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Conserved domains on  [gi|9506741|ref|NP_061833|]
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glycine N-methyltransferase isoform 1 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11454890)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 37-175 7.26e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 85.84  E-value: 7.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   37 DTRSRTAEYKAWLLGLLRQHGCQ--RVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlkerwnRRHEPAFDKWVIe 114
Cdd:COG2227   2 SDPDARDFWDRRLAALLARLLPAggRVLDVGCGTGRLALALARRGADVTGVDISPEALEIA------RERAAELNVDFV- 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9506741  115 EANWMTLDKdvpqsAEGGFDAVICLgNSFAHLPDckgdqseHRLALKNIASMVRAGGLLVI 175
Cdd:COG2227  75 QGDLEDLPL-----EDGSFDLVICS-EVLEHLPD-------PAALLRELARLLKPGGLLLL 122
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 37-175 7.26e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 85.84  E-value: 7.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   37 DTRSRTAEYKAWLLGLLRQHGCQ--RVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlkerwnRRHEPAFDKWVIe 114
Cdd:COG2227   2 SDPDARDFWDRRLAALLARLLPAggRVLDVGCGTGRLALALARRGADVTGVDISPEALEIA------RERAAELNVDFV- 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9506741  115 EANWMTLDKdvpqsAEGGFDAVICLgNSFAHLPDckgdqseHRLALKNIASMVRAGGLLVI 175
Cdd:COG2227  75 QGDLEDLPL-----EDGSFDLVICS-EVLEHLPD-------PAALLRELARLLKPGGLLLL 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 61-171 3.65e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 69.51  E-value: 3.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741     61 VLDVACGTGVDSIMLVEE-GFSVTSVDASDKMLKYAlkerwNRRHEPAFDKWVIEEANWMTLDKdvpqsAEGGFDAVICL 139
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERA-----RERAAEAGLNVEFVQGDAEDLPF-----PDGSFDLVVSS 70

                          90       100       110
                  ....*....|....*....|....*....|..
gi 9506741    140 GnSFAHLPDckgdqSEHRLALKNIASMVRAGG 171
Cdd:pfam13649  71 G-VLHHLPD-----PDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 60-175 1.94e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 59.75  E-value: 1.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   60 RVLDVACGTGVDSIMLVE-EGFSVTSVDASDKMLKYALKERWNRRHepafDKWVIEEANWMTLDKDVPQSaeggFDAVIC 138
Cdd:cd02440   1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLA----DNVEVLKGDAEELPPEADES----FDVIIS 72

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 9506741  139 lGNSFAHLPDckgdqsEHRLALKNIASMVRAGGLLVI 175
Cdd:cd02440  73 -DPPLHHLVE------DLARFLEEARRLLKPGGVLVL 102
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 22-168 6.77e-10

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 57.92  E-value: 6.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741    22 YADGEAARVwQLYIGDTRSRT-AEYKAWLLGLLRQHGCqRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlKERW 100
Cdd:PRK07580  29 YSDAPVSKV-RATVRAGHQRMrDTVLSWLPADGDLTGL-RILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEA-RERA 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9506741   101 NRRHEPafdkwviEEANWMTLDKDvpqSAEGGFDAVICLgNSFAHLPDCKGDQsehrlALKNIASMVR 168
Cdd:PRK07580 106 PEAGLA-------GNITFEVGDLE---SLLGRFDTVVCL-DVLIHYPQEDAAR-----MLAHLASLTR 157
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 59-175 7.26e-04

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 39.94  E-value: 7.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741     59 QRVLDVACGTGVDSIML---VEEGFSVTSVDASDKMLKYALKerwnrRHE-PAFDKWVIEEANWMTLDKDVpqsaeggFD 134
Cdd:TIGR01934  41 QKVLDVACGTGDLAIELaksAPDRGKVTGVDFSSEMLEVAKK-----KSElPLNIEFIQADAEALPFEDNS-------FD 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 9506741    135 AVIClgnSFAhLPDCkgdqSEHRLALKNIASMVRAGGLLVI 175
Cdd:TIGR01934 109 AVTI---AFG-LRNV----TDIQKALREMYRVLKPGGRLVI 141
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 37-175 7.26e-21

