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Conserved domains on  [gi|920223585|emb|CTQ94876|]
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hypothetical protein [Kibdelosporangium sp. MJ126-NF4]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4976 super family cl34853
Predicted methyltransferase, contains TPR repeat [General function prediction only];
37-111 1.80e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


The actual alignment was detected with superfamily member COG4976:

Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 51.92  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920223585  37 DEMLLAHCSGPT---LDIGCGPGRLTSALANRAVPVLGVDVSPVAVALTLARGAVA--LRRDVFDPLPGERRWHSVLLAD 111
Cdd:COG4976   36 EELLARLPPGPFgrvLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDrlLVADLADLAEPDGRFDLIVAAD 115
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
37-111 1.80e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 51.92  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920223585  37 DEMLLAHCSGPT---LDIGCGPGRLTSALANRAVPVLGVDVSPVAVALTLARGAVA--LRRDVFDPLPGERRWHSVLLAD 111
Cdd:COG4976   36 EELLARLPPGPFgrvLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDrlLVADLADLAEPDGRFDLIVAAD 115
PRK14968 PRK14968
putative methyltransferase; Provisional
 34-102 9.78e-07

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 47.20  E-value: 9.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920223585  34 EPSD------EMLLAHCSGPTLDIGCGPGRLTSALANRAVPVLGVDVSPVAVALTL---------ARGAVALRRDVFDPL 98
Cdd:PRK14968   7 EPAEdsfllaENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKcnaklnnirNNGVEVIRSDLFEPF 86


                 ....
gi 920223585  99 PGER 102
Cdd:PRK14968  87 RGDK 90
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 49-87 3.89e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 43.71  E-value: 3.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 920223585   49 LDIGCGPGRLTSALANRA-VPVLGVDVSPVAVALTLARGA 87
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGgARVTGVDLSPEMLERARERAA 41
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 49-94 2.63e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.95  E-value: 2.63e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 920223585  49 LDIGCGPGRLTSALANR-AVPVLGVDVSPVAVALTLARGAVALRRDV 94
Cdd:cd02440    3 LDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADNV 49
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
37-111 1.80e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 51.92  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920223585  37 DEMLLAHCSGPT---LDIGCGPGRLTSALANRAVPVLGVDVSPVAVALTLARGAVA--LRRDVFDPLPGERRWHSVLLAD 111
Cdd:COG4976   36 EELLARLPPGPFgrvLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDrlLVADLADLAEPDGRFDLIVAAD 115
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 49-87 3.08e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 47.32  E-value: 3.08e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 920223585  49 LDIGCGPGRLTSALANRAVPVLGVDVSPVAVALTLARGA 87
Cdd:COG2227   29 LDVGCGTGRLALALARRGADVTGVDISPEALEIARERAA 67
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
49-102 4.20e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 46.36  E-value: 4.20e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 920223585  49 LDIGCGPGRLTSALANR--AVPVLGVDVSPVAVALTLAR--GAVALRRDVFDPLPGER 102
Cdd:COG4106    6 LDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARlpNVRFVVADLRDLDPPEP 63
PRK14968 PRK14968
putative methyltransferase; Provisional
 34-102 9.78e-07

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 47.20  E-value: 9.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920223585  34 EPSD------EMLLAHCSGPTLDIGCGPGRLTSALANRAVPVLGVDVSPVAVALTL---------ARGAVALRRDVFDPL 98
Cdd:PRK14968   7 EPAEdsfllaENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKcnaklnnirNNGVEVIRSDLFEPF 86


                 ....
gi 920223585  99 PGER 102
Cdd:PRK14968  87 RGDK 90
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 49-87 3.89e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 43.71  E-value: 3.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 920223585   49 LDIGCGPGRLTSALANRA-VPVLGVDVSPVAVALTLARGA 87
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGgARVTGVDLSPEMLERARERAA 41
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 49-87 4.46e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 44.60  E-value: 4.46e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 920223585  49 LDIGCGPGRLTSALANRAVPVLGVDVSPVAVALTLARGA 87
Cdd:COG2226   27 LDLGCGTGRLALALAERGARVTGVDISPEMLELARERAA 65
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 45-81 5.61e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 45.29  E-value: 5.61e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 920223585  45 SGPTLDIGCGPGRLTSALANRAV-PVLGVDVSPVAVAL 81
Cdd:COG0500   27 GGRVLDLGCGTGRNLLALAARFGgRVIGIDLSPEAIAL 64
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-86 1.08e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 42.27  E-value: 1.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 920223585   49 LDIGCGPGRLTSALANRAVPVLGVDVSPVAVALTLARG 86
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKA 38
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 38-102 3.36e-05

