|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
20-418 |
5.87e-79 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 249.50 E-value: 5.87e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 20 GGTLEFYDFIIFVFFAEYIANVFFPKDMSEFWALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTF 99
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 100 VLAFIPGYETLGFLAPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAFFS 179
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 180 IEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKKESSLSSFPLKDLFKEKdiVKNLFSSMMMTWVLTGCVIVL 259
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLTKH--RKPFLLGLGLVIATTTTFYLI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 260 VLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELKNLVLVCIL 339
Cdd:TIGR00883 239 TTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 340 YSII-CFLGGINVFAPILMSEVFRAKIRFSGISFSYNISYAISGGITPQLVFWLNTLASKNenpflYGMSIYMIFLALLA 418
Cdd:TIGR00883 319 VLGMaLIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGDW-----YAIGYYLAALALIG 393
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
17-424 |
3.33e-76 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 242.82 E-value: 3.33e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 17 SSLGGTLEFYDFIIFVFFAEYIANVFFPKDMSEFWALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVL 96
Cdd:cd17369 7 SLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 97 PTFVLAFIPGYETLGFLAPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINA 176
Cdd:cd17369 87 ATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 177 FFSIEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKKESSLSSFPLKDLFKE--KDIVKNLFsSMMMTWVLTG 254
Cdd:cd17369 167 LLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRhwRALLLAIG-LRLAENVLFY 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 255 CVIVLVLlmpKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELKNLV 334
Cdd:cd17369 246 LFTTFAL---SYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 335 LVCILYSIICFLGGInVFAPI--LMSEVFRAKIRFSGISFSYNISYAISGGITPQLVFWLNTLASKnenpfLYGMSIYMI 412
Cdd:cd17369 323 IVLAAVVVLGVLHGM-MYGPQaaFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGS-----WWPVALYLA 396
|
410
....*....|..
gi 919291524 413 FLALLAICAVFI 424
Cdd:cd17369 397 ALAVISLVAALF 408
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
18-428 |
1.27e-65 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 215.62 E-value: 1.27e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 18 SLGGTLEFYDFIIFVFFAEYIANVFFPKDMSEFwALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLP 97
Cdd:cd17367 5 SVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTV-ALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 98 TFVLAFIPGYETLGFLAPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAF 177
Cdd:cd17367 84 SLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 178 FSIEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKKESSLSSFPLKDLFKEKdivKNLFSSMMMTWVLTGCVI 257
Cdd:cd17367 164 LGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELRRHP---RELLLVVGLTAGGTLAFY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 258 VLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELKN----L 333
Cdd:cd17367 241 TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSpytaF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 334 VLVCILYSIICFLGGINvfaPILMSEVFRAKIRFSGISFSYNISYAISGGITPQLVFWlntLASKNENPFLYGmsiYMIF 413
Cdd:cd17367 321 ALVLVGLVFLSGYTSIN---AVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALW---LKSIGHEWVFFW---YVAG 391
|
410
....*....|....*
gi 919291524 414 LALLAICAVFIVKDK 428
Cdd:cd17367 392 LIAISLVVYLRMPET 406
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
17-426 |
1.21e-58 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 197.21 E-value: 1.21e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 17 SSLGGTLEFYDFIIFVFFAEYIANVFFPKDmSEFWALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVL 96
Cdd:cd17368 4 ATSGNALEFFDFGVYGFFAVYIGRLFFPSG-SEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 97 PTFVLAFIPGYETLGFLAPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINA 176
Cdd:cd17368 83 GTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 177 FFSIEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKKEsSLSSFPLKDLFKEKDIVKNlfsSMMMTWVLTGCV 256
Cdd:cd17368 163 TLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKAR-PTRRELFALLANNRRIILL---GMLLVAGSTVTF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 257 IVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELKNL-VL 335
Cdd:cd17368 239 YFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFgRL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 336 VCILYSIICFLGGINVFAPILMSEVFRAKIRFSGISFSYNISYAISGGITPQLVFWLNTLASKNENPflygmSIYMIFLA 415
Cdd:cd17368 319 LLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGSPLAP-----AWYLMGAA 393
|
410
....*....|.
gi 919291524 416 LLAICAVFIVK 426
Cdd:cd17368 394 LLGLLATLMLR 404
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
17-427 |
6.40e-52 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 178.71 E-value: 6.40e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 17 SSLGGTLEFYDFIIFVFFAEYIANVFFPKDmSEFWALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVL 96
Cdd:cd17366 4 AALGNAMEWFDFGVYGYLAVTIGKVFFPGG-DPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 97 PTFVLAFIPGYETLGFLAPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINA 176
Cdd:cd17366 83 STFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 177 FFSIEEIAAYAWRIAFFVGGIFGIISIYLRR-FLQETPVFkqmkkesslssfplkdlfkekdIVKNLFSSMMMTWvltgc 255
Cdd:cd17366 163 LLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRpLLICIGLV----------------------LVFNVTNYMLLSY----- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 256 vivlvllMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYaLYELKNLVL 335
Cdd:cd17366 216 -------MPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFL-LMNSGSIAA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 336 VCILYSIICFLggINVFAPILMS---EVFRAKIRFSGISFSYNISYAISGGITPQLVFWlntLASKNENPFLygMSIYMI 412
Cdd:cd17366 288 IFIGLLVLGLL--LSCYTATMAStlpALFPTHVRYSALAIAFNISVSLFGGTTPLVASW---LVSATGNPLM--PAYYLM 360
|
410
....*....|....*
gi 919291524 413 FLALLAICAVFIVKD 427
Cdd:cd17366 361 VAAVVGLVAVLFLTE 375
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
12-415 |
1.09e-51 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 181.06 E-value: 1.09e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 12 KILGLSSLGGTLEFYDFIIFVFFAEYIANVFFPkDMSEFWALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSI 91
Cdd:PRK10642 16 KAITAASLGNAMEWFDFGVYGFVAYALGKVFFP-GADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 92 LLMVLPTFVLAFIPGYETLGFLAPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVF 171
Cdd:PRK10642 95 VIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 172 LIINAFFSIEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQ----MKKESSLS-SFPLKDLFKEkdIVKNLFSSM 246
Cdd:PRK10642 175 VLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQhvdkLEQGDREGlQDGPKVSFKE--IATKHWRSL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 247 MmtwVLTGCVIV-------LVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFF 319
Cdd:PRK10642 253 L---TCIGLVIAtnvtyymLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILGSVALFVL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 320 SFLYFYALYELKNLVLVC---ILYSII-CFLGginVFAPILMSeVFRAKIRFSGISFSYNISYAISgGITPQLVFWLNTL 395
Cdd:PRK10642 330 AIPAFILINSNVIGLIFAgllMLAVILnCFTG---VMASTLPA-MFPTHIRYSALAAAFNISVLVA-GLTPTLAAWLVES 404
|
410 420
....*....|....*....|
gi 919291524 396 ASKNENPFLYGMSIYMIFLA 415
Cdd:PRK10642 405 TQNLMMPAYYLMVVAVIGLI 424
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
20-425 |
2.90e-49 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 173.21 E-value: 2.90e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 20 GGTLEFYDFIIFVFFAEYIANVFFPKDmSEFWALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTF 99
Cdd:PRK15075 23 GNFLEMFDFFLFGFYATAIAKTFFPAG-NEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGTL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 100 VLAFIPGYETLGFLAPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAFFS 179
Cdd:PRK15075 102 LIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQWLS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 180 IEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKKESSLssfplkdlfkekdivKNLFSSMMMTW--VLTGCVI 257
Cdd:PRK15075 182 PAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSM---------------REIFRSLAANWriVLAGMLM 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 258 VLV---------LLMPKFMPSILNLSGVEGsylqILGILGIALGGAF----MGYLVDKFGLFKICIFFSLTFVFFSF--- 321
Cdd:PRK15075 247 VAMttvsfylitVYTPTFGKTVLHLSAADS----LLVTLCVGVSNFIwlpiGGALSDRIGRRPVLIAFTVLAILTAYpal 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 322 LYFYALYELKNLVLVCILYSIicFLGGINVFAPILMSEVFRAKIRFSGISFSYNISYAISGGITPQLVFWLNTLASKNEN 401
Cdd:PRK15075 323 SWLVAAPSFARMLAVELWLSF--LYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTGDKAA 400
|
410 420
....*....|....*....|....
