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Conserved domains on  [gi|926532221|ref|XP_013815431|]
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major facilitator superfamily domain-containing protein 10 isoform X1 [Apteryx mantelli]

Protein Classification

major facilitator superfamily domain-containing protein 10( domain architecture ID 13024405)

major facilitator superfamily domain-containing protein 10 (MFSD10) may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 25-455 0e+00

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 603.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  25 ITIVFLALLIDLLGFALILPLFPSILDYYSKTEDGFSLSLQHG-VDWFAVMVGMPPERKYNSVLFGGLIGSIFSVLQFFS 103
Cdd:cd17389    1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 104 SPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17389   81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 184 FSLGFTLGPMIGAYLAMEAEK-GEVFFLRSALLALTFAVADLIFIFFLLPETLPkekrvssvtsgfqaavdllsplalfq 262
Cdd:cd17389  161 FSLGFIIGPMIGAYFASFTRSlGEVFFSMPALFALVLALADLLFIFFFLPETLP-------------------------- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 263 fsavtrgrdspseknlQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG 342
Cdd:cd17389  215 ----------------SNLRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPG 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 343 NEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPI 422
Cdd:cd17389  279 KEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPI 358

                        410       420       430
                 ....*....|....*....|....*....|...
gi 926532221 423 LSATVYWLAGAEICFTICSAFFLIPFLLLGSVK 455
Cdd:cd17389  359 VACTVYWLAGSEACYTIGALLFLLPLLLLARLK 391
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 25-455 0e+00

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 603.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  25 ITIVFLALLIDLLGFALILPLFPSILDYYSKTEDGFSLSLQHG-VDWFAVMVGMPPERKYNSVLFGGLIGSIFSVLQFFS 103
Cdd:cd17389    1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 104 SPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17389   81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 184 FSLGFTLGPMIGAYLAMEAEK-GEVFFLRSALLALTFAVADLIFIFFLLPETLPkekrvssvtsgfqaavdllsplalfq 262
Cdd:cd17389  161 FSLGFIIGPMIGAYFASFTRSlGEVFFSMPALFALVLALADLLFIFFFLPETLP-------------------------- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 263 fsavtrgrdspseknlQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG 342
Cdd:cd17389  215 ----------------SNLRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPG 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 343 NEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPI 422
Cdd:cd17389  279 KEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPI 358

                        410       420       430
                 ....*....|....*....|....*....|...
gi 926532221 423 LSATVYWLAGAEICFTICSAFFLIPFLLLGSVK 455
Cdd:cd17389  359 VACTVYWLAGSEACYTIGALLFLLPLLLLARLK 391
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
23-419 2.69e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 100.43  E-value: 2.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  23 RVITIVFLALLIDLLGFALILPLFPSILDYYSKtedgfslslqhgvdwfavmvgmpperkynSVLFGGLIGSIFSVLQFF 102
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGA-----------------------------SPAQAGLVVTAYLLGAAL 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 103 SSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKG-NVSLSTAIIADLHSPKARSKGMAMIG 181
Cdd:COG2814   61 GAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 182 VAFSLGFTLGPMIGAYLAmeaekgEVFFLRSA-LLALTFAVADLIFIFFLLPETLPKEKRvssvtSGFQAAVDLLSPLAL 260
Cdd:COG2814  141 AGLGLGPALGPLLGGLLA------DLFGWRWVfLVNAVLALLALLLLLRLLPESRPAARA-----RLRGSLRELLRRPRL 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 261 FqfsavtrgrdspseknlqnlkILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIK 340
Cdd:COG2814  210 L---------------------LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 926532221 341 PGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARAL 419
Cdd:COG2814  269 RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
60-421 8.07e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.17  E-value: 8.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221   60 FSLSLQHGVDWFAVMVGMPPERKYN---SVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAA 136
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDlgiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  137 SRTFGIFLLSRIIGGISKGNV-SLSTAIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeaekgEVFFLRSALL 215
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA------SLFGWRAAFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  216 ALTFAVAdLIFIFFLLPETLPKEKRVSSVTSGFQAAVDLLSPLalfqfsavtrgrdspseknLQNLKILGLAYFLYLFLF 295
Cdd:pfam07690 156 ILAILSL-LAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL-------------------LRDPVLWLLLALLLFGFA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  296 SGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLS 372
Cdd:pfam07690 216 FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLL 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 926532221  373 VGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGP 421
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
90-234 6.42e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 74.22  E-value: 6.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221   90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLST-AIIADLH 168
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 926532221  169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAVadlifIFFLLPET 234
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL-----LAFLLPET 141
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
96-240 1.14e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 56.85  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  96 FSVLQFFSSPLtgavSDCLGRRPVILM-TVMGLIASYALwAASRTFGIFLLSRIIGGISKGNVS-LSTAIIADLHSPKAR 173
Cdd:PRK11102  39 FAIGQLFYGPM----ADSFGRKPVILGgTLVFALAAVAC-ALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEF 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 926532221 174 SKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSAllaltFAVADLIFIFFLLPETLPKEKR 240
Cdd:PRK11102 114 SRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLAL-----AAILAAALVFFFIPETLPKERR 175
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 25-455 0e+00

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 603.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  25 ITIVFLALLIDLLGFALILPLFPSILDYYSKTEDGFSLSLQHG-VDWFAVMVGMPPERKYNSVLFGGLIGSIFSVLQFFS 103
Cdd:cd17389    1 ITIVFLALLLDLLAFTIILPLFPSLLDYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 104 SPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17389   81 SPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 184 FSLGFTLGPMIGAYLAMEAEK-GEVFFLRSALLALTFAVADLIFIFFLLPETLPkekrvssvtsgfqaavdllsplalfq 262
Cdd:cd17389  161 FSLGFIIGPMIGAYFASFTRSlGEVFFSMPALFALVLALADLLFIFFFLPETLP-------------------------- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 263 fsavtrgrdspseknlQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPG 342
Cdd:cd17389  215 ----------------SNLRRLGLVYFLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPG 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 343 NEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPI 422
Cdd:cd17389  279 KEKKAVLQGLILLIPAFLLIGWASSVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPI 358

                        410       420       430
                 ....*....|....*....|....*....|...
gi 926532221 423 LSATVYWLAGAEICFTICSAFFLIPFLLLGSVK 455
Cdd:cd17389  359 VACTVYWLAGSEACYTIGALLFLLPLLLLARLK 391
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 28-452 4.21e-59

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 197.42  E-value: 4.21e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  28 VFLALLIDLLGFALILPLFPSILDYYSKTEDgfslslqhgvdwfavmvgmpperkynSVLFGGLIGSIFSVLQFFSSPLT 107
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGA--------------------------SGYYVGLLQSSYSLGQFLASPLW 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 108 GAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGVAFSLG 187
Cdd:cd17330   55 GRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLG 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 188 FTLGPMIGAYLAmeaeKGEVFFLrSALLALTFAVADLIFIFFLLPetlpkekrvssvtsgfqaavdllsplalfqfsavt 267
Cdd:cd17330  135 FILGPALGGFLS----TPYGYAL-PFLVAAALALLNLVLVLFFLP----------------------------------- 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 268 rgrdspseknlqNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKP-GNEIR 346
Cdd:cd17330  175 ------------PLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKrLGERK 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 347 AVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPILSAT 426
Cdd:cd17330  243 LLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGP 322

                        410       420
                 ....*....|....*....|....*.
gi 926532221 427 VYWLAGAEICFTICSAFFLIPFLLLG 452
Cdd:cd17330  323 LYSFLGPGVPFLLAAGLLLIALFLLS 348
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 25-428 2.60e-40

