|
Name |
Accession |
Description |
Interval |
E-value |
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
300-742 |
1.43e-157 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 464.44 E-value: 1.43e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 300 SLQVTFTLIFLVVAMLLLLAAVWAGLNFATRLVRPISALIGAAERVRAGDLTVRVSEPpGEDEFVLLSRAFNRMTTEIEG 379
Cdd:COG5000 2 GLQILFLLLLLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVT-GDDEIGELARAFNRMTDQLKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 380 QRRELlstnrllDERRRFTETVLSGVSAGVLGLDADGVINLPNLSAARLLDEeDPDRMVGMPLVELLPDMgDLLENAPKR 459
Cdd:COG5000 81 QREEL-------EERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGI-PLEELIGKPLEELLPEL-DLAELLREA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 460 PGRVVQDQIQIRRPGKptLTLLVRIAAEVrggdVRGYVVTFDDITELVSAQRKAAWADVARRIAHEIKNPLTPIQLSAER 539
Cdd:COG5000 152 LERGWQEEIELTRDGR--RTLLVRASPLR----DDGYVIVFDDITELLRAERLAAWGELARRIAHEIKNPLTPIQLSAER 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 540 LRRKYLKEISSDTEVFTMCTDTIVRQVDDIRRMVDEFSAFARMPQPVMKPVNINDLVRQAVFLQSSAHSGK-IRFETRLP 618
Cdd:COG5000 226 LRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEPALKEKdIRLELDLD 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 619 QGPLTVACDSRQISQALTNLLQNAADAIEGRtppaeggelppGEVSIAVEDDGERVVVTVEDNGRGLPgGEQRDRLTEPY 698
Cdd:COG5000 306 PDLPEVLADRDQLEQVLINLLKNAIEAIEEG-----------GEIEVSTRREDGRVRIEVSDNGPGIP-EEVLERIFEPF 373
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 933521231 699 VTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:COG5000 374 FTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGG-GTTFTIRLP 416
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
391-742 |
7.75e-70 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 233.59 E-value: 7.75e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 391 LDERRRFTETVLSGVSAGVLGLDADGVINLPNLSAARLLdEEDPDRMVGMPLVELLPDMG---DLLENAPKRPGRVVQDQ 467
Cdd:COG3852 2 LRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLL-GLSAEELLGRPLAELFPEDSplrELLERALAEGQPVTERE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 468 IQIRRPGKPTLTLLVRIAAEVRGGDVRGYVVTFDDITELVSAQRKAAWAD-------VARRIAHEIKNPLTPIQLSAERL 540
Cdd:COG3852 81 VTLRRKDGEERPVDVSVSPLRDAEGEGGVLLVLRDITERKRLERELRRAEklaavgeLAAGLAHEIRNPLTGIRGAAQLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 541 RRKyLKEiSSDTEVftmcTDTIVRQVDDIRRMVDEFSAFARMPQPVMKPVNINDLVRQAVFLQSSAHSGKIRFETRLPQG 620
Cdd:COG3852 161 ERE-LPD-DELREY----TQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEAPKNIRIVRDYDPS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 621 PLTVACDSRQISQALTNLLQNAADAIEgrtppaEGGELppgEVSIAVED--------DGERVVVTVEDNGRGLPgGEQRD 692
Cdd:COG3852 235 LPEVLGDPDQLIQVLLNLVRNAAEAMP------EGGTI---TIRTRVERqvtlgglrPRLYVRIEVIDNGPGIP-EEILD 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 933521231 693 RLTEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:COG3852 305 RIFEPFFTTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGK-GTTFRIYLP 353
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
389-742 |
9.68e-54 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 190.01 E-value: 9.68e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 389 RLLDERRRFTETVLSGVSAGVLGLDADGVINLPNLSAARLLDEEDPDRMVGMPLVELLPDMGDLLENAPKRPGRVVQDQI 468
Cdd:COG4191 2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 469 QIRRPGKPTLTLLVRIAAEVRGGDVRGYVVTFDDITELVSA--QRKAAWADVARR------------IAHEIKNPLTPIQ 534
Cdd:COG4191 82 LGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAeeELRELQEQLVQSeklaalgelaagIAHEINNPLAAIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 535 LSAERLRRKYlkEISSDTEVFTMCTDTIVRQVDDIRRMVDEFSAFARMPQPVMKPVNINDLVRQAV-FLQSSAHSGKIRF 613
Cdd:COG4191 162 GNAELLRRRL--EDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALeLLRPRLKARGIEV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 614 ETRLPQGPLTVACDSRQISQALTNLLQNAADAIEGRtppaeggelPPGEVSIAVEDDGERVVVTVEDNGRGLPgGEQRDR 693
Cdd:COG4191 240 ELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEG---------EGGRITISTRREGDYVVISVRDNGPGIP-PEVLER 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 933521231 694 LTEPYVTTRA--KGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:COG4191 310 IFEPFFTTKPvgKGTGLGLSISYGIVEKHGGRIEVESEPGG-GTTFTITLP 359
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
349-742 |
1.08e-51 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 190.56 E-value: 1.08e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 349 DLTVRVsePPGEDEFVLLSRAFNRMTteiegqrrellstNRLLDERRrFTETVLSGVSAGVLGLDADGVINLPNlSAARL 428
Cdd:PRK11360 231 DLSTRL--PPLPGELGEISQAINNLA-------------QALRETRS-LNELILESIADGVIAIDRQGKITTMN-PAAEV 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 429 LDEEDPDRMVGMPLVELLP---DMGDLLENApKRPGRVVQDQiQIRRPGKP-TLTLLV--RIAAEVRGgDVRGYVVTFDD 502
Cdd:PRK11360 294 ITGLQRHELVGKPYSELFPpntPFASPLLDT-LEHGTEHVDL-EISFPGRDrTIELSVstSLLHNTHG-EMIGALVIFSD 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 503 ITELVSAQRK-------AAWADVARRIAHEIKNPLTPIQLSAERLRRKYLKEISSDTevftmcTDTIVRQVDDIRRMVDE 575
Cdd:PRK11360 371 LTERKRLQRRvarqerlAALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEY------LSVVLREVDRLNKVIDQ 444
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 576 FSAFARMPQPVMKPVNINDLVRQAVFL-QSSAHSGKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAIEGRtppae 654
Cdd:PRK11360 445 LLEFSRPRESQWQPVSLNALVEEVLQLfQTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISAR----- 519
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 655 ggelppGEVSIAVEDDGE-RVVVTVEDNGRGLPGgEQRDRLTEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGt 733
Cdd:PRK11360 520 ------GKIRIRTWQYSDgQVAVSIEDNGCGIDP-ELLKKIFDPFFTTKAKGTGLGLALSQRIINAHGGDIEVESEPGV- 591
|
....*....
gi 933521231 734 GARVTLVVP 742
Cdd:PRK11360 592 GTTFTLYLP 600
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
407-742 |
3.05e-47 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 170.86 E-value: 3.05e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 407 AGVLGLDADGVINLPNLSAARLLDEEDPDRMVGMPLVELLPDMGDLLENAPKRPGRVVQDQIQIRRPGKPTLTLLVRIAA 486
Cdd:COG0642 2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 487 EVRGGDVRGYVVTFDDITELVSAQRKAAWADVARRIAHEIKNPLTPIQLSAERLRRKYLKEISSDTEvftmctdTIVRQV 566
Cdd:COG0642 82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLE-------TILRSA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 567 DDIRRMVDEFSAFARM----PQPVMKPVNINDLVRQAV-FLQSSAHSGKIRFETRLPQGPLTVACDSRQISQALTNLLQN 641
Cdd:COG0642 155 DRLLRLINDLLDLSRLeagkLELEPEPVDLAELLEEVVeLFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSN 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 642 AADAiegrTPPAeggelppGEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVTT----RAKGTGLGLAIVKKIM 717
Cdd:COG0642 235 AIKY----TPEG-------GTVTVSVRREGDRVRISVEDTGPGIPP-EDLERIFEPFFRTdpsrRGGGTGLGLAIVKRIV 302
|
330 340
....*....|....*....|....*
gi 933521231 718 EDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:COG0642 303 ELHGGTIEVESEPGK-GTTFTVTLP 326
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
505-742 |
6.01e-47 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 167.01 E-value: 6.01e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 505 ELVSAQRKAAWADVARR-----IAHEIKNPLTPIQLSAERLRRkylkEISSDTEVFTMCTDTIVRQVDDIRRMVDEFSAF 579
Cdd:COG2205 1 ELEEALEELEELERLKSeflanVSHELRTPLTSILGAAELLLD----EEDLSPEERRELLEIIRESAERLLRLIEDLLDL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 580 ARM----PQPVMKPVNINDLVRQAV-FLQSSAHSGKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAiegrTPPAe 654
Cdd:COG2205 77 SRLesgkLSLELEPVDLAELLEEAVeELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKY----SPPG- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 655 ggelppGEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYV----TTRAKGTGLGLAIVKKIMEDHGGMLTLEDRE 730
Cdd:COG2205 152 ------GTITISARREGDGVRISVSDNGPGIPE-EELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEP 224
|
250
....*....|..
gi 933521231 731 GGtGARVTLVVP 742
Cdd:COG2205 225 GG-GTTFTVTLP 235
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
627-742 |
3.42e-44 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 154.62 E-value: 3.42e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 627 DSRQISQALTNLLQNAADAIEGRtppaeggELPPGEVSIAVEDD-GERVVVTVEDNGRGLPGgEQRDRLTEPYVTTRAKG 705
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGR-------PSDVGEVRIRVEADqDGRIVLIVCDNGKGFPR-EMRHRATEPYVTTRPKG 72
|
90 100 110
....*....|....*....|....*....|....*..