gi 919291524 402 PflygmSIYMIFLALLAICAVFIV 425
Cdd:PRK15075 401 P-----GYWLSFAAVCGLIATLVL 419
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-424 |
2.06e-48 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 168.55 E-value: 2.06e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 14 LGLSSLGGTLEFYDFIIFVFFAEYIANVFfpkdmSEFWALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILL 93
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 94 MVLPTFVLAFIPGyetlgflaPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLI 173
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 174 INAFFSIEeiaaYAWRIAFFVGGIFGIISIYLRRflqetpvfkqmkkesslssfplkdlfkekdivkNLFSSMMMTWVLT 253
Cdd:cd17316 148 LIPLLSGD----WGWRILFLIGALPALLALLLRR---------------------------------RTLLLILLWFFIS 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 254 GCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELKNL 333
Cdd:cd17316 191 FGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 334 VLVCILYSIICFLGGINVFaPILMSEVFRAKIRFSGISFSYNISYAISGGITPQLVFWLNTlasknenpfLYGMSIYMIF 413
Cdd:cd17316 271 LLLLLFILSFFVGGVWGAL-YAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS---------TGGTGVPALI 340
|
410
....*....|.
gi 919291524 414 LALLAICAVFI 424
Cdd:cd17316 341 LALLAIVALIV 351
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
13-417 |
2.67e-43 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 157.28 E-value: 2.67e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 13 ILGLSSlGGTLEFYDFIIFVFFAEYIANVFFPKDMSEFwALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSIL 92
Cdd:PRK10406 24 IVGASS-GNLVEWFDFYVYSFCSLYFAHIFFPSGNTTT-QLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVC 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 93 LMVLPTFVLAFIPGYETLGFLAPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFL 172
Cdd:PRK10406 102 MMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 173 IINAFFSIEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETpvfkqmkkeSSLSSFPLKDLFKEKDIVKNLFSSMMMTWVL 252
Cdd:PRK10406 182 VLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET---------SQQETRALKEAGSLKGLWRNRRAFIMVLGFT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 253 TG---CVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYE 329
Cdd:PRK10406 253 AAgslCFYTFTTYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAALFTVPILSALQN 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 330 LKNLV----LVCILYSIICFLGGInvfAPILMSEVFRAKIRFSGISFSYNISYAISGGITPQLVFWLNTLASknENPFLY 405
Cdd:PRK10406 333 VSSPYaafgLVMCALLIVSFYTSI---SGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSIGM--ETAFFW 407
|
410
....*....|..
gi 919291524 406 GMSIyMIFLALL 417
Cdd:PRK10406 408 YVTL-MAVVAFL 418
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
17-386 |
1.13e-36 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 139.10 E-value: 1.13e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 17 SSLGGTLEFYDFIIFVFFAEYIANV-FFPKdMSEFWALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMV 95
Cdd:PRK09952 27 SFAGAVVDWYDFLLYGITAALVFNReFFPQ-VSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVWMMG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 96 LPTFVLAFIPGYETLGFLAPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIIN 175
Cdd:PRK09952 106 IATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLIS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 176 AFFSIEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVF--KQMKKESSLSSFPLKDLFKEKDIVKNLFSSMMMTWVLT 253
Cdd:PRK09952 186 MMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFeqQQHEQAAAKKRIPVIEALLRHPGAFLKIIALRLCELLT 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 254 GCVIVLVLLmpkfMPSILNLsGVEGSYLQILGILGIALGGA---FMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALyEL 330
Cdd:PRK09952 266 MYIVTAFAL----NYSTQNL-GLPRELFLNIGLLVGGLSCLtipCFAWLADRFGRRRVYITGALIGTLSAFPFFMAL-EA 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 919291524 331 KNL---VLVCILYSIICFLGGINVFAPiLMSEVFRAKIRFSGISFSYNISYAISGGITP 386
Cdd:PRK09952 340 QSIfwiVFFSIMLANIAHDMVVCVQQP-MFTEMFGASYRYSGAGVGYQVASVVGGGFTP 397
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-316 |
3.21e-26 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 107.20 E-value: 3.21e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 8 TKEIKILGLSSLGGTLEFYDFIIFVFFAEYIANVFfpkDMSEFWALLntygAFAAGYLARPLGGIVMAHFGDKFGRKNMF 87
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADL---GASSAQLGW----IVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 88 MLSILLMVLPTFVLAFIPGyetlgflaPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLG 167
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 168 SIVFLIINAFFSieeiaayaWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKKESSLSSFPLKDLFKEKDIVKNLFSSMM 247
Cdd:COG0477 155 PLLGGLLVAALG--------WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLL 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 919291524 248 MTWVLTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTF 316
Cdd:COG0477 227 LALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
2-392 |
1.68e-23 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 101.66 E-value: 1.68e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 2 RKSKFETKEIKILGLSSLGGTLEFYDFIIFVFFAEYIANVFFPKDMSEFWAllntygaFAAGYLARPLGGIVMAHFGDKF 81
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFL-------FSAGLIGMAFGALFFGPLADRI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 82 GRKNMFMLSILLMVLPTFVLAFIPGYETLGFLapvlliliRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMA 161
Cdd:TIGR00895 80 GRRRVLLWSILLFSVFTLLCALATNVTQLLIL--------RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 162 LGILLGsivfliinAFFSIEEIAAYAWRIAFFVGGIFGII-SIYLRRFLQETPVFKQMKK----------------ESSL 224
Cdd:TIGR00895 152 IGAAVG--------GFLAGWLIPVFGWRSLFYVGGIAPLLlLLLLMRFLPESIDFLVSKRpetvrrivnaiapqmqAEAQ 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 225 SSFPLKDLF--KEKDIVKNLFS-----SMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGIL---GIALGGA 294
Cdd:TIGR00895 224 SALPEQKSTqgTKRSVFKALFQgktarITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALfnfGGVIGSI 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 295 FMGYLVDKFGLFKICIFFSLTFVFFSFLYFYalYELKNLVLVCILYSIICFLGGINVFaPILMSEVFRAKIRFSGISFSY 374
Cdd:TIGR00895 304 IFGWLADRLGPRVTALLLLLGAVFAVLVGST--LFSPTLLLLLGAIAGFFVNGGQSGL-YALMALFYPTAIRATGVGWAI 380
|
410
....*....|....*...
gi 919291524 375 NISYAISgGITPQLVFWL 392
Cdd:TIGR00895 381 GIGRLGA-IIGPILAGYL 397
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-430 |
1.78e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 101.11 E-value: 1.78e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 13 ILGLSSLGGTLEFYDFIIFVFFAEYIANVFfpkDMSEFWALLntygAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSIL 92
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEF---GLSAAQLGL----LFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 93 LMVLPTFVLAFIPGYEtlgflapvLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFL 172
Cdd:COG2223 79 LLGIGLLLLALAVSYW--------LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 173 IInaffsieeIAAYAWRIAFFVGGIF-GIISIYLRRFLQETPVFKQMKKESSLSSFplKDLFKEKDIVknLFSSMMMtwV 251
Cdd:COG2223 151 LL--------IAAFGWRNAFLILGILlLVVAVLAWLFLRDPPAGAAAAAKASLRDQ--LEALRDPRFW--LLSLLYF--G 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 252 LTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELK 331
Cdd:COG2223 217 TFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 332 NLVLVCILYSIicFLGGINVFAPILMSEVFRAKIRFSGISFSYnISYAISGGITPQLVFWLNTLASKNENPFLygmsiYM 411
Cdd:COG2223 297 LFLVLFLLLGL--ALGGGNGAVFALVPDIFPTKNAGAVYGLVG-AAGGLGGFLGPLLFGALLDATGSYTAAFL-----VF 368
|
410
....*....|....*....
