|
Name |
Accession |
Description |
Interval |
E-value |
| ATS super family |
cl21266 |
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ... |
2357-2730 |
5.96e-170 |
|
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.
The actual alignment was detected with superfamily member pfam15445:
Pssm-ID: 373851 [Multi-domain] Cd Length: 446 Bit Score: 531.30 E-value: 5.96e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2357 AFPLSVGIAFAALSYFLLKKKTKSTI-DLLRVINIPKGDYGIPTMKSKNRYIPYASDRYKGKTYIYMEGDESDDYTYIGD 2435
Cdd:pfam15445 1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEKYAFM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2436 ISSSDITSSESEYEDIDINNIYPYKSPKYKTLIDVVLEPSKRDTSNRSsgtkDTQN-ITASDTPRNKPINDVEWNSLKND 2514
Cdd:pfam15445 81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTNTPS----DTQNdIPSDDIPSTNKITDEEWNTLKHD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2515 FISNISQNSQMDLPKNNISGNIQMDTHPHVNILDDsMQEKPFITSIHDRDLHNGEEVTYninlddhkNMNFSTNHDNIPP 2594
Cdd:pfam15445 157 FISNMLQNTQNDEPNILHSGNVPNNTHPNTLSRDN-MEEKPFIMSIHDRNLYTGEEYSY--------NINMSTNSMDDIP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2595 KNDQNDLYTGIDLINDSISGNHNVNIYDELLKRKENELFGTNHTKHTTTNIVAKQTHNDPIVNQINLFHKWLDRHRNMCE 2674
Cdd:pfam15445 228 KYVSNNVYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCE 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 914545537 2675 QWdkNKKEELLDKLNEEWNKENKNNSNVTDTNGENNITRVLNSDVSIQIDM-NSKPI 2730
Cdd:pfam15445 308 KW--KNKEERLDKLKEEWNKENNHSGDIHPSDDIPSDNKVLNTDVSIQIDMdNPKPK 362
|
|
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1621-2730 |
1.46e-111 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 389.78 E-value: 1.46e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1621 EQKFKNRKKSYPGWD-CRPNtfKTDHDDGACMPPRRQKLYIHKLKELSDQKSET--DLRQAFIECAAIETffawhkykee 1697
Cdd:PTZ00176 94 QNRFDENGESYCNSDkIRGN--ENNSNAGACAPFRRQNMCDKNLEYLINKNTENthDLLGNVLVTAKYEG---------- 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1698 kkkkekeqqylvaytSSVEENLKNElESGQIPEDFKRqmfyTYADYRDIFFGKDIGR--DIDTLNHKIDTIFPK------ 1769
Cdd:PTZ00176 162 ---------------ESIVNNHPDK-DKSSVCTALAR----SFADIGDIVRGKDMFKrnKHDNVENGLREVFKKiyeglk 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1770 -NGA--HNSDEK-------REQWWQANGPHIWDGMLCAL---SYDTETRImDQNARKNLNDPRnnndyktvkftSKSGPS 1836
Cdd:PTZ00176 222 nNGAreHYKEVKngnyiklREDWWTANRDQVWKAMTCVApenAYFRKTEA-DGIGISSLILPY-----------SKCGRD 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1837 VDVKLDDFAkrSQYFRWLEEWGDEFCKKRKDKLENIEKECRGERGQNYCDGDGfdctnirpneegifEDFNCRSCAKSCN 1916
Cdd:PTZ00176 290 TDPPVVDYI--PQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDT--------------EGEKCKKCKEQCQ 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1917 SYKQWINKKKDEFHKQKEKYQKEIDNAKSN--------SRNAYDQNFVGKLHNDYKTIESFLEKL----------KGPFS 1978
Cdd:PTZ00176 354 IFKELVSKWKNQFDKQSMKYMELYNKASTNitkqnssaPERGYRRNHRRRGYDDDTNVQLFLKKVienneckvesLGKYL 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1979 DNNTGCSTIDFKNIN--------------KTFGHAEYCA------PCP----------------VFGVNCKGDYC----- 2017
Cdd:PTZ00176 434 DKTSHCGNYNFNYDNtpgsnrsnafeitpEKFKKACKCKipnpleKCPneenknvctrfdkvysCTSLSFKNDLSewnns 513
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2018 -IGAKEKDCNGKTFIGAEDIGKMEKYIKVDMLVTDNtvNKFPDDLKDACIDTGIFEGIRGNKWS--------CGYLCGFD 2088
Cdd:PTZ00176 514 gVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMKDE--NDFKEDLLNAAFSQGKLLGKKYSNYSneayeamkFSYADYSD 591
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2089 VCK----MNNF---------------------DEKK--DDKQNILFRTL----------------------------FKR 2113
Cdd:PTZ00176 592 IVKgtdmMNDLkklnkelntllketekgdisvDRKTwwDDNKNVVWNAMlcgyktenenqqlnsswcnvpdddnidqFLR 671
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2114 WLEYFLKDY------------NKIKDSLNPCMHNGKRNVCINGCKEKCNCVDKWIDNKSKEWGKVRERYFKQYKIDNSEI 2181
Cdd:PTZ00176 672 WLTEWAQQYckeklikahiinTKCKDIVEGRKHKSMVDITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKKSKNSGV 751
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2182 yydvrrflEMMQPESEVKKVKS-------NFKDLEaletasgciytDLSKNSKEKdvvecllNKLKKE-INNCKNQSDdg 2253
Cdd:PTZ00176 752 --------NIPSEECAASYVTKhcngcicNLRDME-----------DIHKNINNQ-------NELMKEmINIIKFDTD-- 803
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2254 tdsNCSTPLPTDTYTPESSPHEFFTPeeeeVDMApkfcpKDIPEPEPDDDLLPGPVPEQKED---EKFPAKVPEVpKKPV 2330
Cdd:PTZ00176 804 ---QYRTQLQNISNSMEINPKSVKTA----VDTT-----KDIVSYGLAGTMGVAAIGLQAGDflgKKIQDLYNEF-MKPV 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2331 pEKKVTPRRRPREITRSilPEMVsisaFPLSVGIAFA-ALSYFLLKKKTKSTIDLLRVINIPKGDYGIPTMKSKNRYIPY 2409
Cdd:PTZ00176 871 -EKKLDTSSKNLNIYED--PNIM----VPAGIGVALTlGLLLFKMRRKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPY 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2410 ASDRYKGKTYIYMEGDeSDDYTYIGDISSSDITSSESEYEDIDINNIYPYKSPKYKTLIDVVLEPSKRDTSNrssgtkdt 2489
Cdd:PTZ00176 944 GSQRYKGKTYLYVEGD-TDEEKYMFMSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKRDTQN-------- 1014
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2490 qNITASDTPRNKpINDVEWNSLKNDFISNISQNSQmdlPKNNI-SGNIQMDTHPHVNILDDsMQEKPFITSIHDRDLHNG 2568
Cdd:PTZ00176 1015 -DIPSDNTPSYK-LTDEEWNQLKDDFISQYLPNTE---PNNNYrSGNSPTNTNNTTTSHDN-MGEKPFIMSIHDRNLYTG 1088
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2569 EEVTYNInlddhkNMNFSTNHDnipPKNDQNDLYTGIDLINDSISGNHNVNIYDELLKRKENELFGTNHTKHTTTNIVAK 2648
Cdd:PTZ00176 1089 EEISYNI------NMSTNTMDD---PKYVSNNVYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAK 1159
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2649 QTHN-DPIVNQINLFHKWLDRHRNMCEQWdkNKKEELLDKLNEEWNKENkNNSNVTDTNgennitRVLNSDVSIQIDM-N 2726
Cdd:PTZ00176 1160 NTYSdDAITNKINLFHKWLDRHRDMCEKW--ENHHERLAKLKEKWENDN-DGGNVPSDN------HVLNTDVSIEIDMdN 1230
|
....
gi 914545537 2727 SKPI 2730
Cdd:PTZ00176 1231 PKPI 1234
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
106-292 |
8.62e-75 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
:
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 246.80 E-value: 8.62e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 106 ACAPLRRLHLCDRNLEEIKYNKINQTDNLLVDVLLAAKYEGESIRNAYSQ---KSNDYKSGLCTALARSFADIGDIIRGK 182
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKkntKYGDIPSEFCRQMAYSFADIGDIIRGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 183 DLFLGgpDQEKKKLEENLRNIFKNIHDHLTDakaksyyKNDNDRNYFKLRNDWWELNRQQVWNAITCGAPSDAQYFRNTC 262
Cdd:pfam05424 81 DLYLG--NNKKKKLEENLKKIFKKIYEKLTS-------KGKDDGNYYQLREDWWEANREDIWKAMTCALTYGAKYFRKTC 151
|
170 180 190
....*....|....*....|....*....|
gi 914545537 263 SSIKGGHYKNCHCiggDVLTNFDYVPQYLR 292
Cdd:pfam05424 152 GDGISPSTAGCND---DVPTYFDYVPQFLR 178
|
|
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
11-458 |
1.00e-72 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 269.60 E-value: 1.00e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 11 AKEILDKLGEQIQKEVHTKAlEYENDLHGFLSRVEFKKGENNKI-------TNPCDLNHEYQTTVTTGH---SYPCENRL 80
Cdd:PTZ00176 15 ARNVLENIGNEIKDKRENES-KYTDKLKGSLWEARFSDGLSSSFgdvrsgyYDSCSLDHKFHTNINNGYppaRNPCDGRN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 81 NVRFSDVISGQCTNKKIKGNEG--KEGACAPLRRLHLCDRNLEEIKYNKINQTDNLLVDVLLAAKYEGESIRNAYSQKSn 158
Cdd:PTZ00176 94 QNRFDENGESYCNSDKIRGNENnsNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDKD- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 159 dyKSGLCTALARSFADIGDIIRGKDLFlggPDQEKKKLEENLRNIFKNIHDHLTDAKAKSYYKNDNDRNYFKLRNDWWEL 238
Cdd:PTZ00176 173 --KSSVCTALARSFADIGDIVRGKDMF---KRNKHDNVENGLREVFKKIYEGLKNNGAREHYKEVKNGNYIKLREDWWTA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 239 NRQQVWNAITCGAPSDAqYFRNT------CSSIKGGHYKNCHCIGGDVLtnfDYVPQYLRWFDEWTEEFCRKKKKYVDIV 312
Cdd:PTZ00176 248 NRDQVWKAMTCVAPENA-YFRKTeadgigISSLILPYSKCGRDTDPPVV---DYIPQRLRWMSEWSEYFCNVLNKEIDEM 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 313 KKYCRDESEGKYCslngHDCTEtirkigllrmGNGCTNCLHACTHYRGWLAKQQEEFEKQKKKYTKEIN--GSNPPKNDI 390
Cdd:PTZ00176 324 NNQCKDCEMSRRC----NNDTE----------GEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNkaSTNITKQNS 389
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 914545537 391 SNTA---NNEHDRKFYgklkTEYGNVHTFLKLLNEEKECKVITTGE--------GQINFPINDYKETfYRSEYCEMCPE 458
Cdd:PTZ00176 390 SAPErgyRRNHRRRGY----DDDTNVQLFLKKVIENNECKVESLGKyldktshcGNYNFNYDNTPGS-NRSNAFEITPE 463
|
|
| PTZ00176 super family |
cl31413 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
752-1543 |
3.79e-65 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
The actual alignment was detected with superfamily member PTZ00176:
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 245.33 E-value: 3.79e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 752 RSIVNRVAHHFREVAHNKMKENiksNSVKGSkhnVLEADATKGIYKSSGN-SVPLTDICTINEN-HSNRNP--KNSSGPC 827
Cdd:PTZ00176 16 RNVLENIGNEIKDKRENESKYT---DKLKGS---LWEARFSDGLSSSFGDvRSGYYDSCSLDHKfHTNINNgyPPARNPC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 828 QGKDQGRF------KIGKDWTNVNEKQKTTykDVIMPQRREHMCTSNLEYLETKCrpldgkgddcDKVNHSFLGDVLLSA 901
Cdd:PTZ00176 90 DGRNQNRFdengesYCNSDKIRGNENNSNA--GACAPFRRQNMCDKNLEYLINKN----------TENTHDLLGNVLVTA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 902 KKEGDFIVEKL-RSDKSAICNAMKYSFADIGDIIRGRDMWDLNDgSQKMETILKNIFGTLHRSLDGIKGNDKYTQDENKT 980
Cdd:PTZ00176 158 KYEGESIVNNHpDKDKSSVCTALARSFADIGDIVRGKDMFKRNK-HDNVENGLREVFKKIYEGLKNNGAREHYKEVKNGN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 981 pkYKQLREDWWEANRKQIWHAMQCALKSGNEI------------------QCNNHT--PIEDYIPQRLRWMNEWAEWYCK 1040
Cdd:PTZ00176 237 --YIKLREDWWTANRDQVWKAMTCVAPENAYFrkteadgigisslilpysKCGRDTdpPVVDYIPQRLRWMSEWSEYFCN 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1041 EQSMLYNKLVADCGDCmkkgEGGKECMNGS--GECRKCKQACEEYKAKIKKWQEQWDKMQLKYLYFYHEAKTT------- 1111
Cdd:PTZ00176 315 VLNKEIDEMNNQCKDC----EMSRRCNNDTegEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNitkqnss 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1112 ----------SRHGIDaysgavepKDKPVVKFLQELLPPNSDKsgvppstptpYSTAAGYIHQelpNVGCMKQEVFCDNN 1181
Cdd:PTZ00176 391 apergyrrnhRRRGYD--------DDTNVQLFLKKVIENNECK----------VESLGKYLDK---TSHCGNYNFNYDNT 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1182 -GNKGKYVFMDPPKGYEDACGCdkNVLKPPEK--KEEIKKACEIVE------TLIAKNNDGNTAIGGCNPKHQGgsypvw 1252
Cdd:PTZ00176 450 pGSNRSNAFEITPEKFKKACKC--KIPNPLEKcpNEENKNVCTRFDkvysctSLSFKNDLSEWNNSGVKNKEND------ 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1253 dcTNPILVtgkgecmPPRRIKLC--LYYLKELSDTTQKGLREAFIKTAASETFFAWHYYNSKNANAQEQLKagkippdfl 1330
Cdd:PTZ00176 522 --NNGVLV-------PPRRRNLCinLFSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSNEAYEAMK--------- 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1331 rsmfYTFGDYRDICLDTDISakhanGDVTKAKEKIDEIFPKGKTND--TEPKEFWNKYAQNIWEAMLCALEKAgddkvkf 1408
Cdd:PTZ00176 584 ----FSYADYSDIVKGTDMM-----NDLKKLNKELNTLLKETEKGDisVDRKTWWDDNKNVVWNAMLCGYKTE------- 647
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1409 TDNPAYNYETVTFSGDNSHTleefttrpQFLRWMTEWGEHFCREHKVEKGKLVKQCDSCGLDGTGKT-CDGECGACKDQC 1487
Cdd:PTZ00176 648 NENQQLNSSWCNVPDDDNID--------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVEGRKHKSmVDITDVECKRLF 719
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*...
gi 914545537 1488 KKYQDWLQKWQDNYKKQKQRYTQVKGTspynKDDDVTISTH--AYEYLNKKLTNISCN 1543
Cdd:PTZ00176 720 IDYEEWFRYRYNQWKGLSEKYIKIKKS----KNSGVNIPSEecAASYVTKHCNGCICN 773
|
|
| PFEMP super family |
cl03834 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
562-705 |
4.06e-32 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
The actual alignment was detected with superfamily member pfam03011:
Pssm-ID: 281064 Cd Length: 154 Bit Score: 123.76 E-value: 4.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 562 FFELWVTHLLQDSIEWRKEISKCLNNNSLTKCSNRCNRYCRFFKKWVEQKKKEWTQIKNHFEKQEGLPKNQHFTILETLL 641
Cdd:pfam03011 1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLDEYLD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 914545537 642 ------EEEFFDQIKEAYGDVKSIEKIKVLLSKRRIKKDDELQ---NKEDIIEKLLEHELEDYEKCKETHNDD 705
Cdd:pfam03011 81 lksfleTFLFYIDIKEAYGDVKELKKLEEILDEEGCSAGAESAknnKNEDAIDKLLDKEEKKANNCKEKHKEN 153
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ATS |
pfam15445 |
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ... |
2357-2730 |
5.96e-170 |
|
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.
