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Conserved domains on  [gi|922080159|gb|ALA55687|]
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tumor supressor p53, partial [Lasiopodomys gregalis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P53 super family cl14608
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ...
 1-104 3.07e-46

P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes.


The actual alignment was detected with superfamily member cd08367:

Pssm-ID: 472693  Cd Length: 179  Bit Score: 146.26  E-value: 3.07e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922080159   1 PVQLWVSSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGdGLAPPQHLIRVEgNLRAEYLDDRQTFRHSVVVPYE 80
Cdd:cd08367   34 PIQFKVNPSPPPGLYVRAMLVYKDPEHVKEPVERCPNHRQGDDG-HTAPNSHVIRCE-NPQAEYVGDAFTGRLSVVVPLE 111

                         90       100
                 ....*....|....*....|....
gi 922080159  81 PPEVGSDCTTIHYNYMCNSSCMGG 104
Cdd:cd08367  112 PPQVGSEYVTVLLQFMCQNSCPGG 135
 
Name Accession Description Interval E-value
P53 cd08367
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ...
 1-104 3.07e-46

P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes.


Pssm-ID: 176262  Cd Length: 179  Bit Score: 146.26  E-value: 3.07e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922080159   1 PVQLWVSSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGdGLAPPQHLIRVEgNLRAEYLDDRQTFRHSVVVPYE 80
Cdd:cd08367   34 PIQFKVNPSPPPGLYVRAMLVYKDPEHVKEPVERCPNHRQGDDG-HTAPNSHVIRCE-NPQAEYVGDAFTGRLSVVVPLE 111

                         90       100
                 ....*....|....*....|....
gi 922080159  81 PPEVGSDCTTIHYNYMCNSSCMGG 104
Cdd:cd08367  112 PPQVGSEYVTVLLQFMCQNSCPGG 135
P53 pfam00870
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ...
 1-104 5.98e-38

P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.


Pssm-ID: 459972 [Multi-domain]  Cd Length: 191  Bit Score: 125.86  E-value: 5.98e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922080159    1 PVQLWVSSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEgNLRAEYL-DDRQTFRHSVVVPY 79
Cdd:pfam00870  44 PFNFKTDPPPPPGLYIRAMLVYSKSEHANDPVERCPNHRAKDDGNNDPIREHVIRCE-NPDAEYVgTDEGDERLSVVVPL 122

                          90       100
                  ....*....|....*....|....*
gi 922080159   80 EPPEVGSDCTTIHYNYMCNSSCMGG 104
Cdd:pfam00870 123 EHPQAGSESVTLLLKFMCKSSCPGG 147
 
Name Accession Description Interval E-value
P53 cd08367
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ...
 1-104 3.07e-46

P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes.


Pssm-ID: 176262  Cd Length: 179  Bit Score: 146.26  E-value: 3.07e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922080159   1 PVQLWVSSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGdGLAPPQHLIRVEgNLRAEYLDDRQTFRHSVVVPYE 80
Cdd:cd08367   34 PIQFKVNPSPPPGLYVRAMLVYKDPEHVKEPVERCPNHRQGDDG-HTAPNSHVIRCE-NPQAEYVGDAFTGRLSVVVPLE 111

                         90       100
                 ....*....|....*....|....
gi 922080159  81 PPEVGSDCTTIHYNYMCNSSCMGG 104
Cdd:cd08367  112 PPQVGSEYVTVLLQFMCQNSCPGG 135
P53 pfam00870
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ...
 1-104 5.98e-38

P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.


Pssm-ID: 459972 [Multi-domain]  Cd Length: 191  Bit Score: 125.86  E-value: 5.98e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922080159    1 PVQLWVSSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEgNLRAEYL-DDRQTFRHSVVVPY 79
Cdd:pfam00870  44 PFNFKTDPPPPPGLYIRAMLVYSKSEHANDPVERCPNHRAKDDGNNDPIREHVIRCE-NPDAEYVgTDEGDERLSVVVPL 122

                          90       100
                  ....*....|....*....|....*
gi 922080159   80 EPPEVGSDCTTIHYNYMCNSSCMGG 104
Cdd:pfam00870 123 EHPQAGSESVTLLLKFMCKSSCPGG 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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