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Conserved domains on  [gi|937925993|dbj|BAT00910|]
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Os07g0264800 [Oryza sativa Japonica Group]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 200-285 3.72e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 63.91  E-value: 3.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993 200 DEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMALRAYKDDDGARGLYSKAGYRVVAKDPGWVTWvgrrRRVL 279
Cdd:COG0456   11 GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGD----DALV 86


                 ....*.
gi 937925993 280 MIKELP 285
Cdd:COG0456   87 MEKELA 92
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 200-285 3.72e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 63.91  E-value: 3.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993 200 DEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMALRAYKDDDGARGLYSKAGYRVVAKDPGWVTWvgrrRRVL 279
Cdd:COG0456   11 GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGD----DALV 86


                 ....*.
gi 937925993 280 MIKELP 285
Cdd:COG0456   87 MEKELA 92
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 176-259 6.06e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 58.68  E-value: 6.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993  176 EKIVGVVDCTVQNEADilknlqgvdEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMALRAYKDDDGARGLYS 255
Cdd:pfam00583  42 GELVGFASLSIIDDEP---------PVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYE 112


                  ....
gi 937925993  256 KAGY 259
Cdd:pfam00583 113 KLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 176-241 1.02e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 45.34  E-value: 1.02e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 937925993 176 EKIVGVVDCTVQNEADilknlqgvdEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMAL 241
Cdd:cd04301    8 GEIVGFASLSPDGSGG---------DTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 200-285 3.72e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 63.91  E-value: 3.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993 200 DEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMALRAYKDDDGARGLYSKAGYRVVAKDPGWVTWvgrrRRVL 279
Cdd:COG0456   11 GDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGD----DALV 86


                 ....*.
gi 937925993 280 MIKELP 285
Cdd:COG0456   87 MEKELA 92
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
142-284 1.94e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 60.87  E-value: 1.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993 142 SALIYRVRNSPPDRYaCLVAEEVDatsqiseapfeKIVGVVDCTVQNeadilknLQGVDEYLYVSGIAVLPSFRRRKVGT 221
Cdd:COG3153   26 AELVDRLREDPAAGL-SLVAEDDG-----------EIVGHVALSPVD-------IDGEGPALLLGPLAVDPEYRGQGIGR 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 937925993 222 ALLKACEALALQWRHRFMALRAykdDDGARGLYSKAGYRVVAKDpgwvTWVGRRRRVLMIKEL 284
Cdd:COG3153   87 ALMRAALEAARERGARAVVLLG---DPSLLPFYERFGFRPAGEL----GLTLGPDEVFLAKEL 142
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 176-259 6.06e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 58.68  E-value: 6.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993  176 EKIVGVVDCTVQNEADilknlqgvdEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMALRAYKDDDGARGLYS 255
Cdd:pfam00583  42 GELVGFASLSIIDDEP---------PVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYE 112


                  ....
gi 937925993  256 KAGY 259
Cdd:pfam00583 113 KLGF 116
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
200-276 1.04e-09

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 54.14  E-value: 1.04e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 937925993 200 DEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMALRAYKDDDGARGLYSKAGYRVVAKdpgWVTWVGRRR 276
Cdd:COG3393   13 PGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGE---YATVLFRKP 86
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 200-285 1.84e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 55.00  E-value: 1.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993 200 DEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMALRAYkddDGARGLYSKAGYRVVAKDPGWVTWVGRRRRVL 279
Cdd:COG1246   50 EDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTT---SAAIHFYEKLGFEEIDKEDLPYAKVWQRDSVV 126


                 ....*.
gi 937925993 280 MIKELP 285
Cdd:COG1246  127 MEKDLE 132
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 200-284 6.77e-09

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 53.52  E-value: 6.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993 200 DEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMALRAYKDDDGARGLYSKAGYRVVAKdpgwvtwVGRRRRVL 279
Cdd:COG0454   56 DKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGFKEIER-------YVAYVGGE 128


                 ....*
gi 937925993 280 MIKEL 284
Cdd:COG0454  129 FEKEL 133
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 154-261 1.77e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 50.92  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993  154 DRYACLVAEEVDatsqiseapfeKIVGVVDCTVQNEADILKNLqgvdeylyvsGIAVLPSFRRRKVGTALLKACEALALQ 233
Cdd:pfam13508   1 PGGRFFVAEDDG-----------KIVGFAALLPLDDEGALAEL----------RLAVHPEYRGQGIGRALLEAAEAAAKE 59

                          90       100
                  ....*....|....*....|....*...
gi 937925993  234 WRHRFMALRAYKDddgARGLYSKAGYRV 261
Cdd:pfam13508  60 GGIKLLELETTNR---AAAFYEKLGFEE 84
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
147-284 3.99e-07

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 48.84  E-value: 3.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993 147 RVRNSPPDRYACLVAEEvDatsqiseapfEKIVGVVDCTVQNEADilknlqgVDEYLYVSGIAVLPSFRRRKVGTALLKA 226
Cdd:COG1247   43 WFAAILAPGRPVLVAEE-D----------GEVVGFASLGPFRPRP-------AYRGTAEESIYVDPDARGRGIGRALLEA 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 937925993 227 CEALALQWRHRFMALRAYKDDDGARGLYSKAGYRVVAKDPGWVTWVGRRR-RVLMIKEL 284
Cdd:COG1247  105 LIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPEVGFKFGRWLdLVLMQKRL 163
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 176-241 1.02e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 45.34  E-value: 1.02e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 937925993 176 EKIVGVVDCTVQNEADilknlqgvdEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMAL 241
Cdd:cd04301    8 GEIVGFASLSPDGSGG---------DTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 176-262 1.85e-05

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 43.41  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937925993  176 EKIVGVVdctvqneadilknlqGVDEYLYVSGIAVLPSFRRRKVGTALLKACEALALQW--RHRFMALRAykdDDGARGL 253
Cdd:pfam13673  40 GQIVGVI---------------ALRDRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDgiKLSELTVNA---SPYAVPF 101


                  ....*....
gi 937925993  254 YSKAGYRVV 262
Cdd:pfam13673 102 YEKLGFRAT 110
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
200-262 7.62e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 41.71  E-value: 7.62e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 937925993 200 DEYLYVSGIAVLPSFRRRKVGTALLKACEALALQWRHRFMAL--RAYkdddgARGLYSKAGYRVV 262
Cdd:COG2153   56 DGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLsaQAH-----AVGFYEKLGFVPV 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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