gi 919291524 412 IFLALLAICAVFIVKDKIK 430
Cdd:COG2223 369 AVLALVALVLTLLLYRRPR 387
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-394 |
1.82e-23 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 101.22 E-value: 1.82e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 14 LGLSSLGGTLEFYDFIIFVFFAEYIANVFfpkDMSEFWA-LLNTYGAFAAGylarpLGGIVMAHFGDKFGRKNMFMLSIL 92
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEF---GLDEAEAgLLGTVTLAGGA-----IGGILGGILADRFGRVRVLVITIL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 93 LMVLPTFVLAFIPGYETLGFLapvlliliRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFL 172
Cdd:cd17371 73 LFAVFTLLCGFAQNYWQLLIL--------RALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 173 IINAFFSIEEiaayAWRIAFFVGGIFGIISIYLRRFLQETPVF--KQMKKESSLSSFPLKDLFKEKDIVKNLFSSMMMTW 250
Cdd:cd17371 145 LLFPLLPPEI----AWRVLFLLGALPALLVLFIRRFVKEPPQWqaARAARRHFADRPSLRELFSPPLLRTTLLASLLATG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 251 VLTGCVIVLVlLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYalYEL 330
Cdd:cd17371 221 ALGGYYGITT-WLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFF--LPL 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 919291524 331 KNLVLVCILYSIICFLGGINVFAPILMSEVFRAKIRFSGISFSYNISYAIsGGITPQLVFWLNT 394
Cdd:cd17371 298 SPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFPFLVGFLAT 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
29-381 |
2.31e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 94.66 E-value: 2.31e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 29 IIFVFFAEYIANVFFPKDMSEFWALLNTYGAFAAGY-LARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGY 107
Cdd:COG2814 19 AFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYlLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 108 EtlgflapvLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAFFSieeiaaya 187
Cdd:COG2814 99 W--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 188 WRIAFFVGGIFGIISIYL-RRFLQETPVFKQMKKESSlssfpLKDLFKEkdivKNLFSSMMMTWVLTGCVIVLVLLMPKF 266
Cdd:COG2814 163 WRWVFLVNAVLALLALLLlLRLLPESRPAARARLRGS-----LRELLRR----PRLLLLLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 267 MPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKIcIFFSLTFVFFSFLYFYALYELKNLVLVCILYSIicFL 346
Cdd:COG2814 234 LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL-LLIGLLLLALGLLLLALAGSLWLLLLALFLLGF--GF 310
|
330 340 350
....*....|....*....|....*....|....*
gi 919291524 347 GGINVFAPILMSEVFRAKIRFSGISFSYNISYAIS 381
Cdd:COG2814 311 GLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
18-425 |
2.66e-21 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 95.42 E-value: 2.66e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 18 SLGGTLEFYDFII---FVFFAEYIANVFFPKDMSEFWALLNTYGAFAAGYLA-RPLGGIVMAHFGDKFGRKNMFMLSILL 93
Cdd:pfam00083 6 ALGGFLFGYDTGVigaFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVgCFIGSLFAGKLGDRFGRKKSLLIANVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 94 MVLPTFVLAFIPGYETLGflapvLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLI 173
Cdd:pfam00083 86 FVIGAVLQGAAKGKWSVY-----QLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 174 INAFFsieeiAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQMK-------------------------------KES 222
Cdd:pfam00083 161 LNKTS-----NSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKgrleearevlaklrgvpdvdreldeikdsleAGQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 223 SLSSFPLKDLFKEKDIVKNLFSSMMMTWVLTGCVIVLVLLMPkfmPSILNLSGVEGSYLQILGILGIALGGAFMG-YLVD 301
Cdd:pfam00083 236 EAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYS---TTIFENLGLSDSFLVTIIVGVVNFVFTFIAiFLVD 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 302 KFG---LFKICIFF-SLTFVFFS---FLYFYALYELKNLVLVCILYSIICFLGGINVFAPILMSEVFRAKIRFSGISFSY 374
Cdd:pfam00083 313 RFGrrpLLLLGAAGmAICFVILGivaLLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALAT 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 919291524 375 NISYAISGgitpqLVFWLNTLASKNENPFLYGmSIYMIFLALLAICAVFIV 425
Cdd:pfam00083 393 AANWLANF-----LIGFLFPIITDAIGLGYTF-FIFAGLLVLFIIFVFFFV 437
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
70-425 |
1.56e-20 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 92.73 E-value: 1.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 70 GGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLGFLApvLLILIRIFQGIAIGGELPGAWVFVREYCQEKQK 149
Cdd:cd17364 55 GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRR 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 150 AFFLSCLNSAMALGILLGSIVFLIINAFFSIEEIAA------YAWRIAFFVGGIFGIISIYLRRFLQETpvfkqmkkesS 223
Cdd:cd17364 133 GALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGtyhhadLVWRIVLGLGAIPALSVLYFRKHLLGT----------A 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 224 LSSFPLkdlfkekDIV---KNLFSSMMMT---WVLTGCVIVLVLLMPKFMPSILNLSGVEGSYlqilgilgialggaFMG 297
Cdd:cd17364 203 GTWFLL-------DIAfygQNLFQSTIISaigFSKTMNAYQELFNIAVGQLIIALAGTVPGYW--------------FTV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 298 YLVDKFGLFKICIF-FSLTFVFFSFLYFYALYELKNLVLVCILYSIICFLG--GINVFAPILMSEVFRAKIRfsgiSFSY 374
Cdd:cd17364 262 FLIDRIGRKKIQMMgFFGMTIFLLILAGPYDHWKISTIGFFVLYGLTFFFSnfGPNTTTFIVPAEVFPARVR----STCH 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 919291524 375 NISYAIS--GGITPQLVFwlNTLASKnenpflYGMSIYMIFLALLAICAVFIV 425
Cdd:cd17364 338 GISAASGkiGAIVGSFLF--LSLTQN------IGVRNVLIILAGVALLGIILT 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-430 |
2.60e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 91.86 E-value: 2.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 12 KILGLSSLGGTLEFYDFIIFVFFAEYIANVFFPKDMSEFWAllntygaFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSI 91
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLL-------ASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 92 LLMVLPTFVLAFIPGYetlgflapVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVF 171
Cdd:COG2271 83 LLWGLATLLFGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 172 LIInaffsieeIAAYAWRIAFFVGGIFGIISIYLRrflqetpvfkqmkkesslssfplkdlfkekdIVKNLFSSMMMTWV 251
Cdd:COG2271 155 GWL--------LAAFGWRAAFLILGLPGLLLALLR-------------------------------FWLLALAYFLVYFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 252 LTGcvivLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELK 331
Cdd:COG2271 196 LYG----FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 332 NLVLVCILySIICFLGGINVFAPILMSEVFRAKIRFSGISFSYNISYaISGGITPQLVFWLNTLASknenpFLYGMSIYM 411
Cdd:COG2271 272 ALAIALLF-LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLDATG-----YQAAFLLLA 344
|
410
....*....|....*....
gi 919291524 412 IFLALLAICAVFIVKDKIK 430
Cdd:COG2271 345 ALALLAALLALLLLRETRK 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-386 |
9.88e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 77.84 E-value: 9.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 29 IIFVFFAEYIANVFFPKDMSEFWALLNTYG--AFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPG 106
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIglLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 107 YetlgflapVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAFFSieeiaay 186
Cdd:pfam07690 85 L--------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 187 aWRIAFFVGGIFGIISIYLRRFLQETPvfkQMKKESSLSSFPLKDLFKEKDIVKNLFSSMMMTWVLTGCVIVLVLLMPKF 266
Cdd:pfam07690 150 -WRAAFLILAILSLLAAVLLLLPRPPP---ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 267 MPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELKNLVLVCILYSIICFL 346
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGF 305
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 919291524 347 GGINVFAPILMSEVFRAKIRFSGISFsYNISYAISGGITP 386
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGL-YNTAGSLGGALGP 344
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
59-422 |
3.15e-14 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 73.39 E-value: 3.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 59 AFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLGFLapvlliliRIFQGIAIGGELPGAWV 138
Cdd:cd17365 39 VGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL--------RFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 139 FVREYCQEKQKAFFLSClnsaMALGILLGSivflIINAFFSIEEIAAYAWRIAFFVGGIFGIISIYLrrflqetpvfkqm 218
Cdd:cd17365 111 LVSEYAPARRRSLAVTL----MFCGYPLGA----ALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 219 kkesslssfplkdlfkekdivknLFSSMMMtWVLTGCVIVLVLLMPKFMPSILNLSG---VEGSYLQILGILGIALGGAF 295
Cdd:cd17365 170 -----------------------LRGTLLL-WVTFFMGLLLVYLLNSWLPKLMVEAGyslSQALTITLLLNIGGVIGSLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 296 MGYLVDKFGLFK-ICIFFSLTFVFFSFLyfyaLYELKNLVLVCILYSII-CFLGGINVFAPILMSEVFRAKIRFSGISFS 373
Cdd:cd17365 226 LGWLADRFGPKRvLALFFALGAVSLALL----GVSPASLVLLYVLVFLAgACVNGAQVGLYALAARFYPTEVRATGVGWA 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 919291524 374 YNISY--AISGgitPQLVFWLNTLasknenpflyGMSIYMIFLALLAICAV 422
Cdd:cd17365 302 LGVGRlgAILG---PLLGGLLLAA----------GLGPESVFLALAIPAAL 339
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-417 |
9.85e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 72.07 E-value: 9.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 30 IFVFFAEYIANVFFPKDMSEFWALLNTYG-AFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYE 108
Cdd:cd06174 6 FLTGLARGLISPLLPALLQSFGLSASQLGlLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 109 TLgflapvllILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAFFSieeiaaYAW 188
Cdd:cd06174 86 LL--------LLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG------FGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 189 RIAFFVGGIFGIISIYLRRFLQETPVFKQMKKESSLSSFPLKDLFKEKDIVKNLFSSMMMTWVLTGCVIVLVLLMPKFMP 268
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 269 SILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELKNLVLVCILYSIICFLGG 348
Cdd:cd06174 232 DLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 919291524 349 INVFAPILMSEVFRAKIRFSGIsfsYNISYAISGGITPQLVFWLNTLASKNENPFLYGMSIYMIFLALL 417
Cdd:cd06174 312 PLSFALIAELFPPEIRGTAFGL---LNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
59-304 |
1.27e-12 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 68.84 E-value: 1.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 59 AFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETlgflapvlLILIRIFQGIAIGGELPGAWV 138
Cdd:PRK11551 55 AFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 139 FVREYCQEKQKAFFLSCLNSAMALGILLGSIVfliinaffSIEEIAAYAWRIAFFVGGIFGIISI-YLRRFLQETPVFKQ 217
Cdd:PRK11551 127 LTSEAVGPRLRGTAVSLMYCGVPFGGALASVI--------GVLAAGDAAWRHIFYVGGVGPLLLVpLLMRWLPESRAFAQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 218 MKKESSLSSFPLKDLFKEKDIvknlfSSMMMTWVLTGC-VIVLVLLMpKFMPSIL---NLSGVEGSYLQILGILGIALGG 293
Cdd:PRK11551 199 AAGAGKQRAPVLRALFGEGRA-----TATLLLWISYFFtLIVLYFLL-NWLPSLLvgqGLSRSQAGLVQIAFNIGGALGS 272
|
250
....*....|.
