|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
1-316 |
0e+00 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 635.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVVIS 80
Cdd:cd19143 1 MEYRRLGRSGLKVSALSFGSWVTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELGWPRSDYVVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLFWGGQG--PNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQ 158
Cdd:cd19143 81 TKIFWGGGGppPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGTSEWSAQQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 159 ITEAWAVANRLDLVGPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGnIPADSRFALDNYKNL 238
Cdd:cd19143 161 IEEAHEIADRLGLIPPVMEQPQYNLFHRERVEVEYAPLYEKYGLGTTTWSPLASGLLTGKYNNG-IPEGSRLALPGYEWL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 239 ANRS--LVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPLLTPEVVDRIEAV 316
Cdd:cd19143 240 KDRKeeLGQEKIEKVRKLKPIAEELGCSLAQLAIAWCLKNPNVSTVITGATKVEQLEENLKALEVLPKLTPEVMEKIEAI 319
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
10-309 |
8.03e-160 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 448.19 E-value: 8.03e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRdlGWRRSDVVISTKLFWG-GQ 88
Cdd:cd19074 1 GLKVSELSLGTWLTFGGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALK--GWPRESYVISTKVFWPtGP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 89 GPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANR 168
Cdd:cd19074 79 GPNDRGLSRKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDLARQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 169 LDLVGPIVEQPEYNLFSRHKVEsEFLPLYSTYGIGLTTWSPLASGVLTGKYTKG-NIPADSRFALDNYKNLANRSLVDDT 247
Cdd:cd19074 159 FGLIPPVVEQPQYNMLWREIEE-EVIPLCEKNGIGLVVWSPLAQGLLTGKYRDGiPPPSRSRATDEDNRDKKRRLLTDEN 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 925114528 248 LRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDviPLLTPEV 309
Cdd:cd19074 238 LEKVKKLKPIADELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASG--VKLSPEV 297
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
3-309 |
3.72e-137 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 391.42 E-value: 3.72e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 3 YKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVVISTK 82
Cdd:cd19141 2 YRNLGKSGLRVSCLGLGTWVTFGSQISDEVAEELVTLAYENGINLFDTAEVYAAGKAEIVLGKILKKKGWRRSSYVITTK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 83 LFWGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEA 162
Cdd:cd19141 82 IFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRWSAMEIMEA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 163 WAVANRLDLVGPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGnIPADSRFALDNYKNLANRS 242
Cdd:cd19141 162 YSVARQFNLIPPIVEQAEYHLFQREKVEMQLPELFHKIGVGAMTWSPLACGILSGKYDDG-VPEYSRASLKGYQWLKEKI 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 243 LVDDTLR---KVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPLLTPEV 309
Cdd:cd19141 241 LSEEGRRqqaKLKELQIIADRLGCTLPQLAIAWCLKNEGVSSVLLGASSTEQLYENLQAIQVLPKLTPNI 310
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
1-321 |
5.76e-130 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 373.55 E-value: 5.76e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVVIS 80
Cdd:cd19160 3 MKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVVT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLFWGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQIT 160
Cdd:cd19160 83 TKIYWGGQAETERGLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTSRWSAMEIM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 161 EAWAVANRLDLVGPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTkGNIPADSRFALDNYKNLAN 240
Cdd:cd19160 163 EAYSVARQFNLIPPVCEQAEYHLFQREKVEMQLPELYHKIGVGSVTWSPLACGLITGKYD-GRVPDTCRAAVKGYQWLKE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 241 RSLVDDTLR---KVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPLLTPEVVDRIEAVV 317
Cdd:cd19160 242 KVQSEEGKKqqaKVKELHPIADRLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIENLGSIQVLSQLTPQTVMEIDALL 321
|
....
gi 925114528 318 QSKP 321
Cdd:cd19160 322 GNKP 325
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
1-321 |
4.54e-129 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 371.30 E-value: 4.54e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVVIS 80
Cdd:cd19159 1 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLFWGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQIT 160
Cdd:cd19159 81 TKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 161 EAWAVANRLDLVGPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGnIPADSRFALDNYKNLAN 240
Cdd:cd19159 161 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNG-VPESSRASLKCYQWLKE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 241 RSLVDDTLRKVNGLK---PIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPLLTPEVVDRIEAVV 317
Cdd:cd19159 240 RIVSEEGRKQQNKLKdlsPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNIL 319
|
....
gi 925114528 318 QSKP 321
Cdd:cd19159 320 RNKP 323
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
1-321 |
3.16e-126 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 363.73 E-value: 3.16e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAWvTFGN---QLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgWRRSDV 77
Cdd:COG0667 1 MEYRRLGRSGLKVSRLGLGTM-TFGGpwgGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKG--RPRDDV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 78 VISTKLFW-GGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSA 156
Cdd:COG0667 78 VIATKVGRrMGPGPNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYSA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 157 QQITEAWAVANrlDLVGPIVEQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGN-IPADSRFALdny 235
Cdd:COG0667 158 EQLRRALAIAE--GLPPIVAVQNEYSLLDR-SAEEELLPAARELGVGVLAYSPLAGGLLTGKYRRGAtFPEGDRAAT--- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 236 kNLANRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIplLTPEVVDRIEA 315
Cdd:COG0667 232 -NFVQGYLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLE--LSAEDLAALDA 308
|
....*.
gi 925114528 316 VVQSKP 321
Cdd:COG0667 309 ALAAVP 314
|
|
| Kv_beta |
TIGR01293 |
voltage-dependent potassium channel beta subunit, animal; This model describes the conserved ... |
3-317 |
2.23e-123 |
|
voltage-dependent potassium channel beta subunit, animal; This model describes the conserved core region of the beta subunit of voltage-gated potassium (Kv) channels in animals. Amino-terminal regions differ substantially, in part by alternative splicing, and are not included in the model. Four beta subunits form a complex with four alpha subunit cytoplasmic (T1) regions, and the structure of the complex is solved. The beta subunit belongs to a family of NAD(P)H-dependent aldo-keto reductases, binds NADPH, and couples voltage-gated channel activity to the redox potential of the cell. Plant beta subunits and their closely related bacterial homologs (in Deinococcus radiudurans, Xylella fastidiosa, etc.) appear more closely related to each other than to animal forms. However, the bacterial species lack convincing counterparts the Kv alpha subunit and the Kv beta homolog may serve as an enzyme. Cutoffs are set for this model such that yeast and plant forms and bacterial close homologs score between trusted and noise cutoffs.
Pssm-ID: 213602 [Multi-domain] Cd Length: 317 Bit Score: 356.55 E-value: 2.23e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 3 YKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVVISTK 82
Cdd:TIGR01293 1 YRNLGKSGLRVSCLGLGTWVTFGGQISDEMAEQLLTLAYENGINLFDTAEVYAAGKAEVVLGNILKKKGWRRSSYVITTK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 83 LFWGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEA 162
Cdd:TIGR01293 81 IFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEETVRAMTYVINQGMAMYWGTSRWSSMEIMEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 163 WAVANRLDLVGPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYtKGNIPADSRFALDNYKNLANRS 242
Cdd:TIGR01293 161 YSVARQFNLIPPICEQAEYHMFQREKVEVQLPELYHKIGVGAMTWSPLACGLVSGKY-DSGIPPYSRATLKGYQWLKDKI 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 925114528 243 LVDDTLR---KVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPLLTPEVVDRIEAVV 317
Cdd:TIGR01293 240 LSEEGRRqqaRLKDLQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASSAEQLMENLGSLQVLPKLSSSIIHEIDSIL 317
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
1-321 |
2.58e-116 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 338.98 E-value: 2.58e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVVIS 80
Cdd:cd19158 1 QFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLFWGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQIT 160
Cdd:cd19158 81 TKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 161 EAWAVANRLDLVGPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGnIPADSRFALDNYKNLAN 240
Cdd:cd19158 161 EAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSG-IPPYSRASLKGYQWLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 241 RSLVDDTLR---KVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPLLTPEVVDRIEAVV 317
Cdd:cd19158 240 KILSEEGRRqqaKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSIL 319
|
....
gi 925114528 318 QSKP 321
Cdd:cd19158 320 GNKP 323
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
1-317 |
8.48e-113 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 329.53 E-value: 8.48e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAwVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgwRRSDVVIS 80
Cdd:cd19087 1 MEYRTLGRTGLKVSRLCLGT-MNFGGRTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAG---RRDDIVLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLFWG-GQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQI 159
Cdd:cd19087 77 TKVFGPmGDDPNDRGLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSNFAAWQI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 160 TEAWAVANRLDLVGPIVEQPEYNLFSRHkVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADSRFALDNYKNLa 239
Cdd:cd19087 157 AKAQGIAARRGLLRFVSEQPMYNLLKRQ-AELEILPAARAYGLGVIPYSPLAGGLLTGKYGKGKRPESGRLVERARYQA- 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 925114528 240 nRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIplLTPEVVDRIEAVV 317
Cdd:cd19087 235 -RYGLEEYRDIAERFEALAAEAGLTPASLALAWVLSHPAVTSPIIGPRTLEQLEDSLAALEIT--LTPELLAEIDELF 309
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
1-321 |
5.90e-109 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 320.18 E-value: 5.90e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVVIS 80
Cdd:cd19142 1 LKYRNLGKSGLRVSNVGLGTWSTFSTAISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILKKKGWKRSSYIVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLFWGGqGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQIT 160
Cdd:cd19142 81 TKIYWSY-GSEERGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSPVEIM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 161 EAWAVANRLDLVGPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTG-KYTKGNIPADSRFALDNYKNLA 239
Cdd:cd19142 160 EAFSIARQFNCPTPICEQSEYHMFCREKMELYMPELYNKVGVGLITWSPLSLGLDPGiSEETRRLVTKLSFKSSKYKVGS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 240 NRSLVDDTLRKVNG----LKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPLLTPEVVDRIEA 315
Cdd:cd19142 240 DGNGIHEETRRASHklreLSLIAERLGCDLTQLLIAWSLKNENVQCVLIGASSLEQLYSQLNSLQLLPKLNSAVMEELER 319
|
....*.
gi 925114528 316 VVQSKP 321
Cdd:cd19142 320 ILDNKP 325
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
1-316 |
3.98e-101 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 299.91 E-value: 3.98e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAwVTFG---------NQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlg 71
Cdd:cd19091 1 MEYRTLGRSGLKVSELALGT-MTFGggggffgawGGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKG-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 72 wRRSDVVISTKL-FWGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWG 150
Cdd:cd19091 78 -RRDDVLIATKVrGRMGEGPNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVRYIG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 151 TSEWSAQQITEAWAVANRLDLVGPIVEQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGN-IPADSR 229
Cdd:cd19091 157 VSNFSAWQIMKALGISERRGLARFVALQAYYSLLGR-DLEHELMPLALDQGVGLLVWSPLAGGLLSGKYRRGQpAPEGSR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 230 FALDNYKNLA-NRSLVDDTlrkVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIplLTPE 308
Cdd:cd19091 236 LRRTGFDFPPvDRERGYDV---VDALREIAKETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGAAGLS--LTPE 310
|
....*...
gi 925114528 309 VVDRIEAV 316
Cdd:cd19091 311 EIARLDKV 318
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
2-314 |
2.42e-98 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 292.57 E-value: 2.42e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 2 QYKNLGRSGLRVSQLSYGAWvTFGNQ------LDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGwRRS 75
Cdd:cd19079 1 EYVRLGNSGLKVSRLCLGCM-SFGDPkwrpwvLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFA-PRD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 76 DVVISTKLFW-GGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEW 154
Cdd:cd19079 79 EVVIATKVYFpMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSM 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 155 SAQQITEAWAVANRLDLVGPIVEQPEYNLFSRHKvESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNipaDSRFALDN 234
Cdd:cd19079 159 YAWQFAKALHLAEKNGWTKFVSMQNHYNLLYREE-EREMIPLCEEEGIGVIPWSPLARGRLARPWGDTT---ERRRSTTD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 235 YKNLANRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIplLTPEVVDRIE 314
Cdd:cd19079 235 TAKLKYDYFTEADKEIVDRVEEVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIK--LSEEEIKYLE 312
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
6-313 |
1.00e-87 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 265.62 E-value: 1.00e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 6 LGRSGLRVSQLSYGAWVtFGNQLDVKEAKALLQACRDAGVNFFDNAEVY-------ANGRAEEIMGQAIRDLGwRRSDVV 78
Cdd:cd19081 2 LGRTGLSVSPLCLGTMV-FGWTADEETSFALLDAFVDAGGNFIDTADVYsawvpgnAGGESETIIGRWLKSRG-KRDRVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 79 ISTKLFWGgQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQ 158
Cdd:cd19081 80 IATKVGFP-MGPNGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGASNYSAWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 159 ITEAWAVANRLDLVGPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADSRFALDNYKNL 238
Cdd:cd19081 159 LQEALELSRQHGLPRYVSLQPEYNLVDRESFEGELLPLCREEGIGVIPYSPLAGGFLTGKYRSEADLPGSTRRGEAAKRY 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 925114528 239 ANrslvDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIplLTPEVVDRI 313
Cdd:cd19081 239 LN----ERGLRILDALDEVAAEHGATPAQVALAWLLARPGVTAPIAGARTVEQLEDLLAAAGLR--LTDEEVARL 307
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
3-304 |
7.83e-86 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 260.65 E-value: 7.83e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 3 YKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVY--ANGRAEEIMGQAI-RDLGWRRSDVVI 79
Cdd:cd19089 1 YRRCGRSGLHLPAISLGLWHNFGDYTSPEEARELLRTAFDLGITHFDLANNYgpPPGSAEENFGRILkRDLRPYRDELVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 80 STKLFWG-GQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQ 158
Cdd:cd19089 81 STKAGYGmWPGPYGDGGSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGISNYPGAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 159 ITEAWAVANRLDlVGPIVEQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADSRFAldNYKNL 238
Cdd:cd19089 161 ARRAIALLRELG-VPLIIHQPRYSLLDR-WAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKYLNGIPPDSRRAA--ESKFL 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 925114528 239 ANRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPL 304
Cdd:cd19089 237 TEEALTPEKLEQLRKLNKIAAKRGQSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALKNLDF 302
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
10-314 |
1.51e-85 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 259.38 E-value: 1.51e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWV---TFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgwRRSDVVISTK--LF 84
Cdd:cd19084 1 DLKVSRIGLGTWAiggTWWGEVDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKG---RRDDVVIATKcgLR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 85 WGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAwa 164