Pssm-ID: 373851 [Multi-domain] Cd Length: 446 Bit Score: 531.30 E-value: 5.96e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2357 AFPLSVGIAFAALSYFLLKKKTKSTI-DLLRVINIPKGDYGIPTMKSKNRYIPYASDRYKGKTYIYMEGDESDDYTYIGD 2435
Cdd:pfam15445 1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEKYAFM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2436 ISSSDITSSESEYEDIDINNIYPYKSPKYKTLIDVVLEPSKRDTSNRSsgtkDTQN-ITASDTPRNKPINDVEWNSLKND 2514
Cdd:pfam15445 81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTNTPS----DTQNdIPSDDIPSTNKITDEEWNTLKHD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2515 FISNISQNSQMDLPKNNISGNIQMDTHPHVNILDDsMQEKPFITSIHDRDLHNGEEVTYninlddhkNMNFSTNHDNIPP 2594
Cdd:pfam15445 157 FISNMLQNTQNDEPNILHSGNVPNNTHPNTLSRDN-MEEKPFIMSIHDRNLYTGEEYSY--------NINMSTNSMDDIP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2595 KNDQNDLYTGIDLINDSISGNHNVNIYDELLKRKENELFGTNHTKHTTTNIVAKQTHNDPIVNQINLFHKWLDRHRNMCE 2674
Cdd:pfam15445 228 KYVSNNVYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCE 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 914545537 2675 QWdkNKKEELLDKLNEEWNKENKNNSNVTDTNGENNITRVLNSDVSIQIDM-NSKPI 2730
Cdd:pfam15445 308 KW--KNKEERLDKLKEEWNKENNHSGDIHPSDDIPSDNKVLNTDVSIQIDMdNPKPK 362
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1621-2730 |
1.46e-111 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 389.78 E-value: 1.46e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1621 EQKFKNRKKSYPGWD-CRPNtfKTDHDDGACMPPRRQKLYIHKLKELSDQKSET--DLRQAFIECAAIETffawhkykee 1697
Cdd:PTZ00176 94 QNRFDENGESYCNSDkIRGN--ENNSNAGACAPFRRQNMCDKNLEYLINKNTENthDLLGNVLVTAKYEG---------- 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1698 kkkkekeqqylvaytSSVEENLKNElESGQIPEDFKRqmfyTYADYRDIFFGKDIGR--DIDTLNHKIDTIFPK------ 1769
Cdd:PTZ00176 162 ---------------ESIVNNHPDK-DKSSVCTALAR----SFADIGDIVRGKDMFKrnKHDNVENGLREVFKKiyeglk 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1770 -NGA--HNSDEK-------REQWWQANGPHIWDGMLCAL---SYDTETRImDQNARKNLNDPRnnndyktvkftSKSGPS 1836
Cdd:PTZ00176 222 nNGAreHYKEVKngnyiklREDWWTANRDQVWKAMTCVApenAYFRKTEA-DGIGISSLILPY-----------SKCGRD 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1837 VDVKLDDFAkrSQYFRWLEEWGDEFCKKRKDKLENIEKECRGERGQNYCDGDGfdctnirpneegifEDFNCRSCAKSCN 1916
Cdd:PTZ00176 290 TDPPVVDYI--PQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDT--------------EGEKCKKCKEQCQ 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1917 SYKQWINKKKDEFHKQKEKYQKEIDNAKSN--------SRNAYDQNFVGKLHNDYKTIESFLEKL----------KGPFS 1978
Cdd:PTZ00176 354 IFKELVSKWKNQFDKQSMKYMELYNKASTNitkqnssaPERGYRRNHRRRGYDDDTNVQLFLKKVienneckvesLGKYL 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1979 DNNTGCSTIDFKNIN--------------KTFGHAEYCA------PCP----------------VFGVNCKGDYC----- 2017
Cdd:PTZ00176 434 DKTSHCGNYNFNYDNtpgsnrsnafeitpEKFKKACKCKipnpleKCPneenknvctrfdkvysCTSLSFKNDLSewnns 513
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2018 -IGAKEKDCNGKTFIGAEDIGKMEKYIKVDMLVTDNtvNKFPDDLKDACIDTGIFEGIRGNKWS--------CGYLCGFD 2088
Cdd:PTZ00176 514 gVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMKDE--NDFKEDLLNAAFSQGKLLGKKYSNYSneayeamkFSYADYSD 591
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2089 VCK----MNNF---------------------DEKK--DDKQNILFRTL----------------------------FKR 2113
Cdd:PTZ00176 592 IVKgtdmMNDLkklnkelntllketekgdisvDRKTwwDDNKNVVWNAMlcgyktenenqqlnsswcnvpdddnidqFLR 671
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2114 WLEYFLKDY------------NKIKDSLNPCMHNGKRNVCINGCKEKCNCVDKWIDNKSKEWGKVRERYFKQYKIDNSEI 2181
Cdd:PTZ00176 672 WLTEWAQQYckeklikahiinTKCKDIVEGRKHKSMVDITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKKSKNSGV 751
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2182 yydvrrflEMMQPESEVKKVKS-------NFKDLEaletasgciytDLSKNSKEKdvvecllNKLKKE-INNCKNQSDdg 2253
Cdd:PTZ00176 752 --------NIPSEECAASYVTKhcngcicNLRDME-----------DIHKNINNQ-------NELMKEmINIIKFDTD-- 803
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2254 tdsNCSTPLPTDTYTPESSPHEFFTPeeeeVDMApkfcpKDIPEPEPDDDLLPGPVPEQKED---EKFPAKVPEVpKKPV 2330
Cdd:PTZ00176 804 ---QYRTQLQNISNSMEINPKSVKTA----VDTT-----KDIVSYGLAGTMGVAAIGLQAGDflgKKIQDLYNEF-MKPV 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2331 pEKKVTPRRRPREITRSilPEMVsisaFPLSVGIAFA-ALSYFLLKKKTKSTIDLLRVINIPKGDYGIPTMKSKNRYIPY 2409
Cdd:PTZ00176 871 -EKKLDTSSKNLNIYED--PNIM----VPAGIGVALTlGLLLFKMRRKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPY 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2410 ASDRYKGKTYIYMEGDeSDDYTYIGDISSSDITSSESEYEDIDINNIYPYKSPKYKTLIDVVLEPSKRDTSNrssgtkdt 2489
Cdd:PTZ00176 944 GSQRYKGKTYLYVEGD-TDEEKYMFMSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKRDTQN-------- 1014
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2490 qNITASDTPRNKpINDVEWNSLKNDFISNISQNSQmdlPKNNI-SGNIQMDTHPHVNILDDsMQEKPFITSIHDRDLHNG 2568
Cdd:PTZ00176 1015 -DIPSDNTPSYK-LTDEEWNQLKDDFISQYLPNTE---PNNNYrSGNSPTNTNNTTTSHDN-MGEKPFIMSIHDRNLYTG 1088
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2569 EEVTYNInlddhkNMNFSTNHDnipPKNDQNDLYTGIDLINDSISGNHNVNIYDELLKRKENELFGTNHTKHTTTNIVAK 2648
Cdd:PTZ00176 1089 EEISYNI------NMSTNTMDD---PKYVSNNVYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAK 1159
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2649 QTHN-DPIVNQINLFHKWLDRHRNMCEQWdkNKKEELLDKLNEEWNKENkNNSNVTDTNgennitRVLNSDVSIQIDM-N 2726
Cdd:PTZ00176 1160 NTYSdDAITNKINLFHKWLDRHRDMCEKW--ENHHERLAKLKEKWENDN-DGGNVPSDN------HVLNTDVSIEIDMdN 1230
|
....
gi 914545537 2727 SKPI 2730
Cdd:PTZ00176 1231 PKPI 1234
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
106-292 |
8.62e-75 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 246.80 E-value: 8.62e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 106 ACAPLRRLHLCDRNLEEIKYNKINQTDNLLVDVLLAAKYEGESIRNAYSQ---KSNDYKSGLCTALARSFADIGDIIRGK 182
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKkntKYGDIPSEFCRQMAYSFADIGDIIRGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 183 DLFLGgpDQEKKKLEENLRNIFKNIHDHLTDakaksyyKNDNDRNYFKLRNDWWELNRQQVWNAITCGAPSDAQYFRNTC 262
Cdd:pfam05424 81 DLYLG--NNKKKKLEENLKKIFKKIYEKLTS-------KGKDDGNYYQLREDWWEANREDIWKAMTCALTYGAKYFRKTC 151
|
170 180 190
....*....|....*....|....*....|
gi 914545537 263 SSIKGGHYKNCHCiggDVLTNFDYVPQYLR 292
Cdd:pfam05424 152 GDGISPSTAGCND---DVPTYFDYVPQFLR 178
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
11-458 |
1.00e-72 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 269.60 E-value: 1.00e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 11 AKEILDKLGEQIQKEVHTKAlEYENDLHGFLSRVEFKKGENNKI-------TNPCDLNHEYQTTVTTGH---SYPCENRL 80
Cdd:PTZ00176 15 ARNVLENIGNEIKDKRENES-KYTDKLKGSLWEARFSDGLSSSFgdvrsgyYDSCSLDHKFHTNINNGYppaRNPCDGRN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 81 NVRFSDVISGQCTNKKIKGNEG--KEGACAPLRRLHLCDRNLEEIKYNKINQTDNLLVDVLLAAKYEGESIRNAYSQKSn 158
Cdd:PTZ00176 94 QNRFDENGESYCNSDKIRGNENnsNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDKD- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 159 dyKSGLCTALARSFADIGDIIRGKDLFlggPDQEKKKLEENLRNIFKNIHDHLTDAKAKSYYKNDNDRNYFKLRNDWWEL 238
Cdd:PTZ00176 173 --KSSVCTALARSFADIGDIVRGKDMF---KRNKHDNVENGLREVFKKIYEGLKNNGAREHYKEVKNGNYIKLREDWWTA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 239 NRQQVWNAITCGAPSDAqYFRNT------CSSIKGGHYKNCHCIGGDVLtnfDYVPQYLRWFDEWTEEFCRKKKKYVDIV 312
Cdd:PTZ00176 248 NRDQVWKAMTCVAPENA-YFRKTeadgigISSLILPYSKCGRDTDPPVV---DYIPQRLRWMSEWSEYFCNVLNKEIDEM 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 313 KKYCRDESEGKYCslngHDCTEtirkigllrmGNGCTNCLHACTHYRGWLAKQQEEFEKQKKKYTKEIN--GSNPPKNDI 390
Cdd:PTZ00176 324 NNQCKDCEMSRRC----NNDTE----------GEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNkaSTNITKQNS 389