gi 933521231 706 TGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:cd16944 73 TGLGLAIVKKIMEEHGGRISLSNREAG-GACIRIILP 108
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
363-742 |
2.67e-43 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 161.64 E-value: 2.67e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 363 FVLLSRAFNRMTTEIEGQRRELLSTNRLLDERRRFTETVLSGVSAGVLGLDADGVINLPNLSAARLLDEEDPDRMVGMPL 442
Cdd:COG5002 15 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 443 VELLPDMGDLLENAPKRPGRVVQDQIQIRRPGKPTLTLLVRIAAEVRGGDVRGYVVTFDDITELVSAQRkaawadvARR- 521
Cdd:COG5002 95 LLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQ-------MRRe 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 522 ----IAHEIKNPLTPIQLSAERLRRkylkEISSDTEVFTMCTDTIVRQVDDIRRMVDEFSAFARM----PQPVMKPVNIN 593
Cdd:COG5002 168 fvanVSHELRTPLTSIRGYLELLLD----GAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLesgeLKLEKEPVDLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 594 DLVRQAV-FLQSSAHSGKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAiegrTPPAeggelppGEVSIAVEDDGE 672
Cdd:COG5002 244 ELLEEVVeELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKY----TPEG-------GTITVSLREEDD 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 933521231 673 RVVVTVEDNGRGLPGgEQRDRLTEPYVTTRA------KGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:COG5002 313 QVRISVRDTGIGIPE-EDLPRIFERFYRVDKsrsretGGTGLGLAIVKHIVEAHGGRIWVESEPGK-GTTFTITLP 386
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
390-739 |
5.43e-42 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 160.14 E-value: 5.43e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 390 LLDERRRFTeTVLSGVSAGVLGLDADGVINLPNLSAARLL--DEEDPDrmvGMPLVELLPdmGDLLENAPKRPGRVVQD- 466
Cdd:COG5809 136 LRESEEKFR-LIFNHSPDGIIVTDLDGRIIYANPAACKLLgiSIEELI---GKSILELIH--SDDQENVAAFISQLLKDg 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 467 ---QIQIRRPGK--PTLTLLVRIAAEVRGGDVRGYVVTFDDITELVSAQ---RKAAWADVARR----IAHEIKNPLTP-- 532
Cdd:COG5809 210 giaQGEVRFWTKdgRWRLLEASGAPIKKNGEVDGIVIIFRDITERKKLEellRKSEKLSVVGElaagIAHEIRNPLTSlk 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 533 --IQLsaerlrrkyLKEisSDTEVFTMCTDTIVRQVDDIRRMVDEFSAFARmPQPV-MKPVNINDLVRQAV-FLQSSAHS 608
Cdd:COG5809 290 gfIQL---------LKD--TIDEEQKTYLDIMLSELDRIESIISEFLVLAK-PQAIkYEPKDLNTLIEEVIpLLQPQALL 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 609 GKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAIegrtppAEGGELppgEVSIAVEDDGeRVVVTVEDNGRGLPGg 688
Cdd:COG5809 358 KNVQIELELEDDIPDILGDENQLKQVFINLLKNAIEAM------PEGGNI---TIETKAEDDD-KVVISVTDEGCGIPE- 426
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 933521231 689 EQRDRLTEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREG-GTGARVTL 739
Cdd:COG5809 427 ERLKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGkGTTFSITL 478
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
461-743 |
1.95e-40 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 152.63 E-value: 1.95e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 461 GRVVQDQIQIRRPGKPTLTLLVRIAAEVRGGDVRGYVVTFDDIT-------ELVSAQRKAAWADVARRIAHEIKNPLTPI 533
Cdd:COG5807 86 NKEAFDRIEISYLTKNGEFDEIIYPIYYKDGVILGLITVYRDITkrkeaedKLLRSEKLSVAGELAAGIAHEIRNPLTSI 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 534 ----QLSaerlrrKYLKEISSDTEVFTMctdtIVRQVDDIRRMVDEFSAFARMPQPVMKPVNINDLVRQAV-FLQSSAHS 608
Cdd:COG5807 166 kgflQLL------QESREDSEREEYFNI----IISEIDRINTIITELLVLSKPKKFNFKKLNLNDVLEDVIaLLSTEAIL 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 609 GKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAIEgrtppaEGGELppgevSIAVEDDGERVVVTVEDNGRGLPgG 688
Cdd:COG5807 236 KNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAME------TGGNI-----TIKTYVEGDFVVISVKDEGIGIP-E 303
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 933521231 689 EQRDRLTEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVPH 743
Cdd:COG5807 304 EVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESKPGK-GTTFTIYLPL 357
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
509-742 |
2.53e-39 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 151.83 E-value: 2.53e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 509 AQRKAAWADVARRIAHEIKNPLTPIQLSAERLRRKYLKEIssDTEVFtmctDTIVRQVDDIRRMVDEFSAFARMPQPVMK 588
Cdd:COG5808 235 TQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELE--DQKYF----DIIQEEIQRINQIVSEFLVLGKPTAKKLE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 589 PVNINDLVRQAV-FLQSSAHSGKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAIEgrtppaEGGELppgevSIAV 667
Cdd:COG5808 309 LDDLNELIEEILsIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMK------EGGKL-----TISI 377
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 933521231 668 EDDGERVVVTVEDNGRGLPGGEQrDRLTEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREgGTGARVTLVVP 742
Cdd:COG5808 378 ENDDEKAVIEVIDNGEGIPEDII-DEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEE-GKGTTFTIRLP 450
|
|
| NtrY_N |
pfam19312 |
NtrY N-terminal region; This entry represents the probable sensor region of the two component ... |
81-305 |
4.12e-37 |
|
NtrY N-terminal region; This entry represents the probable sensor region of the two component regulator protein NtrY. This region includes four probable transmembrane helices.
Pssm-ID: 437144 Cd Length: 291 Bit Score: 140.76 E-value: 4.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 81 VLIARRIvAILIGRRRGLAGS-RLHTRLVLVFSLLAVAPAIIMTVFSTLFFYVGVQSWFSERVRTAVNESLVVASAYLHE 159
Cdd:pfam19312 54 VLLGRRI-ALRRAARSPIGGTgRLHVRLVALFSLIAAVPTLLVVIFASLLFQYGVEFWFSDRARGMLENANELAQGYYEE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 160 HQQNIRADALAMANDLSQE-ARFSSDPERFEQVVATQAMLRTLSEAIVF----NGT--TGAIVARAGYTFTLEfepIPEE 232
Cdd:pfam19312 133 NQRRVGDETVAMAGDLRGYlRQAPIDSPRFAEFYAYQVYYRNLSESAILqrgpDGElrTAAIVNPDERDLPRR---ITPA 209
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 933521231 233 KVQQARNGEvALIVKETDDRVRALVSLDRVSDTFLYVGRMVEPRVLQHMASAEGAVKEYTALENQRGSLQVTF 305
Cdd:pfam19312 210 VLARLRAGE-PVVVTASGDRIEAVTPLDRESGIYLYAARVSDPLALSQWERAQSVLADYRALTSRARALQLRF 281
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
363-742 |
1.85e-34 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 136.13 E-value: 1.85e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 363 FVLLSRAFNRMTTEIEGQRRELLstnRLLDERrrftETVLSGVSAGVLGLDADGVINLPNLSAARLLDEEdpdrMVGMPL 442
Cdd:COG3290 58 LILLLLLLLLLAALLLKLLEEIA---RLVEER----EAVLESIREGVIAVDRDGRITLINDAARRLLGLD----AIGRPI 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 443 VELLPDmgdllenapkrpgrVVQDQIQIRRPGKPTLTLLVRIAAEVRGGDVRGYVVTFDDITELVSAQRKAAW----ADV 518
Cdd:COG3290 127 DEVLAE--------------VLETGERDEEILLNGRVLVVNRVPIRDDGRVVGAVATFRDRTELERLEEELEGvkelAEA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 519 ARRIAHEIKNPLTPI----QLSAERLRRKYLKEISSDTEVFTmctDTIVRQVDDirrmvdefsafarmpqpvmkpVNIND 594
Cdd:COG3290 193 LRAQRHDFRNHLHTIsgllQLGEYDEALEYIDEISEELQELI---DSLLSRIGN---------------------PVLAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 595 LVRQAVflqSSAHSGKIRF----ETRLPQGPLtvacDSRQISQALTNLLQNAADAiegrtppAEGGELPPGEVSIAVEDD 670
Cdd:COG3290 249 LLLGKA---ARARERGIDLtidiDSDLPDLPL----SDTDLVTILGNLLDNAIEA-------VEKLPEEERRVELSIRDD 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 933521231 671 GERVVVTVEDNGRGLPGgEQRDRLTEPYVTTRAK-GTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:COG3290 315 GDELVIEVEDSGPGIPE-ELLEKIFERGFSTKLGeGRGLGLALVKQIVEKYGGTIEVESEEGE-GTVFTVRLP 385
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
413-742 |
2.07e-34 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 137.94 E-value: 2.07e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 413 DADGVINLPNLSAARLLDEEdPDRMVGMPLVELLPDMgDLLEnapkrpgrvVQDQIQIRRPGKPTLTLLVRIAA------ 486
Cdd:COG5805 174 DTDGRILFINESIERLFGAP-REELIGKNLLELLHPC-DKEE---------FKERIESITEVWQEFIIEREIITkdgrir 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 487 --EVRG-------GDVRGYVVTFDDITELVSAQRKAAWAD-------VARRIAHEIKNPLTPI-------QLSAERlRRK 543
Cdd:COG5805 243 yfEAVIvplidtdGSVKGILVILRDITEKKEAEELMARSEklsiagqLAAGIAHEIRNPLTSIkgflqllQPGIED-KEE 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 544 YLkeissdtevftmctDTIVRQVDDIRRMVDEFSAFARMPQPVMKPVNINDLVRQAV-FLQSSA--HSGKIRFETRLPQg 620
Cdd:COG5805 322 YF--------------DIMLSELDRIESIISEFLALAKPQAVNKEKENINELIQDVVtLLETEAilHNIQIRLELLDED- 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 621 pLTVACDSRQISQALTNLLQNAADAIEGrtppaeggelpPGEVSIAVEDDGERVVVTVEDNGRGLPggEQR-DRLTEPYV 699
Cdd:COG5805 387 -PFIYCDENQIKQVFINLIKNAIEAMPN-----------GGTITIHTEEEDNSVIIRVIDEGIGIP--EERlKKLGEPFF 452
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 933521231 700 TTRAKGTGLGLAIVKKIMEDHGGMLTLeDREGGTGARVTLVVP 742
Cdd:COG5805 453 TTKEKGTGLGLMVSYKIIENHNGTIDI-DSKVGKGTTFTITLP 494
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
523-742 |
1.29e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 120.33 E-value: 1.29e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 523 AHEIKNPLTPIQLSAERLRRkylkeiSSDTEVFTMCTDTIVRQVDDIRRMVDEFSAFARMPQP----VMKPVNINDLVRQ 598
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQE------DPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRqeleVLEPVALAALLEE 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 599 AV-FLQSSAHSGKIRFETRLPqgPLTVACDSRQISQALTNLLQNAADAiegrTPPAeggelppGEVSIAVEDDGERVVVT 677
Cdd:PRK11100 338 LVeAREAQAAAKGITLRLRPD--DARVLGDPFLLRQALGNLLDNAIDF----SPEG-------GTITLSAEVDGEQVALS 404
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 678 VEDNGRGLPGGEQrDRLTE-----PYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:PRK11100 405 VEDQGPGIPDYAL-PRIFErfyslPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEG-GVLATLTLP 472
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
253-742 |
2.70e-27 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 116.81 E-value: 2.70e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 253 VRALVSLDRVSDTFLYVGRMVEPRVLQHMASAEGAVKEYTALENQRGSLQVTFTLIFLVVAMLLLLAAVWAGLNFATRLV 332
Cdd:COG4251 1 LLLLALLLLLLLLLLLLLLLLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 333 RPISALIGAAERVRAGDLTVRVSEPPGEDEFVLLSRAFNRMTTEIEGQRRELLSTNRLLDERRRFTETVLSGVSAGVLGL 412
Cdd:COG4251 81 LLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 413 DADGVINLPNLSAARLLDEEDPDRMVGMPLVELLPDMGDLLENAPKRPGRVVQDQIQIRRPGKPTLTLLVRIAAEVRGGD 492
Cdd:COG4251 161 LLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 493 VRGYVVTFDDITELVSAQ--RKAAWADVARRIA-----------------HEIKNPLTPIQLSAERLRRKYLKEISSDTE 553
Cdd:COG4251 241 LILLLLLLILVLELLELRleLEELEEELEERTAelersneeleqfayvasHDLREPLRKISGFSQLLEEDYGDKLDEEGR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 554 VFTmctDTIVRQVDDIRRMVDEFSAFARM--PQPVMKPVNINDLVRQAV-FLQSSAHSGKIRFETrlpqGPL-TVACDSR 629
Cdd:COG4251 321 EYL---ERIRDAAERMQALIDDLLAYSRVgrQELEFEPVDLNELLEEVLeDLEPRIEERGAEIEV----GPLpTVRGDPT 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 630 QISQALTNLLQNAADAIEGRTPPaeggelppgEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVTTRAK----G 705
Cdd:COG4251 394 LLRQVFQNLISNAIKYSRPGEPP---------RIEIGAEREGGEWVFSVRDNGIGIDP-EYAEKIFEIFQRLHSRdeyeG 463
|
490 500 510
....*....|....*....|....*....|....*..
