|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-448 |
5.66e-79 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 251.65 E-value: 5.66e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLNL 95
Cdd:cd13134 7 ALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 96 FLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLNT 175
Cdd:cd13134 87 LFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILNI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 176 ALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAEAAGQTEKGSRRRgsfRWKQYMAMLLPVLVCEFL 255
Cdd:cd13134 167 VGNYLLIFGWFGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKK---LLKKILKIGLPSAGEELS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 256 WSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYGLSGSLLLSV 335
Cdd:cd13134 244 YNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVAL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 336 LIILTSRLYAGIYQVGDSVKLLTAQILIAYALVAPFKVLNMILgGGIIRSGGRTKYVMFIDIIGTWIFGVPLGLFAAFTL 415
Cdd:cd13134 324 LLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVL-IGSLRAAGDARFPVLIGIISMWGISVPLAYLLGIVL 402
|
410 420 430
....*....|....*....|....*....|...
gi 916666795 416 KLEVPYVYFILSLEECVRFGISVLVFRKKRWMQ 448
Cdd:cd13134 403 GLGLLGVWIAFAADEWVRGIIMLWRWRSGKWIK 435
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
14-446 |
1.67e-66 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 219.31 E-value: 1.67e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 14 VCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLL 93
Cdd:cd13137 3 IWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 94 NLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALL 173
Cdd:cd13137 83 SLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 174 NTALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLRgaeaagqtEKGSRRRGSFRW-----KQYMAMLLP 248
Cdd:cd13137 163 NIVLDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGR--------LPIKISFKGFRLdrkiiKKLLRIGLP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 249 VLVCEFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYGLS 328
Cdd:cd13137 235 AGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 329 GSLLLSVLIILTSRLYAGIYQVGDSVKLLTAQILIAYALVAPFKVLNMILgGGIIRSGGRTKYVMFIDIIGTWIFGVPLG 408
Cdd:cd13137 315 FMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVL-SGALRGAGDTRPPLIINLISMWLVRLPLA 393
|
410 420 430
....*....|....*....|....*....|....*...
gi 916666795 409 LFAAFTLKLEVPYVYFILSLEECVRFGISVLVFRKKRW 446
Cdd:cd13137 394 YLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
16-439 |
2.26e-62 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 208.07 E-value: 2.26e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLNL 95
Cdd:COG0534 12 RLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVLGQAL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 96 FLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLNT 175
Cdd:COG0534 92 LLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 176 ALNYLLIFGkagfPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGaeaagqTEKGSRRRGSFRWKQYMAML---LPVLVC 252
Cdd:COG0534 172 VLDPLLIFG----GGLGVAGAALATVISQAVSALLLLYYLFRKRS------LLRLRLRDLRPDRKILKRILrigLPAGLQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 253 EFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYGLSGSLL 332
Cdd:COG0534 242 QLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 333 LSVLIILTSRLYAGIYQVGDSVKLLTAQILIAYALVAPFKVLNMILgGGIIRSGGRTKYVMFIDIIGTWIFGVPLGLFAA 412
Cdd:COG0534 322 LALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVL-SGALRGAGDTRFPMIISLLRLWLVRLPLAYLLA 400
|
410 420
....*....|....*....|....*..
gi 916666795 413 FtLKLEVPYVYFILSLEECVRFGISVL 439
Cdd:COG0534 401 F-LGLGLTGVWLALPIGEVLRALLLLL 426
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-446 |
1.13e-38 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 144.98 E-value: 1.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 14 VCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLL 93
Cdd:cd13133 7 ILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 94 NLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIiggsFLPLAGATLLSVLFRC----MEKARLPLYASIA 169
Cdd:cd13133 87 GLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRI----RILGAPFSLLGAALRAffsgIGRTRVVMVANLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 170 AALLNTALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAEAAgqtekGSRRRGSFRWKQYMAML--- 246
Cdd:cd13133 163 MVVVNIVLDYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRF-----GLRRAWRFDRELLRRILrlg 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 247 LPVLVCEFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYG 326
Cdd:cd13133 238 LPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 327 LSGSLLLSVLIILTSRLYAGIYQVGDSVKLLTAQILIAYALVA---PFKVLNMILgGGIIRSGGRTKYVMFIDIIGTWIF 403
Cdd:cd13133 318 LAYMLLLGILFLLFPELLLSIFTPGADFALIAELAVPLLRFVAayiLFDALALVF-AGALRGAGDTRFVMLAELIVAWLY 396
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 916666795 404 GVPLGLFaAFTLKLEVPYVYFILSLEECVRFGISVLVFRKKRW 446
Cdd:cd13133 397 LLPPAYL-LVVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
16-447 |
5.60e-37 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 140.29 E-value: 5.60e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQ-LGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLN 94
Cdd:cd13138 7 LFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGTL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 95 LFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLN 174
Cdd:cd13138 87 LVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACVLN 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 175 TALNYLLIFGkagfPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAeaagqtEKGSRRRGSFRWKQYMAML---LPVLV 251
Cdd:cd13138 167 IILDLLFIAV----FHMGVAGAALATVIAQAISVLLALYYLRKKKLP------FKLSLKDFRFDKEILKEILkigLPSAL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 252 CEFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYGLSGSL 331
Cdd:cd13138 237 QQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 332 LLSVLIILTSRLYAGIYQVGDSVKLLTAQILIAYALVAPFKVLNMILgGGIIRSGGRTKYVMFIDIIGTWIFGVPLGLFA 411
Cdd:cd13138 317 IIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVF-NGLFRGLGKTKFPMIISILRLWLVRIPLAYLL 395
|
410 420 430
....*....|....*....|....*....|....*.
