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Conserved domains on  [gi|927819981|gb|ALE30480|]
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RID-beta [Simian adenovirus 17]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adeno_E3_14_5 super family cl04788
Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. ...
 26-80 4.19e-03

Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. It is an integral membrane protein oriented with its C terminus in the cytoplasm. It functions to down-regulate the epidermal growth factor receptor and prevent tumour necrosis factor cytolysis. It achieves this through the interaction with E3 10.4 kDa protein.


The actual alignment was detected with superfamily member pfam04834:

Pssm-ID: 461451  Cd Length: 100  Bit Score: 33.90  E-value: 4.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 927819981   26 LACYTAIPDAHPFWLYAIIFLLVFFSTVLGLKIYACLRVGW-IHPREDLPRFPSPA 80
Cdd:pfam04834  41 LACYNKLDDGSEAIDAAIHPTFPFCATIFALAIIAPIDIGRnAIDAMNEISFFNLA 96
 
Name Accession Description Interval E-value
Adeno_E3_14_5 pfam04834
Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. ...
 26-80 4.19e-03

Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. It is an integral membrane protein oriented with its C terminus in the cytoplasm. It functions to down-regulate the epidermal growth factor receptor and prevent tumour necrosis factor cytolysis. It achieves this through the interaction with E3 10.4 kDa protein.


Pssm-ID: 461451  Cd Length: 100  Bit Score: 33.90  E-value: 4.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 927819981   26 LACYTAIPDAHPFWLYAIIFLLVFFSTVLGLKIYACLRVGW-IHPREDLPRFPSPA 80
Cdd:pfam04834  41 LACYNKLDDGSEAIDAAIHPTFPFCATIFALAIIAPIDIGRnAIDAMNEISFFNLA 96
 
Name Accession Description Interval E-value
Adeno_E3_14_5 pfam04834
Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. ...
 26-80 4.19e-03

Early E3 14.5 kDa protein; The E3B 14.5 kDa was first identified in Human adenovirus type 5. It is an integral membrane protein oriented with its C terminus in the cytoplasm. It functions to down-regulate the epidermal growth factor receptor and prevent tumour necrosis factor cytolysis. It achieves this through the interaction with E3 10.4 kDa protein.


Pssm-ID: 461451  Cd Length: 100  Bit Score: 33.90  E-value: 4.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 927819981   26 LACYTAIPDAHPFWLYAIIFLLVFFSTVLGLKIYACLRVGW-IHPREDLPRFPSPA 80
Cdd:pfam04834  41 LACYNKLDDGSEAIDAAIHPTFPFCATIFALAIIAPIDIGRnAIDAMNEISFFNLA 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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