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 914545537 391 SNTA---NNEHDRKFYgklkTEYGNVHTFLKLLNEEKECKVITTGE--------GQINFPINDYKETfYRSEYCEMCPE 458
Cdd:PTZ00176 390 SAPErgyRRNHRRRGY----DDDTNVQLFLKKVIENNECKVESLGKyldktshcGNYNFNYDNTPGS-NRSNAFEITPE 463
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
752-1543 |
3.79e-65 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 245.33 E-value: 3.79e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 752 RSIVNRVAHHFREVAHNKMKENiksNSVKGSkhnVLEADATKGIYKSSGN-SVPLTDICTINEN-HSNRNP--KNSSGPC 827
Cdd:PTZ00176 16 RNVLENIGNEIKDKRENESKYT---DKLKGS---LWEARFSDGLSSSFGDvRSGYYDSCSLDHKfHTNINNgyPPARNPC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 828 QGKDQGRF------KIGKDWTNVNEKQKTTykDVIMPQRREHMCTSNLEYLETKCrpldgkgddcDKVNHSFLGDVLLSA 901
Cdd:PTZ00176 90 DGRNQNRFdengesYCNSDKIRGNENNSNA--GACAPFRRQNMCDKNLEYLINKN----------TENTHDLLGNVLVTA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 902 KKEGDFIVEKL-RSDKSAICNAMKYSFADIGDIIRGRDMWDLNDgSQKMETILKNIFGTLHRSLDGIKGNDKYTQDENKT 980
Cdd:PTZ00176 158 KYEGESIVNNHpDKDKSSVCTALARSFADIGDIVRGKDMFKRNK-HDNVENGLREVFKKIYEGLKNNGAREHYKEVKNGN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 981 pkYKQLREDWWEANRKQIWHAMQCALKSGNEI------------------QCNNHT--PIEDYIPQRLRWMNEWAEWYCK 1040
Cdd:PTZ00176 237 --YIKLREDWWTANRDQVWKAMTCVAPENAYFrkteadgigisslilpysKCGRDTdpPVVDYIPQRLRWMSEWSEYFCN 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1041 EQSMLYNKLVADCGDCmkkgEGGKECMNGS--GECRKCKQACEEYKAKIKKWQEQWDKMQLKYLYFYHEAKTT------- 1111
Cdd:PTZ00176 315 VLNKEIDEMNNQCKDC----EMSRRCNNDTegEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNitkqnss 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1112 ----------SRHGIDaysgavepKDKPVVKFLQELLPPNSDKsgvppstptpYSTAAGYIHQelpNVGCMKQEVFCDNN 1181
Cdd:PTZ00176 391 apergyrrnhRRRGYD--------DDTNVQLFLKKVIENNECK----------VESLGKYLDK---TSHCGNYNFNYDNT 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1182 -GNKGKYVFMDPPKGYEDACGCdkNVLKPPEK--KEEIKKACEIVE------TLIAKNNDGNTAIGGCNPKHQGgsypvw 1252
Cdd:PTZ00176 450 pGSNRSNAFEITPEKFKKACKC--KIPNPLEKcpNEENKNVCTRFDkvysctSLSFKNDLSEWNNSGVKNKEND------ 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1253 dcTNPILVtgkgecmPPRRIKLC--LYYLKELSDTTQKGLREAFIKTAASETFFAWHYYNSKNANAQEQLKagkippdfl 1330
Cdd:PTZ00176 522 --NNGVLV-------PPRRRNLCinLFSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSNEAYEAMK--------- 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1331 rsmfYTFGDYRDICLDTDISakhanGDVTKAKEKIDEIFPKGKTND--TEPKEFWNKYAQNIWEAMLCALEKAgddkvkf 1408
Cdd:PTZ00176 584 ----FSYADYSDIVKGTDMM-----NDLKKLNKELNTLLKETEKGDisVDRKTWWDDNKNVVWNAMLCGYKTE------- 647
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1409 TDNPAYNYETVTFSGDNSHTleefttrpQFLRWMTEWGEHFCREHKVEKGKLVKQCDSCGLDGTGKT-CDGECGACKDQC 1487
Cdd:PTZ00176 648 NENQQLNSSWCNVPDDDNID--------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVEGRKHKSmVDITDVECKRLF 719
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*...
gi 914545537 1488 KKYQDWLQKWQDNYKKQKQRYTQVKGTspynKDDDVTISTH--AYEYLNKKLTNISCN 1543
Cdd:PTZ00176 720 IDYEEWFRYRYNQWKGLSEKYIKIKKS----KNSGVNIPSEecAASYVTKHCNGCICN 773
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
857-1029 |
2.18e-47 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 168.22 E-value: 2.18e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 857 MPQRREHMCTSNLEYLETKCrpldgkgddcDKVNHSFLGDVLLSAKKEGDFIVEKLRSDK-------SAICNAMKYSFAD 929
Cdd:pfam05424 3 APPRRLHLCVKNLEKINSGN----------TTTTHDLLKAVILAAKYEGFSLWHKYKKKNtkygdipSEFCRQMAYSFAD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 930 IGDIIRGRDMWDLNDGSQKMETILKNIFGtlhrsldgiKGNDKYTQDENKTPKYKQLREDWWEANRKQIWHAMQCALKSG 1009
Cdd:pfam05424 73 IGDIIRGKDLYLGNNKKKKLEENLKKIFK---------KIYEKLTSKGKDDGNYYQLREDWWEANREDIWKAMTCALTYG 143
|
170 180 190
....*....|....*....|....*....|....*
gi 914545537 1010 NEI---------------QCNNHTPIEDYIPQRLR 1029
Cdd:pfam05424 144 AKYfrktcgdgispstagCNDDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1649-1803 |
2.79e-41 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 150.89 E-value: 2.79e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1649 ACMPPRRQKLYIHKLKELSDQKSET--DLRQAFIECAAIETFFAWHKykeekkkkekeqqylvaYTssvEENLKNelesG 1726
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGNTTTthDLLKAVILAAKYEGFSLWHK-----------------YK---KKNTKY----G 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1727 QIPEDFKRQMFYTYADYRDIFFGKDIGR---DIDTLNHKIDTIFPKNG---------AHNSDEKREQWWQANGPHIWDGM 1794
Cdd:pfam05424 57 DIPSEFCRQMAYSFADIGDIIRGKDLYLgnnKKKKLEENLKKIFKKIYekltskgkdDGNYYQLREDWWEANREDIWKAM 136
|
....*....
gi 914545537 1795 LCALSYDTE 1803
Cdd:pfam05424 137 TCALTYGAK 145
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
562-705 |
4.06e-32 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 123.76 E-value: 4.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 562 FFELWVTHLLQDSIEWRKEISKCLNNNSLTKCSNRCNRYCRFFKKWVEQKKKEWTQIKNHFEKQEGLPKNQHFTILETLL 641
Cdd:pfam03011 1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLDEYLD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 914545537 642 ------EEEFFDQIKEAYGDVKSIEKIKVLLSKRRIKKDDELQ---NKEDIIEKLLEHELEDYEKCKETHNDD 705
Cdd:pfam03011 81 lksfleTFLFYIDIKEAYGDVKELKKLEEILDEEGCSAGAESAknnKNEDAIDKLLDKEEKKANNCKEKHKEN 153
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1264-1949 |
1.72e-29 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 129.38 E-value: 1.72e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1264 GECMPPRRIKLC---LYYLKELSDTTQKGLREAFIKTAASETFFAWHYYNSKNANaqeqlkagkippDFLRSMFYTFGDY 1340
Cdd:PTZ00176 120 GACAPFRRQNMCdknLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDKDKS------------SVCTALARSFADI 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1341 RDICLDTDISAKHANGDVTKA-KEKIDEIFPKGKTNDTEP--------------KEFWNKYAQNIWEAMLCALEKAGDDK 1405
Cdd:PTZ00176 188 GDIVRGKDMFKRNKHDNVENGlREVFKKIYEGLKNNGAREhykevkngnyiklrEDWWTANRDQVWKAMTCVAPENAYFR 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1406 VKFTDNPAYNYETVTFSG---DNSHTLEEFTtrPQFLRWMTEWGEHFCREHKVEKGKLVKQCDSCGLDG--TGKTCDGEC 1480
Cdd:PTZ00176 268 KTEADGIGISSLILPYSKcgrDTDPPVVDYI--PQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRrcNNDTEGEKC 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1481 GACKDQCKKYQDWLQKWQDNYKKQKQRY-----------TQVKGTSP---YNK-------DDDvtisTHAYEYLNKKLTN 1539
Cdd:PTZ00176 346 KKCKEQCQIFKELVSKWKNQFDKQSMKYmelynkastniTKQNSSAPergYRRnhrrrgyDDD----TNVQLFLKKVIEN 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1540 ISCNSGISGKCDYK---CMDQRSSTDGIPAS-----LEYPPIEYKEKCTCtdKPPEPPPPYPASVLPNACEIAEEILKAE 1611
Cdd:PTZ00176 422 NECKVESLGKYLDKtshCGNYNFNYDNTPGSnrsnaFEITPEKFKKACKC--KIPNPLEKCPNEENKNVCTRFDKVYSCT 499
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1612 SDNKYSDLCEqkfknrkksypgWDCRPNTFKTDHDDGACMPPRRQKLYIHKL-KELSDQKSETDLRQAFIECAaietffa 1690
Cdd:PTZ00176 500 SLSFKNDLSE------------WNNSGVKNKENDNNGVLVPPRRRNLCINLFsKKDYKMKDENDFKEDLLNAA------- 560
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1691 whkykeekkkkeKEQQYLVAYTSSveeNLKNELESGqipedfkrqMFYTYADYRDIFFGKDIGRDIDTLNHKIDTIFPKN 1770
Cdd:PTZ00176 561 ------------FSQGKLLGKKYS---NYSNEAYEA---------MKFSYADYSDIVKGTDMMNDLKKLNKELNTLLKET 616
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1771 GAHNSDEKREQWWQANGPHIWDGMLCAlsYDTEtrimdqNARKNLNDPRNNndyktvkftsksgpsvdVKLDDFAkrSQY 1850
Cdd:PTZ00176 617 EKGDISVDRKTWWDDNKNVVWNAMLCG--YKTE------NENQQLNSSWCN-----------------VPDDDNI--DQF 669
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1851 FRWLEEWGDEFCKKRKDKLENIEKECRgergqnycdgdgfDCTNIRPNEEGIfeDFNCRSCAKSCNSYKQWINKKKDEFH 1930
Cdd:PTZ00176 670 LRWLTEWAQQYCKEKLIKAHIINTKCK-------------DIVEGRKHKSMV--DITDVECKRLFIDYEEWFRYRYNQWK 734
|
730
....*....|....*....