Cdd:cd19084 78 WDGGKGVTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEA-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 165 vanrLDLVGPIVEQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNI--PADSRFALDNYKnlanRS 242
Cdd:cd19084 156 ----RKYGPIVSLQPPYSMLER-EIEEELLPYCRENGIGVLPYGPLAQGLLTGKYKKEPTfpPDDRRSRFPFFR----GE 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 925114528 243 LVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIplLTPEVVDRIE 314
Cdd:cd19084 227 NFEKNLEIVDKLKEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWE--LTEEELKEID 296
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
6-314 |
4.33e-78 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 240.97 E-value: 4.33e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 6 LGRSGLRVSQLSYGAwVTFGNQ----LDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgwRRSDVVIST 81
Cdd:cd19080 3 LGRSGLRVSPLALGT-MTFGTEwgwgADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAG---NRDRIVLAT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 82 KLFWG--GQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQI 159
Cdd:cd19080 79 KYTMNrrPGDPNAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISDTPAWVV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 160 TEAWAVANRLDLVGPIVEQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADSR----FALDNY 235
Cdd:cd19080 159 ARANTLAELRGWSPFVALQIEYSLLER-TPERELLPMARALGLGVTPWSPLGGGLLTGKYQRGEEGRAGEakgvTVGFGK 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 925114528 236 KNLANRSLVDDtlrkvngLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIplLTPEVVDRIE 314
Cdd:cd19080 238 LTERNWAIVDV-------VAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLT--LSPEQLARLD 307
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
16-317 |
2.83e-77 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 238.37 E-value: 2.83e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 16 LSYGAWvTFGNQLDV---KEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVVISTKLfWGGQGPND 92
Cdd:pfam00248 1 IGLGTW-QLGGGWGPiskEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVKRDKVVIATKV-PDGDGPWP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 93 KGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWavanrLDLV 172
Cdd:pfam00248 79 SGGSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKAL-----TKGK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 173 GPIVE-QPEYNLFSRHkVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADSRFALDnyknlaNRSLVDDTLRKV 251
Cdd:pfam00248 154 IPIVAvQVEYNLLRRR-QEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKGPGERRRL------LKKGTPLNLEAL 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 925114528 252 NGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDviPLLTPEVVDRIEAVV 317
Cdd:pfam00248 227 EALEEIAKEHGVSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALE--FPLSDEEVARIDELL 290
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
14-297 |
3.50e-75 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 230.87 E-value: 3.50e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 14 SQLSYGAWvTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGwRRSDVVISTKL-FWGGQGPND 92
Cdd:cd06660 1 SRLGLGTM-TFGGDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRG-NRDDVVIATKGgHPPGGDPSR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 93 KGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANRLDLV 172
Cdd:cd06660 79 SRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKAHGLP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 173 GPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGvltgkytkgnipadsrfaldnyknlanrslvddtlrkvn 252
Cdd:cd06660 159 GFAAVQPQYSLLDRSPMEEELLDWAEENGLPLLAYSPLARG--------------------------------------- 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 925114528 253 glkpiaaelgvsLAQLSIAWCASNPNVSSVITGATKESQIVENMK 297
Cdd:cd06660 200 ------------PAQLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
13-316 |
6.51e-75 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 232.09 E-value: 6.51e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 13 VSQLSYGAWV-----TFGNQlDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgwRRSDVVISTKLFwgg 87
Cdd:cd19085 1 VSRLGLGCWQfgggyWWGDQ-DDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALKG---RRDDVVIATKVS--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 88 qgPNDkgLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVAN 167
Cdd:cd19085 74 --PDN--LTPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAGR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 168 rldlvgPIVEQPEYNLFSRHkVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKG--NIPADSR---FALDNYKNLANrs 242
Cdd:cd19085 150 ------IDSNQLPYNLLWRA-IEYEILPFCREHGIGVLAYSPLAQGLLTGKFSSAedFPPGDARtrlFRHFEPGAEEE-- 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 925114528 243 lvddTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIplLTPEVVDRIEAV 316
Cdd:cd19085 221 ----TFEALEKLKEIADELGVTMAQLALAWVLQQPGVTSVIVGARNPEQLEENAAAVDLE--LSPSVLERLDEI 288
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
2-300 |
1.03e-73 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 229.60 E-value: 1.03e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 2 QYKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYA--NGRAEEIMGQAIR-DLGWRRSDVV 78
Cdd:cd19151 1 KYNRCGRSGLKLPAISLGLWHNFGDVDRYENSRAMLRRAFDLGITHFDLANNYGppPGSAEENFGRILKeDLKPYRDELI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 79 ISTK---LFWggQGP-NDKGlSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEW 154
Cdd:cd19151 81 ISTKagyTMW--PGPyGDWG-SKKYLIASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGISNY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 155 SAQQITEAWAVANrlDLVGP-IVEQPEYNLFSRHkVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGnIPADSRFALD 233
Cdd:cd19151 158 PPEEAREAAAILK--DLGTPcLIHQPKYSMFNRW-VEEGLLDVLEEEGIGCIAFSPLAQGLLTDRYLNG-IPEDSRAAKG 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925114528 234 NyKNLANRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALD 300
Cdd:cd19151 234 S-SFLKPEQITEEKLAKVRRLNEIAQARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGALD 299
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
3-315 |
7.28e-70 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 220.22 E-value: 7.28e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 3 YKNLGRSGLRVSQLSYGAWV----TFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgwRRSDVV 78
Cdd:cd19149 1 YRKLGKSGIEASVIGLGTWAigggPWWGGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKG---RRDKVV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 79 ISTK--LFW---GGQGPND-------KGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWA 146
Cdd:cd19149 78 LATKcgLRWdreGGSFFFVrdgvtvyKNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQGKI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 147 FYWGTSEWSAQQITEAWAVANrLDLVgpiveQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKG--NI 224
Cdd:cd19149 158 RAIGASNVSVEQIKEYVKAGQ-LDII-----QEKYSMLDR-GIEKELLPYCKKNNIAFQAYSPLEQGLLTGKITPDreFD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 225 PADSRFALDNYKnLANRSLVDDTLRKvngLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIpl 304
Cdd:cd19149 231 AGDARSGIPWFS-PENREKVLALLEK---WKPLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAEENAKAGDIR-- 304
|
330
....*....|.
gi 925114528 305 LTPEVVDRIEA 315
Cdd:cd19149 305 LSAEDIATMRS 315
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
2-300 |
2.04e-67 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 213.47 E-value: 2.04e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 2 QYKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYA--NGRAEEIMGQAIR-DLGWRRSDVV 78
Cdd:cd19150 1 QYRRCGKSGLKLPALSLGLWHNFGDDTPLETQRAILRTAFDLGITHFDLANNYGppPGSAEENFGRILReDFAGYRDELI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 79 ISTKL---FWggQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWS 155
Cdd:cd19150 81 ISTKAgydMW--PGPYGEWGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSYS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 156 AQQITEAWAVANRLDLvgP-IVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGnIPADSRFALDn 234
Cdd:cd19150 159 PERTREAAAILRELGT--PlLIHQPSYNMLNRWVEESGLLDTLQELGVGCIAFTPLAQGLLTDKYLNG-IPEGSRASKE- 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 925114528 235 yKNLANRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALD 300
Cdd:cd19150 235 -RSLSPKMLTEANLNSIRALNEIAQKRGQSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGALD 299
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
2-313 |
1.45e-66 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 211.31 E-value: 1.45e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 2 QYKNLGRSGLRVSQLSYGAW--VTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgwRRSDVVI 79
Cdd:cd19076 1 PTRKLGTQGLEVSALGLGCMgmSAFYGPADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKD---RRDEVVI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 80 STKlfWG-GQGPNDKGL----SRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEW 154
Cdd:cd19076 78 ATK--FGiVRDPGSGFRgvdgRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGLSEA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 155 SAQQITEAWAVAnrldlvgPIVE-QPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGN-IPADS---- 228
Cdd:cd19076 156 SADTIRRAHAVH-------PITAvQSEYSLWTR-DIEDEVLPTCRELGIGFVAYSPLGRGFLTGAIKSPEdLPEDDfrrn 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 229 --RFALDNYKnlANRSLVDDtlrkvngLKPIAAELGVSLAQLSIAWC-ASNPNVSSvITGATKESQIVENMKALDVIplL 305
Cdd:cd19076 228 npRFQGENFD--KNLKLVEK-------LEAIAAEKGCTPAQLALAWVlAQGDDIVP-IPGTKRIKYLEENVGALDVV--L 295
|
....*...
gi 925114528 306 TPEVVDRI 313
Cdd:cd19076 296 TPEELAEI 303
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-317 |
9.19e-65 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 206.37 E-value: 9.19e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 19 GAWVTFGNQlDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgwRRSDVVISTK--LFWGGQGPNDKGLS 96
Cdd:cd19102 15 GWGGGWGPQ-DDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKG---LRDRPIVATKcgLLWDEEGRIRRSLK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 97 RKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVanrldlvGPI- 175
Cdd:cd19102 91 PASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAI-------HPIa 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 176 VEQPEYNLFSRHkVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNI---PADSRFALDNYKNLANRSlvdDTLRKVN 252
Cdd:cd19102 164 SLQPPYSLLRRG-IEAEILPFCAEHGIGVIVYSPMQSGLLTGKMTPERVaslPADDWRRRSPFFQEPNLA---RNLALVD 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 925114528 253 GLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVipLLTPEVVDRIEAVV 317
Cdd:cd19102 240 ALRPIAERHGRTVAQLAIAWVLRRPEVTSAIVGARRPDQIDETVGAADL--RLTPEELAEIEALL 302
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
13-316 |
8.23e-64 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 204.72 E-value: 8.23e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 13 VSQLSYGAwVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYA-------NGRAEEIMGQAIRDLGwRRSDVVISTK--- 82
Cdd:cd19094 1 VSEICLGT-MTWGEQNTEAEAHEQLDYAFDEGVNFIDTAEMYPvppspetQGRTEEIIGSWLKKKG-NRDKVVLATKvag 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 83 --LFWGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPD------------------ASTPVEETVRAINWVID 142
Cdd:cd19094 79 pgEGITWPRGGGTRLDRENIREAVEGSLKRLGTDYIDLYQLHWPDrytplfgggyytepseeeDSVSFEEQLEALGELVK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 143 QGWAFYWGTSEWSAQQITEAWAVANRLDLVGPIVEQPEYNLFSRHKVESefLPLYSTY-GIGLTTWSPLASGVLTGKYTK 221
Cdd:cd19094 159 AGKIRHIGLSNETPWGVMKFLELAEQLGLPRIVSIQNPYSLLNRNFEEG--LAEACHReNVGLLAYSPLAGGVLTGKYLD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 222 GNI-PADSRFALdnYKNLANRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALD 300
Cdd:cd19094 237 GAArPEGGRLNL--FPGYMARYRSPQALEAVAEYVKLARKHGLSPAQLALAWVRSRPFVTSTIIGATTLEQLKENIDAFD 314
|
330
....*....|....*.
gi 925114528 301 VIplLTPEVVDRIEAV 316
Cdd:cd19094 315 VP--LSDELLAEIDAV 328
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
6-317 |
4.95e-63 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 202.26 E-value: 4.95e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 6 LGRSGLRVSQLSYGAWVTFGNQL--DVKEA--KALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRdlGWRRSDVVIST 81
Cdd:cd19083 4 LGKSDIDVNPIGLGTNAVGGHNLypNLDEEegKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLK--EYNRNEVVIAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 82 KlfwGGQ--GPNDKGL--SRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQ 157
Cdd:cd19083 82 K---GAHkfGGDGSVLnnSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSNFSLE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 158 QITEAwAVANRLDLVgpiveQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKgnipaDSRFALDNYKN 237
Cdd:cd19083 159 QLKEA-NKDGYVDVL-----QGEYNLLQR-EAEEDILPYCVENNISFIPYFPLASGLLAGKYTK-----DTKFPDNDLRN 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 238 ---LANRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIplLTPEVVDRIE 314
Cdd:cd19083 227 dkpLFKGERFSENLDKVDKLKSIADEKGVTVAHLALAWYLTRPAIDVVIPGAKRAEQVIDNLKALDVT--LTEEEIAFID 304
|
...
gi 925114528 315 AVV 317
Cdd:cd19083 305 ALF 307
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
15-316 |
7.78e-63 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 201.63 E-value: 7.78e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 15 QLSYGA--WVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQairdLGWRRSDVVISTKLFwGGQGPnd 92
Cdd:cd19075 2 KIILGTmtFGSQGRFTTAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGE----LGLGERGFKIDTKAN-PGVGG-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 93 kGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANRLDLV 172
Cdd:cd19075 75 -GLSPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKENGWV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 173 GPIVEQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKG-NIPADSRFALDN-----YKNLANRSLVDD 246
Cdd:cd19075 154 LPTVYQGMYNAITR-QVETELFPCLRKLGIRFYAYSPLAGGFLTGKYKYSeDKAGGGRFDPNNalgklYRDRYWKPSYFE 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 925114528 247 TLRKVnglKPIAAELGVSLAQLSIAWCASNPNVSS-----VITGATKESQIVENMKALDVIPLLtPEVVDRIEAV 316
Cdd:cd19075 233 ALEKV---EEAAEKEGISLAEAALRWLYHHSALDGekgdgVILGASSLEQLEENLAALEKGPLP-EEVVKAIDEA 303
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
1-309 |
3.97e-61 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 198.67 E-value: 3.97e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYA--NGRAEEIMGQAIR-DLGWRRSDV 77
Cdd:PRK09912 13 MQYRYCGKSGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGppPGSAEENFGRLLReDFAAYRDEL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 78 VISTKL---FWggQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEW 154
Cdd:PRK09912 93 IISTKAgydMW--PGPYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSY 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 155 SAQQiTEAWAVANRLDLVGPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGnIPADSRFALDN 234
Cdd:PRK09912 171 SPER-TQKMVELLREWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLNG-IPQDSRMHREG 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925114528 235 YK--NLANRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPLLTPEV 309
Cdd:PRK09912 249 NKvrGLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQALNNLTFSTEEL 325
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
10-314 |
5.34e-59 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 191.68 E-value: 5.34e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAW---VTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAirdLGWRRSDVVISTKLFWG 86
Cdd:cd19078 1 GLEVSAIGLGCMgmsHGYGPPPDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEA---LKPFRDQVVIATKFGFK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 87 GQGPNDKGL---SR----KHVVEGlraSLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQI 159
Cdd:cd19078 78 IDGGKPGPLgldSRpehiRKAVEG---SLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSEAGVETI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 160 TEAWAVAnrldlvgPIVE-QPEYNLFSRHkVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKG-NIPAD------SRFA 231
Cdd:cd19078 155 RRAHAVC-------PVTAvQSEYSMMWRE-PEKEVLPTLEELGIGFVPFSPLGKGFLTGKIDENtKFDEGddraslPRFT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 232 LDNYKnlANRSLVDdtlrkvnGLKPIAAELGVSLAQLSIAWC-ASNPNVSSvITGATKESQIVENMKALDVIplLTPEVV 310
Cdd:cd19078 227 PEALE--ANQALVD-------LLKEFAEEKGATPAQIALAWLlAKKPWIVP-IPGTTKLSRLEENIGAADIE--LTPEEL 294
|
....
