
Cdd:COG0477 64 IGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLW 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 152 NWISGVATTLGPLLGVALL-HYDFRVVCLAAAACFAVNFLVALRLPQVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLY 230
Cdd:COG0477 144 GAAIGLGLALGPLLGGLLVaALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLL 223
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951710016 231 WFVAVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIG 302
Cdd:COG0477 224 LLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
78-392 |
5.25e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 57.67 E-value: 5.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 78 GVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGG-AMFEAPYQASIAALTDENTRPRYYAISNWISG 156
Cdd:cd17355 59 GRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGaGTLAAVAFATVAAWWFERRRGLALGILTAGGG 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 157 VATTLGPLLGVALL-HYDFRVVCLAAAACFAVNFLVALRLPQVRMPDRPPPLRHGLDLVR---------GNRAFIVLVGL 226
Cdd:cd17355 139 LGSLVFLPLGAALIeAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASpgstlkealRSASFWLLALA 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 227 MMLYWFVAVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYgLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVR- 305
Cdd:cd17355 219 FFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRL-LSGWLGDRYSPRRLLAASYALRALGLALLLLLPf 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 306 DFAGLLICVGAFSIGALMTRPTQQTLIAGLADPRALGTFLGVSSLSLAVGGGIGNIAGGWMVDLAATKQWPWLPWAVFCV 385
Cdd:cd17355 298 PPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGL 377
|
....*..
gi 951710016 386 VGLASAF 392
Cdd:cd17355 378 IAALLVL 384
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
26-354 |
2.71e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 2.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 26 LLVYTFLMVTGFAMLMPLVAVhFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLA 105
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPL-YAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 106 FADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPR---YYAISNwisGVATTLGPLLGVALL-HYDFRVVCLAA 181
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEgigYYGLAT---TLAMALGPALGLFLYqHLGFAVLFIVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 182 AACFAVNFLVALRLPQVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLYWFVAVQINISF-PLLAQrlTGTVDSVGVMFA 260
Cdd:cd17489 157 AVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFlPLYAA--ERGISNAGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 261 LSAGLTVALQYgLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLADPRA 340
Cdd:cd17489 235 VYAIALLLSRP-FSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHR 313
|
330
....*....|....
gi 951710016 341 LGTFLGVSSLSLAV 354
Cdd:cd17489 314 RGAANGTFFIFFDL 327
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
74-324 |
3.95e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 54.87 E-value: 3.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNW 153
Cdd:cd17477 48 SPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYST 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 154 ISGVATTLGPLLGVALLHYDFRVVCLAAAACFAVNFLVALrlpqVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLYWFV 233
Cdd:cd17477 128 VLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLL----TRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 234 AVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYgLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLIC 313
Cdd:cd17477 204 EGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQW-PLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLV 282
|
250
....*....|.
gi 951710016 314 VGAFSIGALMT 324
Cdd:cd17477 283 LLFLWGGAAGP 293
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
75-324 |
4.11e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 54.89 E-value: 4.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 75 LVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWI 154
Cdd:cd17320 52 LLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMI 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 155 SGVATTLGPLLGVALL-----HYDFRVVCLAAAACFavnFLVALRLPQVRMPDR----PPPLRHGLDLVRGNRAFI---V 222
Cdd:cd17320 132 LAIAPALAPLLGGLLLlffgwRAIFVFLALLGLLLL---LLVLLFLPETLPEEKrkplLSSLLRAYKRVLKNRRFLgyaL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 223 LVGLMMLYWFvaVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYgLVRWLERRWSSAQVL-------VAGVVVMS 295
Cdd:cd17320 209 ALGLSFAGLF--AYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSL-LNGRLVRRFGPRRLLrlgllllLAAALVLL 285
|
250 260
....*....|....*....|....*....
