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Conserved domains on  [gi|927441475|emb|CUH92751|]
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hypothetical protein SD1D_1205 [Herbinix luporum]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10135280)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  12691742|9445404|12200473|10508766
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 6-172 3.48e-37

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


:

Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 128.85  E-value: 3.48e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSE-PKIRSFADILIINDASSDRTEAIAKSY-----NMPLITHVFNLGYGATLQVGYKYAVR 79
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAvLEEGYDYEIIVVDDGSTDGTAEIARELaarvpRVRVIRLSRNFGKGAAVRAGFKAARG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  80 NnykYVIQIDGDGQHSVDNIAHIYRCLHSKDAegntpDIVIGSRFLAGSKAyKISAIKKLSISYFSCLIKKKTGVLITDP 159
Cdd:cd04179   81 D---IVVTMDADLQHPPEDIPKLLEKLLEGGA-----DVVIGSRFVRGGGA-GMPLLRRLGSRLFNFLIRLLLGVRISDT 151

                        170
                 ....*....|...
gi 927441475 160 TSGLQGLSRRAFK 172
Cdd:cd04179  152 QSGFRLFRREVLE 164
 
Name Accession Description Interval E-value
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 6-172 3.48e-37

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 128.85  E-value: 3.48e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSE-PKIRSFADILIINDASSDRTEAIAKSY-----NMPLITHVFNLGYGATLQVGYKYAVR 79
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAvLEEGYDYEIIVVDDGSTDGTAEIARELaarvpRVRVIRLSRNFGKGAAVRAGFKAARG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  80 NnykYVIQIDGDGQHSVDNIAHIYRCLHSKDAegntpDIVIGSRFLAGSKAyKISAIKKLSISYFSCLIKKKTGVLITDP 159
Cdd:cd04179   81 D---IVVTMDADLQHPPEDIPKLLEKLLEGGA-----DVVIGSRFVRGGGA-GMPLLRRLGSRLFNFLIRLLLGVRISDT 151

                        170
                 ....*....|...
gi 927441475 160 TSGLQGLSRRAFK 172
Cdd:cd04179  152 QSGFRLFRREVLE 164
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-220 2.88e-31

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 114.41  E-value: 2.88e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   1 MKELLVIVPVFNEEKNLANLLESLSEPKIRSFaDILIINDASSDRTEAIAKSY-----NMPLITHVFNLGYGATLQVGYK 75
Cdd:COG0463    1 MPLVSVVIPTYNEEEYLEEALESLLAQTYPDF-EIIVVDDGSTDGTAEILRELaakdpRIRVIRLERNRGKGAARNAGLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  76 YAvrnNYKYVIQIDGDGQHSVDNIAHIYRCLHSKDAegntpDIVIGSRFLAGSKAYKISAIKKLsISYFSCLIKkktgvl 155
Cdd:COG0463   80 AA---RGDYIAFLDADDQLDPEKLEELVAALEEGPA-----DLVYGSRLIREGESDLRRLGSRL-FNLVRLLTN------ 144

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 927441475 156 ITDPTSGLQGLSRRAFKYYsqygNFDCSYPDANMIIQMLLLGYRIKETTSVMYERKAGVSMHRGL 220
Cdd:COG0463  145 LPDSTSGFRLFRREVLEEL----GFDEGFLEDTELLRALRHGFRIAEVPVRYRAGESKLNLRDLL 205
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 6-172 1.49e-17

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 77.05  E-value: 1.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475    6 VIVPVFNEEKNLANLLESLSEpKIRSFADILIINDASSDRTEAIAKSY-NMP----LITHVFNLGYGATLQVGYKYAvrn 80
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLLN-QTYPNFEIIVVDDGSTDGTVEIAEEYaKKDprvrVIRLPENRGKAGARNAGLRAA--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   81 NYKYVIQIDGDGQHSVDNIAHIYrclhsKDAEGNTPDIVIGSRFLAGSKAYKISAIKKLSISYFSC-LIKKKTGVLITDP 159
Cdd:pfam00535  78 TGDYIAFLDADDEVPPDWLEKLV-----EALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFfLGLRLLGLNLPFL 152

                         170
                  ....*....|...
gi 927441475  160 TSGLQGLSRRAFK 172
Cdd:pfam00535 153 IGGFALYRREALE 165
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 4-170 1.53e-10

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 60.17  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   4 LLVIVPVFNEEKNLANLL-------ESLSEPKIRSFADILIINDASSDRTEAIAKSY---------NMPLITHVFNLGYG 67
Cdd:PTZ00260  72 LSIVIPAYNEEDRLPKMLketikylESRSRKDPKFKYEIIIVNDGSKDKTLKVAKDFwrqninpniDIRLLSLLRNKGKG 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  68 ATLQVGykyAVRNNYKYVIQIDGDGQHSVDNIAHIYRCLHSKDAEGNTpdIVIGSR--FLAGSKAYKISAIKKLSISYFS 145
Cdd:PTZ00260 152 GAVRIG---MLASRGKYILMVDADGATDIDDFDKLEDIMLKIEQNGLG--IVFGSRnhLVDSDVVAKRKWYRNILMYGFH 226

                        170       180
                 ....*....|....*....|....*
gi 927441475 146 CLIKKKTGVLITDPTSGLQGLSRRA 170
Cdd:PTZ00260 227 FIVNTICGTNLKDTQCGFKLFTRET 251
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 6-54 6.16e-08

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 51.74  E-value: 6.16e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 927441475    6 VIVPVFNEEKNLANLLESLSepKIRSFADILIINDASSDRTEAIAKSYN 54
Cdd:TIGR04283   3 IIIPVLNEAATLPELLADLQ--ALRGDAEVIVVDGGSTDGTVEIARSLG 49
 
Name Accession Description Interval E-value
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 6-172 3.48e-37

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 128.85  E-value: 3.48e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSE-PKIRSFADILIINDASSDRTEAIAKSY-----NMPLITHVFNLGYGATLQVGYKYAVR 79
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAvLEEGYDYEIIVVDDGSTDGTAEIARELaarvpRVRVIRLSRNFGKGAAVRAGFKAARG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  80 NnykYVIQIDGDGQHSVDNIAHIYRCLHSKDAegntpDIVIGSRFLAGSKAyKISAIKKLSISYFSCLIKKKTGVLITDP 159
Cdd:cd04179   81 D---IVVTMDADLQHPPEDIPKLLEKLLEGGA-----DVVIGSRFVRGGGA-GMPLLRRLGSRLFNFLIRLLLGVRISDT 151

                        170
                 ....*....|...
gi 927441475 160 TSGLQGLSRRAFK 172
Cdd:cd04179  152 QSGFRLFRREVLE 164
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-220 2.88e-31

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 114.41  E-value: 2.88e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   1 MKELLVIVPVFNEEKNLANLLESLSEPKIRSFaDILIINDASSDRTEAIAKSY-----NMPLITHVFNLGYGATLQVGYK 75
Cdd:COG0463    1 MPLVSVVIPTYNEEEYLEEALESLLAQTYPDF-EIIVVDDGSTDGTAEILRELaakdpRIRVIRLERNRGKGAARNAGLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  76 YAvrnNYKYVIQIDGDGQHSVDNIAHIYRCLHSKDAegntpDIVIGSRFLAGSKAYKISAIKKLsISYFSCLIKkktgvl 155
Cdd:COG0463   80 AA---RGDYIAFLDADDQLDPEKLEELVAALEEGPA-----DLVYGSRLIREGESDLRRLGSRL-FNLVRLLTN------ 144

