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Conserved domains on  [gi|930070494|gb|ALF38625|]
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protein arginine N-methyltransferase 6, partial [Xenopus laevis]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
3-209 5.60e-39

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 134.01  E-value: 5.60e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494   3 MIADTVRTNGYKQAILH--NRCALq*ltVLDVGAGTGILSVFCVQAGATRVYAVEASA-VSQLASHVVTLNGMDNKVKVL 79
Cdd:COG4076   15 MLNDVERNDAFKAAIERvvKPGDV----VLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRIIAANGLSDRITVI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  80 NSPVESAEIPEQVDAIVSEWMGYALMYESMLPSVIYARDKWLKPGGIILPSAADLFIAPINDRVVEsrlDFWnEVKGLYG 159
Cdd:COG4076   91 NADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDA---EGF-EDWQFDG 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 930070494 160 VDMSC--MRPFAHSCIMnKEMAVNLLSPEDVLSFPVRFASLDLNVCTQEEVR 209
Cdd:COG4076  167 FDFRLfgFLLYAEPLLH-LTRLVRTPLLLLLLPTAFDEFPFDLASQRATSAQ 217
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
3-209 5.60e-39

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 134.01  E-value: 5.60e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494   3 MIADTVRTNGYKQAILH--NRCALq*ltVLDVGAGTGILSVFCVQAGATRVYAVEASA-VSQLASHVVTLNGMDNKVKVL 79
Cdd:COG4076   15 MLNDVERNDAFKAAIERvvKPGDV----VLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRIIAANGLSDRITVI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  80 NSPVESAEIPEQVDAIVSEWMGYALMYESMLPSVIYARDKWLKPGGIILPSAADLFIAPINDRVVEsrlDFWnEVKGLYG 159
Cdd:COG4076   91 NADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDA---EGF-EDWQFDG 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 930070494 160 VDMSC--MRPFAHSCIMnKEMAVNLLSPEDVLSFPVRFASLDLNVCTQEEVR 209
Cdd:COG4076  167 FDFRLfgFLLYAEPLLH-LTRLVRTPLLLLLLPTAFDEFPFDLASQRATSAQ 217
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 28-128 6.53e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.66  E-value: 6.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  28 TVLDVGAGTGILSVFCVQAGATRVYAVEASAVS-QLASHVVTLNGMDNkVKVLNSPVESA--EIPEQVDAIVSEWMGYAL 104
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVAlELARKAAAALLADN-VEVLKGDAEELppEADESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|....
gi 930070494 105 MyESMLPSVIYARDKwLKPGGIIL 128
Cdd:cd02440   80 V-EDLARFLEEARRL-LKPGGVLV 101
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 28-130 1.26e-07

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 50.73  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494   28 TVLDVGAGTGILSVFCVQAGATRVYAVEASAVSQLAS-HVVTLNGMDNKVKVLNspveSAEIP-EQVDAIVSEWMGYALM 105
Cdd:pfam06325 164 SVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAkENAELNGVEARLEVYL----PGDLPkEKADVVVANILADPLI 239

                          90       100
                  ....*....|....*....|....*
gi 930070494  106 yesMLPSVIYARdkwLKPGGIILPS 130
Cdd:pfam06325 240 ---ELAPDIYAL---VKPGGYLILS 258
PRK14968 PRK14968
putative methyltransferase; Provisional
 28-128 7.17e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.81  E-value: 7.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  28 TVLDVGAGTGILSVFCVQAGAtRVYAVEAS--AVsQLASHVVTLNGMDN-KVKVLNS----PVESAE----------IPE 90
Cdd:PRK14968  26 RVLEVGTGSGIVAIVAAKNGK-KVVGVDINpyAV-ECAKCNAKLNNIRNnGVEVIRSdlfePFRGDKfdvilfnppyLPT 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 930070494  91 QVDAIVSEWMGYAL--------MYESMLPSViyarDKWLKPGGIIL 128
Cdd:PRK14968 104 EEEEEWDDWLNYALsggkdgreVIDRFLDEV----GRYLKPGGRIL 145
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 28-80 3.79e-04

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 39.22  E-value: 3.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 930070494   28 TVLDVGAGTGILSVFCVQAGA-TRVYAVEAS--AVSQLASHvVTLNGMDNkVKVLN 80
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAeGRVIAFEPLpdAYEILEEN-VKLNNLPN-VVLLN 54
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
3-209 5.60e-39