gi 919291524 294 AFMGYLVDKFG 304
Cdd:PRK11551 273 LLIGALMDRLR 283
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
59-425 |
2.58e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.99 E-value: 2.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 59 AFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPgyetlgflAPVLLILIRIFQGIAIGGELPGAWV 138
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT--------SYWQLLLARFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 139 FVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIInaffsieeIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQM 218
Cdd:cd17325 108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL--------ADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 219 KKESSLSSFPLKDLFKEKDivKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGY 298
Cdd:cd17325 180 KRAVSAARLRSGLRLLLRD--RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 299 LVDKFGlFKICIFFSLTFVFFSFLYFYALYELKNLVLVCILYSIICFLGGINVFApiLMSEVFRAKIRFSGISFsYNISY 378
Cdd:cd17325 258 LSDRIG-RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA--LLADIVPPEGRGTAMGL-FNTAF 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 919291524 379 AISGGITPQLVFWLNTlasknenpfLYGMSIYMIFLALLAICAVFIV 425
Cdd:cd17325 334 SLGMVLGPLLGGFLYD---------AFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
59-339 |
4.65e-12 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 67.19 E-value: 4.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 59 AFAAGYLarpLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYEtlgflapvLLILIRIFQGIAIGGELPGAWV 138
Cdd:cd17324 42 AYALGYA---LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 139 FVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAFFSieeiaayaWRIAFFVGGIFGIISIYLRRFLqeTPVFKQM 218
Cdd:cd17324 111 YAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG--------WRAAFLAIAVLALLAALLLWRL--LPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 219 KKESSLSSFPLKDLFKEkdivKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGY 298
Cdd:cd17324 181 KPGSLGLLSSLLLLLRN----PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 919291524 299 LVDKFGLFKICIFFSLTFVFFSFLYFYALYELKNLVLVCIL 339
Cdd:cd17324 257 LADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLW 297
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
61-323 |
1.01e-11 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 66.64 E-value: 1.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 61 AAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLgFLApvlliliRIFQGIAIGGELPGAWVFV 140
Cdd:PRK03893 62 SAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTL-FIA-------RLVIGMGMAGEYGSSATYV 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 141 RE----YCQEKQKAFFLsclnSAMALGILLGSIVFLIInaffsieeIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFK 216
Cdd:PRK03893 134 IEswpkHLRNKASGFLI----SGFSIGAVVAAQVYSLV--------VPVWGWRALFFIGILPIIFALWLRKNLPEAEDWK 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 217 QMKKESSlssfplkdlfKEKDIVKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVegsylqilGILGIALGGAFM 296
Cdd:PRK03893 202 EKHAGKA----------PVRTMVDILYRGEHRIINILLTLAAAAALWFCFAGNLQNAAIV--------AVLGLLCAAIFI 263
|
250 260
....*....|....*....|....*...
gi 919291524 297 GYLVDKFG-LFKICIFFSLTfVFFSFLY 323
Cdd:PRK03893 264 SFMVQSSGkRWPTGVMLMVV-VLFAFLY 290
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
62-430 |
1.76e-11 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 65.72 E-value: 1.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 62 AGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYetlgflapVLLILIRIFQGIAIGGELPGAWVFVR 141
Cdd:PRK12307 61 AAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAV 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 142 E----YCQEKQKAFFLSclnsamalGILLGSivflIINAFFSIEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQ 217
Cdd:PRK12307 133 EswpkHLKSKASAFLVS--------GFGIGN----IIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 218 MK---------KESSLSSFPLKDLFKekdivKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVEG---SYLQILG 285
Cdd:PRK12307 201 AKlsgkgkhsqSAWSVFSLSMKGLFN-----RAQFPLTLCVFIVLFSIFGANWPIFGLLPTYLAGEGFDTgvvSNLMTAA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 286 ILGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELKNLVLVCiLYSIICFLGGINVFAPILMSEVFRAKI 365
Cdd:PRK12307 276 AFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYLLLGAC-LFGLMATNVGVGGLVPKFLYDYFPLEV 354
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 919291524 366 RFSGISFSYNISyAISGGITPQLVFWLNTLASKNENPFLygmsIYMIFLALLAICAVFIVKDKIK 430
Cdd:PRK12307 355 RGLGTGLIYNLA-ATSGTFNSMAATWLGITMGLGAALTF----IVAFWTATILLIIGLSIPDRLK 414
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
56-425 |
1.18e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 62.59 E-value: 1.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 56 TYGAFAAGYLarpLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETlgflapvlLILIRIFQGIAIGGELPG 135
Cdd:cd17320 39 TLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAAAGSVV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 136 AWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAFFSieeiaayaWRIAFFVGGIFGIIS-IYLRRFLQETPv 214
Cdd:cd17320 108 ARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFG--------WRAIFVFLALLGLLLlLLVLLFLPETL- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 215 fKQMKKESSLSSFP--LKDLFKEkdivKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALG 292
Cdd:cd17320 179 -PEEKRKPLLSSLLraYKRVLKN----RRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 293 GAFMGYLVDKFGLFKIcIFFSLTFVFFSFLYFYALYELKNLVLVCILYSIICFLGGINVFAPILMS---EVFRaKIRFSG 369
Cdd:cd17320 254 SLLNGRLVRRFGPRRL-LRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSlalEPFP-HVAGTA 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 919291524 370 ISFSYNISYAISGGITPQLVFWLNTLASKnenpflygMSIYMIFLALLAICAVFIV 425
Cdd:cd17320 332 SALLGFLQFLIGALAGALVGLLPNGTALP--------MGLLILVLGLLALLLLILL 379
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
59-424 |
2.72e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 61.87 E-value: 2.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 59 AFAAGYLarpLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYEtlgflapvLLILIRIFQGIAIGGELPGAWV 138
Cdd:cd17328 42 VFIISYM---VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW--------QLLLFRALVGIGEASYSPIAPT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 139 FVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAffsieeiAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQM 218
Cdd:cd17328 111 IIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQ-------ATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 219 KKESSLSSFP------LKDLFKEKDIVKNLFSSMMMTWVLTGcvivLVLLMPKFMPSILNL----SGVEGSYLQILGILG 288
Cdd:cd17328 184 EGGVMAKSTAtsfladLKALAKNPSFILSTLGFTAVSFVTGA----LAFWAPTFFLRAFGVgdlsSADVGLIFGAITCIA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 289 IALGGAFMGYLVDKFGLF------KICIFFSLTFVFFSFLYFYAlyELKNLVLVCILYSIICFLGGIN---VFApILMSE 359
Cdd:cd17328 260 GVLGVLLGGILADRLRRKtpradpLVCAVGLLAAAPFLFLALVL--ALSNLLLAWVLLFLGEFLLSLNwapVFA-ILLYV 336
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 360 VfRAKIRFSGISFSYNISYAISGGITPQLVFWLNTLASKNENPFLYGM-----SIYMIFLALLAICAVFI 424
Cdd:cd17328 337 V-IPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNKDSPLAEAaslqyALLLCSFVLVLGGFFFL 405
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
3-416 |
5.49e-10 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 61.28 E-value: 5.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 3 KSKFETKEIKILGLSSLGGTLEFYDFIIFVFFAEYIANVFFPKDMSefwALLNTYGAF-AAGYLARPLGGIVMAHFGDKF 81
Cdd:TIGR00887 7 TAPFGWQHFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGP---LPSSVSAAVnGSASIGTLAGQLFFGWLADKL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 82 GRKNMFMLSILLMVLPTFVLAFIPGYETLGFLApvLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMA 161
Cdd:TIGR00887 84 GRKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 162 LGILLGSIVFLIINAFF--SIEEIAAYA-------------WRIAFFVGGIFGIISIYLRRFLQETP-----VFKQMKKE 221
Cdd:TIGR00887 162 FGILAGAIVALIVLAGFkhSLEAAADEAsctgscvpavdymWRILIGFGAVPALLALYFRLTIPETPrytadVAKDVEQA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 222 SS-LSSFPLKDLFKEKDIVKNLFSSM--------------------------MMTWVLTGCVIVLVLLMPK-------FM 267
Cdd:TIGR00887 242 ASdMSAVLQVKIEAEPDEVEKASTAVevpkaswsdffthffkwrhgkhllgtAGSWFLLDIAFYGVNLNQKvilsaigYS 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 268 PSILNLSGVEGSYLQILGILGIALGGAFMGY-----LVDKFGLFKICI--FFSLTFVFFSFLYFYALYELKNLVlvcILY 340
Cdd:TIGR00887 322 PPAATNNAYEELYKTAVGNLIIALAGTVPGYwvtvfLVDIIGRKPIQLmgFFILTVLFFVLGFAYNHLSTHGFL---AIY 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 341 SIICFLG--GINVFAPILMSEVFRAKIRfsgiSFSYNISYAIS--GGITPQLVFwlNTLA----SKNENPFLYGMSIYMI 412
Cdd:TIGR00887 399 VLAQFFAnfGPNATTFIVPGEVFPTRYR----STAHGISAASGkaGAIIGQFGF--LYLAqhgdPTKGYPTGIWMGHVLE 472
|
....
