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Conserved domains on  [gi|941094773|ref|WP_055063881|]
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G5 domain-containing protein [Bifidobacterium pseudocatenulatum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YabE COG3583
Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function ...
 83-326 9.16e-31

Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function unknown];


:

Pssm-ID: 442802 [Multi-domain]  Cd Length: 335  Bit Score: 118.82  E-value: 9.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941094773  83 VTVKINGKSRVVPgTNFTDVKSVLDAGDITLEPEDTVSPSLTTKVDEKTVITVQRAGASVEVSDTAIGFNVVKKETSSLP 162
Cdd:COG3583   95 VTVVVDGKTRTVT-TTATTVGEALAEAGITLGEDDRVSPALDAPLTDGMTITVTRVTTKTVTEEEPIPFETVRKEDPSLP 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941094773 163 EGQEKVEREGEEGVMETTNLVTKSGDTVVSSNMISSYVKKAPVDKVILVGTGSTSSSSSSASASIGTtvpaGEMQQWAHD 242
Cdd:COG3583  174 KGETKVVQEGVPGVKEVTYRVTYENGKEVSREVVSEKVTKEPVDEVVAVGTKPRPAPAPVPAGSGSG----GGGSSTGSG 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941094773 243 YLLSNGYTEADFTATVYIITHESGWSVTATNPSSGAYGLPQALPGSKMVSAGADWATNYQTQLKWFWGYCAQRYGSIQGA 322
Cdd:COG3583  250 GYGGLAASSATTAASGGGTGAPGGGGAARPTAGAVAGVVVVGGGGGGGPGGGGGGGAAAGGGGGGGGGGAIDGAEGGSSA 329


                 ....
gi 941094773 323 YTYW 326
Cdd:COG3583  330 AAGG 333
 
Name Accession Description Interval E-value
YabE COG3583
Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function ...
 83-326 9.16e-31

Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function unknown];


Pssm-ID: 442802 [Multi-domain]  Cd Length: 335  Bit Score: 118.82  E-value: 9.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941094773  83 VTVKINGKSRVVPgTNFTDVKSVLDAGDITLEPEDTVSPSLTTKVDEKTVITVQRAGASVEVSDTAIGFNVVKKETSSLP 162
Cdd:COG3583   95 VTVVVDGKTRTVT-TTATTVGEALAEAGITLGEDDRVSPALDAPLTDGMTITVTRVTTKTVTEEEPIPFETVRKEDPSLP 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941094773 163 EGQEKVEREGEEGVMETTNLVTKSGDTVVSSNMISSYVKKAPVDKVILVGTGSTSSSSSSASASIGTtvpaGEMQQWAHD 242
Cdd:COG3583  174 KGETKVVQEGVPGVKEVTYRVTYENGKEVSREVVSEKVTKEPVDEVVAVGTKPRPAPAPVPAGSGSG----GGGSSTGSG 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941094773 243 YLLSNGYTEADFTATVYIITHESGWSVTATNPSSGAYGLPQALPGSKMVSAGADWATNYQTQLKWFWGYCAQRYGSIQGA 322
Cdd:COG3583  250 GYGGLAASSATTAASGGGTGAPGGGGAARPTAGAVAGVVVVGGGGGGGPGGGGGGGAAAGGGGGGGGGGAIDGAEGGSSA 329


                 ....
gi 941094773 323 YTYW 326
Cdd:COG3583  330 AAGG 333
G5 pfam07501
G5 domain; This domain is found in a wide range of extracellular proteins. It is found ...
 141-211 2.17e-14

G5 domain; This domain is found in a wide range of extracellular proteins. It is found tandemly repeated in up to 8 copies. It is found in the N-terminus of peptidases belonging to the M26 family which cleave human IgA. The domain is also found in proteins involved in metabolism of bacterial cell walls suggesting this domain may have an adhesive function.


Pssm-ID: 462185 [Multi-domain]  Cd Length: 75  Bit Score: 67.19  E-value: 2.17e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 941094773  141 SVEVSDTAIGFNVVKKETSSLPEGQEKVEREGEEGVMETTNLVTKSGDTVVSSNMISSYVKKAPVDKVILV 211
Cdd:pfam07501   2 KTVTEEEEIPFETVTKEDPSLPKGEEKVVQEGKPGEKEVTYKVTYVNGKEVSREVVSEEVTKEPVDEVVAV 72
RPF cd13925
core lysozyme-like domain of resuscitation-promoting factor proteins; Resuscitation-promoting ...
 259-288 1.23e-04

core lysozyme-like domain of resuscitation-promoting factor proteins; Resuscitation-promoting factor (RPF) proteins, found in various (G+C)-rich Gram-positive bacteria, act to reactivate cultures from stationary phase. This protein shares elements of the structural core of lysozyme and related proteins. Furthermore, it shares a conserved active site glutamate which is required for activity, and has a polysaccharide binding cleft that corresponds to the peptidoglycan binding cleft of lysozyme. Muralytic activity of Rpf in Micrococcus luteus correlates with resuscitation, supporting a mechanism dependent on cleavage of peptidoglycan by RPF.