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 134.01  E-value: 5.60e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494   3 MIADTVRTNGYKQAILH--NRCALq*ltVLDVGAGTGILSVFCVQAGATRVYAVEASA-VSQLASHVVTLNGMDNKVKVL 79
Cdd:COG4076   15 MLNDVERNDAFKAAIERvvKPGDV----VLDIGTGSGLLSMLAARAGAKKVYAVEVNPdIAAVARRIIAANGLSDRITVI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  80 NSPVESAEIPEQVDAIVSEWMGYALMYESMLPSVIYARDKWLKPGGIILPSAADLFIAPINDRVVEsrlDFWnEVKGLYG 159
Cdd:COG4076   91 NADATDLDLPEKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDA---EGF-EDWQFDG 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 930070494 160 VDMSC--MRPFAHSCIMnKEMAVNLLSPEDVLSFPVRFASLDLNVCTQEEVR 209
Cdd:COG4076  167 FDFRLfgFLLYAEPLLH-LTRLVRTPLLLLLLPTAFDEFPFDLASQRATSAQ 217
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 28-128 2.98e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 53.78  E-value: 2.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  28 TVLDVGAGTGILSVFCVQAGATRVYAVEASAVS-QLASHVVTLNGMDNKVKVLNSPVESAEIPEQVDAIVS----EWMGY 102
Cdd:COG2230   54 RVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQlEYARERAAEAGLADRVEVRLADYRDLPADGQFDAIVSigmfEHVGP 133

                         90       100
                 ....*....|....*....|....*.
gi 930070494 103 ALmYESMLPSViyarDKWLKPGGIIL 128
Cdd:COG2230  134 EN-YPAYFAKV----ARLLKPGGRLL 154
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 20-128 6.16e-09

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 52.33  E-value: 6.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  20 NRCALQ*LTVLDVGAGTGILSVFCVQAGAtRVYAVEAS--AVSQLASHVVTLNgmdnkVKVLNSPVESAEIP-EQVDAIV 96
Cdd:COG2227   19 ARLLPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISpeALEIARERAAELN-----VDFVQGDLEDLPLEdGSFDLVI 92

                         90       100       110
                 ....*....|....*....|....*....|..
gi 930070494  97 SewmGYALMYESMLPSVIYARDKWLKPGGIIL 128
Cdd:COG2227   93 C---SEVLEHLPDPAALLRELARLLKPGGLLL 121
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 28-128 6.53e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.66  E-value: 6.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  28 TVLDVGAGTGILSVFCVQAGATRVYAVEASAVS-QLASHVVTLNGMDNkVKVLNSPVESA--EIPEQVDAIVSEWMGYAL 104
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVDISPVAlELARKAAAALLADN-VEVLKGDAEELppEADESFDVIISDPPLHHL 79

                         90       100
                 ....*....|....*....|....
gi 930070494 105 MyESMLPSVIYARDKwLKPGGIIL 128
Cdd:cd02440   80 V-EDLARFLEEARRL-LKPGGVLV 101
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 28-137 5.53e-08

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 51.30  E-value: 5.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  28 TVLDVGAGTGILSVFCVQ-AGATRVYAVEA-SAVSQLASHVVTLNGMDNKVKVLNSPV---ESAEIPEQVDAIVS----- 97
Cdd:COG4123   40 RVLDLGTGTGVIALMLAQrSPGARITGVEIqPEAAELARRNVALNGLEDRITVIHGDLkefAAELPPGSFDLVVSnppyf 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 930070494  98 -EWMGY-------AL-MYESMLP--SVIYARDKWLKPGG----IILPSAADLFIA 137
Cdd:COG4123  120 kAGSGRkspdearAIaRHEDALTleDLIRAAARLLKPGGrfalIHPAERLAEILA 174
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 28-130 1.26e-07

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 50.73  E-value: 1.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494   28 TVLDVGAGTGILSVFCVQAGATRVYAVEASAVSQLAS-HVVTLNGMDNKVKVLNspveSAEIP-EQVDAIVSEWMGYALM 105
Cdd:pfam06325 164 SVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAAkENAELNGVEARLEVYL----PGDLPkEKADVVVANILADPLI 239