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 927441475 156 ITDPTSGLQGLSRRAFKYYsqygNFDCSYPDANMIIQMLLLGYRIKETTSVMYERKAGVSMHRGL 220
Cdd:COG0463  145 LPDSTSGFRLFRREVLEEL----GFDEGFLEDTELLRALRHGFRIAEVPVRYRAGESKLNLRDLL 205
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 6-215 2.80e-22

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 91.06  E-value: 2.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSE--PKIRsfADILIINDASSDRTEAIAKSY-----NMPLITHVFNLGYGATLQVGYKYAV 78
Cdd:cd06442    1 IIIPTYNERENIPELIERLDAalKGID--YEIIVVDDNSPDGTAEIVRELakeypRVRLIVRPGKRGLGSAYIEGFKAAR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  79 RNnykYVIQIDGDGQHSVDNIAHIYRCLHSKDAegntpDIVIGSRFLAGSKAYKISAIKKLsISYFSCLI-KKKTGVLIT 157
Cdd:cd06442   79 GD---VIVVMDADLSHPPEYIPELLEAQLEGGA-----DLVIGSRYVEGGGVEGWGLKRKL-ISRGANLLaRLLLGRKVS 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 927441475 158 DPTSGLQGLSRRAF---------KYYSqygnfdcsypdanmiIQMLLL------GYRIKETTSVMYERKAGVS 215
Cdd:cd06442  150 DPTSGFRAYRREVLeklidslvsKGYK---------------FQLELLvrarrlGYRIVEVPITFVDREHGES 207
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 6-172 1.49e-17

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 77.05  E-value: 1.49e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475    6 VIVPVFNEEKNLANLLESLSEpKIRSFADILIINDASSDRTEAIAKSY-NMP----LITHVFNLGYGATLQVGYKYAvrn 80
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLLN-QTYPNFEIIVVDDGSTDGTVEIAEEYaKKDprvrVIRLPENRGKAGARNAGLRAA--- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   81 NYKYVIQIDGDGQHSVDNIAHIYrclhsKDAEGNTPDIVIGSRFLAGSKAYKISAIKKLSISYFSC-LIKKKTGVLITDP 159
Cdd:pfam00535  78 TGDYIAFLDADDEVPPDWLEKLV-----EALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFfLGLRLLGLNLPFL 152

                         170
                  ....*....|...
gi 927441475  160 TSGLQGLSRRAFK 172
Cdd:pfam00535 153 IGGFALYRREALE 165
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 6-178 3.02e-15

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 71.35  E-value: 3.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSE--PKIRSFADILIINDASSDRTEAIAKSY-----NMPLITHVFNLGYGATLQVGYKYAv 78
Cdd:cd04187    1 IVVPVYNEEENLPELYERLKAvlESLGYDYEIIFVDDGSTDRTLEILRELaardpRVKVIRLSRNFGQQAALLAGLDHA- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  79 RNNykYVIQIDGDGQHSVDNIAHIYRclhsKDAEGNtpDIVIGSRflagsKAYKISAIKKLSISYFSCLIKKKTGVLITD 158
Cdd:cd04187   80 RGD--AVITMDADLQDPPELIPEMLA----KWEEGY--DVVYGVR-----KNRKESWLKRLTSKLFYRLINKLSGVDIPD 146

                        170       180
                 ....*....|....*....|
gi 927441475 159 PTSGLQGLSRRAFKYYSQYG 178
Cdd:cd04187  147 NGGDFRLMDRKVVDALLLLP 166
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 6-139 9.02e-15

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 69.46  E-value: 9.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSEPKIRSFaDILIINDASSDRTEAIAKSYNMPLITHVF-----NLGYGATLQVGYKYAvrn 80
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYPNF-EVIVVDDGSTDGTLEILEEYAKKDPRVIRvineeNQGLAAARNAGLKAA--- 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 927441475  81 NYKYVIQIDGDGQHSVDNIAHIYRCLHSKDaegnTPDIVIGsrflAGSKAYKISAIKKL 139
Cdd:cd00761   77 RGEYILFLDADDLLLPDWLERLVAELLADP----EADAVGG----PGNLLFRRELLEEI 127
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 6-172 2.33e-13