gi 951710016 296 LAAGAIGLVRDFAGLLICVGAFSIGALMT 324
Cdd:cd17320 286 LAALLGGLSLWPLVAPLFLIFFGFGLIFP 314
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
74-193 |
5.24e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.39 E-value: 5.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNW 153
Cdd:cd17370 251 AYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNT 330
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 951710016 154 ISGVATTLGPLLGVALLHYDFRVVCLAAAACFAVNFLVAL 193
Cdd:cd17370 331 VVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-161 |
5.32e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.13 E-value: 5.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 10 EGATLSEAARRRGLHGLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRM 89
Cdd:COG2814 196 LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL 275
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951710016 90 ICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTL 161
Cdd:COG2814 276 LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
73-267 |
7.14e-07 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 50.97 E-value: 7.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 73 LALVGGVLSDRY-GARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPR----- 146
Cdd:COG3104 71 TPLLGGWLADRLlGQRRAILLGGILMALGHFLLALPGGVTLFYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRdagft 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 147 -YYAISNwisgVATTLGPLL-GVALLHYDFRVVCLAAAACFA---VNFLVALR-LPQVRM-PDRPPPLRHGLDLVRGNRA 219
Cdd:COG3104 151 iFYMGIN----IGAFLAPLLcGYLGEKYGWHYGFGAAAIGMLiglIIFLLGRKyLGDIGLePDNPLSKKERLIAVALGAL 226
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 951710016 220 FIVLVGLMML---------YWFVAVQINISFPLLAQRLTGTV-DSVGVMFALSAGLTV 267
Cdd:COG3104 227 LLVLVLAGLLsnanianylLYVIAIIAYFIFILRSKKLTKEErKRLLAILILFLFSIV 284
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
72-172 |
1.58e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.86 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 72 GLALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAIS 151
Cdd:cd17321 46 ALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLW 125
|
90 100
....*....|....*....|.
gi 951710016 152 NWISGVATTLGPLLGVALLHY 172
Cdd:cd17321 126 GAVVGIGAALGPLLGGLLLEL 146
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
31-312 |
3.96e-06 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 48.73 E-value: 3.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 31 FLMVTGFAMLMPLVAVHFvNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICL-GVLLRAAGFASLAF-AD 108
Cdd:cd17335 7 FFFFAALGSLLPFLSVYL-KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLlSLLAAVLFFLSLFFvAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 109 ALPMLLCAMLLsalgGAMFEAPY-----QASIAALTDENT---RPRYYAISNWISGVATTlGPLLGVALLHYDFRVVCLA 180
Cdd:cd17335 86 IFWLLLLLVIL----GAFFSAPVvplvdSITLQYLGEERErygKQRLWGSIGFGIAALLV-GILIDRSSTYKNYTIAFYV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 181 AAACFAVNFLVALRLPqVRMPDRPPP--LRHGLDLVRGNRAFIVLVGLMMLYWFVAVQINISFPLLaQRLTGTVDSVGVM 258
Cdd:cd17335 161 FAVLMLLALLLALKFP-FRPKHPEPNenTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHL-QDLGGSKTLIGLL 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 951710016 259 FALSAGLTVALQYGLVRWLeRRWSSAQVLVAGVVVMSLAAGAIGLVRDFAGLLI 312
Cdd:cd17335 239 WTVGVVSEIPFFFFSSRLI-QRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLP 291
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
74-195 |
9.22e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 9.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNW 153
Cdd:cd06173 261 ALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNA 340
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 951710016 154 ISGVATTLGPLL-GVALLHYDFRVVCLAAAACFAVNFLVALRL 195
Cdd:cd06173 341 LNSGAMPLGALLaGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
68-267 |
9.23e-06 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 47.80 E-value: 9.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 68 LTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASI-AALTDEntRPR 146
Cdd:PRK14995 52 LVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIrATFTEE--KQR 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 147 YYAISNW--ISGVATTLGPLLGVALL-HYDFRVVCLAAAACFAVNFLVALRL--PQVRMPDRPPPLRHGL---------- 211
Cdd:PRK14995 130 NMALGVWaaVGSGGAAFGPLVGGILLeHFYWGSVFLINVPIVLVVMGLTARYvpRQAGRRDQPLNLGHALmlivailllv 209
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 951710016 212 ---------DLVRGNRAFIVLVGLMMLYWFVAVQINISFPLLAQRL-TGTVDSVGVMFALSAGLTV 267
Cdd:PRK14995 210 ysaktalkgFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLfTHRIILSGVVMAMTAMITL 275
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-170 |
9.31e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.59 E-value: 9.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 12 ATLSEAARRRGLHGLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMIC 91
Cdd:COG2211 219 ESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFI 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 92 LGVLLRAAGFASLAFADA--LPMLLCAMLLSALGGAMFEAPYQASIAALTD-------ENTRPRYYAISNWISGVATTLG 162
Cdd:COG2211 299 IGLLLAALGLLLLFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALA 378
|
....*...
gi 951710016 163 PLLGVALL 170
Cdd:COG2211 379 GALAGLLL 386
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
74-352 |
9.80e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.16 E-value: 9.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRyyAISNW 153
Cdd:cd17324 51 ALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGR--AIGLV 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 154 ISGvaTTLGPLLGVAL-----LHYDFRVVCLAAAAC-FAVNFLVALRLPQVR-MPDRPPPLRHGLDLVRGNRAFIVLVGL 226
Cdd:cd17324 129 FSG--LTLGLVLGRPLggllgQLLGWRAAFLAIAVLaLLAALLLWRLLPSLPpKKPGSLGLLSSLLLLLRNPRLRLAYLI 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 227 MMLYWFVAVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRD 306
Cdd:cd17324 207 TFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPS 286
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 951710016 307 FAGLLICVGAFSIGALMTRPTQQTLIAGLAdPRALGTFLGVSSLSL 352
Cdd:cd17324 287 PLLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAY 331
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
74-389 |
9.82e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.23 E-value: 9.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPryYAISnw 153
Cdd:cd17475 48 MLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERG--LAMG-- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 154 ISGVATTLGPLLGVALL-----HYDFRVVCLAAAAC---FAVNFLVALRLPQV--RMPDRPPPLRHGLDLVRGNRAF--I 221
Cdd:cd17475 124 IRQTGVPLGGALAAALLpplalHYGWRAAFVVAGLVsilAAVLFWLFYREPPAasAATESASTLLRSLKEVLRNRDVwlI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 222 VLVGLMMlywfVAVQINISF---PLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWS---------SAQVLVA 289
Cdd:cd17475 204 AIAGALL----VAPQFALLTfllLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrpvlviTAAIAAA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 290 GVVVMSLAAGAIGLVRDFAgLLICVGAFSIGalmTRPTQQTLIAGLADPRALGTFLGVSSLSLAVGGGIGNIAGGWMVDL 369
Cdd:cd17475 280 ALLVLSLLSPGTPLWLLVL-LLILLGLFAIG---WNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDA 355
|
330 340
....*....|....*....|
gi 951710016 370 AATKQWPWLPWAVFCVVGLA 389
Cdd:cd17475 356 THSYAPAWLALALLLVLAAL 375
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
72-348 |
1.37e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.83 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 72 GLALVGGVL----SDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEApyQASIAALTDENTRPRY 147
Cdd:cd17331 46 VLQLVGGPLfgrfGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAMQAA--QMVVTDLTDPGERAAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 148 YAISNWISGVATTLGPLLGVALL-HYDFRVVCL-AAAACFAVNFLVALRLP-QVRMPDRPPPLRHGLDLVRGNRAFIVLV 224
Cdd:cd17331 124 LGRLGLSYGIGMVVGSFLGGLLTkKFGEQAAALvAAVGSLLSIVLVILLIPsNTKSKREKEAKESASPPSVFNLKEILRL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 225 -------GLMMLYWFVAVQINI---SFPLLA-QRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVV 293
Cdd:cd17331 204 lrlpgvaFLLLVKLLSGLPIGMfqsMFSLVAmDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVAL 283
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 951710016 294 MSLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLADPRALGTFLGVS 348
Cdd:cd17331 284 LAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLS 338
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
69-213 |
2.60e-05 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 45.85 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 69 TQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPML-LCAMLLSALGGAMFEAPyqaSIAALTDENTRPRY 147
Cdd:cd17423 50 VQQLASPVGSALSTRYGARPVVMLGGLLSSLGFLLASFATSLLHLyLCIGLLSGLGWALVFAP---TMATVSRYFSRRRS 126
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951710016 148 YAISNWISGVAT---TLGPLLGVALLHYDFRVVCLAAAAcFAVNFLV--ALRLPQVRMPDRPPPLRHGLDL 213