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 148.55  E-value: 2.60e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  25 ITIVFLALLIDLLGFALILPLFPSILdyyskteDGFSLSLQHGVDWFavmvgmpperkynsvlfgGLIGSIFSVLQFFSS 104
Cdd:cd17388    1 LIFILVTVLLDAMGIGLIMPVLPTLL-------REFVGDSADAATHY------------------GVLLALYALMQFIFA 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 105 PLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGVAF 184
Cdd:cd17388   56 PILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAF 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 185 SLGFTLGPMIGAYLameaekGEV-----FFLRSALLALTFAVAdlifiFFLLPETLPKEKRVSSVTSGFQaavdllsPLA 259
Cdd:cd17388  136 GLGFIAGPALGGLL------GEIsprapFLVAAGLNGLNFLLG-----LFVLPESLPPERRRAFRWRRAN-------PFG 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 260 LFQFSAVTRGrdspseknlqnLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRI 339
Cdd:cd17388  198 SLRWLTGFPG-----------LLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPI 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 340 KPG-NEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSfAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARA 418
Cdd:cd17388  267 AKRlGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLA-LGGIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSI 345

                        410
                 ....*....|
gi 926532221 419 LGPILSATVY 428
Cdd:cd17388  346 IGPLLFTGIF 355
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 28-424 4.58e-35

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 133.51  E-value: 4.58e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  28 VFLALLIDLLGFALILPLFPSILDYYSKTedgfslslqhgvdwfAVMVGmpperkynsvlfggLIGSIFSVLQFFSSPLT 107
Cdd:cd17390    1 LYLVGFLDLFGVSMILPLLSTHIRSLGAS---------------PTVIG--------------LIGSVYGALQLFSSPLV 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 108 GAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGVAFSLG 187
Cdd:cd17390   52 GSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLG 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 188 FTLGPMIGAYLaMEAEKGevFFLRSALLALTFaVADLIFIFFLLPETLpkekrvssvtsgfqaavDLLSPLALFQFSAvt 267
Cdd:cd17390  132 FILGPVVGGHL-AETDGG--FYYVALLCSAIF-ILNAGLVWFLLSKLW-----------------DLLLVRFLMGFSV-- 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 268 rgrdspseknlqnlkilglayflyLFLFSgleyTLSFLTHQRFQFSSMQQGKMFFFIGItMAVIQGGYARRIK---PGNE 344
Cdd:cd17390  189 ------------------------LLFRS----NFSLYLEERFDLSPKTIGYLISYSGV-LGALSGFLVGRILklyKNNE 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 345 IRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPILS 424
Cdd:cd17390  240 YLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLS 319
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 28-451 1.98e-32

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 126.92  E-value: 1.98e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  28 VFLALLIDLLGFALILPLFPSildyysktedgfslslqhgvdwFAVMVGMpperkynSVLFGGLIGSIFSVLQFFSSPLT 107
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPL----------------------YAESLGA-------SVAQIGLIVAAYALAQLLFSPPA 51

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 108 GAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKG-NVSLSTAIIADLHSPKARSKGMAMIGVAFSL 186
Cdd:cd17325   52 GRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGL 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 187 GFTLGPMIGAYLAMEAEKGEVFFLRSALlaltfAVADLIFIFFLLPETLPKEKRVSSVTSGFQAAVDLLSplalfqfsav 266
Cdd:cd17325  132 GFLIGPLLGGLLADALGYRAPFLVCAAL-----ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLL---------- 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 267 trgrdspsekNLQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIkpgN 343
Cdd:cd17325  197 ----------RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQppaGKLSDRI---G 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 344 EIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPIL 423
Cdd:cd17325  264 RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL 343

                        410       420
                 ....*....|....*....|....*...
gi 926532221 424 SATVYWLAGAEICFTICSAFFLIPFLLL 451
Cdd:cd17325  344 GGFLYDAFGFATPFLAAAALLLLAAVLF 371
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 90-451 2.75e-27

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 112.28  E-value: 2.75e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGI-SKGNVSLSTAIIADLH 168
Cdd:cd17474   37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLF 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAekgevFFLRSALLALTFAVAdLIFIFFLLPETLPKEKRVSSVTSGF 248
Cdd:cd17474  117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS-----WRYPFFLLAALIPVA-FLAILFLLPEPKEKAKSSSATKLRD 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 249 QAAVDLLSPLALFQFSAvtrgrdspseknlqnlkilglayFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 328
Cdd:cd17474  191 LKKALRGRGLLTFLVSA-----------------------FLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 329 AVIQGGYARRIKPGNEIRAV-KRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMG 407
Cdd:cd17474  248 ALGSLFVGRLLKKRFGARRIlVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS 327

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 926532221 408 ILRSLGALARALGPILSATVYWLAGAEICFTICSAFFLIPFLLL 451
Cdd:cd17474  328 LYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
23-419 2.69e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 100.43  E-value: 2.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  23 RVITIVFLALLIDLLGFALILPLFPSILDYYSKtedgfslslqhgvdwfavmvgmpperkynSVLFGGLIGSIFSVLQFF 102
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGA-----------------------------SPAQAGLVVTAYLLGAAL 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 103 SSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKG-NVSLSTAIIADLHSPKARSKGMAMIG 181
Cdd:COG2814   61 GAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 182 VAFSLGFTLGPMIGAYLAmeaekgEVFFLRSA-LLALTFAVADLIFIFFLLPETLPKEKRvssvtSGFQAAVDLLSPLAL 260
Cdd:COG2814  141 AGLGLGPALGPLLGGLLA------DLFGWRWVfLVNAVLALLALLLLLRLLPESRPAARA-----RLRGSLRELLRRPRL 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 261 FqfsavtrgrdspseknlqnlkILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIK 340
Cdd:COG2814  210 L---------------------LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 926532221 341 PGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARAL 419
Cdd:COG2814  269 RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 90-451 8.10e-21

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 93.83  E-value: 8.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNV-SLSTAIIADLH 168
Cdd:cd17329   38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFePASEAMIADVT 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAekgevFFLRSALLALTFAVAdLIFIFFLLPETLPKeKRVSSVTSGF 248
Cdd:cd17329  118 TPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS-----FRLLFLAAAVLFLLA-ALVLLFLLPETRPK-RRAAEKTEIL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 249 QAAVDLLsplalfqfsavtrgrdspsekNLQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 328
Cdd:cd17329  191 RGYKIVL---------------------RDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLI 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 329 AVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGI 408
Cdd:cd17329  250 VLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGF 329

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 926532221 409 LRSLGALARALGPILSATVYWLAGAEICFTICSAFFLIPFLLL 451
Cdd:cd17329  330 YALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALL 372
MFS_1 pfam07690
Major Facilitator Superfamily;
60-421 8.07e-20

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 90.17  E-value: 8.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221   60 FSLSLQHGVDWFAVMVGMPPERKYN---SVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAA 136
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDlgiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  137 SRTFGIFLLSRIIGGISKGNV-SLSTAIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeaekgEVFFLRSALL 215
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALfPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA------SLFGWRAAFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  216 ALTFAVAdLIFIFFLLPETLPKEKRVSSVTSGFQAAVDLLSPLalfqfsavtrgrdspseknLQNLKILGLAYFLYLFLF 295
Cdd:pfam07690 156 ILAILSL-LAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL-------------------LRDPVLWLLLALLLFGFA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  296 SGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLS 372
Cdd:pfam07690 216 FFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLL 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 926532221  373 VGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGP 421
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 84-445 3.45e-19

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 88.82  E-value: 3.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  84 NSVLFGGLIgSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRiIGGISKGNVSLSTAI 163
Cdd:cd17331   33 DSVVFGYLQ-TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR-LPSVFMHAMQAAQMV 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 164 IADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLameAEKGEVFFlrSALLALTFAVADLIFIFFLLPE-TLPKEKRVS 242
Cdd:cd17331  111 VTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLL---TKKFGEQA--AALVAAVGSLLSIVLVILLIPSnTKSKREKEA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 243 SVTSGFQAAVDLLSPLALFQFSAVTRgrdspseknlqnlkiLGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFF 322
Cdd:cd17331  186 KESASPPSVFNLKEILRLLRLPGVAF---------------LLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMS 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 323 FIGITMAVIQGGYARR-IKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQ 401
Cdd:cd17331  251 YAGVLGMVVQGLLVGPlTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPED 330

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 926532221 402 KGRVMGILRSLGALARALGPILSATVY--------WLAGAEICFTICSAFFL 445
Cdd:cd17331  331 TGTALGLSHALFSLVRTVSPTIGGALLqaygfpsfGLLGAAINGLLTVYLLL 382
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 84-430 9.58e-17

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 81.70  E-value: 9.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  84 NSVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSriIGGISKGNVSLSTAI 163
Cdd:cd17387   33 HTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWYFAMIS--VSGIFSVTFSVIFAY 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 164 IADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVfflrsALLALTFAVADLIFIFFLLPETLPKEKRVSS 243
Cdd:cd17387  111 VADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYGDNLV-----VLVATIVALLDICFILLAVPESLPEKMRPAS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 244 VTSGFQ-AAVDLLSPLALFqfsavtrGRDSpseknlqNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFF 322
Cdd:cd17387  186 WGAPISwEQADPFASLRKV-------GKDK-------TVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 323 FIGITMAVIQG--GYARRIKPGNeiravKRAIML-LIPAFLLVGWAANVT----MLSVGLLlySFAAAIVIPCLSAVVSG 395
Cdd:cd17387  252 VVGILSITAQTllLSILMRSIGA-----KNTILLgLGFQMLQLAWYGFGSqhwmMWAAGAV--AAMSSITFPAISALVSR 324

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 926532221 396 YGAASQKGRVMGILRSLGALARALGPILSATVYWL 430
Cdd:cd17387  325 YADPDQQGAVQGMITGIRGLCNGLGPALFGFVFYL 359
2_A_01_02 TIGR00880
Multidrug resistance protein;
90-234 6.42e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 74.22  E-value: 6.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221   90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLST-AIIADLH 168
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 926532221  169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAVadlifIFFLLPET 234
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL-----LAFLLPET 141
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 90-450 9.12e-16

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 78.36  E-value: 9.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNV-SLSTAIIADLH 168
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYAADLV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLameaekGEVFFLRSALLALT-FAVADLIFIFFLLPETLPKEKRVSSVTSG 247
Cdd:cd17324  117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLL------GQLLGWRAAFLAIAvLALLAALLLWRLLPSLPPKKPGSLGLLSS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 248 FQAAVdllsplalfqfsavtrgrdspseKNLQNLKILgLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGIT 327
Cdd:cd17324  191 LLLLL-----------------------RNPRLRLAY-LITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 328 MAV---IQGGYARRIKPGNEIRAvkrAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSgYGAASQKGR 404
Cdd:cd17324  247 GVVgspLAGRLADRGGRRALLIA---LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL-RLAPEARGL 322

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 926532221 405 VMGILRSLGALARALGPILSATVYWLAGAEICFTICSAFFLIPFLL 450
Cdd:cd17324  323 ASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 88-454 3.52e-15

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 76.86  E-value: 3.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  88 FGGLIGSIFSVLQFFSSPLTGAVSDCLG--RRPVILMTVMGLIAS--YALWAASRTFGIF--LLSRIIGGISKGNVSLST 161
Cdd:cd17326   37 FFGWVVAAYSLGQLVFSPVFGYWSNKTSsvKEPLIVSILIAIVGNilYALAEYFPSNRKYvmLVARFLIGVGAGNVAVLR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 162 AIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLR--------SALLALTFAVADLIFIFFLLPE 233
Cdd:cd17326  117 AYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIGYPGYVIGIKlrfnmytaPAWLMAILGIINIILILFFFKE 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 234 TlpkekrvssvtsgfqaavdllsplalfqfsavtrgrdspseknlqnlkILGLAYFLYLFLFSGLEYTLSFLTHQRFQFS 313
Cdd:cd17326  197 V------------------------------------------------VCIFLFFVVLFIFANLETIGTPLTMDMYGWT 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 314 SMQQ----GKMFFFIGITMAVIQGGYarriKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCL 389
Cdd:cd17326  229 REEAvlynGIILAVSGVLSVLVFLLF----KFLSLGLIDERKILLGGLILFFLGFVVTLPWGITGVILFGLGYPIGNVML 304

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 926532221 390 SAVVSGYGAASQKGRVMGILRSLGALARALGPILSATVYWLAGAEICFTICSAFFLIPFLLLGSV 454
Cdd:cd17326  305 YTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLGLLLLAIILLIVF 369
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 90-450 3.90e-14

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 73.40  E-value: 3.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHS 169
Cdd:cd17489   34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 170 PKAR-SKGMAMIGVAFSLGFTLGPMIGAYLAMEAEkgevfFLRSALLALTFAVADLIFIFFLLPETLPKEKRVSSVTSGF 248
Cdd:cd17489  114 PPSRrGEGIGYYGLATTLAMALGPALGLFLYQHLG-----FAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAF 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 249 QAAVD--LLSPLALFQFSAVTRGrdspseknlqnlkilGLAYFLYLFLFS-GLEYTLSFLThqrfqfssmqqgkmffFIG 325
Cdd:cd17489  189 RRLVEkkVLPPALILFLASIAYG---------------AISTFLPLYAAErGISNAGLFFT----------------VYA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 326 ITMAVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRV 405
Cdd:cd17489  238 IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 926532221 406 MGILRSLGALARALGPILSATVYWLAGAEICFTICSAFFLIPFLL 450
Cdd:cd17489  318 NGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 84-451 4.03e-14

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 73.38  E-value: 4.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  84 NSVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVilmtvmgLIASYALWAASRTFGIF-------LLSRIIGGISKGN 156
Cdd:cd17473   32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRL-------LIAGLLLYGIGGVAGLFldslyalLASRALLGIGVAG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 157 V-SLSTAIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeaekgeVFFLRSALLALTFAVADLIFIFFLLPEtl 235
Cdd:cd17473  105 ImTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-------EIGWRAPFLVYLLALPVLILVLLFLPE-- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 236 PKEKRVSSVTSGFQAAVDLLSPLALFqfsavtrgrdspseknlqnlkILGLAYFLYLFLFSGLEYtLSFLTHQRFQFSSM 315
Cdd:cd17473  176 PARKSKSAASPGAATAAALPWKRVLP---------------------IYFLAFLAMLLFYVIPIQ-LPFLLQERGGGSAA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 316 QQGKMFFFIGITMAVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSG 395
Cdd:cd17473  234 LIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMS 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 926532221 396 YGAASQKGRVMGILRSLGALARALGPILSATVYWLA-GAEICFTICSAFFLIPFLLL 451
Cdd:cd17473  314 LVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTgGLSGAFLILGVLALVLAIVL 370
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
90-460 2.41e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.97  E-value: 2.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKG-NVSLSTAIIADLH 168
Cdd:COG2271   48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWF 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeaekgEVFFLRSALLALTFAVADLIFIFFLLpetlpkekrvssvtsgf 248
Cdd:COG2271  128 PPKERGRALGIFNAGGPLGGALAPPLLGWLL------AAFGWRAAFLILGLPGLLLALLRFWL----------------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 249 qaavdllsplalfqfsavtrgrdspseknlqnlkiLGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 328
Cdd:COG2271  185 -----------------------------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAG 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 329 AVIQ--GGY-ARRIKPGNeIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRV 405
Cdd:COG2271  230 IVGSllGGWlSDRLGRRR-KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTA 308

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 926532221 406 MGILRSLGALARALGPILSATVYWLAGAEICFTICSAFFLIPFLLLGSVKQQPKE 460
Cdd:COG2271  309 SGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 90-451 3.81e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 67.45  E-value: 3.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLST-AIIADLH 168
Cdd:cd06174   34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVlALIADLF 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGevffLRSALLALTFAVADLIFIFFLLPETLPKEKRVSSVTSGF 248
Cdd:cd06174  114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG----WRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 249 QAAVDLLSPLALFqfsavtrgrdspseknlQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 328
Cdd:cd06174  190 KSVLKLLKRVLKN-----------------PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 329 AVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGL-LLYSFAAAIVIPCLSAVVSGYGAASQKGRVMG 407
Cdd:cd06174  253 ALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLlLLLGFGLGGLLPLSFALIAELFPPEIRGTAFG 332

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 926532221 408 ILRSLGALARALGPILSATVY-WLAGAEICFTICSAFFLIPFLLL 451
Cdd:cd06174  333 LLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAILL 377
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 96-420 6.18e-12

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 66.83  E-value: 6.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  96 FSVLQFFSSPLtgavSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVS-LSTAIIADLHSPKARS 174
Cdd:cd17320   47 FALGQLLYGPL----SDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSvVARAIVRDLYSGAELA 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 175 KGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFflrsALLALtFAVADLIFIFFLLPETLPKEKRVSSVTSGFQAAVDL 254
Cdd:cd17320  123 KIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIF----VFLAL-LGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRV 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 255 LSPLaLFQFSAVTRGrdspseknlqnlkILGLAYFLYLFlfsgleyTLSFLTHQRFQFSSMQQGKMFFFIGITM---AVI 331
Cdd:cd17320  198 LKNR-RFLGYALALG-------------LSFAGLFAYLA-------AAPFIYIEQLGLSPAQFGLLFALNAIALilgSLL 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 332 QGGYARRIKPGneiRAVKRAIMLLIPAFLLVGWAANVTMLS-----VGLLLYSFAAAIVIP-CLSAVVSGYGaaSQKGRV 405
Cdd:cd17320  257 NGRLVRRFGPR---RLLRLGLLLLLAAALVLLLAALLGGLSlwplvAPLFLIFFGFGLIFPnATSLALEPFP--HVAGTA 331

                        330
                 ....*....|....*
gi 926532221 406 MGILRSLGALARALG 420
Cdd:cd17320  332 SALLGFLQFLIGALA 346
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 84-451 6.24e-12

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 66.87  E-value: 6.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  84 NSVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTV---MGLIASYALWAASRTFG---IFLLSRIIGGISKGNV 157
Cdd:cd06173   31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADllrALLAAVLALLALLGSLSlwlLLVLAFLLGIASAFFG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 158 SLSTAIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFflrsALLALTFAVAdLIFIFFL-LPETLP 236
Cdd:cd06173  111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAF----AINALSFLLS-ALLLLFIrRPPPAA 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 237 KEKRVSSVTSGFQAAVDLLsplalfqfsavtrgrdspseKNLQNLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQ 316
Cdd:cd06173  186 PGESSSLLLRDLREGLRYL--------------------RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 317 QGKMFFFIGITMAVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGY 396
Cdd:cd06173  246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLR 325

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 926532221 397 GAASQKGRVMGILRSLGALARALGPILSATVYWLAGAEICFTICSAFFLIPFLLL 451
Cdd:cd06173  326 VPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
19-461 1.87e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 65.65  E-value: 1.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  19 QSSNRVITIVFLALLIDLLGFALILPLFPSILDYYSKTEDgfslslqhgvdwfavmvgmpperkynsvlFGGLIGSIFSV 98
Cdd:COG0738    4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDA-----------------------------QAGLLLFAFFL 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  99 LQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMA 178
Cdd:COG0738   55 GYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLN 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 179 MIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAVAdLIFIFFLLPETLPKEKRVSSVTSgfqaavdllSPL 258
Cdd:COG0738  135 LLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLA-LLFLRSKLPEIEEEEEEAAGSAA---------SLK 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 259 ALFQFSAvtrgrdspseknlqnLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAV---IQGGY 335
Cdd:COG0738  205 SLLKNPR---------------LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIgrfLGGFL 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 336 ARRIKPGneiRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPC-LSAVVSGYGAASQKGrvMGILRSLGA 414
Cdd:COG0738  270 LKRFGPV---RLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTiFSLALDGLGKRTAAA--VSAVLIMGI 344

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 926532221 415 LARALGPILSATVYWLAGAEICFTICSAFFLIPFLLLGSVKQQPKEE 461
Cdd:COG0738  345 VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
90-461 4.01e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 61.44  E-value: 4.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKG-NVSLSTAIIADLH 168
Cdd:COG2223   43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGgSFAVGIALVSKWF 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeaekgEVFFLRSALLALTFAVADLIFIFFLLPETLPKEKRVSsvtsgf 248
Cdd:COG2223  123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLI------AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA------ 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 249 qAAVDLLSPLALFqfsavtrgrdspseKNLQNLkILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITM 328
Cdd:COG2223  191 -AKASLRDQLEAL--------------RDPRFW-LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLG 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 329 AVIQ---GGYARRIKPGNEIRAVkrAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRV 405
Cdd:COG2223  255 ALGRplgGWLSDRIGGRRVLLIV--FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAV 332

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 926532221 406 MGILRSLGALARALGPILSATVYWLAGA-EICFTICSAFFLIPFLLLGSVKQQPKEE 461
Cdd:COG2223  333 YGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRRPRRA 389
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
96-240 1.14e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 56.85  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  96 FSVLQFFSSPLtgavSDCLGRRPVILM-TVMGLIASYALwAASRTFGIFLLSRIIGGISKGNVS-LSTAIIADLHSPKAR 173
Cdd:PRK11102  39 FAIGQLFYGPM----ADSFGRKPVILGgTLVFALAAVAC-ALAQTIDQLIYMRFLHGLAAAAASvVINALMRDMFPKEEF 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 926532221 174 SKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSAllaltFAVADLIFIFFLLPETLPKEKR 240
Cdd:PRK11102 114 SRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLAL-----AAILAAALVFFFIPETLPKERR 175
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 94-398 1.41e-08

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 56.43  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  94 SIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNV-SLSTAIIADLHSPKA 172
Cdd:cd17323   41 SLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTPEE 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 173 RSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLrsaLLALTFAVadLIFIFFLLPETLpkekrVSSVTSGFQAAV 252
Cdd:cd17323  121 RGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWF---LAIISGFC--LILIFLFLPIVL-----LLGLYVGLVYAI 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 253 dllsplalfqfsavtrgrdspseknlqnlkilglayfLYLFLFsgleyTLSFLTHQRFQFSSMQQGKMFFFIGITMaVIQ 332
Cdd:cd17323  191 -------------------------------------LYLFLT-----AFPYVFGEVYGFSPGEVGLMYLPIGIGA-LIG 227

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 333 GGYARRIKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAA----IVIPCLSAVVSGYGA 398
Cdd:cd17323  228 SIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFIGAFLFPIGLFIFGWTIYphihWIVPIIGSAFFGFGL 297
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 90-305 1.95e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 55.59  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKG-NVSLSTAIIADLH 168
Cdd:COG0477   52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGgLMPGALALIAELF 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeaekgEVFFLRSALLALTFAVADLIFIFFLLPETLPKEKRVSSVTSGF 248
Cdd:COG0477  132 PARERGRALGLWGAAIGLGLALGPLLGGLLV------AALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAA 205

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 926532221 249 QAAVDLLSPLALFQFSAVTRGRDSPSEKNLQNLKILGLAYFLYLFLFSGLEYTLSFL 305
Cdd:COG0477  206 LLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAAL 262
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 89-267 3.94e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 55.32  E-value: 3.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  89 GGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVS-LSTAIIADL 167
Cdd:cd17328   36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSpIAPTIIADL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 168 HSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAvadlIFIFFLLPET-----LPKEKRVS 242
Cdd:cd17328  116 FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLA----ILLLLFVREPprgaaEGGVMAKS 191

                        170       180
                 ....*....|....*....|....*....
gi 926532221 243 SVTSGFQAAVDLLSP----LALFQFSAVT 267
Cdd:cd17328  192 TATSFLADLKALAKNpsfiLSTLGFTAVS 220
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 106-247 7.81e-08