gi 914545537 1931 KQKEKYQKeIDNAKSNSRN 1949
Cdd:PTZ00176 735 GLSEKYIK-IKKSKNSGVN 752
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
45-323 |
7.06e-15 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 81.62 E-value: 7.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 45 EFKKGENNKITNPCDL--NHEYQTTVTT-GHSYPCENrlnVRFSDVISgQCTNKKIKGNEG-KEGACAPLRRLHLCdRNL 120
Cdd:PTZ00176 464 KFKKACKCKIPNPLEKcpNEENKNVCTRfDKVYSCTS---LSFKNDLS-EWNNSGVKNKENdNNGVLVPPRRRNLC-INL 538
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 121 EEIKYNKINQTDNLLVDVLLAAKYEGESIRNAYSQKSNDYKSglctALARSFADIGDIIRGKDLFlggpdQEKKKLEENL 200
Cdd:PTZ00176 539 FSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSNEAYE----AMKFSYADYSDIVKGTDMM-----NDLKKLNKEL 609
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 201 RNIFKNIHdhltdakaksyyKNDNDRNyfklRNDWWELNRQQVWNAITCGAPSDAQYFRNTCSSikgghyknCHciggdv 280
Cdd:PTZ00176 610 NTLLKETE------------KGDISVD----RKTWWDDNKNVVWNAMLCGYKTENENQQLNSSW--------CN------ 659
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 914545537 281 LTNFDYVPQYLRWFDEWTEEFCRKKKKYVDIVKKYCRDESEGK 323
Cdd:PTZ00176 660 VPDDDNIDQFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVEGR 702
|
|
| NTS |
pfam15447 |
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part ... |
11-43 |
1.09e-03 |
|
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1alpha1), shows this region is directly implicated in rosetting. NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1alpha domain that is found to be the important heparin-binding site. This family is closely associated with PFEMP, pfam03011, and Duffy_binding, pfam05424.
Pssm-ID: 406013 [Multi-domain] Cd Length: 36 Bit Score: 38.53 E-value: 1.09e-03
10 20 30
....*....|....*....|....*....|...
gi 914545537 11 AKEILDKLGEQIQKEVHTKALEYENDLHGFLSR 43
Cdd:pfam15447 2 AKHLLDRIGKDVHDKVKKEAKRYKSELKGDLSK 34
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ATS |
pfam15445 |
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and ... |
2357-2730 |
5.96e-170 |
|
acidic terminal segments, variant surface antigen of PfEMP1; ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1). this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.
Pssm-ID: 373851 [Multi-domain] Cd Length: 446 Bit Score: 531.30 E-value: 5.96e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2357 AFPLSVGIAFAALSYFLLKKKTKSTI-DLLRVINIPKGDYGIPTMKSKNRYIPYASDRYKGKTYIYMEGDESDDYTYIGD 2435
Cdd:pfam15445 1 TIPWSVGIAFAAFTYFFLKKKTKSSVgNLFQILQIPKGDYDIPTLKSKNRYIPYASDRYKGKTYIYMEGDSSGDEKYAFM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2436 ISSSDITSSESEYEDIDINNIYPYKSPKYKTLIDVVLEPSKRDTSNRSsgtkDTQN-ITASDTPRNKPINDVEWNSLKND 2514
Cdd:pfam15445 81 SDTTDITSSESEYEELDINDIYVPGSPKYKTLIEVVLEPSKNNTNTPS----DTQNdIPSDDIPSTNKITDEEWNTLKHD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2515 FISNISQNSQMDLPKNNISGNIQMDTHPHVNILDDsMQEKPFITSIHDRDLHNGEEVTYninlddhkNMNFSTNHDNIPP 2594
Cdd:pfam15445 157 FISNMLQNTQNDEPNILHSGNVPNNTHPNTLSRDN-MEEKPFIMSIHDRNLYTGEEYSY--------NINMSTNSMDDIP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2595 KNDQNDLYTGIDLINDSISGNHNVNIYDELLKRKENELFGTNHTKHTTTNIVAKQTHNDPIVNQINLFHKWLDRHRNMCE 2674
Cdd:pfam15445 228 KYVSNNVYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNHTKHTSTNSVAKNTNSDPILNQLNLFHKWLDRHRDMCE 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 914545537 2675 QWdkNKKEELLDKLNEEWNKENKNNSNVTDTNGENNITRVLNSDVSIQIDM-NSKPI 2730
Cdd:pfam15445 308 KW--KNKEERLDKLKEEWNKENNHSGDIHPSDDIPSDNKVLNTDVSIQIDMdNPKPK 362
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1621-2730 |
1.46e-111 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 389.78 E-value: 1.46e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1621 EQKFKNRKKSYPGWD-CRPNtfKTDHDDGACMPPRRQKLYIHKLKELSDQKSET--DLRQAFIECAAIETffawhkykee 1697
Cdd:PTZ00176 94 QNRFDENGESYCNSDkIRGN--ENNSNAGACAPFRRQNMCDKNLEYLINKNTENthDLLGNVLVTAKYEG---------- 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1698 kkkkekeqqylvaytSSVEENLKNElESGQIPEDFKRqmfyTYADYRDIFFGKDIGR--DIDTLNHKIDTIFPK------ 1769
Cdd:PTZ00176 162 ---------------ESIVNNHPDK-DKSSVCTALAR----SFADIGDIVRGKDMFKrnKHDNVENGLREVFKKiyeglk 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1770 -NGA--HNSDEK-------REQWWQANGPHIWDGMLCAL---SYDTETRImDQNARKNLNDPRnnndyktvkftSKSGPS 1836
Cdd:PTZ00176 222 nNGAreHYKEVKngnyiklREDWWTANRDQVWKAMTCVApenAYFRKTEA-DGIGISSLILPY-----------SKCGRD 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1837 VDVKLDDFAkrSQYFRWLEEWGDEFCKKRKDKLENIEKECRGERGQNYCDGDGfdctnirpneegifEDFNCRSCAKSCN 1916
Cdd:PTZ00176 290 TDPPVVDYI--PQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRRCNNDT--------------EGEKCKKCKEQCQ 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1917 SYKQWINKKKDEFHKQKEKYQKEIDNAKSN--------SRNAYDQNFVGKLHNDYKTIESFLEKL----------KGPFS 1978
Cdd:PTZ00176 354 IFKELVSKWKNQFDKQSMKYMELYNKASTNitkqnssaPERGYRRNHRRRGYDDDTNVQLFLKKVienneckvesLGKYL 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1979 DNNTGCSTIDFKNIN--------------KTFGHAEYCA------PCP----------------VFGVNCKGDYC----- 2017
Cdd:PTZ00176 434 DKTSHCGNYNFNYDNtpgsnrsnafeitpEKFKKACKCKipnpleKCPneenknvctrfdkvysCTSLSFKNDLSewnns 513
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2018 -IGAKEKDCNGKTFIGAEDIGKMEKYIKVDMLVTDNtvNKFPDDLKDACIDTGIFEGIRGNKWS--------CGYLCGFD 2088
Cdd:PTZ00176 514 gVKNKENDNNGVLVPPRRRNLCINLFSKKDYKMKDE--NDFKEDLLNAAFSQGKLLGKKYSNYSneayeamkFSYADYSD 591
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2089 VCK----MNNF---------------------DEKK--DDKQNILFRTL----------------------------FKR 2113
Cdd:PTZ00176 592 IVKgtdmMNDLkklnkelntllketekgdisvDRKTwwDDNKNVVWNAMlcgyktenenqqlnsswcnvpdddnidqFLR 671
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2114 WLEYFLKDY------------NKIKDSLNPCMHNGKRNVCINGCKEKCNCVDKWIDNKSKEWGKVRERYFKQYKIDNSEI 2181
Cdd:PTZ00176 672 WLTEWAQQYckeklikahiinTKCKDIVEGRKHKSMVDITDVECKRLFIDYEEWFRYRYNQWKGLSEKYIKIKKSKNSGV 751
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2182 yydvrrflEMMQPESEVKKVKS-------NFKDLEaletasgciytDLSKNSKEKdvvecllNKLKKE-INNCKNQSDdg 2253
Cdd:PTZ00176 752 --------NIPSEECAASYVTKhcngcicNLRDME-----------DIHKNINNQ-------NELMKEmINIIKFDTD-- 803
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2254 tdsNCSTPLPTDTYTPESSPHEFFTPeeeeVDMApkfcpKDIPEPEPDDDLLPGPVPEQKED---EKFPAKVPEVpKKPV 2330
Cdd:PTZ00176 804 ---QYRTQLQNISNSMEINPKSVKTA----VDTT-----KDIVSYGLAGTMGVAAIGLQAGDflgKKIQDLYNEF-MKPV 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2331 pEKKVTPRRRPREITRSilPEMVsisaFPLSVGIAFA-ALSYFLLKKKTKSTIDLLRVINIPKGDYGIPTMKSKNRYIPY 2409
