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Conserved domains on  [gi|919436017|gb|ALA19586|]
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patatin [Chelatococcus sp. CO-6]

Protein Classification

patatin-like phospholipase family protein( domain architecture ID 11448329)

patatin-like phospholipase family protein may catalyze the hydrolysis of lipids/phospholipids

CATH:  3.40.1090.10
EC:  3.1.1.-
Gene Ontology:  GO:0052689
PubMed:  11080672
SCOP:  3001121

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RssA COG1752
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function ...
 4-324 7.31e-66

Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only];


:

Pssm-ID: 441358 [Multi-domain]  Cd Length: 261  Bit Score: 208.60  E-value: 7.31e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017   4 PKAEKSICLALQGGGAHGAFTWGVVDALLEDGrLAIEAISGTSAGAMNAVVMTQGFieagidgARRDLETFWRRVSRDGA 83
Cdd:COG1752    1 APARPKIGLVLSGGGARGAAHIGVLKALEEAG-IPPDVIAGTSAGAIVGALYAAGY-------SADELEELWRSLDRRDL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  84 LSPLqrslVDRMLGIWGGGDEPPGLLwfdmvsrfaspydfnplNINPLRDLIEELI---DFDKVRacnsVSLFIAATNVR 160
Cdd:COG1752   73 FDLS----LPRRLLRLDLGLSPGGLL-----------------DGDPLRRLLERLLgdrDFEDLP----IPLAVVATDLE 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 161 TGKIKLFERPELtADHIMASACLPMVFQAVEIDGVPYWDGGYMGNPALFPLFYGAAsDDVLLVQINPIEREetPRSAREI 240
Cdd:COG1752  128 TGREVVFDSGPL-ADAVRASAAIPGVFPPVEIDGRLYVDGGVVNNLPVDPARALGA-DRVIAVDLNPPLRK--LPSLLDI 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 241 QNRLTEITFNATLLREMrAIEFVTRLIDEgklskdeykrvlmhridadllmkRVTAASRLsaDWSLLQRLADLGRQAARK 320
Cdd:COG1752  204 LGRALEIMFNSILRREL-ALEPADILIEP-----------------------DLSGISLL--DFSRAEELIEAGYEAARR 257


                 ....
gi 919436017 321 WLKE 324
Cdd:COG1752  258 ALDE 261
 
Name Accession Description Interval E-value
RssA COG1752
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function ...
 4-324 7.31e-66

Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only];


Pssm-ID: 441358 [Multi-domain]  Cd Length: 261  Bit Score: 208.60  E-value: 7.31e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017   4 PKAEKSICLALQGGGAHGAFTWGVVDALLEDGrLAIEAISGTSAGAMNAVVMTQGFieagidgARRDLETFWRRVSRDGA 83
Cdd:COG1752    1 APARPKIGLVLSGGGARGAAHIGVLKALEEAG-IPPDVIAGTSAGAIVGALYAAGY-------SADELEELWRSLDRRDL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  84 LSPLqrslVDRMLGIWGGGDEPPGLLwfdmvsrfaspydfnplNINPLRDLIEELI---DFDKVRacnsVSLFIAATNVR 160
Cdd:COG1752   73 FDLS----LPRRLLRLDLGLSPGGLL-----------------DGDPLRRLLERLLgdrDFEDLP----IPLAVVATDLE 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 161 TGKIKLFERPELtADHIMASACLPMVFQAVEIDGVPYWDGGYMGNPALFPLFYGAAsDDVLLVQINPIEREetPRSAREI 240
Cdd:COG1752  128 TGREVVFDSGPL-ADAVRASAAIPGVFPPVEIDGRLYVDGGVVNNLPVDPARALGA-DRVIAVDLNPPLRK--LPSLLDI 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 241 QNRLTEITFNATLLREMrAIEFVTRLIDEgklskdeykrvlmhridadllmkRVTAASRLsaDWSLLQRLADLGRQAARK 320
Cdd:COG1752  204 LGRALEIMFNSILRREL-ALEPADILIEP-----------------------DLSGISLL--DFSRAEELIEAGYEAARR 257


                 ....
gi 919436017 321 WLKE 324
Cdd:COG1752  258 ALDE 261
Pat_hypo_Ecoli_Z1214_like cd07209
Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase ...
 12-270 1.64e-35

Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.


Pssm-ID: 132848 [Multi-domain]  Cd Length: 215  Bit Score: 128.56  E-value: 1.64e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  12 LALQGGGAHGAFTWGVVDALLEDGrLAIEAISGTSAGAMNAVVMTQGfieaGIDGARRdLETFWRRVSRDGALsplqrsl 91
Cdd:cd07209    1 LVLSGGGALGAYQAGVLKALAEAG-IEPDIISGTSIGAINGALIAGG----DPEAVER-LEKLWRELSREDVF------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  92 vdrmlgiwgggdeppgllwfdmvsrfaspydfnplninpLRDLIEELIDFDKVRACN--SVSLFIAATNVRTGKIKLFER 169
Cdd:cd07209   68 ---------------------------------------LRGLLDRALDFDTLRLLAilFAGLVIVAVNVLTGEPVYFDD 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 170 --PELTADHIMASACLPMVFQAVEIDGVPYWDGGYMGNPALFPLF-YGAasDDVLLVqinPIEREETPRSAREIQNRLTE 246
Cdd:cd07209  109 ipDGILPEHLLASAALPPFFPPVEIDGRYYWDGGVVDNTPLSPAIdLGA--DEIIVV---SLSDKGRDDRKGTPPTTLIE 183

                        250       260
                 ....*....|....*....|....
gi 919436017 247 ITFNaTLLREMRAIEFVTRLIDEG 270
Cdd:cd07209  184 ILPR-LFLRSGLDSERIRHNLELG 206
Patatin pfam01734
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. ...
 12-205 1.08e-22

Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 396341  Cd Length: 190  Bit Score: 93.44  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017   12 LALQGGGAHGAFTWGVVDALLEDGrLAIEAISGTSAGAMNAVVMTQGfieAGIDGARRDLETFWRRVSRDGALSPLqRSL 91
Cdd:pfam01734   1 LVLSGGGARGAYHLGVLKALGEAG-IRFDVISGTSAGAINAALLALG---RDPEEIEDLLLELDLNLFLSLIRKRA-LSL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017   92 VDRMLGIWGGGDEPPGLLWFDMVSRFaspydFNPLNINPLRDLIEELIDFDKVRACNSVSLFIAATNVRTGKIKLFERPE 171
Cdd:pfam01734  76 LALLRGLIGEGGLFDGDALRELLRKL-----LGDLTLEELAARLSLLLVVALRALLTVISTALGTRARILLPDDLDDDED 150

                         170       180       190
                  ....*....|....*....|....*....|....
gi 919436017  172 LtADHIMASACLPMVFQAVEIDGVPYWDGGYMGN 205
Cdd:pfam01734 151 L-ADAVLASSALPGVFPPVRLDGELYVDGGLVDN 183
 
Name Accession Description Interval E-value
RssA COG1752
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function ...
 4-324 7.31e-66

Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only];


Pssm-ID: 441358 [Multi-domain]  Cd Length: 261  Bit Score: 208.60  E-value: 7.31e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017   4 PKAEKSICLALQGGGAHGAFTWGVVDALLEDGrLAIEAISGTSAGAMNAVVMTQGFieagidgARRDLETFWRRVSRDGA 83
Cdd:COG1752    1 APARPKIGLVLSGGGARGAAHIGVLKALEEAG-IPPDVIAGTSAGAIVGALYAAGY-------SADELEELWRSLDRRDL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  84 LSPLqrslVDRMLGIWGGGDEPPGLLwfdmvsrfaspydfnplNINPLRDLIEELI---DFDKVRacnsVSLFIAATNVR 160
Cdd:COG1752   73 FDLS----LPRRLLRLDLGLSPGGLL-----------------DGDPLRRLLERLLgdrDFEDLP----IPLAVVATDLE 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 161 TGKIKLFERPELtADHIMASACLPMVFQAVEIDGVPYWDGGYMGNPALFPLFYGAAsDDVLLVQINPIEREetPRSAREI 240
Cdd:COG1752  128 TGREVVFDSGPL-ADAVRASAAIPGVFPPVEIDGRLYVDGGVVNNLPVDPARALGA-DRVIAVDLNPPLRK--LPSLLDI 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 241 QNRLTEITFNATLLREMrAIEFVTRLIDEgklskdeykrvlmhridadllmkRVTAASRLsaDWSLLQRLADLGRQAARK 320
Cdd:COG1752  204 LGRALEIMFNSILRREL-ALEPADILIEP-----------------------DLSGISLL--DFSRAEELIEAGYEAARR 257


                 ....
gi 919436017 321 WLKE 324
Cdd:COG1752  258 ALDE 261
Pat_hypo_Ecoli_Z1214_like cd07209
Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase ...
 12-270 1.64e-35

Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.


Pssm-ID: 132848 [Multi-domain]  Cd Length: 215  Bit Score: 128.56  E-value: 1.64e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  12 LALQGGGAHGAFTWGVVDALLEDGrLAIEAISGTSAGAMNAVVMTQGfieaGIDGARRdLETFWRRVSRDGALsplqrsl 91
Cdd:cd07209    1 LVLSGGGALGAYQAGVLKALAEAG-IEPDIISGTSIGAINGALIAGG----DPEAVER-LEKLWRELSREDVF------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  92 vdrmlgiwgggdeppgllwfdmvsrfaspydfnplninpLRDLIEELIDFDKVRACN--SVSLFIAATNVRTGKIKLFER 169
Cdd:cd07209   68 ---------------------------------------LRGLLDRALDFDTLRLLAilFAGLVIVAVNVLTGEPVYFDD 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 170 --PELTADHIMASACLPMVFQAVEIDGVPYWDGGYMGNPALFPLF-YGAasDDVLLVqinPIEREETPRSAREIQNRLTE 246
Cdd:cd07209  109 ipDGILPEHLLASAALPPFFPPVEIDGRYYWDGGVVDNTPLSPAIdLGA--DEIIVV---SLSDKGRDDRKGTPPTTLIE 183

                        250       260
                 ....*....|....*....|....
gi 919436017 247 ITFNaTLLREMRAIEFVTRLIDEG 270
Cdd:cd07209  184 ILPR-LFLRSGLDSERIRHNLELG 206
YjjU COG4667
Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];
10-324 1.76e-24

Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];


Pssm-ID: 443704 [Multi-domain]  Cd Length: 281  Bit Score: 100.62  E-value: 1.76e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  10 ICLALQGGGAHGAFTWGVVDALLEDGrLAIEAISGTSAGAMNAVvmtqGFIEAGIDGARRdletFWRRVSRDgalsplqr 89
Cdd:COG4667    6 TALVLEGGGMRGIFTAGVLDALLEEG-IPFDLVIGVSAGALNGA----SYLSRQPGRARR----VITDYATD-------- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  90 slvDRMLGIW----GGGdeppgllWFDMvsRFAspYDFNPLNINPLrdlieeliDFDKVRAcNSVSLFIAATNVRTGKIK 165
Cdd:COG4667   69 ---PRFFSLRnflrGGN-------LFDL--DFL--YDEIPNELLPF--------DFETFKA-SPREFYVVATNADTGEAE 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 166 LFERPELTADH---IMASACLPMVFQAVEIDGVPYWDGGyMGNPalFPL--FYGAASDDVLLVQINPIEREETPRSAREI 240
Cdd:COG4667  126 YFSKKDDDYDLldaLRASSALPLLYPPVEIDGKRYLDGG-VADS--IPVreAIRDGADKIVVILTRPRGYRKKPSKFKRL 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 241 QNRLTE---ITFNATLLRE---MRAIEFVTRLIDEGKLskdeykRVLmhRIDADLLMKRVTaaSRLSAdwslLQRLADLG 314
Cdd:COG4667  203 LRRLYRkypKLVEALLNRHeryNETLEFIEQLEKEGKI------FVI--RPPKPLTVSRLE--RDPEK----LRALYELG 268

                        330
                 ....*....|
gi 919436017 315 RQAARKWLKE 324
Cdd:COG4667  269 YEDARKFLAE 278
Pat_hypo_Ecoli_yjju_like cd07208
Hypothetical patatin similar to yjju protein of Escherichia coli; Patatin-like phospholipase ...
 12-318 5.28e-23

Hypothetical patatin similar to yjju protein of Escherichia coli; Patatin-like phospholipase similar to yjju protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins, and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.


Pssm-ID: 132847 [Multi-domain]  Cd Length: 266  Bit Score: 96.14  E-value: 5.28e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  12 LALQGGGAHGAFTWGVVDALLEDGRLAIEAISGTSAGAMNAVvmtqGFIeAGIDGARRDLET---------FWRRVSRDG 82
Cdd:cd07208    1 LVLEGGGMRGAYTAGVLDAFLEAGIRPFDLVIGVSAGALNAA----SYL-SGQRGRALRINTkyatdprylGLRSLLRTG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  83 ALsplqrslvdrmlgiwgggdepPGLLW-FDMVSRFASPYDFNPLNINPLRdlieelidfdkvracnsvsLFIAATNVRT 161
Cdd:cd07208   76 NL---------------------FDLDFlYDELPDGLDPFDFEAFAASPAR-------------------FYVVATDADT 115

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 162 GKIKLFERPELTADH---IMASACLPMVFQAVEIDGVPYWDGGyMGNPALFPLFYGAASDDVLLVQINPIEREETPRSAR 238
Cdd:cd07208  116 GEAVYFDKPDILDDLldaLRASSALPGLFPPVRIDGEPYVDGG-LSDSIPVDKAIEDGADKIVVILTRPRGYRKKPSKSS 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 239 EIQNRLTEITFNA--TLLREM----RAIEFVTRLIDEGKlskdeykrvlMHRIDADLLMKrvtaASRLSADWSLLQRLAD 312
Cdd:cd07208  195 PLAKLLYRKYPNLveALLRRHsrynETLEFIRRLEAEGK----------IFVIAPEKPLK----VSRLERDPEKLEALYD 260


                 ....*.
gi 919436017 313 LGRQAA 318
Cdd:cd07208  261 LGYEDA 266
Patatin pfam01734
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. ...
 12-205 1.08e-22

Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 396341  Cd Length: 190  Bit Score: 93.44  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017   12 LALQGGGAHGAFTWGVVDALLEDGrLAIEAISGTSAGAMNAVVMTQGfieAGIDGARRDLETFWRRVSRDGALSPLqRSL 91
Cdd:pfam01734   1 LVLSGGGARGAYHLGVLKALGEAG-IRFDVISGTSAGAINAALLALG---RDPEEIEDLLLELDLNLFLSLIRKRA-LSL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017   92 VDRMLGIWGGGDEPPGLLWFDMVSRFaspydFNPLNINPLRDLIEELIDFDKVRACNSVSLFIAATNVRTGKIKLFERPE 171
Cdd:pfam01734  76 LALLRGLIGEGGLFDGDALRELLRKL-----LGDLTLEELAARLSLLLVVALRALLTVISTALGTRARILLPDDLDDDED 150

                         170       180       190
                  ....*....|....*....|....*....|....
gi 919436017  172 LtADHIMASACLPMVFQAVEIDGVPYWDGGYMGN 205
Cdd:pfam01734 151 L-ADAVLASSALPGVFPPVRLDGELYVDGGLVDN 183
Pat_hypo_W_succinogenes_WS1459_like cd07210
Hypothetical patatin similar to WS1459 of Wolinella succinogenes; Patatin-like phospholipase. ...
 12-244 7.57e-19

Hypothetical patatin similar to WS1459 of Wolinella succinogenes; Patatin-like phospholipase. This family predominantly consists of bacterial patatin glycoproteins. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.


Pssm-ID: 132849 [Multi-domain]  Cd Length: 221  Bit Score: 83.93  E-value: 7.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  12 LALQGGGAHGAFTWGVVDALLEDGrLAIEAISGTSAGAMNAvvmtqGFIEAGIDGA----------RRDLETFWRRVSRD 81
Cdd:cd07210    3 LVLSSGFFGFYAHLGFLAALLEMG-LEPSAISGTSAGALVG-----GLFASGISPDemaelllsleRKDFWMFWDPPLRG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  82 GALSplqrslvdrmlgiwggGDeppgllwfdmvsRFaspydfnplninplRDLIEELIDFDKVRACnSVSLFIAATNVRT 161
Cdd:cd07210   77 GLLS----------------GD------------RF--------------AALLREHLPPDRFEEL-RIPLAVSVVDLTS 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017 162 GKIKLFERPELtADHIMASACLPMVFQAVEIDGVPYWDGGYMGNPALFPLFYgaASDDVLLVQINPIEREETPRSAREIQ 241
Cdd:cd07210  114 RETLLLSEGDL-AEAVAASCAVPPLFQPVEIGGRPFVDGGVADRLPFDALRP--EIERILYHHVAPRRPWERLNIIGKIS 190


                 ...
gi 919436017 242 NRL 244
Cdd:cd07210  191 RAL 193
Pat_PNPLA6_PNPLA7_NTE1_like cd07205
Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; ...
 12-205 4.90e-15

Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Patatin-like phospholipase domain containing protein 6 (PNPLA6) and protein 7 (PNPLA7) are included in this family. PNPLA6 is commonly known as Neuropathy Target Esterase (NTE). NTE has at least two functional domains: the N-terminal domain putatively regulatory domain and the C-terminal catalytic domain which shows esterase activity. NTE shows phospholipase activity for lysophosphatidylcholine (LPC) and phosphatidylcholine (PC). Exposure of NTE to organophosphates leads to organophosphate-induced delayed neurotoxicity (OPIDN). OPIDN is a progressive neurological condition that is characterized by weakness, paralysis, pain, and paresthesia. PNPLA7 is an insulin-regulated phospholipase that is homologus to Neuropathy Target Esterase (NTE or PNPLA6) and is also known as NTE-related esterase (NRE). Human NRE is predominantly expressed in prostate, white adipose, and pancreatic tissue. NRE hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid, but shows no lipase activity with substrates like triacylglycerols (TG), cholesteryl esters, retinyl esters (RE), phosphatidylcholine (PC), or monoacylglycerol (MG). This family includes subfamily of PNPLA6 (NTE) and PNPLA7 (NRE)-like phospholipases.


Pssm-ID: 132844 [Multi-domain]  Cd Length: 175  Bit Score: 72.19  E-value: 4.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  12 LALQGGGAHGAFTWGVVDALLEDGrLAIEAISGTSAGAMNAvvmtqGFIEAGIDgARRDLETFWRRVSRDGALSPLQRSL 91
Cdd:cd07205    3 LALSGGGARGLAHIGVLKALEEAG-IPIDIVSGTSAGAIVG-----ALYAAGYS-PEEIEERAKLRSTDLKALSDLTIPT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  92 vdrmlgiwgggdepPGLLWFDMVSRFASPYdFNPLNINPLRdlieelidfdkvracnsVSLFIAATNVRTGKIKLFERPE 171
Cdd:cd07205   76 --------------AGLLRGDKFLELLDEY-FGDRDIEDLW-----------------IPFFIVATDLTSGKLVVFRSGS 123

                        170       180       190
                 ....*....|....*....|....*....|....
gi 919436017 172 LtADHIMASACLPMVFQAVEIDGVPYWDGGYMGN 205
Cdd:cd07205  124 L-VRAVRASMSIPGIFPPVKIDGQLLVDGGVLNN 156
Pat_ExoU_VipD_like cd07207
ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; ExoU, a 74-kDa enzyme, is ...
 12-205 2.30e-13

ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; ExoU, a 74-kDa enzyme, is a potent virulence factor of Pseudomonas aeruginosa. One of the pathogenic mechanisms of P. aeruginosa is to induce cytotoxicity by the injection of effector proteins (e.g. ExoU) using the type III secretion (T3S) system. ExoU is homologus to patatin and also has the conserved catalytic residues of mammalian calcium-independent (iPLA2) and cytosolic (cPLA2) PLA2. In vitro, ExoU cytotoxity is blocked by the inhibitor of cytosolic and Ca2-independent phospholipase A2 (cPLA2 and iPLA2) enzymes, suggesting that phospholipase A2 inhibitors may represent a novel mode of treatment for acute P. aeruginosa infections. ExoU requires eukaryotic superoxide dismutase as a cofactor and cleaves phosphatidylcholine and phosphatidylethanolamine in vitro. VipD, a 69-kDa cytosolic protein, belongs to the members of Legionella pneumophila family and is homologus to ExoU from Pseudomonas. Even though VipD shows high sequence similarity with several functional regions of ExoU (e.g. oxyanion hole, active site serine, active site aspartate), it has been shown to have no phospholipase activity. This family includes ExoU from Pseudomonas aeruginosa and VipD of Legionella pneumophila.


Pssm-ID: 132846  Cd Length: 194  Bit Score: 67.69  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  12 LALQGGGAHGAFTWGVVDALLEDGRLaIEAISGTSAGAMNAvvmtqGFIEAGIDGArrDLETFwrrvsrdgALSPLQRSL 91
Cdd:cd07207    2 LVFEGGGAKGIAYIGALKALEEAGIL-KKRVAGTSAGAITA-----ALLALGYSAA--DIKDI--------LKETDFAKL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  92 VDRmlgIWGGGDEPPGLLWFDMVSRFASPYDFnplninpLRDLIEEL---IDFDKVRAC----NSVSLFIAATNVRTGKI 164
Cdd:cd07207   66 LDS---PVGLLFLLPSLFKEGGLYKGDALEEW-------LRELLKEKtgnSFATSLLRDldddLGKDLKVVATDLTTGAL 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 919436017 165 KLFER---PELT-ADHIMASACLPMVFQAVEIDGVPYW-DGGYMGN 205
Cdd:cd07207  136 VVFSAettPDMPvAKAVRASMSIPFVFKPVRLAKGDVYvDGGVLDN 181
Patatin cd07198
Patatin-like phospholipase; Patatin is a storage protein of the potato tuber that shows ...
 12-205 5.76e-11

Patatin-like phospholipase; Patatin is a storage protein of the potato tuber that shows Phospholipase A2 activity (PLA2; EC 3.1.1.4). Patatin catalyzes the nonspecific hydrolysis of phospholipids, glycolipids, sulfolipids, and mono- and diacylglycerols, thereby showing lipid acyl hydrolase activity. The active site includes an oxyanion hole with a conserved GGxR motif; it is found in almost all the members of this family. The catalytic dyad is formed by a serine and an aspartate. Patatin belongs to the alpha-beta hydrolase family which is identified by a characteristic nucleophile elbow with a consensus sequence of Sm-X-Nu-Sm (Sm = small residue, X = any residue and Nu = nucleophile). Members of this family have been found also in vertebrates. This family includes PNPLA (1-9), TGL (3-5), ExoU-like, and SDP1-like subfamilies. There are some additional hypothetical proteins included in this family.


Pssm-ID: 132837 [Multi-domain]  Cd Length: 172  Bit Score: 60.43  E-value: 5.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  12 LALQGGGAHGAFTWGVVDALLEDGRLaIEAISGTSAGAMNAVVMTqgfieagidgARRDLEtfwrrvsrdgalspLQRSL 91
Cdd:cd07198    1 LVLSGGGALGIYHVGVAKALRERGPL-IDIIAGTSAGAIVAALLA----------SGRDLE--------------EALLL 55

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  92 VDRMLGIWgggdeppgllwfdmvsRFASPYDFNPLNiNPLRDLIEELID--FDKVRACNSVSLFIAATNVRTGK--IKLF 167
Cdd:cd07198   56 LLRLSREV----------------RLRFDGAFPPTG-RLLGILRQPLLSalPDDAHEDASGKLFISLTRLTDGEnvLVSD 118

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 919436017 168 ERPELTADHIMASACLPMVFQAVE--IDGVPYWDGGYMGN 205
Cdd:cd07198  119 TSKGELWSAVRASSSIPGYFGPVPlsFRGRRYGDGGLSNN 158
Pat_PNPLA4 cd07222
Patatin-like phospholipase domain containing protein 4; PNPLA4, also known as GS2 (gene ...
 11-210 9.61e-07

Patatin-like phospholipase domain containing protein 4; PNPLA4, also known as GS2 (gene sequence-2), shows both lipase and transacylation activities. GS2 lipase is expressed in various tissues, predominantly in muscle and adipocytes tissue. It is also expressed in keratinocytes and shows retinyl ester hydrolase, acylglycerol, TG hydrolase, and PLA2 activity. This family includes patatin-like proteins: GS2 from mammals, PNPLA4 (Patatin-like phospholipase domain-containing protein 4), and iPLA2-eta (Calcium-independent phospholipase A2) from Homo sapiens.


Pssm-ID: 132861 [Multi-domain]  Cd Length: 246  Bit Score: 49.25  E-value: 9.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  11 CLALQGGGAHGAFTWGVVDALLEDGRL---AIEAISGTSAGAMNAVVMTqgFIEAGIDGARRDLETFWRRVSRD--GALS 85
Cdd:cd07222    1 NLSFAACGFLGIYHLGAAKALLRHGKKllkRVKRFAGASAGSLVAAVLL--TAPEKIEECKEFTYKFAEEVRKQrfGAMT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  86 PlqrslvdrmlgiwgggdeppgllwfdmvsrfasPYDFNplniNPLRDLIEELIDFDKVRACNSvSLFIAATNVRTGK-- 163
Cdd:cd07222   79 P---------------------------------GYDFM----ARLRKGIESILPTDAHELAND-RLHVSITNLKTRKny 120

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 919436017 164 -IKLFERPELTADHIMASACLPMV--FQAVEIDGVPYWDGGYMGNPALFP 210
Cdd:cd07222  121 lVSNFTSREDLIKVLLASCYVPVYagLKPVEYKGQKWIDGGFTNSLPVLP 170
Pat_TGL4-5_like cd07230
Triacylglycerol lipase 4 and 5; TGL4 and TGL5 are triacylglycerol lipases that are involved in ...
 12-189 9.32e-06

Triacylglycerol lipase 4 and 5; TGL4 and TGL5 are triacylglycerol lipases that are involved in triacylglycerol mobilization and degradation; they are found in lipid particles. Tgl4 is a functional ortholog of mammalian adipose TG lipase (ATGL) and is phosphorylated and activated by cyclin-dependent kinase 1 (Cdk1/Cdc28). TGL4 is 30% homologus to TGL3, whereas TGL5 is 26% homologus to TGL3. This family includes TGL4 (STC1) and TGL5 (STC2) from Saccharomyces cerevisiae.


Pssm-ID: 132868  Cd Length: 421  Bit Score: 47.22  E-value: 9.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  12 LALQGGGAHGAFTWGVVDALLEDgRLAIEAISGTSAGAmnavvmtqgfIEAGIDGARRDLETFwrrvsrdgalsPLQRSL 91
Cdd:cd07230   76 LLLSGGGTFGMFHIGVLKALFEA-NLLPRIISGSSAGS----------IVAAILCTHTDEEIP-----------ELLEEF 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919436017  92 VDRMLGIWGGGDEPPGLLwfDMVSRF---ASPYDFNPLnINPLRDLIEELIdfdkvracnsvslFIAATNvRTGKI---- 164
Cdd:cd07230  134 PYGDFNVFEDPDQEENVL--QKLSRFlkyGSWFDISHL-TRVMRGFLGDLT-------------FQEAYN-RTRRIlnit 196

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 919436017 165 ----KLFERPEL----TADHIM------ASACLPMVFQA 189
Cdd:cd07230  197 vspaSIYELPRLlnyiTAPNVLiwsavcASCSVPGVFPS 235
Pat_TGL3-4-5_SDP1 cd07206
Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Triacylglycerol lipases are ...
 11-74 3.03e-04

Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Triacylglycerol lipases are involved in triacylglycerol mobilization and degradation; they are found in lipid particles. TGL4 is 30% homologus to TGL3, whereas TGL5 is 26% homologus to TGL3. Sugar-Dependent 1 (SDP1) lipase has a patatin-like acyl-hydrolase domain that initiates the breakdown of storage oil in germinating Arabidopsis seeds. This family includes subfamilies of proteins: TGL3, TGL4, TGL5, and SDP1.


Pssm-ID: 132845  Cd Length: 298  Bit Score: 41.81  E-value: 3.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 919436017  11 CLALQGGGAHGAFTWGVVDALLEDGRLAiEAISGTSAGAmnavvmtqgfIEAGIDGARRDLETF 74
Cdd:cd07206   71 ALMLSGGASLGLFHLGVVKALWEQDLLP-RVISGSSAGA----------IVAALLGTHTDEELI 123
Pat_PLPL cd07232
Patain-like phospholipase; Patatin-like phospholipase. This family consists of various patatin ...
 12-52 6.19e-04

Patain-like phospholipase; Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants and fungi. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 132870  Cd Length: 407  Bit Score: 41.48  E-value: 6.19e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 919436017  12 LALQGGGAHGAFTWGVVDALLEDGRLaIEAISGTSAGAMNA 52
Cdd:cd07232   70 LCLSGGAAFAYYHFGVVKALLDADLL-PNVISGTSGGSLVA 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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