NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|944067603|gb|KQK03087|]
View 

hypothetical protein BRADI_2g05487v3 [Brachypodium distachyon]

Protein Classification

F-box protein( domain architecture ID 1903488)

F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-446 1.76e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 1.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 137 LVETYRSHSARITCMRLFPlidtplfrsdthtKEKALVTSSTDRTVRLcWK----GCSRSYKGHSGPVTALAdkLLCDGE 212
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP-------------DGKLLATGSGDGTIKV-WDletgELLRTLKGHTGPVRDVA--ASADGT 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 213 FkvLATGGEDCAIRLWSMSTKAkshsLISTLHGHEKTLSllSVAWHKSSLLVSSSKDSK-VKVWDTmappssVSSSCVgg 291
Cdd:cd00200   65 Y--LASGSSDKTIRLWDLETGE----CVRTLTGHTSYVS--SVAFSPDGRILSSSSRDKtIKVWDV------ETGKCL-- 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 292 thlnssgppIAMKCHQSLC----------YIAAGSE---VTAIDLRTMKKASVLALCNQRIISCEMLPSEWLICTGVKDK 358
Cdd:cd00200  129 ---------TTLRGHTDWVnsvafspdgtFVASSSQdgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 359 AL-LWDIRKSQELAntVAELHSDGPVTLLHLDPYKVVTGAPLDGQVHVWETQTGRLVNTLSCGEpgkspggTTVSAMAV- 436
Cdd:cd00200  200 TIkLWDLSTGKCLG--TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT-------NSVTSLAWs 270

                        330
                 ....*....|.
gi 944067603 437 -DGCRIATTES 446
Cdd:cd00200  271 pDGKRLASGSA 281
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 12-49 2.29e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22140:

Pssm-ID: 459239  Cd Length: 38  Bit Score: 35.81  E-value: 2.29e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 944067603  12 LVDLDGDVLAHCARHLGARDVASLAMACRPLHAAAYCD 49
Cdd:cd22140    1 LLDLPEDLLLHILSFLNLRDRLNLSLTCKRLRALAYSD 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-446 1.76e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 1.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 137 LVETYRSHSARITCMRLFPlidtplfrsdthtKEKALVTSSTDRTVRLcWK----GCSRSYKGHSGPVTALAdkLLCDGE 212
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP-------------DGKLLATGSGDGTIKV-WDletgELLRTLKGHTGPVRDVA--ASADGT 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 213 FkvLATGGEDCAIRLWSMSTKAkshsLISTLHGHEKTLSllSVAWHKSSLLVSSSKDSK-VKVWDTmappssVSSSCVgg 291
Cdd:cd00200   65 Y--LASGSSDKTIRLWDLETGE----CVRTLTGHTSYVS--SVAFSPDGRILSSSSRDKtIKVWDV------ETGKCL-- 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 292 thlnssgppIAMKCHQSLC----------YIAAGSE---VTAIDLRTMKKASVLALCNQRIISCEMLPSEWLICTGVKDK 358
Cdd:cd00200  129 ---------TTLRGHTDWVnsvafspdgtFVASSSQdgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 359 AL-LWDIRKSQELAntVAELHSDGPVTLLHLDPYKVVTGAPLDGQVHVWETQTGRLVNTLSCGEpgkspggTTVSAMAV- 436
Cdd:cd00200  200 TIkLWDLSTGKCLG--TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT-------NSVTSLAWs 270

                        330
                 ....*....|.
gi 944067603 437 -DGCRIATTES 446
Cdd:cd00200  271 pDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
134-443 1.25e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 1.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 134 DNELVETYRSHSARITCMRlfplidtplFRSDTHTkekaLVTSSTDRTVRLcWK----GCSRSYKGHSGPVTALAdkLLC 209
Cdd:COG2319  151 TGKLLRTLTGHSGAVTSVA---------FSPDGKL----LASGSDDGTVRL-WDlatgKLLRTLTGHTGAVRSVA--FSP 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 210 DGefKVLATGGEDCAIRLWSMSTKAkshsLISTLHGHekTLSLLSVAWHKssllvssskdskvkvwdtmappssvssscv 289
Cdd:COG2319  215 DG--KLLASGSADGTVRLWDLATGK----LLRTLTGH--SGSVRSVAFSP------------------------------ 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 290 GGTHLnssgppiamkchqslcyiAAGSEVTAI---DLRTMKKASVLALCNQRIISCEMLPSEWLICTGVKDKAL-LWDIR 365
Cdd:COG2319  257 DGRLL------------------ASGSADGTVrlwDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVrLWDLA 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 366 KSQELANTVAelHSDGPVTL-LHLDPYKVVTGAPlDGQVHVWETQTGRLVNTLScGEPGkspggtTVSAMAV--DGCRIA 442
Cdd:COG2319  319 TGKLLRTLTG--HTGAVRSVaFSPDGKTLASGSD-DGTVRLWDLATGELLRTLT-GHTG------AVTSVAFspDGRTLA 388