Cdd:PTZ00176 871 -EKKLDTSSKNLNIYED--PNIM----VPAGIGVALTlGLLLFKMRRKAKRQVDMIRILQMSQNEYGIPTTKSPNKYVPY 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2410 ASDRYKGKTYIYMEGDeSDDYTYIGDISSSDITSSESEYEDIDINNIYPYKSPKYKTLIDVVLEPSKRDTSNrssgtkdt 2489
Cdd:PTZ00176 944 GSQRYKGKTYLYVEGD-TDEEKYMFMSDTTDITSSESEYEEMDINDIYVPGSPKYKTLIEVVLEPSKRDTQN-------- 1014
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2490 qNITASDTPRNKpINDVEWNSLKNDFISNISQNSQmdlPKNNI-SGNIQMDTHPHVNILDDsMQEKPFITSIHDRDLHNG 2568
Cdd:PTZ00176 1015 -DIPSDNTPSYK-LTDEEWNQLKDDFISQYLPNTE---PNNNYrSGNSPTNTNNTTTSHDN-MGEKPFIMSIHDRNLYTG 1088
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2569 EEVTYNInlddhkNMNFSTNHDnipPKNDQNDLYTGIDLINDSISGNHNVNIYDELLKRKENELFGTNHTKHTTTNIVAK 2648
Cdd:PTZ00176 1089 EEISYNI------NMSTNTMDD---PKYVSNNVYSGIDLINDTLSGNQHIDIYDEVLKRKENELFGTNHVKQTSIHSVAK 1159
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2649 QTHN-DPIVNQINLFHKWLDRHRNMCEQWdkNKKEELLDKLNEEWNKENkNNSNVTDTNgennitRVLNSDVSIQIDM-N 2726
Cdd:PTZ00176 1160 NTYSdDAITNKINLFHKWLDRHRDMCEKW--ENHHERLAKLKEKWENDN-DGGNVPSDN------HVLNTDVSIEIDMdN 1230
|
....
gi 914545537 2727 SKPI 2730
Cdd:PTZ00176 1231 PKPI 1234
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
106-292 |
8.62e-75 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 246.80 E-value: 8.62e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 106 ACAPLRRLHLCDRNLEEIKYNKINQTDNLLVDVLLAAKYEGESIRNAYSQ---KSNDYKSGLCTALARSFADIGDIIRGK 182
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGNTTTTHDLLKAVILAAKYEGFSLWHKYKKkntKYGDIPSEFCRQMAYSFADIGDIIRGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 183 DLFLGgpDQEKKKLEENLRNIFKNIHDHLTDakaksyyKNDNDRNYFKLRNDWWELNRQQVWNAITCGAPSDAQYFRNTC 262
Cdd:pfam05424 81 DLYLG--NNKKKKLEENLKKIFKKIYEKLTS-------KGKDDGNYYQLREDWWEANREDIWKAMTCALTYGAKYFRKTC 151
|
170 180 190
....*....|....*....|....*....|
gi 914545537 263 SSIKGGHYKNCHCiggDVLTNFDYVPQYLR 292
Cdd:pfam05424 152 GDGISPSTAGCND---DVPTYFDYVPQFLR 178
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
11-458 |
1.00e-72 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 269.60 E-value: 1.00e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 11 AKEILDKLGEQIQKEVHTKAlEYENDLHGFLSRVEFKKGENNKI-------TNPCDLNHEYQTTVTTGH---SYPCENRL 80
Cdd:PTZ00176 15 ARNVLENIGNEIKDKRENES-KYTDKLKGSLWEARFSDGLSSSFgdvrsgyYDSCSLDHKFHTNINNGYppaRNPCDGRN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 81 NVRFSDVISGQCTNKKIKGNEG--KEGACAPLRRLHLCDRNLEEIKYNKINQTDNLLVDVLLAAKYEGESIRNAYSQKSn 158
Cdd:PTZ00176 94 QNRFDENGESYCNSDKIRGNENnsNAGACAPFRRQNMCDKNLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDKD- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 159 dyKSGLCTALARSFADIGDIIRGKDLFlggPDQEKKKLEENLRNIFKNIHDHLTDAKAKSYYKNDNDRNYFKLRNDWWEL 238
Cdd:PTZ00176 173 --KSSVCTALARSFADIGDIVRGKDMF---KRNKHDNVENGLREVFKKIYEGLKNNGAREHYKEVKNGNYIKLREDWWTA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 239 NRQQVWNAITCGAPSDAqYFRNT------CSSIKGGHYKNCHCIGGDVLtnfDYVPQYLRWFDEWTEEFCRKKKKYVDIV 312
Cdd:PTZ00176 248 NRDQVWKAMTCVAPENA-YFRKTeadgigISSLILPYSKCGRDTDPPVV---DYIPQRLRWMSEWSEYFCNVLNKEIDEM 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 313 KKYCRDESEGKYCslngHDCTEtirkigllrmGNGCTNCLHACTHYRGWLAKQQEEFEKQKKKYTKEIN--GSNPPKNDI 390
Cdd:PTZ00176 324 NNQCKDCEMSRRC----NNDTE----------GEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNkaSTNITKQNS 389
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 914545537 391 SNTA---NNEHDRKFYgklkTEYGNVHTFLKLLNEEKECKVITTGE--------GQINFPINDYKETfYRSEYCEMCPE 458
Cdd:PTZ00176 390 SAPErgyRRNHRRRGY----DDDTNVQLFLKKVIENNECKVESLGKyldktshcGNYNFNYDNTPGS-NRSNAFEITPE 463
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
752-1543 |
3.79e-65 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 245.33 E-value: 3.79e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 752 RSIVNRVAHHFREVAHNKMKENiksNSVKGSkhnVLEADATKGIYKSSGN-SVPLTDICTINEN-HSNRNP--KNSSGPC 827
Cdd:PTZ00176 16 RNVLENIGNEIKDKRENESKYT---DKLKGS---LWEARFSDGLSSSFGDvRSGYYDSCSLDHKfHTNINNgyPPARNPC 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 828 QGKDQGRF------KIGKDWTNVNEKQKTTykDVIMPQRREHMCTSNLEYLETKCrpldgkgddcDKVNHSFLGDVLLSA 901
Cdd:PTZ00176 90 DGRNQNRFdengesYCNSDKIRGNENNSNA--GACAPFRRQNMCDKNLEYLINKN----------TENTHDLLGNVLVTA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 902 KKEGDFIVEKL-RSDKSAICNAMKYSFADIGDIIRGRDMWDLNDgSQKMETILKNIFGTLHRSLDGIKGNDKYTQDENKT 980
Cdd:PTZ00176 158 KYEGESIVNNHpDKDKSSVCTALARSFADIGDIVRGKDMFKRNK-HDNVENGLREVFKKIYEGLKNNGAREHYKEVKNGN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 981 pkYKQLREDWWEANRKQIWHAMQCALKSGNEI------------------QCNNHT--PIEDYIPQRLRWMNEWAEWYCK 1040
Cdd:PTZ00176 237 --YIKLREDWWTANRDQVWKAMTCVAPENAYFrkteadgigisslilpysKCGRDTdpPVVDYIPQRLRWMSEWSEYFCN 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1041 EQSMLYNKLVADCGDCmkkgEGGKECMNGS--GECRKCKQACEEYKAKIKKWQEQWDKMQLKYLYFYHEAKTT------- 1111
Cdd:PTZ00176 315 VLNKEIDEMNNQCKDC----EMSRRCNNDTegEKCKKCKEQCQIFKELVSKWKNQFDKQSMKYMELYNKASTNitkqnss 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1112 ----------SRHGIDaysgavepKDKPVVKFLQELLPPNSDKsgvppstptpYSTAAGYIHQelpNVGCMKQEVFCDNN 1181
Cdd:PTZ00176 391 apergyrrnhRRRGYD--------DDTNVQLFLKKVIENNECK----------VESLGKYLDK---TSHCGNYNFNYDNT 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1182 -GNKGKYVFMDPPKGYEDACGCdkNVLKPPEK--KEEIKKACEIVE------TLIAKNNDGNTAIGGCNPKHQGgsypvw 1252
Cdd:PTZ00176 450 pGSNRSNAFEITPEKFKKACKC--KIPNPLEKcpNEENKNVCTRFDkvysctSLSFKNDLSEWNNSGVKNKEND------ 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1253 dcTNPILVtgkgecmPPRRIKLC--LYYLKELSDTTQKGLREAFIKTAASETFFAWHYYNSKNANAQEQLKagkippdfl 1330
Cdd:PTZ00176 522 --NNGVLV-------PPRRRNLCinLFSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSNEAYEAMK--------- 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1331 rsmfYTFGDYRDICLDTDISakhanGDVTKAKEKIDEIFPKGKTND--TEPKEFWNKYAQNIWEAMLCALEKAgddkvkf 1408
Cdd:PTZ00176 584 ----FSYADYSDIVKGTDMM-----NDLKKLNKELNTLLKETEKGDisVDRKTWWDDNKNVVWNAMLCGYKTE------- 647
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1409 TDNPAYNYETVTFSGDNSHTleefttrpQFLRWMTEWGEHFCREHKVEKGKLVKQCDSCGLDGTGKT-CDGECGACKDQC 1487
Cdd:PTZ00176 648 NENQQLNSSWCNVPDDDNID--------QFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVEGRKHKSmVDITDVECKRLF 719
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*...