gi 919291524 413 FLAL 416
Cdd:TIGR00887 473 IFAL 476
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
65-425 |
8.68e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 60.30 E-value: 8.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 65 LARPLGGIVMAHFGDKFGRKNMFML-SILLMVLPTFVLAFIPGYETLGFL--APVLLILIRIFQGI------AIGGELpg 135
Cdd:COG2211 61 ITDPLIGALSDRTRTRWGRRRPWILiGAIPLALSFVLLFTAPDLSPTGKLiyALVTYLLLGLAYTLvnipysALGAEL-- 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 136 awvfVREYcqeKQKAFFLSCLNSAMALGILLGSIVFLIINAFFSieEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVF 215
Cdd:COG2211 139 ----TPDY---EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFG--GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPV 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 216 KQMKKESSLSSFplKDLFKEKDIVKnLFSSMMMTWVLTGCVIVLVLLmpkFMPSILNLSGVEGSYLQILGILGIALGGAF 295
Cdd:COG2211 210 PEEEKVSLKESL--KALLKNRPFLL-LLLAYLLFFLALALVAALLLY---YFKYVLGLSAALVGLLLALYFLAALLGAPL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 296 MGYLVDKFGLFKICIFFSLTFVFFSFLYFyaLYELKNLVLVCILYSIICF-LGGINVFAPILMSEV-----FRAKIRFSG 369
Cdd:COG2211 284 WPRLAKRFGKKKAFIIGLLLAALGLLLLF--FLGPGNLWLLLVLAALAGIgLGAILVLPWAMLADVvdydeWKTGRRREG 361
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 919291524 370 ISFS-YNISYAISGGITPQLVFWLNTLASKNENPFLYGMSIYMIFLALLAICAVFIV 425
Cdd:COG2211 362 LYFGiFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLL 418
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
72-425 |
9.85e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 59.88 E-value: 9.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 72 IVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGyetlgflaPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAF 151
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 152 FLSCLNSAMALGILLGSIVFLIINAFFSieeiaayaWRIAFFVGGIFGIISIYLrrflqetpvfkqmkkesslssfplkd 231
Cdd:cd17321 121 ALGLWGAVVGIGAALGPLLGGLLLELFG--------WRWIFLINVPIGLVALLL-------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 232 lfkekdiVKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGlFKICIF 311
Cdd:cd17321 167 -------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG-PRLVLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 312 FSLTFVFFSFLyFYALYELKNLVLVCILYSIICFLGGINVFAPI---LMSEVFRAK----------IRFSGISFSYNISY 378
Cdd:cd17321 239 AGLLLTAVGLL-LLALLGADSSVWLLLPGLVLLGLGLGLFATPLtnaALSSVPKEKagaasgilntARQLGGALGVALLG 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 919291524 379 AISGGITPQLVFWLN--TLASKNENPFLYGMSIYMIFLALLAICAVFIV 425
Cdd:cd17321 318 ALLTAGLSANLGDSGvaALLSAAAAAFAAGFHLAFLVAAALALLAALLA 366
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
77-397 |
7.27e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 56.80 E-value: 7.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 77 FGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLgflapvllILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCL 156
Cdd:cd17502 53 LSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTML--------IVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 157 NSAMALGILLGSIVFLIINAFFSieeiaayaWRIAFFVGGIFGIISIYlrrflqetpvfkqmkkesslssfplkdlfkek 236
Cdd:cd17502 125 GAVFGIASVAGPLIGGAFTDHLS--------WRWCFYINLPIGGLALA-------------------------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 237 dIVKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIFFSLTF 316
Cdd:cd17502 165 -LLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTIL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 317 VFFSFLYFYALYELKNLVLVcILYSIICFLGGINVFAPILMSEVFRAKIRFSGI-----SFSYNISYAIsgGITPQLVFW 391
Cdd:cd17502 244 MSVGAGLLTTLTLDTSKWLL-IGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVatatnTFFRSLGGTL--GVAITDVFL 320
|
....*.
gi 919291524 392 LNTLAS 397
Cdd:cd17502 321 VALALA 326
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
73-424 |
7.94e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 54.12 E-value: 7.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 73 VMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETlgflapvlLILIRIFQGIAiGGELPGAWVFVREYCQEKQKAFF 152
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV--------LIAGRALQGIG-GAVFPLAFALVREEFPPERVPVA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 153 LSCLNSAMALGILLGSIVFLIINAFFSieeiaayaWRIAFFVGGIFGIISIYLrrflqetpvfkqmkkesslssFPLKD- 231
Cdd:cd17504 121 QGILSATFGIGAGIGLPLGGWIVQHLG--------WRWIFWTAAPVAVLLAAL---------------------VPLIDl 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 232 -LFKEKDIVKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICI 310
Cdd:cd17504 172 rLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 311 FFSLTFVFFSFLYFYALYELknlvLVCILYSIICFLGGINVFAPILMSEVFRAKIRFSGISFSYN---------ISYAIS 381
Cdd:cd17504 252 IGLVISAVGLLLLALLHSSL----WALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNtvlrtigsaIGPAIA 327
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 919291524 382 GGITPQLVFWLNTLASKNENPFLYGMSIYMIFLALLAICAVFI 424
Cdd:cd17504 328 GAILTTYTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
58-425 |
1.56e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 52.96 E-value: 1.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 58 GAFAAGYLarpLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGyetlgflaPVLLILIRIFQGIAIGGELPGAW 137
Cdd:cd17319 45 SAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS--------LTSLYVLRFLLGVAEAGFFPGAI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 138 VFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIInaffsieeIAAYAWRIAFFVGGIFGIIsiylrrflqetpvfkq 217
Cdd:cd17319 114 KALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL--------LLLFGWRWAFIIEGLLGLL---------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 218 mkkesslssFPLKDLFKEKDIVKNLFSSMMMTWVLTGcvivLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMG 297
Cdd:cd17319 170 ---------LAVLWWFYLRQVWGLALGYFGINYALYG----LLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 298 YLVDKFGLFK----ICIFFSLTFVFFSFLYFyalyeLKNLVLVCILYSI-ICFLGGINVFAPILMSEVFRAKIRFSGISF 372
Cdd:cd17319 237 RLSDRLLRGArrlvIIIGLLLAAVGLLLAYL-----TTSPVVAVILLSLaGFGIGAASPVFWSLPADLLPGEAAATAGGL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 919291524 373 sYNISYAISGGITPQLVFWLNTlasknenpFLYGMSIYMIFLALLAICAVFIV 425
Cdd:cd17319 312 -INSGGNLGGFVAPLLIGYLVD--------ATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
69-424 |
4.34e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 51.88 E-value: 4.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 69 LGGIVMAHFGDKFGRKNMFMLSILLMVLP---TFVLAFIPGYEtlgflapvLLILIRIFQGIAIGGELPGAWVFVREYCQ 145
Cdd:cd17357 64 IGSFISAFLANRFGRKNGLLISNALLVVSsllMFLSKSAKSPE--------LLIFGRFLVGIACGLSTGFVPMYLQEISP 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 146 EKQKAFFLSCLNSAMALGILLGSIvfliinafFSIEEI--AAYAWRIAFFVGGIFGIISIYLRRFLQETP---------- 213
Cdd:cd17357 136 SELRGALGSLTQIGVTLGILLGQV--------FGLPSVlgTETLWPYLLFFPGIPALLQLAALPFFPESPkflliskgde 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 214 -------------------VFKQMKKES----SLSSFPLKDLFKEKDIVKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSI 270
Cdd:cd17357 208 eeaekslkflrgieddvdqELEEIKKESeqmgDQKQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFEN 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 271 LNLSGVEGSYLQILGILGIALGGAFMGYLVDKFG-------LFKICIFFSLTFVFFSFLyFYALYELKNLVLVCILYSII 343
Cdd:cd17357 288 AGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGrrpllliSLSVCAVALLLMSVFLFL-SEQNSWMSYGCIVAIFLFIF 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 344 CFLGGINVFAPILMSEVFRAKIRFSGISFSYNISYA---ISGGITPQLVfwlntlasknenpFLYGMSIYMIFLALLAIC 420
Cdd:cd17357 367 FFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTsnfIVGMAFPPLQ-------------SIGGGFVFIIFAIPCALF 433
|
....