gi 916666795 412 AFTLKLEVPYVYFILSLEECVRFGISVLVFRKKRWM 447
Cdd:cd13138 396 SRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
20-363 |
5.31e-34 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 130.44 E-value: 5.31e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 20 PVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLNLFLSL 99
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 100 GMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYL-FIIGGSFLPLAGATLLSVLfRCMEKARLPLYASIAAALLNTALN 178
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLrILILGIPAYLLNFVLRGFL-RGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 179 YLLIFGKAGFppMGERGAAAATLLSQGMNFLLMLFMFFRLRGAEAAGQTEKGSRRRGsfrWKQYMAMLLPVLVCEFLWSL 258
Cdd:TIGR00797 160 YILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEV---LKRLLKLGLPIAFRVILESL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 259 GENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYGLSGSLLLSVLII 338
Cdd:TIGR00797 235 SFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILI 314
|
330 340
....*....|....*....|....*
gi 916666795 339 LTSRLYAGIYQVGDSVKLLTAQILI 363
Cdd:TIGR00797 315 LFREFIARLFTNDPEVLELAAIYLI 339
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
16-417 |
1.05e-30 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 122.99 E-value: 1.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAgkfASIFSVVVS-AVGTVAGI--MISQYIGQKNRFEVRRSFL 92
Cdd:cd13131 7 RLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALG---SSLWFPVFTfGMGLLLAVtpLVAQAHGAGDRRRIRRAVR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 93 LNLFLSLGMAVLFsGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAAL 172
Cdd:cd13131 84 QGLWLALLLSLPL-MLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 173 LNTALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAEAAGQTEKGSRRRGSfRWKQYMAMLLPV--- 249
Cdd:cd13131 163 LNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFWRPDWA-RLKELLRLGLPIglt 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 250 LVCE---------FLWSLGEnvyTAIYGHMRTEASAAMILTGPIqglmigalcGLSQAAGVIVGKRLGNKDYKGAYAASK 320
Cdd:cd13131 242 IFFEvslfaavalLMGRLGT---TVLAAHQIALNFASLLFMVPL---------GISMAATVRVGFALGAGDPADARRAGL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 321 RLLLYGLSGSLLLSVLIILTSR--------------------LYAGIYQVGDSVKLLTAQILIAYalvapfkvlnmilgg 380
Cdd:cd13131 310 VGLGLGVGFAALTALLLLLFPEqiaglytndpavialaasllVFAALFQLFDGIQVVAAGALRGY--------------- 374
|
410 420 430
....*....|....*....|....*....|....*..
gi 916666795 381 giirsgGRTKYVMFIDIIGTWIFGVPLGLFAAFTLKL 417
Cdd:cd13131 375 ------KDTRVPFLLALISYWGIGLPLGYLLAFTTGL 405
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-448 |
2.42e-29 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 119.22 E-value: 2.42e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAgkFASIFSVVVSAVG-TVAG-IMISQYIGQKNRFEVRRSFLL 93
Cdd:cd13142 15 KLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSIS--WPLIFLFISLGGGlTVAGtALVAQYTGAGDYDKANKVAGQ 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 94 NLFLSLGMAVLFSGLCLFFPERIM-GLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAAL 172
Cdd:cd13142 93 TFSFVIILSLILAVLGYILSRPLLlLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIMFGSVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 173 LNTALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLRgaeaagQTEKGSRRRGSFRWKQYMAML---LPV 249
Cdd:cd13142 173 LNVILDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGR------VGLKISLRDLKPDWEWLKKIFrigLPS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 250 LVCEFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYGLSG 329
Cdd:cd13142 247 SIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 330 SLLLSVLIILTSRLYAGIYqVGDSVKLLTAQILIAYALVA-PFKVLnMILGGGIIRSGGRTKYVMFIDIIGTWIFGVPLG 408
Cdd:cd13142 327 LVIGGVLAFLFAEPIVRVF-INDPEVIKEGADFLRIVAPSfPFFGL-FQVINGAFRGSGHTLTAMIISILRLWVIRIPLA 404
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 916666795 409 LFAAFTLKLEVPYVYFILSLEECVRFGISVLVFRKKRWMQ 448
Cdd:cd13142 405 YLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
18-442 |
1.11e-28 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 117.04 E-value: 1.11e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 18 AVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLNLFL 97
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 98 SLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLNTAL 177
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 178 NYLLIFGKAGfPPMGERGAAAATLLSQGMNFLLMLFMFFRLRgaeaagqTEKGSRRRGSFRWKQYMAML----LPVLVCE 253
Cdd:cd12082 161 DPLLIFGLGP-PELGIAGAALATVISYVIGALLLLIYLRKGK-------KILKFKLSLLKPDLELLRRLlrigLPSAIQN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 254 FLWSLGENVYTAIYGHMR-TEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYGLSGSLL 332
Cdd:cd12082 233 SLLSLGLLIIVAIVAAFGgAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 333 LSVLIILTSRLYAGIYQVGDSVKLLTAQILIAYALVAPFKVLNMILgGGIIRSGGRTKYVMFIDIIGTWIFGVPLGLFAA 412