gi 914545537 1488 KKYQDWLQKWQDNYKKQKQRYTQVKGTspynKDDDVTISTH--AYEYLNKKLTNISCN 1543
Cdd:PTZ00176 720 IDYEEWFRYRYNQWKGLSEKYIKIKKS----KNSGVNIPSEecAASYVTKHCNGCICN 773
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
857-1029 |
2.18e-47 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 168.22 E-value: 2.18e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 857 MPQRREHMCTSNLEYLETKCrpldgkgddcDKVNHSFLGDVLLSAKKEGDFIVEKLRSDK-------SAICNAMKYSFAD 929
Cdd:pfam05424 3 APPRRLHLCVKNLEKINSGN----------TTTTHDLLKAVILAAKYEGFSLWHKYKKKNtkygdipSEFCRQMAYSFAD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 930 IGDIIRGRDMWDLNDGSQKMETILKNIFGtlhrsldgiKGNDKYTQDENKTPKYKQLREDWWEANRKQIWHAMQCALKSG 1009
Cdd:pfam05424 73 IGDIIRGKDLYLGNNKKKKLEENLKKIFK---------KIYEKLTSKGKDDGNYYQLREDWWEANREDIWKAMTCALTYG 143
|
170 180 190
....*....|....*....|....*....|....*
gi 914545537 1010 NEI---------------QCNNHTPIEDYIPQRLR 1029
Cdd:pfam05424 144 AKYfrktcgdgispstagCNDDVPTYFDYVPQFLR 178
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1649-1803 |
2.79e-41 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 150.89 E-value: 2.79e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1649 ACMPPRRQKLYIHKLKELSDQKSET--DLRQAFIECAAIETFFAWHKykeekkkkekeqqylvaYTssvEENLKNelesG 1726
Cdd:pfam05424 1 ACAPPRRLHLCVKNLEKINSGNTTTthDLLKAVILAAKYEGFSLWHK-----------------YK---KKNTKY----G 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1727 QIPEDFKRQMFYTYADYRDIFFGKDIGR---DIDTLNHKIDTIFPKNG---------AHNSDEKREQWWQANGPHIWDGM 1794
Cdd:pfam05424 57 DIPSEFCRQMAYSFADIGDIIRGKDLYLgnnKKKKLEENLKKIFKKIYekltskgkdDGNYYQLREDWWEANREDIWKAM 136
|
....*....
gi 914545537 1795 LCALSYDTE 1803
Cdd:pfam05424 137 TCALTYGAK 145
|
|
| Duffy_binding |
pfam05424 |
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium ... |
1266-1440 |
1.93e-40 |
|
Duffy binding domain; This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localized in micronemes, an organelle found in all organizms of the phylum Apicomplexa. This family is closely associated on PfEMP1 proteins with PFEMP, pfam03011.
Pssm-ID: 428465 [Multi-domain] Cd Length: 178 Bit Score: 148.58 E-value: 1.93e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1266 CMPPRRIKLCLYYLKELSD---TTQKGLREAFIKTAASETFFAWHYYNsknanaQEQLKAGKIPPDFLRSMFYTFGDYRD 1342
Cdd:pfam05424 2 CAPPRRLHLCVKNLEKINSgntTTTHDLLKAVILAAKYEGFSLWHKYK------KKNTKYGDIPSEFCRQMAYSFADIGD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1343 ICLDTDISAKhaNGDVTKAKEKIDEIFPKGKTNDTE-----------PKEFWNKYAQNIWEAMLCALEKAGDdkvKFTdN 1411
Cdd:pfam05424 76 IIRGKDLYLG--NNKKKKLEENLKKIFKKIYEKLTSkgkddgnyyqlREDWWEANREDIWKAMTCALTYGAK---YFR-K 149
|
170 180
....*....|....*....|....*....
gi 914545537 1412 PAYNYETVTFSGDNSHTLEEFTTRPQFLR 1440
Cdd:pfam05424 150 TCGDGISPSTAGCNDDVPTYFDYVPQFLR 178
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
2110-2254 |
1.51e-32 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 124.92 E-value: 1.51e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 2110 LFKRWLEYFLKDYNKIKDSLNPCMHNGKRNVCINGCKEKCNCVDKWIDNKSKEWGKVRERYFKQYKIDN-----SEIYYD 2184
Cdd:pfam03011 1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGltgktLDEYLD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 914545537 2185 VRRFLEMMQPESEVKKVKSNFKDLEALETASGC----IYTDLSKNSKEKDVVECLLNKLKKEINNCKNQSDDGT 2254
Cdd:pfam03011 81 LKSFLETFLFYIDIKEAYGDVKELKKLEEILDEegcsAGAESAKNNKNEDAIDKLLDKEEKKANNCKEKHKEND 154
|
|
| PFEMP |
pfam03011 |
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been ... |
562-705 |
4.06e-32 |
|
PFEMP1 DBL domain; PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P. falciparum. Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site.