gi 919291524 421 AVFI 424
Cdd:cd17357 434 LLYL 437
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
69-373 |
9.87e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 47.56 E-value: 9.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 69 LGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYetlgflapVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQ 148
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNF--------TIFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 149 KAFFLSCLNSAMALGILLGSIVFLIINAFFSIEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKKESSLSSFP 228
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGKPILIIGI 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 229 LKDLFKEkdivknlfssmmmtwvLTGCVIVLVllmpkFMPSILNLSGV--EGSYLQILGILGIALGGAFMG-YLVDKFGL 305
Cdd:cd17359 203 GLAIFQQ----------------FVGINVIFY-----YGPEIFQNAGFseNAALLQTIGIGVVNVIFTIIAiLLVDKVGR 261
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 919291524 306 FKICIFFSLTFVFFSFLYFYALYELKN------LVLVCILYSIICFLGGINVFAPILMSEVFRAKIRFSGISFS 373
Cdd:cd17359 262 KPLLLIGSIGMAISLLLIGTAFYFAPGsqasgiVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIA 335
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
38-355 |
9.92e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.57 E-value: 9.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 38 IANVFFPKDMSEFWALLNTYGAFAAGYLarpLGGIVM----AHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLgfl 113
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITSYL---LALAIMiplsGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL--- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 114 apvllILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAFFSieeiaayaWRIAFF 193
Cdd:cd17503 88 -----IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLS--------WRWIFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 194 VGGIFGIISIYLRRFLQetpvfkqmkkesslssfplKDLFKekdiVKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSILNL 273
Cdd:cd17503 155 INLPIGILALLLAPLLD-------------------LRLFK----DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 274 SGVEGSYLQILGILGIALGGAFMGYLVDKFGlFKICIFFSLTFVFFSFLYFYALYELKNLVLVCILYSIICFLGGInVFA 353
Cdd:cd17503 212 SAFESGLVLAPGGLASAILSPLVGRLLDKFG-PRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGL-VFM 289
|
..
gi 919291524 354 PI 355
Cdd:cd17503 290 PL 291
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
64-215 |
1.36e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 47.66 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 64 YLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETlgflapvlLILIRIFQGIAIGGELPGAWVFVREY 143
Cdd:TIGR01299 212 YLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGF--------FLFCRLLSGFGIGGAIPIVFSYFAEF 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 919291524 144 CQEKQKAFFLSCLNSA-MALGILLGSIVFLIINAF-FSIEEIAAY---AWRIAFFVGGIFGIISIYLRRFLQETPVF 215
Cdd:TIGR01299 284 LAQEKRGEHLSWLCMFwMIGGIYAAAMAWAIIPHYgWSFQMGSAYqfhSWRVFVIVCAFPCVFAIGALTFMPESPRF 360
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
64-215 |
2.51e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 46.45 E-value: 2.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 64 YLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYEtlgflapvLLILIRIFQGIAIGGELPGAWVFVREY 143
Cdd:cd17438 44 YLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEF 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 919291524 144 CQEKQKAFFLSCLNSAMALGILLGSIV-FLIINAF---FSI-EEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVF 215
Cdd:cd17438 116 LAREKRGEHLSWLCMFWMIGGLYASAMaWSIIPHYgwgFSMgTNYHFHSWRVFVIICALPCIASIIALKFMPESPRF 192
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
69-423 |
1.40e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.72 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 69 LGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYEtlgflapvLLILIRIFQGIAIGGELPGAWVFVREYCQEKQ 148
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY--------ALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 149 KAFFLSCLNSAMAlgilLGSIVFLIINAFfsieeIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKKESSLSSFP 228
Cdd:cd17473 122 RAKMLGLQSAAMS----LGGVVFLLLGGA-----LAEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 229 LKDLFKEKDIVKNLFSSMMMTWvltgcviVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGlFKI 308
Cdd:cd17473 193 ALPWKRVLPIYFLAFLAMLLFY-------VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLG-KRR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 309 CIFFSLTFVFFSFLYFYALYELKNLVLVCILYSIICFLGGINVFAPILMSEVFRAKIRFSGIsfsYNISYAISGGITPQL 388
Cdd:cd17473 265 LLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI---VTSAFFLGQFLSPLV 341
|
330 340 350
....*....|....*....|....*....|....*
gi 919291524 389 VFWLNTLASKNENPFLygmsIYMIFLALLAICAVF 423
Cdd:cd17473 342 LGPLVNLTGGLSGAFL----ILGVLALVLAIVLLL 372
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
62-345 |
1.55e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.77 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 62 AGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLGflapVLLILIrifqGIAIGGELPGAWVFVR 141
Cdd:cd17475 39 ALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLL----VLLFLV----GAGYGSVQPGGGRAIM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 142 EYCQEKQKAFFLSCLNSAMALGILLGSIVFLIInaffsieeIAAYAWRIAFFVGGIFGIIS-IYLRRFLQETPVFKQMKK 220
Cdd:cd17475 111 RWFPPRERGLAMGIRQTGVPLGGALAAALLPPL--------ALHYGWRAAFVVAGLVSILAaVLFWLFYREPPAASAATE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 221 ESSLSSFPLKDLFKEKDIVKNLFSSMMMTwvlTGCVIVLVLLMPkFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLV 300
Cdd:cd17475 183 SASTLLRSLKEVLRNRDVWLIAIAGALLV---APQFALLTFLLL-FLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVS 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 919291524 301 DKFG-------LFKICIFFSLTFVFFSFLYFYALYELknLVLVCILYSIICF 345
Cdd:cd17475 259 DRVFggrrrpvLVITAAIAAAALLVLSLLSPGTPLWL--LVLLLILLGLFAI 308
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
30-335 |
1.85e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.41 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 30 IFVFFAEYIANV-FFPKDMSEFWALLNTYGAFAAGYLARPLGGIvmahFGDKFGRKNMFMLSILLMVLPTFVLAFIPGye 108
Cdd:cd17391 15 IAPFLPLYIEQLgVTSGGLVELWSGLAFSSTFLVSAIFSPIWGR----LADRYGRKPMLLRASLGMAIVIGLMAFVTN-- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 109 tlgflAPVLLILiRIFQGIaIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAFFSIeeiaayaw 188
Cdd:cd17391 89 -----VWQLLIL-RLLQGV-FSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGI-------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 189 RIAFFVGGIFGIISIYLRRFLQETPvFKQMKKESSLSSFPLKDLFKEKDIVKNLF-SSMMMTWVLTGCVIVLVLLMPKFM 267
Cdd:cd17391 154 RNVFFITGGLLFLAFLLTLFFVKED-FKPVEKKKMVSTKEVWNSVPNPSLLISLFvTTFIIQLANQSIEPILTLYIRQLM 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 919291524 268 PSILNLSGVEGSYLQILGiLGIALGGAFMGYLVDKFGLFKICIFFSLTFVFFSFLYFYALYELKNLVL 335
Cdd:cd17391 233 GDASNLAFISGLVFSATG-VSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGIL 299
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
64-215 |
3.10e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 43.10 E-value: 3.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 64 YLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLGFlapvllilIRIFQGIAIGGELPGAWVFVREY 143
Cdd:cd17439 44 YLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLF--------CRLLSGVGIGGSIPIVFSYFSEF 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 919291524 144 CQEKQKAFFLSCLNSA-MALGILLGSIVFLIINAF-FSIEEIAAY---AWRIAFFVGGIFGIISIYLRRFLQETPVF 215
Cdd:cd17439 116 LAQEKRGEHLSWLCMFwMIGGIYASAMAWAIIPHYgWSFQMGSAYqfhSWRVFVLVCAFPSVFAIGALTTMPESPRF 192
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
36-423 |
3.28e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 42.70 E-value: 3.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 36 EYIANVFFPKDMSEF-------WALLNTYGAFAAGYLarpLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYe 108
Cdd:TIGR00898 105 EYSYDTFSSTIVTEWdlvcedaWKVDLTQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY- 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 109 tlgflaPVLLILiRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVfliinaffsieeiaAYA- 187
Cdd:TIGR00898 181 ------TVFLVF-RLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLV--------------AYFi 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 188 --WRIAFFVGGIFGIISIYLRRFLQETPVF---------------------------------KQMKKESSLSSFPLKDL 232
Cdd:TIGR00898 240 pdWRWLQLAVSLPTFLFFLLSWFVPESPRWlisqgrieealkilqriakingkklpaevlslsLEKDLSSSKKQYSFLDL 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 233 FKEKDIVKNLFSSMMMtWVLTGCVIV-LVLLMPKFMPSIlnlsgvegsYLQILGILGIALGGAFMGYL-VDKFGLFKICI 310
Cdd:TIGR00898 320 FRTPNLRKTTLCLMML-WFTTAFSYYgLVLDLGNLGGNI---------YLDLFISGLVELPAKLITLLlIDRLGRRYTMA 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 311 FFSLTFVFFSFLYFYALYELKNLVLVCILYSIICFLGGINVfAPILMSEVFRAKIRFSGISFSYNISyAISGGITPQLVF 390
Cdd:TIGR00898 390 ASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQM-VYLYTAELYPTVVRNLGVGVCSTMA-RVGSIISPFLVY 467
|
410 420 430
....*....|....*....|....*....|....*
gi 919291524 391 wlntLASKneNPFLYgmsiYMIF--LALLAICAVF 423
Cdd:TIGR00898 468 ----LGEK--WLFLP----LVLFggLALLAGILTL 492
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
58-209 |
4.37e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 42.16 E-value: 4.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 58 GAFAAGYLarpLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETlgflapVLLILIRIFQGIAIGGELPG-A 136
Cdd:cd17380 41 SSFFWGYA---LTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSL------PLLILSRILLGLGEGVHFPSmT 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 919291524 137 WVFVReYCQEKQKAFFLSCLNSAMALGILLGSIVFLIInaffsieeIAAYAWRIAFFVGGIFGII-SIYLRRFL 209
Cdd:cd17380 112 SLFSR-WVPVSERSRAVSIVTAGSYLGTLLGGLIGPLL--------LEYYGWPSVFYFFGLLGLLwALVWLIYL 176
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
69-429 |
5.06e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.17 E-value: 5.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 69 LGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYetLGFLAPVLLILIrifqGIAIGGEL-PGawvFVREYCQEK 147
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--ALLLAGTALIGA----GIAVGNVLlPG---LIKRWFPDR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 148 QkAFFLSCLNSAMALGILLGSIVFLIInaffsieeIAAYAWRIAFFVGGIFGIISIYLRrflqeTPVFKQMKKESSLSSF 227
Cdd:COG2807 139 V-GLMTGLYTAAMGLGAALAAGLTVPL--------AAALGWRGALAVWALLALLALLLW-----LPLLRRRPAAAAAAPA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 228 PLKdlfkekdiVKNLFSSmMMTWVLT---GCVIVLVLLMPKFMPSILNLSGVE----GSYLQILGILGIAlGGAFMGYLV 300
Cdd:COG2807 205 AAS--------LRSLWRS-PLAWLLTlffGLQSLLYYAVVAWLPPILRDAGLSaataGLLLSLFQLAGIP-GSLLVPLLA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 301 DKFGLFKICIFFSLTFVFFSFLyFYALYELKNLVLVCILYSIicFLGGINVFAPILMSEVFRAK---IRFSGISFSynIS 377
Cdd:COG2807 275 DRLGDRRPLLLLLGLLGLAGLL-GLLLAPGSLPWLWAVLLGL--GQGGLFPLALTLIGLRARTPaeaAALSGMAQS--VG 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 919291524 378 YAISgGITPQLVFWLNTLAskneNPFLYGMSIYMIFLALLAICAVFIVKDKI 429
Cdd:COG2807 350 YLLA-ALGPLLVGALHDAT----GSWTAALLLLAALAVLMLVAGLLAGRPYV 396
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
72-366 |
5.10e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.17 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 72 IVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLgflapvllILIRIFQGIAIGGELPGAWVFVREYCQEKQKAF 151
Cdd:cd17474 52 PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL--------LAGRALQGIGAAGLGPLALTLIGDLFEGGERAK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 152 FLSCLNSAMALGILLGSIvfliINAFfsieeIAAYAWRIAFFVGGIFGIISIYLRRFLQEtPVFKQMKKESSLSSFPLKD 231
Cdd:cd17474 124 AMGLYEAALGLGIAVGPL----LGGL-----LAAISWRYPFFLLAALIPVAFLAILFLLP-EPKEKAKSSSATKLRDLKK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 232 LFKEKDIVKNLFSSMMMTWVLTGcviVLVLLmPKFMPSILNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICIF 311
Cdd:cd17474 194 ALRGRGLLTFLVSAFLYFFLYFA---FLTYL-PFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILV 269
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 919291524 312 FSLTFVFFSFLYFYALYELKNLVLVCILYSIicFLGGINVFAPILMSEVFRAKIR 366
Cdd:cd17474 270 IGLLLYALSLLLLGFVPSLALLLIAIVLFGL--GLGLNLPLLTTLVTELAPEEER 322
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
59-426 |
5.72e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 41.76 E-value: 5.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 59 AFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYetlgflapVLLILIRIFQGIAIGGELPGAWV 138
Cdd:COG0738 48 LLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 139 FVREyCQEKQKAFFLSCLNSAMALGILLGSIVF-LIINAFFSIeeiaayAWRIAFFVGGIFGIISIYLrRFLQETPVFKQ 217
Cdd:COG0738 120 YVAA-LGPETAASRLNLLHAFFSLGALLGPLLGgLLILLGLSL------SWHLPYLILAVLLLLLALL-FLRSKLPEIEE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 218 MKKESSLSSFPLKDLFKEkdivKNLFSSMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAFMG 297
Cdd:COG0738 192 EEEEAAGSAASLKSLLKN----PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 298 YLVDKFGLFKICIFFSLTFVFFSFLYFYALYelknlvLVCILYSIICFLGGINVFAPILMSEVFRAKIRFSGISFSYNIS 377
Cdd:COG0738 268 FLLKRFGPVRLLRLSALLAAVGLLLALLAPG------PWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLI 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 919291524 378 YAISGG-ITPQLVFWLNTLASknenpFLYGMSIYMIFLALLAICAVFIVK 426
Cdd:COG0738 342 MGIVGGaIGPPLIGFLADAFG-----LRAAFLVPLVCYLLILLLALALKR 386
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
16-373 |
6.27e-04 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 41.94 E-value: 6.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 16 LSSLGGTLEFYD-FIIFVFFAEYIANVFFPKDMSEFWALLNTYGAFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLm 94
Cdd:TIGR00879 32 IAAIGGLMFGYDtGVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALL- 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 95 vlptFVLAFIPGYETLGFLAPVLLILIRIFQGIAIGGELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILLGSIVflII 174
Cdd:TIGR00879 111 ----FVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGF--GS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 175 NAFFSIEEIAayaWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKKESSLSSFPLKDLFKE------------------- 235
Cdd:TIGR00879 185 GKVSLNNTLG---WRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTsgedkelldelelidikrs 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 236 -----------------KDIVKNLFSSMMMTWV--LTGCVIVLvllmpKFMPSILNLSGV--EGSYLQILGILGIALGGA 294
Cdd:TIGR00879 262 iekrsvqpswgslfsstRRIRRRLFLGVVLQWFqqFTGINAIM-----YYSPTIFENAGVstDHAFLVSIIVGAVNFAFT 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 295 FMG-YLVDKFG---LFKICI------FFSLTFVFFSFLYfYALYELKNLVLVCILYSIICFLGGINVFAPILMSEVFRAK 364
Cdd:TIGR00879 337 FVAiFLVDRFGrrpLLLIGAagmaicLFVLGILGASFVT-GSSKSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPLS 415
|
....*....
