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Conserved domains on  [gi|939572606|gb|KPV62513|]
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Ornithine carbamoyltransferase [Candidatus Bathyarchaeota archaeon BA1]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11414683)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 5-338 1.07e-116

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 339.72  E-value: 1.07e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   5 SLYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTT 84
Cdd:COG0078    2 NLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  85 RLEVGEAIKDVAKMYERYGHGLGVRILDQAIdfvygkgnwvVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNI 164
Cdd:COG0078   82 QLGRGESIKDTARVLSRYVDGIMIRTFGHET----------LEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 165 QAKKYVIMW-----GYSrkfrgrcsiqeEMLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKSALH 239
Cdd:COG0078  152 KGLKVAYVGdgnnvANS-----------LLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVK 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 240 GAHVVFPRNWASaallkvgasqFGKENES-RLHEKHRDWMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVMDSSRSVIY 318
Cdd:COG0078  221 GADVVYTDVWVS----------MGQEEEAeERIKAFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVF 290

                        330       340
                 ....*....|....*....|
gi 939572606 319 DQAENGLYTKMAVLALTMGE 338
Cdd:COG0078  291 DEAENRLHAQKALLAWLLGG 310
 
Name Accession Description Interval E-value
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 5-338 1.07e-116

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 339.72  E-value: 1.07e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   5 SLYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTT 84
Cdd:COG0078    2 NLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  85 RLEVGEAIKDVAKMYERYGHGLGVRILDQAIdfvygkgnwvVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNI 164
Cdd:COG0078   82 QLGRGESIKDTARVLSRYVDGIMIRTFGHET----------LEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 165 QAKKYVIMW-----GYSrkfrgrcsiqeEMLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKSALH 239
Cdd:COG0078  152 KGLKVAYVGdgnnvANS-----------LLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVK 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 240 GAHVVFPRNWASaallkvgasqFGKENES-RLHEKHRDWMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVMDSSRSVIY 318
Cdd:COG0078  221 GADVVYTDVWVS----------MGQEEEAeERIKAFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVF 290

                        330       340
                 ....*....|....*....|
gi 939572606 319 DQAENGLYTKMAVLALTMGE 338
Cdd:COG0078  291 DEAENRLHAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 9-337 4.02e-79

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 243.80  E-value: 4.02e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606    9 KDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTTRLEV 88
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   89 GEAIKDVAKMYERYGHGLGVRILDQAIdfvygkgnwvVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNIQAKK 168
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHED----------VEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVK 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  169 YVIMWGysrkfrGRCSIQEEMLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKSALHGAHVVFPRN 248
Cdd:TIGR00658 151 VVYVGD------GNNVCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDV 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  249 WASAALLkvgasqfgKENESRLhEKHRDWMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVMDSSRSVIYDQAENGLYTK 328
Cdd:TIGR00658 225 WVSMGEE--------DKKEERL-KLFRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQ 295


                  ....*....
gi 939572606  329 MAVLALTMG 337
Cdd:TIGR00658 296 KAVMVALLG 304
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 5-336 7.17e-77

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 238.07  E-value: 7.17e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   5 SLYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTT 84
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  85 RLEVGEAIKDVAKMYERYGHGLGVRILDQAIdfvygkgnwvVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNI 164
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHET----------LEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 165 QAKKYVIM---------WgysrkfrgrcsiqeeMLIMTRFGMDVVLAYPPGFELDQKLVDAareNAANSGGHLEVTHDYK 235
Cdd:PRK00779 151 KGLKVAWVgdgnnvansL---------------LLAAALLGFDLRVATPKGYEPDPEIVEK---IAKETGASIEVTHDPK 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 236 SALHGAHVVFPRNWASaallkVGasqFGKENESRlHEKHRDWMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVMDSSRS 315
Cdd:PRK00779 213 EAVKGADVVYTDVWVS-----MG---QEAEAEER-LKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQS 283

                        330       340
                 ....*....|....*....|.
gi 939572606 316 VIYDQAENGLYTKMAVLALTM 336
Cdd:PRK00779 284 VVWDEAENRLHAQKALLAWLL 304
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
10-159 7.41e-52

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 167.99  E-value: 7.41e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   10 DLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTTRLEVG 89
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   90 EAIKDVAKMYERYGHGLGVRildqaidfvyGKGNWVVRECARHAEIPVINMACCSFHPTQGLADLMTAQE 159
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIR----------HFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 5-338 1.07e-116