Pssm-ID: 281064 Cd Length: 154 Bit Score: 123.76 E-value: 4.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 562 FFELWVTHLLQDSIEWRKEISKCLNNNSLTKCSNRCNRYCRFFKKWVEQKKKEWTQIKNHFEKQEGLPKNQHFTILETLL 641
Cdd:pfam03011 1 LFKRWVEYFLEDSIKWRKKLKSCINNGKGKCCKKECKNDCECFKKWVEKKKEEWKKIKEHFLKQYKLKGLTGKTLDEYLD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 914545537 642 ------EEEFFDQIKEAYGDVKSIEKIKVLLSKRRIKKDDELQ---NKEDIIEKLLEHELEDYEKCKETHNDD 705
Cdd:pfam03011 81 lksfleTFLFYIDIKEAYGDVKELKKLEEILDEEGCSAGAESAknnKNEDAIDKLLDKEEKKANNCKEKHKEN 153
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
1264-1949 |
1.72e-29 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 129.38 E-value: 1.72e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1264 GECMPPRRIKLC---LYYLKELSDTTQKGLREAFIKTAASETFFAWHYYNSKNANaqeqlkagkippDFLRSMFYTFGDY 1340
Cdd:PTZ00176 120 GACAPFRRQNMCdknLEYLINKNTENTHDLLGNVLVTAKYEGESIVNNHPDKDKS------------SVCTALARSFADI 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1341 RDICLDTDISAKHANGDVTKA-KEKIDEIFPKGKTNDTEP--------------KEFWNKYAQNIWEAMLCALEKAGDDK 1405
Cdd:PTZ00176 188 GDIVRGKDMFKRNKHDNVENGlREVFKKIYEGLKNNGAREhykevkngnyiklrEDWWTANRDQVWKAMTCVAPENAYFR 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1406 VKFTDNPAYNYETVTFSG---DNSHTLEEFTtrPQFLRWMTEWGEHFCREHKVEKGKLVKQCDSCGLDG--TGKTCDGEC 1480
Cdd:PTZ00176 268 KTEADGIGISSLILPYSKcgrDTDPPVVDYI--PQRLRWMSEWSEYFCNVLNKEIDEMNNQCKDCEMSRrcNNDTEGEKC 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1481 GACKDQCKKYQDWLQKWQDNYKKQKQRY-----------TQVKGTSP---YNK-------DDDvtisTHAYEYLNKKLTN 1539
Cdd:PTZ00176 346 KKCKEQCQIFKELVSKWKNQFDKQSMKYmelynkastniTKQNSSAPergYRRnhrrrgyDDD----TNVQLFLKKVIEN 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1540 ISCNSGISGKCDYK---CMDQRSSTDGIPAS-----LEYPPIEYKEKCTCtdKPPEPPPPYPASVLPNACEIAEEILKAE 1611
Cdd:PTZ00176 422 NECKVESLGKYLDKtshCGNYNFNYDNTPGSnrsnaFEITPEKFKKACKC--KIPNPLEKCPNEENKNVCTRFDKVYSCT 499
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1612 SDNKYSDLCEqkfknrkksypgWDCRPNTFKTDHDDGACMPPRRQKLYIHKL-KELSDQKSETDLRQAFIECAaietffa 1690
Cdd:PTZ00176 500 SLSFKNDLSE------------WNNSGVKNKENDNNGVLVPPRRRNLCINLFsKKDYKMKDENDFKEDLLNAA------- 560
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1691 whkykeekkkkeKEQQYLVAYTSSveeNLKNELESGqipedfkrqMFYTYADYRDIFFGKDIGRDIDTLNHKIDTIFPKN 1770
Cdd:PTZ00176 561 ------------FSQGKLLGKKYS---NYSNEAYEA---------MKFSYADYSDIVKGTDMMNDLKKLNKELNTLLKET 616
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1771 GAHNSDEKREQWWQANGPHIWDGMLCAlsYDTEtrimdqNARKNLNDPRNNndyktvkftsksgpsvdVKLDDFAkrSQY 1850
Cdd:PTZ00176 617 EKGDISVDRKTWWDDNKNVVWNAMLCG--YKTE------NENQQLNSSWCN-----------------VPDDDNI--DQF 669
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 1851 FRWLEEWGDEFCKKRKDKLENIEKECRgergqnycdgdgfDCTNIRPNEEGIfeDFNCRSCAKSCNSYKQWINKKKDEFH 1930
Cdd:PTZ00176 670 LRWLTEWAQQYCKEKLIKAHIINTKCK-------------DIVEGRKHKSMV--DITDVECKRLFIDYEEWFRYRYNQWK 734
|
730
....*....|....*....
gi 914545537 1931 KQKEKYQKeIDNAKSNSRN 1949
Cdd:PTZ00176 735 GLSEKYIK-IKKSKNSGVN 752
|
|
| PTZ00176 |
PTZ00176 |
erythrocyte membrane protein 1 (PfEMP1); Provisional |
45-323 |
7.06e-15 |
|
erythrocyte membrane protein 1 (PfEMP1); Provisional
Pssm-ID: 140204 [Multi-domain] Cd Length: 1317 Bit Score: 81.62 E-value: 7.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 45 EFKKGENNKITNPCDL--NHEYQTTVTT-GHSYPCENrlnVRFSDVISgQCTNKKIKGNEG-KEGACAPLRRLHLCdRNL 120
Cdd:PTZ00176 464 KFKKACKCKIPNPLEKcpNEENKNVCTRfDKVYSCTS---LSFKNDLS-EWNNSGVKNKENdNNGVLVPPRRRNLC-INL 538
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 121 EEIKYNKINQTDNLLVDVLLAAKYEGESIRNAYSQKSNDYKSglctALARSFADIGDIIRGKDLFlggpdQEKKKLEENL 200
Cdd:PTZ00176 539 FSKKDYKMKDENDFKEDLLNAAFSQGKLLGKKYSNYSNEAYE----AMKFSYADYSDIVKGTDMM-----NDLKKLNKEL 609
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 201 RNIFKNIHdhltdakaksyyKNDNDRNyfklRNDWWELNRQQVWNAITCGAPSDAQYFRNTCSSikgghyknCHciggdv 280
Cdd:PTZ00176 610 NTLLKETE------------KGDISVD----RKTWWDDNKNVVWNAMLCGYKTENENQQLNSSW--------CN------ 659
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 914545537 281 LTNFDYVPQYLRWFDEWTEEFCRKKKKYVDIVKKYCRDESEGK 323
Cdd:PTZ00176 660 VPDDDNIDQFLRWLTEWAQQYCKEKLIKAHIINTKCKDIVEGR 702
|
|
| CIDR1_gamma |
pfam18562 |
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind ... |
2045-2094 |
9.41e-15 |
|
Cysteine-Rich Interdomain Region 1 gamma; Rosetting is the capacity of infected RBCs to bind uninfected RBCs, which is consistently associated with severe malaria in African children. The rosette-forming PfEMP1 adhesins, namely IT4/R29, Palo Alto 89F5 VarO, 3D7/PF13_0003 and IT4/var60, belong to a specific sub-group called groupA/UpsA var genes and all four present a specific Duffy Binding-Like and and Cysteine-Rich Interdomain Region (DBL1alpha1-CIDR1gamma) double domain Head region found at the extracellular region of PfEMP1. This entry represents the CIDR1gamma domain which increases the binding affinity to VarO (Palo Alto VarO parasites).
Pssm-ID: 408346 Cd Length: 52 Bit Score: 70.38 E-value: 9.41e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 914545537 2045 VDMLVTDNTVNKFPDDLKDaCIDTGIFEGIRGNKWSCGYLCGFDVCKMNN 2094
Cdd:pfam18562 4 IDMLVSDNRGIKFENDLKE-CKEAGIFKGIRKDQWKCGKVCGYDVCKLKN 52
|
|
| PPAK |
pfam02818 |
PPAK motif; These motifs are found in the PEVK region of titin. |
2319-2335 |
5.22e-05 |
|
PPAK motif; These motifs are found in the PEVK region of titin.
Pssm-ID: 460711 Cd Length: 27 Bit Score: 42.23 E-value: 5.22e-05
|
| PRK10819 |
PRK10819 |
transport protein TonB; Provisional |
2279-2344 |
1.06e-04 |
|
transport protein TonB; Provisional
Pssm-ID: 236768 [Multi-domain] Cd Length: 246 Bit Score: 46.60 E-value: 1.06e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 914545537 2279 PEEEEVDMAPKFCPKDIPEPEPDddllPGPVPEQKEDEKFPAKVPEVPKKPVPEKKVTPRRRPREI 2344
Cdd:PRK10819 55 PADLEPPQAVQPPPEPVVEPEPE----PEPIPEPPKEAPVVIPKPEPKPKPKPKPKPKPVKKVEEQ 116
|
|
| NTS |
pfam15447 |
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part ... |
11-43 |
1.09e-03 |
|
N-terminal segments of PfEMP1; This family, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1alpha1), shows this region is directly implicated in rosetting. NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1alpha domain that is found to be the important heparin-binding site. This family is closely associated with PFEMP, pfam03011, and Duffy_binding, pfam05424.
Pssm-ID: 406013 [Multi-domain] Cd Length: 36 Bit Score: 38.53 E-value: 1.09e-03
10 20 30
....*....|....*....|....*....|...
gi 914545537 11 AKEILDKLGEQIQKEVHTKALEYENDLHGFLSR 43
Cdd:pfam15447 2 AKHLLDRIGKDVHDKVKKEAKRYKSELKGDLSK 34
|
|
| PTZ00266 |
PTZ00266 |
NIMA-related protein kinase; Provisional |
740-862 |
1.53e-03 |
|
NIMA-related protein kinase; Provisional
Pssm-ID: 173502 [Multi-domain] Cd Length: 1021 Bit Score: 44.34 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914545537 740 CSGDPSGGSSIHRSIVNRVAHHFREVAHNKMKENIKsNSVKGSKHNVLEADATKGIYKSSGNSVPLTDICTINENHSNRN 819
Cdd:PTZ00266 574 CSIQSSARGGVHDSVRSGVHDSVRGGVHDSMRSGVH-DSLRGGVHDSIRGGAHDGVRSGAHDGVRKSSGVKVEGMGNARA 652
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 914545537 820 PKnssgPCQGKDQGRFKIGKDWTNvnekQKTTYKDVIMPQRRE 862
Cdd:PTZ00266 653 PP----PNQGTHDGNFSRGKDSSD----HVSSYKPYAYDSRKA 687
|
|
| |