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 42.87  E-value: 3.36e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 920223585  38 EMLLAHCSGPT----LDIGCGPGRLTSALANRAvP---VLGVDVSPVAVALTLA-------RGAVALRRDVFDPLPGER 102
Cdd:COG2813   39 RLLLEHLPEPLggrvLDLGCGYGVIGLALAKRN-PearVTLVDVNARAVELARAnaaanglENVEVLWSDGLSGVPDGS 116
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 49-89 1.85e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 40.30  E-value: 1.85e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 920223585  49 LDIGCGPGRLTSALANRA-VPVLGVDVSPVAVALTLARGAVA 89
Cdd:COG2230   56 LDIGCGWGGLALYLARRYgVRVTGVTLSPEQLEYARERAAEA 97
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 49-94 2.63e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.95  E-value: 2.63e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 920223585  49 LDIGCGPGRLTSALANR-AVPVLGVDVSPVAVALTLARGAVALRRDV 94
Cdd:cd02440    3 LDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADNV 49
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 49-98 4.49e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 38.12  E-value: 4.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 920223585   49 LDIGCGPGRLTSALANRAVP--VLGVDVSPVAVALTLARGAvALRRDVFDPL 98
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGleYTGLDISPAALEAARERLA-ALGLLNAVRV 51
PRK08317 PRK08317
hypothetical protein; Provisional
 49-99 6.02e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.53  E-value: 6.02e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 920223585  49 LDIGCGPGRLTSALANRAVP---VLGVDVSPVAVALTLARGA-----VALRRDVFDPLP 99
Cdd:PRK08317  24 LDVGCGPGNDARELARRVGPegrVVGIDRSEAMLALAKERAAglgpnVEFVRGDADGLP 82
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 25-79 1.26e-03

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 38.74  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920223585  25 LPVQRWRATEPSD--EMLLA------------------------HCSGPT--LDIGCGPGRLTSALAN-----RAVPVLG 71
Cdd:PRK11088  38 LPVQHKRSKDPGDnkEMMQArrafldaghyqplrdavanllaerLDEKATalLDIGCGEGYYTHALADalpeiTTMQLFG 117


                 ....*...
gi 920223585  72 VDVSPVAV 79
Cdd:PRK11088 118 LDISKVAI 125
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 49-102 1.77e-03

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 38.22  E-value: 1.77e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 920223585  49 LDIGCGPGRLTSALAnRAVP---VLGVDVSPVAVALT-------LARGAVALRRDVFDPLPGER 102
Cdd:PRK09328 113 LDLGTGSGAIALALA-KERPdaeVTAVDISPEALAVArrnakhgLGARVEFLQGDWFEPLPGGR 175
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 6-102 2.79e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.80  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920223585    6 LALRGAECWLELANGTRVQLPVqrwratepsdemLLAHCSGPTLDIGCGPGRLTSALANRA--VPVLGVDVSPVAVAL-- 81
Cdd:pfam05175   5 KTLPGVFSHGRLDIGSRLLLEH------------LPKDLSGKVLDLGCGAGVLGAALAKESpdAELTMVDINARALESar 72

                          90       100
                  ....*....|....*....|....*.
gi 920223585   82 -TLAR----GAVALRRDVFDPLPGER 102
Cdd:pfam05175  73 eNLAAngleNGEVVASDVYSGVEDGK 98
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 49-79 3.62e-03

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 36.63  E-value: 3.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 920223585   49 LDIGCGPGRLTSALANRAVP---VLGVDVSPVAV 79
Cdd:pfam13847   8 LDLGCGTGHLSFELAEELGPnaeVVGIDISEEAI 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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