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Conserved domains on  [gi|922845115|gb|ALA67435|]
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SAM-dependent methlyltransferase [Corynebacterium lactis RW2-5]

Protein Classification

tRNA (adenine-N1)-methyltransferase( domain architecture ID 11457537)

tRNA (adenine-N1)-methyltransferase, such as tRNA (adenine(58)-N(1))-methyltransferase, which is a class I SAM-dependent methyltransferase that catalyzes the methylation of N(1)-adenine at position 58 (m1A58) in tRNA using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 10-263 7.23e-137

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 386.05  E-value: 7.23e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  10 GDRVQLTDSKNRHFTVILEEGGKFFTHRGEILHDDLIGAHEGTTVTSGQGTVYLAQRHLLVDYILSMPRGAAVIYPKDAA 89
Cdd:COG2519    2 GDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  90 QIIVEGDIFPGARVLEAGAGSGALSLNLLRAIGPDGKLISYEVREDHIEHAERNVIDFMgaKPDNWDLRLGDLNEATEEs 169
Cdd:COG2519   82 YIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFG--LPDNVELKLGDIREGIDE- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115 170 lgGPVDRVILDMLAPWECLDTVSKVLQPGGVLMVYVATVPQLMKVMEGIREQKcYTEPRAWESLVRDWNVKDLSVRPAHR 249
Cdd:COG2519  159 --GDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG-FTDIEAVETLLREWKVEGLAVRPEHR 235

                        250
                 ....*....|....
gi 922845115 250 MQAHTAFLVWARRL 263
Cdd:COG2519  236 MVGHTGFLVFARKL 249
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 10-263 7.23e-137

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 386.05  E-value: 7.23e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  10 GDRVQLTDSKNRHFTVILEEGGKFFTHRGEILHDDLIGAHEGTTVTSGQGTVYLAQRHLLVDYILSMPRGAAVIYPKDAA 89
Cdd:COG2519    2 GDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  90 QIIVEGDIFPGARVLEAGAGSGALSLNLLRAIGPDGKLISYEVREDHIEHAERNVIDFMgaKPDNWDLRLGDLNEATEEs 169
Cdd:COG2519   82 YIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFG--LPDNVELKLGDIREGIDE- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115 170 lgGPVDRVILDMLAPWECLDTVSKVLQPGGVLMVYVATVPQLMKVMEGIREQKcYTEPRAWESLVRDWNVKDLSVRPAHR 249
Cdd:COG2519  159 --GDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG-FTDIEAVETLLREWKVEGLAVRPEHR 235

                        250
                 ....*....|....
gi 922845115 250 MQAHTAFLVWARRL 263
Cdd:COG2519  236 MVGHTGFLVFARKL 249
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 4-54 6.54e-26

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 96.41  E-value: 6.54e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 922845115    4 SGPFQVGDRVQLTDSKNRHFTVILEEGGKFFTHRGEILHDDLIGAHEGTTV 54
Cdd:pfam14801   1 RGPFRAGDRVQLTDPKGRKHTITLEPGGEFHTHRGAIRHDDLIGRPEGSVV 51
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 102-203 4.88e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.60  E-value: 4.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115 102 RVLEAGAGSGALSLNLlrAIGPDGKLISYEVREDHIEHAERNVIdfmGAKPDNWDLRLGDLNEATEESlGGPVDRVILDM 181
Cdd:cd02440    1 RVLDLGCGTGALALAL--ASGPGARVTGVDISPVALELARKAAA---ALLADNVEVLKGDAEELPPEA-DESFDVIISDP 74

                         90       100
                 ....*....|....*....|....*...
gi 922845115 182 LAPWEC------LDTVSKVLQPGGVLMV 203
Cdd:cd02440   75 PLHHLVedlarfLEEARRLLKPGGVLVL 102
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 96-223 1.93e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 41.54  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  96 DIFPGARVLEAGAGSGALSLNLLRAIGPDGKLISYEVREDHIEHAERNVIDfMGAkpDNWDLRLGDLNEATEESlgGPVD 175
Cdd:PRK13942  73 DLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK-LGY--DNVEVIVGDGTLGYEEN--APYD 147

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 922845115 176 RVILDMLAPwECLDTVSKVLQPGGVLMVYVATVPQ-LMKVME---GIREQKC 223
Cdd:PRK13942 148 RIYVTAAGP-DIPKPLIEQLKDGGIMVIPVGSYSQeLIRVEKdngKIIKKKL 198
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 10-263 7.23e-137

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 386.05  E-value: 7.23e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  10 GDRVQLTDSKNRHFTVILEEGGKFFTHRGEILHDDLIGAHEGTTVTSGQGTVYLAQRHLLVDYILSMPRGAAVIYPKDAA 89
Cdd:COG2519    2 GDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDAG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  90 QIIVEGDIFPGARVLEAGAGSGALSLNLLRAIGPDGKLISYEVREDHIEHAERNVIDFMgaKPDNWDLRLGDLNEATEEs 169
Cdd:COG2519   82 YIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFG--LPDNVELKLGDIREGIDE- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115 170 lgGPVDRVILDMLAPWECLDTVSKVLQPGGVLMVYVATVPQLMKVMEGIREQKcYTEPRAWESLVRDWNVKDLSVRPAHR 249
Cdd:COG2519  159 --GDVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESG-FTDIEAVETLLREWKVEGLAVRPEHR 235

                        250
                 ....*....|....
gi 922845115 250 MQAHTAFLVWARRL 263
Cdd:COG2519  236 MVGHTGFLVFARKL 249
GCD14_N pfam14801
tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, ...
 4-54 6.54e-26

tRNA methyltransferase complex GCD14 subunit N-term; This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.


Pssm-ID: 434222  Cd Length: 51  Bit Score: 96.41  E-value: 6.54e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 922845115    4 SGPFQVGDRVQLTDSKNRHFTVILEEGGKFFTHRGEILHDDLIGAHEGTTV 54
Cdd:pfam14801   1 RGPFRAGDRVQLTDPKGRKHTITLEPGGEFHTHRGAIRHDDLIGRPEGSVV 51
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 74-240 3.33e-19

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 84.08  E-value: 3.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115   74 LSMPRGAAVIYPKDAAQIIVEGDIFPGARVLEAGAGSGALSLNLLRAIGPDGKLISYEVredHIEHAERNVIDFMGAKPD 153
Cdd:pfam08704  15 LNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEF---HEQRADKAREEFREHGID 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  154 NW-DLRLGDL-NEATEESLGGPVDRVILDMLAPWECLDTVSKVLQ-PGGVLMVYVATVPQLMKVMEGIREQKcYTEPRAW 230
Cdd:pfam08704  92 QLvTVTHRDVcKEGFLTEVSGKADAVFLDLPSPWEAVPHAWKALKvEGGRFCSFSPCIEQVQRTCQALAELG-FTEISTL 170

                         170
                  ....*....|
gi 922845115  231 ESLVRDWNVK 240
Cdd:pfam08704 171 EVLLRVYDVR 180
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 102-203 4.88e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.60  E-value: 4.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115 102 RVLEAGAGSGALSLNLlrAIGPDGKLISYEVREDHIEHAERNVIdfmGAKPDNWDLRLGDLNEATEESlGGPVDRVILDM 181
Cdd:cd02440    1 RVLDLGCGTGALALAL--ASGPGARVTGVDISPVALELARKAAA---ALLADNVEVLKGDAEELPPEA-DESFDVIISDP 74

                         90       100
                 ....*....|....*....|....*...
gi 922845115 182 LAPWEC------LDTVSKVLQPGGVLMV 203
Cdd:cd02440   75 PLHHLVedlarfLEEARRLLKPGGVLVL 102
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 102-220 9.91e-10

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 56.35  E-value: 9.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115 102 RVLEAGAGSGALSLNLLRAIGPDGKLISYEVREDHIEHAERNVIDFmgAKPDNWDLRLGDLNEATEESLGGPVDRVILD- 180
Cdd:COG4122   19 RILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARA--GLADRIRLILGDALEVLPRLADGPFDLVFIDa 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 922845115 181 --MLAPwECLDTVSKVLQPGGVLMV-------YVATVPQLMKVMEGIRE 220
Cdd:COG4122   97 dkSNYP-DYLELALPLLRPGGLIVAdnvlwhgRVADPARRDPSTRAIRE 144
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 97-203 1.82e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.42  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115   97 IFPGARVLEAGAGSGALSLNLLRAIGPDGKLISYEVREDHIEHAERNVIDFmgaKPDNWDLRLGDLNEATEESLGGPVD- 175
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKL---GFDNVEFEQGDIEELPELLEDDKFDv 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 922845115  176 ----RVILDMLAPWECLDTVSKVLQPGGVLMV 203
Cdd:pfam13847  78 visnCVLNHIPDPDKVLQEILRVLKPGGRLII 109
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 99-220 2.29e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 49.22  E-value: 2.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  99 PGARVLEAGAGSGALSLNLLRAigpDGKLISYEVREDHIEHAERNVidfmGAKPDNWDLRLGDLneateESL---GGPVD 175
Cdd:COG2226   22 PGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERA----AEAGLNVEFVVGDA-----EDLpfpDGSFD 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 922845115 176 RVIL-----DMLAPWECLDTVSKVLQPGGVLMVYVATVPQLMKVMEGIRE 220
Cdd:COG2226   90 LVISsfvlhHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAE 139
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 99-206 6.90e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 48.00  E-value: 6.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  99 PGARVLEAGAGSGALSLNLLRAIGpdGKLISYEVREDHIEHAERNvIDFMGAkPDNWDLRLGDLNEATEEslgGPVDRVI 178
Cdd:COG2230   51 PGMRVLDIGCGWGGLALYLARRYG--VRVTGVTLSPEQLEYARER-AAEAGL-ADRVEVRLADYRDLPAD---GQFDAIV 123

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 922845115 179 -LDML-----APW-ECLDTVSKVLQPGGVLMVYVA 206
Cdd:COG2230  124 sIGMFehvgpENYpAYFAKVARLLKPGGRLLLHTP 158
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 99-278 7.15e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 48.76  E-value: 7.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  99 PGARVLEAGAGSGALSLNLLRAIGpdGKLISYEVREDHIEHAERNVIdfmGAKPDNWDLRLGDLNEATEESLgGPVDRVI 178
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAA---KAGLGNVEFLVADLAELDPLPA-ESFDLVV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115 179 LDMLAPW-------ECLDTVSKVLQPGGVLMVyVATVPQLMKVMEGireqkcyTEPRAWESLVRDWNVK-DLSVRPAHRM 250
Cdd:COG0500  100 AFGVLHHlppeereALLRELARALKPGGVLLL-SASDAAAALSLAR-------LLLLATASLLELLLLLrLLALELYLRA 171

                        170       180
                 ....*....|....*....|....*...
gi 922845115 251 QAHTAFLVWARRLADGTVPPRPQRRNQK 278
Cdd:COG0500  172 LLAAAATEDLRSDALLESANALEYLLSK 199
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
96-205 1.68e-06

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 47.75  E-value: 1.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115   96 DIFPGARVLEAGAGSGALSLNLLRAIGPDGKLISYEVREDHIEHAERNVidfMGAKPDNWDLRLGDLNEATEESlgGPVD 175
Cdd:pfam01135  70 ELKPGMRVLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNL---EKLGLENVIVVVGDGRQGWPEF--APYD 144

                          90       100       110
                  ....*....|....*....|....*....|
gi 922845115  176 RVILDMLAPwECLDTVSKVLQPGGVLMVYV 205
Cdd:pfam01135 145 AIHVGAAAP-EIPEALIDQLKEGGRLVIPV 173
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 92-203 5.64e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 44.62  E-value: 5.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  92 IVEGDIFPGARVLEAGAGSGALSLNLLRAigpdG-KLISYEVREDHIEHAERNvidfmgAKPDNWDLRLGDLNEATEEsl 170
Cdd:COG2227   17 LLARLLPAGGRVLDVGCGTGRLALALARR----GaDVTGVDISPEALEIARER------AAELNVDFVQGDLEDLPLE-- 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 922845115 171 GGPVDRVI-LDMLA----PWECLDTVSKVLQPGGVLMV 203
Cdd:COG2227   85 DGSFDLVIcSEVLEhlpdPAALLRELARLLKPGGLLLL 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 103-199 2.24e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 42.17  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  103 VLEAGAGSGALSLNLLRAIGpdGKLISYEVREDHIEHAERNVidfmGAKPDNWDLRLGDLNEATEESlgGPVDRVI---- 178
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERA----AEAGLNVEFVQGDAEDLPFPD--GSFDLVVssgv 72

                          90       100
                  ....*....|....*....|....
gi 922845115  179 ---LDMLAPWECLDTVSKVLQPGG 199
Cdd:pfam13649  73 lhhLPDPDLEAALREIARVLKPGG 96
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 104-201 1.21e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 40.43  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  104 LEAGAGSGALSLNLLRAIgPDGKLISYEVREDHIEHAERNVIDFMGAKPDNWDLRLGDLneatEESLGGPVD-----RVI 178
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL-PGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDL----GELDPGSFDvvvasNVL 75

                          90       100
                  ....*....|....*....|...
gi 922845115  179 LDMLAPWECLDTVSKVLQPGGVL 201
Cdd:pfam08242  76 HHLADPRAVLRNIRRLLKPGGVL 98
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 96-220 1.56e-04

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 42.85  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  96 DIFPGARVLEAGAGSGALSLNLLRAiGPDGKLISYEVREDHIEHAERNVIDFmGAkpDNWDLRLGDLNEATEEsLGGPvD 175
Cdd:COG2242  244 ALRPGDVLWDIGAGSGSVSIEAARL-APGGRVYAIERDPERAALIRANARRF-GV--PNVEVVEGEAPEALAD-LPDP-D 317

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 922845115 176 RVI-------LDMLapwecLDTVSKVLQPGGVLMVYVATVPQLMKVMEGIRE 220
Cdd:COG2242  318 AVFiggsggnLPEI-----LEACWARLRPGGRLVANAVTLETLALALEALAE 364
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 96-223 1.93e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 41.54  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  96 DIFPGARVLEAGAGSGALSLNLLRAIGPDGKLISYEVREDHIEHAERNVIDfMGAkpDNWDLRLGDLNEATEESlgGPVD 175
Cdd:PRK13942  73 DLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK-LGY--DNVEVIVGDGTLGYEEN--APYD 147

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 922845115 176 RVILDMLAPwECLDTVSKVLQPGGVLMVYVATVPQ-LMKVME---GIREQKC 223
Cdd:PRK13942 148 RIYVTAAGP-DIPKPLIEQLKDGGIMVIPVGSYSQeLIRVEKdngKIIKKKL 198
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
99-205 3.42e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 39.04  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  99 PGARVLEAGAGSGALSLNLLRAIgPDGKLISYEVREDHIEHAERNVidfmgakpDNWDLRLGDLNEATeesLGGPVDRVI 178
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERF-PGARVTGVDLSPEMLARARARL--------PNVRFVVADLRDLD---PPEPFDLVV 68

                         90       100       110
                 ....*....|....*....|....*....|..
gi 922845115 179 LDMLAPW-----ECLDTVSKVLQPGGVLMVYV 205
Cdd:COG4106   69 SNAALHWlpdhaALLARLAAALAPGGVLAVQV 100
PRK14968 PRK14968
putative methyltransferase; Provisional
 89-204 1.05e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 39.11  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  89 AQIIVEGdifPGARVLEAGAGSGALSLNLLRAigpDGKLISYEVREDHIEHAERN------------VID---FMGAKPD 153
Cdd:PRK14968  16 AENAVDK---KGDRVLEVGTGSGIVAIVAAKN---GKKVVGVDINPYAVECAKCNaklnnirnngveVIRsdlFEPFRGD 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 922845115 154 NWDLRL-------GDLNEATEESL-----GGPVDRVILDMLapwecLDTVSKVLQPGG-VLMVY 204
Cdd:PRK14968  90 KFDVILfnppylpTEEEEEWDDWLnyalsGGKDGREVIDRF-----LDEVGRYLKPGGrILLLQ 148
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 99-178 1.51e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 38.97  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  99 PGARVLEAGAGSGALSLnLLRAIGPDGKLISYEVREDHIEHAERNVIDfmgakpDNWDLRL----GDLNEATEESLGGPV 174
Cdd:COG4123   37 KGGRVLDLGTGTGVIAL-MLAQRSPGARITGVEIQPEAAELARRNVAL------NGLEDRItvihGDLKEFAAELPPGSF 109


                 ....
gi 922845115 175 DRVI 178
Cdd:COG4123  110 DLVV 113
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
88-178 1.57e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 38.73  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  88 AAQIIVE----GDIfPGARVLEAGAGSGALSLNLLRAiGPDgKLISYEVREDHIEHAERNVIDFMGakpdNWDLRLGDln 163
Cdd:COG2263   31 AAELLHLaylrGDI-EGKTVLDLGCGTGMLAIGAALL-GAK-KVVGVDIDPEALEIARENAERLGV----RVDFIRAD-- 101

                         90
                 ....*....|....*
gi 922845115 164 eATEESLGGPVDRVI 178
Cdd:COG2263  102 -VTRIPLGGSVDTVV 115
PRK08317 PRK08317
hypothetical protein; Provisional
 96-199 6.09e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 37.22  E-value: 6.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115  96 DIFPGARVLEAGAGSGALSLNLLRAIGPDGKLISYEVREDHIEHAERNVidfmGAKPDNWDLRLGDlneatEESLG---G 172
Cdd:PRK08317  16 AVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERA----AGLGPNVEFVRGD-----ADGLPfpdG 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 922845115 173 PVDRVILDMLApwECLDTVSK-------VLQPGG 199
Cdd:PRK08317  87 SFDAVRSDRVL--QHLEDPARalaeiarVLRPGG 118
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
102-216 6.21e-03

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 36.73  E-value: 6.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922845115 102 RVLEAGAGSGALSLNLLRAIGPDGKLISYEVREDHIEHAER-----NVIDfMGAkpdnwdlrlGDLNEATEESLGGPVDR 176
Cdd:COG3963   48 PVVELGPGTGVFTRAILARGVPDARLLAVEINPEFAEHLRRrfprvTVVN-GDA---------EDLAELLAEHGIGKVDA 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 922845115 177 VI--LdmlaPW---------ECLDTVSKVLQPGGVLMV--YVATVPQLMKVME 216
Cdd:COG3963  118 VVsgL----PLlsfppelrrAILDAAFRVLAPGGVFVQftYSPRSPVPRKLLR 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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