Pssm-ID: 381607 [Multi-domain]  Cd Length: 71  Bit Score: 39.67  E-value: 1.23e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 941094773 259 YIITHESGWSVTATNPSSGAYGLPQALPGS 288
Cdd:cd13925    5 AIAQCESGGNWNAVNTGNGYYGGLQFLQGT 34
 
Name Accession Description Interval E-value
YabE COG3583
Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function ...
 83-326 9.16e-31

Uncharacterized conserved protein YabE, contains G5 and tandem DUF348 domains [Function unknown];


Pssm-ID: 442802 [Multi-domain]  Cd Length: 335  Bit Score: 118.82  E-value: 9.16e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941094773  83 VTVKINGKSRVVPgTNFTDVKSVLDAGDITLEPEDTVSPSLTTKVDEKTVITVQRAGASVEVSDTAIGFNVVKKETSSLP 162
Cdd:COG3583   95 VTVVVDGKTRTVT-TTATTVGEALAEAGITLGEDDRVSPALDAPLTDGMTITVTRVTTKTVTEEEPIPFETVRKEDPSLP 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941094773 163 EGQEKVEREGEEGVMETTNLVTKSGDTVVSSNMISSYVKKAPVDKVILVGTGSTSSSSSSASASIGTtvpaGEMQQWAHD 242
Cdd:COG3583  174 KGETKVVQEGVPGVKEVTYRVTYENGKEVSREVVSEKVTKEPVDEVVAVGTKPRPAPAPVPAGSGSG----GGGSSTGSG 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 941094773 243 YLLSNGYTEADFTATVYIITHESGWSVTATNPSSGAYGLPQALPGSKMVSAGADWATNYQTQLKWFWGYCAQRYGSIQGA 322
Cdd:COG3583  250 GYGGLAASSATTAASGGGTGAPGGGGAARPTAGAVAGVVVVGGGGGGGPGGGGGGGAAAGGGGGGGGGGAIDGAEGGSSA 329


                 ....
gi 941094773 323 YTYW 326
Cdd:COG3583  330 AAGG 333
G5 pfam07501
G5 domain; This domain is found in a wide range of extracellular proteins. It is found ...
 141-211 2.17e-14

G5 domain; This domain is found in a wide range of extracellular proteins. It is found tandemly repeated in up to 8 copies. It is found in the N-terminus of peptidases belonging to the M26 family which cleave human IgA. The domain is also found in proteins involved in metabolism of bacterial cell walls suggesting this domain may have an adhesive function.


Pssm-ID: 462185 [Multi-domain]  Cd Length: 75  Bit Score: 67.19  E-value: 2.17e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 941094773  141 SVEVSDTAIGFNVVKKETSSLPEGQEKVEREGEEGVMETTNLVTKSGDTVVSSNMISSYVKKAPVDKVILV 211
Cdd:pfam07501   2 KTVTEEEEIPFETVTKEDPSLPKGEEKVVQEGKPGEKEVTYKVTYVNGKEVSREVVSEEVTKEPVDEVVAV 72
DUF348 pfam03990
G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is ...
 83-124 1.63e-06

G5-linked-Ubiquitin-like domain; This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593. This protein is involved in sporulation part of the SET3C complex, which is required to repress early/middle sporulation genes during meiosis. The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction with the pfam07501 domain, which is involved in various cell surface processes. This domain is also present in the resuscitation-promoting factors RpfB from Mycobacterium tuberculosis and Rpf2 from Corynebacterium glutamicum. These are factors that stimulate resuscitation of dormant cells. This domain has a beta grasp fold. Structural description of this domain revealed a structural conservation between these domains and ubiquitin, hence it is termed UBL-G5.


Pssm-ID: 461121 [Multi-domain]  Cd Length: 41  Bit Score: 44.33  E-value: 1.63e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 941094773   83 VTVKINGKSRVVpGTNFTDVKSVLDAGDITLEPEDTVSPSLT 124
Cdd:pfam03990   1 VTLTVDGKERTV-TTTAGTVGDLLEEAGITLGEHDKVSPSLD 41
RPF cd13925
core lysozyme-like domain of resuscitation-promoting factor proteins; Resuscitation-promoting ...
 259-288 1.23e-04

core lysozyme-like domain of resuscitation-promoting factor proteins; Resuscitation-promoting factor (RPF) proteins, found in various (G+C)-rich Gram-positive bacteria, act to reactivate cultures from stationary phase. This protein shares elements of the structural core of lysozyme and related proteins. Furthermore, it shares a conserved active site glutamate which is required for activity, and has a polysaccharide binding cleft that corresponds to the peptidoglycan binding cleft of lysozyme. Muralytic activity of Rpf in Micrococcus luteus correlates with resuscitation, supporting a mechanism dependent on cleavage of peptidoglycan by RPF.


Pssm-ID: 381607 [Multi-domain]  Cd Length: 71  Bit Score: 39.67  E-value: 1.23e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 941094773 259 YIITHESGWSVTATNPSSGAYGLPQALPGS 288
Cdd:cd13925    5 AIAQCESGGNWNAVNTGNGYYGGLQFLQGT 34
Phage_lysozyme2 pfam18013
Phage tail lysozyme; This domain has a lysozyme like fold. It is found in the tail protein of ...
 240-309 6.04e-04

Phage tail lysozyme; This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.


Pssm-ID: 465617  Cd Length: 139  Bit Score: 39.59  E-value: 6.04e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 941094773  240 AHDYLLSNGYTEADFTATVYIITHESGWSVTATNP---SSGAYGLPQALPGSK------MVSAGADWaTNYQTQLKWFW 309
Cdd:pfam18013   6 IYNFLKSKGYSKAAAAGILGNMQRESGFNPGAVEDeggGGGGYGLVQWTGGRKtalinfAKAKGKSW-SDLDAQLDFLD 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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