Cdd:cd17423 127 LATGLALTGVGLssfALSPLFQLLLDTYAWRGALLLLSA-LSLHLVPcgALLRPLALPGDPPAPPRSLSAA 196
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
17-170 |
7.13e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 7.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 17 AARRRGLHGLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICLGVLL 96
Cdd:cd17329 196 VLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILL 275
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 951710016 97 RAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALL 170
Cdd:cd17329 276 FAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLL 349
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
75-350 |
8.70e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.19 E-value: 8.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 75 LVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWI 154
Cdd:cd17312 56 FISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 155 SGVATTLGPLL-GVALLHYDFRVVCLAAAACFAVNFLVALRLpqvrMPDRPPPLRHgLDLVrgnRAFIVLVGLMMLYWFV 233
Cdd:cd17312 136 HNFGGILAPILaASLASYYGWRAAFLVPGIVGLVVAIILFFF----LRDSPPYVWV-LSLA---YAFVYIVRYACLDWGP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 234 avqinisFPLLAQRLTGTVDSVGVMFALS-AGLTVALQYGlvrWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDFAG--L 310
Cdd:cd17312 208 -------LYLYEVKGYSLIDAGWFSSLYEvGGIAGTILAG---LLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHnkL 277
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 951710016 311 LICVGAFSIGALMTRPtqQTLIAGLADPR-----ALGTFLGVSSL 350
Cdd:cd17312 278 LSIVLLFLIGFFVGGP--INLIGGAAAQDigrkeAAGTATGFVGL 320
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-193 |
8.95e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.34 E-value: 8.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 14 LSEAARRRGLHGLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMICL- 92
Cdd:cd06174 196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLi 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 93 GVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLLGVALL-- 170
Cdd:cd06174 276 GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaa 355
|
170 180
....*....|....*....|...
gi 951710016 171 HYDFRVVCLAAAACFAVNFLVAL 193
Cdd:cd06174 356 TFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
75-172 |
1.39e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 43.72 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 75 LVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWI 154
Cdd:cd17323 52 LIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLG 131
|
90
....*....|....*...
gi 951710016 155 SGVATTLGPLLGVALLHY 172
Cdd:cd17323 132 PLLGPALGPIIGGFITQS 149
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
68-169 |
1.53e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 43.32 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 68 LTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRY 147
Cdd:cd17502 41 LTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKY 120
|
90 100
....*....|....*....|..
gi 951710016 148 YAISNWISGVATTLGPLLGVAL 169
Cdd:cd17502 121 QGYIGAVFGIASVAGPLIGGAF 142
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
12-206 |
1.57e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.72 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 12 ATLSEAARRRGLHGLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARRMIC 91
Cdd:COG2223 196 RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 92 LGVLLRAAGFASLAFA-DALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGPLL-GVAL 169
Cdd:COG2223 276 IVFALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLfGALL 355
|
170 180 190
....*....|....*....|....*....|....*..