gi 933521231 706 TGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:COG4251 464 TGIGLAIVKKIVERHGGRIWVESEPGE-GATFYFTLP 499
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
505-742 |
1.16e-26 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 113.42 E-value: 1.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 505 ELVSAQRKAAWADVARRIAHEIKNPLTP----IQL------SAERlRRKYLKeissdtevftmctdTIVRQVDDIRRMVD 574
Cdd:COG5806 191 ELQRAEKLEVVSELAASIAHEVRNPLTVvrgfIQLlqepelSDEK-RKQYIR--------------IALEELDRAEAIIT 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 575 EFSAFARmPQP-VMKPVNINDLVRQAV-FLQSSAHSGKIRFETRLPqGPLTVACDSRQISQALTNLLQNAADAIEGrtpp 652
Cdd:COG5806 256 DYLTFAK-PQPeKLEKIDVSEELEHVIdVLSPYANMNNVEIQTELE-PGLYIEGDRQKLQQCLINIIKNGIEAMPN---- 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 653 aeGGELppgevSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDrEGG 732
Cdd:COG5806 330 --GGTL-----TIDVSIDKNKVIISIKDTGVGMTK-EQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVES-EVG 400
|
250
....*....|
gi 933521231 733 TGARVTLVVP 742
Cdd:COG5806 401 KGTTFTITLP 410
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
522-739 |
1.52e-26 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 113.47 E-value: 1.52e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 522 IAHEIKNPLTPIQLSAERLRRK--YLKE-ISSDTEvftmctdtivrQVDDIrrmVDEFSAFARMPQ-PVMKPVNINDLVR 597
Cdd:PRK09467 236 VSHDLRTPLTRIRLATEMMSEEdgYLAEsINKDIE-----------ECNAI---IEQFIDYLRTGQeMPMEMADLNALLG 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 598 QAVflqsSAHSGKIR-FETRLPQGPLTVACDSRQISQALTNLLQNAAdaiegRTppaeGGelppGEVSIAVEDDGERVVV 676
Cdd:PRK09467 302 EVI----AAESGYEReIETALQPGPIEVPMNPIAIKRALANLVVNAA-----RY----GN----GWIKVSSGTEGKRAWF 364
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 933521231 677 TVEDNGRGLPGgEQRDRLTEPYV---TTR-AKGTGLGLAIVKKIMEDHGGMLTLEDR-EGGTGARVTL 739
Cdd:PRK09467 365 QVEDDGPGIPP-EQLKHLFQPFTrgdSARgSSGTGLGLAIVKRIVDQHNGKVELGNSeEGGLSARAWL 431
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
505-742 |
3.75e-26 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 112.57 E-value: 3.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 505 ELVSAQRKAAWADVARRIAHEIKNPLTPIQLSAERLRRKYlKEISSDTEVftmcTDTIVRQVDDIRRMVDEFSAFARMPQ 584
Cdd:PRK10364 227 EMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERA-PAGGEAHQL----AQVMAKEADRLNRVVSELLELVKPTH 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 585 PVMKPVNINDLVRQAVFLQSS-AHSGKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAIegrtppAEGGELppgev 663
Cdd:PRK10364 302 LALQAVDLNDLINHSLQLVSQdANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAI------GQHGVI----- 370
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 933521231 664 SIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREgGTGARVTLVVP 742
Cdd:PRK10364 371 SVTASESGAGVKISVTDSGKGIAA-DQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQE-GKGATFTLWLP 447
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
627-742 |
5.30e-26 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 103.11 E-value: 5.30e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 627 DSRQISQALTNLLQNAADAIEgrtppaeggelPPGEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVTTRA--- 703
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTP-----------EGGRITVTLERDGDHVEITVEDNGPGIPP-EDLEKIFEPFFRTDKrsr 69
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 933521231 704 --KGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:smart00387 70 kiGGTGLGLSIVKKLVELHGGEISVESEPGG-GTTFTITLP 109
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
631-739 |
1.80e-24 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 98.44 E-value: 1.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 631 ISQALTNLLQNAADAiegrTPPaeggelpPGEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVTTR----AKGT 706
Cdd:cd00075 1 LEQVLSNLLDNALKY----SPP-------GGTIEISLRQEGDGVVLEVEDNGPGIPE-EDLERIFERFYRGDksreGGGT 68
|
90 100 110
....*....|....*....|....*....|....
gi 933521231 707 GLGLAIVKKIMEDHGGMLTLEDREG-GTGARVTL 739
Cdd:cd00075 69 GLGLAIVRRIVEAHGGRITVESEPGgGTTFTVTL 102
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
509-722 |
1.63e-23 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 106.69 E-value: 1.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 509 AQRKAAWADVARRIAHEIKNPLTPIQLSAE---------RLRRKYLKEISSDTevftmctdtivrqvDDIRRMVDEFSAF 579
Cdd:PRK13837 444 ARRLEAVGTLASGIAHNFNNILGAILGYAEmalnklarhSRAARYIDEIISAG--------------ARARLIIDQILAF 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 580 ARMPQPVMKPVNINDLVRQAVFLQSSAHSGKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAIEGR---TPPAEGG 656
Cdd:PRK13837 510 GRKGERNTKPFDLSELVTEIAPLLRVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAgrvDISLSRA 589
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 933521231 657 ELP-PGEVSIAVEDDGERVVVTVEDNGRGLPGGeQRDRLTEPYVTTRAKGTGLGLAIVKKIMEDHGG 722
Cdd:PRK13837 590 KLRaPKVLSHGVLPPGRYVLLRVSDTGAGIDEA-VLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAG 655
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
627-742 |
1.44e-21 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 90.12 E-value: 1.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 627 DSRQISQALTNLLQNAADAiegrtppaeggELPPGEVSIAVEDDGeRVVVTVEDNGRGLPGgEQRDRLTEPYVT---TRA 703
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKH-----------AAKAGEITVTLSEGG-ELTLTVEDNGIGIPP-EDLPRIFEPFSTadkRGG 68
|
90 100 110
....*....|....*....|....*....|....*....
gi 933521231 704 KGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:pfam02518 69 GGTGLGLSIVRKLVELLGGTITVESEPGG-GTTVTLTLP 106
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
630-743 |
1.45e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 90.17 E-value: 1.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 630 QISQALTNLLQNAADAIEGRtppaeggelppGEVSIAVEDDGERVVVTVEDNGRGLPgGEQRDRLTEPYVTTR--AKGTG 707
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGR-----------GRITIRTWAHVDQVLIEVEDTGSGID-PEILGRIFDPFFTTKpvGEGTG 70
|
90 100 110
....*....|....*....|....*....|....*.
gi 933521231 708 LGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVPH 743
Cdd:cd16943 71 LGLSLSYRIIQKHGGTIRVASVPGG-GTRFTIILPI 105
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
631-739 |
5.59e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 82.50 E-value: 5.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 631 ISQALTNLLQNAADAIEGRTPPAeggelppgeVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVTTR--AKGTGL 708
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENPR---------IRIAARRLGGRLVLVVRDNGPGIAE-EHLSRVFDPFFTTKpvGKGTGL 70
|
90 100 110
....*....|....*....|....*....|.
gi 933521231 709 GLAIVKKIMEDHGGMLTLEDREGGtGARVTL 739
Cdd:cd16976 71 GLSISYGIVEEHGGRLSVANEEGA-GARFTF 100
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
631-739 |
1.08e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 78.98 E-value: 1.08e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 631 ISQALTNLLQNAADAIEGRTPpaEGGELppgEVSIAVEDDGErVVVTVEDNGRGLPGgEQRDRLTEPYVTTRAKGTGLGL 710
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGC--ERREL---TIRTSPADDRA-VTISVKDTGPGIAE-EVAGQLFDPFYTTKSEGLGMGL 73
|
90 100 110
....*....|....*....|....*....|
gi 933521231 711 AIVKKIMEDHGGMLTLEDR-EGGTGARVTL 739
Cdd:cd16920 74 SICRSIIEAHGGRLSVESPaGGGATFQFTL 103
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
505-726 |
4.00e-17 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 85.51 E-value: 4.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 505 ELVSAQRKAAWADVARRIAHEIKNPLTPIQLSAERLRRKYLKEissDTEVFTMCTDTIVRQVDDIRRMVDEFSAFARMPQ 584
Cdd:COG4192 423 ELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKKALEQE---NYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSD 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 585 PVMKPVNINDLVRQAVFLQSSAHsgKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAIEGrtppaeggelpPGEVS 664
Cdd:COG4192 500 TPLQPVDLRQVIEQAWELVESRA--KPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVAT-----------QPQIS 566
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 933521231 665 IAVEDDGERVVVTVEDNGRGLPggeQRDRLTEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTL 726
Cdd:COG4192 567 VDLLSNAENLRVAISDNGNGWP---LVDKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYL 625
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
509-733 |
1.61e-16 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 81.67 E-value: 1.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 509 AQRKAAwADVARRIAHEIKNPLTPIQlSAERLRRKYLKEISsdtevFTMCTDTIVRQVDDIRRMVDEFSAfarmPQ-PVM 587
Cdd:PRK11073 125 AQQVAA-RDLVRGLAHEIKNPLGGLR-GAAQLLSKALPDPA-----LTEYTKVIIEQADRLRNLVDRLLG----PQrPGT 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 588 K-PVNINDL---VRQAVFLQSSAHSGKIR-FETRLPQgpltVACDSRQISQALTNLLQNAADAIegrtppAEGGelppGE 662
Cdd:PRK11073 194 HvTESIHKVaerVVQLVSLELPDNVRLIRdYDPSLPE----LAHDPDQIEQVLLNIVRNALQAL------GPEG----GT 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 663 VSIAVEDD------GER----VVVTVEDNGRGLPGgEQRDRLTEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGG 732
Cdd:PRK11073 260 ITLRTRTAfqltlhGERyrlaARIDIEDNGPGIPP-HLQDTLFYPMVSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGH 338
|
.
gi 933521231 733 T 733
Cdd:PRK11073 339 T 339
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
506-769 |
1.93e-16 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 83.18 E-value: 1.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 506 LVSAQRKAAWADVARRIAHEIKNPLTPIQlsaerlrrKYLKEISSDTEVFTMCTDTIVRQVDDIRRMVDEFS-------A 578
Cdd:PRK13557 154 LRQAQKMEALGQLTGGIAHDFNNLLQVMS--------GYLDVIQAALSHPDADRGRMARSVENIRAAAERAAtltqqllA 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 579 FARMPQPVMKPVNINDLVRQAVFLQSSAHSGKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAIEGR---TPPAEG 655
Cdd:PRK13557 226 FARKQRLEGRVLNLNGLVSGMGELAERTLGDAVTIETDLAPDLWNCRIDPTQAEVALLNVLINARDAMPEGgrvTIRTRN 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 656 GEL-PPGEVSIAVEDDGERVVVTVEDNGRGLPgGEQRDRLTEPYVTTR--AKGTGLGLAIVKKIMEDHGGMLTLEDREGG 732
Cdd:PRK13557 306 VEIeDEDLAMYHGLPPGRYVSIAVTDTGSGMP-PEILARVMDPFFTTKeeGKGTGLGLSMVYGFAKQSGGAVRIYSEVGE 384
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 933521231 733 tGARVTLVVP------HPVAAVADVKADAGGR------DDRP--AETGGEM 769
Cdd:PRK13557 385 -GTTVRLYFPasdqaeNPEQEPKARAIDRGGTetilivDDRPdvAELARMI 434
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
631-739 |
1.97e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 75.51 E-value: 1.97e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 631 ISQALTNLLQNAADAIEGRtppaeGGE-LPPGEVSIAVEDDGER----VVVTVEDNGRGLPGgEQRDRLTEPYVTTRAKG 705
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGS-----GGEiILRTRTQRQVTLGHPRhrlaLRVSVIDNGPGIPP-DLQDTIFYPMVSGRENG 74
|
90 100 110
....*....|....*....|....*....|....
gi 933521231 706 TGLGLAIVKKIMEDHGGMLTLEDREGGTGARVTL 739
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSL 108
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
631-739 |
2.63e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 75.18 E-value: 2.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 631 ISQALTNLLQNAADaiegrtppaEGGelppGEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVTTRA----KGT 706
Cdd:cd16950 1 LKRVLSNLVDNALR---------YGG----GWVEVSSDGEGNRTRIQVLDNGPGIAP-EEVDELFQPFYRGDNargtSGT 66
|
90 100 110
....*....|....*....|....*....|....
gi 933521231 707 GLGLAIVKKIMEDHGGMLTLEDRE-GGTGARVTL 739
Cdd:cd16950 67 GLGLAIVQRISDAHGGSLTLANRAgGGLCARIEL 100
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
498-742 |
2.83e-15 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 78.88 E-value: 2.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 498 VTF----DDITELVsAQRKAawadVARRIAHEIKNPLTpiqlsaeRLR-RKYLKEISSDTEvftmcTDTIVRQVDDIRRM 572
Cdd:PRK10604 196 VAFnqmaDNINALI-ASKKQ----LIDGIAHELRTPLV-------RLRyRLEMSDNLSAAE-----SQALNRDIGQLEAL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 573 VDEFSAFARM--PQPVMKPVNInDLvrqAVFLQSSAH-----SGKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADA 645
Cdd:PRK10604 259 IEELLTYARLdrPQNELHLSEP-DL---PAWLSTHLAdiqavTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRY 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 646 IEGRtppaeggelppgeVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYV------TTRAKGTGLGLAIVKKIMED 719
Cdd:PRK10604 335 AHSR-------------VRVSLLLDGNQACLIVEDDGPGIPP-EERERVFEPFVrldpsrDRATGGCGLGLAIVHSIALA 400
|
250 260
....*....|....*....|...
gi 933521231 720 HGGMLTLEDREGGtGARVTLVVP 742
Cdd:PRK10604 401 MGGSVNCDESELG-GARFSFSWP 422
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
633-739 |
1.29e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 70.18 E-value: 1.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 633 QALTNLLQNAADAiegrTPPAeggelppGEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVT-----TRAKGTG 707
Cdd:cd16945 7 QAINNLLDNAIDF----SPEG-------GLIALQLEADTEGIELLVFDEGSGIPD-YALNRVFERFYSlprphSGQKSTG 74
|
90 100 110
....*....|....*....|....*....|..
gi 933521231 708 LGLAIVKKIMEDHGGMLTLEDREGGTGARVTL 739
Cdd:cd16945 75 LGLAFVQEVAQLHGGRITLRNRPDGVLAFLTL 106
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
629-742 |
1.57e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 70.21 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 629 RQIsqaLTNLLQNAadaiegrtppaeggeL---PPGEVSIAV-----EDDGERVVVTVEDNGRGLPGgEQRDRLTEPYV- 699
Cdd:cd16922 2 RQI---LLNLLGNA---------------IkftEEGEVTLRVsleeeEEDGVQLRFSVEDTGIGIPE-EQQARLFEPFSq 62
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 933521231 700 -----TTRAKGTGLGLAIVKKIMEDHGGMLTLEdREGGTGARVTLVVP 742
Cdd:cd16922 63 adsstTRKYGGTGLGLAISKKLVELMGGDISVE-SEPGQGSTFTFTLP 109
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
637-742 |
1.27e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 67.31 E-value: 1.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 637 NLLQNAADAiegrtppAEGGELPPGEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVTTRA-KGTGLGLAIVKK 715
Cdd:cd16915 7 NLIDNALDA-------LAATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAP-ELRDKVFERGVSTKGqGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*..
gi 933521231 716 IMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:cd16915 79 SVERLGGSITVESEPGG-GTTFSIRIP 104
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
633-739 |
1.65e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 67.40 E-value: 1.65e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 633 QALTNLLQNAADAIegrtppAEGGELPPGEVSIAVEDD----------GERVVVTVEDNGRGLPGgEQRDRLTEPYVTTR 702
Cdd:cd16919 3 LAILNLAVNARDAM------PEGGRLTIETSNQRVDADyalnyrdlipGNYVCLEVSDTGSGMPA-EVLRRAFEPFFTTK 75
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 933521231 703 --AKGTGLGLAIVKKIMEDHGGMLTLEDREG-GTGARVTL 739
Cdd:cd16919 76 evGKGTGLGLSMVYGFVKQSGGHLRIYSEPGvGTTVRIYL 115
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
631-742 |
4.17e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 63.11 E-value: 4.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 631 ISQALTNLLQNAAdaiegrtppaeggELPPGEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPY-----VTTRAK- 704
Cdd:cd16949 1 LARALENVLRNAL-------------RYSPSKILLDISQDGDQWTITITDDGPGVPE-DQLEQIFLPFyrvdsARDRESg 66
|
90 100 110
....*....|....*....|....*....|....*...
gi 933521231 705 GTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:cd16949 67 GTGLGLAIAERAIEQHGGKIKASNRKPG-GLRVRIWLP 103
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
631-742 |
4.81e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 62.83 E-value: 4.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 631 ISQALTNLLQNAADAIEGRtppaeggelppgeVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYV-----TTRAK- 704
Cdd:cd16939 1 MARALDNLLRNALRYAHRT-------------VRIALLVSGGRLTLIVEDDGPGIPA-AARERVFEPFVrldpsRDRATg 66
|
90 100 110
....*....|....*....|....*....|....*...
gi 933521231 705 GTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:cd16939 67 GFGLGLAIVHRVALWHGGHVECDDSELG-GACFRLTWP 103
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
631-742 |
6.20e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 62.73 E-value: 6.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 631 ISQALTNLLQNAadaIEGRTPPaeggelPPGEVSIAVEDDGERVVVTVEDNGRGLP--------GGEQRDRLTEPYvttr 702
Cdd:cd16921 1 LGQVLTNLLGNA---IKFRRPR------RPPRIEVGAEDVGEEWTFYVRDNGIGIDpeyaekvfGIFQRLHSREEY---- 67
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 933521231 703 aKGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:cd16921 68 -EGTGVGLAIVRKIIERHGGRIWLESEPGE-GTTFYFTLP 105
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
619-739 |
6.31e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 62.81 E-value: 6.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 619 QGPLTVACDSRQISQALTNLLQNAAdaiegRTPPAEGgelppgEVSIAVEDDgERVVVTVEDNGRGLPGgEQRDRLTEPY 698
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAV-----RYSPQGS------RVEIKLSAD-DGAVIRVEDNGPGIDE-EELEALFERF 68
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 933521231 699 V---TTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTL 739
Cdd:cd16940 69 YrsdGQNYGGSGLGLSIVKRIVELHGGQIFLGNAQGG-GLEAWV 111
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
389-742 |
7.19e-12 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 68.79 E-value: 7.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 389 RLLDERrrftETVLSGVSAGVLGLDADGVINLPNLSAARLL------DEEDPDRMV--GMPLVELlpdmGDLLENapkrp 460
Cdd:PRK11086 218 TLFEQR----QAMLQSIKEGVIAVDDRGEVTLINDEAKRLFnykkglEDDPLGTDVesWMPVSRL----KEVLRT----- 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 461 GRVVQDQiQIRRPGkptLTLLVRIAAEVRGGDVRGYVVTFDDITElVS--AQR---KAAWADVARRIAHEIKNPLTPI-- 533
Cdd:PRK11086 285 GTPRRDE-EINING---RLLLTNTVPVRVNGEIIGAIATFRDKTE-VRqlAQRldgMVNYADALRAQSHEFMNKLHVIlg 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 534 --QL-SAERLRrKYLKEISSD--TEvftmcTDTIVRQVDDirrmvdefsafarmpqPVMkpvnindlvrqAVFLQS---- 604
Cdd:PRK11086 360 llHLkSYDQLE-DYILKTANNyqEE-----IGSLLGKIKS----------------PVI-----------AGFLLGkisr 406
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 605 ---SAHSGKIRFETRLPQGPltvacDSRQISQALT---NLLQNAADAIegrtppaegGELPPGEVSIAVEDDGERVVVTV 678
Cdd:PRK11086 407 areLGITLIISEDSQLPDSG-----DEDQVHELITilgNLIENALEAV---------GGEEGGEISVSLHYRNGWLHCEV 472
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 933521231 679 EDNGRGLPGGEQRDRLTEPYvTTRAKGTGLGLAIVKKIMEDHGGMLTLEDrEGGTGARVTLVVP 742
Cdd:PRK11086 473 SDDGPGIAPDEIDAIFDKGY-STKGSNRGVGLYLVKQSVENLGGSIAVES-EPGVGTQFFVQIP 534
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
518-722 |
1.34e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 66.90 E-value: 1.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 518 VARRIAHEIKNPLTPIQLSAERLRRKYLKEIS-SDTEVFTMCTDTIVRQVDDIRRMVDEF--------SAFARMPQPVmk 588
Cdd:PRK09303 154 VLAMLAHDLRTPLTAASLALETLELGQIDEDTeLKPALIEQLQDQARRQLEEIERLITDLlevgrtrwEALRFNPQKL-- 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 589 pvninDL--VRQAVFLQSSAH--SGKIRFETRLPQGPLTVACDSRQISQALTNLLQNAADAiegrTPpaEGGElppgeVS 664
Cdd:PRK09303 232 -----DLgsLCQEVILELEKRwlAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKY----TP--EGGT-----IT 295
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 665 IAVED-DGERVVVTVEDNGRGLPGGEQ-----------RDRLTEPYvttrakgtGLGLAIVKKIMEDHGG 722
Cdd:PRK09303 296 LSMLHrTTQKVQVSICDTGPGIPEEEQerifedrvrlpRDEGTEGY--------GIGLSVCRRIVRVHYG 357
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
516-744 |
1.83e-11 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 66.53 E-value: 1.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 516 ADVArriaHEIKNPLTPIQLSAErlrrkyLKEISSDTEVftmctDTIVRQVDDIRRMVDEFSAFARMPQPVM----KPVN 591
Cdd:PRK10755 142 ADVA----HELRTPLAGIRLHLE------LLEKQHHIDV-----APLIARLDQMMHTVEQLLQLARAGQSFSsghyQTVK 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 592 INDLVRQAVFLQSSAHSGKIRFETRLPQGP--LTVACDSRQISQALTNLLQNAAdaiegRTPPaEGGELppgEVSIAVED 669
Cdd:PRK10755 207 LLEDVILPSQDELSEMLEQRQQTLLLPESAadITVQGDATLLRLLLRNLVENAH-----RYSP-EGSTI---TIKLSQED 277
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 933521231 670 DGerVVVTVEDNGRGLPGgEQRDRLTEPYV--TTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGTGARVTLVVPHP 744
Cdd:PRK10755 278 GG--AVLAVEDEGPGIDE-SKCGELSKAFVrmDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERSGTRAWVWLPKA 351
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
522-742 |
2.18e-11 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 66.64 E-value: 2.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 522 IAHEIKNPL------TPIQLSAERLRRKYLKEISSDTEvftmctdtivrQVDDIRRMVDEFSAFARMPQPVMKP----VN 591
Cdd:TIGR01386 248 LAHELRTPLtnllgqTQVALSQPRTGEEYREVLESNLE-----------ELERLSRMVSDMLFLARADNGQLALervrLD 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 592 IN-DLVRQAVFLQSSAHSGKIRFETRlpqGPLTVACDSRQISQALTNLLQNAADaiegRTPPAeggelppGEVSIAVEDD 670
Cdd:TIGR01386 317 LAaELAKVAEYFEPLAEERGVRIRVE---GEGLVRGDPQMFRRAISNLLSNALR----HTPDG-------GTITVRIERR 382
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 933521231 671 GERVVVTVEDNGRGLPGgEQRDRLTE------PYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGTgaRVTLVVP 742
Cdd:TIGR01386 383 SDEVRVSVSNPGPGIPP-EHLSRLFDrfyrvdPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKT--RFILRFP 457
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
236-742 |
6.69e-11 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 65.31 E-value: 6.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 236 QARNGEVALIVKETDDRVRALVSLDRVSDTFLYVGRMVEPRVLQHMASAEGAVKEYTALENQRGSLQVTFTLIFLVVAML 315
Cdd:COG3920 10 LLALAALLLLAALLLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 316 LLLAAVWAGLNFATRLVRPISALIGAAERVRAGDLTVRVSEPPGEDEFVLLSRAFNRMTTEIEGQRRELLSTNRLLDERR 395
Cdd:COG3920 90 LLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 396 RFTETVLSGVSAGVLGLDADGVINLPNLSAARLLDEEDPDRMVGMPLVELLPDMGDLLENAPKRPGRVVQDQIQIRRPGK 475
Cdd:COG3920 170 LRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 476 PTLTLLVRIAAEVRGGDVRGYVVTFDDITELVSAQRKAAWADVARR------IAHEIKNPLTPIQ----LSAERLRRKYL 545
Cdd:COG3920 250 LGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKelllreLHHRVKNNLQVVSsllrLQARRADDPEA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 546 KEISSDTEvftmctdtivrqvddiRRMvdefSAFAR-----MPQPVMKPVNINDLVRQAV-FLQSSAHSGKIRFETRLPQ 619
Cdd:COG3920 330 REALEESQ----------------NRI----QALALvhellYQSEDWEGVDLRDYLRELLePLRDSYGGRGIRIELDGPD 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 620 GPLtvacDSRQ---ISQALTNLLQNAAD--AIEGRTppaeggelppGEVSIAVEDDGERVVVTVEDNGRGLPGGeqrdrl 694
Cdd:COG3920 390 VEL----PADAavpLGLILNELVTNALKhaFLSGEG----------GRIRVSWRREDGRLRLTVSDNGVGLPED------ 449
|
490 500 510 520
....*....|....*....|....*....|....*....|....*...
gi 933521231 695 tepyvTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREggtGARVTLVVP 742
Cdd:COG3920 450 -----VDPPARKGLGLRLIRALVRQLGGTLELDRPE---GTRVRITFP 489
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
614-744 |
1.07e-10 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 65.44 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 614 ETRLPQGPLTVACDSRQISQALTNLLQNAADAIEGRTPpaeggelppgeVSIAVEDDGERVVVTVEDNGRGLPGGEQR-- 691
Cdd:PRK10490 762 NLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAE-----------IGIDAHVEGERLQLDVWDNGPGIPPGQEQli 830
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 933521231 692 -DRLTEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDR-EGGTGARVTLVVPHP 744
Cdd:PRK10490 831 fDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRpEGGACFRVTLPLETP 885
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
633-742 |
1.49e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 58.74 E-value: 1.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 633 QALTNLLQNAADAiegrTPPAEGgelppgEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYVTTRAKG------T 706
Cdd:cd16953 3 QVLRNLIGNAISF----SPPDTG------RITVSAMPTGKMVTISVEDEGPGIPQ-EKLESIFDRFYTERPANeafgqhS 71
|
90 100 110
....*....|....*....|....*....|....*....
gi 933521231 707 GLGLAIVKKIMEDHGGMLTLEDRE---GGTGARVTLVVP 742
Cdd:cd16953 72 GLGLSISRQIIEAHGGISVAENHNqpgQVIGARFTVQLP 110
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
627-742 |
1.50e-10 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 59.04 E-value: 1.50e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 627 DSRQISQALTNLLQNAADAiegrTPPAeggelppGEVSIAVE-DDGERVVVTVEDNGRGLPGgEQRDRLTEPY-----VT 700
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKF----TPDG-------GRIRCILEkFRLNRFLLTVSDSGPGIPP-NLREEIFERFrqgdgSS 68
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 933521231 701 TRAK-GTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:cd16925 69 TRAHgGTGLGLSIVKEFVELHGGTVTVSDAPGG-GALFQVELP 110
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
602-742 |
1.71e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 64.66 E-value: 1.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 602 LQSSAHSGKIRFETRL-PQGPLTVACDSRQISQALTNLLQNAADAIEGrtppaeggelppGEVSIAVEDDGERVVVTVED 680
Cdd:PRK15347 484 IQGPAQSKSLTLRTFVgAHVPLYLHLDSLRLRQILVNLLGNAVKFTET------------GGIRLRVKRHEQQLCFTVED 551
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 933521231 681 NGRGLPGGEQRDrLTEPY--VTTRAKGTGLGLAIVKKIMEDHGGMLTLeDREGGTGARVTLVVP 742
Cdd:PRK15347 552 TGCGIDIQQQQQ-IFTPFyqADTHSQGTGLGLTIASSLAKMMGGELTL-FSTPGVGSCFSLVLP 613
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
522-742 |
1.93e-10 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 63.80 E-value: 1.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 522 IAHEIKNPLTPIQLSAERLRRKY-----LKEIssDTEVF---TMCTDTIV---RQVDdirrmvdefSAFARMPQPVMKpv 590
Cdd:PRK09470 250 ISHELRTPLTRLQLATALLRRRQgeskeLERI--ETEAQrldSMINDLLVlsrNQQK---------NHLERETFKANS-- 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 591 nI-NDLVRQAVFlqSSAHSGKiRFETRLPQGPLTVACDSRQISQALTNLLQNA----ADAIEgrtppaeggelppgeVSI 665
Cdd:PRK09470 317 -LwSEVLEDAKF--EAEQMGK-SLTVSAPPGPWPINGNPNALASALENIVRNAlrysHTKIE---------------VAF 377
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 666 AVEDDGerVVVTVEDNGRGLPGgEQRDRLTEPYV---TTRAK---GTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTL 739
Cdd:PRK09470 378 SVDKDG--LTITVDDDGPGVPE-EEREQIFRPFYrvdEARDResgGTGLGLAIVENAIQQHRGWVKAEDSPLG-GLRLTI 453
|
...
gi 933521231 740 VVP 742
Cdd:PRK09470 454 WLP 456
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
567-742 |
2.22e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 63.50 E-value: 2.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 567 DDIRRMVDEFSAFARMpqpVMK------PVNI-NDLVRQAVFLQSSAHSGKIRFETRLPQGPLTVACdsrqisqaLTNLL 639
Cdd:COG2972 273 EEAEEMLEALSKLLRY---SLSkgdelvTLEEeLELIKSYLEIQKLRFGDRLEVEIEIDEELLDLLI--------PKLIL 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 640 Q----NAadaIE-GRTPPAEGGElppgeVSIAVEDDGERVVVTVEDNGRGLPgGEQRDRLTEPYvTTRAKGTGLGLAIVK 714
Cdd:COG2972 342 QplveNA---IEhGIEPKEGGGT-----IRISIRKEGDRLVITVEDNGVGMP-EEKLEKLLEEL-SSKGEGRGIGLRNVR 411
|
170 180 190
....*....|....*....|....*....|.