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 339.72  E-value: 1.07e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   5 SLYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTT 84
Cdd:COG0078    2 NLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  85 RLEVGEAIKDVAKMYERYGHGLGVRILDQAIdfvygkgnwvVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNI 164
Cdd:COG0078   82 QLGRGESIKDTARVLSRYVDGIMIRTFGHET----------LEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 165 QAKKYVIMW-----GYSrkfrgrcsiqeEMLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKSALH 239
Cdd:COG0078  152 KGLKVAYVGdgnnvANS-----------LLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVK 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 240 GAHVVFPRNWASaallkvgasqFGKENES-RLHEKHRDWMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVMDSSRSVIY 318
Cdd:COG0078  221 GADVVYTDVWVS----------MGQEEEAeERIKAFKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVF 290

                        330       340
                 ....*....|....*....|
gi 939572606 319 DQAENGLYTKMAVLALTMGE 338
Cdd:COG0078  291 DEAENRLHAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 9-337 4.02e-79

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 243.80  E-value: 4.02e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606    9 KDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTTRLEV 88
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   89 GEAIKDVAKMYERYGHGLGVRILDQAIdfvygkgnwvVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNIQAKK 168
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHED----------VEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVK 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  169 YVIMWGysrkfrGRCSIQEEMLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKSALHGAHVVFPRN 248
Cdd:TIGR00658 151 VVYVGD------GNNVCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDV 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  249 WASAALLkvgasqfgKENESRLhEKHRDWMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVMDSSRSVIYDQAENGLYTK 328
Cdd:TIGR00658 225 WVSMGEE--------DKKEERL-KLFRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQ 295


                  ....*....
gi 939572606  329 MAVLALTMG 337
Cdd:TIGR00658 296 KAVMVALLG 304
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 5-336 7.17e-77

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 238.07  E-value: 7.17e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   5 SLYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTT 84
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  85 RLEVGEAIKDVAKMYERYGHGLGVRILDQAIdfvygkgnwvVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNI 164
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHET----------LEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 165 QAKKYVIM---------WgysrkfrgrcsiqeeMLIMTRFGMDVVLAYPPGFELDQKLVDAareNAANSGGHLEVTHDYK 235
Cdd:PRK00779 151 KGLKVAWVgdgnnvansL---------------LLAAALLGFDLRVATPKGYEPDPEIVEK---IAKETGASIEVTHDPK 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 236 SALHGAHVVFPRNWASaallkVGasqFGKENESRlHEKHRDWMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVMDSSRS 315
Cdd:PRK00779 213 EAVKGADVVYTDVWVS-----MG---QEAEAEER-LKAFAPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQS 283

                        330       340
                 ....*....|....*....|.
gi 939572606 316 VIYDQAENGLYTKMAVLALTM 336
Cdd:PRK00779 284 VVWDEAENRLHAQKALLAWLL 304
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 9-333 8.51e-76

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 236.57  E-value: 8.51e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   9 KDLITTQEWAIEEIEAILDLARGFKgkyaRGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDV--STTRL 86
Cdd:PRK04523   4 KHFLNTQDWSRAELDALLTQAAAFK----RNKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLQPgkDAWPI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  87 EVG----------EAIKDVAKMYERYGHGLGVRILDQAIDFVYGKGNWVVRECARHAEIPVINMACCSfHPTQGLADLMT 156
Cdd:PRK04523  80 EFElgavmdgeteEHIREVARVLSRYVDLIGVRAFPKFVDWSKDRQDQVLNSFAKYSTVPVINMETIT-HPCQELAHALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 157 AQEKLGNI-QAKKYVIMWGYSRKFRGRCSIQEEMLIMTRFGMDVVLAYP-PGFELDQKLVDAARENAANSGGHLEVTHDY 234
Cdd:PRK04523 159 LQEHFGTTlRGKKYVLTWTYHPKPLNTAVANSALLIATRLGMDVTLLCPtPDYILDERYMDWAEQNAAESGGSLTVSHDI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 235 KSALHGAHVVFPRNWASAALlkvgasqFGK-ENESRLHEKHRDWMLTQELVDLMdKRGIITHVLPVLRGEEAEDKVMDSS 313
Cdd:PRK04523 239 DSAYAGADVVYAKSWGALPF-------FGNwEPEKPIRDQYQHFIVDERKMALT-NNGVFSHCLPLRRNVKVTDAVMDSP 310

