NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|929654157|dbj|BAA74891|]
View 

KIAA0868 protein [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 70-180 2.74e-33

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 125.54  E-value: 2.74e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   70 GAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGR--YSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVR 147
Cdd:cd00057    33 SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRkgGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVT 112

                          90       100       110
                  ....*....|....*....|....*....|...
gi 929654157  148 HELQHPIIARYVRIVPLDWNgeGRIGLRIEVYG 180
Cdd:cd00057   113 NDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 800-943 3.11e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.22  E-value: 3.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  800 AASFPNPSsYLHFSTFQGE-TSADISFYFKTLTPWGVFLENMGKE--DFIKLELKSATeVSFSFDvgNGPVEIVVRSPTP 876
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGR-LVLRYD--LGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929654157  877 LNDDQWHRVTAERNVKQASLQVDRLPqQIRKAPTEGHTRLELYSQLFVGGAGG---------QQGFLGCIRSLRMN 943
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLPEdlkspglpvSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 216-345 2.94e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 116.37  E-value: 2.94e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   216 FKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSnqlGPIyghTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRS 295
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGS---GPE---SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 929654157   296 MQHFRTN-GEFDYLDLDYEITFGGIP-FSGKPSSSSRKNFKGCMESINYNGV 345
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPpLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1055-1187 1.68e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 1.68e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  1055 FSTTKAPCILLYISSFTTDFLAVLVKpTGSLQIRYNLGGtrEPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSV 1134
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELV-NGRLVLRYDLGS--GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 929654157  1135 SYHLPSSSDTLfNSPKSLFLGKVIETgkiDQEIHKYNTPGFTGCLSRVQFNQI 1187
Cdd:pfam02210   78 SSLPPGESLLL-NLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 375-527 7.64e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.73  E-value: 7.64e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  375 PVFFNATSYLEVPGRLNQDL-FSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQtkmSQIDISSGSGL 453
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTrLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGS---GSLVLSSKTPL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 929654157  454 NDGQWHEVRFLAKENFAILTIDGDeaSAVRTNSP---LQVKTGEKYFFGGfLNQMNNSSHSVLQPSFQGCMQLIQVD 527
Cdd:cd00110    78 NDGQWHSVSVERNGRSVTLSVDGE--RVVESGSPggsALLNLDGPLYLGG-LPEDLKSPGLPVSPGFVGCIRDLKVN 151
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 598-634 1.75e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 54.49  E-value: 1.75e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 929654157  598 SCEAYKHLGQTSN--YYWIDPDGSGPLGPLKVYCNMTED 634
Cdd:NF040941    1 SCWEILQAGPSAPsgVYWIDPDGMGGLAPFQVYCDMTTD 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 555-590 1.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 929654157  555 IDRCVPNH-CEHGGKCSQTWDSFKCTCDEtGYSGATC 590
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
4.1m smart00294
putative band 4.1 homologues' binding motif;
1282-1300 1.49e-05

putative band 4.1 homologues' binding motif;


:

Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.90  E-value: 1.49e-05
                            10
                    ....*....|....*....
gi 929654157   1282 LIRYMFRHKGTYHTNEAKG 1300
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 967-992 8.64e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.64e-03
                           10        20
                   ....*....|....*....|....*.
gi 929654157   967 CTSYgtNCENGGKCLERYHGYSCDCS 992
Cdd:pfam00008    1 CAPN--PCSNGGTCVDTPGGYTCICP 24
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 70-180 2.74e-33

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 125.54  E-value: 2.74e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   70 GAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGR--YSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVR 147
Cdd:cd00057    33 SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRkgGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVT 112

                          90       100       110
                  ....*....|....*....|....*....|...
gi 929654157  148 HELQHPIIARYVRIVPLDWNgeGRIGLRIEVYG 180
Cdd:cd00057   113 NDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 71-178 6.84e-32

