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Conserved domains on  [gi|944325217|ref|YP_009174024|]
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22K [Simian adenovirus 13]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adeno_L433K_22K super family cl12642
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
 39-166 9.60e-16

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


The actual alignment was detected with superfamily member pfam11081:

Pssm-ID: 314108  Cd Length: 168  Bit Score: 70.81  E-value: 9.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944325217   39 WESQG------EEDMEEEWDSL--ASDEGEAEAETEEASVAKPS-----LAKRVSNVTTTSDQ-------RTVSRRWDST 98
Cdd:pfam11081  21 WDSQAeevldeEEEMMEDWDSLdeASEAEEVSDETPSPSVAFPSpapqkLATVPSIATTSAPQappalpvRRPNRRWDTT 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 944325217   99 N--AAPAGKTLSLA---KPRQGYRSWRAHKNAIINCLEncggnisftrRFMLFRNGIAIPRNVLHYYRHSYSP 166
Cdd:pfam11081 101 GtrAGKSKQPPPLAqeqQQRQGYRSWRGIKNRTPASLT----------RRYLYHRDLKKLRQYLEDAKKLYSK 163
 
Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
 39-166 9.60e-16

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


Pssm-ID: 314108  Cd Length: 168  Bit Score: 70.81  E-value: 9.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944325217   39 WESQG------EEDMEEEWDSL--ASDEGEAEAETEEASVAKPS-----LAKRVSNVTTTSDQ-------RTVSRRWDST 98
Cdd:pfam11081  21 WDSQAeevldeEEEMMEDWDSLdeASEAEEVSDETPSPSVAFPSpapqkLATVPSIATTSAPQappalpvRRPNRRWDTT 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 944325217   99 N--AAPAGKTLSLA---KPRQGYRSWRAHKNAIINCLEncggnisftrRFMLFRNGIAIPRNVLHYYRHSYSP 166
Cdd:pfam11081 101 GtrAGKSKQPPPLAqeqQQRQGYRSWRGIKNRTPASLT----------RRYLYHRDLKKLRQYLEDAKKLYSK 163
 
Name Accession Description Interval E-value
Adeno_L433K_22K pfam11081
Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late ...
 39-166 9.60e-16

Adenovirus L4-33K/L4-22K; Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that up-regulates several MLTU splice acceptor sites as the late phase progresses. L4-22K plays a role in genome packaging via its binding, in association with IVa2, to the A2 sequence within the packaging signal. Additionally, L4-22K plays an important role in the temporal switch from the early to late phase of infection by regulating both early and late gene expression.


Pssm-ID: 314108  Cd Length: 168  Bit Score: 70.81  E-value: 9.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944325217   39 WESQG------EEDMEEEWDSL--ASDEGEAEAETEEASVAKPS-----LAKRVSNVTTTSDQ-------RTVSRRWDST 98
Cdd:pfam11081  21 WDSQAeevldeEEEMMEDWDSLdeASEAEEVSDETPSPSVAFPSpapqkLATVPSIATTSAPQappalpvRRPNRRWDTT 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 944325217   99 N--AAPAGKTLSLA---KPRQGYRSWRAHKNAIINCLEncggnisftrRFMLFRNGIAIPRNVLHYYRHSYSP 166
Cdd:pfam11081 101 GtrAGKSKQPPPLAqeqQQRQGYRSWRGIKNRTPASLT----------RRYLYHRDLKKLRQYLEDAKKLYSK 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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