                        330       340
                 ....*....|....*....|
gi 939572606 314 RSVIYDQAENGLYTKMAVLA 333
Cdd:PRK04523 311 NCIAIDEAENRLHVQKAIMA 330
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 5-340 3.95e-58

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 189.88  E-value: 3.95e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   5 SLYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTT 84
Cdd:COG0540    2 SFKMRHLLSIEDLSREEIEELLDTAEEFKEVLRPIKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  85 RLEVGEAIKDVAKMYERYGhglgvrildqaIDFVygkgnwVVR--------ECARHAEIPVINmac-csfHPTQGLADLM 155
Cdd:COG0540   82 SVSKGESLADTIRTLEAYG-----------ADAI------VIRhpqegaarLLAEHVDVPVINagdgaheHPTQALLDLY 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 156 TAQEKLGNIQAKKYVIMwG---YSRKFRgrcSIqeeMLIMTRFGMDVVLAYPPgfELdqklvdaARENAANSGghLEVTH 232
Cdd:COG0540  145 TIREEFGRLDGLKVAIV-GdlkHSRVAR---SN---IKALSKLGAEVTLVAPP--TL-------LPEEIEELG--VEVTT 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 233 DYKSALHGAHVVFprnwasaaLLKVGASQFGKENESRLHEKHRDWMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVMDS 312
Cdd:COG0540  207 DLDEALPDADVVY--------MLRIQKERFTDGLFPSYREYKRSYGLTAERLALAKPDAIVMHPGPRNRGVEIDSDVDDT 278

                        330       340
                 ....*....|....*....|....*...
gi 939572606 313 SRSVIYDQAENGLYTKMAVLALTMGENK 340
Cdd:COG0540  279 PRSVIFEQVTNGVAVRMALLYLLLGGEE 306
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
5-340 6.51e-56

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 184.12  E-value: 6.51e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   5 SLYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEA-PELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVST 83
Cdd:PRK00856   2 PLKMKHLLSIEDLSREEIELLLDTAEEFKEVLRREVKkVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAST 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  84 TRLEVGEAIKDVAKMYERYGhglgvrildqaIDFVygkgnwVVR--------ECARHAEIPVINmAC--CSFHPTQGLAD 153
Cdd:PRK00856  82 SSVSKGETLADTIRTLSAMG-----------ADAI------VIRhpqsgaarLLAESSDVPVIN-AGdgSHQHPTQALLD 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 154 LMTAQEKLGNIQAKKYVIMwG---YSRKFRgrcSiqeEMLIMTRFGMDVVLAYPPgfELDQKLVDAARenaansgghleV 230
Cdd:PRK00856 144 LLTIREEFGRLEGLKVAIV-GdikHSRVAR---S---NIQALTRLGAEVRLIAPP--TLLPEGMPEYG-----------V 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 231 THDYKSALHGAHVVFprnwasaaLLKVGASQFGKENESRLHEKHRDWMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVM 310
Cdd:PRK00856 204 HTDLDEVIEDADVVM--------MLRVQKERMDGGLLPSYEEYKRSYGLTAERLALAKPDAIVMHPGPVNRGVEIASDVA 275

                        330       340       350
                 ....*....|....*....|....*....|
gi 939572606 311 DSSRSVIYDQAENGLYTKMAVLALTMGENK 340
Cdd:PRK00856 276 DGPQSVIFEQVTNGVAVRMAVLELLLGGRL 305
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 6-337 2.66e-54

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 180.85  E-value: 2.66e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   6 LYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTTR 85
Cdd:PRK02102   5 LKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGPNDSQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  86 LEVGEAIKDVAKMyeryghgLGvRILDqAIDFvYGKGNWVVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNIQ 165
Cdd:PRK02102  85 LGKKESIEDTARV-------LG-RMYD-GIEY-RGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHFGPLK 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 166 AKKYVIMwGYSRKFRGRcSIqeeMLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKSALHGAHVVF 245
Cdd:PRK02102 155 GLKLAYV-GDGRNNMAN-SL---MVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIY 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 246 PRNWASaallkvgasqFGKENEsrlhEKHRDWMLT--QELVDLMDKRG----IITHVLPV-----------------LRG 302
Cdd:PRK02102 230 TDVWVS----------MGEEDE----WEERIKLLKpyQVNMDLMKATGnpdvIFMHCLPAfhdtetkvgkeiaekygLKG 295

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 939572606 303 EEAEDKVMDSSRSVIYDQAENGLYTKMAVLALTMG 337
Cdd:PRK02102 296 LEVTDEVFESKYSIVFDEAENRMHTIKAVMVATLG 330
PLN02342 PLN02342
ornithine carbamoyltransferase
 8-337 4.64e-52