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 85.84  E-value: 7.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   37 DTRSRTAEYKAWLLGLLRQHGCQ--RVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlkerwnRRHEPAFDKWVIe 114
Cdd:COG2227   2 SDPDARDFWDRRLAALLARLLPAggRVLDVGCGTGRLALALARRGADVTGVDISPEALEIA------RERAAELNVDFV- 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9506741  115 EANWMTLDKdvpqsAEGGFDAVICLgNSFAHLPDckgdqseHRLALKNIASMVRAGGLLVI 175
Cdd:COG2227  75 QGDLEDLPL-----EDGSFDLVICS-EVLEHLPD-------PAALLRELARLLKPGGLLLL 122
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 37-175 3.97e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 76.19  E-value: 3.97e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   37 DTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlKERWNRRHEPAfdKWVIEEA 116
Cdd:COG2226   2 DRVAARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELA-RERAAEAGLNV--EFVVGDA 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 9506741  117 NWMTLdkdvpqsAEGGFDAVICLgNSFAHLPDckgdqseHRLALKNIASMVRAGGLLVI 175
Cdd:COG2226  79 EDLPF-------PDGSFDLVISS-FVLHHLPD-------PERALAEIARVLKPGGRLVV 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 61-171 3.65e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 69.51  E-value: 3.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741     61 VLDVACGTGVDSIMLVEE-GFSVTSVDASDKMLKYAlkerwNRRHEPAFDKWVIEEANWMTLDKdvpqsAEGGFDAVICL 139
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERA-----RERAAEAGLNVEFVQGDAEDLPF-----PDGSFDLVVSS 70

                          90       100       110
                  ....*....|....*....|....*....|..
gi 9506741    140 GnSFAHLPDckgdqSEHRLALKNIASMVRAGG 171
Cdd:pfam13649  71 G-VLHHLPD-----PDLEAALREIARVLKPGG 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 47-175 1.00e-13

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 67.26  E-value: 1.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   47 AWLLGLLRQHGCQRVLDVACGTGVDSIMLVEE-GFSVTSVDASDKMLKYAlkERWNRRHEPAfDKWVIEEANWMTLDkdv 125
Cdd:COG2230  41 DLILRKLGLKPGMRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYA--RERAAEAGLA-DRVEVRLADYRDLP--- 114

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 9506741  126 pqsAEGGFDAVICLGnSFAHLPDckgdqSEHRLALKNIASMVRAGGLLVI 175
Cdd:COG2230 115 ---ADGQFDAIVSIG-MFEHVGP-----ENYPAYFAKVARLLKPGGRLLL 155
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
20-181 4.44e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 66.18  E-value: 4.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   20 DQYADgeaarVWQLYIGDTR--SRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlK 97
Cdd:COG4976  12 DQYAD-----SYDAALVEDLgyEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKA-R 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   98 ERwnrrhePAFDKWVIEEANwmtldkDVPQSaEGGFDAVICLGnSFAHLPDckgdqseHRLALKNIASMVRAGGLLVIDH 177
Cdd:COG4976  86 EK------GVYDRLLVADLA------DLAEP-DGRFDLIVAAD-VLTYLGD-------LAAVFAGVARALKPGGLFIFSV 144


                ....
gi 9506741  178 RNYD 181
Cdd:COG4976 145 EDAD 148
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
60-177 1.57e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 62.53  E-value: 1.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   60 RVLDVACGTGVDSIMLVEE--GFSVTSVDASDKMLKYAlkerwnRRHEPAFDkwvIEEANWMTLDkdvpqsAEGGFDAVI 137
Cdd:COG4106   4 RVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARA------RARLPNVR---FVVADLRDLD------PPEPFDLVV 68

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 9506741  138 ClGNSFAHLPDckgdqseHRLALKNIASMVRAGGLLVIDH 177
Cdd:COG4106  69 S-NAALHWLPD-------HAALLARLAAALAPGGVLAVQV 100
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 60-175 1.94e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 59.75  E-value: 1.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   60 RVLDVACGTGVDSIMLVE-EGFSVTSVDASDKMLKYALKERWNRRHepafDKWVIEEANWMTLDKDVPQSaeggFDAVIC 138
Cdd:cd02440   1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLA----DNVEVLKGDAEELPPEADES----FDVIIS 72