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 121.02  E-value: 6.84e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157    71 AGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYS-SSDWVTQYRMLYSDTGRNWKPYHQDGniwaFPGNINSDGVVRHE 149
Cdd:pfam00754   23 NTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDgSNGYVTSYKIEYSLDGENWTTVKDEK----IPGNNDNNTPVTNT 98

                           90       100
                   ....*....|....*....|....*....
gi 929654157   150 LQHPIIARYVRIVPLDWNGEGRIGLRIEV 178
Cdd:pfam00754   99 FDPPIKARYVRIVPTSWNGGNGIALRAEL 127
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 800-943 3.11e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.22  E-value: 3.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  800 AASFPNPSsYLHFSTFQGE-TSADISFYFKTLTPWGVFLENMGKE--DFIKLELKSATeVSFSFDvgNGPVEIVVRSPTP 876
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGR-LVLRYD--LGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929654157  877 LNDDQWHRVTAERNVKQASLQVDRLPqQIRKAPTEGHTRLELYSQLFVGGAGG---------QQGFLGCIRSLRMN 943
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLPEdlkspglpvSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 216-345 2.94e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 116.37  E-value: 2.94e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   216 FKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSnqlGPIyghTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRS 295
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGS---GPE---SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 929654157   296 MQHFRTN-GEFDYLDLDYEITFGGIP-FSGKPSSSSRKNFKGCMESINYNGV 345
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPpLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 187-343 9.48e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 9.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  187 VINFDGHvvLPYRFRNKKMKTLKDVIALNFKTSESEGVILH-GEGQQGDYITLELKKAKLVLSLNLGSnqlgpiyGHTSV 265
Cdd:cd00110     1 GVSFSGS--SYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYaGSQNGGDFLALELEDGRLVLRYDLGS-------GSLVL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  266 MTGSLLDDHHWHSVVIERQGRSINLTLD--RSMQHfRTNGEFDYLDLDYEITFGGIPFSGKPSSS-SRKNFKGCMESINY 342
Cdd:cd00110    72 SSKTPLNDGQWHSVSVERNGRSVTLSVDgeRVVES-GSPGGSALLNLDGPLYLGGLPEDLKSPGLpVSPGFVGCIRDLKV 150


                  .
gi 929654157  343 N 343
Cdd:cd00110   151 N 151
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 34-181 2.63e-29