gi 919291524 365 IRFSGISFS 373
Cdd:TIGR00879 416 LRPKGISIA 424
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
59-349 |
6.42e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 6.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 59 AFAAGYLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGyetLGFLAPVLLILIRIFQGIAIGGELPGAWV 138
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAL---LGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 139 FVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIINAFFSIEeiaayawrIAFFVGGIFGIISIYLRRFLQETPVfkqm 218
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPG--------GAFAINALSFLLSALLLLFIRRPPP---- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 219 KKESSLSSFPLKDLFKEKDIVKN---LFSSMMMTWVLTGCVIVLVLLMPKFMPSILNLSGVEGSYLQILGILGIALGGAF 295
Cdd:cd06173 184 AAPGESSSLLLRDLREGLRYLRRsplLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL 263
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 919291524 296 MGYLVDKFGLFKICIFFSLTFVFFSFLYFYALyelkNLVLVCILYSIICFLGGI 349
Cdd:cd06173 264 LGRLSKRRRRGRLLLIGALLLGLALLVLGLSP----SLWLLLAALFLLGLAGGL 313
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
58-201 |
7.85e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.45 E-value: 7.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 58 GAFAAGYLARPLGGivmAHFGDKFGRKNMFMLSILLMVLPTFvlaFIPGYETLGFlapVLLILIRIFQGIAIGGELPGAW 137
Cdd:cd17318 63 SSFFYGYILTQIPG---GYLAEKYGAKRVLGYSILITALLTL---LTPLAARGGY---GALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 919291524 138 VFVREYCQEKQKAFFLSCLNSamalGILLGSIVFLIINAFFsieeIAAYAWRIAFFVGGIFGII 201
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYS----GSQFGTVIAMPLSGFL----CESLGWPSIFYIFGGLGLL 189
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
73-346 |
2.02e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.23 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 73 VMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLGFLAPVLLILIRIF--QGIAIGGELPGawvfvreycqeKQKA 150
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFhpEGARLASQAAG-----------GRRG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 151 FFLSCLNSAMALGILLGSIVFLIInaffsIEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKKESSLSSFPLK 230
Cdd:cd17478 119 LAMSIFSVGGNLGFALGPLIAAAL-----VALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 231 DLFkekdIVKNLFSSMMMTWVLTGCVIVLVLLMPKfmpsiLNLSGVEGSYLQILGILGIALGGAFMGYLVDKFGLFKICI 310
Cdd:cd17478 194 WRA----LLLLLIIVFLRSWVLSSLTTFLPFYLVQ-----RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVII 264
|
250 260 270
....*....|....*....|....*....|....*.
gi 919291524 311 FFSLTFVFFSFLYFYAlyelkNLVLVCILYSIICFL 346
Cdd:cd17478 265 ASLLLAAPFLLLFLLT-----PGIWSYILLVLAGFL 295
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
69-209 |
2.10e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.87 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 69 LGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYEtlgflapvLLILIRIFQGIAIGGELPGAWVFVREYCQEKQ 148
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 919291524 149 KAFFLSCLNSAMALGILLGSIVFLIINaffsieeiaayAWRIAFFVGGIFGIISIYLRRFL 209
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIR-----------DWRWLQLAISLPGLLFLLLLWWL 161
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
51-166 |
3.46e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 39.26 E-value: 3.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 51 WALLNTYGAFAAGYLarpLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYetlgflaPVLLILiRIFQGIAIG 130
Cdd:cd17379 33 WKLDLFQSSLNLGFL---IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY-------PWFLIF-RFLQGLFGK 101
|
90 100 110
....*....|....*....|....*....|....*.
gi 919291524 131 GELPGAWVFVREYCQEKQKAFFLSCLNSAMALGILL 166
Cdd:cd17379 102 GGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLI 137
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
58-426 |
4.20e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.09 E-value: 4.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 58 GAFAAGYLArplggivmahfgDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLgflapvllILIRIFQGIAIGGELPGAW 137
Cdd:cd17315 50 GSLFGGPLA------------DRFGRRKSLLIAAVLYVIGALLSALAPNVWVL--------IVGRFLLGLGVGLASVLVP 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 138 VFVREYCQEKQKAFFLSCLNSAMALGILLGSIVFLIInaffsiEEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVFkq 217
Cdd:cd17315 110 LYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLAL------SLSPPGWWRLMFALAAVPALLQLLLMFFLPESRAL-- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 218 mkkesslssfplkdlfkekdivknLFSSMM-MTWVLTGCVIVLVllmpkFMPSILNLSGVEGSYLQILGILGIA--LGGA 294
Cdd:cd17315 182 ------------------------LVGVGLqLLQQLTGINAVMY-----YAPTIFKSAGGGTASILASIIVGVVnlLATL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 295 FMGYLVDKFG---LFKICIF---FSLTFVFFSFLYFYALYELKNLVLVCILYSIICFLGGINVFAPILMSEVFRAKIRFS 368
Cdd:cd17315 233 VAIRLVDKVGrrpLLLIGFAgmaASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGK 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 919291524 369 GISFSYNISYAISGGITPQLVFWLNTLAsknenpflyGMSIYMIFLALLAICAVFIVK 426
Cdd:cd17315 313 GMAIATLVNWIFNFIVGLTFLIMVSTIG---------LAGVFIFFAAVCLLALVFVFF 361
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
64-215 |
4.97e-03 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 39.13 E-value: 4.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 64 YLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYEtlgflapvLLILIRIFQGIAIGGELPGAWVFVREY 143
Cdd:cd17440 44 YLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYG--------LFLFCRLLSGFGIGGAVPTVFSYFAEV 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 919291524 144 CQEKQKAFFLSCLNSA-MALGILLGSIVFLIINAF-FSIEEIAAY---AWRIAFFVGGIFGIISIYLRRFLQETPVF 215
Cdd:cd17440 116 LAREKRGEHLSWLCMFwMIGGIYASAMAWAIIPHYgWSFSMGSAYqfhSWRVFVIVCALPCVSSVVALTFMPESPRF 192
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
69-324 |
5.90e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.74 E-value: 5.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 69 LGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLgFLAPVLLILIRIFQgiaiggelpGAWVFVREYCQEKQ 148
Cdd:cd17331 50 VGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPML-FLSRLPSVFMHAMQ---------AAQMVVTDLTDPGE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 149 KAFFLSCLNSAMALGILLGSIVFLIINAFFSIeeiaayawRIAFFVGGIFGIISIYLRRFLQETPvFKQMKKESSLSSFP 228
Cdd:cd17331 120 RAAALGRLGLSYGIGMVVGSFLGGLLTKKFGE--------QAAALVAAVGSLLSIVLVILLIPSN-TKSKREKEAKESAS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 229 LKDLFKEKDIVKNL----FSSMMMTWVLTGCVIVLVLLM-PKFMPSILNLSGVEGSYLQ-ILGILGIALGGAFMGYLVDK 302
Cdd:cd17331 191 PPSVFNLKEILRLLrlpgVAFLLLVKLLSGLPIGMFQSMfSLVAMDFFGLTPEENGYLMsYAGVLGMVVQGLLVGPLTKR 270
|
250 260 270
....*....|....*....|....*....|.
gi 919291524 303 FGLFKICI---------FFSLTFVFFSFLYF 324
Cdd:cd17331 271 FGERSLLKlsvallaigYLLLAFVTTVWQLL 301
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
64-215 |
8.08e-03 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 38.24 E-value: 8.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 64 YLARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYETLGFLapvlliliRIFQGIAIGGELPGAWVFVREY 143
Cdd:cd17363 44 YLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFC--------RLLSGIGIGGSIPIVFSYFAEF 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 919291524 144 CQEKQKAFFLSCLNSA-MALGILLGSIVFLIINAF---FSI-EEIAAYAWRIAFFVGGIFGIISIYLRRFLQETPVF 215
Cdd:cd17363 116 LAREKRGEHLSWLCMFwMIGGLYASAMAWAIIPHYgwgFSMgTAYQFHSWRVFVIVCALPSVASVVALTFMPESPRF 192
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
65-373 |
9.19e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 38.33 E-value: 9.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 65 LARPLGGIVMAHFGDKFGRKNMFMLSILLMVLPTFVLAFIPGYEtlgflapvLLILIRIFQGIAIGGELPGAWVFVREYC 144
Cdd:cd17358 52 LGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVW--------MLYLGRFLAGFGGGAASVVVPVYIAEIA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 145 QEKQKAFFLSCLNSAMALGILLGSIVFLIINaffsieeiaayaWRIAFFVGGIFGIISIYLRRFLQETPVFKQMKK---- 220
Cdd:cd17358 124 PKNVRGALGSLNQLLVNIGILLGYVLGSFLP------------WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGreee 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 221 -ESSLSSFPLKD---------------------------LFKEKDIVKNLFSSM--MMTWVLTGCVIVLVllmpkFMPSI 270
Cdd:cd17358 192 aEKSLQFLRGKDadiskeaaeiqeelaelekeakessfsDLFQRKYLKPLVIGLglMLFQQLSGINAVIF-----YASSI 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919291524 271 LNLSGVEGSYLQILGILGIA--LGGAFMGYLVDKFGLfKICIFFSLTFVFFSFLYFYALYELKN----------LVLVCI 338
Cdd:cd17358 267 FDEAGSGLDPNTATIIIGVVqvVGTLVATLLVDRLGR-RPLLLVSAIGMGIGLLALGLYFYLQEhgallssvswLPLVGL 345
|
330 340 350
....*....|....*....|....*....|....*
gi 919291524 339 LYSIICFLGGINVFAPILMSEVFRAKIRFSGISFS 373
Cdd:cd17358 346 VIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLV 380
|
|
| |