gi 951710016 170 LHYDFRVVCLAAAACFAVNFLVALRLPQVRMPDRPPP 206
Cdd:COG2223 356 DATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
73-351 |
1.61e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 43.34 E-value: 1.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 73 LALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFeapyQASIAALTDENTRPRYYAISN 152
Cdd:cd17504 47 STPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF----PLAFALVREEFPPERVPVAQG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 153 WIS---GVATTLGPLLGVALL-HYDFRVVCLAAAACFAVNFLVAlrlPQVRmpdrppplrhgLDLVRgNRAFIVLVGLMM 228
Cdd:cd17504 123 ILSatfGIGAGIGLPLGGWIVqHLGWRWIFWTAAPVAVLLAALV---PLID-----------LRLLR-RRNVLLANITAL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 229 LYWFVAVQINISFPLLAQRLTGTVDSVGVMFA----LSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLV 304
Cdd:cd17504 188 LAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAglllLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALL 267
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 951710016 305 RD-FAGLLICVGAFSIGALMTRPTQQTLIAGLADPRALGTFLGVSSLS 351
Cdd:cd17504 268 HSsLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVL 315
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
75-334 |
2.02e-04 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 43.43 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 75 LVGGVLSDRYGARRMICLGVLLRAAGFASLAFADAL--PMLLCAMLLSA---LGGAMFEAPYQASIAALTDENTRPRYYA 149
Cdd:PRK10489 70 MVGGVLADRYDRKKLILLARGTCGLGFIGLALNAFLpePSLLAIYLLGLwdgFFGSLGVTALLAATPALVGRENLMQAGA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 150 ISNWISGVATTLGPLLGVALL-------HYdfrvvCLAAAACFAVNFLVaLRLPQVRMPDRPP--PLRH---GLDLVRGN 217
Cdd:PRK10489 150 ITMLTVRLGSVISPALGGLLIaaggvawNY-----GLAAAGTFITLLPL-LRLPALPPPPQPRehPLRSllaGFRFLLAS 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 218 RAF--IVLVGLMMLywfVAVQINISFPLLA-QRLTGTVDSVGVMFALSAgLTVALQYGLVRWLERRWSSAQVLVAGVVVM 294
Cdd:PRK10489 224 PVVggIALLGGLLT---MASAVRVLYPALAdEVWQMGAAQIGLLYAAVP-LGAALGALTSGWLAHSARPGLLMLLSTLGS 299
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 951710016 295 SLAAGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAG 334
Cdd:PRK10489 300 FLAVGLFGLMPMWILAVLCLALFGYLSAISSLLQYTLLQT 339
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
73-394 |
2.59e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.94 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 73 LALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENtRPRYYAISN 152
Cdd:COG2807 69 FAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYT 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 153 WISGVATTLGPLLGVALL-HYDFRVVcLAAAACFAVNFLVALRLPQVRMPDRPPPLRHGLDLVR--GNRAFIVLVGLMML 229
Cdd:COG2807 148 AAMGLGAALAAGLTVPLAaALGWRGA-LAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSlwRSPLAWLLTLFFGL 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 230 YWFVAVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDFAG 309
Cdd:COG2807 227 QSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLP 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 310 LLICVgAFSIGALMTRPTQQTLIAGLA-DPRALGTFLGVSSLSLAVGGGIGNIAGGWMVDLAATKQWPWLPWAVFCVVGL 388
Cdd:COG2807 307 WLWAV-LLGLGQGGLFPLALTLIGLRArTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLML 385
|
....*.
gi 951710016 389 ASAFGL 394
Cdd:COG2807 386 VAGLLA 391
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
74-197 |
3.38e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 42.99 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNW 153
Cdd:PRK08633 286 SLLAGRLSGRHIELGLVPLGALGLALSLFLLPTAPSLASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKVLAANNF 365
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 951710016 154 ISGVATTLGPLLGVALLHYDFRVVCL---AAAACFAVNFLVALRLPQ 197
Cdd:PRK08633 366 LQNVGMLLFLALTTLFSGLGLSPAGLfylIALVTLIGTLYTLLLLPD 412
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
74-323 |
4.49e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.92 E-value: 4.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTdENTRPRYYAISNW 153
Cdd:cd17333 48 SLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 154 ISGVATTLGPLLGVALLHYDFrVVCLAAAACFAVNFLVALRLPQVRMPDRPP-------PLRHGLDLVRGNRAFIVLVGL 226
Cdd:cd17333 127 FFGLGALIGPLIATSLLTSEL-SWSWAYLIIGLIYLLLAILILLTLFPELPSarnpqqsVGAFSASASRLLRNPSIILGA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 227 MMLYWFVAVQINIS--FPLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAIGLV 304
Cdd:cd17333 206 LALFLYVGAETAFSswVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLA 285
|
250
....*....|....*....