                          90       100
                  ....*....|....*....|....*
gi 930070494  106 yesMLPSVIYARdkwLKPGGIILPS 130
Cdd:pfam06325 240 ---ELAPDIYAL---VKPGGYLILS 258
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 29-125 2.71e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 47.17  E-value: 2.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494   29 VLDVGAGTGILSVFCVQAGATRVYAVEASAVS-QLASHVVTLNGMdnKVKVLNSPVESAEIP-EQVDAIVSeWMGYALMY 106
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMlERARERAAEAGL--NVEFVQGDAEDLPFPdGSFDLVVS-SGVLHHLP 77

                          90       100
                  ....*....|....*....|.
gi 930070494  107 ESMLPSVI--YARdkWLKPGG 125
Cdd:pfam13649  78 DPDLEAALreIAR--VLKPGG 96
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
28-97 5.29e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 48.36  E-value: 5.29e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 930070494  28 TVLDVGAGTGILSVFCVQAGATRVYAVEA--SAVSQLASHvvtLNGMDNKVKVLNSPVESAEIPEQVDAIVS 97
Cdd:COG2263   48 TVLDLGCGTGMLAIGAALLGAKKVVGVDIdpEALEIAREN---AERLGVRVDFIRADVTRIPLGGSVDTVVM 116
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
28-96 6.99e-07

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 48.63  E-value: 6.99e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  28 TVLDVGAGTGILSVFCVQAGATRVYAVEASAVSQLASHV-VTLNGMDNKVKVLNSPVESaeiPEQVDAIV 96
Cdd:COG2264  151 TVLDVGCGSGILAIAAAKLGAKRVLAVDIDPVAVEAAREnAELNGVEDRIEVVLGDLLE---DGPYDLVV 217
PRMT5 pfam05185
PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding ...
 6-101 1.59e-06

PRMT5 arginine-N-methyltransferase; The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.


Pssm-ID: 428356  Cd Length: 171  Bit Score: 46.43  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494    6 DTVRTNGYKQAIlhnRCALQ-----------*LTVLDVGAGTGILsVFCV-QAGAT-----RVYAVEA--SAVSQLaSHV 66
Cdd:pfam05185  36 DPVKYDLYERAI---EKALSdrvpekkktskLLVILVVGAGRGPL-VDRAlRAAEEtgtkvKIYAVEKnpNAYVTL-QKR 110

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 930070494   67 VTLNGMDNKVKVLNSPVESAEIPEQVDAIVSEWMG 101
Cdd:pfam05185 111 INFEKWGDKVTIISSDMREWQGPEKADILVSELLG 145
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 28-97 1.85e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 46.72  E-value: 1.85e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 930070494  28 TVLDVGAGTGILSVFCVQAGA-TRVYAVEASAVS-QLASHVVTLNGMDNkVKVLNSPVESAEIPEQVDAIVS 97
Cdd:COG2813   52 RVLDLGCGYGVIGLALAKRNPeARVTLVDVNARAvELARANAAANGLEN-VEVLWSDGLSGVPDGSFDLILS 122
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 17-147 4.57e-05

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 42.38  E-value: 4.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  17 ILHNRcaLQ*LTVLDVGAGTGILSvfcVQA---GATRVYAVEAS--AVSQLASHVVTLnGMDNKVKVLNSPVESA---EI 88
Cdd:COG0742   35 ILGPD--IEGARVLDLFAGSGALG---LEAlsrGAASVVFVEKDrkAAAVIRKNLEKL-GLEDRARVIRGDALRFlkrLA 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 930070494  89 PEQVDAIvseWMG--YAL-MYESMLPSViyARDKWLKPGGIIL---PSAADLFIAPINDRVVESR 147
Cdd:COG0742  109 GEPFDLV---FLDppYAKgLLEKALELL--AENGLLAPGGLIVvehSKREELPELPAGLELLKER 168
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 28-128 6.49e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 41.52  E-value: 6.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  28 TVLDVGAGTGILSVFCVQAGAtRVYAVEASA--VSQLASHvvtLNGMDNKVKVLNSPVESAEIP-EQVDAIVSewmGYAL 104
Cdd:COG2226   25 RVLDLGCGTGRLALALAERGA-RVTGVDISPemLELARER---AAEAGLNVEFVVGDAEDLPFPdGSFDLVIS---SFVL 97