Cdd:cd12082 313 LGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVL-QAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLA 391
|
410 420 430
....*....|....*....|....*....|
gi 916666795 413 FtLKLEVPYVYFILSLEECVRFGISVLVFR 442
Cdd:cd12082 392 Y-LGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-443 |
1.59e-27 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 113.93 E-value: 1.59e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 17 LAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIA-GKFASIFSVVVSAVGTvAGIMISQYIGQKNRFEVRRSFLLNL 95
Cdd:cd13135 6 IAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVtTPFNTITGFLGSISIG-FTILGSQSVGAKDIKRINDYAISSI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 96 FLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLNT 175
Cdd:cd13135 85 VYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLNV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 176 ALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAeaagQTEKGSRRRGSFRWKQYMAML---LPVLVC 252
Cdd:cd13135 165 ILDYVLIFGNFGFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKL----TFKLSNTKVLKANIRPYKFTIklgLPLGGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 253 EFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYGLSGSLL 332
Cdd:cd13135 241 EFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 333 LSVLIILTSRLYAGIYQVGDSVKLLTAQILIAYALVAPFKVLNmILGGGIIRSGGRTKYVMFIDIIGTwIFGVPLGLFAA 412
Cdd:cd13135 321 AAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSIN-IVYGFAIRAIGDTKWMLYTQIIGT-IIVVSVALLLI 398
|
410 420 430
....*....|....*....|....*....|.
gi 916666795 413 FTLKLEVPYVYFILSLEECVRFGISVLVFRK 443
Cdd:cd13135 399 FVFKLGLAGVYITLFIDEIIRAIINFLKYRK 429
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-446 |
4.24e-25 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 106.84 E-value: 4.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGkFASIFSVVVSAVGTV-AGIMISQYIGQKNRFEVRRSFLLN 94
Cdd:cd13140 9 RLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAG-FFVWLAYALALLSKIgAQVKVSQSIGAKDEKEARKYARNA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 95 LFLSLGMAVLFSGLCLFFPERIMGLYT-KDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALL 173
Cdd:cd13140 88 LQLNLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 174 NTALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAEaagqteKGSRRRGSFRWKQYMAML---LPVL 250
Cdd:cd13140 168 NIILDPLLIFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKKKGLF------LKIRILKRPDRKYIKEILklgLPVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 251 VCEFLWSL---GENVYTAIYGHMrteASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKrlllygl 327
Cdd:cd13140 242 LQSILFALismILARIIASFGPV---AIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYK------- 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 328 sgslllsvliilTSRLYAGIYQVGDSVKLL---------------TAQILIAYALVAPFKVLNM---ILGGGIIRSGGRT 389
Cdd:cd13140 312 ------------TALKIASAIGLFATLLLFffgeplfslfipdpeTIAIGVDYLRILGFSQLFMcleITTTGAFNGLGRT 379
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 916666795 390 KYVMFIDIIGTwIFGVPLGLFAAFTLkLEVPYVYFILSLEECVRFGISVLVFRKKRW 446
Cdd:cd13140 380 KPPAIISIVFN-GLRIPLALLLSPTG-LGLNGIWWAISISSILKGIILTIWFLLYKK 434
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
20-180 |
1.76e-24 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 99.18 E-value: 1.76e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 20 PVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLNLFLSL 99
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 100 GMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLNTALNY 179
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 916666795 180 L 180
Cdd:pfam01554 161 L 161
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-446 |
3.30e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 104.62 E-value: 3.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 17 LAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLNLF 96
Cdd:cd13139 19 LAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAIL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 97 LSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLNTA 176
Cdd:cd13139 99 LGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGLNII 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 177 LNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAEAAGqtekgsRRRGSFRW---KQYMAMLLPVLVCE 253
Cdd:cd13139 179 LDPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIR------RRHLKLDWaiiKKIIKIAVGGILQF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 254 FLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYGLSGSLLL 333
Cdd:cd13139 253 LIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIV 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 334 SVLIILTSRLYAGIYQVGDSVKLLTAQILIAYALVAPFKVLNMILgGGIIRSGGRTKYVMFIDIIGTWIFGVPLGLFAAF 413
Cdd:cd13139 333 SLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVL-SQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLAR 411
|
410 420 430
....*....|....*....|....*....|...
