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Conserved domains on  [gi|94538350|ref|NP_001035519|]
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protocadherin-17 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 13228088)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-347 1.38e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 1.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  247 SYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDrvrELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDL 326
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 94538350  327 GPNPIPAHCKVTVKLIDRNDN 347
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-579 5.97e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 5.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  477 YVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDvsiytYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKD 556
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|...
gi 94538350  557 SGAPAhLESNATVRVTVLDVNDN 579
Cdd:cd11304   77 GGGPP-LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-239 5.26e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 5.26e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  141 ISENAAPGTRFPLTSAHDPDAGENGLRTY-LLTRDDHGLFGLDVKSrgdGtkfpELVIQKALDREQQNHHTLVLTALDGG 219
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPST---G----EITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 94538350  220 EPPRSATVQINVKVIDSNDN 239
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 361-468 8.56e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 8.56e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  361 LSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGgggglggpggsvPFKLEENYdnfYTVVTDRPLDRETQDEYNV 440
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG------------LFSIDPST---GEITTAKPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*...
gi 94538350  441 TIVARDGGSPPLNSTKSFAIKILDENDN 468
Cdd:cd11304   71 TVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 594-682 6.92e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 6.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  594 ELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTL 673
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82


                 ....*....
gi 94538350  674 SAVAKLIIR 682
Cdd:cd11304   83 SSTATVTIT 91
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 21-112 2.13e-14

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 69.48  E-value: 2.13e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     21 LNYSVPEEQGAGTVIGNIGRDArlqpGLPPAERGGGGRsksgsyRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNA 100
Cdd:pfam08266    2 IRYSVPEETERGSFVGNLAKDL----GLEVGELAARGA------RVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTE 71

                           90
                   ....*....|..
gi 94538350    101 KCQLSLEVFAND 112
Cdd:pfam08266   72 PCVLHFQVLLEN 83
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-347 1.38e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 1.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  247 SYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDrvrELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDL 326
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 94538350  327 GPNPIPAHCKVTVKLIDRNDN 347
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-579 5.97e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 5.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  477 YVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDvsiytYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKD 556
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|...
gi 94538350  557 SGAPAhLESNATVRVTVLDVNDN 579
Cdd:cd11304   77 GGGPP-LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-239 5.26e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 5.26e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  141 ISENAAPGTRFPLTSAHDPDAGENGLRTY-LLTRDDHGLFGLDVKSrgdGtkfpELVIQKALDREQQNHHTLVLTALDGG 219
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPST---G----EITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 94538350  220 EPPRSATVQINVKVIDSNDN 239
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 361-468 8.56e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 8.56e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  361 LSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGgggglggpggsvPFKLEENYdnfYTVVTDRPLDRETQDEYNV 440
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG------------LFSIDPST---GEITTAKPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*...
gi 94538350  441 TIVARDGGSPPLNSTKSFAIKILDENDN 468
Cdd:cd11304   71 TVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 594-682 6.92e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 6.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  594 ELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTL 673
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82


                 ....*....
gi 94538350  674 SAVAKLIIR 682
Cdd:cd11304   83 SSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 266-349 7.95e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 7.95e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     266 NATDADEGPNGEVLYSFssyVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRN 345
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 94538350     346 DNAP 349
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 496-581 2.44e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 2.44e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     496 AQDPDLGQNGTVSYSILPSHIGDvsiytYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAhLESNATVRVTVLD 575
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDG-----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLD 75


                    ....*.
gi 94538350     576 VNDNAP 581
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
248-342 1.11e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 1.11e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350    248 YLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSyvpDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLG 327
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 94538350    328 PNPIPAHCKVTVKLI 342
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 155-241 3.35e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.86  E-value: 3.35e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     155 SAHDPDAGENGLRTYLLTRDDH-GLFGLDvksRGDGtkfpELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKV 233
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdGLFSID---PETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 94538350     234 IDSNDNSP 241
Cdd:smart00112   74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 375-470 6.85e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 6.85e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     375 RVTDRDSGKNGQLQCRVLGGGGTGgggglggpggsvPFKLEENYDnfyTVVTDRPLDRETQDEYNVTIVARDGGSPPLNS 454
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG------------LFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSS 65

                            90
                    ....*....|....*.
gi 94538350     455 TKSFAIKILDENDNPP 470
Cdd:smart00112   66 TATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 611-682 2.18e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 2.18e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 94538350     611 RALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIR 682
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
596-681 1.85e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 1.85e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350    596 QVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSA 675
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*.
gi 94538350    676 VAKLII 681
Cdd:pfam00028   84 TATVTI 89
Cadherin pfam00028
Cadherin domain;
137-234 5.83e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 5.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350    137 IEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDH-GLFGLDVKSRgdgtkfpELVIQKALDREQQNHHTLVLTA 215
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPgGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 94538350    216 LDGGEPPRSATVQINVKVI 234
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
477-574 9.08e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 9.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350    477 YVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVsiytyVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKD 556
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*...
gi 94538350    557 SGAPAhLESNATVRVTVL 574
Cdd:pfam00028   76 SGGPP-LSSTATVTITVL 92
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 21-112 2.13e-14

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 69.48  E-value: 2.13e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     21 LNYSVPEEQGAGTVIGNIGRDArlqpGLPPAERGGGGRsksgsyRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNA 100
Cdd:pfam08266    2 IRYSVPEETERGSFVGNLAKDL----GLEVGELAARGA------RVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTE 71

                           90
                   ....*....|..
gi 94538350    101 KCQLSLEVFAND 112
Cdd:pfam08266   72 PCVLHFQVLLEN 83
Cadherin pfam00028
Cadherin domain;
357-463 4.94e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 4.94e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350    357 RQGALSEAAPPGTVIALVRVTDRDSGKNGQLqcrvlggggtggggglggpggsVPFKLEENYDNFYTVVTD-------RP 429
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI----------------------FYSILGGGPGGNFRIDPDtgdisttKP 58

                           90       100       110
                   ....*....|....*....|....*....|....
gi 94538350    430 LDRETQDEYNVTIVARDGGSPPLNSTKSFAIKIL 463
Cdd:pfam00028   59 LDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 22-128 1.28e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350   22 NYSVPEEQGAGTVIGNI-------GRDARLQpglppaerggggrsksgsYRVLENSAPHLLDVDADSGLLYTKQRIDRES 94
Cdd:cd11304    3 EVSVPENAPPGTVVLTVsatdpdsGENGEVT------------------YSIVSGNEDGLFSIDPSTGEITTAKPLDREE 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 94538350   95 LCRHNakcqlsLEVFANDKEI------CMIKVEIQDINDN 128
Cdd:cd11304   65 QSSYT------LTVTATDGGGpplsstATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-130 1.30e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 1.30e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 94538350      64 YRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNakcqlsLEVFANDKEI------CMIKVEIQDINDNAP 130
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYT------LTVEATDGGGpplsstATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 247-347 1.38e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 1.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  247 SYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDrvrELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDL 326
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED---GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|.
gi 94538350  327 GPNPIPAHCKVTVKLIDRNDN 347
Cdd:cd11304   78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-579 5.97e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 5.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  477 YVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDvsiytYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKD 556
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|...
gi 94538350  557 SGAPAhLESNATVRVTVLDVNDN 579
Cdd:cd11304   77 GGGPP-LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 141-239 5.26e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 5.26e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  141 ISENAAPGTRFPLTSAHDPDAGENGLRTY-LLTRDDHGLFGLDVKSrgdGtkfpELVIQKALDREQQNHHTLVLTALDGG 219
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYsIVSGNEDGLFSIDPST---G----EITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|
gi 94538350  220 EPPRSATVQINVKVIDSNDN 239
Cdd:cd11304   79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 361-468 8.56e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 8.56e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  361 LSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGgggglggpggsvPFKLEENYdnfYTVVTDRPLDRETQDEYNV 440
Cdd:cd11304    6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG------------LFSIDPST---GEITTAKPLDREEQSSYTL 70

                         90       100
                 ....*....|....*....|....*...
gi 94538350  441 TIVARDGGSPPLNSTKSFAIKILDENDN 468
Cdd:cd11304   71 TVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 594-682 6.92e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 6.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  594 ELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTL 673
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82


                 ....*....
gi 94538350  674 SAVAKLIIR 682
Cdd:cd11304   83 SSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 266-349 7.95e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 7.95e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     266 NATDADEGPNGEVLYSFssyVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRN 345
Cdd:smart00112    1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 94538350     346 DNAP 349
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 496-581 2.44e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 2.44e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     496 AQDPDLGQNGTVSYSILPSHIGDvsiytYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAhLESNATVRVTVLD 575
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDG-----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLD 75


                    ....*.
gi 94538350     576 VNDNAP 581
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
248-342 1.11e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 1.11e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350    248 YLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSyvpDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLG 327
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 94538350    328 PNPIPAHCKVTVKLI 342
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 155-241 3.35e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.86  E-value: 3.35e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     155 SAHDPDAGENGLRTYLLTRDDH-GLFGLDvksRGDGtkfpELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKV 233
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdGLFSID---PETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                    ....*...
gi 94538350     234 IDSNDNSP 241
Cdd:smart00112   74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 375-470 6.85e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 6.85e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     375 RVTDRDSGKNGQLQCRVLGGGGTGgggglggpggsvPFKLEENYDnfyTVVTDRPLDRETQDEYNVTIVARDGGSPPLNS 454
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDG------------LFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSS 65

                            90
                    ....*....|....*.
gi 94538350     455 TKSFAIKILDENDNPP 470
Cdd:smart00112   66 TATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 611-682 2.18e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.78  E-value: 2.18e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 94538350     611 RALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIR 682
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
596-681 1.85e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 1.85e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350    596 QVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSA 675
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*.
gi 94538350    676 VAKLII 681
Cdd:pfam00028   84 TATVTI 89
Cadherin pfam00028
Cadherin domain;
137-234 5.83e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 5.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350    137 IEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDH-GLFGLDVKSRgdgtkfpELVIQKALDREQQNHHTLVLTA 215
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPgGNFRIDPDTG-------DISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 94538350    216 LDGGEPPRSATVQINVKVI 234
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
477-574 9.08e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 9.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350    477 YVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVsiytyVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKD 556
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*...
gi 94538350    557 SGAPAhLESNATVRVTVL 574
Cdd:pfam00028   76 SGGPP-LSSTATVTITVL 92
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 21-112 2.13e-14

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 69.48  E-value: 2.13e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     21 LNYSVPEEQGAGTVIGNIGRDArlqpGLPPAERGGGGRsksgsyRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNA 100
Cdd:pfam08266    2 IRYSVPEETERGSFVGNLAKDL----GLEVGELAARGA------RVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTE 71

                           90
                   ....*....|..
gi 94538350    101 KCQLSLEVFAND 112
Cdd:pfam08266   72 PCVLHFQVLLEN 83
Cadherin pfam00028
Cadherin domain;
357-463 4.94e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 4.94e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350    357 RQGALSEAAPPGTVIALVRVTDRDSGKNGQLqcrvlggggtggggglggpggsVPFKLEENYDNFYTVVTD-------RP 429
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI----------------------FYSILGGGPGGNFRIDPDtgdisttKP 58

                           90       100       110
                   ....*....|....*....|....*....|....
gi 94538350    430 LDRETQDEYNVTIVARDGGSPPLNSTKSFAIKIL 463
Cdd:pfam00028   59 LDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 22-128 1.28e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350   22 NYSVPEEQGAGTVIGNI-------GRDARLQpglppaerggggrsksgsYRVLENSAPHLLDVDADSGLLYTKQRIDRES 94
Cdd:cd11304    3 EVSVPENAPPGTVVLTVsatdpdsGENGEVT------------------YSIVSGNEDGLFSIDPSTGEITTAKPLDREE 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 94538350   95 LCRHNakcqlsLEVFANDKEI------CMIKVEIQDINDN 128
Cdd:cd11304   65 QSSYT------LTVTATDGGGpplsstATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-130 1.30e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.82  E-value: 1.30e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 94538350      64 YRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNakcqlsLEVFANDKEI------CMIKVEIQDINDNAP 130
Cdd:smart00112   15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYT------LTVEATDGGGpplsstATVTITVLDVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 253-347 2.41e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 41.56  E-value: 2.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350  253 PENAPLGTVVIDLnATDADEgpNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIP 332
Cdd:cd00031    7 VEGRSRGSFRVSI-PTDLIA--SSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQ 83

                         90
                 ....*....|....*
gi 94538350  333 AHCKVTVKLIDRNDN 347
Cdd:cd00031   84 TSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
22-123 7.14e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 36.89  E-value: 7.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 94538350     22 NYSVPEEQGAGTVIGNIG-RDarlqPGLPPAERGGggrsksgsYRVLENSAPHLLDVDADSGLLYTKQRIDRESlcrhNA 100
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTaTD----PDLGPNGRIF--------YSILGGGPGGNFRIDPDTGDISTTKPLDRES----IG 65

                           90       100
                   ....*....|....*....|....*..
gi 94538350    101 KCQLSLEVFANDK----EICMIKVEIQ 123
Cdd:pfam00028   66 EYELTVEATDSGGpplsSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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