gi 951710016 305 RDFAGLLicVGAFSIGALM 323
Cdd:cd17333 286 PTLVVGL--VATALLGLFM 302
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
75-394 |
5.59e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 5.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 75 LVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFeapYQASIAALTD---ENTRPRYYAIS 151
Cdd:cd17319 56 VPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGF---FPGAIKALAEwfpARERGRATGLF 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 152 NWISGVATTLGPLLGVALL-HYDFRVV--CLAAAACFAVnFLVALRLPQVrmpdrppplrHGLDLVRgnrAFIVLVGLMM 228
Cdd:cd17319 133 NSGAPLGAAIGPPLSGWLLlLFGWRWAfiIEGLLGLLLA-VLWWFYLRQV----------WGLALGY---FGINYALYGL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 229 LYWFvavqinisFPLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLER--RWSSAQVLVAGVVVMSLAAGAIGLVRD 306
Cdd:cd17319 199 LTWL--------PTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTS 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 307 FAGLLICVGAFSIGALMTRPTQQTLIAGLADPRALGTFLGVSSLSLAVGGGIGNIAGGWMVDLAATKQWPWLPWAVFCVV 386
Cdd:cd17319 271 PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALL 350
|
....*...
gi 951710016 387 GLASAFGL 394
Cdd:cd17319 351 AALLVLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-163 |
6.64e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.63 E-value: 6.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 20 RRGLHGLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDRYGARR---MICLGVLL 96
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLIL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 951710016 97 RAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGVATTLGP 163
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
71-193 |
7.09e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.38 E-value: 7.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 71 QGLALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAM-LLSALGGAMFeapYQASIAALTD--ENTRPRY 147
Cdd:cd17352 52 LFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYgVLGGLGLGLI---YSPAIVIVGQyfEKKRGLA 128
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 951710016 148 YAISNWISGVATTL-GPLLGVALLHYDFRVVCLAAAACFAVNFLVAL 193
Cdd:cd17352 129 TGIAVAGSGVGTFVfPPLLRYLLDNYGWRGALLILGGLCLNLCVCGL 175
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
4-193 |
7.75e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.38 E-value: 7.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 4 TSVAIDEGATLSEAARRRGLHGLLVYTFLMVTGFAMLMPLVAVHFVNDLGMAAAAVGLALAVRQLTQQGLALVGGVLSDR 83
Cdd:cd17324 181 KPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 84 YGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENtRPRYYAISNWISGVATTLGP 163
Cdd:cd17324 261 GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGA 339
|
170 180 190
....*....|....*....|....*....|.
gi 951710016 164 LL-GVALLHYDFRVVCLAAAACFAVNFLVAL 193
Cdd:cd17324 340 ALgGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
78-194 |
9.66e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.10 E-value: 9.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 78 GVLSDRYGARRMICLGVLLRAAGFASLAFA-DALPMLLCAMLLSALGGAMFEApYQASIAALTDENTRPRYYAISNWISG 156
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVqTPWQLGILRFLLGLATGGLLPA-INSLLAKITPKEVAGRIFGYNQSFQY 339
|
90 100 110
....*....|....*....|....*....|....*....