gi 916666795 414 TLKLEVPYVYFILSLEECVRFGISVLVFRKKRW 446
Cdd:cd13139 412 HLNLGPKGVFIAIPIAETVLAIAAIILFRRGKW 444
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
14-419 |
7.07e-24 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 103.42 E-value: 7.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 14 VCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSV-VVSAVGTVAGIMISQYIGQKNRFEVRRSFL 92
Cdd:cd13132 5 LLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFsILLGLASALDTLCGQAFGAKNYKLVGVYLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 93 LNLFLSLGMAVLFSGLClFFPERIMGLYTKDPGVRRAAAGYLFIiggSFLPLAGATLLSVL---FRCMEKARLPLYASIA 169
Cdd:cd13132 85 RALVILLLCCVPISLLW-LNTEPILLLLGQDPEIARLAGEYLRW---LIPGLFAYALFEPLkryLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 170 AALLNTALNYLLIFGKAgfppMGERGAAAATLLSQgmnFLLMLFMFFRLRGAEAAGQTEKGSRRRGSFRWKQYMAMLLP- 248
Cdd:cd13132 161 ALLLNILLNYLLVFVLG----LGFIGAALATSISY---WLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPs 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 249 -VLVCEFLWSLgeNVYTAIYGHMRTEAS-AAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYG 326
Cdd:cd13132 234 aLMLCLEWWAF--EILVLLAGLLPGTVAlAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILS 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 327 LSGSLLLSVLIILTSRLYAGIYQVGDSVKLLTAQILIAYALVAPFKVLNMILGGGIIRSGGRtKYVMFIDIIGTWIFGVP 406
Cdd:cd13132 312 LVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQ-KLGAYVNLVAYYLIGLP 390
|
410
....*....|...
gi 916666795 407 LGLFAAFTLKLEV 419
Cdd:cd13132 391 VGLLLAFVLGLGL 403
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
2-214 |
1.58e-23 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 102.14 E-value: 1.58e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 2 RDRKEKHPFFASVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQ 81
Cdd:COG0534 219 RDLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGA 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 82 KNRFEVRRSFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKAR 161
Cdd:COG0534 299 GDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTR 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 916666795 162 LPLYASIAAA-LLNTALNYLLifgkaGFPPMGERGAAAATLLSQGMNFLLMLFM 214
Cdd:COG0534 379 FPMIISLLRLwLVRLPLAYLL-----AFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-219 |
7.36e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 97.30 E-value: 7.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 9 PFFASVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAgkFASIFSVVVSAVGTVAGI--MISQYIGQKNRFE 86
Cdd:cd13144 5 PVLRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLA--FPIQNLMIAVAVGTGVGVnaLLSRSLGEKDQKE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 87 VRRSFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYA 166
Cdd:cd13144 83 ANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIA 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 916666795 167 SIAAALLNTALNYLLIFGKAGFPPMGERGAAAATLLSQgmnFLLMLFMFFRLR 219
Cdd:cd13144 163 QLIGAIINIILDPILIFGLFGFPAMGIAGAAIATVIGQ---ILAMFLAFFFLL 212
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
16-320 |
3.66e-20 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 92.19 E-value: 3.66e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQL-GDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLN 94
Cdd:cd13143 8 KFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFSTA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 95 LFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLN 174
Cdd:cd13143 88 LLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 175 TALNYLLIFGkagfPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAeaagqtEKGSRRRGSFRWKqYMAMLLPVLVCEF 254
Cdd:cd13143 168 IILDPLFIFV----LGLGIAGAALATVIAQLISLLLLLLYFFRGKSL------LKLSLLRFKLSLK-IIKEILALGFPSF 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 916666795 255 LWSLGE-------NVYTAIYGHmrTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASK 320
Cdd:cd13143 237 LMQLSSsvvtivlNLTLLGYGG--DIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALK 307
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
2-219 |
3.47e-19 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 89.44 E-value: 3.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 2 RDRKEKHPFFASVCRLAVPVALQSILQS-SFSAVdQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIG 80
Cdd:cd13138 215 KDFRFDKEILKEILKIGLPSALQQSLVSiSFLII-NSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIG 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 81 QKNRFEVRRSFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKA 160
Cdd:cd13138 294 AGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKT 373
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 916666795 161 RLPLYASIAAALLntaLNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLR 219
Cdd:cd13138 374 KFPMIISILRLWL---VRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGR 429
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-320 |
1.24e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 84.66 E-value: 1.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 9 PFFASVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVR 88
Cdd:cd13149 6 SIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 89 RSFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFI--IGGSFL--PLAGATLLsvlfRCMEKARLPL 164