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 66.82  E-value: 2.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESL---SEPKIRSFADILIINDASSDRTEAIAKSY------NMPLITHVFNLGYGATLQVGYKY 76
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEAveyLEERPSFSYEIIVVDDGSKDGTAEVARKLarknpaLIRVLTLPKNRGKGGAVRAGMLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  77 AVRnnyKYVIQIDGDGqhSVDnIAHIYRCLHSKDAEGntPDIVIGSR-FLAGSKAYKISAIKKLsISY-FSCLIKKKTGV 154
Cdd:cd04188   81 ARG---DYILFADADL--ATP-FEELEKLEEALKTSG--YDIAIGSRaHLASAAVVKRSWLRNL-LGRgFNFLVRLLLGL 151

                        170
                 ....*....|....*...
gi 927441475 155 LITDPTSGLQGLSRRAFK 172
Cdd:cd04188  152 GIKDTQCGFKLFTRDAAR 169
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 5-223 2.95e-13

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 67.26  E-value: 2.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   5 LVIVPVFNEEKNLANLLESL-----SEPKIRsfadILIINDASSDRTEAIAKSY--NMPLITHVFNLgyGATLQVGYKYA 77
Cdd:cd02525    3 SIIIPVRNEEKYIEELLESLlnqsyPKDLIE----IIVVDGGSTDGTREIVQEYaaKDPRIRLIDNP--KRIQSAGLNIG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  78 VRN-NYKYVIQIDGDGQHSVDNIAHIYRCLHSKDAegntpDIVIGSRFLAGSKAYKISAIK------KLSISYFSCLIKK 150
Cdd:cd02525   77 IRNsRGDIIIRVDAHAVYPKDYILELVEALKRTGA-----DNVGGPMETIGESKFQKAIAVaqssplGSGGSAYRGGAVK 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 927441475 151 KTGVlitdPTSGLQGLSRRAFKyysQYGNFDCSYP---DANMIIQMLLLGYRI---KETTSVMYERkagvSMHRGLIKQ 223
Cdd:cd02525  152 IGYV----DTVHHGAYRREVFE---KVGGFDESLVrneDAELNYRLRKAGYKIwlsPDIRVYYYPR----STLKKLARQ 219
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 6-111 6.64e-13

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 66.69  E-value: 6.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSE---PKIRsfADILIINDASSDRTEAIAKSY--NMPLITHVF---NLGYGATLQVGYKYA 77
Cdd:COG1215   33 VIIPAYNEEAVIEETLRSLLAqdyPKEK--LEVIVVDDGSTDETAEIARELaaEYPRVRVIErpeNGGKAAALNAGLKAA 110

                         90       100       110
                 ....*....|....*....|....*....|....
gi 927441475  78 vrnNYKYVIQIDGDGQHSVDNIAHIYRCLHSKDA 111
Cdd:COG1215  111 ---RGDIVVFLDADTVLDPDWLRRLVAAFADPGV 141
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 4-170 1.53e-10

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 60.17  E-value: 1.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   4 LLVIVPVFNEEKNLANLL-------ESLSEPKIRSFADILIINDASSDRTEAIAKSY---------NMPLITHVFNLGYG 67
Cdd:PTZ00260  72 LSIVIPAYNEEDRLPKMLketikylESRSRKDPKFKYEIIIVNDGSKDKTLKVAKDFwrqninpniDIRLLSLLRNKGKG 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475  68 ATLQVGykyAVRNNYKYVIQIDGDGQHSVDNIAHIYRCLHSKDAEGNTpdIVIGSR--FLAGSKAYKISAIKKLSISYFS 145
Cdd:PTZ00260 152 GAVRIG---MLASRGKYILMVDADGATDIDDFDKLEDIMLKIEQNGLG--IVFGSRnhLVDSDVVAKRKWYRNILMYGFH 226