gi 925114528 311 DRIE 314
Cdd:cd19078 295 REIE 298
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
12-314 |
4.62e-55 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 181.27 E-value: 4.62e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 12 RVSQLSYGAWvTFGNQL-------DVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGwRRSDVVISTK-- 82
Cdd:cd19093 1 EVSPLGLGTW-QWGDRLwwgygeyGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELG-DRDEVVIATKfa 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 83 -LFWggqgpndkGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDA-STPVEETVRAINWVIDQGWAFYWGTSEWSAQQIT 160
Cdd:cd19093 79 pLPW--------RLTRRSVVKALKASLERLGLDSIDLYQLHWPGPwYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 161 EAWAVANRLDlVGPIVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADSRFALDNYKNLAN 240
Cdd:cd19093 151 RAHKALKERG-VPLASNQVEYSLLYRDPEQNGLLPACDELGITLIAYSPLAQGLLTGKYSPENPPPGGRRRLFGRKNLEK 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 925114528 241 RSLVDDTLRKvnglkpIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDVipLLTPEVVDRIE 314
Cdd:cd19093 230 VQPLLDALEE------IAEKYGKTPAQVALNWLIAKGVV--PIPGAKNAEQAEENAGALGW--RLSEEEVAELD 293
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
11-298 |
3.37e-54 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 177.28 E-value: 3.37e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 11 LRVSQLSYGAWvTFGNQ----LDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgwRRSDVVISTKL--F 84
Cdd:cd19086 1 LEVSEIGFGTW-GLGGDwwgdVDDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKG---RRDKVVIATKFgnR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 85 WGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRP-DASTPVEETVRAINWVIDQGWAFYWGtseWSAQQITEAW 163
Cdd:cd19086 77 FDGGPERPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPpDEVLDNDELFEALEKLKQEGKIRAYG---VSVGDPEEAL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 164 AVANRLDLVgpiVEQPEYNLFSRHkVESEFLPLYSTYGIGLTTWSPLASGVLTGKytkgnipadsrfaldnyknlanrsl 243
Cdd:cd19086 154 AALRRGGID---VVQVIYNLLDQR-PEEELFPLAEEHGVGVIARVPLASGLLTGK------------------------- 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 925114528 244 vddtlrkvnglkpiaaelgvsLAQLSIAWCASNPNVSSVITGATKESQIVENMKA 298
Cdd:cd19086 205 ---------------------LAQAALRFILSHPAVSTVIPGARSPEQVEENAAA 238
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
10-314 |
6.01e-53 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 174.72 E-value: 6.01e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWVTFGNQL-----DVKEAKALLQACrDAGVNFFDNAEVYANGRAEEIMGQAIRdlGWRRSDVVISTKLF 84
Cdd:cd19072 1 GEEVPVLGLGTWGIGGGMSkdysdDKKAIEALRYAI-ELGINLIDTAEMYGGGHAEELVGKAIK--GFDREDLFITTKVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 85 wggqgPNdkGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWA 164
Cdd:cd19072 78 -----PD--HLKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 165 VANRldlvGPIV-EQPEYNLFSRHkVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNipadsrfaldnyknlanrsl 243
Cdd:cd19072 151 YLKK----GPIVaNQVEYNLFDRE-EESGLLPYCQKNGIAIIAYSPLEKGKLSNAKGSPL-------------------- 205
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 925114528 244 vddtlrkvngLKPIAAELGVSLAQLSIAWCASNPNVsSVITGATKESQIVENMKALDVIplLTPEVVDRIE 314
Cdd:cd19072 206 ----------LDEIAKKYGKTPAQIALNWLISKPNV-IAIPKASNIEHLEENAGALGWE--LSEEDLQRLD 263
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
14-300 |
1.27e-43 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 151.55 E-value: 1.27e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 14 SQLSYGAwVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYAN----GRAEEIMGQAIRDLGwRRSDVVISTKlfwGGQ- 88
Cdd:cd19082 1 SRIVLGT-ADFGTRIDEEEAFALLDAFVELGGNFIDTARVYGDwverGASERVIGEWLKSRG-NRDKVVIATK---GGHp 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 89 GPNDKG---LSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAV 165
Cdd:cd19082 76 DLEDMSrsrLSPEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASNWSTERIAEANAY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 166 ANRLDLVGPIVEQPEYNLFsrhKVESEFLP-------------LYSTYGIGLTTWSPLASGVLTGKYTKG-NIPADSRFA 231
Cdd:cd19082 156 AKAHGLPGFAASSPQWSLA---RPNEPPWPgptlvamdeemraWHEENQLPVFAYSSQARGFFSKRAAGGaEDDSELRRV 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 925114528 232 LDNYKNLAnrslvddTLRKVNGLkpiAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALD 300
Cdd:cd19082 233 YYSEENFE-------RLERAKEL---AEEKGVSPTQIALAYVLNQPFPTVPIIGPRTPEQLRDSLAAAD 291
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
10-292 |
1.34e-42 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 148.99 E-value: 1.34e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWVTFGNQ---LDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGwRRSDVVISTK--LF 84
Cdd:cd19148 1 DLPVSRIALGTWAIGGWMwggTDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYG-KRDRVVIATKvgLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 85 WGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQIteawa 164
Cdd:cd19148 80 WDEGGEVVRNSSPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFSPEQM----- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 165 vaNRLDLVGPI-VEQPEYNLFSRHkVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKgnipaDSRFALDNYKNLA---N 240
Cdd:cd19148 155 --ETFRKVAPLhTVQPPYNLFERE-IEKDVLPYARKHNIVTLAYGALCRGLLSGKMTK-----DTKFEGDDLRRTDpkfQ 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 925114528 241 RSLVDDTLRKVNGLKPIAAE-LGVSLAQLSIAWCASNPNVSSVITGATKESQI 292
Cdd:cd19148 227 EPRFSQYLAAVEELDKLAQErYGKSVIHLAVRWLLDQPGVSIALWGARKPEQL 279
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
9-315 |
4.62e-42 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 146.35 E-value: 4.62e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLfWggq 88
Cdd:COG0656 1 NGVEIPALGLGTW-----QLPGEEAAAAVRTALEAGYRHIDTAAMYGN---EEGVGEAIAASGVPREELFVTTKV-W--- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 89 gPNDkgLSRKHVVEGLRASLRRLDMDYVDVVYCHRPdASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANr 168
Cdd:COG0656 69 -NDN--HGYDDTLAAFEESLERLGLDYLDLYLIHWP-GPGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETG- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 169 ldlVGPIVEQPEYNLFSRhkvESEFLPLYSTYGIGLTTWSPLASGvltgkytkgnipadsrfaldnyknlanRSLVDDTL 248
Cdd:COG0656 144 ---VKPAVNQVELHPYLQ---QRELLAFCREHGIVVEAYSPLGRG---------------------------KLLDDPVL 190
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925114528 249 RKvnglkpIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDVIplLTPEVVDRIEA 315
Cdd:COG0656 191 AE------IAEKHGKTPAQVVLRWHLQRGVV--VIPKSVTPERIRENLDAFDFE--LSDEDMAAIDA 247
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
1-327 |
5.25e-41 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 145.66 E-value: 5.25e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAW---VTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYanGRAEEIMGQAIRDLGWRRSDV 77
Cdd:cd19144 1 IPTRTLGRNGPSVPALGFGAMglsAFYGPPKPDEERFAVLDAAFELGCTFWDTADIY--GDSEELIGRWFKQNPGKREKI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 78 VISTKLFWGGQGPNDKGLSR---KHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEW 154
Cdd:cd19144 79 FLATKFGIEKNVETGEYSVDgspEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIGLSEC 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 155 SAQQITEAWAVAnrldlvgPIVE-QPEYNLFSRhKVESEFLPLYST---YGIGLTTWSPLASGVLTGKYTKgniPAD--- 227
Cdd:cd19144 159 SAETLRRAHAVH-------PIAAvQIEYSPFSL-DIERPEIGVLDTcreLGVAIVAYSPLGRGFLTGAIRS---PDDfee 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 228 -------SRFALDNYKnlANRSLVDdtlrkvnGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALD 300
Cdd:cd19144 228 gdfrrmaPRFQAENFP--KNLELVD-------KIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALK 298
|
330 340
....*....|....*....|....*..
gi 925114528 301 VipLLTPEVVDRIEAVVQSKPKRTESY 327
Cdd:cd19144 299 V--KLTEEEEKEIREIAEEAEVVGERY 323
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
9-301 |
6.84e-41 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 144.24 E-value: 6.84e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVVISTK---LFW 85
Cdd:cd19092 2 EGLEVSRLVLGCMRLADWGESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALALNPGLREKIEIQTKcgiRLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 86 GGQGPNDKG---LSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITea 162
Cdd:cd19092 82 DDPRPGRIKhydTSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFTPSQIE-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 163 wAVANRLDLvgPIV-EQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASgvltGKYTKGNIPADSRfaldnyknlanr 241
Cdd:cd19092 160 -LLQSYLDQ--PLVtNQIELSLLHTEAIDDGTLDYCQLLDITPMAWSPLGG----GRLFGGFDERFQR------------ 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 242 slvddtLRKVngLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDV 301
Cdd:cd19092 221 ------LRAA--LEELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIRSAVKALDI 272
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
9-314 |
1.35e-40 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 143.92 E-value: 1.35e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGA----WVtfGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAE---EIMGQAIRDLGWRRSDVVIST 81
Cdd:cd19077 1 NGKLVGPIGLGLmgltWR--PNPTPDEEAFETMKAALDAGSNLWNGGEFYGPPDPHanlKLLARFFRKYPEYADKVVLSV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 82 KlfwGGQGPNDKG--LSRKHVVEGLRASLRRLDM-DYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQ 158
Cdd:cd19077 79 K---GGLDPDTLRpdGSPEAVRKSIENILRALGGtKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSEVSAET 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 159 ITEAWAVAnrldlvgPIVE-QPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGN-IPA-DSRFALDNY 235
Cdd:cd19077 156 IRRAHAVH-------PIAAvEVEYSLFSREIEENGVLETCAELGIPIIAYSPLGRGLLTGRIKSLAdIPEgDFRRHLDRF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 236 knlaNRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSV-ITGATKESQIVENMKALDVipLLTPEVVDRIE 314
Cdd:cd19077 229 ----NGENFEKNLKLVDALQELAEKKGCTPAQLALAWILAQSGPKIIpIPGSTTLERVEENLKAANV--ELTDEELKEIN 302
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
6-308 |
4.39e-40 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 142.57 E-value: 4.39e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 6 LGRSGLRVSQLSYGAW---VTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLgwRRSDVVISTK 82
Cdd:cd19145 5 LGSQGLEVSAQGLGCMglsGDYGAPKPEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKDG--PREKVQLATK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 83 L---FWGGQGPNDKGlSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQI 159
Cdd:cd19145 83 FgihEIGGSGVEVRG-DPAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSEASADTI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 160 TEAWAVAnrldlvgPIVE-QPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADS-------RFA 231
Cdd:cd19145 162 RRAHAVH-------PITAvQLEWSLWTR-DIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLEELLENSdvrkshpRFQ 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925114528 232 LDNYKNlaNRSLvddtLRKVNGLkpiAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVipLLTPE 308
Cdd:cd19145 234 GENLEK--NKVL----YERVEAL---AKKKGCTPAQLALAWVLHQGEDVVPIPGTTKIKNLNQNIGALSV--KLTKE 299
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-299 |
9.54e-40 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 140.03 E-value: 9.54e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAWVTFGnqldvkEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLgwRRSDVVIS 80
Cdd:cd19105 1 MPYRTLGKTGLKVSRLGFGGGGLPR------ESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGL--RRDKVFLA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLFWGgqgpnDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTP---VEETVRAINWVIDQGWAFYWGTSEWSAQ 157
Cdd:cd19105 73 TKASPR-----LDKKDKAELLKSVEESLKRLQTDYIDIYQLHGVDTPEErllNEELLEALEKLKKEGKVRFIGFSTHDNM 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 158 Q--ITEAwAVANRLDLVgpiveQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGvltgkytkGNIPADSRFALDNy 235
Cdd:cd19105 148 AevLQAA-IESGWFDVI-----MVAYNFLNQPAELEEALAAAAEKGIGVVAMKTLAGG--------YLQPALLSVLKAK- 212
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 925114528 236 knlanrslvddtlrkvnglkpiaaelGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKAL 299
Cdd:cd19105 213 --------------------------GFSLPQAALKWVLSNPRVDTVVPGMRNFAELEENLAAA 250
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
9-314 |
1.35e-39 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 140.08 E-value: 1.35e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWvTFGNQLD--VKEAKALLQACrDAGVNFFDNAEVYANGRAEEIMGQAIRDlgwRRSDVVISTKLFwg 86
Cdd:cd19138 7 DGTKVPALGQGTW-YMGEDPAkrAQEIEALRAGI-DLGMTLIDTAEMYGDGGSEELVGEAIRG---RRDKVFLVSKVL-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 87 gqgPNDKglSRKHVVEGLRASLRRLDMDYVDVVYCHRPdASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVA 166
Cdd:cd19138 80 ---PSNA--SRQGTVRACERSLRRLGTDYLDLYLLHWR-GGVPLAETVAAMEELKKEGKIRAWGVSNFDTDDMEELWAVP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 167 NRLDLVgpiVEQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLtgkytkgnipadsrfaldnyknLANRSLVDD 246
Cdd:cd19138 154 GGGNCA---ANQVLYNLGSR-GIEYDLLPWCREHGVPVMAYSPLAQGGL----------------------LRRGLLENP 207
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 925114528 247 TLRKvnglkpIAAELGVSLAQLSIAWCASNPNVSSvITGATKESQIVENMKALDVIplLTPEVVDRIE 314
Cdd:cd19138 208 TLKE------IAARHGATPAQVALAWVLRDGNVIA-IPKSGSPEHARENAAAADLE--LTEEDLAELD 266
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
13-301 |
5.71e-38 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 135.81 E-value: 5.71e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 13 VSQLSYGAW-----VTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgwRRSDVVISTKLFWGG 87
Cdd:cd19088 1 VSRLGYGAMrltgpGIWGPPADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHP---YPDDVVIATKGGLVR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 88 QGPNDKGL--SRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAV 165
Cdd:cd19088 78 TGPGWWGPdgSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 166 AnRLDLVgpiveQPEYNLFSRHkvESEFLPLYSTYGIGLTTWSPLASGVLtgkytkgnipadsrfaldnyknLANRSLVD 245
Cdd:cd19088 158 V-RIVSV-----QNRYNLANRD--DEGVLDYCEAAGIAFIPWFPLGGGDL----------------------AQPGGLLA 207
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 925114528 246 DtlrkvnglkpIAAELGVSLAQLSIAWC-ASNPNVsSVITGATKESQIVENMKALDV 301
Cdd:cd19088 208 E----------VAARLGATPAQVALAWLlARSPVM-LPIPGTSSVEHLEENLAAAGL 253
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
1-300 |
1.06e-36 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 133.45 E-value: 1.06e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAwVTFGN---QLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLgwRRSDV 77
Cdd:cd19163 1 MKYRKLGKTGLKVSKLGFGA-SPLGGvfgPVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKGI--PRDSY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 78 VISTKL-FWGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCH----RPDASTPVEETVRAINWVIDQGWAFYWGts 152
Cdd:cd19163 78 YLATKVgRYGLDPDKMFDFSAERITKSVEESLKRLGLDYIDIIQVHdiefAPSLDQILNETLPALQKLKEEGKVRFIG-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 153 ewsaqqITeawavANRLDLVGPIVEQpeynlfSRHKVE---------------SEFLPLYSTYGIGLTTWSPLASGVLTg 217
Cdd:cd19163 156 ------IT-----GYPLDVLKEVLER------SPVKIDtvlsychytlndtslLELLPFFKEKGVGVINASPLSMGLLT- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 218 kyTKGniPADSRFALDNYKNLANRslvddtlrkvnglkpiAAEL----GVSLAQLSIAWCASNPNVSSVITGATKESQIV 293
Cdd:cd19163 218 --ERG--PPDWHPASPEIKEACAK----------------AAAYcksrGVDISKLALQFALSNPDIATTLVGTASPENLR 277
|
....*..
gi 925114528 294 ENMKALD 300
Cdd:cd19163 278 KNLEAAE 284
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
2-316 |
6.33e-36 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 132.00 E-value: 6.33e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 2 QYKNLGRSGLRVSQLSYGA------WVTfGNQldvKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLgwrRS 75
Cdd:cd19104 1 KYRRFGRTGLKVSELTFGGggigglMGR-TTR---EEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKGL---PA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 76 DVVISTKLFWGGQGPNDKGlsrKHVVEGLRASLRRLDMDYVDVVYCH---RPDASTPVEETVRAINW------------V 140
Cdd:cd19104 74 GPYITTKVRLDPDDLGDIG---GQIERSVEKSLKRLKRDSVDLLQLHnriGDERDKPVGGTLSTTDVlglggvadaferL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 141 IDQGWAFYWGTSEWSAQQITEAWAVANRLDLVgpiveQPEYNLFSRHKVES-----------EFLPLYSTYGIGLTTWSP 209
Cdd:cd19104 151 RSEGKIRFIGITGLGNPPAIRELLDSGKFDAV-----QVYYNLLNPSAAEArprgwsaqdygGIIDAAAEHGVGVMGIRV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 210 LASGVLTGkytkgniPADSRFALDNYKNlanrSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKE 289
Cdd:cd19104 226 LAAGALTT-------SLDRGREAPPTSD----SDVAIDFRRAAAFRALAREWGETLAQLAHRFALSNPGVSTVLVGVKNR 294
|
330 340
....*....|....*....|....*..