                 .
gi 944067603 443 T 443
Cdd:COG2319  389 S 389
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 189-229 2.26e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.26e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 944067603   189 CSRSYKGHSGPVTALAdkllCDGEFKVLATGGEDCAIRLWS 229
Cdd:smart00320   4 LLKTLKGHTGPVTSVA----FSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
189-229 8.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 944067603  189 CSRSYKGHSGPVTALAdkLLCDGEFkvLATGGEDCAIRLWS 229
Cdd:pfam00400   3 LLKTLEGHTGSVTSLA--FSPDGKL--LASGSDDGTVKVWD 39
F-box_D3-like cd22140
F-box domain found in Oryza sativa F-box/LRR-repeat Max2 homolog (D3) and similar proteins; D3 ...
 12-49 2.29e-03

F-box domain found in Oryza sativa F-box/LRR-repeat Max2 homolog (D3) and similar proteins; D3 is the ortholog of Arabidopsis MORE AXILLARY GROWTH2 (MAX2) and DWARF14 (AtD14) in rice. These proteins are essential signaling components to regulate strigolactone (SL)-repressed plant branching. In rice shoot branching inhibition, the SL-metabolizing alpha/beta hydrolase D14 interacts with the F-box protein D3 to ubiquitinate and degrade the transcription repressor D53. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438912  Cd Length: 38  Bit Score: 35.81  E-value: 2.29e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 944067603  12 LVDLDGDVLAHCARHLGARDVASLAMACRPLHAAAYCD 49
Cdd:cd22140    1 LLDLPEDLLLHILSFLNLRDRLNLSLTCKRLRALAYSD 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-446 1.76e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 1.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 137 LVETYRSHSARITCMRLFPlidtplfrsdthtKEKALVTSSTDRTVRLcWK----GCSRSYKGHSGPVTALAdkLLCDGE 212
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP-------------DGKLLATGSGDGTIKV-WDletgELLRTLKGHTGPVRDVA--ASADGT 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 213 FkvLATGGEDCAIRLWSMSTKAkshsLISTLHGHEKTLSllSVAWHKSSLLVSSSKDSK-VKVWDTmappssVSSSCVgg 291
Cdd:cd00200   65 Y--LASGSSDKTIRLWDLETGE----CVRTLTGHTSYVS--SVAFSPDGRILSSSSRDKtIKVWDV------ETGKCL-- 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 292 thlnssgppIAMKCHQSLC----------YIAAGSE---VTAIDLRTMKKASVLALCNQRIISCEMLPSEWLICTGVKDK 358
Cdd:cd00200  129 ---------TTLRGHTDWVnsvafspdgtFVASSSQdgtIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 359 AL-LWDIRKSQELAntVAELHSDGPVTLLHLDPYKVVTGAPLDGQVHVWETQTGRLVNTLSCGEpgkspggTTVSAMAV- 436
Cdd:cd00200  200 TIkLWDLSTGKCLG--TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT-------NSVTSLAWs 270