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 175.36  E-value: 4.64e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   8 GKDLITTQEWAIEEIEAILDLARGFKGKYARGE-APELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTTRL 86
Cdd:PLN02342  45 PKHFLHIDDFDKEEILGLLDRAKEVKALLKSGDrSFQPFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDDIQL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  87 EVGEAIKDVAKMYERYGHGLGVRildqaidfVYGKGNwvVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNIQA 166
Cdd:PLN02342 125 GKREETRDIARVLSRYNDIIMAR--------VFAHQD--VLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEHIGRLEG 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 167 KKYVIMWGysrkfrGRCSIQEEMLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSgghLEVTHDYKSALHGAHVVFP 246
Cdd:PLN02342 195 TKVVYVGD------GNNIVHSWLLLAAVLPFHFVCACPKGYEPDAKTVEKARAAGISK---IEITNDPAEAVKGADVVYT 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 247 RNWASaallkvgasqFGKENESRLHEKHRD-WMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVMDSSRSVIYDQAENGL 325
Cdd:PLN02342 266 DVWAS----------MGQKEEAEKRKKAFQgFQVNEALMKLAGPQAYFMHCLPAERGVEVTDGVMEAPNSIVFPQAENRM 335

                        330
                 ....*....|..
gi 939572606 326 YTKMAVLALTMG 337
Cdd:PLN02342 336 HAQNAIMLHQLG 347
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
10-159 7.41e-52

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 167.99  E-value: 7.41e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   10 DLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTTRLEVG 89
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   90 EAIKDVAKMYERYGHGLGVRildqaidfvyGKGNWVVRECARHAEIPVINMACCSFHPTQGLADLMTAQE 159
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIR----------HFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 9-332 4.72e-46

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 158.70  E-value: 4.72e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   9 KDLITTQEWAIEEIEAILDLARGFKG---KYARGeapelLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTTR 85
Cdd:PRK14805   2 KHLLSIKELTQQQLLDLLALAKTIKAnpaEYRQA-----LAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  86 LEVGEAIKDVAKMYERYGHGLGVRILDQAidfvygkgnwVVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNIQ 165
Cdd:PRK14805  77 LGKRESVADFAANLSCWADAIVARVFSHS----------TIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQFGDVS 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 166 AKK--YVimwGysrkfRGRCSIQEEMLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYkSALHGAHV 243
Cdd:PRK14805 147 KVKlaYV---G-----DGNNVTHSLMYGAAILGATMTVICPPGHFPDGQIVAEAQELAAKSGGKLVLTSDI-EAIEGHDA 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 244 VFPRNWASAAllkvgasqfgkeNESRLHEKHRDWMLTQELVDLMDKRGI--ITHVLPVLRGEEAEDKVMDSSRSVIYDQA 321
Cdd:PRK14805 218 IYTDTWISMG------------DDTPLAEIKAKFAPYQVNKALMEKAGAtfVMHCQPAHRGVEITSEVMDGEGSLILQQA 285

                        330
                 ....*....|.
gi 939572606 322 ENGLYTKMAVL 332
Cdd:PRK14805 286 ENRMHAQNAVL 296
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 4-321 1.80e-44

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 156.82  E-value: 1.80e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   4 DSLYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVST 83
Cdd:PRK07200  16 SHMHEKDFLLTWEKTPDELKAVLDVADALRALREENISTKVFNSGLGISVFRDNSTRTRFSYASACNLLGLEVQDLDEGK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  84 TRLEVGEAIKDVAKMYERYGHGLGVRilDqaiDFVYGKGNWVVRECARHAE-------IP----VINMACCSFHPTQGLA 152
Cdd:PRK07200  96 SQIAHGETVRETANMISFMADVIGIR--D---DMYIGKGNAYMREVGAAVDdgykqgvLPqrptLVNLQCDIDHPTQSMA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 153 DLMTAQEKLG---NIQAKKYVIMWGYSRKFRGRCSI-QEEMLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSGGHL 228
Cdd:PRK07200 171 DLLHLIEHFGgleNLKGKKIAMTWAYSPSYGKPLSVpQGIIGLMTRFGMDVTLAHPEGYDLMPEVVEVAKKNAKASGGSF 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 229 EVTHDYKSALHGAHVVFPRNWASAA-------LLKVGASQFGKENESRLHE---KHRDWMLTQELVDLM-DKRGIITHVL 297
Cdd:PRK07200 251 RQVNSMEEAFKDADIVYPKSWAPYKvmeerteLYRAGDHEGIKALEKELLAqnaQHKDWHCTEEMMKLTkDGKALYMHCL 330

                        330       340       350
                 ....*....|....*....|....*....|
gi 939572606 298 PV------LRGEEAEDKVMDSSRSVIYDQA 321
Cdd:PRK07200 331 PAdisgvsCKEGEVTESVFDRYRIALYKEA 360
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
189-335 2.38e-44

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 149.30  E-value: 2.38e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  189 MLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKSALHGAHVVFPRNWASAAllkvgasqFGKENES 268
Cdd:pfam00185  17 IIAAAKLGMDVRLATPKGYPPDPEVLDKAKKIAEKSGGSIEITDDPAEAVKGADVVYTDVWQSMG--------QEKEREE 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 939572606  269 RLhEKHRDWMLTQELVDLMDKRGIITHVLPVLRGEEAEDKVMDSSRSVIYDQAENGLYTKMAVLALT 335
Cdd:pfam00185  89 RL-KAFKPYQVNEELMKLAKKDAIFMHCLPAHRGEEVTDDVFDGPRSVVFDQAENRLHAQKALLALL 154
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 9-337 1.89e-41

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 146.35  E-value: 1.89e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606    9 KDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHA-QFIDVSTTRLE 87
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKEPLKLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVvNFSDSETSSVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   88 VGEAIKDVAKMYERYGHGLGVRILDQAidfvygkgnwVVRECARHAEIPVINMA-CCSFHPTQGLADLMTAQEKLGNIQA 166
Cdd:TIGR00670  81 KGETLADTIKTLSGYVDAIVIRHPLEG----------AARLAAEVSEVPVINAGdGSNQHPTQTLLDLYTIYEEFGRLDG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  167 KKYVIMwG---YSRkfrgrcSIQEEMLIMTRFGMDVVLAYPPGFELDQKLVDAARENaansGGHLEVTHDYKSALHGAHV 243
Cdd:TIGR00670 151 LKIALV-GdlkYGR------TVHSLAEALTRFGVEVYLISPEELRMPKEILEELKAK----GIKVRETESLEEVIDEADV 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  244 VFprnwasaaLLKVGASQFGKENEsrLHEKHRDWMLTQELVDLMDKRGIITHVLPvlRGEEAEDKVMDSSRSVIYDQAEN 323
Cdd:TIGR00670 220 LY--------VTRIQKERFPDPEE--YEKVKGSYGITLERLEAAKKGVIIMHPLP--RVDEIDPSVDDTPHAKYFKQAFN 287

                         330
                  ....*....|....
gi 939572606  324 GLYTKMAVLALTMG 337
Cdd:TIGR00670 288 GVPVRMALLALLLG 301
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 3-338 8.23e-36

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 132.17  E-value: 8.23e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   3 QDSLYGKDLITTQEWAIEEIEAILDLARGFK-GKYARGEAPELlRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDV 81
Cdd:PRK04284   1 MKNLRNRSFLTLLDFTPKEIEYLLDLSEDLKrAKYAGIEVQKL-KGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  82 STTRLEVGEAIKDVAKMYERYGHGLGVRILDQAIdfvygkgnwvVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKL 161
Cdd:PRK04284  80 TGSQMGKKESTKDTARVLGGMYDGIEYRGFSQRT----------VETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 162 -GNIQAKKYVIMWGysrkfrGRCSIQEEML----IMtrfGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKS 236
Cdd:PRK04284 150 kKPYKDIKFTYVGD------GRNNVANALMqgaaIM---GMDFHLVCPKELNPDDELLNKCKEIAAETGGKITITDDIDE 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 237 ALHGAHVVFPRNWASaallkVGASQFGKENESRLHEKHRdwmLTQELVDLM-DKRGIITHVLPV---------------- 299
Cdd:PRK04284 221 GVKGSDVIYTDVWVS-----MGEPDEVWEERIKLLKPYQ---VNKEMMKKTgNPNAIFEHCLPSfhdldtkvgkeifeky 292

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 939572606 300 -LRGEEAEDKVMDSSRSVIYDQAENGLYTKMAVLALTMGE 338
Cdd:PRK04284 293 gLKEMEVTDEVFESKASVVFDEAENRMHTIKAVMVATLGE 332
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 21-336 1.38e-33

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 126.64  E-value: 1.38e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  21 EIEAILDLARGFK-GKYARGEAPELlRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTTRLEVGEAIKDVAKMY 99
Cdd:PRK01713  20 EIKYLLDLSRDLKrAKYAGTEQQRL-KGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDPNSSQIGHKESMKDTARVL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 100 ERYGHGLGVRILDQAIdfvygkgnwvVRECARHAEIPVINMACCSFHPTQGLADLMTAQEK----LGNIqakKYVIMwGY 175
Cdd:PRK01713  99 GRMYDAIEYRGFKQSI----------VNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENcdkpLSEI---SYVYI-GD 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 176 SRKFRGrcsiQEEMLIMTRFGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKSALHGAHVVFPRNWASaall 255
Cdd:PRK01713 165 ARNNMG----NSLLLIGAKLGMDVRICAPKALLPEASLVEMCEKFAKESGARITVTDDIDKAVKGVDFVHTDVWVS---- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 256 kvgasqFGKENESrLHEKHRDWMLTQELVDLMDKRG----IITHVLPVLR-------------------GEEAEDKVMDS 312
Cdd:PRK01713 237 ------MGEPLET-WGERIKLLMPYQVTPELMKRTGnpkvKFMHCLPAFHnsetkvgrqiaekypelanGIEVTEDVFES 309

                        330       340
                 ....*....|....*....|....
gi 939572606 313 SRSVIYDQAENGLYTKMAVLALTM 336
Cdd:PRK01713 310 PMNIAFEQAENRMHTIKAVMVASL 333
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 5-338 1.26e-31

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 121.32  E-value: 1.26e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   5 SLYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTT 84
Cdd:PRK12562   3 GFYKKHFLKLLDFTPAELNSLLQLAAKLKADKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  85 RLEVGEAIKDVAKMYERYGHGLGVRildqaidfvyGKGNWVVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKL-GN 163
Cdd:PRK12562  83 QIGHKESIKDTARVLGRMYDGIQYR----------GHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLpGK 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 164 IQAKKYVIMWGYSRKFRGRCSIQEEMLImtrfGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKSALHGAHV 243
Cdd:PRK12562 153 AFNEMTLVYAGDARNNMGNSMLEAAALT----GLDLRLVAPQACWPEASLVAECSALAQKHGGKITLTEDIAAGVKGADF 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 244 VFPRNWASaallkVGASqfgKENESRLHEKHRDWMLTQELVDLMDKRGI-ITHVLPVLR------------------GEE 304
Cdd:PRK12562 229 IYTDVWVS-----MGEP---KEKWAERIALLRGYQVNSKMMALTGNPQVkFLHCLPAFHddqttlgkkmakefglhgGME 300

                        330       340       350
                 ....*....|....*....|....*....|....
gi 939572606 305 AEDKVMDSSRSVIYDQAENGLYTKMAVLALTMGE 338
Cdd:PRK12562 301 VTDEVFESPASIVFDQAENRMHTIKAVMVATLAK 334
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 6-339 2.17e-31

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 120.59  E-value: 2.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   6 LYGKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTTR 85
Cdd:PRK03515   4 FYQRHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  86 LEVGEAIKDVAKMYERYGHGLGVRildqaidfvyGKGNWVVRECARHAEIPVINMACCSFHPTQGLADLMTAQEKLGNIQ 165
Cdd:PRK03515  84 IGHKESIKDTARVLGRMYDGIQYR----------GYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 166 AKK----YVimwGYSRKFRGRCSIQEEMLImtrfGMDVVLAYPPGFELDQKLVDAARENAANSGGHLEVTHDYKSALHGA 241
Cdd:PRK03515 154 FNEmtlaYA---GDARNNMGNSLLEAAALT----GLDLRLVAPKACWPEAALVTECRALAQKNGGNITLTEDIAEGVKGA 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 242 HVVFPRNWASAAllkvgasqfgkENESRLHEK---HRDWMLTQELVDLMDKRGI-ITHVLPVLR---------------- 301
Cdd:PRK03515 227 DFIYTDVWVSMG-----------EPKEVWAERialLRPYQVNSKMMQLTGNPQVkFLHCLPAFHddqttlgkkmaeeygl 295

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 939572606 302 --GEEAEDKVMDSSRSVIYDQAENGLYTKMAVLALTMGEN 339
Cdd:PRK03515 296 hgGMEVTDEVFESAHSIVFDQAENRLHTIKAVMVATLSKD 335
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 9-332 1.82e-22

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 95.86  E-value: 1.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   9 KDLITTQEWAIEEIEAILDLARGFKGKyaRGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFID-------V 81
Cdd:PRK14804   7 KHLISWEDWSDSEILDLLDFAVHVKKN--RVNYAGHMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDwmasnfqL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  82 STTRLEVGEAIKDVAKMYERyghglgvriLDQAIDFVYGKGNwvvrecarhAEIPVINMACCSFHPTQGLADLMTAQEKL 161
Cdd:PRK14804  85 SDIDLEARYLSRNVSVIMAR---------LKKHEDLLVMKNG---------SQVPVINGCDNMFHPCQSLADIMTIALDS 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 162 GNIQAKKYVIMW-GYSRKFrgrcsIQEEMLIMTRFGMDVVLAYPpgFELDQKLVDAARENaANSGGHLEVTHDYKSALHG 240
Cdd:PRK14804 147 PEIPLNQKQLTYiGVHNNV-----VNSLIGITAALGIHLTLVTP--IAAKENIHAQTVER-AKKKGTLSWEMNLHKAVSH 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 241 AHVVFPRNWASAALLKvgASQFGKENESRLHEKhrdwMLTQELVDLMDK-RGIITHVLPVLRGEEAEDKVMDSSRSVIYD 319
Cdd:PRK14804 219 ADYVYTDTWLDMEFFN--DPSYADKKKQRMELM----MPYQINSSLMEKtNAKVMHDMPIHAGYEITREVVLSDRSIIFQ 292

                        330
                 ....*....|...
gi 939572606 320 QAENGLYTKMAVL 332
Cdd:PRK14804 293 QAENRLDAQKAVI 305
PLN02527 PLN02527
aspartate carbamoyltransferase
 9-337 1.36e-21

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 93.27  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   9 KDLITTQEWAIEEIEAILDLARGFKgkYARGEAPELLRRKTFFM--LFYAPSTRTRAAFEAAMTILGGhaQFIDVSTTR- 85
Cdd:PLN02527   1 SDVIEAQQFDREMLELLFEVAREME--KVERGSPGSQMLKGYLMatLFYEPSTRTRLSFESAMKRLGG--EVLTTENAGe 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  86 ---LEVGEAIKDVAKMYERYGHGLGVRildqaiDFVYGKgnwvVRECARHAEIPVINMA-CCSFHPTQGLADLMTAQEKL 161
Cdd:PLN02527  77 fssAAKGETLEDTIRTVEGYSDIIVLR------HFESGA----ARRAAATAEIPVINAGdGPGQHPTQALLDVYTIQREI 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 162 GNIQAKKyVIMWG---YSRKFRGRCSiqeemlIMTRFGmDVVLAY--PPGFeldqKLVDAARENAANSGGHLEVTHDYKS 236
Cdd:PLN02527 147 GRLDGIK-VGLVGdlaNGRTVRSLAY------LLAKYE-DVKIYFvaPDVV----KMKDDIKDYLTSKGVEWEESSDLME 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 237 ALHGAHVVFprnwasaaLLKVGASQFGKENEsrLHEKHR-DWMLTQELVDLMDKRGIITHVLPvlRGEEAEDKVMDSSRS 315
Cdd:PLN02527 215 VASKCDVLY--------QTRIQRERFGERID--LYEAARgKYIVDKKVMDVLPKHAVVMHPLP--RLDEITTDVDSDPRA 282

                        330       340
                 ....*....|....*....|..
gi 939572606 316 VIYDQAENGLYTKMAVLALTMG 337
Cdd:PLN02527 283 AYFRQAKNGLFIRMALLKLLLG 304
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 3-337 2.86e-20

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 91.08  E-value: 2.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   3 QDSLYGK-DLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHA-QFID 80
Cdd:PRK11891  81 QFAFEGKpQLLSVDQFSRDSVEALFRVADVMQPIARRQKISRVLEGAVLGNLFFEASTRTRVSFGAAFCRLGGSVcDTTG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  81 VSTTRLEVGEAIKDVAKMYERYGHGLGVRILDQAidfvygkgnwVVRECARHAEIPVINMACCSF-HPTQGLADLMTAQE 159
Cdd:PRK11891 161 FTFSSMAKGESIYDTSRVMSGYVDALVIRHPEQG----------SVAEFARATNLPVINGGDGPGeHPSQALLDLYTIQR 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 160 ---KLGNIQAKKYVIMWGYSRKFRGRCSIQeEMLIMTRfGMDVVLAYPPGFELDQKLVDAARENaansgGH-LEVTHDYK 235
Cdd:PRK11891 231 efsRLGKIVDGAHIALVGDLKYGRTVHSLV-KLLALYR-GLKFTLVSPPTLEMPAYIVEQISRN-----GHvIEQTDDLA 303

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 236 SALHGAHVVFprnwasaallkvgASQFGKE---NESrLHEKHRDWMLTQELVDLMDKRG-IITHVLPVLRGEEAEDKVMD 311
Cdd:PRK11891 304 AGLRGADVVY-------------ATRIQKErfaDES-FEGYTPDFQINQALVDAVCKPDtLIMHPLPRDSRPGANDLSTD 369

                        330       340
                 ....*....|....*....|....*....
gi 939572606 312 ---SSRSVIYDQAENGLYTKMAVLALTMG 337
Cdd:PRK11891 370 lnrDPRLAIFRQTDNGIPVRMAIFAVLLG 398
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 8-337 2.48e-16

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 78.62  E-value: 2.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606   8 GKDLITTQEWAIEEIEAILDLARGFKGKYARGEAPELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGH-AQFIDVSTTRL 86
Cdd:PRK08192   5 GSHILSVNQLDRDAIQRIFNVADRMEPYALREKRTRVLEGAILGNLFFEPSTRTRVSFGCAFNLLGGHvRETTGMASSSL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  87 EVGEAIKDVAKMYERYGHGLGVRILDQaidfvygkgnWVVRECARHAEIPVINMACCSF-HPTQGLADLMTAQEKL---- 161
Cdd:PRK08192  85 SKGESLYDTARVLSTYSDVIAMRHPDA----------GSVKEFAEGSRVPVINGGDGSNeHPTQALLDLFTIQKELahag 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 162 GNIQAkKYVIMWGySRKFrGRCSIQEEMLIMTRFGMDVVLAYPPGFELDQKLVDAARenaaNSGGHLEVTHDYKSALHGA 241
Cdd:PRK08192 155 RGIDG-MHIAMVG-DLKF-GRTVHSLSRLLCMYKNVSFTLVSPKELAMPDYVISDIE----NAGHKITITDQLEGNLDKA 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 242 HVVFprnwasaaLLKVGASQFGKENESRLHEKHrdWMLTQEL-VDLMDKRGIITHVLPVLRGEEAE--DKVMDSSRSV-I 317
Cdd:PRK08192 228 DILY--------LTRIQEERFPSQEEANKYRGK--FRLNQSIyTQHCKSNTVIMHPLPRDSRAQANelDNDLNSHPNLaI 297

                        330       340
                 ....*....|....*....|
gi 939572606 318 YDQAENGLYTKMAVLALTMG 337
Cdd:PRK08192 298 FRQADNGLLIRMALFALTLG 317
pyrB PRK13814
aspartate carbamoyltransferase;
43-334 2.17e-07

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 51.64  E-value: 2.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606  43 ELLRRKTFFMLFYAPSTRTRAAFEAAMTILGGHAQFIDVSTTRLEVGEAIKDVAKMYEryghGLGVRILdqaidFVYGKG 122
Cdd:PRK13814  41 ETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISAISKGETLFDTIKTLE----AMGVYFF-----IVRHSE 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 123 NWVVRECARH-AEIPVINMACCSF-HPTQGLADLMTAQEKLGNIQaKKYVIMWGYSRKFRGRCSIQEEMLIMtrfGM-DV 199
Cdd:PRK13814 112 NETPEQIAKQlSSGVVINAGDGNHqHPSQALIDLMTIKQHKPHWN-KLCVTIIGDIRHSRVANSLMDGLVTM---GVpEI 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939572606 200 VLAYPPGFELDQKLVDAARENAansgghlevthDYKSALHGAHVVfprnwasaALLKVGASQfgKENESRLHEKHRDWML 279
Cdd:PRK13814 188 RLVGPSSLLPDKVGNDSIKKFT-----------ELKPSLLNSDVI--------VTLRLQKER--HDNSVDIDAFRGSFRL 246

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 939572606 280 TQELVDLMDKRGIITHVLPVLRGEEAEDKVMDSSRSVIYDQAENGLYTKMAVLAL 334
Cdd:PRK13814 247 TPEKLYSAKPDAIVMHPGPVNREVEINSDVADNQQSVILQQVRNGVAMRMAVLEL 301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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