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 114.14  E-value: 2.63e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157     34 KCDEPLvsGLphVAFSSSSSISGSYSPGYAKINKrGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTqY 113
Cdd:smart00231    1 PCNEPL--GL--ESDSQITASSSYWAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVT-Y 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 929654157    114 RMLYSDTGRNWKPYhQDGNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNgeGRIGLRIEVYGC 181
Cdd:smart00231   75 KLEYSDDGVNWTTY-KDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
LamG smart00282
Laminin G domain;
212-345 2.72e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 2.72e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157    212 IALNFKTSESEGVILH-GEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVmtgsllDDHHWHSVVIERQGRSINL 290
Cdd:smart00282    2 ISFSFRTTSPNGLLLYaGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 929654157    291 TLDRSM-QHFRTNGEFDYLDLDYEITFGGIPFSGKPSSS-SRKNFKGCMESINYNGV 345
Cdd:smart00282   76 SVDGGNrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLpVTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
822-945 1.09e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.05  E-value: 1.09e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157    822 DISFYFKTLTPWGVFLENMGKE--DFIKLELKSATeVSFSFDVGNGPVEIVVrSPTPLNDDQWHRVTAERNVKQASLQVD 899
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGR-LVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 929654157    900 RLPQQIRKAPtEGHTRLELYSQLFVGGAGGQQ---------GFLGCIRSLRMNGV 945
Cdd:smart00282   79 GGNRVSGESP-GGLTILNLDGPLYLGGLPEDLklpplpvtpGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 827-945 3.30e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.89  E-value: 3.30e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   827 FKTLTPWGVFLENMGKE-DFIKLELKSATeVSFSFDVGNGPVEIVVrSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQI 905
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGsDFLALELVNGR-LVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 929654157   906 RKAPTEGHTrLELYSQLFVGGAGG---------QQGFLGCIRSLRMNGV 945
Cdd:pfam02210   79 SLPPGESLL-LNLNGPLYLGGLPPllllpalpvRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1055-1187 1.68e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 1.68e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  1055 FSTTKAPCILLYISSFTTDFLAVLVKpTGSLQIRYNLGGtrEPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSV 1134
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELV-NGRLVLRYDLGS--GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 929654157  1135 SYHLPSSSDTLfNSPKSLFLGKVIETgkiDQEIHKYNTPGFTGCLSRVQFNQI 1187
Cdd:pfam02210   78 SSLPPGESLLL-NLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 375-527 7.64e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.73  E-value: 7.64e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  375 PVFFNATSYLEVPGRLNQDL-FSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQtkmSQIDISSGSGL 453
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTrLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGS---GSLVLSSKTPL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 929654157  454 NDGQWHEVRFLAKENFAILTIDGDeaSAVRTNSP---LQVKTGEKYFFGGfLNQMNNSSHSVLQPSFQGCMQLIQVD 527
Cdd:cd00110    78 NDGQWHSVSVERNGRSVTLSVDGE--RVVESGSPggsALLNLDGPLYLGG-LPEDLKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1050-1185 1.20e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 100.49  E-value: 1.20e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   1050 EIRFSFSTTKAPCILLYISSF-TTDFLAVLVKpTGSLQIRYNLGGTrePYNIDVDHRNMANGQPHSVNITRHEKTIFLKL 1128
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKgGGDYLALELR-DGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 929654157   1129 DHYPSVSYHLPSSSDTLfNSPKSLFLGKVIETGKIDQEIhkyNTPGFTGCLSRVQFN 1185
Cdd:smart00282   78 DGGNRVSGESPGGLTIL-NLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
396-529 1.99e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 100.11  E-value: 1.99e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157    396 SVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKmsqIDISSGSG-LNDGQWHEVRFLAKENFAILTI 474
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGP---ARLTSDPTpLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 929654157    475 DGDEASAVRTNSPLQV-KTGEKYFFGGFLNQMNNsSHSVLQPSFQGCMQLIQVDDQ 529
Cdd:smart00282   78 DGGNRVSGESPGGLTIlNLDGPLYLGGLPEDLKL-PPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1041-1185 1.67e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.87  E-value: 1.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157 1041 NSHPDLAQEEIRFSFSTTKAPCILLYISSFT-TDFLAVLVKpTGSLQIRYNLGgtREPYNIDVDHRnMANGQPHSVNITR 1119
Cdd:cd00110    14 TLPAPRTRLSISFSFRTTSPNGLLLYAGSQNgGDFLALELE-DGRLVLRYDLG--SGSLVLSSKTP-LNDGQWHSVSVER 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929654157 1120 HEKTIFLKLDHYPSVSYHLPSSSDTLfNSPKSLFLGKVIETGKIDQEIhkyNTPGFTGCLSRVQFN 1185
Cdd:cd00110    90 NGRSVTLSVDGERVVESGSPGGSALL-NLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 401-529 6.54e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 95.56  E-value: 6.54e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   401 FRTWNPNGLLVFSHFADNlGNVEIDLTESKVGVHINITQTKMSQIdiSSGSGLNDGQWHEVRFLAKENFAILTIDGDEAS 480
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDLGSGPESLL--SSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 929654157   481 AVRTNS-PLQVKTGEKYFFGGfLNQMNNSSHSVLQPSFQGCMQLIQVDDQ 529
Cdd:pfam02210   78 SSLPPGeSLLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 598-634 1.75e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 54.49  E-value: 1.75e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 929654157  598 SCEAYKHLGQTSN--YYWIDPDGSGPLGPLKVYCNMTED 634
Cdd:NF040941    1 SCWEILQAGPSAPsgVYWIDPDGMGGLAPFQVYCDMTTD 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 555-590 1.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 929654157  555 IDRCVPNH-CEHGGKCSQTWDSFKCTCDEtGYSGATC 590
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
4.1m smart00294
putative band 4.1 homologues' binding motif;
1282-1300 1.49e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.90  E-value: 1.49e-05
                            10
                    ....*....|....*....
gi 929654157   1282 LIRYMFRHKGTYHTNEAKG 1300
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 558-589 2.78e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 2.78e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 929654157   558 CVPNHCEHGGKCSQTWDSFKCTCDEtGYSGAT 589
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPE-GYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
555-590 4.48e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.48e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 929654157    555 IDRCVPNH-CEHGGKCSQTWDSFKCTCDEtGYS-GATC 590
Cdd:smart00179    2 IDECASGNpCQNGGTCVNTVGSYRCECPP-GYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 967-992 8.64e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.64e-03
                           10        20
                   ....*....|....*....|....*.
gi 929654157   967 CTSYgtNCENGGKCLERYHGYSCDCS 992
Cdd:pfam00008    1 CAPN--PCSNGGTCVDTPGGYTCICP 24
COLFI pfam01410
Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 609-632 8.74e-03

Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 460199  Cd Length: 233  Bit Score: 39.25  E-value: 8.74e-03
                           10        20
                   ....*....|....*....|....
gi 929654157   609 SNYYWIDPDGSGPLGPLKVYCNMT 632
Cdd:pfam01410   45 SGEYWIDPNQGCTRDAIKVFCNFE 68
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 70-180 2.74e-33

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 125.54  E-value: 2.74e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   70 GAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGR--YSSSDWVTQYRMLYSDTGRNWKPYHQDGNIWAFPGNINSDGVVR 147
Cdd:cd00057    33 SDNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGRkgGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKVFTGNSDGSTPVT 112

                          90       100       110
                  ....*....|....*....|....*....|...
gi 929654157  148 HELQHPIIARYVRIVPLDWNgeGRIGLRIEVYG 180
Cdd:cd00057   113 NDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 71-178 6.84e-32

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 121.02  E-value: 6.84e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157    71 AGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYS-SSDWVTQYRMLYSDTGRNWKPYHQDGniwaFPGNINSDGVVRHE 149
Cdd:pfam00754   23 NTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQDgSNGYVTSYKIEYSLDGENWTTVKDEK----IPGNNDNNTPVTNT 98

                           90       100
                   ....*....|....*....|....*....
gi 929654157   150 LQHPIIARYVRIVPLDWNGEGRIGLRIEV 178
Cdd:pfam00754   99 FDPPIKARYVRIVPTSWNGGNGIALRAEL 127
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 800-943 3.11e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 120.22  E-value: 3.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  800 AASFPNPSsYLHFSTFQGE-TSADISFYFKTLTPWGVFLENMGKE--DFIKLELKSATeVSFSFDvgNGPVEIVVRSPTP 876
Cdd:cd00110     1 GVSFSGSS-YVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQNggDFLALELEDGR-LVLRYD--LGSGSLVLSSKTP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929654157  877 LNDDQWHRVTAERNVKQASLQVDRLPqQIRKAPTEGHTRLELYSQLFVGGAGG---------QQGFLGCIRSLRMN 943
Cdd:cd00110    77 LNDGQWHSVSVERNGRSVTLSVDGER-VVESGSPGGSALLNLDGPLYLGGLPEdlkspglpvSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 216-345 2.94e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 116.37  E-value: 2.94e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   216 FKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSnqlGPIyghTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRS 295
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGS---GPE---SLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 929654157   296 MQHFRTN-GEFDYLDLDYEITFGGIP-FSGKPSSSSRKNFKGCMESINYNGV 345
Cdd:pfam02210   75 TVVSSLPpGESLLLNLNGPLYLGGLPpLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 187-343 9.48e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 9.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  187 VINFDGHvvLPYRFRNKKMKTLKDVIALNFKTSESEGVILH-GEGQQGDYITLELKKAKLVLSLNLGSnqlgpiyGHTSV 265
Cdd:cd00110     1 GVSFSGS--SYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYaGSQNGGDFLALELEDGRLVLRYDLGS-------GSLVL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  266 MTGSLLDDHHWHSVVIERQGRSINLTLD--RSMQHfRTNGEFDYLDLDYEITFGGIPFSGKPSSS-SRKNFKGCMESINY 342
Cdd:cd00110    72 SSKTPLNDGQWHSVSVERNGRSVTLSVDgeRVVES-GSPGGSALLNLDGPLYLGGLPEDLKSPGLpVSPGFVGCIRDLKV 150