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 54.31  E-value: 7.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  106 LTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIG--GISKGNVsLSTAIIADLHSPKARSKGMAMIGVA 183
Cdd:TIGR00710  59 LWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQafGASAGSV-ISQALVRDIYPGEELSRIYSILMPV 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 926532221  184 FSLGFTLGPMIGAYLAMEAEKGEVFFLRSalLALTFAVAdliFIFFLLPETLPKEKRVSSVTSG 247
Cdd:TIGR00710 138 LALAPAVAPLLGGYILVWLSWHAIFAFLS--LAGILLSA---LIFFILPETLPYEARIQISTYF 196
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 108-450 1.13e-07

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 53.76  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 108 GAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGiSKGNVSLSTAIIADLHSPKARSKGMAM----IGVA 183
Cdd:cd17472   53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVMALLADLTREENRTKAMALigasIGIA 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 184 FSLGFTLGPMIGAYLAMEAekgevFFLRSALLALtfavADLIFIFFLLPETLPKEKRVSSVTSGFQAAVdllsplalfqf 263
Cdd:cd17472  132 FAISMVLGPLLAAHLGVSG-----LFLITAILSL----VSLLILLFFVPDPPKIVQISEKEKKKLKKLL----------- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 264 savtrgrdspseKNLQNLKILGLAYFLYLFLFSGLeYTLSFLTHQRFqFSSMQQGKMF---FFIGITMAVIQGGYARRI- 339
Cdd:cd17472  192 ------------KNKRLLRLDFSIFILHFVLMAFF-YILPLLLTQLG-GGKGQLWKVYlpaILIGFILMVPFVIYAEKKg 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 340 KPGNEIRAvkrAIMLLIPAFLLVGWAA-NVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARA 418
Cdd:cd17472  258 KMKQVFVS---SILLIAVGFLLLLFAAtSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSF 334

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 926532221 419 LGPILSATVYWLAGAE----ICFTICSAFFLIPFLL 450
Cdd:cd17472  335 LGGALGGLLWGLLGYSsvflTILILALLWLLVSFLL 370
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 90-451 1.79e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 52.94  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHS 169
Cdd:cd17478   34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 170 PKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeaekgEVFFLRSALLALTF-AVADLIFIFFLLPETLPKEKRVSSVTSGF 248
Cdd:cd17478  114 GGRRGLAMSIFSVGGNLGFALGPLIAAALV------ALFGGLGLLILLIIpGLAVALLLLRLRPLKKPEAKKAAAKSSAR 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 249 QAAVDLLSPLALfqfsavtrgrdspseknlqnlkILGLAYFLYLFLFSGLEYTLSFLTHqrfQFSSMQQGKM----FFFI 324
Cdd:cd17478  188 STLKGVWRALLL----------------------LLIIVFLRSWVLSSLTTFLPFYLVQ---RGYSLVFAGLllslFLFA 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 325 GITMAVIQGGYARRIKPgneiRAVKRAIMLLIPAFLLV-----GWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAA 399
Cdd:cd17478  243 GAIGTLIGGPLSDRFGR----RRVIIASLLLAAPFLLLflltpGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLA 318

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 926532221 400 SqkGRVMGILRSLGAlaralgpILSATVYWLA---GAEICFTICSAFFLIPFLLL 451
Cdd:cd17478  319 S--GLMMGLSFGLGG-------IGAPVLGALAdafGLESVLLILALLPLLGALLA 364
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 87-454 2.46e-07

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 52.65  E-value: 2.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  87 LFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIAD 166
Cdd:cd17391   36 LWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIAS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 167 lHSPKARS-KGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFavadLIFIFFL----LPETLPKEKRV 241
Cdd:cd17391  116 -QTPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAF----LLTLFFVkedfKPVEKKKMVST 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 242 SSVTSGFQAAVDLLSPLALFQFSAVTRGRDSPseknLQNLKILGLAYFLY-LFLFSGLEytlsflthqrfqFSSMQQGKM 320
Cdd:cd17391  191 KEVWNSVPNPSLLISLFVTTFIIQLANQSIEP----ILTLYIRQLMGDASnLAFISGLV------------FSATGVSSL 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 321 FFfigitmAVIQGGYARRIKPGNEIRA--VKRAIMLLIPAFllvgwAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGA 398
Cdd:cd17391  255 LS------APRLGKLGDRIGHHRILLGalLASALLYIPQAF-----VQTPWQLGILRFLLGLATGGLLPAINSLLAKITP 323

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 926532221 399 ASQKGRVMGILRSLGALARALGPILSATVywlAGAeicFTICSAFFLIPFLLLGSV 454
Cdd:cd17391  324 KEVAGRIFGYNQSFQYLGNVAGPLLGSAI---AAH---FGYRAVFVVTALLVLLNA 373
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 90-199 5.01e-07

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 51.41  E-value: 5.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNV-SLSTAIIADLH 168
Cdd:cd17502   33 SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLV 112

                         90       100       110
                 ....*....|....*....|....*....|.
gi 926532221 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLA 199
Cdd:cd17502  113 PPRERGKYQGYIGAVFGIASVAGPLIGGAFT 143
Sugar_tr pfam00083
Sugar (and other) transporter;
82-234 9.44e-07

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 51.12  E-value: 9.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221   82 KYNSVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAAS---RTFGIFLLSRIIGGISKGNVS 158
Cdd:pfam00083  41 LAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGAS 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 926532221  159 -LSTAIIADLHSPKARSKgmamIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAVADLIFIF-FLLPET 234
Cdd:pfam00083 121 vLAPMYISEIAPKKLRGA----LGSLYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGlLFLPES 194
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 91-231 1.21e-06

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 50.35  E-value: 1.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  91 LIGSIFSVlqfFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTF------GIFLLSRIIGGISKGNVSLSTAI- 163
Cdd:cd17386   37 LMGSIPPL---FSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILVLIVYFttvpsvWWFYLSAIPLALFGGFTAFLSASf 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 164 --IADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTfavadLIFIFFLL 231
Cdd:cd17386  114 ayISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIA-----LLYILFFL 178
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 90-235 1.97e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 49.93  E-value: 1.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMT-VMGLIASyALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLH 168
Cdd:cd06179   35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGnLLGVVGS-IVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELV 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 926532221 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKG--EVFFLRSALLALTFAvadLIFIFFLLPETL 235
Cdd:cd06179  114 PNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGwrWIFYINAIFNALALI---LLFFFYHPPPRP 179
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
85-234 4.84e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 48.33  E-value: 4.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  85 SVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRR---PVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLST 161
Cdd:COG2271  214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 926532221 162 AIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeaekgEVFFLRSALLALT-FAVADLIFIFFLLPET 234
Cdd:COG2271  294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL------DATGYQAAFLLLAaLALLAALLALLLLRET 361
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 88-200 7.59e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 47.58  E-value: 7.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  88 FGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLST-AIIAD 166
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGfVLGME 105

                         90       100       110
                 ....*....|....*....|....*....|....
gi 926532221 167 LHSPKARSkgmaMIGVAFSLGFTLGPMIGAYLAM 200
Cdd:cd17317  106 IVGPKYRS----FVGILFGLFWALGYMLLALLAY 135
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 92-450 9.66e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 47.70  E-value: 9.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  92 IGSIFSVLQ---FFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKG-NVSLSTAIIADL 167
Cdd:cd17333   33 VSVIFSSQNagyLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGiLDTGANTFVGAL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 168 hSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeAEKGEVFFLRSALLALTFAVAdLIFIFFLLPETLPKEKRVSSVTSG 247
Cdd:cd17333  113 -FEESSATRLNVLHGFFGLGALIGPLIATSLL--TSELSWSWAYLIIGLIYLLLA-ILILLTLFPELPSARNPQQSVGAF 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 248 FQAAVDLLSPLALFQFSavtrgrdspseknlqnlkilglayfLYLFLFSGLEYTL-----SFLTHQRF-QFSSMQQGKMF 321
Cdd:cd17333  189 SASASRLLRNPSIILGA-------------------------LALFLYVGAETAFsswvpSYLVEKKHvSDGLAGYLLSG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 322 FFIGITMAVIQGGY-ARRIKPGNEIRAVkraIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYgAAS 400
Cdd:cd17333  244 FWVGITIGRLLGGPiSRRIKPHTLLVLS---GSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISN-LPY 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 926532221 401 QKGRVMGILRSLGALARALGPILSATVYWLAGAEICFTICSAFFLIPFLL 450
Cdd:cd17333  320 AKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 105-199 1.82e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.78  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 105 PLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGN-VSLSTAIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17321   49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLWGAV 128

                         90
                 ....*....|....*.
gi 926532221 184 FSLGFTLGPMIGAYLA 199
Cdd:cd17321  129 VGIGAALGPLLGGLLL 144
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 90-235 1.91e-05

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 46.97  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221   90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMT-VMGLIASYALWAASRtFGIFLLSRIIGGISKGNVSLSTAIIADLH 168
Cdd:pfam06609  81 GLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIAThIIGLVGAIVGCTANK-FNTLLAAMTLLGVAAGPAGASPLFIGELM 159

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 926532221  169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFlrsaLLALTFAVADLIFIFFLLPETL 235
Cdd:pfam06609 160 SNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFY----IYIIMSAIAVLLIIIWYHPPSF 222
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 103-225 2.66e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 46.03  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 103 SSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGV 182
Cdd:cd17504   47 STPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSA 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 926532221 183 AFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAVADLI 225
Cdd:cd17504  127 TFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI 169
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
351-451 3.19e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.74  E-value: 3.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 351 AIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPILSATVYWL 430
Cdd:COG2814   81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                         90       100
                 ....*....|....*....|.
gi 926532221 431 AGAEICFTICSAFFLIPFLLL 451
Cdd:COG2814  161 FGWRWVFLVNAVLALLALLLL 181
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
90-432 5.39e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 45.25  E-value: 5.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGG--ISKGNVSLSTAIIADL 167
Cdd:COG2807   56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGagIAVGNVLLPGLIKRWF 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 168 hsPKARSKGMAMIGVAFSLGFTLGPMIGAYLAmeaekgEVFFLRSALLAltFAVADLIFIFFLLPETLPKEKRVSSVTSG 247
Cdd:COG2807  136 --PDRVGLMTGLYTAAMGLGAALAAGLTVPLA------AALGWRGALAV--WALLALLALLLWLPLLRRRPAAAAAAPAA 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 248 FQAAVDLLSPLALfqfsavtrgrdspseknlqnlkILGLAYFLYLFLFSGLeytLSFLTH--QRFQFSSMQQGKMFF--- 322
Cdd:COG2807  206 ASLRSLWRSPLAW----------------------LLTLFFGLQSLLYYAV---VAWLPPilRDAGLSAATAGLLLSlfq 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 323 FIGITMAVIQGGYARRIKPgneiravKRAIMLLIPAFLLVG----WAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGY-G 397
Cdd:COG2807  261 LAGIPGSLLVPLLADRLGD-------RRPLLLLLGLLGLAGllglLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRaR 333

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 926532221 398 AASQKGRVMGILRSLGALARALGPILSATVYWLAG 432
Cdd:COG2807  334 TPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG 368
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
105-260 6.14e-05

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 45.01  E-value: 6.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 105 PLTGAVSDCLGRRPVILM-TVMGLIASYaLWAASRTFGIFLLSRIIGGISKGNVSLST-AIIADLHSPKARSKGMAMIGV 182
Cdd:PRK10473  56 LFAGKIADRSGRKPVAIPgAALFIIASL-LCSLAETSSLFLAGRFLQGIGAGCCYVVAfAILRDTLDDRRRAKVLSLLNG 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 926532221 183 AFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFavadlIFIFFLLPETLPKEKRVSSvTSGFQAAVDLLSPLAL 260
Cdd:PRK10473 135 ITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVL-----LLSLFILKETRPARAPAAS-SKPRENSESLLNRFFL 206
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 90-201 6.85e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 45.01  E-value: 6.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221   90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGI-SKGNVSLSTAIIADLH 168
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMgIGGIWVQAVVLNTEFL 209

                          90       100       110
                  ....*....|....*....|....*....|...
gi 926532221  169 SPKARSKGMAMIGVAFSLGFTLGPMIgAYLAME 201
Cdd:TIGR00898 210 PKKQRAIVGTLIQVFFSLGLVLLPLV-AYFIPD 241
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
87-240 7.36e-05

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 44.91  E-value: 7.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  87 LFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIAD 166
Cdd:PRK09874  54 MWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIAT 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 926532221 167 lHSPKARSK-GMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFavadLIFIFFLLPETLPKEKR 240
Cdd:PRK09874 134 -QVPRNKSGwALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCF----LVTLFCIRENFQPVSKK 203
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 102-239 7.88e-05

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 44.80  E-value: 7.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 102 FSSPLTGAVSDCLGRRPVILMTVMGLI--ASYALWAASRTF--GIFLLSRIIGGISkGNVSL----STAIIADLHSPKAR 173
Cdd:cd17449   80 FSVTLLGPWSDSVGRRPVLILPSLGLAlqAAVYLLVMYLQLhvAYFLIGRILSGLL-GDFNGilagCFAYVADVSDRRSR 158

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 926532221 174 SKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLrsaLLALTFAVAdlIFIFFLLPETLPKEK 239
Cdd:cd17449  159 TFRVAVLEACLGLAGMLASIIGGQWRKAQGYINPFWL---VLALNLAAA--LYAAFCVGESVKEPK 219
emrD PRK11652
multidrug transporter EmrD;
98-249 9.07e-05

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 44.51  E-value: 9.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  98 VLQFFSSPLtgavSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNV-SLSTAIIADLHSPKA--RS 174
Cdd:PRK11652  58 LSQLFYGPL----SDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGgVMARTLPRDLYEGTQlrHA 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 926532221 175 KGMAMIGVAFSLgfTLGPMIGAYLAmeaekgEVFFLRSA-LLALTFAVADLIFIFFLLPETLPKEKRVSSVTSGFQ 249
Cdd:PRK11652 134 NSLLNMGILVSP--LLAPLIGGLLT------TLFGWRACyLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYR 201
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 105-225 9.38e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 44.49  E-value: 9.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 105 PLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGN-VSLSTAIIADLHSPKARSKGMAMIGVA 183
Cdd:cd17503   49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLV 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 926532221 184 FSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAVADLI 225
Cdd:cd17503  129 ILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL 170
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 85-236 9.60e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.49  E-value: 9.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  85 SVLFGGLIGSIFSvlqffsspltGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAI- 163
Cdd:cd17315   42 SLLLGAAIGSLFG----------GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLy 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 926532221 164 IADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKG-EVFFLRSALLALTFAVAdlifiFFLLPETLP 236
Cdd:cd17315  112 ISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWwRLMFALAAVPALLQLLL-----MFFLPESRA 180
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 105-240 1.07e-04

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 44.68  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  105 PLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGN-VSLSTAIIADLHSPKARSKGMAMIGVA 183
Cdd:TIGR00711  55 PLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPlIPLSFSTLLNIYPPEKRGRAMAIWGLT 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 926532221  184 FSLGFTLGPMIGAYLAMEAEKGEVFFLRsallaLTFAVADLIFIFFLLPETLPKEKR 240
Cdd:TIGR00711 135 VLVAPALGPTLGGWIIENYHWRWIFLIN-----VPIGIIVVVVAFFILPRDKPAASE 186
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
85-198 1.13e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.10  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  85 SVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWA-ASRTFGIFLLSRIIGGISKGNVSLST-A 162
Cdd:COG2223  239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAlALGSLWLFLVLFLLLGLALGGGNGAVfA 318

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 926532221 163 IIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYL 198
Cdd:COG2223  319 LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
MFS_1 pfam07690
Major Facilitator Superfamily;
284-451 1.26e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  284 LGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFFFIGITMAVIQGGYARRIKPGNEIRAVKRAIMLLIPAFLLVG 363
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  364 WAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPILSATVYWLAGAEICFTICSAF 443
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160


                  ....*...
gi 926532221  444 FLIPFLLL 451
Cdd:pfam07690 161 SLLAAVLL 168
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
90-451 1.26e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.12  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQF---FSSPLTGAVSDCLG-----RRPVILMTVMGLIASYAL------WAASRTFGIFLLSRIIGGISKG 155
Cdd:COG2211   46 ALVGLILLVARLwdaITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLlftapdLSPTGKLIYALVTYLLLGLAYT 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 156 NVSLS-TAIIADL-HSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVF-FLRSALLALTFAVADLIFIFFLLP 232
Cdd:COG2211  126 LVNIPySALGAELtPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALgYRLTALIFAVLGLLAFLLTFFGTK 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 233 ETLPKEKRVSSVTSGFQAAVdllsplalfqfsavtrgrdspseKNLQnLKILGLAYFLYLFLFSGLEYTLSFLTHQRFQF 312
Cdd:COG2211  206 ERPVPEEEKVSLKESLKALL-----------------------KNRP-FLLLLLAYLLFFLALALVAALLLYYFKYVLGL 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 313 SSMQQGKMFFFIGITMAVIQ---GGYARRIKPgneiRAVKRAIMLLIPAFLLVGW---AANVTMLSVGLLLYSFAAAIVI 386
Cdd:COG2211  262 SAALVGLLLALYFLAALLGAplwPRLAKRFGK----KKAFIIGLLLAALGLLLLFflgPGNLWLLLVLAALAGIGLGAIL 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 387 PCLSAVVSG---YGAASQKGRVMGILRSLGALAR----ALGPILSATVYWLAG--------AEICFTICSAFFLIPFLLL 451
Cdd:COG2211  338 VLPWAMLADvvdYDEWKTGRRREGLYFGIFTFAIklgqALAGALAGLLLALFGyvagaaqsPSALTGIRLLFFLLPAVLL 417
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 75-234 1.87e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 43.78  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  75 VGMPPERKYNSVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMG-LIASYALWAASRTFGIFLLSRIIGGIS 153
Cdd:cd17356   33 FADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIyIIGAIIQVAAIGKWYQLIVGRIIAGLG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 154 KGNVSLSTAIIADLHSPKARsKGmaMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAVADLIFIF-FLLP 232
Cdd:cd17356  113 VGFASVLVPVYQSEVAPKHI-RG--TLVSLYQLAITIGILVAYCINYGTHKLDGSAQWRIPLGLQIVWGLLLLIGmFFLP 189


                 ..
gi 926532221 233 ET 234
Cdd:cd17356  190 ES 191
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 90-234 2.98e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 43.02  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPV-----ILMTVMGLIASYALWAASrtFGIFLLSRIIGGISKGnvsLSTAII 164
Cdd:cd17357   52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGllisnALLVVSSLLMFLSKSAKS--PELLIFGRFLVGIACG---LSTGFV 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 165 ADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAVADLIFIFFLLPET 234
Cdd:cd17357  127 PMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPES 196
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 90-423 3.22e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 42.56  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISK-GNVSLSTAIIADLH 168
Cdd:cd17319   41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEaGFFPGAIKALAEWF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 169 SPKARSKGMAMIGVAFSLGFTLGPMIGAYLaMEAEKGEVFFLRSALLALTFAVadliFIFFLLPETLpkekrvssvtsgf 248
Cdd:cd17319  121 PARERGRATGLFNSGAPLGAAIGPPLSGWL-LLLFGWRWAFIIEGLLGLLLAV----LWWFYLRQVW------------- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 249 qaavdllsplalfqfsavtrgrdspseknlqnlkILGLAYFLYLFLFSGLEYTLSFLTHQRFQFSSMQQGKMFF--FIGI 326
Cdd:cd17319  183 ----------------------------------GLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAipFLAG 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 327 TMAVIQGGY-ARRIKPGNEIRAVKRAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRV 405
Cdd:cd17319  229 AIGMILGGRlSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATA 308

                        330
                 ....*....|....*...
gi 926532221 406 MGILRSLGALARALGPIL 423
Cdd:cd17319  309 GGLINSGGNLGGFVAPLL 326
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 85-225 3.24e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 42.98  E-value: 3.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  85 SVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGR-RPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKG-NVSLSTA 162
Cdd:cd17353  247 DAGIAALAVSILSIFNGGGRPFWGWLSDKIGRkNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGgGFALFPA 326

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 926532221 163 IIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAVADLI 225
Cdd:cd17353  327 LTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 85-175 3.25e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 42.94  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  85 SVLFGGLIGSIFSvlqffsspltGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVS-LSTAI 163
Cdd:cd17359   44 SALLGAAIGALFA----------GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASaLVPMY 113

                         90
                 ....*....|..
gi 926532221 164 IADLHSPKARSK 175
Cdd:cd17359  114 IAEVAPAEIRGR 125
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 85-451 6.35e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 6.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  85 SVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRR-PVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKG-NVSLSTA 162
Cdd:cd17370   32 SAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGiRTPPRDA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 163 IIADLHSPKARSKGMamiGVAFSLGfTLGPMIGAYLAMeaekgevfflrsALLALTFAVADLIFIFFLLPetlpkekrvs 242
Cdd:cd17370  112 LLADATPPSGRGKAF---GLHRALD-TLGAVLGPLLAA------------LLLYLLGGNYRTIFLLAAIP---------- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 243 svtsgfqaAVDLLSPLALFQFsAVTRGRDSPSEKNLQNLKILGLAYFLYLFLFSglEYTLSFLTHQRFQFSSMQQGKMFF 322
Cdd:cd17370  166 --------ALLALLILLFVVK-EYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVA--LFALGNFSFAFLILRAQELGLSAA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 323 FIGITMAVIQGGYA----------RRIKPGNEIRAvkrAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAV 392
Cdd:cd17370  235 LIPLLYALFNLVYAlaaypagrlsDRIGRKKLLIL---GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAA 311

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 926532221 393 VSGYGAASQKGRVMGILRSLGALARALGPILSATVYWLAGAEICFTICSAFFLIPFLLL 451
Cdd:cd17370  312 VADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 358-458 7.00e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 7.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 358 AFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPILSATVYWLAGAEICF 437
Cdd:cd17489   74 ATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLF 153

                         90       100
                 ....*....|....*....|.
gi 926532221 438 TICSAFFLIPFLLLGSVKQQP 458
Cdd:cd17489  154 IVAAVLALLALLLVFLVKDPP 174
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 82-229 7.10e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.77  E-value: 7.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  82 KYNSVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLST 161
Cdd:cd17478  225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV 304

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 926532221 162 AIIADLhspKARSKGMA---MIGVAFSLGFTLGPMIGAYlameaekGEVFFLRSALLALTFAVADLIFIFF 229
Cdd:cd17478  305 VLAQEL---LPGNVGLAsglMMGLSFGLGGIGAPVLGAL-------ADAFGLESVLLILALLPLLGALLAF 365
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 108-222 7.14e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.78  E-value: 7.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 108 GAVSDCLGRRPVILMT--VMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAIIADLHSPKARSKGMAMIGVAFS 185
Cdd:cd17477  244 GWLADRFDRRRVLLGCalLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYG 323