                        330
                 ....*....|.
gi 944067603 437 -DGCRIATTES 446
Cdd:cd00200  271 pDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
134-443 1.25e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.64  E-value: 1.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 134 DNELVETYRSHSARITCMRlfplidtplFRSDTHTkekaLVTSSTDRTVRLcWK----GCSRSYKGHSGPVTALAdkLLC 209
Cdd:COG2319  151 TGKLLRTLTGHSGAVTSVA---------FSPDGKL----LASGSDDGTVRL-WDlatgKLLRTLTGHTGAVRSVA--FSP 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 210 DGefKVLATGGEDCAIRLWSMSTKAkshsLISTLHGHekTLSLLSVAWHKssllvssskdskvkvwdtmappssvssscv 289
Cdd:COG2319  215 DG--KLLASGSADGTVRLWDLATGK----LLRTLTGH--SGSVRSVAFSP------------------------------ 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 290 GGTHLnssgppiamkchqslcyiAAGSEVTAI---DLRTMKKASVLALCNQRIISCEMLPSEWLICTGVKDKAL-LWDIR 365
Cdd:COG2319  257 DGRLL------------------ASGSADGTVrlwDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVrLWDLA 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 366 KSQELANTVAelHSDGPVTL-LHLDPYKVVTGAPlDGQVHVWETQTGRLVNTLScGEPGkspggtTVSAMAV--DGCRIA 442
Cdd:COG2319  319 TGKLLRTLTG--HTGAVRSVaFSPDGKTLASGSD-DGTVRLWDLATGELLRTLT-GHTG------AVTSVAFspDGRTLA 388


                 .
gi 944067603 443 T 443
Cdd:COG2319  389 S 389
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 134-407 2.25e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 2.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 134 DNELVETYRSHSARITCMRLfplidtplfrsdtHTKEKALVTSSTDRTVRLcWK----GCSRSYKGHSGPVTALAdkLLC 209
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAF-------------SPDGRILSSSSRDKTIKV-WDvetgKCLTTLRGHTDWVNSVA--FSP 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 210 DGEFkvLATGGEDCAIRLWSMSTkaksHSLISTLHGHEKtlSLLSVAWHkssllvssskdskvkvwdtmappssvssscv 289
Cdd:cd00200  146 DGTF--VASSSQDGTIKLWDLRT----GKCVATLTGHTG--EVNSVAFS------------------------------- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 290 ggthlnssgppiamkcHQSLCYIAAGSEVTAI--DLRTMKKASVLALCNQRIISCEMLPSEWLICTGVKDKAL-LWDIRK 366
Cdd:cd00200  187 ----------------PDGEKLLSSSSDGTIKlwDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIrVWDLRT 250

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 944067603 367 SQELAntVAELHsDGPVTLLHLDPYK--VVTGApLDGQVHVWE 407
Cdd:cd00200  251 GECVQ--TLSGH-TNSVTSLAWSPDGkrLASGS-ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
171-443 4.85e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 4.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 171 KALVTSSTDRTVRLcW----KGCSRSYKGHSGPVTALAdkLLCDGefKVLATGGEDCAIRLWSMSTKAkshsLISTLHGH 246
Cdd:COG2319  133 KTLASGSADGTVRL-WdlatGKLLRTLTGHSGAVTSVA--FSPDG--KLLASGSDDGTVRLWDLATGK----LLRTLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 247 ekTLSLLSVAWHKssllvssskdskvkvwdtmappssvssscvGGThlnssgppiamkchqslcYIAAGSE---VTAIDL 323
Cdd:COG2319  204 --TGAVRSVAFSP------------------------------DGK------------------LLASGSAdgtVRLWDL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 324 RTMKKASVLALCNQRIISCEMLP-SEWLICTGVKDKALLWDIRKSQELanTVAELHSDGPVTL-LHLDPYKVVTGApLDG 401
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPdGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNSVaFSPDGKLLASGS-DDG 310

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 944067603 402 QVHVWETQTGRLVNTLScgepGKSPGGTTVsAMAVDGCRIAT 443
Cdd:COG2319  311 TVRLWDLATGKLLRTLT----GHTGAVRSV-AFSPDGKTLAS 347
WD40 COG2319
WD40 repeat [General function prediction only];
171-443 1.69e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.62  E-value: 1.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 171 KALVTSSTDRTVRLcW----KGCSRSYKGHSGPVTALAdkLLCDGefKVLATGGEDCAIRLWSMSTKAkshsLISTLHGH 246
Cdd:COG2319   91 RLLASASADGTVRL-WdlatGLLLRTLTGHTGAVRSVA--FSPDG--KTLASGSADGTVRLWDLATGK----LLRTLTGH 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 247 EKTLSllSVAWHKssllvssskdskvkvwdtmappssvssscvGGThlnssgppiamkchqslcYIAAGSEVTAI---DL 323
Cdd:COG2319  162 SGAVT--SVAFSP------------------------------DGK------------------LLASGSDDGTVrlwDL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 324 RTMKKASVLALCNQRIISCEMLPSEWLICTGVKDKAL-LWDIRKSQELANTVaelHSDGPVTLLHLDPY-KVVTGAPLDG 401
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVrLWDLATGKLLRTLT---GHSGSVRSVAFSPDgRLLASGSADG 268