gi 925114528 290 SQIVENMKALDVIPlLTPEVVDRIEAV 316
Cdd:cd19104 295 EELEEAVAAEAAGP-LPAENLARLEAL 320
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
14-298 |
1.39e-35 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 129.98 E-value: 1.39e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 14 SQLSYG-AWVTFG-NQLDVKEAKALLQACRDAGVNFFDNAEVYanGRAEEIMGQAIRdlGWRRSDVVISTKLFWGGQGPN 91
Cdd:cd19090 1 SALGLGtAGLGGVfGGVDDDEAVATIRAALDLGINYIDTAPAY--GDSEERLGLALA--ELPREPLVLSTKVGRLPEDTA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 92 DKglSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEET-----VRAINWVIDQGWAFYWG----TSEWSAQQITEa 162
Cdd:cd19090 77 DY--SADRVRRSVEESLERLGRDRIDLLMIHDPERVPWVDILapggaLEALLELKEEGLIKHIGlgggPPDLLRRAIET- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 163 wavaNRLDLvgpIVEQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYtkgnipadsrfalDNYKNLANRS 242
Cdd:cd19090 154 ----GDFDV---VLTANRYTLLDQ-SAADELLPAAARHGVGVINASPLGMGLLAGRP-------------PERVRYTYRW 212
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 925114528 243 LVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKA 298
Cdd:cd19090 213 LSPELLDRAKRLYELCDEHGVPLPALALRFLLRDPRISTVLVGASSPEELEQNVAA 268
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
14-298 |
1.38e-34 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 126.58 E-value: 1.38e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 14 SQLSYGAWVTFGNQLDV--KEAKALLQACRDAGVNFFDNAEVYanGRAEEIMGQAIRDLgwRRSDVVISTKLFWGGQGPN 91
Cdd:cd19095 1 SVLGLGTSGIGRVWGVPseAEAARLLNTALDLGINLIDTAPAY--GRSEERLGRALAGL--RRDDLFIATKVGTHGEGGR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 92 D-KGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAqqiTEAWAVA-NRL 169
Cdd:cd19095 77 DrKDFSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSGDGE---ELEAAIAsGVF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 170 DLVgpiveQPEYNLFSRHkvESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADSRFAldnyknlanrslvddtlr 249
Cdd:cd19095 154 DVV-----QLPYNVLDRE--EEELLPLAAEAGLGVIVNRPLANGRLRRRVRRRPLYADYARR------------------ 208
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 925114528 250 kvngLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKA 298
Cdd:cd19095 209 ----PEFAAEIGGATWAQAALRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
10-314 |
1.86e-33 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 123.83 E-value: 1.86e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWVTFGNQL----DVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgWRRSDVVISTKLFw 85
Cdd:cd19137 1 GEKIPALGLGTWGIGGFLTpdysRDEEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKD--FPREDLFIVTKVW- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 86 ggqgpnDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAV 165
Cdd:cd19137 78 ------PTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 166 AnRLDLVgpiVEQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLtgkytkgnipadsrfaldnyknlanrsLVD 245
Cdd:cd19137 152 S-QTPIV---CNQVKYNLEDRDPERDGLLEYCQKNGITVVAYSPLRRGLE---------------------------KTN 200
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 925114528 246 DTLRKvnglkpIAAELGVSLAQLSIAWCASNPNVSSvITGATKESQIVENMKALDVipLLTPEVVDRIE 314
Cdd:cd19137 201 RTLEE------IAKNYGKTIAQIALAWLIQKPNVVA-IPKAGRVEHLKENLKATEI--KLSEEEMKLLD 260
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-300 |
8.32e-33 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 122.83 E-value: 8.32e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 14 SQLSYGAwVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYA-------NGRAEEIMGQAIRDLGwRRSDVVISTKLfwg 86
Cdd:cd19752 1 SELCLGT-MYFGTRTDEETSFAILDRYVAAGGNFLDTANNYAfwteggvGGESERLIGRWLKDRG-NRDDVVIATKV--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 87 GQGPND--------KGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQ 158
Cdd:cd19752 76 GAGPRDpdggpespEGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 159 ITEAWAVANRLDLVGPIVEQPEYNLFSR-----HKVES----EFLPLYSTYG-IGLTTWSPLasgvLTGKYTKGNIPads 228
Cdd:cd19752 156 LERARQIARQQGWAEFSAIQQRHSYLRPrpgadFGVQRivtdELLDYASSRPdLTLLAYSPL----LSGAYTRPDRP--- 228
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 925114528 229 rfaldnyknLANRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAW-CASNPNVSSVItGATKESQIVENMKALD 300
Cdd:cd19752 229 ---------LPEQYDGPDSDARLAVLEEVAGELGATPNQVVLAWlLHRTPAIIPLL-GASTVEQLEENLAALD 291
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
1-318 |
1.10e-32 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 124.20 E-value: 1.10e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAwVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYA-------NGRAEEIMGQAIRDLGwR 73
Cdd:PRK10625 1 MQYHRIPHSSLEVSTLGLGT-MTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPvpprpetQGLTETYIGNWLAKRG-S 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 74 RSDVVISTKLfwggQGP---NDKG------LSRKHVVEGLRASLRRLDMDYVDVVYCHRP---------------DASTP 129
Cdd:PRK10625 79 REKLIIASKV----SGPsrnNDKGirpnqaLDRKNIREALHDSLKRLQTDYLDLYQVHWPqrptncfgklgyswtDSAPA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 130 VE--ETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANRLDLVGPIVEQPEYNLFSRhKVESEFLPLYSTYGIGLTTW 207
Cdd:PRK10625 155 VSllETLDALAEQQRAGKIRYIGVSNETAFGVMRYLHLAEKHDLPRIVTIQNPYSLLNR-SFEVGLAEVSQYEGVELLAY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 208 SPLASGVLTGKYTKGNIPADSRFALDNYknlANRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGAT 287
Cdd:PRK10625 234 SCLAFGTLTGKYLNGAKPAGARNTLFSR---FTRYSGEQTQKAVAAYVDIAKRHGLDPAQMALAFVRRQPFVASTLLGAT 310
|
330 340 350
....*....|....*....|....*....|.
gi 925114528 288 KESQIVENMKALDVIplLTPEVVDRIEAVVQ 318
Cdd:PRK10625 311 TMEQLKTNIESLHLT--LSEEVLAEIEAVHQ 339
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
10-317 |
4.35e-31 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 119.07 E-value: 4.35e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAwVTFGNQ-------LDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQ--AIRDlgwRRSDVVIS 80
Cdd:cd19146 8 GVRVSPLCLGA-MSFGEAwksmmgeCDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEwmASRG---NRDEMVLA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLFWGGQG-------PNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSE 153
Cdd:cd19146 84 TKYTTGYRRggpikikSNYQGNHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVLYLGVSD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 154 wsaqqiTEAWAV--AN---RLDLVGP-IVEQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGvltgkytKGNIPAD 227
Cdd:cd19146 164 ------TPAWVVskANayaRAHGLTQfVVYQGHWSAAFR-DFERDILPMCEAEGMALAPWGVLGQG-------QFRTEEE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 228 SRFALDNYKNLANRSLVDdtlRKVN-GLKPIAAELGVSLAQLSIAWC-ASNPNVSSVItGATKESQIVENMKALDVIplL 305
Cdd:cd19146 230 FKRRGRSGRKGGPQTEKE---RKVSeKLEKVAEEKGTAITSVALAYVmHKAPYVFPIV-GGRKVEHLKGNIEALGIS--L 303
|
330
....*....|..
gi 925114528 306 TPEVVDRIEAVV 317
Cdd:cd19146 304 SDEEIQEIEDAY 315
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
17-316 |
8.12e-31 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 117.82 E-value: 8.12e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 17 SYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgWRRSDVVISTKLFWGGQGPndkglS 96
Cdd:cd19103 18 GAGGDQVFGNHLDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKR--YPREDYIISTKFTPQIAGQ-----S 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 97 RKHVVEGLRASLRRLDMDYVDVVYCHRPdasTPVEE-TVRAINWViDQGWAFYWGTSEWSAQQITEAWAVANRLDLVGPI 175
Cdd:cd19103 91 ADPVADMLEGSLARLGTDYIDIYWIHNP---ADVERwTPELIPLL-KSGKVKHVGVSNHNLAEIKRANEILAKAGVSLSA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 176 VeQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGN-IPADSRFAlDNYknlaNRSLvdDTLRK-VNG 253
Cdd:cd19103 167 V-QNHYSLLYRSSEEAGILDYCKENGITFFAYMVLEQGALSGKYDTKHpLPEGSGRA-ETY----NPLL--PQLEElTAV 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 925114528 254 LKPIAAELGVSLAQLSIAWCASNPNVSsvITGATKESQIVENMKALDVIplLTPEVVDRIEAV 316
Cdd:cd19103 239 MAEIGAKHGASIAQVAIAWAIAKGTTP--IIGVTKPHHVEDAARAASIT--LTDDEIKELEQL 297
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
8-315 |
7.90e-30 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 113.89 E-value: 7.90e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 8 RSGLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLfWgg 87
Cdd:cd19140 3 VNGVRIPALGLGTY-----PLTGEECTRAVEHALELGYRHIDTAQMYGN---EAQVGEAIAASGVPRDELFLTTKV-W-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 88 qgPNDkgLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVAN 167
Cdd:cd19140 72 --PDN--YSPDDFLASVEESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 168 rldlvGPIV-EQPEYNLFSRhkvESEFLPLYSTYGIGLTTWSPLASGvltgkytkgnipadsrfaldnyknlanRSLVDD 246
Cdd:cd19140 148 -----APLFtNQVEYHPYLD---QRKLLDAAREHGIALTAYSPLARG---------------------------EVLKDP 192
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 925114528 247 TLRKvnglkpIAAELGVSLAQLSIAWCASNPNVsSVITGATKESQIVENMKALDVIplLTPEVVDRIEA 315
Cdd:cd19140 193 VLQE------IGRKHGKTPAQVALRWLLQQEGV-AAIPKATNPERLEENLDIFDFT--LSDEEMARIAA 252
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
15-314 |
3.61e-29 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 111.98 E-value: 3.61e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 15 QLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFWGGQGPNDkg 94
Cdd:cd19073 3 ALGLGTW-----QLRGDDCANAVKEALELGYRHIDTAEIYNN---EAEVGEAIAESGVPREDLFITTKVWRDHLRPED-- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 95 lsrkhVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANrldlVGP 174
Cdd:cd19073 73 -----LKKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISP----LPI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 175 IVEQPEYNLFSRhkvESEFLPLYSTYGIGLTTWSPLAsgvltgkytKGNIPADSRfaldnyknlanrslvddtlrkvngL 254
Cdd:cd19073 144 AVNQVEFHPFLY---QAELLEYCRENDIVITAYSPLA---------RGEVLRDPV------------------------I 187
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 255 KPIAAELGVSLAQLSIAWCASNPnvSSVITGATKESQIVENMKALDVipLLTPEVVDRIE 314
Cdd:cd19073 188 QEIAEKYDKTPAQVALRWLVQKG--IVVIPKASSEDHLKENLAIFDW--ELTSEDVAKID 243
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
1-318 |
1.33e-27 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 110.68 E-value: 1.33e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 1 MQYKNLGRSGLRVSQLSYGAWvtFGNQLDVKEAKALLQACRDAGVNFFDNAEVYanGRAEEIMGQAirdLGWRRSDVVIS 80
Cdd:COG1453 1 MQYRRLGKTGLEVSVLGFGGM--RLPRKDEEEAEALIRRAIDNGINYIDTARGY--GDSEEFLGKA---LKGPRDKVILA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLfwggqgPNDKGlSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVR------AINWVIDQGWAFYWGTSEW 154
Cdd:COG1453 74 TKL------PPWVR-DPEDMRKDLEESLKRLQTDYIDLYLIHGLNTEEDLEKVLKpggaleALEKAKAEGKIRHIGFSTH 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 155 SAQQITEAWAVANRLDLVgpiveQPEYN-LFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTgkytkgNIPADSRFALD 233
Cdd:COG1453 147 GSLEVIKEAIDTGDFDFV-----QLQYNyLDQDNQAGEEALEAAAEKGIGVIIMKPLKGGRLA------NPPEKLVELLC 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 234 NyknlanrslvddtlrkvnglkpiaaelGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALD-VIPlLTPEVVDR 312
Cdd:COG1453 216 P---------------------------PLSPAEWALRFLLSHPEVTTVLSGMSTPEQLDENLKTADnLEP-LTEEELAI 267
|
....*.
gi 925114528 313 IEAVVQ 318
Cdd:COG1453 268 LERLAE 273
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
14-300 |
2.68e-27 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 108.22 E-value: 2.68e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 14 SQLSYGAwVTFGNQLDVKEAKAL--LQACRDAGVNFFDNAEVYANGRAEEIMGQAIRdlGWRRSDVVISTKL-------- 83
Cdd:cd19162 1 PRLGLGA-ASLGNLARAGEDEAAatLDAAWDAGIRYFDTAPLYGLGLSERRLGAALA--RHPRAEYVVSTKVgrllepga 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 84 -FWGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPD--ASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQIT 160
Cdd:cd19162 78 aGRPAGADRRFDFSADGIRRSIEASLERLGLDRLDLVFLHDPDrhLLQALTDAFPALEELRAEGVVGAIGVGVTDWAALL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 161 EAwAVANRLDLVGPiveQPEYNLFsRHKVESEFLPLYSTYGIGLTTWSPLASGVLTgkytkGNIPADSRFaldNYknlan 240
Cdd:cd19162 158 RA-ARRADVDVVMV---AGRYTLL-DRRAATELLPLCAAKGVAVVAAGVFNSGILA-----TDDPAGDRY---DY----- 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 241 RSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALD 300
Cdd:cd19162 220 RPATPEVLARARRLAAVCRRYGVPLPAAALQFPLRHPAVASVVVGAASPAELRDNLALLR 279
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
31-303 |
1.04e-26 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 107.03 E-value: 1.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 31 KEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGwrRSDVVISTK---LFWGGQG-----PND--KGL----- 95
Cdd:cd19161 20 ADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKP--RDEFVLSTKvgrLLKPAREgsvpdPNGfvDPLpfeiv 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 96 ---SRKHVVEGLRASLRRLDMDYVDVVYCHrpDASTPVEETVRAINW---VIDQGW-------------AFYWGTSEWsa 156
Cdd:cd19161 98 ydySYDGIMRSFEDSLQRLGLNRIDILYVH--DIGVYTHGDRKERHHfaqLMSGGFkaleelkkagvikAFGLGVNEV-- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 157 QQITEAWAVANrLDLvgpIVEQPEYNLFSRHKVEsEFLPLYSTYGIGLTTWSPLASGVLTgkytKGNIPaDSRFaldNYk 236
Cdd:cd19161 174 QICLEALDEAD-LDC---FLLAGRYSLLDQSAEE-EFLPRCEQRGTSLVIGGVFNSGILA----TGTKS-GAKF---NY- 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 925114528 237 nlanRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALD-VIP 303
Cdd:cd19161 240 ----GDAPAEIISRVMEIEKICDAYNVPLAAAALQFPLRHPAVASVLTGARNPAQLRQNVEAFQtDIP 303
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
9-314 |
4.93e-26 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 105.29 E-value: 4.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQL-----SYG-AWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQ--AIRDLgwrRSDVVIS 80
Cdd:cd19147 6 AGIRVSPLilgamSIGdAWSGFMGSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEwmKSRKN---RDQIVIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLFW--------GGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINWVIDQGWAFYWGTS 152
Cdd:cd19147 83 TKFTTdykayevgKGKAVNYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGVS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 153 EwsaqqiTEAWAV--AN---RLDLVGPI-VEQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPA 226
Cdd:cd19147 163 D------TPAWVVsaANyyaTAHGKTPFsVYQGRWNVLNR-DFERDIIPMARHFGMALAPWDVLGGGKFQSKKAVEERKK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 227 DSRfALDNYKNLANRSlvDDTLRKVNGLKPIAAELGV-SLAQLSIAWCASN-PNVSSVItGATKESQIVENMKALDVIpl 304
Cdd:cd19147 236 NGE-GLRSFVGGTEQT--PEEVKISEALEKVAEEHGTeSVTAIALAYVRSKaPNVFPLV-GGRKIEHLKDNIEALSIK-- 309
|
330
....*....|
gi 925114528 305 LTPEVVDRIE 314
Cdd:cd19147 310 LTPEEIEYLE 319
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-304 |
5.66e-26 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 104.15 E-value: 5.66e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 16 LSYGAWVTFGnQLDVKEAKALLQACRDAGVNFFDNAEVYanGRAEEIMGQAIRdlgwRRSDVVISTKLfwgGQGPNDKGL 95
Cdd:cd19097 12 LDYGIANKSG-KPSEKEAKKILEYALKAGINTLDTAPAY--GDSEKVLGKFLK----RLDKFKIITKL---PPLKEDKKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 96 SRKHVVEGLRASLRRLDMDYVDVVYCHRP-DASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAvANRLDLVgp 174
Cdd:cd19097 82 DEAAIEASVEASLKRLKVDSLDGLLLHNPdDLLKHGGKLVEALLELKKEGLIRKIGVSVYSPEELEKALE-SFKIDII-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 175 iveQPEYNLFSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKgnIPADSRFALDNYKNLANrslvddtlrkvngl 254
Cdd:cd19097 159 ---QLPFNILDQRFLKSGLLAKLKKKGIEIHARSVFLQGLLLMEPDK--LPAKFAPAKPLLKKLHE-------------- 219
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 925114528 255 kpIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPL 304
Cdd:cd19097 220 --LAKKLGLSPLELALGFVLSLPEIDKIVVGVDSLEQLKEIIAAFKKPPL 267
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-317 |
6.14e-26 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 104.98 E-value: 6.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 15 QLSYGAWvtfgNQLDVKEAKALLQACRDAGVNFFDNAEVYanGRAEEIMGQAIRDLGW---RRSDVVISTKLFwggQGPN 91
Cdd:cd19101 11 QLSGGHG----GIRDEDAAVRAMAAYVDAGLTTFDCADIY--GPAEELIGEFRKRLRRerdAADDVQIHTKWV---PDPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 92 DKGLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTP-VEETVRAINWVIDQGWAFYWGTSEWSAQQITEAwavanrLD 170
Cdd:cd19101 82 ELTMTRAYVEAAIDRSLKRLGVDRLDLVQFHWWDYSDPgYLDAAKHLAELQEEGKIRHLGLTNFDTERLREI------LD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 171 LVGPIV-EQPEYNLFSRhKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTkgNIPADSRFALDN-----YKNLANR--- 241
Cdd:cd19101 156 AGVPIVsNQVQYSLLDR-RPENGMAALCEDHGIKLLAYGTLAGGLLSEKYL--GVPEPTGPALETrslqkYKLMIDEwgg 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925114528 242 -SLVDDTLRKvngLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVipLLTPEVVDRIEAVV 317
Cdd:cd19101 233 wDLFQELLRT---LKAIADKHGVSIANVAVRWVLDQPGVAGVIVGARNSEHIDDNVRAFSF--RLDDEDRAAIDAVL 304
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
15-314 |
9.27e-26 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 102.95 E-value: 9.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 15 QLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFWGGQGPndkg 94
Cdd:cd19071 3 LIGLGTY-----KLKPEETAEAVLAALEAGYRHIDTAAAYGN---EAEVGEAIRESGVPREELFITTKLWPTDHGY---- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 95 lsrKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPV------EETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANr 168
Cdd:cd19071 71 ---ERVREALEESLKDLGLDYLDLYLIHWPVPGKEGgskearLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAAR- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 169 ldlVGPIVEQPEYNLFSRHKVESEFLplySTYGIGLTTWSPLASGvltgkytkgnipadSRFALDnyknlanrslvDDTL 248
Cdd:cd19071 147 ---IKPAVNQIELHPYLQQKELVEFC---KEHGIVVQAYSPLGRG--------------RRPLLD-----------DPVL 195
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 925114528 249 RKvnglkpIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDVIplLTPEVVDRIE 314
Cdd:cd19071 196 KE------IAKKYGKTPAQVLLRWALQRGVV--VIPKSSNPERIKENLDVFDFE--LSEEDMAAID 251
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
32-303 |
5.02e-25 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 102.30 E-value: 5.02e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 32 EAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGwrRSDVVISTKLFW-----GGQGPNDKGL---SRKHVV-- 101
Cdd:cd19152 21 EAKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELG--REDYVISTKVGRllvplQEVEPTFEPGfwnPLPFDAvf 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 102 ----EGLRA----SLRRLDMDYVDVVYCHRPDASTPVEET-----------VRAINWVIDQGWAFYW--GTSEW-SAQQI 159
Cdd:cd19152 99 dysyDGILRsiedSLQRLGLSRIDLLSIHDPDEDLAGAESdehfaqaikgaFRALEELREEGVIKAIglGVNDWeVILRI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 160 TEA----WA-VANRldlvgpiveqpeYNLFSrHKVESEFLPLYSTYGIGLTTWSPLASGVLTGkytkgnipaDSRFALDN 234
Cdd:cd19152 179 LEEadldWVmLAGR------------YTLLD-HSAARELLPECEKRGVKVVNAGPFNSGFLAG---------GDNFDYYE 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 235 YknlanRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDV-IP 303
Cdd:cd19152 237 Y-----GPAPPELIARRDRIEALCEQHGVSLAAAALQFALAPPAVASVAPGASSPERVEENVALLATeIP 301
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
3-122 |
9.76e-25 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 99.86 E-value: 9.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 3 YKNLGRSGLRVSQLSYGAWVTFGnqLDVKEAKALLQACRDAGVNFFDNAEVYanGRAEEIMGQAIRDlgwRRSDVVISTK 82
Cdd:cd19100 1 YRRLGRTGLKVSRLGFGGGPLGR--LSQEEAAAIIRRALDLGINYFDTAPSY--GDSEEKIGKALKG---RRDKVFLATK 73
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 925114528 83 LFwggqgpndkGLSRKHVVEGLRASLRRLDMDYVDVVYCH 122
Cdd:cd19100 74 TG---------ARDYEGAKRDLERSLKRLGTDYIDLYQLH 104
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
3-318 |
7.35e-24 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 99.47 E-value: 7.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 3 YKNLGRSGLRVSQLSYGAwVTFGNQL-DVKEAKALlQACRDA---GVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVV 78
Cdd:PLN02587 1 LRELGSTGLKVSSVGFGA-SPLGSVFgPVSEEDAI-ASVREAfrlGINFFDTSPYYGGTLSEKVLGKALKALGIPREKYV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 79 ISTKLFWGGQGPNdkgLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDAST---PVEETVRAINWVIDQGWAFYWGTSEWS 155
Cdd:PLN02587 79 VSTKCGRYGEGFD---FSAERVTKSVDESLARLQLDYVDILHCHDIEFGSldqIVNETIPALQKLKESGKVRFIGITGLP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 156 AQQITEAwavanrLDLVGP-----IVEQPEYNLFSRHKVesEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADSRF 230
Cdd:PLN02587 156 LAIFTYV------LDRVPPgtvdvILSYCHYSLNDSSLE--DLLPYLKSKGVGVISASPLAMGLLTENGPPEWHPAPPEL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 231 aldnykNLANRSLVDDTLRKvnglkpiaaelGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVIPLLT--PE 308
Cdd:PLN02587 228 ------KSACAAAATHCKEK-----------GKNISKLALQYSLSNKDISTTLVGMNSVQQVEENVAAATELETSGidEE 290
|
330
....*....|
gi 925114528 309 VVDRIEAVVQ 318
Cdd:PLN02587 291 LLSEVEAILA 300
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
14-300 |
1.15e-23 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 97.63 E-value: 1.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 14 SQLSYGAW---VTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDlgWRRSDVVISTKL-FWGGQG 89
Cdd:cd19096 1 SVLGFGTMrlpESDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKE--GPREKFYLATKLpPWSVKS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 90 PNDkglSRKHvvegLRASLRRLDMDYVDVVYCHRPDASTpVEETVR------AINWVIDQGWAFYWG-TSEWSAQQITEA 162
Cdd:cd19096 79 AED---FRRI----LEESLKRLGVDYIDFYLLHGLNSPE-WLEKARkgglleFLEKAKKEGLIRHIGfSFHDSPELLKEI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 163 WAvANRLDLVgpiveQPEYNLFSRHKVESEFLPLY-STYGIGLTTWSPLASGVLtgkytkGNIPADSRFALDNYKnlanr 241
Cdd:cd19096 151 LD-SYDFDFV-----QLQYNYLDQENQAGRPGIEYaAKKGMGVIIMEPLKGGGL------ANNPPEALAILCGAP----- 213
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 925114528 242 slvddtlrkvnglkpiaaelgVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALD 300
Cdd:cd19096 214 ---------------------LSPAEWALRFLLSHPEVTTVLSGMSTPEQLDENIAAAD 251
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
10-322 |
2.72e-23 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 96.92 E-value: 2.72e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYG---AW-VTFGNQLDVKEAKALLQACRdAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFW 85
Cdd:cd19120 1 GSKIPAIAFGtgtAWyKSGDDDIQRDLVDSVKLALK-AGFRHIDTAEMYGN---EKEVGEALKESGVPREDLFITTKVSP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 86 GGqgpndkglsrKHVVEGLRASLRRLDMDYVDVVYCHRP----DASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITE 161
Cdd:cd19120 77 GI----------KDPREALRKSLAKLGVDYVDLYLIHSPffakEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 162 AWAVANrldlVGPIVEQPEYNLFSRHKvESEFLPLYSTYGIGLTTWSPLASgvlTGKYTKGnipadsrfaldnyknlanr 241
Cdd:cd19120 147 LLDTAK----IKPAVNQIEFHPYLYPQ-QPALLEYCREHGIVVSAYSPLSP---LTRDAGG------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 242 sLVDDTLRKvnglkpIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDviPLLTPEVVDRIEAVVQSKP 321
Cdd:cd19120 200 -PLDPVLEK------IAEKYGVTPAQVLLRWALQKGIV--VVTTSSKEERMKEYLEAFD--FELTEEEVEEIDKAGKQKH 268
|
.
gi 925114528 322 K 322
Cdd:cd19120 269 F 269
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
11-297 |
9.19e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 96.23 E-value: 9.19e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 11 LRVSQLSYGAWVTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDL----GWRRSDVVISTK---- 82
Cdd:cd19099 1 LTLSSLGLGTYRGDSDDETDEEYREALKAALDSGINVIDTAINYRGGRSERLIGKALRELiekgGIKRDEVVIVTKagyi 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 83 LFWGGQGPN---------DKGLSRKHVVEGLR-------------ASLRRLDMDYVDVVYCHRPDASTPVEETvRAINWV 140
Cdd:cd19099 81 PGDGDEPLRplkyleeklGRGLIDVADSAGLRhcispayledqieRSLKRLGLDTIDLYLLHNPEEQLLELGE-EEFYDR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 141 IDQGWAF-----------YWGTSEWSAQQITEAWAVANRLDLVGPIVEQPEYNlfsRHKVESEFLPLystygiglttwSP 209
Cdd:cd19099 160 LEEAFEAleeavaegkirYYGISTWDGFRAPPALPGHLSLEKLVAAAEEVGGD---NHHFKVIQLPL-----------NL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 210 LASGVLTGKYTKGNIpADSRFALDNYKNL---ANRSL-VDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPNVSSVITG 285
Cdd:cd19099 226 LEPEALTEKNTVKGE-ALSLLEAAKELGLgviASRPLnQGQLLGELRLADLLALPGGATLAQRALQFARSTPGVDSALVG 304
|
330
....*....|..
gi 925114528 286 ATKESQIVENMK 297
Cdd:cd19099 305 MRRPEHVDENLA 316
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
6-305 |
1.69e-20 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 89.52 E-value: 1.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 6 LGRSGLRVSQLSYGAWV---TFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGRAEEIMGQAIRDLGWRRSDVVISTK 82
Cdd:cd19153 5 LEIALGNVSPVGLGTAAlggVYGDGLEQDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALQVPRSSYTVATK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 83 LFWGGQGPNDkgLSRKHVVEGLRASLRRLDMDYVDVVYCHR---PDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQI 159
Cdd:cd19153 85 VGRYRDSEFD--YSAERVRASVATSLERLHTTYLDVVYLHDiefVDYDTLVDEALPALRTLKDEGVIKRIGIAGYPLDTL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 160 TEawaVANRLDLVGPIVEQPEYNL-FSRHKVESEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADSrfALDNYKNL 238
Cdd:cd19153 163 TR---ATRRCSPGSLDAVLSYCHLtLQDARLESDAPGLVRGAGPHVINASPLSMGLLTSQGPPPWHPASG--ELRHYAAA 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 925114528 239 ANRslvddtlrkvnglkpIAAELGVSLAQLSIAWCASNPN-VSSVITGATKESQIVENMKALDVIPLL 305
Cdd:cd19153 238 ADA---------------VCASVEASLPDLALQYSLAAHAgVGTVLLGPSSLAQLRSMLAAVDAVASL 290
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
9-323 |
4.48e-19 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 85.93 E-value: 4.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDL----GWRRSDVVISTKLF 84
Cdd:cd19154 8 NGVKMPLIGLGTW-----QSKGAEGITAVRTALKAGYRLIDTAFLYQN---EEAIGEALAELleegVVKREDLFITTKLW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 85 WGGQGPNDkglsrkhVVEGLRASLRRLDMDYVDVVYCHRP-------------------DASTPVEETVRAINWVIDQGW 145
Cdd:cd19154 80 THEHAPED-------VEEALRESLKKLQLEYVDLYLIHAPaafkddegesgtmengmsiHDAVDVEDVWRGMEKVYDEGL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 146 AFYWGTSEWSAQQITEAWAVAnrldLVGPIVEQPEYNLFSRHKVESEFLplySTYGIGLTTWSPLASgvltgkytkgniP 225
Cdd:cd19154 153 TKAIGVSNFNNDQIQRILDNA----RVKPHNNQVECHLYFPQKELVEFC---KKHNISVTSYATLGS------------P 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 226 ADSRFALDNYKNLAnRSLVDDTLrkvngLKPIAAELGVSLAQLSIAWCASNPnvSSVITGATKESQIVENMKALDVIplL 305
Cdd:cd19154 214 GRANFTKSTGVSPA-PNLLQDPI-----VKAIAEKHGKTPAQVLLRYLLQRG--IAVIPKSATPSRIKENFNIFDFS--L 283
|
330
....*....|....*...
gi 925114528 306 TPEVVDRIEAVvqSKPKR 323
Cdd:cd19154 284 SEEDMATLEEI--EKSLR 299
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
10-315 |
1.51e-17 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 80.88 E-value: 1.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFWGGQG 89
Cdd:cd19131 7 GNTIPQLGLGVW-----QVSNDEAASAVREALEVGYRSIDTAAIYGN---EEGVGKAIRASGVPREELFITTKLWNSDQG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 90 pndkglsRKHVVEGLRASLRRLDMDYVDVVYCHRPdasTPVE----ETVRAINWVIDQGWAFYWGTSEWSA---QQITEA 162
Cdd:cd19131 79 -------YDSTLRAFDESLRKLGLDYVDLYLIHWP---VPAQdkyvETWKALIELKKEGRVKSIGVSNFTIehlQRLIDE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 163 WAVAnrldlvgPIVEQPEYNLFSRHKVESEFLplySTYGIGLTTWSPLASGvltgkytkgnipadsrfaldnyknlanRS 242
Cdd:cd19131 149 TGVV-------PVVNQIELHPRFQQRELRAFH---AKHGIQTESWSPLGQG---------------------------GL 191
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 925114528 243 LVDDTLRKvnglkpIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDVIplLTPEVVDRIEA 315
Cdd:cd19131 192 LSDPVIGE------IAEKHGKTPAQVVIRWHLQNGLV--VIPKSVTPSRIAENFDVFDFE--LDADDMQAIAG 254
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
42-315 |
9.69e-17 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 78.16 E-value: 9.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 42 DAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFWggqgpndKGLSRKHVVEGLRASLRRLDMDYVDVVYC 121
Cdd:cd19139 25 ELGYRHIDTAQIYDN---EAAVGQAIAESGVPRDELFITTKIWI-------DNLSKDKLLPSLEESLEKLRTDYVDLTLI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 122 H--RPDASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAwavanrLDLVGP---IVEQPEYNLFSRHKVESEFLpl 196
Cdd:cd19139 95 HwpSPNDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEA------IAVVGAgaiATNQIELSPYLQNRKLVAHC-- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 197 ySTYGIGLTTWSPLASGvltgkytkgnipadsrfaldnyknlanRSLVDDTLRKvnglkpIAAELGVSLAQLSIAWCASN 276
Cdd:cd19139 167 -KQHGIHVTSYMTLAYG---------------------------KVLDDPVLAA------IAERHGATPAQIALAWAMAR 212
|
250 260 270
....*....|....*....|....*....|....*....
gi 925114528 277 PnvSSVITGATKESQIVENMKALDVIplLTPEVVDRIEA 315
Cdd:cd19139 213 G--YAVIPSSTKREHLRSNLLALDLT--LDADDMAAIAA 247
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
42-316 |
5.37e-16 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 77.07 E-value: 5.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 42 DAGVNFFDNAEVYANgraEEIMGQAIRDL----GWRRSDVVISTKLFWGGQGPNDkglsrkhVVEGLRASLRRLDMDYVD 117
Cdd:cd19123 36 EAGYRHIDCAAIYGN---EAEIGAALAEVfkegKVKREDLWITSKLWNNSHAPED-------VLPALEKTLADLQLDYLD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 118 VVYCHRP------------------DASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVA------NRLDLvG 173
Cdd:cd19123 106 LYLMHWPvalkkgvgfpesgedllsLSPIPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLATArikpavNQVEL-H 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 174 PIVEQPEYNLFSRHKveseflplystyGIGLTTWSPLASGVltgkYTKGNIPADSRFALDnyknlanrslvDDTLRKvng 253
Cdd:cd19123 185 PYLQQPELLAFCRDN------------GIHLTAYSPLGSGD----RPAAMKAEGEPVLLE-----------DPVINK--- 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 925114528 254 lkpIAAELGVSLAQLSIAWCASNPnvSSVITGATKESQIVENMKALDVIplLTPEVVDRIEAV 316
Cdd:cd19123 235 ---IAEKHGASPAQVLIAWAIQRG--TVVIPKSVNPERIQQNLEAAEVE--LDASDMATIAAL 290
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
10-319 |
6.43e-16 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 76.77 E-value: 6.43e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDL----GWRRSDVVISTKLFw 85
Cdd:cd19111 1 GFPMPVIGLGTY-----QSPPEEVRAAVDYALFVGYRHIDTALSYQN---EKAIGEALKWWlkngKLKREEVFITTKLP- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 86 ggqgpnDKGLSRKHVVEGLRASLRRLDMDYVDVVYCH-------------RPDASTPVEETVRAINWVIDQGWAFYWGTS 152
Cdd:cd19111 72 ------PVYLEFKDTEKSLEKSLENLKLPYVDLYLIHhpcgfvnkkdkgeRELASSDVTSVWRAMEALVSEGKVKSIGLS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 153 EWSAQQITEAWAVAnrldLVGPIVEQPEYNLFSRHKvesEFLPLYSTYGIGLTTWSPLASGVLTGKYTKGNIPADsrfal 232
Cdd:cd19111 146 NFNPRQINKILAYA----KVKPSNLQLECHAYLQQR---ELRKFCNKKNIVVTAYAPLGSPGRANQSLWPDQPDL----- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 233 dnyknlanrsLVDDTLRKvnglkpIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDVipLLTPEVVDR 312
Cdd:cd19111 214 ----------LEDPTVLA------IAKELDKTPAQVLLRFVLQRGTG--VLPKSTNKERIEENFEVFDF--ELTEEHFKK 273
|
....*..
gi 925114528 313 IEAVVQS 319
Cdd:cd19111 274 LKTLDRN 280
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
13-122 |
4.55e-15 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 74.24 E-value: 4.55e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 13 VSQLSYGAwVTFGNQL--DVKEAK--ALLQACRDAGVNFFDNAEVYanGRAEEIMGQAIRDL--GWRRSDVVISTKLfwG 86
Cdd:cd19164 13 LPPLIFGA-ATFSYQYttDPESIPpvDIVRRALELGIRAFDTSPYY--GPSEIILGRALKALrdEFPRDTYFIITKV--G 87
|
90 100 110
....*....|....*....|....*....|....*.
gi 925114528 87 GQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVYCH 122
Cdd:cd19164 88 RYGPDDFDYSPEWIRASVERSLRRLHTDYLDLVYLH 123
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
21-320 |
8.60e-15 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 73.19 E-value: 8.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 21 WVTFGnQLDVKEAKALLQACRDA---GVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFWGGQGpNDKGLsr 97
Cdd:cd19157 12 WLGLG-VFKVEEGSEVVNAVKTAlknGYRSIDTAAIYGN---EEGVGKGIKESGIPREELFITSKVWNADQG-YDSTL-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 98 khvvEGLRASLRRLDMDYVDVVYCHRPdASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANrldlVGPIVE 177
Cdd:cd19157 85 ----KAFEASLERLGLDYLDLYLIHWP-VKGKYKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAE----IVPMVN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 178 QPEYN-LFSRHKVEsEFLplySTYGIGLTTWSPLASGVLtgkytkgnipadsrfaLDNyknlanrslvdDTlrkvngLKP 256
Cdd:cd19157 156 QVEFHpRLTQKELR-DYC---KKQGIQLEAWSPLMQGQL----------------LDN-----------PV------LKE 198
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 925114528 257 IAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDVipLLTPEVVDRIEAVVQSK 320
Cdd:cd19157 199 IAEKYNKSVAQVILRWDLQNGVV--TIPKSIKEHRIIENADVFDF--ELSQEDMDKIDALNENL 258
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
9-318 |
1.84e-14 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 72.30 E-value: 1.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWVTFGNQLDVKEAkaLLQACRdAGVNFFDNAEVYAngrAEEIMGQAI---RDLG--WRRSDVVISTKL 83
Cdd:cd19124 1 SGQTMPVIGMGTASDPPSPEDIKAA--VLEAIE-VGYRHFDTAAAYG---TEEALGEALaeaLRLGlvKSRDELFVTSKL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 84 fWggqgPNDkgLSRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTP----------------VEETVRAINWVIDQGWAF 147
Cdd:cd19124 75 -W----CSD--AHPDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKPgkfsfpieeedflpfdIKGVWEAMEECQRLGLTK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 148 YWGTSEWSAQQITEAWAVANrldlVGPIVEQPEYNLFSRHKVESEFLplySTYGIGLTTWSPLASGvltgkytkgnipad 227
Cdd:cd19124 148 AIGVSNFSCKKLQELLSFAT----IPPAVNQVEMNPAWQQKKLREFC---KANGIHVTAYSPLGAP-------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 228 srfaldNYKNLANRSLVDDTLRKvnglkpIAAELGVSLAQLSIAWCASNPnvSSVITGATKESQIVENMKALDVipLLTP 307
Cdd:cd19124 207 ------GTKWGSNAVMESDVLKE------IAAAKGKTVAQVSLRWVYEQG--VSLVVKSFNKERMKQNLDIFDW--ELTE 270
|
330
....*....|.
gi 925114528 308 EVVDRIEAVVQ 318
Cdd:cd19124 271 EDLEKISEIPQ 281
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
10-315 |
2.37e-14 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 72.05 E-value: 2.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWVTFGNQldvkEAKALLQACRDaGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFWGGQG 89
Cdd:cd19127 6 GVEMPALGLGVFQTPPEE----TADAVATALAD-GYRLIDTAAAYGN---EREVGEGIRRSGVDRSDIFVTTKLWISDYG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 90 pNDKGLsrkhvvEGLRASLRRLDMDYVDVVYCHRPdASTPVEETV---RAINWVIDQGWAFYWGTSEWSAQQITEawaVA 166
Cdd:cd19127 78 -YDKAL------RGFDASLRRLGLDYVDLYLLHWP-VPNDFDRTIqayKALEKLLAEGRVRAIGVSNFTPEHLER---LI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 167 NRLDLVgPIVEQPEYNLFSRHKVESEFlplYSTYGIGLTTWSPLAsGVLTgkYTKGNIPadsrfaldnyknlANRSLVDD 246
Cdd:cd19127 147 DATTVV-PAVNQVELHPYFSQKDLRAF---HRRLGIVTQAWSPIG-GVMR--YGASGPT-------------GPGDVLQD 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 925114528 247 TLrkvngLKPIAAELGVSLAQLSIAWCASNPnvSSVITGATKESQIVENMKALDVIplLTPEVVDRIEA 315
Cdd:cd19127 207 PT-----ITGLAEKYGKTPAQIVLRWHLQNG--VSAIPKSVHPERIAENIDIFDFA--LSAEDMAAIDA 266
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
10-316 |
3.21e-14 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 71.31 E-value: 3.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWVTfgnqLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLfWGgqg 89
Cdd:cd19126 6 GTRMPWLGLGVFQT----PDGDETERAVQTALENGYRSIDTAAIYKN---EEGVGEAIRESGVPREELFVTTKL-WN--- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 90 pNDKGLSRkhVVEGLRASLRRLDMDYVDVVYCHRPdASTPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANrl 169
Cdd:cd19126 75 -DDQRARR--TEDAFQESLDRLGLDYVDLYLIHWP-GKDKFIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHAD-- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 170 dlVGPIVEQPEYNLFSRHKVESEFLplySTYGIGLTTWSPLASGVLtgkytkgnipadsrfaldnyknLANRSLVDdtlr 249
Cdd:cd19126 149 --VVPAVNQVEFHPYLTQKELRGYC---KSKGIVVEAWSPLGQGGL----------------------LSNPVLAA---- 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925114528 250 kvnglkpIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDVipLLTPEVVDRIEAV 316
Cdd:cd19126 198 -------IGEKYGKSAAQVVLRWDIQHGVV--TIPKSVHASRIKENADIFDF--ELSEDDMTAIDAL 253
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
10-316 |
3.30e-14 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 71.39 E-value: 3.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWvtfgNQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFWGGQG 89
Cdd:cd19156 6 GVEMPRLGLGVW----RVQDGAEAENAVKWAIEAGYRHIDTAAIYKN---EEGVGQGIRESGVPREEVFVTTKLWNSDQG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 90 pNDKGLSrkhvveGLRASLRRLDMDYVDVVYCHRPDASTPVeETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANrl 169
Cdd:cd19156 79 -YESTLA------AFEESLEKLGLDYVDLYLIHWPVKGKFK-DTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCK-- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 170 dlVGPIVEQPEYNLFSRHKVESEFLplySTYGIGLTTWSPLASGVLtgkytkgnipadsrfaLDNYKnlanrslvddtlr 249
Cdd:cd19156 149 --VAPMVNQIELHPLLTQEPLRKFC---KEKNIAVEAWSPLGQGKL----------------LSNPV------------- 194
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 925114528 250 kvngLKPIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDVipLLTPEVVDRIEAV 316
Cdd:cd19156 195 ----LKAIGKKYGKSAAQVIIRWDIQHGII--TIPKSVHEERIQENFDVFDF--ELTAEEIRQIDGL 253
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
35-308 |
1.06e-13 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 70.05 E-value: 1.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 35 ALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFwggqgPNDKGLSRkhVVEGLRASLRRLDMD 114
Cdd:cd19135 30 AVVYALKECGYRHIDTAKRYGC---EELLGKAIKESGVPREDLFLTTKLW-----PSDYGYES--TKQAFEASLKRLGVD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 115 YVDVVYCHRPDASTPV-------EETVRAINWVIDQGWAFYWGTSEWSAQ---QITEAWAVAnrldlvgPIVEQPEYNLF 184
Cdd:cd19135 100 YLDLYLLHWPDCPSSGknvketrAETWRALEELYDEGLCRAIGVSNFLIEhleQLLEDCSVV-------PHVNQVEFHPF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 185 SRHKVESEFLplySTYGIGLTTWSPLASGvltgkytkgnipadsrfaldnyknlanRSLVDDTLRKvnglkpIAAELGVS 264
Cdd:cd19135 173 QNPVELIEYC---RDNNIVFEGYCPLAKG---------------------------KALEEPTVTE------LAKKYQKT 216
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 925114528 265 LAQLSIAWCASNPNVssVITGATKESQIVENMKALDVIplLTPE 308
Cdd:cd19135 217 PAQILIRWSIQNGVV--TIPKSTKEERIKENCQVFDFS--LSEE 256
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
34-316 |
1.20e-13 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 69.58 E-value: 1.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 34 KALLQACRdAGVNFFDNAEVYANgraEEIMGQAIRDLGWR----RSDVVISTKLfwggqGPNDKGLSRkhVVEGLRASLR 109
Cdd:cd19136 19 QAVDAALK-AGYRLIDTASVYRN---EADIGKALRDLLPKyglsREDIFITSKL-----APKDQGYEK--ARAACLGSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 110 RLDMDYVDVVYCHRP-----DASTPVEETVRAINW-----VIDQGWAFYWGTSEWSAQQITEAWAVANrldlVGPIVEQP 179
Cdd:cd19136 88 RLGTDYLDLYLIHWPgvqglKPSDPRNAELRRESWraledLYKEGKLRAIGVSNYTVRHLEELLKYCE----VPPAVNQV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 180 EYNlfsRHKVESEFLPLYSTYGIGLTTWSPLASGVLtgkytkgnipadsrfaldnyknlanRSLVDDTLRKvnglkpIAA 259
Cdd:cd19136 164 EFH---PHLVQKELLKFCKDHGIHLQAYSSLGSGDL-------------------------RLLEDPTVLA------IAK 209
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 925114528 260 ELGVSLAQLSIAWCASNpNVsSVITGATKESQIVENMKALDVIplLTPEVVDRIEAV 316
Cdd:cd19136 210 KYGRTPAQVLLRWALQQ-GI-GVIPKSTNPERIAENIKVFDFE--LSEEDMAELNAL 262
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
9-297 |
1.22e-13 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 70.22 E-value: 1.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWVTFGNQLdvkeAKALLQACRdAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLfWGGQ 88
Cdd:cd19117 10 TGAEIPAVGLGTWQSKPNEV----AKAVEAALK-AGYRHIDTAAIYGN---EEEVGQGIKDSGVPREEIFITTKL-WCTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 89 gpndkglsRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEETVRAINW----VIDQGWAFY--W------------- 149
Cdd:cd19117 81 --------HRRVEEALDQSLKKLGLDYVDLYLMHWPVPLDPDGNDFLFKKDdgtkDHEPDWDFIktWelmqklpatgkvk 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 150 --GTSEWS--------AQQITEAWAVANRLDLvGPIVEQPEYNLFSRHKveseflplystyGIGLTTWSPLASgvltgky 219
Cdd:cd19117 153 aiGVSNFSiknlekllASPSAKIVPAVNQIEL-HPLLPQPKLVDFCKSK------------GIHATAYSPLGS------- 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 925114528 220 tkgnipadsrfaldnyknlanrslVDDTLRKVNGLKPIAAELGVSLAQLSIAWCASNPnvSSVITGATKESQIVENMK 297
Cdd:cd19117 213 ------------------------TNAPLLKEPVIIKIAKKHGKTPAQVIISWGLQRG--YSVLPKSVTPSRIESNFK 264
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
31-183 |
1.77e-13 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 69.62 E-value: 1.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 31 KEAKALLQACR---DAGVNFFDNAEVYANgraEEIMGQAIRDL----GWRRSDVVISTKLfWggqgpNDKGlSRKHVVEG 103
Cdd:cd19116 22 KDDEGVRQAVKhaiEAGYRHIDTAYLYGN---EAEVGEAIREKiaegVVKREDLFITTKL-W-----NSYH-EREQVEPA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 104 LRASLRRLDMDYVDVVYCHRPDASTPVE----------------ETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVAN 167
Cdd:cd19116 92 LRESLKRLGLDYVDLYLIHWPVAFKENNdsesngdgslsdidylETWRGMEDLVKLGLTRSIGVSNFNSEQINRLLSNCN 171
|
170
....*....|....*.
gi 925114528 168 rldlVGPIVEQPEYNL 183
Cdd:cd19116 172 ----IKPAVNQIEVHP 183
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
15-313 |
2.28e-13 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 69.09 E-value: 2.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 15 QLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANGRA-EEIMGQAIRDLGWRRSDVVISTKLFWGGQGPndk 93
Cdd:cd19128 3 RLGFGTY-----KITESESKEAVKNAIKAGYRHIDCAYYYGNEAFiGIAFSEIFKDGGVKREDLFITSKLWPTMHQP--- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 94 glsrKHVVEGLRASLRRLDMDYVDVVYCHRP-------------------DASTPVEETVRAINWVIDQGWAFYWGTSEW 154
Cdd:cd19128 75 ----ENVKEQLLITLQDLQLEYLDLFLIHWPlafdmdtdgdprddnqiqsLSKKPLEDTWRAMEQCVDEKLTKNIGVSNY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 155 SAQQITEAWAVANrldlVGPIVEQPEYNLFSRHKVESEFLplySTYGIGLTTWSPLAsgvltGKYtkgnipADSRFALDN 234
Cdd:cd19128 151 STKLLTDLLNYCK----IKPFMNQIECHPYFQNDKLIKFC---IENNIHVTAYRPLG-----GSY------GDGNLTFLN 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 235 yknlanrslvDDTlrkvngLKPIAAELGVSLAQLSIAWCASN-PNVSSVITGATKESQIVENMKALDVipLLTPEVVDRI 313
Cdd:cd19128 213 ----------DSE------LKALATKYNTTPPQVIIAWHLQKwPKNYSVIPKSANKSRCQQNFDINDL--ALTKEDMDAI 274
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
10-213 |
1.42e-12 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 66.44 E-value: 1.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWvtfgnQL-DVKEAKallQACRDA---GVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLfW 85
Cdd:cd19133 6 GVEMPILGFGVF-----QIpDPEECE---RAVLEAikaGYRLIDTAAAYGN---EEAVGRAIKKSGIPREELFITTKL-W 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 86 ggqgPNDKGLSRkhVVEGLRASLRRLDMDYVDVVYCHRP-----DASTPVEE-----TVRAInwvidqgwafywGTSEWS 155
Cdd:cd19133 74 ----IQDAGYEK--AKKAFERSLKRLGLDYLDLYLIHQPfgdvyGAWRAMEElykegKIRAI------------GVSNFY 135
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 925114528 156 AQQITEaWAVANRldlVGPIVEQPEYNLFSRHKVESEFLplySTYGIGLTTWSPLASG 213
Cdd:cd19133 136 PDRLVD-LILHNE---VKPAVNQIETHPFNQQIEAVEFL---KKYGVQIEAWGPFAEG 186
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
27-300 |
3.39e-12 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 65.65 E-value: 3.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 27 QLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLfwggqGPNDKGLSRKhvVEGLRA 106
Cdd:cd19134 20 ELSDDEAERSVSAALEAGYRLIDTAAAYGN---EAAVGRAIAASGIPRGELFVTTKL-----ATPDQGFTAS--QAACRA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 107 SLRRLDMDYVDVVYCHRPDAST-PVEETVRAINWVIDQGWAFYWGTSEWSAQQITeawavanrlDLVGPIVEQPEYNLFS 185
Cdd:cd19134 90 SLERLGLDYVDLYLIHWPAGREgKYVDSWGGLMKLREEGLARSIGVSNFTAEHLE---------NLIDLTFFTPAVNQIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 186 RHKV--ESEFLPLYSTYGIGLTTWSPLASGVLtgkytkgnipadsrfaLDNyknlanrslvddtlrkvNGLKPIAAELGV 263
Cdd:cd19134 161 LHPLlnQAELRKVNAQHGIVTQAYSPLGVGRL----------------LDN-----------------PAVTAIAAAHGR 207
|
250 260 270
....*....|....*....|....*....|....*..
gi 925114528 264 SLAQLSIAWCASNPNVssVITGATKESQIVENMKALD 300
Cdd:cd19134 208 TPAQVLLRWSLQLGNV--VISRSSNPERIASNLDVFD 242
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
49-301 |
3.92e-12 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 65.43 E-value: 3.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 49 DNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLfWGGQgpndkgLSRKHVVEGLRASLRRLDMDYVDVVYCH--RPDA 126
Cdd:PRK11172 34 DTAQIYDN---EAAVGQAIAESGVPRDELFITTKI-WIDN------LAKDKLIPSLKESLQKLRTDYVDLTLIHwpSPND 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 127 STPVEETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAVANRLDLVGPIVEQPEYnLFSRHKVesEFLplySTYGIGLTT 206
Cdd:PRK11172 104 EVSVEEFMQALLEAKKQGLTREIGISNFTIALMKQAIAAVGAENIATNQIELSPY-LQNRKVV--AFA---KEHGIHVTS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 207 WSPLASGvltgkytkgnipadsrfaldnyknlanRSLVDDTLRKvnglkpIAAELGVSLAQLSIAWCASNPnvSSVITGA 286
Cdd:PRK11172 178 YMTLAYG---------------------------KVLKDPVIAR------IAAKHNATPAQVILAWAMQLG--YSVIPSS 222
|
250
....*....|....*
gi 925114528 287 TKESQIVENMKALDV 301
Cdd:PRK11172 223 TKRENLASNLLAQDL 237
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
10-318 |
6.06e-12 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 64.60 E-value: 6.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFWGGQG 89
Cdd:cd19132 4 GTQIPAIGFGTY-----PLKGDEGVEAVVAALQAGYRLLDTAFNYEN---EGAVGEAVRRSGVPREELFVTTKLPGRHHG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 90 pndkglsRKHVVEGLRASLRRLDMDYVDVVYCHRPDASTPVE-ETVRAINWVIDQGWAFYWGTSEWSAQQIteawavaNR 168
Cdd:cd19132 76 -------YEEALRTIEESLYRLGLDYVDLYLIHWPNPSRDLYvEAWQALIEAREEGLVRSIGVSNFLPEHL-------DR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 169 L-DLVG--PIVEQPE-YNLFSRhkveSEFLPLYSTYGIGLTTWSPLASGvltgkytkgnipadsrfaldnyknlanRSLV 244
Cdd:cd19132 142 LiDETGvtPAVNQIElHPYFPQ----AEQRAYHREHGIVTQSWSPLGRG---------------------------SGLL 190
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 925114528 245 DDTLrkvngLKPIAAELGVSLAQLSIAWcASNPNVSSVITGATKESQIvENMKALDVIplLTPEVVDRIEAVVQ 318
Cdd:cd19132 191 DEPV-----IKAIAEKHGKTPAQVVLRW-HVQLGVVPIPKSANPERQR-ENLAIFDFE--LSDEDMAAIAALDR 255
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
9-315 |
6.86e-12 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 65.10 E-value: 6.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWVTFGNQldVKEAkalLQACRDAGVNFFDNAEVYANgraEEIMGQAIR-----DLGWRRSDVVISTKL 83
Cdd:cd19106 3 TGQKMPLIGLGTWKSKPGQ--VKAA---VKYALDAGYRHIDCAAVYGN---EQEVGEALKekvgpGKAVPREDLFVTSKL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 84 FWGGQGPNDkglsrkhVVEGLRASLRRLDMDYVDVVYCHRPDA-------------------STPVEETVRAINWVIDQG 144
Cdd:cd19106 75 WNTKHHPED-------VEPALRKTLKDLQLDYLDLYLIHWPYAfergdnpfpknpdgtirydSTHYKETWKAMEKLVDKG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 145 WAFYWGTSEWSAQQITEAWAVANrldlVGPIVEQPEYNlfsRHKVESEFLPLYSTYGIGLTTWSPLASgvltgkytkgni 224
Cdd:cd19106 148 LVKAIGLSNFNSRQIDDILSVAR----IKPAVLQVECH---PYLAQNELIAHCKARGLVVTAYSPLGS------------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 225 pADSRFALDNyknlaNRSLVDDTlrkvnGLKPIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDVIpl 304
Cdd:cd19106 209 -PDRPWAKPD-----EPVLLEEP-----KVKALAKKYNKSPAQILLRWQVQRGVV--VIPKSVTPSRIKQNIQVFDFT-- 273
|
330
....*....|.
gi 925114528 305 LTPEVVDRIEA 315
Cdd:cd19106 274 LSPEEMKQLDA 284
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
9-316 |
1.28e-11 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 63.97 E-value: 1.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWVTFGNQLdvkeAKALLQACRdAGVNFFDNAEVYANgraEEIMGQAIRDL-----GWRRSDVVISTKL 83
Cdd:cd19118 3 TGNKIPAIGLGTWQAEPGEV----GAAVKIALK-AGYRHLDLAKVYQN---QHEVGQALKELlkeepGVKREDLFITSKL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 84 fWggqgpNDKGlSRKHVVEGLRASLRRLDMDYVDVVYCHRP------------------------DASTPVEETVRAINW 139
Cdd:cd19118 75 -W-----NNSH-RPEYVEPALDDTLKELGLDYLDLYLIHWPvafkptgdlnpltavptnggevdlDLSVSLVDTWKAMVE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 140 VIDQGWAFYWGTSEWSA---QQITEAWAVAnrldlvgPIVEQPEynlfsRHKV--ESEFLPLYSTYGIGLTTWSPLasgv 214
Cdd:cd19118 148 LKKTGKVKSIGVSNFSIdhlQAIIEETGVV-------PAVNQIE-----AHPLllQDELVDYCKSKNIHITAYSPL---- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 215 ltGKYTKGNIPadsrfaldnyknlanrsLVDDTlrkvnGLKPIAAELGVSLAQLSIAWCASNPNvsSVITGATKESQIVE 294
Cdd:cd19118 212 --GNNLAGLPL-----------------LVQHP-----EVKAIAAKLGKTPAQVLIAWGIQRGH--SVIPKSVTPSRIRS 265
|
330 340
....*....|....*....|..
gi 925114528 295 NMKALDviplLTPEVVDRIEAV 316
Cdd:cd19118 266 NFEQVE----LSDDEFNAVTAL 283
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
10-324 |
3.74e-11 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 62.93 E-value: 3.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDlgW------RRSDVVISTKL 83
Cdd:cd19155 9 GEKMPVVGLGTW-----QSSPEEIETAVDTALEAGYRHIDTAYVYRN---EAAIGNVLKK--WidsgkvKREELFIVTKL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 84 FWGGqgpndkglSRKHVVEG-LRASLRRLDMDYVDVVYCHRP---------------------DASTPVEETVRAINWVI 141
Cdd:cd19155 79 PPGG--------NRREKVEKfLLKSLEKLQLDYVDLYLIHFPvgslskeddsgkldptgehkqDYTTDLLDIWKAMEAQV 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 142 DQGWAFYWGTSEWSAQQITEAWAVANrldlVGPIVEQPEYNLFSRHKVESEFLplySTYGIGLTTWSPLASGVLTGKYTK 221
Cdd:cd19155 151 DQGLTRSIGLSNFNREQMARILKNAR----IKPANLQVELHVYLQQKDLVDFC---STHSITVTAYAPLGSPGAAHFSPG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 222 GNIPADSRFaldnyknlanrSLVDDTLrkvngLKPIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALDV 301
Cdd:cd19155 224 TGSPSGSSP-----------DLLQDPV-----VKAIAERHGKSPAQVLLRWLMQRGVV--VIPKSTNAARIKENFQVFDF 285
|
330 340
....*....|....*....|...
gi 925114528 302 ipLLTPEVVDRIEAVVQSKPKRT 324
Cdd:cd19155 286 --ELTEADMAKLSSLDKNIRGRT 306
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
10-213 |
8.58e-11 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 61.63 E-value: 8.58e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLfWggqg 89
Cdd:PRK11565 12 GNVMPQLGLGVW-----QASNEEVITAIHKALEVGYRSIDTAAIYKN---EEGVGKALKEASVAREELFITTKL-W---- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 90 pNDKglsRKHVVEGLRASLRRLDMDYVDVVYCHRPDAstPVEETVRAINWVID---QGWAFYWGTSEWSA---QQITEAW 163
Cdd:PRK11565 79 -NDD---HKRPREALEESLKKLQLDYVDLYLMHWPVP--AIDHYVEAWKGMIElqkEGLIKSIGVCNFQIhhlQRLIDET 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 925114528 164 AVAnrldlvgPIVEQPE-YNLFSRHKVESeflpLYSTYGIGLTTWSPLASG 213
Cdd:PRK11565 153 GVT-------PVINQIElHPLMQQRQLHA----WNATHKIQTESWSPLAQG 192
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
24-308 |
1.04e-10 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 61.70 E-value: 1.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 24 FGNQL-DVKEAKALLQACRDAGVNFFDNAEVYangRAEEIMGQAIRDL----GWRRSDVVISTKLFWGGQGPndkglsrK 98
Cdd:cd19129 11 FGTLIpDPSATRNAVKAALEAGFRHFDCAERY---RNEAEVGEAMQEVfkagKIRREDLFVTTKLWNTNHRP-------E 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 99 HVVEGLRASLRRLDMDYVDVVYCHRPDASTPVEE--------------------TVRAINWVIDQGWAFYWGTSEWSAQQ 158
Cdd:cd19129 81 RVKPAFEASLKRLQLDYLDLYLIHTPFAFQPGDEqdprdangnviyddgvtlldTWRAMERLVDEGRCKAIGLSDVSLEK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 159 ITEAWAVANrldlVGPIVEQPEYNLFSRhkvESEFLPLYSTYGIGLTTWSPLASGVLTGkytkgnipadsrfaldnyknl 238
Cdd:cd19129 161 LREIFEAAR----IKPAVVQVESHPYLP---EWELLDFCKNHGIVLQAFAPLGHGMEPK--------------------- 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 239 anrsLVDDTLrkvngLKPIAAELGVSLAQLSIAWCASNPnvSSVITGATKESQIVENmkaLDVIPLltPE 308
Cdd:cd19129 213 ----LLEDPV-----ITAIARRVNKTPAQVLLAWAIQRG--TALLTTSKTPSRIREN---FDISTL--PE 266
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
10-320 |
2.31e-10 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 60.37 E-value: 2.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGA------WVtFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANGraeeIMGQAIRD-LGWRRSDVVISTK 82
Cdd:PRK10376 14 GRSVNRLGYGAmqlagpGV-FGPPKDRDAAIAVLREAVALGVNHIDTSDFYGPH----VTNQLIREaLHPYPDDLTIVTK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 83 L--FWGGQGPNDKGLSRKHVVEGLRASLRRLDMDYVDVVY------CHRPdASTPVEETVRAINWVIDQGWAFYWGTSEW 154
Cdd:PRK10376 89 VgaRRGEDGSWLPAFSPAELRRAVHDNLRNLGLDVLDVVNlrlmgdGHGP-AEGSIEEPLTVLAELQRQGLVRHIGLSNV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 155 SAQQITEAWAVAnrldlvgPIV-EQPEYNLFSRHkvESEFLPLYSTYGIGLTTWSPLasgvltGKYTkgniPADSrfald 233
Cdd:PRK10376 168 TPTQVAEARKIA-------EIVcVQNHYNLAHRA--DDALIDALARDGIAYVPFFPL------GGFT----PLQS----- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 234 nyknlanrslvdDTLRKVnglkpiAAELGVSLAQLSIAWC-ASNPNVsSVITGATKESQIVENMKALDVIplLTPEVVDR 312
Cdd:PRK10376 224 ------------STLSDV------AASLGATPMQVALAWLlQRSPNI-LLIPGTSSVAHLRENLAAAELV--LSEEVLAE 282
|
....*...
gi 925114528 313 IEAVVQSK 320
Cdd:PRK10376 283 LDGIAREA 290
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
33-302 |
1.31e-09 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 58.51 E-value: 1.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 33 AKALLQACRDAGVNFFDNAEVYanGRAEEIMGQAIRDLGWRRSDVVISTKlfWG----------GQGPNDKGLSRKHVVE 102
Cdd:cd19098 37 THAVLDAAWAAGVRYFDAARSY--GRAEEFLGSWLRSRNIAPDAVFVGSK--WGytytadwqvdAAVHEVKDHSLARLLK 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 103 GLRASLRRLDmDYVDVVYCHRPDASTPV---EETVRAINWVIDQGWAFywGTSEWSAQQ---ITEAWAVA---NRL-DLV 172
Cdd:cd19098 113 QWEETRSLLG-KHLDLYQIHSATLESGVledADVLAALAELKAEGVKI--GLSLSGPQQaetLRRALEIEidgARLfDSV 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 173 gpiveQPEYNLFSRHKveSEFLPLYSTYGIGLTTWSPLASGVLTGkytkgnipadsrfaldnyknlANRSLVDDTLRKVn 252
Cdd:cd19098 190 -----QATWNLLEQSA--GEALEEAHEAGMGVIVKEALANGRLTD---------------------RNPSPELAPLMAV- 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 925114528 253 gLKPIAAELGVSLAQLSIAWCASNPNVSSVITGATKESQIVENMKALDVI 302
Cdd:cd19098 241 -LKAVADRLGVTPDALALAAVLAQPFVDVVLSGAATPEQLRSNLRALDVS 289
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
9-300 |
1.80e-09 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 57.74 E-value: 1.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDLG----WRRSDVVISTKLF 84
Cdd:cd19125 7 TGAKIPAVGLGTW-----QADPGVVGNAVKTAIKEGYRHIDCAAIYGN---EKEIGKALKKLFedgvVKREDLFITSKLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 85 WGGQGPNDkglsrkhVVEGLRASLRRLDMDYVDVVYCHRPDA--------------STPVEETVRAINWVIDQGWAFYWG 150
Cdd:cd19125 79 CTDHAPED-------VPPALEKTLKDLQLDYLDLYLIHWPVRlkkgahmpepeevlPPDIPSTWKAMEKLVDSGKVRAIG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 151 TSEWSAQQITEAWAVANrldlVGPIVEQPEYNLFSRHKvesEFLPLYSTYGIGLTTWSPLASGVLTgkYTKGNIpadsrf 230
Cdd:cd19125 152 VSNFSVKKLEDLLAVAR----VPPAVNQVECHPGWQQD---KLHEFCKSKGIHLSAYSPLGSPGTT--WVKKNV------ 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 231 aldnyknlanrsLVDDTLRKvnglkpIAAELGVSLAQLSIAWCASNPNvsSVITGATKESQIVENMKALD 300
Cdd:cd19125 217 ------------LKDPIVTK------VAEKLGKTPAQVALRWGLQRGT--SVLPKSTNEERIKENIDVFD 266
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
9-316 |
1.25e-07 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 52.45 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQ----AIRDLGWRRSDVVISTKLF 84
Cdd:cd19113 7 SGYKMPSVGFGCW-----KLDNATAADQIYQAIKAGYRLFDGAEDYGN---EKEVGEgvnrAIDEGLVKREELFLTSKLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 85 WGGQGPndkglsrKHVVEGLRASLRRLDMDYVDVVYCHRPDA-------------------------STPVEETVRAINW 139
Cdd:cd19113 79 NNFHDP-------KNVETALNKTLSDLKLDYVDLFLIHFPIAfkfvpieekyppgfycgdgdnfvyeDVPILDTWKALEK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 140 VIDQGWAFYWGTSEWSAQQIteawavanrLDL-----VGPIVEQPEYNLFSRHKVESEFLplySTYGIGLTTWSplasgv 214
Cdd:cd19113 152 LVDAGKIKSIGVSNFPGALI---------LDLlrgatIKPAVLQIEHHPYLQQPKLIEYA---QKAGITITAYS------ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 215 ltgkytkgNIPADSRFALDNyknlaNRSLVDDTLRKVNGLKPIAAELGVSLAQLSIAWcASNPNVsSVITGATKESQIVE 294
Cdd:cd19113 214 --------SFGPQSFVELNQ-----GRALNTPTLFEHDTIKSIAAKHNKTPAQVLLRW-ATQRGI-AVIPKSNLPERLLQ 278
|
330 340
....*....|....*....|..
gi 925114528 295 NMKALDVIplLTPEVVDRIEAV 316
Cdd:cd19113 279 NLSVNDFD--LTKEDFEEIAKL 298
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
10-226 |
1.69e-07 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 51.45 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 10 GLRVSQLSYGAWvtfgNQLDVKEAKALLQACrDAGVNFFDNAEVYANgraEEIMGQAIRDLGWRRSDVVISTKLFWGGQG 89
Cdd:cd19130 7 GNSIPQLGYGVF----KVPPADTQRAVATAL-EVGYRHIDTAAIYGN---EEGVGAAIAASGIPRDELFVTTKLWNDRHD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 90 PNDkglsrkhVVEGLRASLRRLDMDYVDVVYCHRPdasTPVE----ETVRAINWVIDQGWAFYWGTSEWSAQQITEAWAV 165
Cdd:cd19130 79 GDE-------PAAAFAESLAKLGLDQVDLYLVHWP---TPAAgnyvHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVAA 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 925114528 166 ANRLDLVGPIVEQPEY-NLFSRHKVESeflplystYGIGLTTWSPLASGVLTGKYTKGNIPA 226
Cdd:cd19130 149 TGVVPAVNQIELHPAYqQRTIRDWAQA--------HDVKIEAWSPLGQGKLLGDPPVGAIAA 202
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
9-129 |
1.92e-07 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 51.76 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDL---GWRRSDVVISTKLfW 85
Cdd:cd19121 8 TGASIPAVGLGTW-----QAKAGEVKAAVAHALKIGYRHIDGALCYQN---EDEVGEGIKEAiagGVKREDLFVTTKL-W 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 925114528 86 GGQGPNdkglsrkhVVEGLRASLRRLDMDYVDVVYCHRPDASTP 129
Cdd:cd19121 79 STYHRR--------VELCLDRSLKSLGLDYVDLYLVHWPVLLNP 114
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
9-300 |
1.76e-06 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 49.02 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWvtfgnQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIR---DLGW-RRSDVVISTKLf 84
Cdd:cd19112 7 SGHKMPVIGLGVW-----RMEPGEIKELILNAIKIGYRHFDCAADYKN---EKEVGEALAeafKTGLvKREDLFITTKL- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 85 WGgqgpNDKGlsrkHVVEGLRASLRRLDMDYVDVVYCHRP-----------------------DASTPVEETVRAINWVI 141
Cdd:cd19112 78 WN----SDHG----HVIEACKDSLKKLQLDYLDLYLVHFPvatkhtgvgttgsalgedgvldiDVTISLETTWHAMEKLV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 142 DQGWAFYWGTSEWSAQQITEAWAVANrldlVGPIVEQPE-YNLFSRHkvesEFLPLYSTYGIGLTTWSPLASGvltgkyt 220
Cdd:cd19112 150 SAGLVRSIGISNYDIFLTRDCLAYSK----IKPAVNQIEtHPYFQRD----SLVKFCQKHGISVTAHTPLGGA------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 221 kgnipadsrfaLDNYKNLANRSLVDDTLrkvngLKPIAAELGVSLAQLSIAWcaSNPNVSSVITGATKESQIVENMKALD 300
Cdd:cd19112 215 -----------AANAEWFGSVSPLDDPV-----LKDLAKKYGKSAAQIVLRW--GIQRNTAVIPKSSKPERLKENIDVFD 276
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
9-301 |
3.63e-06 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 47.62 E-value: 3.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGawvTFGNQLDVKEAKALLQACRDAGVNFFDNAEVYANgraEEIMGQAIRDL-----GWRRSDVVISTKL 83
Cdd:cd19122 5 NGVKIPAVGFG---TFANEGAKGETYAAVTKALDVGYRHLDCAWFYLN---EDEVGDAVRDFlkenpSVKREDLFICTKV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 84 FWGGQGPNDkglsrkhVVEGLRASLRRLDMDYVDVVYCHRP------DASTPV-----------------EETVRAINWV 140
Cdd:cd19122 79 WNHLHEPED-------VKWSIDNSLKNLKLDYIDLFLVHWPiaaeknDQRSPKlgpdgkyvilkdltenpEPTWRAMEEI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 141 IDQGWAFYWGTSEWSAQQITEAWAVANrldlVGPIVEQPEYNLFSRHKvesEFLPLYSTYGIGLTTWSPLASgvltgkyt 220
Cdd:cd19122 152 YESGKAKAIGVSNWTIPGLKKLLSFAK----VKPHVNQIEIHPFLPNE---ELVDYCFSNDILPEAYSPLGS-------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 221 KGNIPADSRFALDNyknlanrslvddtlrkvNGLKPIAAELGVSLAQLSIAWCASNPNVssVITGATKESQIVENMKALD 300
Cdd:cd19122 217 QNQVPSTGERVSEN-----------------PTLNEVAEKGGYSLAQVLIAWGLRRGYV--VLPKSSTPSRIESNFKSIE 277
|
.
gi 925114528 301 V 301
Cdd:cd19122 278 L 278
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
9-213 |
6.08e-06 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 47.11 E-value: 6.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWVTFGNQLDVKEAkalLQACRDAGVNFFDNAEVYAngrAEEIMGQAIRDL----GWRRSDVVISTKL- 83
Cdd:cd19119 8 TGASIPALGLGTASPHEDRAEVKEA---VEAAIKEGYRHIDTAYAYE---TEDFVGEAIKRAiddgSIKREELFITTKVw 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 84 --FWggqgpndkglsrKHVVEGLRASLRRLDMDYVDVVYCHRPDA-STPVEETVRAINWVIDQGWAFYWGTSEW--SAQQ 158
Cdd:cd19119 82 ptFY------------DEVERSLDESLKALGLDYVDLLLVHWPVCfEKDSDDSGKPFTPVNDDGKTRYAASGDHitTYKQ 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 925114528 159 ITE--------AWAVAN-------RLDLVGPIVeqPEYNLFSRHKV--ESEFLPLYSTYGIGLTTWSPLASG 213
Cdd:cd19119 150 LEKiyldgrakAIGVSNysivyleRLIKECKVV--PAVNQVELHPHlpQMDLRDFCFKHGILVTAYSPLGSH 219
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
42-132 |
7.85e-06 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 46.84 E-value: 7.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 42 DAGVNFFDNAEVYANgraEEIMGQAIR----DLGWRRSDVVISTKLFWGGQGPNdkgLSRKhvveGLRASLRRLDMDYVD 117
Cdd:cd19108 38 DAGFRHIDSAYLYQN---EEEVGQAIRskiaDGTVKREDIFYTSKLWCTFHRPE---LVRP----ALEKSLKKLQLDYVD 107
|
90
....*....|....*
gi 925114528 118 VVYCHRPDASTPVEE 132
Cdd:cd19108 108 LYLIHFPVALKPGEE 122
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
22-272 |
2.99e-04 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 41.77 E-value: 2.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 22 VTFGN-QLDVKEAKALLQACRDAGVNFFDNAEVYAN----GRAeeiMGQAIRDLGWRRSDVVISTKLfWggqgpnDKGLS 96
Cdd:cd19114 7 VGFGTaKIKANETEEVIYNAIKVGYRLIDGALLYGNeaevGRG---IRKAIQEGLVKREDLFIVTKL-W------NNFHG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 97 RKHVVEGLRASLRRLDMDYVDVVYCHRPDA-------------------------STPVEETVRAINWVIDQGWAFYWGT 151
Cdd:cd19114 77 KDHVREAFDRQLKDYGLDYIDLYLIHFPIPaayvdpaenypflwkdkelkkfpleQSPMQECWREMEKLVDAGLVRNIGI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 152 SEWSAQQITEAWAVANrldlVGPIVEQPEYNLFSRHKvesEFLPLYSTYGIGLTTWSPLASGVLTgKYTKGNipadsrfa 231
Cdd:cd19114 157 ANFNVQLILDLLTYAK----IKPAVLQIEHHPYLQQK---RLIDWAKKQGIQITAYSSFGNAVYT-KVTKHL-------- 220
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 925114528 232 ldnyKNLANrslvddtLRKVNGLKPIAAELGVSLAQLSIAW 272
Cdd:cd19114 221 ----KHFTN-------LLEHPVVKKLADKHKRDTGQVLLRW 250
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
9-315 |
9.70e-04 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 40.48 E-value: 9.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 9 SGLRVSQLSYGAWvtfgnqldvkeaKALLQACRD-------AGVNFFDNAEVYANGR-AEEIMGQAIRDLGWRRSDVVIS 80
Cdd:cd19115 9 SGYDMPLVGFGLW------------KVNNDTCADqvynaikAGYRLFDGACDYGNEVeAGQGVARAIKEGIVKREDLFIV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 81 TKLfWggQGPNDKglsrKHVVEGLRASLRRLDMDYVDVVYCHRPDA------------------------STPVEETVRA 136
Cdd:cd19115 77 SKL-W--NTFHDG----ERVEPICRKQLADWGIDYFDLFLIHFPIAlkyvdpavryppgwfydgkkvefsNAPIQETWTA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 137 INWVIDQGWAFYWGTSEWSAQQITEAWAVANrldlVGPIVEQPEYNLFsrhKVESEFLPLYSTYGIGLTtwsplasgvlt 216
Cdd:cd19115 150 MEKLVDKGLARSIGVSNFSAQLLMDLLRYAR----IRPATLQIEHHPY---LTQPRLVKYAQKEGIAVT----------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 217 gkytkgnipADSRFALDNYKNLANRSLVDDT-LRKVNGLKPIAAELGVSLAQLSIAWcASNPNVsSVITGATKESQIVEN 295
Cdd:cd19115 212 ---------AYSSFGPQSFLELDLPGAKDTPpLFEHDVIKSIAEKHGKTPAQVLLRW-ATQRGI-AVIPKSNNPKRLAQN 280
|
330 340
....*....|....*....|
gi 925114528 296 MKALDVIplLTPEVVDRIEA 315
Cdd:cd19115 281 LDVTGFD--LEAEEIKAISA 298
|
|
| PRK14863 |
PRK14863 |
bifunctional regulator KidO; Provisional |
32-124 |
4.05e-03 |
|
bifunctional regulator KidO; Provisional
Pssm-ID: 184865 [Multi-domain] Cd Length: 292 Bit Score: 38.36 E-value: 4.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 925114528 32 EAKALLQACRDAGVNFFDNAEVYanGRAEEIMGQAI-RDLGWRrsdVVISTklfwggqGPNDKGLSRkhvVEG-LRASLR 109
Cdd:PRK14863 33 EARDILNIAARAGLSVLDASGLF--GRAETVLGQLIpRPVPFR---VTLST-------VRADRGPDF---VEAeARASLR 97
|
90
....*....|....*
gi 925114528 110 RLDMDYVDVVYCHRP 124
Cdd:PRK14863 98 RMGVERADAILVHSP 112
|
|
| |