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 926532221 186 LGFTLGPMIGAyLAMEAEKGEVFFLRSALLALTFAVA 222
Cdd:cd17477  324 LGSVIGPLLAG-ALMDAFGPHGLFLFLAAVALLFLLF 359
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 94-237 8.76e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 41.51  E-value: 8.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  94 SIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNVSLSTAI-IADLHSPKA 172
Cdd:cd17374   42 SIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLIlGTEWTTPRH 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 926532221 173 RskgmAMIGVAFSLGFTLGPMIGAYLAmeaekgevFFLRSALLaLTFAVADLIFIFFLLPETLPK 237
Cdd:cd17374  122 R----ALAITLTSCFFSIGQMLLAGLA--------YAIRDWRL-LQLVVSVPFFLFFLYSWWLPK 173
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 83-198 9.79e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.38  E-value: 9.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  83 YNSVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRT-FGIFLLSRIIGGISKGNVSLST 161
Cdd:cd17324  230 GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSpLLLLVGLVLWGLGFFAAHSALQ 309

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 926532221 162 AIIADLhSPKARSKGMAMIGVAFSLGFTLGPMIGAYL 198
Cdd:cd17324  310 TRVLRL-APEARGLASSLYLAAYNLGGALGAALGGLV 345
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 91-198 1.19e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 40.80  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  91 LIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGI-SKGNVSLSTAIIADLHS 169
Cdd:cd17379   37 LFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLfGKGGWMTGYVLVTEFVG 116

                         90       100
                 ....*....|....*....|....*....
gi 926532221 170 PKARSKGMAMIGVAFSLGFTLGPMIgAYL 198
Cdd:cd17379  117 SKYRRTVGIVYQMFFTLGLLILPGI-AYF 144
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 350-460 1.88e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 40.29  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 350 RAIMLLIPAFLLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPILSATVYW 429
Cdd:cd06173   74 RALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVA 153

                         90       100       110
                 ....*....|....*....|....*....|.
gi 926532221 430 LAGAEICFTICSAFFLIPFLLLGSVKQQPKE 460
Cdd:cd06173  154 LLGPGGAFAINALSFLLSALLLLFIRRPPPA 184
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
283-450 2.39e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.85  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 283 ILGLAYFLYLFLFSGLEYTLSFLThQRFQFSSMQQGKMFFFIGITMAVIQ---GGYARRIKPGneiRAVKRAIMLLIPAF 359
Cdd:COG2271   14 LLFLAYFLNYLDRSNLSVAAPPLQ-ADLGLSAAQLGLLASAFFLGYALGQipaGLLADRFGRR---RVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 360 LLVGWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPILSATVYWLAGAEICFTI 439
Cdd:COG2271   90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169

                        170
                 ....*....|.
gi 926532221 440 CSAFFLIPFLL 450
Cdd:COG2271  170 LGLPGLLLALL 180
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 87-200 2.79e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.88  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  87 LFGGLIGSIFSvlqffsspltGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKGNV-SLSTAIIA 165
Cdd:cd17365   44 LFGMAIGALLA----------GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAmPNAITLVS 113

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 926532221 166 DLHSPKARSkgmAMIGVAFSlGFTLGPMIGAYLAM 200
Cdd:cd17365  114 EYAPARRRS---LAVTLMFC-GYPLGAALGGFLAA 144
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 71-226 4.30e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 39.09  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  71 FAVMVGMP---PERKYNSVLFGGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSR 147
Cdd:cd17473  214 YVIPIQLPfllQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGA 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 148 IIGGISKG-NVSLSTAIIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFFLRSALLALTFAVADLIF 226
Cdd:cd17473  294 ILAGLGFGlLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 90-233 5.06e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.07  E-value: 5.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  90 GLIGSIFSVLQFFSSPLTGAVSDCLG-RRPVILMTVMGLIASYALWAASRTF------GIFLLSriIGGISKGNVSLSTA 162
Cdd:cd17471   35 GIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYwvlllvGVVLLS--LGAAAFPQLFALAR 112

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 926532221 163 IIADLHSPKARSKGMAMIGVAFSLGFTLGPMIGAYLAMEAEKGEVFflrsaLLALTFAVADLIFIFFLLPE 233
Cdd:cd17471  113 EYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLF-----LLAALLYLVVALLVLFLLPS 178
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
21-190 6.59e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.42  E-value: 6.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  21 SNRVITIVFLALLIDLLGFALILPLFPSILdyysktEDGFSLSLQHgvdwfavmvgmpperkynsvlfGGLIGSIFSVLQ 100
Cdd:COG2814  205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYL------QEVLGLSASA----------------------AGLLLALFGLGG 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 101 FFSSPLTGAVSDCLGRRPVILMTVMGLIASYALWAASRTFGIFLLSRIIGGISKG-NVSLSTAIIADLHSPKARSKGMAM 179
Cdd:COG2814  257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGlLFPLLQALVAELAPPEARGRASGL 336

                        170
                 ....*....|.
gi 926532221 180 IGVAFSLGFTL 190
Cdd:COG2814  337 YNSAFFLGGPL 347
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 70-461 6.70e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 38.60  E-value: 6.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221  70 WFAVMVGMPPERKYNSVLfgGLIGSIFSVLQFFSSPLTGAVSDCLGRRPVILM--TVMGLIASYALW-AASRTFGIFLLS 146
Cdd:COG2270   37 YFTSVAALGDPAAATALW--GYALAIAGLLVALLAPVLGAIADRSGRKKPFLAffTLLGVLATAALFfVAPGGLWLGLLL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 147 RIIGGISKgNVSLST--AIIADLHSPKAR----SKGMAM--IGVAFSLGFTLGPMIGAYLAMEAEKGEVF---FLRSALL 215
Cdd:COG2270  115 FVLANIGF-EGSLVFynAFLPDIATPEEIgrvsGLGWALgyLGGVLLLLINLALFLKPEAFGLPDAGEAVrisFLLTALW 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 216 ALTFAvadlIFIFFLLPETLPKEK--RVSSVTSGFQAAVDLLSPLalfqfsavtrgrdspseKNLQNLKILGLAYFLY-- 291
Cdd:COG2270  194 WLLFA----LPLFLFLPERPRPGPapPRGAVRAGFRELRRTLREL-----------------RRYRDLLRFLLAYFFYrd 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 292 ----LFLFSGLeytlsfLTHQRFQFSSMQQGKMFF---FIGITMAVIQGGYARRIKPgneiravKRAIMLlipafllvgw 364
Cdd:COG2270  253 gvqtVIAFAGI------YAAGVLGFSTTELIVFGLlvqIVAALGALLFGRLDDRIGP-------KRVILV---------- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 365 aANVTMLSVGLLLYSFAAA----IVIPCLSAVVSGYGAAS-----------QKGRVMGILRSLGALARALGPILSATVYW 429
Cdd:COG2270  310 -SLVIWIVVCLAAYFLTTAlafwILGLLIGLVMGGIQALSrsllarlippgREAEFFGLYALSGKAASFLGPLLFGLVTQ 388

                        410       420       430
                 ....*....|....*....|....*....|...
gi 926532221 430 LAGA-EICFTICSAFFLIPFLLLGSVKQQPKEE 461
Cdd:COG2270  389 LTGSqRLGILSLIVFFVIGLVLLLRVKVPRGRA 421
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
289-451 8.89e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.32  E-value: 8.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 289 FLYLFLFSGLEYTLSFLTH---QRFQFSSMQQG---KMFFFIGITMAVIQGGYARRIKPGneiRAVKRAIMLLIPAFLLV 362
Cdd:COG2223   11 TLAFFLAFGVWYLWSVLAPplaEEFGLSAAQLGllfAIPVLVGALLRIPLGFLVDRFGPR---RVLLIGLLLLGIGLLLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926532221 363 GWAANVTMLSVGLLLYSFAAAIVIPCLSAVVSGYGAASQKGRVMGILRSLGALARALGPILSATVYWLAGAEICFTICSA 442
Cdd:COG2223   88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167


                 ....*....
gi 926532221 443 FFLIPFLLL 451
Cdd:COG2223  168 LLLVVAVLA 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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