                  .
gi 929654157  343 N 343
Cdd:cd00110   151 N 151
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 34-181 2.63e-29

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 114.14  E-value: 2.63e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157     34 KCDEPLvsGLphVAFSSSSSISGSYSPGYAKINKrGGAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTqY 113
Cdd:smart00231    1 PCNEPL--GL--ESDSQITASSSYWAAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVT-Y 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 929654157    114 RMLYSDTGRNWKPYhQDGNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNgeGRIGLRIEVYGC 181
Cdd:smart00231   75 KLEYSDDGVNWTTY-KDGNSKVFPGNSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
LamG smart00282
Laminin G domain;
212-345 2.72e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 113.97  E-value: 2.72e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157    212 IALNFKTSESEGVILH-GEGQQGDYITLELKKAKLVLSLNLGSNQLGPIYGHTSVmtgsllDDHHWHSVVIERQGRSINL 290
Cdd:smart00282    2 ISFSFRTTSPNGLLLYaGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPL------NDGQWHRVAVERNGRSVTL 75

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 929654157    291 TLDRSM-QHFRTNGEFDYLDLDYEITFGGIPFSGKPSSS-SRKNFKGCMESINYNGV 345
Cdd:smart00282   76 SVDGGNrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLpVTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
822-945 1.09e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 112.05  E-value: 1.09e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157    822 DISFYFKTLTPWGVFLENMGKE--DFIKLELKSATeVSFSFDVGNGPVEIVVrSPTPLNDDQWHRVTAERNVKQASLQVD 899
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGggDYLALELRDGR-LVLRYDLGSGPARLTS-DPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 929654157    900 RLPQQIRKAPtEGHTRLELYSQLFVGGAGGQQ---------GFLGCIRSLRMNGV 945
Cdd:smart00282   79 GGNRVSGESP-GGLTILNLDGPLYLGGLPEDLklpplpvtpGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 827-945 3.30e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.89  E-value: 3.30e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   827 FKTLTPWGVFLENMGKE-DFIKLELKSATeVSFSFDVGNGPVEIVVrSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQI 905
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGsDFLALELVNGR-LVLRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 929654157   906 RKAPTEGHTrLELYSQLFVGGAGG---------QQGFLGCIRSLRMNGV 945
Cdd:pfam02210   79 SLPPGESLL-LNLNGPLYLGGLPPllllpalpvRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1055-1187 1.68e-25

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 102.88  E-value: 1.68e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  1055 FSTTKAPCILLYISSFTTDFLAVLVKpTGSLQIRYNLGGtrEPYNIDVDHRNMANGQPHSVNITRHEKTIFLKLDHYPSV 1134
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELV-NGRLVLRYDLGS--GPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 929654157  1135 SYHLPSSSDTLfNSPKSLFLGKVIETgkiDQEIHKYNTPGFTGCLSRVQFNQI 1187
Cdd:pfam02210   78 SSLPPGESLLL-NLNGPLYLGGLPPL---LLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 375-527 7.64e-25