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 9506741  139 lGNSFAHLPDckgdqsEHRLALKNIASMVRAGGLLVI 175
Cdd:cd02440  73 -DPPLHHLVE------DLARFLEEARRLLKPGGVLVL 102
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 62-175 1.64e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 56.90  E-value: 1.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741     62 LDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlkerwNRRHEPAFDKWVIEEANWMTLdkdvpqsAEGGFDAVICLgN 141
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELA-----REKAPREGLTFVVGDAEDLPF-------PDNSFDLVLSS-E 67

                          90       100       110
                  ....*....|....*....|....*....|....
gi 9506741    142 SFAHLPDckgdqseHRLALKNIASMVRAGGLLVI 175
Cdd:pfam08241  68 VLHHVED-------PERALREIARVLKPGGILII 94
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 22-168 6.77e-10

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 57.92  E-value: 6.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741    22 YADGEAARVwQLYIGDTRSRT-AEYKAWLLGLLRQHGCqRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlKERW 100
Cdd:PRK07580  29 YSDAPVSKV-RATVRAGHQRMrDTVLSWLPADGDLTGL-RILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEA-RERA 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9506741   101 NRRHEPafdkwviEEANWMTLDKDvpqSAEGGFDAVICLgNSFAHLPDCKGDQsehrlALKNIASMVR 168
Cdd:PRK07580 106 PEAGLA-------GNITFEVGDLE---SLLGRFDTVVCL-DVLIHYPQEDAAR-----MLAHLASLTR 157
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 34-199 4.72e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 54.36  E-value: 4.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741     34 YIGDTRSRTAEYKAWLLGLLRQHGcqRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMlkyalkerwnrrHEPAFDKWVI 113
Cdd:pfam13489   1 YAHQRERLLADLLLRLLPKLPSPG--RVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIA------------IERALLNVRF 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741    114 EEAnwmtlDKDVPQSAEGGFDAVICLgNSFAHLPDckgdqseHRLALKNIASMVRAGGLLVI-DHRNYDHILS-----TG 187
Cdd:pfam13489  67 DQF-----DEQEAAVPAGKFDVIVAR-EVLEHVPD-------PPALLRQIAALLKPGGLLLLsTPLASDEADRlllewPY 133

                         170
                  ....*....|..
gi 9506741    188 CAPPGKNIYYKS 199
Cdd:pfam13489 134 LRPRNGHISLFS 145
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 44-185 8.39e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 54.54  E-value: 8.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   44 EYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEE-GFSVTSVDASDKMLKYAlkerwNRRHEPAFdkwvIEEANWMTLD 122
Cdd:COG0500  13 GLAALLALLERLPKGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALA-----RARAAKAG----LGNVEFLVAD 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9506741  123 -KDVPQSAEGGFDAVICLGnSFAHLPdckgdQSEHRLALKNIASMVRAGGLLVIDHRNYDHILS 185
Cdd:COG0500  84 lAELDPLPAESFDLVVAFG-VLHHLP-----PEEREALLRELARALKPGGVLLLSASDAAAALS 141
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 62-173 1.86e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 51.21  E-value: 1.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741     62 LDVACGTGVDSIMLVEE--GFSVTSVDASDKMLKYALKErwnrrhepaFDKWVIEEANWMTLDK-DVPQSAEGGFDAVIC 138
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAARER---------LAALGLLNAVRVELFQlDLGELDPGSFDVVVA 71

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 9506741    139 LgNSFAHLPDCKGdqsehrlALKNIASMVRAGGLL 173
Cdd:pfam08242  72 S-NVLHHLADPRA-------VLRNIRRLLKPGGVL 98
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 60-177 7.47e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 50.88  E-value: 7.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741     60 RVLDVACGTGVDSIMLVEEGFS---VTSVDASDKMLKYALKERwnRRHEpaFDKWVIEEANWMTLDKDVpqsAEGGFDAV 136
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEELGPnaeVVGIDISEEAIEKARENA--QKLG--FDNVEFEQGDIEELPELL---EDDKFDVV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 9506741    137 ICLGnSFAHLPDCkgdqsehRLALKNIASMVRAGGLLVIDH 177
Cdd:pfam13847  79 ISNC-VLNHIPDP-------DKVLQEILRVLKPGGRLIISD 111
PRK08317 PRK08317
hypothetical protein; Provisional
 43-181 3.52e-07