gi 951710016 157 VATTLGPLLGVAL-LHYDFRVVCLAAAACFAVNFLVALR 194
Cdd:cd17391 340 LGNVAGPLLGSAIaAHFGYRAVFVVTALLVLLNAIWSFI 378
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
75-211 |
1.03e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 40.82 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 75 LVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWI 154
Cdd:TIGR00881 48 FVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCS 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 155 SGVATTLGP---LLGVAlLHYDFRVVCLAAAACFAVNFLVALRLPqvrmpdRPPPLRHGL 211
Cdd:TIGR00881 128 HNVGGGLLPplvLFGIA-ELYSWHWVFIVPGIIAIIVSLICFLLL------RDSPQSCGL 180
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
68-125 |
1.16e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.67 E-value: 1.16e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 951710016 68 LTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLcaMLLSALGGA 125
Cdd:cd17353 49 VFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLF--LGYGVLGGI 104
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
75-327 |
1.21e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 40.70 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 75 LVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALtDENTRPRYYAISNWI 154
Cdd:cd17393 52 PLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFGAANGALDVAMNAQGVAV-ERAYGRPIMSSLHAM 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 155 SGVATTLGPLLGVALLHYDF--RVVCLAAAACFAVNFLVALR--LPQVRMPDRPPPLRHGLDLVRGNRAFIVLVGLMMLY 230
Cdd:cd17393 131 WSLGGLAGALLGAAAIGAGVspGVHLLAAAVLLLLAALVAIRalLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 231 WFVAVQINISF-PLLAQRLTGTVDSVGVM--FALSAGLTVALQYGlvRWLERRWSSAQVLVAGVVVMSLAAGAIGLVRDF 307
Cdd:cd17393 211 AALAEGAAADWsALYLRDVLGASAALAALgyAVFSLAMTVGRLFG--DRLVDRFGDVAVLRAGALLAALGLLLALLAPSV 288
|
250 260
....*....|....*....|
gi 951710016 308 AGLLICVGAFSIGALMTRPT 327
Cdd:cd17393 289 WVALAGFALMGLGLSVVVPL 308
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
74-194 |
1.41e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.67 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNW 153
Cdd:cd17331 261 GLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHA 340
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 951710016 154 ISGVATTLGPLLGVALL-HYDFRVVCLAAAACFAVNFLVALR 194
Cdd:cd17331 341 LFSLVRTVSPTIGGALLqAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
73-353 |
1.43e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 40.89 E-value: 1.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 73 LALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPM-----LLCAMLLSALGGAMFEAPYQASIAALTDENTRPRY 147
Cdd:pfam05977 61 LSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLlspwlLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAA 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 148 YAISNWISGVATTLGPLLGVALLH-YDFRVVCLAAAACFAVNFLVALRLPQVRMPDRPPP------LRHGLDLVRGNRAF 220
Cdd:pfam05977 141 VALNSVGYNIARSVGPALGGVLLAaFGPAFTFALNALSYFAVIAALWRWKRAAPASPLPRerifgaVRAGLRFTAMSREL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 221 IVLVGLMMLYWFVAVQINISFPLLAQRLTGTVDSV-GVMFAlSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAG 299
Cdd:pfam05977 221 RSVLVRAFAFGLSASAVWALLPLVARDLLDGDAIFyGILLG-AVGVGAILGALSLPRLRERLGSDRLVLLASVVTALVLL 299
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 951710016 300 AIGLVRDFAGL---LICVGAFSIGALMT-RPTQQTLIAGLADPRALGTFLGVSSLSLA 353
Cdd:pfam05977 300 SLALAPNLWLAipvLLLGGAAWITALTTlNVAVQLSVPRWVRGRALAVYQTVFFGGMA 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
218-406 |
2.36e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.96 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 218 RAFIVLVGLMMLYWFVAVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYgLVRWLERRWSSAQVLVAGVVVMSLA 297
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAP-LAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 298 AGAIGLVRDFAGLLICVGAFSIGALMTRPTQQTLIAGLADPRALGTFLGVSSLSLAVGGGIGNIAGGWMVDLAATKQWPW 377
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180
....*....|....*....|....*....