gi 933521231 715 KIMEDHGGM---LTLEDREGGtGARVTLVVP 742
Cdd:COG2972 412 ERLKLYYGEeygLEIESEPGE-GTTVTIRIP 441
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
511-742 |
1.27e-09 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 61.19 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 511 RKAAWADvarrIAHEIKNPLTPIQLSAERLR---RKYLKE--ISSDTEVftmctDTIVRQVDDIRR--MVDEfSAFARMP 583
Cdd:PRK10549 240 RRDFMAD----ISHELRTPLAVLRGELEAIQdgvRKFTPEsvASLQAEV-----GTLTKLVDDLHQlsLSDE-GALAYRK 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 584 QPVmkpvNINDLVRQAV--FLQSSAHSGkIRFETRLPQGpLTVACDSRQISQALTNLLQNAADAIegrtppAEGGELppg 661
Cdd:PRK10549 310 TPV----DLVPLLEVAGgaFRERFASRG-LTLQLSLPDS-ATVFGDPDRLMQLFNNLLENSLRYT------DSGGSL--- 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 662 evSIAVEDDGERVVVTVEDNGRGLpGGEQRDRLTEPYVTT-----RAKG-TGLGLAIVKKIMEDHGGMLTLEDREGGtGA 735
Cdd:PRK10549 375 --HISAEQRDKTLRLTFADSAPGV-SDEQLQKLFERFYRTegsrnRASGgSGLGLAICLNIVEAHNGRIIAAHSPFG-GV 450
|
....*..
gi 933521231 736 RVTLVVP 742
Cdd:PRK10549 451 SITVELP 457
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
332-377 |
1.33e-09 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 53.99 E-value: 1.33e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 933521231 332 VRPISALIGAAERVRAGDLTVRVsEPPGEDEFVLLSRAFNRMTTEI 377
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRV-PVRSKDEIGELARAFNQMAERL 45
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
631-742 |
3.99e-09 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 55.30 E-value: 3.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 631 ISQALTNLLQNAadaiegrtppaeGGELPPGEVSIAVEDDGERVVVTVEDNGRGLPGGEQRDRLTEpyvttrAKGTGLGL 710
Cdd:COG2172 39 VSEAVTNAVRHA------------YGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYST------LAEGGRGL 100
|
90 100 110
....*....|....*....|....*....|..
gi 933521231 711 AIVKKIMEDhggmLTLEDREGGTgaRVTLVVP 742
Cdd:COG2172 101 FLIRRLMDE----VEYESDPGGT--TVRLVKR 126
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
627-742 |
8.93e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 53.62 E-value: 8.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 627 DSRQISQALTNLLQNAADAIEgrtppaEGGELppgEVSIAVEDDGerVVVTVEDNGRGLPGgEQRDRLTEPYVT-----T 701
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTD------TGGKL---RIRAAQTPQE--VRLDVEDSAPGVSD-DQLARLFERFYRvessrN 68
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 933521231 702 RAKG-TGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:cd16946 69 RASGgSGLGLAICHNIALAHGGTISAEHSPLG-GLRLVLTLP 109
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
630-742 |
1.02e-08 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 55.28 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 630 QISQALTNLLQNAAD-AIEGRTPPAEGGELPPGEVSIAVEDDGERVVVTVEDNGRG--------------LPGGEQRDRL 694
Cdd:cd16916 38 KLADPLTHLLRNAVDhGIEAPEERLAAGKPPEGTITLRAEHQGNQVVIEVSDDGRGidrekirekaiergLITADEAATL 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 933521231 695 TE---------PYVTTRAK-----GTGLGLAIVKKIMEDHGGMLTLEDREgGTGARVTLVVP 742
Cdd:cd16916 118 SDdevlnlifaPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTIEVESEP-GQGTTFTIRLP 178
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
522-744 |
1.21e-08 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 58.41 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 522 IAHEIKNPLTPI----------QLSAERlrRKYLKEI--SSDT--EVFTmctDTIvrQVDDI-RRMVDEFsafarmPQPV 586
Cdd:PRK11091 290 ISHELRTPLNGIvglsrilldtELTAEQ--RKYLKTIhvSAITlgNIFN---DII--DMDKMeRRKLQLD------NQPI 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 587 MKPVNINDLVRQAvFLQSSAHSGKIRFETRLPQgPLTVACDSRQISQALTNLLQNAADAIEGrtppaeggelppGEVSIA 666
Cdd:PRK11091 357 DFTDFLADLENLS-GLQAEQKGLRFDLEPLLPL-PHKVITDGTRLRQILWNLISNAVKFTQQ------------GGVTVR 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 667 VE-DDGERVVVTVEDNGRGLPGGEQrDRLTEPYV-------TTRAKGTGLGLAIVKKIMEDHGGMLTLEDREgGTGARVT 738
Cdd:PRK11091 423 VRyEEGDMLTFEVEDSGIGIPEDEL-DKIFAMYYqvkdshgGKPATGTGIGLAVSKRLAQAMGGDITVTSEE-GKGSCFT 500
|
....*.
gi 933521231 739 LVVPHP 744
Cdd:PRK11091 501 LTIHAP 506
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
330-382 |
1.28e-08 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 51.48 E-value: 1.28e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 933521231 330 RLVRPISALIGAAERVRAGDLTVRVsEPPGEDEFVLLSRAFNRMTTEIEGQRR 382
Cdd:smart00304 2 RLLRPLRRLAEAAQRIADGDLTVRL-PVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
505-742 |
1.35e-08 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 56.55 E-value: 1.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 505 ELVSAQRKAAWADVA---RRIAHEIK----NPLTPIQLSAERLRRKYLKEISSDTEVFTMCTDTIVRQVDDIRRMVDEFS 577
Cdd:COG4585 37 ELERELAARAEEAREeerRRIARELHdgvgQSLSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRGLR 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 578 AfarmpqPVMKPVNINDLVRQAVFLQSSAHSGKIRFETRLPQGPLTVACDS---RQISQALTNLLQNAadaiegrtppae 654
Cdd:COG4585 117 P------PALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLPPEVELalyRIVQEALTNALKHA------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 655 ggelPPGEVSIAVEDDGERVVVTVEDNGRGLPggeqrdrltepyvTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGtG 734
Cdd:COG4585 179 ----GATRVTVTLEVDDGELTLTVRDDGVGFD-------------PEAAPGGGLGLRGMRERAEALGGTLTIGSAPGG-G 240
|
....*...
gi 933521231 735 ARVTLVVP 742
Cdd:COG4585 241 TRVRATLP 248
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
627-739 |
1.66e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 52.85 E-value: 1.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 627 DSRQISQALTNLLQNAAD-AIEGRTppaeggelppgeVSIAVEDDGERVVVTVEDNGRGLpGGEQRDRLTEPYVT----- 700
Cdd:cd16975 1 DTLLLSRALINIISNACQyAPEGGT------------VSISIYDEEEYLYFEIWDNGHGF-SEQDLKKALELFYRddtsr 67
|
90 100 110
....*....|....*....|....*....|....*....
gi 933521231 701 TRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTL 739
Cdd:cd16975 68 RSGGHYGMGLYIAKNLVEKHGGSLIIENSQKG-GAEVTV 105
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
391-512 |
1.96e-08 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 57.47 E-value: 1.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 391 LDERRRFTETVLSGVSAGVLGLDADGVINLPNLSAARLLDeEDPDRMVGMPLVELLPD--MGDLLENapkrpGRVVQDQI 468
Cdd:COG3829 6 LKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILG-LPREEVIGKNVTELIPNspLLEVLKT-----GKPVTGVI 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 933521231 469 QirRPGKPTLTLLVRIAAEVRGGDVRGYVVTFDDITELVSAQRK 512
Cdd:COG3829 80 Q--KTGGKGKTVIVTAIPIFEDGEVIGAVETFRDITELKRLERK 121
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
514-582 |
2.32e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 51.06 E-value: 2.32e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 933521231 514 AWADVARRIAHEIKNPLTPIQLSAERLRRKYLKEISSDtevftmCTDTIVRQVDDIRRMVDEFSAFARM 582
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQRE------YLETILRSAERLLRLINDLLDLSRI 63
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
396-728 |
2.51e-08 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 57.15 E-value: 2.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 396 RFTETVLSGVSAGVLGLDADGVINLPNLSAARLLDEEDPDR-MVGMPLVELLpdmgdllenapkRPGRVVQDQI-QIRRP 473
Cdd:PRK15053 222 RQQEALFSSVYEGLIAVDPHGYITAINRNARKMLGLSSPGRqWLGKPIAEVV------------RPADFFTEQIdEKRQD 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 474 GKPTLTLLVRIA--AEVRGGD-VRGYVVTF---DDITELvSAQrkaawadvarriaheiknpLTPIQLSAERLR---RKY 544
Cdd:PRK15053 290 VVANFNGLSVIAnrEAIRSGDdLLGAIISFrskDEISTL-NAQ-------------------LTQIKQYVESLRtlrHEH 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 545 LKEISSDTEVFTMctdtivRQVDDIRRMVDEFSAFARMPQPVMKPVNINDLVRQAVF--LQSSAHSG-KIRFETRLPQGP 621
Cdd:PRK15053 350 LNWMSTLNGLLQM------KEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFgkVQRARELGlKMVIVPGSQLSQ 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 622 LTVACDSRQISQALTNLLQNAADAiEGRTPpaEGGelppGEVSIAVEDDGERVVVTVEDNGRGLPgGEQRDRLTEPYVTT 701
Cdd:PRK15053 424 LPPGLDSTEFAAIVGNLLDNAFEA-SLRSD--EGN----KIVELFLSDEGDDVVIEVADQGCGVP-ESLRDKIFEQGVST 495
|
330 340 350
....*....|....*....|....*....|
gi 933521231 702 RAKGT---GLGLAIVKKIMEDHGGMLTLED 728
Cdd:PRK15053 496 RADEPgehGIGLYLIASYVTRCGGVITLED 525
|
|
| HAMP |
pfam00672 |
HAMP domain; |
327-378 |
3.47e-08 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 50.32 E-value: 3.47e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 933521231 327 FATRLVRPISALIGAAERVRAGDLTVRVsEPPGEDEFVLLSRAFNRMTTEIE 378
Cdd:pfam00672 2 LARRILRPLRRLAEAARRIASGDLDVRL-PVSGRDEIGELARAFNQMAERLR 52
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
519-742 |
3.80e-08 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 56.56 E-value: 3.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 519 ARR-----IAHEIKNPLTPIQLSAE---------RLRRKYLKEISSDTEvfTMctDTIVRQVDDIRRMvdEFSAFARMPQ 584
Cdd:PRK11006 203 ARRnffanVSHELRTPLTVLQGYLEmmqdqplegALREKALHTMREQTQ--RM--EGLVKQLLTLSKI--EAAPTIDLNE 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 585 PVMKPVNINDLVRQAVFLQSSAHsgKIRFETrlpQGPLTVACDSRQISQALTNLLQNAADaiegRTPPaeGGELppgEVS 664
Cdd:PRK11006 277 KVDVPMMLRVLEREAQTLSQGKH--TITFEV---DNSLKVFGNEDQLRSAISNLVYNAVN----HTPE--GTHI---TVR 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 665 IAVEDDGERVvvTVEDNGRGLPGgEQRDRLTEP-YVTTRAK-----GTGLGLAIVKKIMEDHGGMLTLEDrEGGTGARVT 738
Cdd:PRK11006 343 WQRVPQGAEF--SVEDNGPGIAP-EHIPRLTERfYRVDKARsrqtgGSGLGLAIVKHALSHHDSRLEIES-EVGKGTRFS 418
|
....