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 50.32  E-value: 3.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741    43 AEYKAWLLGLLRQHGCQRVLDVACGTGVDSIML---VEEGFSVTSVDASDKMLKYAlKERwnrrhepafdkwVIEEANWM 119
Cdd:PRK08317   5 RRYRARTFELLAVQPGDRVLDVGCGPGNDARELarrVGPEGRVVGIDRSEAMLALA-KER------------AAGLGPNV 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9506741   120 TLDKDVPQS---AEGGFDAVICLgNSFAHLPDCKGdqsehrlALKNIASMVRAGGLLVIDHRNYD 181
Cdd:PRK08317  72 EFVRGDADGlpfPDGSFDAVRSD-RVLQHLEDPAR-------ALAEIARVLRPGGRVVVLDTDWD 128
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 47-177 1.82e-05

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 44.40  E-value: 1.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   47 AWLLGLLRQHGCQRVLDVACGTGVDSIMLVE---EGFSVTSVDASDKMLKYAlKERWNRRHEPafDKWVIEEANWMTLdk 123
Cdd:COG4122   6 RLLYLLARLLGAKRILEIGTGTGYSTLWLARalpDDGRLTTIEIDPERAAIA-RENFARAGLA--DRIRLILGDALEV-- 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 9506741  124 dVPQSAEGGFDAVIClgnsfahlpDckGDQSEHRLALKNIASMVRAGGLLVIDH 177
Cdd:COG4122  81 -LPRLADGPFDLVFI---------D--ADKSNYPDYLELALPLLRPGGLIVADN 122
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 59-175 5.41e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 43.60  E-value: 5.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741    59 QRVLDVACGTGVDSIMLVEEG---FSVTSVDASDKMLKYAlKERWNRRHEPAFDKWVIEEANWMTLDKDVpqsaeggFDA 135
Cdd:PRK00216  53 DKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLAVG-REKLRDLGLSGNVEFVQGDAEALPFPDNS-------FDA 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 9506741   136 V-ICLG--NsfahLPDckgdqseHRLALKNIASMVRAGGLLVI 175
Cdd:PRK00216 125 VtIAFGlrN----VPD-------IDKALREMYRVLKPGGRLVI 156
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 59-175 7.26e-04

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 39.94  E-value: 7.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741     59 QRVLDVACGTGVDSIML---VEEGFSVTSVDASDKMLKYALKerwnrRHE-PAFDKWVIEEANWMTLDKDVpqsaeggFD 134
Cdd:TIGR01934  41 QKVLDVACGTGDLAIELaksAPDRGKVTGVDFSSEMLEVAKK-----KSElPLNIEFIQADAEALPFEDNS-------FD 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 9506741    135 AVIClgnSFAhLPDCkgdqSEHRLALKNIASMVRAGGLLVI 175
Cdd:TIGR01934 109 AVTI---AFG-LRNV----TDIQKALREMYRVLKPGGRLVI 141
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 49-107 1.05e-03

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 39.74  E-value: 1.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 9506741    49 LLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYAlkerwnRRHEPA 107
Cdd:PRK10258  34 LLAMLPQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQA------RQKDAA 86
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 59-175 5.40e-03

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 37.63  E-value: 5.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   59 QRVLDVACGTGVDSI---MLVEEGFSVTSVDASDKMLKYAlkerwnRRHEPAFDKWVIEEANWmtLDKDVPQS-AEGGFD 134
Cdd:COG5459  82 LTVLDVGAGPGTAAWaaaDAWPSLLDATLLERSAAALALG------RRLARAAANPALETAEW--RLADLAAAlPAPPAD 153

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 9506741  135 AVIClGNSFAHLPDckgdqsEHRLALknIASM-VRAGGLLVI 175
Cdd:COG5459 154 LVVA-SYVLNELAD------AARAAL--VDRLwLAPDGALLI 186
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 39-138 7.15e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 37.44  E-value: 7.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9506741   39 RSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEE--GFSVTSVDASDKMLKYAlkeRWNRRHEPAFDKWVIEEA 116
Cdd:COG2890  94 RPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKErpDARVTAVDISPDALAVA---RRNAERLGLEDRVRFLQG 170

                        90       100
                ....*....|....*....|..
gi 9506741  117 NWMTldkdvPQSAEGGFDAVIC 138
Cdd:COG2890 171 DLFE-----PLPGDGRFDLIVS 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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