gi 951710016 378 LPWAVFCVVGLASAFGLHQATRVRRERAP 406
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLR 197
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
75-195 |
2.80e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 75 LVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRyyAISNWI 154
Cdd:cd17489 245 PFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA--ANGTFF 322
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 951710016 155 SGVATTLG---PLLGVALLHYDFRVVCLAAAACFAVNFLVALRL 195
Cdd:cd17489 323 IFFDLGIGlggLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
73-195 |
3.46e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.53 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 73 LALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISN 152
Cdd:cd17328 50 LSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFY 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 951710016 153 WISGVATTLGPLLG--VALLHYDFRvVCLAAAACFAVNFLVALRL 195
Cdd:cd17328 130 FAIPLGSGLGYVVGglVAQATGGWR-WAFRVTGVLGVLLAILLLL 173
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
78-301 |
4.23e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 4.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 78 GVLSDRYGARRM-ICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFeAPYQASIAALTDENTRPRYYAISNWISG 156
Cdd:cd17490 52 GILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATW-VSFTVLYASYFPPDEAAKAMGLINLVNN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 157 VATTLGPLL-GVALLHYDFRVVCLAAAACFAVNFLVALRLPQVRMPDRP--PPLRHGLDLVRgNRAFIVLVGLMMLYWFV 233
Cdd:cd17490 131 LGQLIAFLIgGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPvlTELKELLSVLK-DKKLLFFSLLAILQQMI 209
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 951710016 234 AVQINISF-PLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLAAGAI 301
Cdd:cd17490 210 TFSTTFGFtPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLI 278
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
75-203 |
6.24e-03 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 38.52 E-value: 6.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 75 LVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAmfeAPYQASIAALTDENTR---PRYYAIS 151
Cdd:TIGR00710 58 LLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGAS---AGSVISQALVRDIYPGeelSRIYSIL 134
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 951710016 152 NWISGVATTLGPLLGVALL-----HYDFRVVCLAAAACFAvnfLVALRLPQVRMPDR 203
Cdd:TIGR00710 135 MPVLALAPAVAPLLGGYILvwlswHAIFAFLSLAGILLSA---LIFFILPETLPYEA 188
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
68-170 |
6.75e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 38.76 E-value: 6.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 68 LTQQGLALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMfEAPYQASIAALTDENTRPRY 147
Cdd:cd06179 43 LAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLV 121
|
90 100
....*....|....*....|...
gi 951710016 148 YAISNWISGVATTLGPLLGVALL 170
Cdd:cd06179 122 QGVVNLVASPGSALGPLIAGALV 144
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
74-198 |
7.58e-03 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 38.17 E-value: 7.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 74 ALVGGVLSDRYGARRMICLGVLLRAAGFASLAFADALPM-----LLCAMLLSALGgamfeapyqASIAALTDENTRPRYY 148
Cdd:cd17446 50 AIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIycvfrFLTGMALSGIV---------LNSVSLNVEWMPTRVR 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 951710016 149 AISNWISGVATTLGPLL--GVALLHYDFRVVCLAAAACFAVNFLVALRLPQV 198
Cdd:cd17446 121 AVVGTLLGYCYTLGQLIlaGVAYAIRDWRWLQLAVSLPFFIFFLYSWWFPRI 172
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
78-297 |
8.60e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 37.94 E-value: 8.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 78 GVLSDRYGARRMICLGVLLRAAGFASLAFADALPMLLCAMLLSALGGAMFEAPYQASIAALTDENTRPRYYAISNWISGV 157
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951710016 158 ATTLGPLLGVALL-----HYDFRVVCLAAAACFAVNFLVALRLPQvrmpdrppplrhgldlvrgNRAFIVLVGLMMLYWF 232
Cdd:cd17503 132 APAIGPTLGGWLTdnlswRWIFYINLPIGILALLLAPLLDLRLFK-------------------DRNFTLGLLLSFLLGL 192
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 951710016 233 VAVQINISFPLLAQRLTGTVDSVGVMFALSAGLTVALQYGLVRWLERRWSSAQVLVAGVVVMSLA 297
Cdd:cd17503 193 GLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALG 257
|
|
| |