Cdd:cd13149 86 RLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIwyLGLVFLvlPMVGNAII----RATGDTKRPS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 165 YASIAAALLNTALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLML-FMFFRLRGAEaagqTEKGSRRRGSFRWKQYM 243
Cdd:cd13149 162 LVMLGAALVNVILDPILIFGFGPIPGMGIAGAAIATVISRALGLGAALyFLHYHHRLID----FSEPSLKALFRSWKDIL 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 916666795 244 AMLLPVLVCEFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASK 320
Cdd:cd13149 238 SIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLK 314
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
16-321 |
7.02e-17 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 82.22 E-value: 7.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQLGDVS-VAAVGIAgkfASIFSVVVS-----AVGTVAgiMISQYIGQKNRFEVRR 89
Cdd:cd13136 7 ALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALG---TTIFNTLFWlfgflRMGTTG--LVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 90 SFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFI-IGGSFLPLAGATLLSVlFRCMEKARLPLYASI 168
Cdd:cd13136 82 LLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIrILGAPAVLLNYVATGW-FRGLQDTRTPLILQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 169 AAALLNTALNYLLIFGKAgfppMGERGAAAATLLSQGMNFLLMLFMFFRLRGAEAAGQTEKGSRRRGsfrWKQYMAMLLP 248
Cdd:cd13136 161 VGNVVNIVLDPLFVFGLG----WGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAA---LKRLFKLNRD 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 916666795 249 VLVCEFLWSLGENVYTAIYGHMRTEASAA-MILtgpIQGLMIGALC--GLSQAAGVIVGKRLGNKDYKGAYAASKR 321
Cdd:cd13136 234 IFIRTLALLAAFLFFTALAARLGDVILAAnQIL---LQFWLLSSYFldGFAYAAEALVGRALGAGDRKAARRVARR 306
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-218 |
6.50e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 79.67 E-value: 6.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGkfaSIFSVVVSA-----VGTVAgiMISQYIGQKNRFEVRRS 90
Cdd:cd13141 15 SMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAG---NVMFFVMALtqvlnVGTAA--LVSHAVGRKDQGEANAV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 91 FLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFiiggSFLPLAGATLLSVLF----RCMEKARLPLYA 166
Cdd:cd13141 90 FNQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLY----WFIPSLALQFILTVLgaalRGTGIVKPFMVI 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 916666795 167 SIAAALLNTALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRL 218
Cdd:cd13141 166 QILAVLLNIILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLRL 217
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
11-218 |
5.12e-14 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 73.69 E-value: 5.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 11 FASVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRS 90
Cdd:cd13131 228 LKELLRLGLPIGLTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRA 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 91 FLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAA 170
Cdd:cd13131 308 GLVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALIS 387
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 916666795 171 -ALLNTALNYLLIFGKagfpPMGERGAAAATLLSQGMNFLLMLFMFFRL 218
Cdd:cd13131 388 yWGIGLPLGYLLAFTT----GLGAFGVWIGLIIGLALAAILLLWRFRRL 432
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
17-428 |
1.03e-13 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 72.92 E-value: 1.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 17 LAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAgkfASIF-SVVVSAVGTVAGI--MISQYIGQKNRFEVRRSFLL 93
Cdd:PRK01766 17 LALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIG---TSIWlPVILFGHGLLLALtpIVAQLNGAGRRERIAHQVRQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 94 NLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLagatLLSVLFRC----MEKARLPLYASIA 169
Cdd:PRK01766 94 GLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAY----LLYQVLRSfidgLGKTKPTMVIGFL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 170 AALLNTALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAEAAGQTEKGSRRRGSfRWKQYMAMLLPV 249
Cdd:PRK01766 170 GLLINIPLNYIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKPDWA-VIKRLLKLGLPI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 250 ---LVCEflwslgenvyTAIYghmrteaSAAMILTGPIQGLMIGA---------LC-----GLSQAAGVIVGKRLGNKDY 312
Cdd:PRK01766 249 glaIFFE----------VSLF-------AVVTLLVSPLGTVTVAAhqialnfssLLfmlplSLAMALTIRVGFELGAGRT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 313 KGAYAASkRLLLYGLSGSLLLSVLIILTSR---------------------LYAGIYQVGDSVklltaQILIAYALVApF 371
Cdd:PRK01766 312 LDARQYA-YIGLAVGLGMALLTAIFLVLFReqiallytddpevvalashllLFAALFQFSDAI-----QVIGSGALRG-Y 384
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 372 KVlnmilgggiirsggrTKYVMFIDIIGTWIFGVPLGLFAAFTLKLEvPYVY---FILSL 428
Cdd:PRK01766 385 KD---------------TRVIFFITFIAYWVLGLPLGYILALTDPMG-PFGFwigLIIGL 428
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
16-212 |
8.78e-13 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 69.21 E-value: 8.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQ-LGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLN 94
Cdd:COG2244 177 KYSLPLLLSGLLGLLLTNLDRLLLGAlLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKA 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 95 LFLSLGMAVLFSGLCLFFPERIMGLYTKDPgvRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLN 174
Cdd:COG2244 257 LRLLLLLGLPLALGLALLAPPLLSLLFGPE--YAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLN 334
|
170 180 190
....*....|....*....|....*....|....*...
gi 916666795 175 TALNYLLIfgkagfPPMGERGAAAATLLSQGMNFLLML 212
Cdd:COG2244 335 LVLNLLLI------PRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
16-215 |
9.35e-13 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 69.49 E-value: 9.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQ-LGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRfEVRRSFLLN 94
Cdd:cd13128 210 RFSIPLALSGIFSLIYTRIDTIMLGYfLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKNDKD-ELKKLLKKS 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 95 LFLSLGMAVLFSGLCLFFPERIMGL-YTKDPgvrRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALL 173
Cdd:cd13128 289 FKYLFLISLPIAIGLFLFAEPIITLlFGEEY---LPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALL 365
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 916666795 174 NTALNYLLIfgkagfPPMGERGAAAATLLSQGMNFLLMLFMF 215
Cdd:cd13128 366 NVILNLLLI------PKYGIIGAAIATLISEFIIFILLLYLL 401
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
10-158 |
1.58e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 69.09 E-value: 1.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 10 FFASVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRR 89
Cdd:cd13140 229 YIKEILKLGLPVALQSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRK 308
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 916666795 90 SFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGgsflplagatlLSVLFRCME 158
Cdd:cd13140 309 GYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILG-----------FSQLFMCLE 366
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-312 |
2.85e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 64.93 E-value: 2.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAgkFASIFSVVVSAVGTVAGI--MISQYIGQKNRFEVRRSFLL 93
Cdd:cd13145 13 KLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLS--FPIFFIIIAIGVGIGTGTtaLIGNALGAGDRRKARRYAAQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 94 NLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFII-GGSFLPLAGATLLSVL--------FRcmekarlpl 164
Cdd:cd13145 91 GLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIfAGSIFFLLNFGLNGILnaqgdtksYR--------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 165 YASIAAALLNTALNYLLIFGKAGFPPMGERGAAAATLLSQGMNfllMLFMFFRLRgaeaagQTEKGSRRRGSF------R 238
Cdd:cd13145 162 NFLIIGFFLNIILDPLFIFGGGGIPAMGVSGIALATIISQFIG---MFYLLYKVR------KSGIISGCRLRDfiprldV 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 916666795 239 WKQYMAMLLPVLVCEFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDY 312
Cdd:cd13145 233 YKEILKQGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKY 306
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
13-216 |
2.91e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 61.79 E-value: 2.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 13 SVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFL 92
Cdd:cd13147 10 AIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 93 LNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLfRCMEKARLPLYASIAAAL 172
Cdd:cd13147 90 HSILLGLIISIILTIVLLPFLEPILVLMGAGEVLDLAVDYGRIIFLGSIFLIFNNVAYGIL-RGEGDTKRAMYAMVAGSI 168
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 916666795 173 LNTALNYLLIFGkAGfppMGERGAAAATLLSQGMNFLLMLFMFF 216
Cdd:cd13147 169 LNIILDPIFIYT-LG---LGIAGAAWATVISMLISSLVLLYWFF 208
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
7-217 |
5.30e-10 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 60.93 E-value: 5.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 7 KHPFFASVCRLAVPVAL-QSILQSSFsAVDQIMIGQLGDVSVAAVGIAGKFASI-FSVVVSAVGTVAGIMISQYIGQKNR 84
Cdd:cd13123 210 RDPGVRRVLKLMLPALLgVSVSQINL-LVDTILASFLPEGSISALYYADRLYQLpLGIFGVAIATALLPRLSRLAAAGDL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 85 FEVRRSFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTK----DPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKA 160
Cdd:cd13123 289 DEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLFErgafTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDT 368
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 916666795 161 RLPLYASIAAALLNTALNYLLIFgkagfpPMGERGAAAATLLSQGMNFLLMLFMFFR 217
Cdd:cd13123 369 KTPVKIAVIAVAVNILLNLLLIK------PLGHVGLALATSLSAWVNALLLLVLLRR 419
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-150 |
4.33e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 58.31 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 11 FASVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRS 90
Cdd:cd13133 230 LRRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRV 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 916666795 91 FLLNLFLSLGMAVLFSGLCLFFPERIMGLYT--KDPGVRRAAAGYLFIIGGSFLPLAGATLL 150
Cdd:cd13133 310 TRRGLKLALAYMLLLGILFLLFPELLLSIFTpgADFALIAELAVPLLRFVAAYILFDALALV 371
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
2-218 |
3.79e-08 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 55.17 E-value: 3.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 2 RDRKEKHPFFASVCRLAVPVALQSILQSSFSAVDQIMIGQL-----GDVSVAAV------GIAGKFASIFSVVVSAVGTV 70
Cdd:cd13124 214 RSKISTKEILKELLSYAIPITLSSLILPLLQLIDSFTVPRRlqaagLSESEATAlygiltGRAQPLVQLPTVIATALSTS 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 71 AGIMISQYIGQKNRFEVRRSFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPgvrrAAAGYLFIIGGSFLPLAGATLL 150
Cdd:cd13124 294 LVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDS----EGGLILQILAPSILFLSLQQVT 369
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 916666795 151 SVLFRCMEKARLPLYASIAAALLNTALNYLLIfgkagfPPMGERGAAAATLLSQGMNFLLMLFMFFRL 218
Cdd:cd13124 370 AAILQGLGKVKIPVINLLIGLLVKIVLNYVLI------PIFGIYGAAIATVIGFLVAALLNLRALKKL 431
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
7-258 |
3.83e-08 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 55.54 E-value: 3.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 7 KHPFFASVCRLAVPVAL-QSILQSSFsAVDQIMIGQLGDVSVAAVGIAGKFASI-FSVVVSAVGTVAGIMISQYIGQKNR 84
Cdd:COG0728 217 RDPGVRRVLKLMLPALLgVSVSQINL-LVDTILASFLPEGSVSALYYADRLYQLpLGLFGVAIGTALLPRLSRAAAAGDL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 85 FEVRRSFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTK----DPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKA 160
Cdd:COG0728 296 EEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVRLLFErgafTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDT 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 161 RLPLYASIAAALLNTALNYLLIfgkagfPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAeaagqteKGSRRRGSFRWK 240
Cdd:COG0728 376 RTPVRIAVIAVVVNIVLNLLLV------PPLGHAGLALATSLSALVNALLLLVLLRRRLGG-------LPLRGILRTLLK 442
|
250
....*....|....*...