gi 933521231 739 LVVP 742
Cdd:PRK11006 419 FVLP 422
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
496-742 |
1.77e-07 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 55.13 E-value: 1.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 496 YVVTFDDITE---LVSA----QRKAAWADVARR-----IAHEIKNPLTPIQ-----LSAERLRRKYLKEISSDTEVFTMC 558
Cdd:PRK09959 681 YICGWQDITEtrdLIHAleveRNKAINATVAKSqflatMSHEIRTPISSIMgflelLSGSGLSKEQRVEAISLAYATGQS 760
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 559 TDTIVRQVDDIRRMvdEFSAFARMPQPVMKPVNINDLVRQAVFLQSSaHSGKIRFETRLPQGPLtVACDSRQISQALTNL 638
Cdd:PRK09959 761 LLGLIGEILDVDKI--ESGNYQLQPQWVDIPTLVQNTCHSFGAIAAS-KSIALSCSSTFPDHYL-VKIDPQAFKQVLSNL 836
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 639 LQNAADAiegrtppAEGGELPPGEVSIAVEDDGERVVVTVEDNGRGLPGGEQRD---RLTEPYVTTRAKGTGLGLAIVKK 715
Cdd:PRK09959 837 LSNALKF-------TTEGAVKITTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQlfkRYSQTSAGRQQTGSGLGLMICKE 909
|
250 260
....*....|....*....|....*..
gi 933521231 716 IMEDHGGMLTLEDREgGTGARVTLVVP 742
Cdd:PRK09959 910 LIKNMQGDLSLESHP-GIGTTFTITIP 935
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
523-738 |
2.40e-07 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 53.88 E-value: 2.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 523 AHEIKNPLTP-------IQLSA--ERLRRKYLKEISSDtevftmctdtivrqVDDIRRMVDEFSAFARM-----PQPVmK 588
Cdd:PRK10337 245 AHELRSPLAAlkvqtevAQLSDddPQARKKALLQLHAG--------------IDRATRLVDQLLTLSRLdsldnLQDV-A 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 589 PVNINDLVRQAVFLQ-SSAHSGKIRFETRLPQGPLTVACDSRQISQALTNLLQNAAdaiegRTPPaeggelPPGEVSIAV 667
Cdd:PRK10337 310 EIPLEDLLQSAVMDIyHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAI-----RYSP------QGSVVDVTL 378
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 933521231 668 EDDGervvVTVEDNGRGLpGGEQRDRLTEPYVT---TRAKGTGLGLAIVKKIMEDHGGMLTLEDR-EGGTGARVT 738
Cdd:PRK10337 379 NARN----FTVRDNGPGV-TPEALARIGERFYRppgQEATGSGLGLSIVRRIAKLHGMNVSFGNApEGGFEAKVS 448
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
597-742 |
2.95e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 50.11 E-value: 2.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 597 RQAVFLQSSAHSGKIRFETRLPQGPLTVACDSRqISQALTNLLQNAAD-AIEGRTPpaeggelppGEVSIAVEDDGERVV 675
Cdd:cd16951 7 RIASAINAIHAVGDIRINITGDTGPVSSEVATA-IGLVVNELLQNALKhAFSDREG---------GTITIRSVVDGDYLR 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 933521231 676 VTVEDNGRGLPGGEqrdrltepyvtTRAKGTGLGLAIVKKIMEDHGGMLtLEDREGGTGARVTLVVP 742
Cdd:cd16951 77 ITVIDDGVGLPQDE-----------DWPNKGSLGLQIVRSLVEGELKAF-LEVQSAENGTRVNIDIP 131
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
522-582 |
3.83e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 47.95 E-value: 3.83e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 933521231 522 IAHEIKNPLTPIQLSAERLRRkylKEISSDTEVFtmcTDTIVRQVDDIRRMVDEFSAFARM 582
Cdd:smart00388 9 LSHELRTPLTAIRGYLELLLD---TELSEEQREY---LETILREAERLLRLINDLLDLSRI 63
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
522-742 |
4.22e-07 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 53.24 E-value: 4.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 522 IAHEIKNPLT------PIQLSAERLRRKYLKEISSDTEVFTMCTdtivrqvddirRMVDE--FSAFARMPQ--PVMKPVN 591
Cdd:PRK09835 269 IAHEIRTPITnlitqtEIALSQSRSQKELEDVLYSNLEELTRMA-----------KMVSDmlFLAQADNNQliPEKKMLD 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 592 INDLVRQAV-FLQSSAHSGKIRFetRLPQGPLTVACDSRQISQALTNLLQNAADaiegRTPPAEGgelppgeVSIAVEDD 670
Cdd:PRK09835 338 LADEVGKVFdFFEAWAEERGVEL--RFVGDPCQVAGDPLMLRRAISNLLSNALR----YTPAGEA-------ITVRCQEV 404
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 933521231 671 GERVVVTVEDNGRGLPGgEQRDRL------TEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGTgaRVTLVVP 742
Cdd:PRK09835 405 DHQVQLVVENPGTPIAP-EHLPRLfdrfyrVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGT--RFVISLP 479
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
634-742 |
4.35e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 49.12 E-value: 4.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 634 ALTNLLQNAADaiegRTPPAeggelppGEVSIAVEDDGERVVVTVEDNGRGLPGgEQRDRLTEPYV---TTRAK---GTG 707
Cdd:cd16952 4 AFSNLVSNAVK----YTPPS-------DTITVRWSQEESGARLSVEDTGPGIPP-EHIPRLTERFYrvdIERCRntgGTG 71
|
90 100 110
....*....|....*....|....*....|....*
gi 933521231 708 LGLAIVKKIMEDHGGMLTLEDrEGGTGARVTLVVP 742
Cdd:cd16952 72 LGLAIVKHVMSRHDARLLIAS-ELGKGSRFTCLFP 105
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
144-393 |
4.98e-07 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 53.10 E-value: 4.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 144 TAVNESLVVASAYLHEHQQNIRADALAMANDLSQEARFSSDPERFEQVVATQAMLRTLSEAIVFNGTTGAIVARAGYTFT 223
Cdd:COG0840 21 LLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLALLALAL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 224 LEFEPIPEEKVQQARNGEVALIVKETDDRVRALVSLDRVSDTFLYVGRMVEPRVLQHMASAEGAVKEYTALEnqRGSLQV 303
Cdd:COG0840 101 AALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAAL--ALAAAA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 304 TFTLIFLVVAMLLLLAAVWAGLNFATRLVRPISALIGAAERVRAGDLTVRVsEPPGEDEFVLLSRAFNRMTTEIEGQRRE 383
Cdd:COG0840 179 LALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRI-DVDSKDEIGQLADAFNRMIENLRELVGQ 257
|
250
....*....|
gi 933521231 384 LLSTNRLLDE 393
Cdd:COG0840 258 VRESAEQVAS 267
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
662-739 |
5.64e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 49.17 E-value: 5.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 662 EVSIAVEDDGerVVVTVEDNGRGLPGgEQRDRLTE--PYVTTRAKGTGLGLAIVKKIMEDHGGMLTLED-REGGTGARVT 738
Cdd:cd16954 58 EVTARQTDGG--LHLIVDDDGPGVPE-SQRSKIFQrgQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDsPLGGARFEVV 134
|
.
gi 933521231 739 L 739
Cdd:cd16954 135 F 135
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
513-581 |
1.06e-06 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 46.44 E-value: 1.06e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 933521231 513 AAWADVARRIAHEIKNPLTPIQLSAERLRRKYLkeissDTEVFTMCTDTIVRQVDDIRRMVDEFSAFAR 581
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELL-----DDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
655-741 |
1.70e-06 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 46.88 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 655 GGELPPGEVSIAVEDDGERVVVTVEDNGRGLPggeqRDRLTEPYVTtrAKGTGLGLAIVKKIMEDHGGmltledREGGTG 734
Cdd:cd16936 17 YRHDGPGPVRLELDLDPDRLRVEVTDSGPGFD----PLRPADPDAG--LREGGRGLALIRALMDEVGY------RRTPGG 84
|
....*..
gi 933521231 735 ARVTLVV 741
Cdd:cd16936 85 KTVWLEL 91
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
502-742 |
1.85e-06 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 51.44 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 502 DITELVSAQRKA-AWADVARR--------IAHEIKNPLTPI----QLSAER----LRRKYLKEISSDTEvftmctdTIVR 564
Cdd:PRK11466 422 ELQELVIEHRQArAEAEKASQaksaflaaMSHEIRTPLYGIlgtaQLLADNpalnAQRDDLRAITDSGE-------SLLT 494
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 565 QVDDIRrmvdEFSAFARMPQPVM---KPVNINDLVRQAVFLQSSAHSGK-IRFETRLP-QGPLTVACDSRQISQALTNLL 639
Cdd:PRK11466 495 ILNDIL----DYSAIEAGGKNVSvsdEPFEPRPLLESTLQLMSGRVKGRpIRLATDIAdDLPTALMGDPRRIRQVITNLL 570
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 640 QNAADAIEgrtppaeggelpPGEVSIAVEDDGERVVVTVEDNGRGLPGGEQRDrLTEPYV--TTRAKGTGLGLAIVKKIM 717
Cdd:PRK11466 571 SNALRFTD------------EGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAE-IFQPFVqvSGKRGGTGLGLTISSRLA 637
|
250 260
....*....|....*....|....*
gi 933521231 718 EDHGGMLTLEDREgGTGARVTLVVP 742
Cdd:PRK11466 638 QAMGGELSATSTP-EVGSCFCLRLP 661
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
661-742 |
3.68e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 46.12 E-value: 3.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 661 GEVSIAVEDDGERVVVTVEDNGRGLPgGEQRDRLTEPYVT-----TRAKGTGLGLAIVKKIMEDHGGMLTLEDREgGTGA 735
Cdd:cd16948 25 GKIEIYSETNEQGVVLSIKDFGIGIP-EEDLPRVFDKGFTgengrNFQESTGMGLYLVKKLCDKLGHKIDVESEV-GEGT 102
|
....*..