                        170       180
                 ....*....|....*....|....*
gi 927441475 146 CLIKKKTGVLITDPTSGLQGLSRRA 170
Cdd:PTZ00260 227 FIVNTICGTNLKDTQCGFKLFTRET 251
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-91 5.80e-10

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 57.31  E-value: 5.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   1 MKELLVIVPVFNEEKNLANLLESLSEPKIRSFaDILIINDASSDRTEAIAKSYNMPLITHVF---NLGYGATLQVGYKYA 77
Cdd:COG1216    2 RPKVSVVIPTYNRPELLRRCLESLLAQTYPPF-EVIVVDNGSTDGTAELLAALAFPRVRVIRnpeNLGFAAARNLGLRAA 80

                         90
                 ....*....|....
gi 927441475  78 vrnNYKYVIQIDGD 91
Cdd:COG1216   81 ---GGDYLLFLDDD 91
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 6-110 2.31e-09

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 55.31  E-value: 2.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSE---PKIrsfaDILIINDASSDRTEAIAKS----YNMPLITHVF--NLGYGATLQVGYKY 76
Cdd:cd06423    1 IIVPAYNEEAVIERTIESLLAldyPKL----EVIVVDDGSTDDTLEILEElaalYIRRVLVVRDkeNGGKAGALNAGLRH 76

                         90       100       110
                 ....*....|....*....|....*....|....
gi 927441475  77 AvrnNYKYVIQIDGDGQHSVDNIAHIYRCLHSKD 110
Cdd:cd06423   77 A---KGDIVVVLDADTILEPDALKRLVVPFFADP 107
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 6-91 3.56e-08

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 52.29  E-value: 3.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLsepkiRSFAD-ILIINDASSDRTEAIAKSYNMPLITHVFNlGYGATLQVGYKYAvrnNYKY 84
Cdd:cd02511    4 VVIITKNEERNIERCLESV-----KWAVDeIIVVDSGSTDRTVEIAKEYGAKVYQRWWD-GFGAQRNFALELA---TNDW 74


                 ....*..
gi 927441475  85 VIQIDGD 91
Cdd:cd02511   75 VLSLDAD 81
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 6-54 6.16e-08

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 51.74  E-value: 6.16e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 927441475    6 VIVPVFNEEKNLANLLESLSepKIRSFADILIINDASSDRTEAIAKSYN 54
Cdd:TIGR04283   3 IIIPVLNEAATLPELLADLQ--ALRGDAEVIVVDGGSTDGTVEIARSLG 49
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 6-59 2.31e-07

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 49.88  E-value: 2.31e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 927441475   6 VIVPVFNEEKNLANLLESLSEPKIRSFaDILIINDASSDRTEAIAKSYNMPLIT 59
Cdd:cd02522    3 IIIPTLNEAENLPRLLASLRRLNPLPL-EIIVVDGGSTDGTVAIARSAGVVVIS 55
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-64 1.23e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 48.05  E-value: 1.23e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 927441475   6 VIVPVFNEEKNLANLLESLSE---PKiRSFaDILIINDASSDRTEAIAKSYNMPLITHVFNL 64
Cdd:cd04192    1 VVIAARNEAENLPRLLQSLSAldyPK-EKF-EVILVDDHSTDGTVQILEFAAAKPNFQLKIL 60
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-53 1.81e-06

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 48.12  E-value: 1.81e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 927441475   3 ELLVIVPVFNEEKNLANLLESLSEPKIRSFaDILIINDASSDRTEAIAKSY 53
Cdd:PRK10073   7 KLSIIIPLYNAGKDFRAFMESLIAQTWTAL-EIIIVNDGSTDNSVEIAKHY 56
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 6-53 2.11e-06