gi 916666795 241 QYMAMLLPVLVCEFLWSL 258
Cdd:COG0728 443 LLLASLVMGAVLWLLLRL 460
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-183 |
4.45e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 54.99 E-value: 4.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 14 VCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLL 93
Cdd:cd13135 230 TIKLGLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNI 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 94 NLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALL 173
Cdd:cd13135 310 CLGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGTII 389
|
170
....*....|
gi 916666795 174 NTALNYLLIF 183
Cdd:cd13135 390 VVSVALLLIF 399
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-318 |
7.64e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 54.33 E-value: 7.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 9 PFFASVCRLAVPVALQSILQSSFSAVDQIMIGQLgDVS----VAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNR 84
Cdd:cd13146 5 PISPLLIRLALPILIGQLFQLLYNITDTIWISMI-DPSdpalVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 85 FEVRRSFLLNLFLSLGMAVLFSGLCLFFPERIMGLY-TKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLfRCMEKARLP 163
Cdd:cd13146 84 KELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLgAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVL-QGEGRTKYM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 164 LYASIAAALLNTALNYLLIFGKAgfppMGERGAAAATLLSQGMNFLLMLFMFfrlrgaeAAGQTEKGSRRRGS-FRWKQY 242
Cdd:cd13146 163 MMAMLIGTVVNIVLDPILIFVFD----MGVKGAALATVLAQAISLLYLLYVF-------LIGKSNVTIHIKLSnISSSVI 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 916666795 243 MAML---LPVLVCEFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAA 318
Cdd:cd13146 232 VEILrvgLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQI 310
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-315 |
1.69e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 53.43 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 9 PFFASVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVV-VSAVGTVAGIMISQYIGQKNRFEV 87
Cdd:cd13148 9 PILPTLLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMsNGAMGGGVSSAIARALGAGDRERA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 88 RRSFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYAS 167
Cdd:cd13148 89 EALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 168 IAAALLNTALNYLLIFGKAGFPPMGERGAAAATLLSQGMNFLLMLFMFFRLRGAeaagqtEKGSRRRGSFRWKQYMAML- 246
Cdd:cd13148 169 LVGAVVQIPLSPGLILGWGPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSR------LRLRLRALRLERRLFRDILr 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 916666795 247 --LPVLVCEFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGA 315
Cdd:cd13148 243 vgLLAALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARA 313
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
16-218 |
4.60e-07 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 52.09 E-value: 4.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMI-------GQLGDVSVAAVGI----AGKFASIFSVVVSAVGTVAGIMISQYIGQKNR 84
Cdd:COG5841 237 RIAIPITLSSLVLPLFQLIDSFTVprrlqaaGLSASEATSLYGIlsgmAQPLVNLPTVLATALATSLVPAISEAFAKKDR 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 85 FEVRRSFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPgvrrAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPL 164
Cdd:COG5841 317 KLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNP----EGGGILAILAPSAIFLSLQQVTTGILQGLGKQKIPV 392
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 916666795 165 YASIAAALLNTALNYLLIfgkagfPPMGERGAAAATLLSQGMNFLLMLFMFFRL 218
Cdd:COG5841 393 INLLIGLLVKIILNYLLV------PLFGIYGAALATVIGYLVAAILNLAALKKY 440
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
40-147 |
1.12e-06 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 50.64 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 40 GQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLNLFLSLGMAVLFSGLCLFFPERIMGL 119
Cdd:cd13136 253 ARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFFLGGEPIIRL 332
|
90 100
....*....|....*....|....*...
gi 916666795 120 YTKDPGVRRAAAGYLFIIggSFLPLAGA 147
Cdd:cd13136 333 FTDDPAVLALAATYLPWL--ALLPPIGA 358
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
16-126 |
2.28e-06 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 49.81 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLNL 95
Cdd:PRK01766 243 KLGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGL 322
|
90 100 110
....*....|....*....|....*....|.
