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Conserved domains on  [gi|922337531|ref|XP_013446755|]
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homeobox-leucine zipper protein ATHB-6 [Medicago truncatula]

Protein Classification

homeobox-leucine zipper protein( domain architecture ID 11079011)

homeobox-leucine zipper protein is a transcription factor that may function in plant development and/or in stress adaptation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
54-107 3.15e-17

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 74.07  E-value: 3.15e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 922337531   54 KKRR--LSVDQVKALEKNFEVENKLEPDRKVKLAQELGLQPRQVAVWFQNRRARWK 107
Cdd:pfam00046   1 RRKRttFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HALZ pfam02183
Homeobox associated leucine zipper;
109-150 1.53e-14

Homeobox associated leucine zipper;


:

Pssm-ID: 460477 [Multi-domain]  Cd Length: 42  Bit Score: 66.39  E-value: 1.53e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 922337531  109 KQLERDYGVLKANYDALKLNCEDLQRDKETLLKEVKELKSRL 150
Cdd:pfam02183   1 KQLERDYDVLKASYDALKSDFDSLKKENQKLQAELQELKEKL 42
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
54-107 3.15e-17

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 74.07  E-value: 3.15e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 922337531   54 KKRR--LSVDQVKALEKNFEVENKLEPDRKVKLAQELGLQPRQVAVWFQNRRARWK 107
Cdd:pfam00046   1 RRKRttFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 54-107 2.43e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 71.90  E-value: 2.43e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 922337531    54 KKRRLSVDQVKALEKNFEVENKLEPDRKVKLAQELGLQPRQVAVWFQNRRARWK 107
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 53-110 9.09e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 70.35  E-value: 9.09e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 922337531  53 QKKRRLSVDQVKALEKNFEVENKLEPDRKVKLAQELGLQPRQVAVWFQNRRARWKTKQ 110
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HALZ pfam02183
Homeobox associated leucine zipper;
109-150 1.53e-14

Homeobox associated leucine zipper;


Pssm-ID: 460477 [Multi-domain]  Cd Length: 42  Bit Score: 66.39  E-value: 1.53e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 922337531  109 KQLERDYGVLKANYDALKLNCEDLQRDKETLLKEVKELKSRL 150
Cdd:pfam02183   1 KQLERDYDVLKASYDALKSDFDSLKKENQKLQAELQELKEKL 42
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
16-110 1.81e-09

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.52  E-value: 1.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922337531  16 ICPTTEEESPRNNqvyGREFQSMMEGLDEEGCVDE---PGQKKRRLSVDQVKALEKNFEVENKLEPDRKVKLAQELGLQP 92
Cdd:COG5576   16 RMPQIRTIKTTKN---KREVEAADSEMKLERKQDGsspPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPP 92

                         90
                 ....*....|....*...
gi 922337531  93 RQVAVWFQNRRARWKTKQ 110
Cdd:COG5576   93 KSVQIWFQNKRAKEKKKR 110
ZIP_MycBP-like cd21937
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called ...
 120-154 2.21e-03

leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. This model corresponds to the conserved region that shows high sequence similarity with the leucine zipper (ZIP) domain located at the C-terminus of TGF-beta-stimulated clone-22 domain (TSC22D) family transcription factors. The first helix of ZIP is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409277 [Multi-domain]  Cd Length: 53  Bit Score: 35.60  E-value: 2.21e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 922337531 120 ANYDALKLNCEDLQRDKETLLKEVKELKSRLQIQE 154
Cdd:cd21937   19 ADVEALRLENEELKQKNEELEEENKELKAKLQQYE 53
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
54-107 3.15e-17

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 74.07  E-value: 3.15e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 922337531   54 KKRR--LSVDQVKALEKNFEVENKLEPDRKVKLAQELGLQPRQVAVWFQNRRARWK 107
Cdd:pfam00046   1 RRKRttFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 54-107 2.43e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 71.90  E-value: 2.43e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 922337531    54 KKRRLSVDQVKALEKNFEVENKLEPDRKVKLAQELGLQPRQVAVWFQNRRARWK 107
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 53-110 9.09e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 70.35  E-value: 9.09e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 922337531  53 QKKRRLSVDQVKALEKNFEVENKLEPDRKVKLAQELGLQPRQVAVWFQNRRARWKTKQ 110
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HALZ pfam02183
Homeobox associated leucine zipper;
109-150 1.53e-14

Homeobox associated leucine zipper;


Pssm-ID: 460477 [Multi-domain]  Cd Length: 42  Bit Score: 66.39  E-value: 1.53e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 922337531  109 KQLERDYGVLKANYDALKLNCEDLQRDKETLLKEVKELKSRL 150
Cdd:pfam02183   1 KQLERDYDVLKASYDALKSDFDSLKKENQKLQAELQELKEKL 42
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
16-110 1.81e-09

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.52  E-value: 1.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922337531  16 ICPTTEEESPRNNqvyGREFQSMMEGLDEEGCVDE---PGQKKRRLSVDQVKALEKNFEVENKLEPDRKVKLAQELGLQP 92
Cdd:COG5576   16 RMPQIRTIKTTKN---KREVEAADSEMKLERKQDGsspPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPP 92

                         90
                 ....*....|....*...
gi 922337531  93 RQVAVWFQNRRARWKTKQ 110
Cdd:COG5576   93 KSVQIWFQNKRAKEKKKR 110
ZIP_MycBP-like cd21937
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called ...
 120-154 2.21e-03

leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. This model corresponds to the conserved region that shows high sequence similarity with the leucine zipper (ZIP) domain located at the C-terminus of TGF-beta-stimulated clone-22 domain (TSC22D) family transcription factors. The first helix of ZIP is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409277 [Multi-domain]  Cd Length: 53  Bit Score: 35.60  E-value: 2.21e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 922337531 120 ANYDALKLNCEDLQRDKETLLKEVKELKSRLQIQE 154
Cdd:cd21937   19 ADVEALRLENEELKQKNEELEEENKELKAKLQQYE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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