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 47.58  E-value: 2.11e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 927441475   6 VIVPVFNEEKN----LANLLeSLSEPKIRsfADILIINDASSDRTEAIAKSY 53
Cdd:cd06439   33 IIIPAYNEEAVieakLENLL-ALDYPRDR--LEIIVVSDGSTDGTAEIAREY 81
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 6-125 1.10e-05

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 44.49  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSEPKIRSFaDILIINDASSDRTEAIAKSY----NMPLItHVF--NLGYGATlqvgykyAVR 79
Cdd:cd06420    1 LIITTYNRPEALELVLKSVLNQSILPF-EVIIADDGSTEETKELIEEFksqfPIPIK-HVWqeDEGFRKA-------KIR 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 927441475  80 N------NYKYVIQIDGDGQHSVDNIAHiyrclHSKDAEGNTpdIVIGSRFL 125
Cdd:cd06420   72 NkaiaaaKGDYLIFIDGDCIPHPDFIAD-----HIELAEPGV--FLSGSRVL 116
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-85 4.03e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 42.93  E-value: 4.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSEPKIRSFaDILIINDASSDRTEAIAKSYnMPLITHVF---NLGYGATLQVGYKYAvrnNY 82
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSLLAQTYPDF-EVIVVDNASTDGSVELLREL-FPEVRLIRngeNLGFGAGNNQGIREA---KG 75


                 ...
gi 927441475  83 KYV 85
Cdd:cd04186   76 DYV 78
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 6-127 6.76e-05

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 42.76  E-value: 6.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESL--SEPKIRSFaDILIINDASSDRT----EAIAKSY---NMPLITHVFNLGYGATLQVGYKY 76
Cdd:PLN02726  13 IIVPTYNERLNIALIVYLIfkALQDVKDF-EIIVVDDGSPDGTqdvvKQLQKVYgedRILLRPRPGKLGLGTAYIHGLKH 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 927441475  77 AVRNnykYVIQIDGDGQHSVDNIAHIYRCLHSKDAegntpDIVIGSRFLAG 127
Cdd:PLN02726  92 ASGD---FVVIMDADLSHHPKYLPSFIKKQRETGA-----DIVTGTRYVKG 134
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 6-57 2.93e-03

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 37.82  E-value: 2.93e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 927441475   6 VIVPVFNEEKNLANLLESLSEPKIRSFADILIINDASSDRTEAIAKSYNMPL 57
Cdd:cd06913    1 IILPVHNGEQWLDECLESVLQQDFEGTLELSVFNDASTDKSAEIIEKWRKKL 52
GlcNAc-1-P_transferase cd06436
N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1, ...
 6-108 6.04e-03

N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; N-acetyl-glucosamine transferase is responsible for the synthesis of bacteria Poly-beta-1,6-N-acetyl-D-glucosamine (PGA). Poly-beta-1,6-N-acetyl-D-glucosamine is a homopolymer that serves as an adhesion for the maintenance of biofilm structural stability in diverse eubacteria. N-acetyl-glucosamine transferase is the product of gene pgaC. Genetic analysis indicated that all four genes of the pgaABCD locus were required for the PGA production, pgaC being a glycosyltransferase.


Pssm-ID: 133058 [Multi-domain]  Cd Length: 191  Bit Score: 36.59  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 927441475   6 VIVPVFNEEKNLANLLESLSEPKiRSFAdILIINDASSDRTEAIAKSY----NMPLIT-----------HVFNLGYGATL 70
Cdd:cd06436    1 VLVPCLNEEAVIQRTLASLLRNK-PNFL-VLVIDDASDDDTAGIVRLAitdsRVHLLRrhlpnartgkgDALNAAYDQIR 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 927441475  71 QVGYKYAVRNNYKYVIQIDGDGQHSVDNIAHIYRCLHS 108
Cdd:cd06436   79 QILIEEGADPERVIIAVIDADGRLDPNALEAVAPYFSD 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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