gi 916666795 96 FLSLGMAVLFSGLCLFFPERIMGLYTKDPGV 126
Cdd:PRK01766 323 AVGLGMALLTAIFLVLFREQIALLYTDDPEV 353
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
16-138 |
4.09e-06 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 48.78 E-value: 4.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 16 RLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLNL 95
Cdd:TIGR00797 220 KLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVAL 299
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 916666795 96 FLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIG 138
Cdd:TIGR00797 300 KLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
10-204 |
2.32e-05 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 46.65 E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 10 FFASVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRR 89
Cdd:PRK10189 27 FWREITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 90 SFLLNLFLSLGMAVLFSGLCLFFPERIMGLYT--KDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYAS 167
Cdd:PRK10189 107 AARQSLVIMTLFAVLLAVLIHFFGEQIIDLVAgdATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPLLIN 186
|
170 180 190
....*....|....*....|....*....|....*..
gi 916666795 168 IAAALLNTALNYLLIFGKAGFPPMGERGAAAATLLSQ 204
Cdd:PRK10189 187 GGMNILNIIISSILIYGLFSWQGLGFVGAGLGLTISR 223
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
35-214 |
5.61e-05 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 45.51 E-value: 5.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 35 DQIMIGQLGDVSVAAVGIAG---KFASIFSV-VVSAVGTVAGIMIsqyiGQKNRFEVRRSFLLNLFLSLGMAvLFSGLCL 110
Cdd:PRK00187 33 DTLMMGRLGPEALAGGGLGAasySFVSIFCVgVIAAVGTLVAIRH----GAGDIEGATRLAQAGLWLAWLLA-LVAALLL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 111 FFPERIMGLYTKDPGVRRAAAGYLFIiggsfLPLAGATLLSVL-----FRCMEKARLPLYASIAAALLNTALNYLLIFGK 185
Cdd:PRK00187 108 WNLKPLLLLFGQAPQNVDAAMQFLHL-----LPFALPGYLSFMalrgfTSALGRAGPVMVISLAGAVANLLLNYALIEGW 182
|
170 180 190
....*....|....*....|....*....|
gi 916666795 186 AGFPPMGERGAAAAT-LLSQGMNFLLMLFM 214
Cdd:PRK00187 183 FGLPKLGLMGIGLVTaLVSNGMALALALYI 212
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-143 |
2.37e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 43.46 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 7 KHPFFASVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFE 86
Cdd:cd13141 231 DLPTWKRLLKIGLPSGGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDR 310
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 916666795 87 VRRSFLLNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLP 143
Cdd:cd13141 311 VRETFRITAILTTALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVA 367
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
133-214 |
2.37e-04 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 41.02 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 133 YLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLNTALNYLLIfgkagfPPMGERGAAAATLLSQGMNFLLML 212
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLI------PLFGIVGAAIATVISLLVVALLNL 74
|
..
gi 916666795 213 FM 214
Cdd:pfam14667 75 YY 76
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-154 |
4.66e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 42.21 E-value: 4.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 13 SVCRLAVPVALQSILQSSFSAVDQIMIGQLGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFL 92
Cdd:cd13139 240 KIIKIAVGGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVW 319
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 916666795 93 LNLFLSLGMAVLFSGLCLFFPERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLF 154
Cdd:cd13139 320 RAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAF 381
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
248-408 |
2.21e-03 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 38.70 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 248 PVLVCEFLWSLGENVYTAIYGHMRTEASAAMILTGPIQGLMIGALCGLSQAAGVIVGKRLGNKDYKGAYAASKRLLLYGL 327
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 328 SGSLLLSVLIILTSRLYAGIYQVGDSVKLLTAQILIAYALVAPFKVLNMILgGGIIRSGGRTKYVMFIDIIGTwIFGVPL 407
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVL-SGFLRGQGDTKPPMYINIISL-LLNIPL 158
|
.
gi 916666795 408 G 408
Cdd:pfam01554 159 N 159
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
34-216 |
6.18e-03 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 38.82 E-value: 6.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 34 VDQIMIGQ-LGDVSVAAVGIAGKFASIFSVVVSAVGTVAGIMISQYIGQKNRFEVRRSFLLNLFLSLGMAVLFSGLCLFF 112
Cdd:PRK09575 34 VDGIFIGHyVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGEGDLEKAKRILTTGLLLLLLLGPIVSVILFLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916666795 113 PERIMGLYTKDPGVRRAAAGYLFIIGGSFLPLAGATLLSVLFRCMEKARLPLYASIAAALLNTALNYLLIfgkaGFPPMG 192
Cdd:PRK09575 114 ADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGALINIVLDYLFI----GWLDWG 189
|
170 180
....*....|....*....|....
gi 916666795 193 ERGAAAATLLSQGMNFLLMLFMFF 216
Cdd:PRK09575 190 LTGAAIATALAQLVVTVLGLGYFF 213
|
|
| |