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 944067603 402 QVHVWETQTGRLVNTLScGEPGkspggtTVSAMAV--DGCRIAT 443
Cdd:COG2319  269 TVRLWDLATGELLRTLT-GHSG------GVNSVAFspDGKLLAS 305
WD40 COG2319
WD40 repeat [General function prediction only];
118-258 1.23e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 944067603 118 SQGPVAKILNVTLGsldnELVETYRSHSARITCMRlfplidtplFRSDthtkEKALVTSSTDRTVRLcW----KGCSRSY 193
Cdd:COG2319  265 SADGTVRLWDLATG----ELLRTLTGHSGGVNSVA---------FSPD----GKLLASGSDDGTVRL-WdlatGKLLRTL 326

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 944067603 194 KGHSGPVTALAdkLLCDGefKVLATGGEDCAIRLWSMSTKAkshsLISTLHGHEKTLSllSVAWH 258
Cdd:COG2319  327 TGHTGAVRSVA--FSPDG--KTLASGSDDGTVRLWDLATGE----LLRTLTGHTGAVT--SVAFS 381
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 189-229 2.26e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.26e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 944067603   189 CSRSYKGHSGPVTALAdkllCDGEFKVLATGGEDCAIRLWS 229
Cdd:smart00320   4 LLKTLKGHTGPVTSVA----FSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
189-229 8.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 944067603  189 CSRSYKGHSGPVTALAdkLLCDGEFkvLATGGEDCAIRLWS 229
Cdd:pfam00400   3 LLKTLEGHTGSVTSLA--FSPDGKL--LASGSDDGTVKVWD 39
F-box_D3-like cd22140
F-box domain found in Oryza sativa F-box/LRR-repeat Max2 homolog (D3) and similar proteins; D3 ...
 12-49 2.29e-03

F-box domain found in Oryza sativa F-box/LRR-repeat Max2 homolog (D3) and similar proteins; D3 is the ortholog of Arabidopsis MORE AXILLARY GROWTH2 (MAX2) and DWARF14 (AtD14) in rice. These proteins are essential signaling components to regulate strigolactone (SL)-repressed plant branching. In rice shoot branching inhibition, the SL-metabolizing alpha/beta hydrolase D14 interacts with the F-box protein D3 to ubiquitinate and degrade the transcription repressor D53. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438912  Cd Length: 38  Bit Score: 35.81  E-value: 2.29e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 944067603  12 LVDLDGDVLAHCARHLGARDVASLAMACRPLHAAAYCD 49
Cdd:cd22140    1 LLDLPEDLLLHILSFLNLRDRLNLSLTCKRLRALAYSD 38
F-box_AtSKIP3-like cd22162
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar ...
 12-56 2.37e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 3 (AtSKIP3) and similar proteins; AtSKIP3, also called F-box protein SKIP3, F-box protein PP2-B9, or protein PHLOEM PROTEIN 2-LIKE B9, is a component of SCF (SKP1-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1. This subfamily also includes many other Arabidopsis thaliana protein PHLOEM PROTEIN 2-LIKE proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438933  Cd Length: 46  Bit Score: 36.02  E-value: 2.37e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 944067603  12 LVDLDGDVLAHCARHLGARDVASLAMACRPLHAAAYCDAVWYRLY 56
Cdd:cd22162    1 LEDLPEDCIALILSFTSPRDVCRLSAVSKTFRSAAESDVVWERFL 45
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
 11-57 2.45e-03

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 36.04  E-value: 2.45e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 944067603  11 TLVDLDGDVLAHCARHLGARDVASLAMACRPLHAAAYCDAVWYRLYR 57
Cdd:cd20090    1 PLLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLISRDAVWRRIAR 47
F-box_FBXO24 cd22098
F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called ...
 11-57 2.99e-03

F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438870  Cd Length: 47  Bit Score: 35.76  E-value: 2.99e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 944067603  11 TLVDLDGDVLAHCARHLGARDVASLAMACRPLHAAAYCDAVWYRLYR 57
Cdd:cd22098    1 SLLDLPPEILDRIISFLPVKDIVSLGQTCRYFHEVCNSEAVWRRLCR 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH