arginase [Vibrio cholerae O1 str. KW3]
Protein Classification
arginase family protein( domain architecture ID 98571)
arginase family protein is a metal-dependent enzyme that catalyzes the hydrolysis of an amide bond, such as arginase-like amidino hydrolases and histone/histone-like deacetylases
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| Arginase_HDAC super family | cl17011 | Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily ... |
52-245 | 2.33e-07 | ||||
Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily includes metal-dependent enzymes that belong to Arginase-like amidino hydrolase family and histone/histone-like deacetylase class I, II, IV family, respectively. These enzymes catalyze hydrolysis of amide bond. Arginases are known to be involved in control of cellular levels of arginine and ornithine, in histidine and arginine degradation and in clavulanic acid biosynthesis. Deacetylases play a role in signal transduction through histone and/or other protein modification and can repress/activate transcription of a number of different genes. They participate in different cellular processes including cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and post-translational control of the acetyl coenzyme A synthetase. Mammalian histone deacetyases are known to be involved in progression of different tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs. The actual alignment was detected with superfamily member cd09988: Pssm-ID: 450134 [Multi-domain] Cd Length: 262 Bit Score: 50.59 E-value: 2.33e-07
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| Name | Accession | Description | Interval | E-value | ||||
| Formimidoylglutamase | cd09988 | Formimidoylglutamase or HutE; Formimidoylglutamase (N-formimidoyl-L-glutamate ... |
52-245 | 2.33e-07 | ||||
Formimidoylglutamase or HutE; Formimidoylglutamase (N-formimidoyl-L-glutamate formimidoylhydrolase; formiminoglutamase; N-formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase; HutE; EC 3.5.3.8) is a metalloenzyme that catalyzes hydrolysis of N-formimidoyl-L-glutamate to L-glutamate and formamide. This enzyme is involved in histidine degradation, requiring Mn as a cofactor while glutathione may be required for maximal activity. In Pseudomonas PAO1, mutation studies show that histidine degradation proceeds via a 'four-step' pathway if the 'five-step' route is absent and vice versa; in the four-step pathway, formiminoglutaminase (HutE, EC 3.5.3.8) directly converts formiminoglutamate (FIGLU) to L-glutamate and formamide in a single step. Formiminoglutamase has traditionally also been referred to as HutG; however, formiminoglutamase is structurally and mechanistically unrelated to N-formyl-glutamate deformylase (also called HutG). Phylogenetic analysis has suggested that HutE was acquired by horizontal gene transfer from a Ralstonia-like ancestor. Pssm-ID: 212514 [Multi-domain] Cd Length: 262 Bit Score: 50.59 E-value: 2.33e-07
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| SpeB | COG0010 | Arginase/agmatinase family enzyme [Amino acid transport and metabolism]; Arginase/agmatinase ... |
72-243 | 2.08e-05 | ||||
Arginase/agmatinase family enzyme [Amino acid transport and metabolism]; Arginase/agmatinase family enzyme is part of the Pathway/BioSystem: Urea cycle Pssm-ID: 439781 [Multi-domain] Cd Length: 283 Bit Score: 44.82 E-value: 2.08e-05
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| Name | Accession | Description | Interval | E-value | ||||
| Formimidoylglutamase | cd09988 | Formimidoylglutamase or HutE; Formimidoylglutamase (N-formimidoyl-L-glutamate ... |
52-245 | 2.33e-07 | ||||
Formimidoylglutamase or HutE; Formimidoylglutamase (N-formimidoyl-L-glutamate formimidoylhydrolase; formiminoglutamase; N-formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase; HutE; EC 3.5.3.8) is a metalloenzyme that catalyzes hydrolysis of N-formimidoyl-L-glutamate to L-glutamate and formamide. This enzyme is involved in histidine degradation, requiring Mn as a cofactor while glutathione may be required for maximal activity. In Pseudomonas PAO1, mutation studies show that histidine degradation proceeds via a 'four-step' pathway if the 'five-step' route is absent and vice versa; in the four-step pathway, formiminoglutaminase (HutE, EC 3.5.3.8) directly converts formiminoglutamate (FIGLU) to L-glutamate and formamide in a single step. Formiminoglutamase has traditionally also been referred to as HutG; however, formiminoglutamase is structurally and mechanistically unrelated to N-formyl-glutamate deformylase (also called HutG). Phylogenetic analysis has suggested that HutE was acquired by horizontal gene transfer from a Ralstonia-like ancestor. Pssm-ID: 212514 [Multi-domain] Cd Length: 262 Bit Score: 50.59 E-value: 2.33e-07
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| SpeB | COG0010 | Arginase/agmatinase family enzyme [Amino acid transport and metabolism]; Arginase/agmatinase ... |
72-243 | 2.08e-05 | ||||
Arginase/agmatinase family enzyme [Amino acid transport and metabolism]; Arginase/agmatinase family enzyme is part of the Pathway/BioSystem: Urea cycle Pssm-ID: 439781 [Multi-domain] Cd Length: 283 Bit Score: 44.82 E-value: 2.08e-05
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