gi 933521231 736 RVTLVVP 742
Cdd:cd16948 103 TFTITFP 109
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
614-729 |
1.35e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 45.20 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 614 ETRLPQGPLTVACDSRQISQALTNLLQNAAdaiegrTPPAEGGELppgevSIAVEDDGERVVVTVEDNGRGLPGGEQR-- 691
Cdd:cd16947 4 EINIPDRPIYANANTEALQRILKNLISNAI------KYGSDGKFL-----GMTLREDEKHVYIDIWDKGKGISETEKDhv 72
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 933521231 692 -DRL--TEPYVTTRAKGTGLGLAIVKKIMEDHGGMLTLEDR 729
Cdd:cd16947 73 fERLytLEDSRNSAKQGNGLGLTITKRLAESMGGSIYVNSK 113
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
656-740 |
4.06e-05 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 43.82 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 656 GELPPGEVSIAVEDDGERVVVTVEDNGRGLPGGEQRDRLTEPYVTTRAKGtGLGLAIVKKIMEDhggmltLEDREGGTGA 735
Cdd:pfam13581 49 REGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLPPPDLEEPDEDRKEG-GRGLALIRGLMDD------VEYTRGGEGN 121
|
....*
gi 933521231 736 RVTLV 740
Cdd:pfam13581 122 TVRMR 126
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
659-742 |
6.20e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 42.16 E-value: 6.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 659 PPGEVSIAVEDDGERVVVTVEDNGRGLPGGeqrdrltepyvtTRAKGTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVT 738
Cdd:cd16917 17 GASRVRVTLSYTADELTLTVVDDGVGFDGP------------APPGGGGFGLLGMRERAELLGGTLTIGSRPGG-GTRVT 83
|
....
gi 933521231 739 LVVP 742
Cdd:cd16917 84 ARLP 87
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
327-542 |
7.36e-05 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 46.03 E-value: 7.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 327 FATRLVRPISALIGAAERVRAGDLTVRVsEPPGEDEFVLLSRAFNRMTTEIEGQRRELLSTNRLLDERRRFTETVLSGVS 406
Cdd:COG3850 138 LRRRIVRPLRRLTQAAERIARGDFDARV-PVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLL 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 407 AGVLGLDADGVINLPNLSAARLLDEEDPDRMVGMPLVELLPDMGDLLENAPKRPGRVVQDQIQIRRPGKPTLTLLVRIAA 486
Cdd:COG3850 217 AALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELL 296
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 933521231 487 EVRGGDVRGYVVTFDDITELVSAQRKAAWADVARRIAHEIKNPLTPIQLSAERLRR 542
Cdd:COG3850 297 ALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAA 352
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
630-742 |
2.11e-04 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 44.79 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 630 QISQALTNLLQNAAD-AIEgrtPPAE---GGELPPGEVSIAVEDDGERVVVTVEDNGRG--------------LPGGEQR 691
Cdd:COG0643 277 RLGDPLVHLVRNAVDhGIE---TPEErlaAGKPETGTITLSAYHEGGRVVIEVSDDGRGldlekirakaiekgLITAEEA 353
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 933521231 692 DRLTE---------PYVTTRAK-----GTGLGLAIVKKIMEDHGGMLTLEDREGGtGARVTLVVP 742
Cdd:COG0643 354 AALSDeellelifaPGFSTAEEvtdlsGRGVGMDVVKTNIEALGGTIEIESEPGK-GTTFTLRLP 417
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
402-507 |
2.37e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 41.25 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 402 LSGVSAGVLGLDADGVINLPNLSAARLLdEEDPDRMVGMPLVELLPDM-GDLLENAPKR--PGRVVQDQIQIRRPGKPTL 478
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELF-GLPPEELLGKTLAELLPPEdAARLERALRRalEGEEPIDFLEELLLNGEER 79
|
90 100 110
....*....|....*....|....*....|
gi 933521231 479 TLLVRIAA-EVRGGDVRGYVVTFDDITELV 507
Cdd:pfam08448 80 HYELRLTPlRDPDGEVIGVLVISRDITERR 109
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
399-503 |
6.28e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 40.09 E-value: 6.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 399 ETVLSGVSAGVLGLDADGVINLPNLSAARLLdEEDPDRMVGMPLVELLP-----DMGDLLENAPKRPGRVVQDQIQIRRP 473
Cdd:pfam00989 4 RAILESLPDGIFVVDEDGRILYVNAAAEELL-GLSREEVIGKSLLDLIPeeddaEVAELLRQALLQGEESRGFEVSFRVP 82
|
90 100 110
....*....|....*....|....*....|.
gi 933521231 474 GKPTLTLLVRIAAEV-RGGDVRGYVVTFDDI 503
Cdd:pfam00989 83 DGRPRHVEVRASPVRdAGGEILGFLGVLRDI 113
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
629-687 |
1.09e-03 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 41.18 E-value: 1.09e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 933521231 629 RQISQALTNLLQNAADAIEgrtppaEGGELPPGEVSIAvEDDGERVVVTVEDNGRGLPG 687
Cdd:cd16933 18 RSLYTTVRELVENSLDATE------EAGILPDIKVEIE-EIGKDHYKVIVEDNGPGIPE 69
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
634-739 |
1.15e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 38.91 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 634 ALTNLLQNAADAiegrtppaeggELPPGEVSIAVEDDGERVVVTVEDNGRGlPGGEQRDRLTEPYV---TTR-AKGTGLG 709
Cdd:cd16923 4 VFSNLLSNAIKY-----------SPENTRIYITSFLTDDVVNIMFKNPSSH-PLDFKLEKLFERFYrgdNSRnTEGAGLG 71
|
90 100 110
....*....|....*....|....*....|
gi 933521231 710 LAIVKKIMEDHGGMLTLEDREGGTGARVTL 739
Cdd:cd16923 72 LSIAKAIIELHGGSASAEYDDNHDLFKVRL 101
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
389-512 |
1.16e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 41.55 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 389 RLLDERRRFTETVLSGVSAGVLGLDADGVINLPNLSAARLLDEeDPDRMVGMPLVELLPDMGDLLENAP----KRPGRVV 464
Cdd:COG2202 4 EALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGY-SAEELLGKTLRDLLPPEDDDEFLELlraaLAGGGVW 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 933521231 465 QDQIQIRRPGKPTLTLLVRIAAEV-RGGDVRGYVVTFDDITELVSAQRK 512
Cdd:COG2202 83 RGELRNRRKDGSLFWVELSISPVRdEDGEITGFVGIARDITERKRAEEA 131
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
389-512 |
2.00e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 40.78 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 389 RLLDERRRFTETVLSgVSAGVLGLDADGVINLPNLSAARLLdEEDPDRMVGMPLVELLP-----DMGDLLENAPKRPGRV 463
Cdd:COG2202 131 ALRESEERLRLLVEN-APDGIFVLDLDGRILYVNPAAEELL-GYSPEELLGKSLLDLLHpedreRLLELLRRLLEGGRES 208
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 933521231 464 VQDQIQIRRPGKPTLTLLVRIAAEVRGGDVRGYVVTFDDITELVSAQRK 512
Cdd:COG2202 209 YELELRLKDGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEA 257
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
618-742 |
2.09e-03 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 41.50 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 618 PQGPLTVACDSRQISQALTNLLQNAADAIEgrtppaeggelpPGEVSIAVEDDGERVVVTVEDNGRGLPGGEQRdRLTEP 697
Cdd:PRK10841 550 PDVPVALNGDPMRLQQVISNLLSNAIKFTD------------TGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVV-RLFDP 616
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 933521231 698 Y------VTTRAKGTGLGLAIVKKIMEDHGGMLTLEDrEGGTGARVTLVVP 742
Cdd:PRK10841 617 FfqvgtgVQRNFQGTGLGLAICEKLINMMDGDISVDS-EPGMGSQFTIRIP 666
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
101-539 |
2.13e-03 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 41.64 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 101 SRLHTRLVLVFSLLAVAPAIIMTVFSTLFFYVGVQSWFSERVRTAVNESLVVASAYLHEHQQNIRADALAMANDLSQEAR 180
Cdd:COG2770 6 LALLLLLLLLLLLLLLAGALLVLALISLRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 181 FSSDPERFEQVVATQAMLRTLSEAIVFNGTTGAIVARAGYTFTLEFEPIPEEKVQQARNGEVALIVKETDDRVRALVSLD 260
Cdd:COG2770 86 ALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 261 RVSDTFLYVGRMVEPRVLQHMASAEGAVKEYTALENQRGSLQVTFTLIFLVVAMLLLLAAVWAGLNFATRLVRPISALIG 340
Cdd:COG2770 166 LALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 341 AAERVRAGDLTVRVsEPPGEDEFVLLSRAFNRMTTEIEGQRRELLSTNRLLDERRRFTETVLSGVSAGVLGLDADGVINL 420
Cdd:COG2770 246 AARRIAAGDLDVRI-PVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 421 PNLSAARLLDEEDPDRMVGMPLVELLPDMGDLLENAPKRPGRVVQDQIQIRRPGKPTLTLLVRIAAEVRGGDVRGYVVTF 500
Cdd:COG2770 325 AAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLL 404
|
410 420 430
....*....|....*....|....*....|....*....
gi 933521231 501 DDITELVSAQRKAAWADVARRIAHEIKNPLTPIQLSAER 539
Cdd:COG2770 405 LELALEELVLALLALALLALAAAAAAAEAAAAALELAAA 443
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
660-742 |
2.52e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 38.20 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 660 PGEVSIAVEDDGERVVVTVEDNGRGLPGgeqrdRLTEPYVTTRAKGTGLGLAIV-KKIMEDHG---GMLTLEDREGGTga 735
Cdd:cd16924 24 KGVVTISALKEDNHVMIEVEDNGRGIDP-----KVLNILGKKPKEGNGIGLYNVhQRLILLFGedyGIHIASEPDKGT-- 96
|
....*..
gi 933521231 736 RVTLVVP 742
Cdd:cd16924 97 RITFTIP 103
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
422-505 |
5.93e-03 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 36.67 E-value: 5.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 933521231 422 NLSAARLLDEeDPDRMVGMPLVELLPDMGD--LLENAPKRPGRVVQDQIQIRRP-GKPTLTLLVRIAAEVRGGDVRGYVV 498
Cdd:pfam13426 8 NDAALRLLGY-TREELLGKSITDLFAEPEDseRLREALREGKAVREFEVVLYRKdGEPFPVLVSLAPIRDDGGELVGIIA 86
|
....*..
gi 933521231 499 TFDDITE 505
Cdd:pfam13426 87 ILRDITE 93
|
|
| |