                         90       100
                 ....*....|....*....|....*.
gi 930070494 105 MYESMLPSVIY--ARdkWLKPGGIIL 128
Cdd:COG2226   98 HHLPDPERALAeiAR--VLKPGGRLV 121
PRK14968 PRK14968
putative methyltransferase; Provisional
 28-128 7.17e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.81  E-value: 7.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  28 TVLDVGAGTGILSVFCVQAGAtRVYAVEAS--AVsQLASHVVTLNGMDN-KVKVLNS----PVESAE----------IPE 90
Cdd:PRK14968  26 RVLEVGTGSGIVAIVAAKNGK-KVVGVDINpyAV-ECAKCNAKLNNIRNnGVEVIRSdlfePFRGDKfdvilfnppyLPT 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 930070494  91 QVDAIVSEWMGYAL--------MYESMLPSViyarDKWLKPGGIIL 128
Cdd:PRK14968 104 EEEEEWDDWLNYALsggkdgreVIDRFLDEV----GRYLKPGGRIL 145
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 30-128 8.30e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 40.34  E-value: 8.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494   30 LDVGAGTGILSVFCVQAGAtRVYAVEASAVsqlASHVVTLNGMDNKVKVLNSPVESAEIP-EQVDAIVSEWmgyALMYES 108
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVDISPE---MLELAREKAPREGLTFVVGDAEDLPFPdNSFDLVLSSE---VLHHVE 73

                          90       100
                  ....*....|....*....|
gi 930070494  109 MLPSVIYARDKWLKPGGIIL 128
Cdd:pfam08241  74 DPERALREIARVLKPGGILI 93
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 28-78 9.44e-05

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 41.79  E-value: 9.44e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 930070494  28 TVLDVGAGTGILSVFCVQAGATRVYAVEasaVSQLASHVVTLNGMDNKVKV 78
Cdd:COG3897   73 RVLELGCGLGLVGIAAAKAGAADVTATD---YDPEALAALRLNAALNGVAI 120
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
28-128 1.01e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 40.19  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  28 TVLDVGAGTGILSVFCVQA--GAtRVYAVEASA--VSQLASHVvtlngmdNKVKVLNSPVESAEIPEQVDAIVSewmGYA 103
Cdd:COG4106    4 RVLDLGCGTGRLTALLAERfpGA-RVTGVDLSPemLARARARL-------PNVRFVVADLRDLDPPEPFDLVVS---NAA 72

                         90       100
                 ....*....|....*....|....*....
gi 930070494 104 LMY----ESMLPSVIyardKWLKPGGIIL 128
Cdd:COG4106   73 LHWlpdhAALLARLA----AALAPGGVLA 97
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 25-134 1.36e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 41.44  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  25 Q*LTVLDVGAGTGILSVFCVQAGATRVYAVEASAVS-QLASHVVTLNGMDN-KVKVLNSPVESAEIPEQVDAIVS----E 98
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAiALARARAAKAGLGNvEFLVADLAELDPLPAESFDLVVAfgvlH 105

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 930070494  99 WMGyalmyESMLPSVIYARDKWLKPGGIILPSAADL 134
Cdd:COG0500  106 HLP-----PEEREALLRELARALKPGGVLLLSASDA 136
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 30-127 3.22e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 38.50  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494   30 LDVGAGTGILSVFCVQAGA-TRVYAVEAS--AVSQLASHVVTLNGMDNKVKVLNSPVESAEIPEQVDAIVsewMGYALMY 106
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPgLEYTGLDISpaALEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVV---ASNVLHH 77

                          90       100
                  ....*....|....*....|.
gi 930070494  107 ESMLPSVIYARDKWLKPGGII 127
Cdd:pfam08242  78 LADPRAVLRNIRRLLKPGGVL 98
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 28-80 3.79e-04

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 39.22  E-value: 3.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 930070494   28 TVLDVGAGTGILSVFCVQAGA-TRVYAVEAS--AVSQLASHvVTLNGMDNkVKVLN 80
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAeGRVIAFEPLpdAYEILEEN-VKLNNLPN-VVLLN 54
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
24-128 5.37e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 39.75  E-value: 5.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  24 LQ*LTVLDVGAGTGILSVFCVQAGATRVY-------AVEASAvsqlasHVVTLNGMDNKVKVlnspvesAEIPEQVDAIV 96
Cdd:PRK00517 118 LPGKTVLDVGCGSGILAIAAAKLGAKKVLavdidpqAVEAAR------ENAELNGVELNVYL-------PQGDLKADVIV 184

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 930070494  97 sewmgyA------LMyesMLPSVIYARdkwLKPGGIIL 128
Cdd:PRK00517 185 ------AnilanpLL---ELAPDLARL---LKPGGRLI 210
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 15-128 8.70e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 39.37  E-value: 8.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  15 QAILHNRCALQ*LTVLDVGAGTGILSV----FCVQAgatRVYAVEAS--AVSQLASHVVTLNGmdNKVKVLNSPVESAEI 88
Cdd:PRK09328  98 EWALEALLLKEPLRVLDLGTGSGAIALalakERPDA---EVTAVDISpeALAVARRNAKHGLG--ARVEFLQGDWFEPLP 172

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 930070494  89 PEQVDAIVS--------EW---MGYALMYEsmlPSV----------IYAR-----DKWLKPGGIIL 128
Cdd:PRK09328 173 GGRFDLIVSnppyipeaDIhllQPEVRDHE---PHLalfggedgldFYRRiieqaPRYLKPGGWLL 235
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
5-128 1.71e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 38.06  E-value: 1.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494   5 ADTVRTNGYK------QAILHNRCALQ*LTVLDVGAGTGILSVFCVQAGaTRVYAVEASA--VSQLASHvvtlnGMDNKV 76
Cdd:COG4976   20 AALVEDLGYEapallaEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG-YRLTGVDLSEemLAKAREK-----GVYDRL 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 930070494  77 KVLNsPVESAEIPEQVDAIVSewmGYALMYESMLPSVIYARDKWLKPGGIIL 128
Cdd:COG4976   94 LVAD-LADLAEPDGRFDLIVA---ADVLTYLGDLAAVFAGVARALKPGGLFI 141
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 23-97 4.11e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 37.44  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494  23 ALQ*LTVLDVGAGTGILSVFCVQA-GATRVYAVEAS--AVsQLASHVVTLNGMDNKVKVLNS----PVESAeipEQVDAI 95
Cdd:COG2890  110 AGAPPRVLDLGTGSGAIALALAKErPDARVTAVDISpdAL-AVARRNAERLGLEDRVRFLQGdlfePLPGD---GRFDLI 185


                 ..
gi 930070494  96 VS 97
Cdd:COG2890  186 VS 187
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
28-96 5.72e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 36.81  E-value: 5.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 930070494  28 TVLDVGAGTGILSVFCVQAGATRVYAVEASA-VSQLAshvvTLNG-----MDNKVKVLNSPVeSAEIP----EQVDAIV 96
Cdd:COG2521  135 RVLDTCTGLGYTAIEALKRGAREVITVEKDPnVLELA----ELNPwsrelANERIKIILGDA-SEVIKtfpdESFDAII 208
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 28-128 6.78e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 36.54  E-value: 6.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930070494   28 TVLDVGAGTGILSVFCVQAGATRVYAVEASAVSQ-LASHVVTLNGMDNKVKVLNSPVEsaEIPEQVDAIVSEWMGYALMY 106
Cdd:pfam02353  64 TLLDIGCGWGGLMRRAAERYDVNVVGLTLSKNQYkLARKRVAAEGLARKVEVLLQDYR--DFDEPFDRIVSVGMFEHVGH 141

                          90       100
                  ....*....|....*....|..
gi 930070494  107 ESmLPSVIYARDKWLKPGGIIL 128
Cdd:pfam02353 142 EN-YDTFFKKLYNLLPPGGLML 162
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 29-97 7.08e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.03  E-value: 7.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 930070494   29 VLDVGAGTGILSVFCVQAGA-TRVYAVEASAVS-QLASHVVTLNGMDNkVKVLNSPVESAEIPEQVDAIVS 97
Cdd:pfam05175  35 VLDLGCGAGVLGAALAKESPdAELTMVDINARAlESARENLAANGLEN-GEVVASDVYSGVEDGKFDLIIS 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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