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.73  E-value: 7.64e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  375 PVFFNATSYLEVPGRLNQDL-FSVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQtkmSQIDISSGSGL 453
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTrLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGS---GSLVLSSKTPL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 929654157  454 NDGQWHEVRFLAKENFAILTIDGDeaSAVRTNSP---LQVKTGEKYFFGGfLNQMNNSSHSVLQPSFQGCMQLIQVD 527
Cdd:cd00110    78 NDGQWHSVSVERNGRSVTLSVDGE--RVVESGSPggsALLNLDGPLYLGG-LPEDLKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1050-1185 1.20e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 100.49  E-value: 1.20e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   1050 EIRFSFSTTKAPCILLYISSF-TTDFLAVLVKpTGSLQIRYNLGGTrePYNIDVDHRNMANGQPHSVNITRHEKTIFLKL 1128
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKgGGDYLALELR-DGRLVLRYDLGSG--PARLTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 929654157   1129 DHYPSVSYHLPSSSDTLfNSPKSLFLGKVIETGKIDQEIhkyNTPGFTGCLSRVQFN 1185
Cdd:smart00282   78 DGGNRVSGESPGGLTIL-NLDGPLYLGGLPEDLKLPPLP---VTPGFRGCIRNLKVN 130
LamG smart00282
Laminin G domain;
396-529 1.99e-24

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 100.11  E-value: 1.99e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157    396 SVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKmsqIDISSGSG-LNDGQWHEVRFLAKENFAILTI 474
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGP---ARLTSDPTpLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 929654157    475 DGDEASAVRTNSPLQV-KTGEKYFFGGFLNQMNNsSHSVLQPSFQGCMQLIQVDDQ 529
Cdd:smart00282   78 DGGNRVSGESPGGLTIlNLDGPLYLGGLPEDLKL-PPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1041-1185 1.67e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.87  E-value: 1.67e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157 1041 NSHPDLAQEEIRFSFSTTKAPCILLYISSFT-TDFLAVLVKpTGSLQIRYNLGgtREPYNIDVDHRnMANGQPHSVNITR 1119
Cdd:cd00110    14 TLPAPRTRLSISFSFRTTSPNGLLLYAGSQNgGDFLALELE-DGRLVLRYDLG--SGSLVLSSKTP-LNDGQWHSVSVER 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929654157 1120 HEKTIFLKLDHYPSVSYHLPSSSDTLfNSPKSLFLGKVIETGKIDQEIhkyNTPGFTGCLSRVQFN 1185
Cdd:cd00110    90 NGRSVTLSVDGERVVESGSPGGSALL-NLDGPLYLGGLPEDLKSPGLP---VSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 401-529 6.54e-23

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 95.56  E-value: 6.54e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   401 FRTWNPNGLLVFSHFADNlGNVEIDLTESKVGVHINITQTKMSQIdiSSGSGLNDGQWHEVRFLAKENFAILTIDGDEAS 480
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDLGSGPESLL--SSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 929654157   481 AVRTNS-PLQVKTGEKYFFGGfLNQMNNSSHSVLQPSFQGCMQLIQVDDQ 529
Cdd:pfam02210   78 SSLPPGeSLLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
827-948 1.96e-18

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 82.75  E-value: 1.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   827 FKTLTPWGVFLENMGKE--DFIKLELKSAtEVSFSFDVGNGPVeiVVRSPTPLNDDQWHRVTAERNVKQASLQVDRLPQQ 904
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDG-RLEVSYDLGSGAA--VVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 929654157   905 IRKAPTEGHTRLELYSQLFVGGAGG----------QQGFLGCIRSLRMNGVTLD 948
Cdd:pfam00054   78 TGESPLGATTDLDVDGPLYVGGLPSlgvkkrrlaiSPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
216-347 4.06e-18

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 81.98  E-value: 4.06e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   216 FKTSESEGVILHGEGQ-QGDYITLELKKAKLVLSLNLGSnqlgpiyGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLD- 293
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQtERDFLALELRDGRLEVSYDLGS-------GAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDg 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 929654157   294 RSMQHFRTNGEFDY-LDLDYEITFGGIPFSGKPSS--SSRKNFKGCMESINYNGVNI 347
Cdd:pfam00054   74 EARPTGESPLGATTdLDVDGPLYVGGLPSLGVKKRrlAISPSFDGCIRDVIVNGKPL 130
Laminin_G_1 pfam00054
Laminin G domain;
401-532 1.32e-12

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 66.19  E-value: 1.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157   401 FRTWNPNGLLVFSHFADNLGNVEIDLTESKVGVHINITQTKMSqidISSGSGLNDGQWHEVRflAKENFAILTIDGDEAS 480
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAV---VRSGDKLNDGKWHSVE--LERNGRSGTLSVDGEA 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 929654157   481 AVRTNSPL----QVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVN 532
Cdd:pfam00054   76 RPTGESPLgattDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 598-634 1.75e-09

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 54.49  E-value: 1.75e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 929654157  598 SCEAYKHLGQTSN--YYWIDPDGSGPLGPLKVYCNMTED 634
Cdd:NF040941    1 SCWEILQAGPSAPsgVYWIDPDGMGGLAPFQVYCDMTTD 39
Laminin_G_1 pfam00054
Laminin G domain;
1055-1185 3.13e-09

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 56.56  E-value: 3.13e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654157  1055 FSTTKAPCILLYISSFT-TDFLAV-LVKptGSLQIRYNLGGTREPYNIDVdhrNMANGQPHSVNITRHEKTIFLKLDHYP 1132
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTeRDFLALeLRD--GRLEVSYDLGSGAAVVRSGD---KLNDGKWHSVELERNGRSGTLSVDGEA 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 929654157  1133 SVSYHLPSSSDTLFNSPKSLFLGKVieTGKIDQEIHKYNTPGFTGCLSRVQFN 1185
Cdd:pfam00054   76 RPTGESPLGATTDLDVDGPLYVGGL--PSLGVKKRRLAISPSFDGCIRDVIVN 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 555-590 1.81e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.81e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 929654157  555 IDRCVPNH-CEHGGKCSQTWDSFKCTCDEtGYSGATC 590
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
4.1m smart00294
putative band 4.1 homologues' binding motif;
1282-1300 1.49e-05

putative band 4.1 homologues' binding motif;


Pssm-ID: 128590  Cd Length: 19  Bit Score: 42.90  E-value: 1.49e-05
                            10
                    ....*....|....*....
gi 929654157   1282 LIRYMFRHKGTYHTNEAKG 1300
Cdd:smart00294    1 MYRYKHRDEGSYHTHEPKG 19
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 558-589 2.78e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 2.78e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 929654157   558 CVPNHCEHGGKCSQTWDSFKCTCDEtGYSGAT 589
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPE-GYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
555-590 4.48e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 4.48e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 929654157    555 IDRCVPNH-CEHGGKCSQTWDSFKCTCDEtGYS-GATC 590
Cdd:smart00179    2 IDECASGNpCQNGGTCVNTVGSYRCECPP-GYTdGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 560-590 1.73e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 1.73e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 929654157  560 PNHCEHGGKCSQTWDSFKCTCDEtGYSGA-TC 590
Cdd:cd00053     5 SNPCSNGGTCVNTPGSYRCVCPP-GYTGDrSC 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 967-992 8.64e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 8.64e-03
                           10        20
                   ....*....|....*....|....*.
gi 929654157   967 CTSYgtNCENGGKCLERYHGYSCDCS 992
Cdd:pfam00008    1 CAPN--PCSNGGTCVDTPGGYTCICP 24
COLFI pfam01410
Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 609-632 8.74e-03

Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 460199  Cd Length: 233  Bit Score: 39.25  E-value: 8.74e-03
                           10        20
                   ....*....|....*....|....
gi 929654157   609 SNYYWIDPDGSGPLGPLKVYCNMT 632
Cdd:pfam01410   45 SGEYWIDPNQGCTRDAIKVFCNFE 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH