NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|922368331|ref|XP_013456330|]
View 

AUGMIN subunit 2 [Medicago truncatula]

Protein Classification

HAUS2 domain-containing protein( domain architecture ID 10633208)

HAUS2 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HAUS2 pfam15003
HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins ...
 19-212 4.61e-94

HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 291 amino acids in length. HAUS augmin-like complex subunit 2 is alternatively called centrosomal protein of 27 kDa (CEP27). It localized in the microtubule organizing centre, the centrosome. These microtubules are part of the cytoskeleton and give the cell its shape, provides it with a platform for motility and are crucial for mitosis. This protein is part of the HAUS augmin-like complex. This interacts with the gamma-tubulin ring complex (gamma-TuRC) which is required for spindle generation. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis. This protein is involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis.


:

Pssm-ID: 373465  Cd Length: 191  Bit Score: 274.45  E-value: 4.61e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922368331   19 GGMSDALSIAADLGFSVSSPSssTHESLHNPPTTSTgEKGEDLIRVLRELTSVQRKIADLQVELQGRKDDKNVAHLTHVS 98
Cdd:pfam15003   1 GGLADALSLALLLGHFVASGD--VHDEVQNLAKKSA-FKNDALISRLRELSNVQRELAQLNLELQGRKDDKDTADLTHVS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922368331   99 EMEKKIETLDRITTILKDVIHNKDRIIARLQQPYSLDCIPVEAEYQKQFSELLMKAASDYGALTASVADFQWSQNFKEPP 178
Cdd:pfam15003  78 EIEKKCEALQRMTTHLKAVIQNKDRIIARLQQPYSLDCLPIEAEYHRQFSELLPKAASDYGALTAHLSDFQWSQSFKNPP 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 922368331  179 SVWGEMLRPIPVALASCTRYFEAMSAKRESFAAL 212
Cdd:pfam15003 158 SLWDENLRPIPVALASCTRLFEATEAMRENIAKW 191
 
Name Accession Description Interval E-value
HAUS2 pfam15003
HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins ...
 19-212 4.61e-94

HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 291 amino acids in length. HAUS augmin-like complex subunit 2 is alternatively called centrosomal protein of 27 kDa (CEP27). It localized in the microtubule organizing centre, the centrosome. These microtubules are part of the cytoskeleton and give the cell its shape, provides it with a platform for motility and are crucial for mitosis. This protein is part of the HAUS augmin-like complex. This interacts with the gamma-tubulin ring complex (gamma-TuRC) which is required for spindle generation. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis. This protein is involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis.


Pssm-ID: 373465  Cd Length: 191  Bit Score: 274.45  E-value: 4.61e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922368331   19 GGMSDALSIAADLGFSVSSPSssTHESLHNPPTTSTgEKGEDLIRVLRELTSVQRKIADLQVELQGRKDDKNVAHLTHVS 98
Cdd:pfam15003   1 GGLADALSLALLLGHFVASGD--VHDEVQNLAKKSA-FKNDALISRLRELSNVQRELAQLNLELQGRKDDKDTADLTHVS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922368331   99 EMEKKIETLDRITTILKDVIHNKDRIIARLQQPYSLDCIPVEAEYQKQFSELLMKAASDYGALTASVADFQWSQNFKEPP 178
Cdd:pfam15003  78 EIEKKCEALQRMTTHLKAVIQNKDRIIARLQQPYSLDCLPIEAEYHRQFSELLPKAASDYGALTAHLSDFQWSQSFKNPP 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 922368331  179 SVWGEMLRPIPVALASCTRYFEAMSAKRESFAAL 212
Cdd:pfam15003 158 SLWDENLRPIPVALASCTRLFEATEAMRENIAKW 191
 
Name Accession Description Interval E-value
HAUS2 pfam15003
HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins ...
 19-212 4.61e-94

HAUS augmin-like complex subunit 2; This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 291 amino acids in length. HAUS augmin-like complex subunit 2 is alternatively called centrosomal protein of 27 kDa (CEP27). It localized in the microtubule organizing centre, the centrosome. These microtubules are part of the cytoskeleton and give the cell its shape, provides it with a platform for motility and are crucial for mitosis. This protein is part of the HAUS augmin-like complex. This interacts with the gamma-tubulin ring complex (gamma-TuRC) which is required for spindle generation. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis. This protein is involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis.


Pssm-ID: 373465  Cd Length: 191  Bit Score: 274.45  E-value: 4.61e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922368331   19 GGMSDALSIAADLGFSVSSPSssTHESLHNPPTTSTgEKGEDLIRVLRELTSVQRKIADLQVELQGRKDDKNVAHLTHVS 98
Cdd:pfam15003   1 GGLADALSLALLLGHFVASGD--VHDEVQNLAKKSA-FKNDALISRLRELSNVQRELAQLNLELQGRKDDKDTADLTHVS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922368331   99 EMEKKIETLDRITTILKDVIHNKDRIIARLQQPYSLDCIPVEAEYQKQFSELLMKAASDYGALTASVADFQWSQNFKEPP 178
Cdd:pfam15003  78 EIEKKCEALQRMTTHLKAVIQNKDRIIARLQQPYSLDCLPIEAEYHRQFSELLPKAASDYGALTAHLSDFQWSQSFKNPP 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 922368331  179 SVWGEMLRPIPVALASCTRYFEAMSAKRESFAAL 212
Cdd:pfam15003 158 SLWDENLRPIPVALASCTRLFEATEAMRENIAKW 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH