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Conserved domains on  [gi|914248074|gb|AKV54983|]
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galactokinase [Bifidobacterium actinocoloniiforme DSM 22766]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
19-419 2.63e-164

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 466.56  E-value: 2.63e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  19 ASQAGALFQQAYGQEPKGVWSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRLVSSFAQDRVEqTSLEGL 98
Cdd:COG0153    2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVE-FDLDDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  99 EAGGVEGWAAYPVGVAWALRRAGFgQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLGFGgsdagRLTLIDAA 178
Cdd:COG0153   81 EPGEEDGWANYVRGVAWALQERGY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLD-----PVELAKIG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 179 MVSENEMAGASTGGLDQSASMRCQAGYAIELDFQPGlsaleSAKQVPFDLRsrDLELLVLDTQAPHQLNDGQYDARRRSC 258
Cdd:COG0153  155 QRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSL-----EYEYVPLPLE--GYALVIVDTNVKHSLADSEYNERRAEC 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 259 ELAAQTLGVENLRVVadqveaaddPERALKDVLDKLDDPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAGELFNASHDS 338
Cdd:COG0153  228 EAAAAILGVKSLRDV---------TLEDLEAARARLGDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHAS 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 339 LRDDYEVTVPELDLAVDVARA-NGAYGARMTGGGFGGSIIALVDAGRSREMAAAVAEEFSRRGFRQPRALAALPSQPAER 417
Cdd:COG0153  299 LRDDYEVSCPELDTLVELALAeAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARR 378


                 ..
gi 914248074 418 EA 419
Cdd:COG0153  379 LA 380
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
19-419 2.63e-164

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 466.56  E-value: 2.63e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  19 ASQAGALFQQAYGQEPKGVWSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRLVSSFAQDRVEqTSLEGL 98
Cdd:COG0153    2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVE-FDLDDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  99 EAGGVEGWAAYPVGVAWALRRAGFgQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLGFGgsdagRLTLIDAA 178
Cdd:COG0153   81 EPGEEDGWANYVRGVAWALQERGY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLD-----PVELAKIG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 179 MVSENEMAGASTGGLDQSASMRCQAGYAIELDFQPGlsaleSAKQVPFDLRsrDLELLVLDTQAPHQLNDGQYDARRRSC 258
Cdd:COG0153  155 QRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSL-----EYEYVPLPLE--GYALVIVDTNVKHSLADSEYNERRAEC 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 259 ELAAQTLGVENLRVVadqveaaddPERALKDVLDKLDDPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAGELFNASHDS 338
Cdd:COG0153  228 EAAAAILGVKSLRDV---------TLEDLEAARARLGDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHAS 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 339 LRDDYEVTVPELDLAVDVARA-NGAYGARMTGGGFGGSIIALVDAGRSREMAAAVAEEFSRRGFRQPRALAALPSQPAER 417
Cdd:COG0153  299 LRDDYEVSCPELDTLVELALAeAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARR 378


                 ..
gi 914248074 418 EA 419
Cdd:COG0153  379 LA 380
PRK00555 PRK00555
galactokinase; Provisional
 38-415 1.01e-92

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 283.67  E-value: 1.01e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  38 WSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRlVSSFAQDRVEQTSLEgLEAGGVEGWAAYPVGVAWAL 117
Cdd:PRK00555   5 YAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAIT-ASSDRADGSARIPLD-TTPGQVTGWAAYAAGVIWAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 118 RRAGFgQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGlgfggSDAGRLTLIDAAMVSENEMAGASTGGLDQSA 197
Cdd:PRK00555  83 RGAGH-PVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATG-----TRIDRLEQARLAQRAENEYVGAPTGLLDQLA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 198 SMRCQAGYAIELDFQPglsalESAKQVPFDLRSRDLELLVLDTQAPHQLNDGQYDARRRSCELAAQTLGVENLRVVADQV 277
Cdd:PRK00555 157 ALFGAPKTALLIDFRD-----LTVRPVAFDPDAAGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDRG 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 278 EAAddperalkdvLDKLDDPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAGELFNASHDSLRDDYEVTVPELDLAVDVA 357
Cdd:PRK00555 232 LAA----------LGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSA 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 914248074 358 RANGAYGARMTGGGFGGSIIALVDAGRSREMAAAVAEEFSRRGFRQPRALAALPSQPA 415
Cdd:PRK00555 302 VRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAAVTAGYPEPAVSRTYAAPGA 359
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 25-396 2.82e-76

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 242.04  E-value: 2.82e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074   25 LFQQAYGQEPKGVWSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRLVSSFAQDRVEQTSLEG-LEAGGV 103
Cdd:TIGR00131   7 IFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERSLDLpLDGSEV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  104 EGWAAYPVGVAWALRRAGFGQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLGFGGSDagrltLIDAAMVSEN 183
Cdd:TIGR00131  87 SDWANYFKGVLHVAQERFNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQ-----ILLRIQVAEN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  184 EMAGASTGGLDQSASMRCQAGYAIELDFQpglsaleSAKQVPFDLRSRDLELLVLDTQAPHQLNDGQYDARRRSCELAAQ 263
Cdd:TIGR00131 162 HFVGVNCGIMDQAASVLGKEDHALLVECR-------SLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAAN 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  264 TLGV---ENLRVVADqVEAADDPERALKdvldklDDPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAGELFNASHDSLR 340
Cdd:TIGR00131 235 FLAAtdkGALRDFMN-EYFARYIARLTK------MLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCD 307

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 914248074  341 DDYEVTVPELDLAVD-VARANGAYGARMTGGGFGGSIIALVDAGRSREMAAAVAEEF 396
Cdd:TIGR00131 308 DDYECTCPEIDELVCsAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKY 364
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 24-73 9.47e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 9.47e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 914248074   24 ALFQQAYGQEPKGVWSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSP 73
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
19-419 2.63e-164

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 466.56  E-value: 2.63e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  19 ASQAGALFQQAYGQEPKGVWSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRLVSSFAQDRVEqTSLEGL 98
Cdd:COG0153    2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVE-FDLDDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  99 EAGGVEGWAAYPVGVAWALRRAGFgQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLGFGgsdagRLTLIDAA 178
Cdd:COG0153   81 EPGEEDGWANYVRGVAWALQERGY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLD-----PVELAKIG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 179 MVSENEMAGASTGGLDQSASMRCQAGYAIELDFQPGlsaleSAKQVPFDLRsrDLELLVLDTQAPHQLNDGQYDARRRSC 258
Cdd:COG0153  155 QRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSL-----EYEYVPLPLE--GYALVIVDTNVKHSLADSEYNERRAEC 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 259 ELAAQTLGVENLRVVadqveaaddPERALKDVLDKLDDPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAGELFNASHDS 338
Cdd:COG0153  228 EAAAAILGVKSLRDV---------TLEDLEAARARLGDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHAS 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 339 LRDDYEVTVPELDLAVDVARA-NGAYGARMTGGGFGGSIIALVDAGRSREMAAAVAEEFSRRGFRQPRALAALPSQPAER 417
Cdd:COG0153  299 LRDDYEVSCPELDTLVELALAeAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARR 378


                 ..
gi 914248074 418 EA 419
Cdd:COG0153  379 LA 380
PRK00555 PRK00555
galactokinase; Provisional
 38-415 1.01e-92

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 283.67  E-value: 1.01e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  38 WSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRlVSSFAQDRVEQTSLEgLEAGGVEGWAAYPVGVAWAL 117
Cdd:PRK00555   5 YAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAIT-ASSDRADGSARIPLD-TTPGQVTGWAAYAAGVIWAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 118 RRAGFgQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGlgfggSDAGRLTLIDAAMVSENEMAGASTGGLDQSA 197
Cdd:PRK00555  83 RGAGH-PVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATG-----TRIDRLEQARLAQRAENEYVGAPTGLLDQLA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 198 SMRCQAGYAIELDFQPglsalESAKQVPFDLRSRDLELLVLDTQAPHQLNDGQYDARRRSCELAAQTLGVENLRVVADQV 277
Cdd:PRK00555 157 ALFGAPKTALLIDFRD-----LTVRPVAFDPDAAGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDRG 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 278 EAAddperalkdvLDKLDDPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAGELFNASHDSLRDDYEVTVPELDLAVDVA 357
Cdd:PRK00555 232 LAA----------LGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSA 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 914248074 358 RANGAYGARMTGGGFGGSIIALVDAGRSREMAAAVAEEFSRRGFRQPRALAALPSQPA 415
Cdd:PRK00555 302 VRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAAVTAGYPEPAVSRTYAAPGA 359
PRK05322 PRK05322
galactokinase; Provisional
 26-381 3.77e-82

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 257.09  E-value: 3.77e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  26 FQQAYGQEPKGVWSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRLVS-SFAQDRVEQTSLEGLEAGGVE 104
Cdd:PRK05322  10 FAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSaNFEDLGIIEFDLDDLSFDKED 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 105 GWAAYPVGVAWALRRAGFGQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLgfggsDAGRLTLIDAAMVSENE 184
Cdd:PRK05322  90 DWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNL-----DLDRLELVKLGQKTENE 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 185 MAGASTGGLDQSASMRCQAGYAIELDfqpgLSALESaKQVPFDLRsrDLELLVLDTQAPHQLNDGQYDARRRSCELA--- 261
Cdd:PRK05322 165 FIGVNSGIMDQFAIGMGKKDHAILLD----CNTLEY-EYVPLDLG--DYVIVIMNTNKRRELADSKYNERRAECEKAlee 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 262 -AQTLGVENL-RVVADQVEAADDperalkdvldKLDDPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAGELFNASHDSL 339
Cdd:PRK05322 238 lQKKLDIKSLgELTEEEFDEYSY----------LIKDETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSL 307

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 914248074 340 RDDYEVTVPELDLAVDVA-RANGAYGARMTGGGFGGSIIALVD 381
Cdd:PRK05322 308 RDDYEVTGLELDTLVEAAwKQEGVLGARMTGAGFGGCAIAIVK 350
PRK03817 PRK03817
galactokinase; Provisional
 40-399 2.75e-80

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 251.07  E-value: 2.75e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  40 APGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPrdDDQVRLVSSFAQDRVEqTSLEGLEAGGveGWAAYPVGVAWALRR 119
Cdd:PRK03817   5 SPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEK--SEKFIFYSENFNEEKT-FELDKLEKLN--SWADYIKGVIWVLEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 120 AGFgQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLGFGgsdagRLTLIDAAMVSENEMAGASTGGLDQSASM 199
Cdd:PRK03817  80 RGY-EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLS-----KLELALLAREAENEFVGVPCGIMDQFAVA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 200 RCQAGYAIELDFQpglsALESaKQVPFdlrSRDLELLVLDTQAPHQLNDGQYDARRRSCELAAQTLGVENLRvvadQVEA 279
Cdd:PRK03817 154 FGKKDHAIFLDTM----TLEY-EYVPF---PEDYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSK----EVTE 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 280 ADdperalkdvLDKLDdPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAGELFNASHDSLRDDYEVTVPELDLAVDVARA 359
Cdd:PRK03817 222 ED---------LSKLP-PLLRKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALE 291

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 914248074 360 NGAYGARMTGGGFGGSIIALVDAGRSREMAAAVAEEFSRR 399
Cdd:PRK03817 292 LGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 25-396 2.82e-76

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 242.04  E-value: 2.82e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074   25 LFQQAYGQEPKGVWSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRLVSSFAQDRVEQTSLEG-LEAGGV 103
Cdd:TIGR00131   7 IFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERSLDLpLDGSEV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  104 EGWAAYPVGVAWALRRAGFGQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLGFGGSDagrltLIDAAMVSEN 183
Cdd:TIGR00131  87 SDWANYFKGVLHVAQERFNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQ-----ILLRIQVAEN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  184 EMAGASTGGLDQSASMRCQAGYAIELDFQpglsaleSAKQVPFDLRSRDLELLVLDTQAPHQLNDGQYDARRRSCELAAQ 263
Cdd:TIGR00131 162 HFVGVNCGIMDQAASVLGKEDHALLVECR-------SLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAAN 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  264 TLGV---ENLRVVADqVEAADDPERALKdvldklDDPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAGELFNASHDSLR 340
Cdd:TIGR00131 235 FLAAtdkGALRDFMN-EYFARYIARLTK------MLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCD 307

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 914248074  341 DDYEVTVPELDLAVD-VARANGAYGARMTGGGFGGSIIALVDAGRSREMAAAVAEEF 396
Cdd:TIGR00131 308 DDYECTCPEIDELVCsAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKY 364
PRK05101 PRK05101
galactokinase; Provisional
 24-396 1.61e-73

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 234.82  E-value: 1.61e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  24 ALFQQAYGQEPKGVWSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRLVSSFAQDRVEQTSL-EGLEAGG 102
Cdd:PRK05101   9 SLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYDNQQDEFSLdAPIVPHP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 103 VEGWAAYPVGVAWALRRAGFgQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLGfggsdagrLTLIDAAMV-- 180
Cdd:PRK05101  89 EQQWANYVRGVVKHLQERNP-DFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLP--------LSGAEIALNgq 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 181 -SENEMAGASTGGLDQSASMRCQAGYAIELDFQpglsALE-SAKQVPfdlrsRDLELLVLDTQAPHQLNDGQYDARRRSC 258
Cdd:PRK05101 160 eAENQFVGCNCGIMDQLISALGKKDHALLIDCR----SLEtKAVPMP-----EGVAVVIINSNVKRGLVDSEYNTRRQQC 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 259 ELAAQTLGVENLR-VVADQVEAADdperalkdvlDKLdDPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAGELFNASHD 337
Cdd:PRK05101 231 ETAARFFGVKALRdVTLEQFNAVA----------AEL-DPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHA 299

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 914248074 338 SLRDDYEVTVPELDLAVDVARA----NGayGARMTGGGFGGSIIALVDAGRSREMAAAVAEEF 396
Cdd:PRK05101 300 SMRDDFEITVPQIDTLVEIVKAvigdQG--GVRMTGGGFGGCIVALVPEELVEAVRQAVAEQY 360
PLN02521 PLN02521
galactokinase
 26-415 4.33e-43

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 157.56  E-value: 4.33e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  26 FQQAYGQEPKGVWSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRLVS---------SFAQDRVEQTSLE 96
Cdd:PLN02521  39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKKLRIAnvndkyttcTFPADPDQEVDLA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  97 GLEaggvegWAAYPV----GVAWALRRAG--FGQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLGFGGSDag 170
Cdd:PLN02521 119 NHK------WGNYFIcgykGVFEFLKSKGvdVGPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKE-- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 171 rltLIDAAMVSENEMaGASTGGLDQSASMRCQAGYAIELDFQPglsalesakqvpfdLRSRDLEL-----LVLdtqaPHQ 245
Cdd:PLN02521 191 ---VAQFTCKCERHI-GTQSGGMDQAISIMAQQGVAKLIDFNP--------------VRATDVQLpaggtFVI----ANS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 246 LNDGQ--------YDARRRSCELAAQTLG-------------------VENLRVVADQVEAADDPERALKDVL------- 291
Cdd:PLN02521 249 LAESNkavtaatnYNNRVVECRLAAIVLAvklgmsaeeaiskvktlsdVEGLCVSFAGSHGSSDPAVAVKELLhegpyta 328

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 292 --------DKLDD-----PTQ------------RKRVRHVVTEIGRVGEFIRAFRAGD-----IRRAGELFNASHDSLRD 341
Cdd:PLN02521 329 eeieeilgESLTSifknsPTSlavlkaakhfklHQRAVHVYSEAKRVHAFRDTVSSSLseeekLKKLGDLMNESHYSCSV 408

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 342 DYEVTVPELDLAVDVARANGAYGARMTGGGFGGSIIALVDAGRSREMAAAVAEEF--SR--RGFRQPRAL-----AALPS 412
Cdd:PLN02521 409 LYECSCPELEELVKVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFykSRieKGVIKEEDLglyvfASKPS 488


                 ...
gi 914248074 413 QPA 415
Cdd:PLN02521 489 SGA 491
PLN02865 PLN02865
galactokinase
 31-398 3.43e-32

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 126.45  E-value: 3.43e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  31 GQEPKGVW--SAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRL-------VSSFAQDRVEQTSLEGLEAG 101
Cdd:PLN02865  24 GRNSGEVRvvVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLrsaqfegEVRFRVDEIQHPIANVSSDS 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 102 GVEG-WAAYPVGVAWALRRAGFGQVRGFdAAFVSCVP--VGSGLSSSAAMTCSTALALDDVYGLGFGGSDAgrltlIDAA 178
Cdd:PLN02865 104 KEESnWGDYARGAVYALQSRGHALSQGI-TGYISGSEglDSSGLSSSAAVGVAYLLALENANNLTVSPEDN-----IELD 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 179 MVSENEMAGASTGGLDQSASMRCQAGYAIELDfqpglSALESAKQVPFDLRSRDLEL----LVLDTQAPHQL-NDGQYDA 253
Cdd:PLN02865 178 RLIENEYLGLRNGILDQSAILLSRYGCLTFMD-----CKTLDHKLVSLQFQQPGGEKpfkiLLAFSGLRHALtNKPGYNL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 254 RRRSCELAAQTL----GVENLRVVADQVEAADdpERALKDVLDklddPTQRKRVRHVVTEIGRVGEFIRAFRAGDIRRAG 329
Cdd:PLN02865 253 RVSECQEAARFLleasGNDELEPLLCNVEPEV--YEAHKCKLE----AVLARRAEHYFSENMRVIKGVEAWASGNLEEFG 326

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 330 ELFNASHDSLRDDYEVTVPEL-DLAVDVARANGAYGARMTGGGFGGSIIALVDAGRSREMAAAVAEEFSR 398
Cdd:PLN02865 327 KLISASGLSSIENYECGCEPLiQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYEK 396
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 40-380 4.15e-26

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 106.47  E-value: 4.15e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  40 APGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRLVSSFAQDRVEQTSLEGleaggvEGWAAYPVGVAWALRR 119
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGGTLDLDPLAD------AALRYIKAAIEAALEY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 120 AGFgQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLgfggsDAGRLTLIDAAMVSENEMAGAStGGLDQSASM 199
Cdd:COG1577   75 LGL-PLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGV-----ELSKEELFKLALEAEKIVHGNP-SGLDTAAST 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 200 rcqAGYAIELDFQPGLSALESAKqvpfdlrsrDLELLVLDTQAPhqlndgqydarrrscelaAQTlgvenlrvvadqvea 279
Cdd:COG1577  148 ---YGGPIYYQRGDRAEPLELPK---------NLPLVVGDTGVP------------------AST--------------- 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 280 addpERALKDVLDKLDDptQRKRVRHVVTEIGR-VGEFIRAFRAGDIRRAGELFNASHDsLRDDYEVTVPELDLAVDVAR 358
Cdd:COG1577  183 ----KELVAKVRKLKER--NPELYEAFLEEIGDlVEEAIEALEEGDLEALGELMNENHG-LLRALGVSTPELDRLVEAAR 255

                        330       340
                 ....*....|....*....|..
gi 914248074 359 ANGAYGARMTGGGFGGSIIALV 380
Cdd:COG1577  256 KAGALGAKLTGAGGGGCVIALA 277
PTZ00290 PTZ00290
galactokinase; Provisional
 40-399 6.89e-25

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 106.06  E-value: 6.89e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  40 APGRVNLIGEHTDYNAGLCLPIALPHRTFLaLSPR----DDDQVRlvssFAQDRVEQTSLEGL-EAGGVEGWAAYPVG-V 113
Cdd:PTZ00290  42 APGRVNFIGEHVDYMGGYVCPAAVLEGCHI-LVGRvkhfCDHKLR----FATETDEHFVLDHLgGAKHNKAWTTFVRGaA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 114 AWALRRAGFG----QVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLGFGG---------------SDAGRLTL 174
Cdd:PTZ00290 117 TLRLNRLGVAidapSLQGVCMVVHGTLPMGAGMSASASFGVALLNAINTVVTRRYKGcptspgrrysilppmSKEELIEL 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 175 IDAAMVSENEMAGASTGGLDQSASMRCQAGYAIELDFQPglSALESAKQVPfdLRSRDLELLVLDTQAPHQL---NDGQY 251
Cdd:PTZ00290 197 AKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKS--LTFESHDMTP--LLGDGACFLLIDSMIKHDLlggTAGMY 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 252 DARRRSCELAAQTLGVENLRVVA----------DQVEAADDPERALKDvLDKLDDPTQRKRVRHVVTEIGRVGEFIRAFR 321
Cdd:PTZ00290 273 NTVRSDQEGAQKKIGKHRYRGKPftfsdlvrnpKKYTFDGDVVAFMES-CKPLMTPGEFERGTYNIMEQIRTLEFIKLND 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 322 AG-------DIRRAGELFNASHDSLRDDYEVTVPELD-LAVDVARANGAYGARMTGGGFGGSIIALVDAGRSREMAAAVA 393
Cdd:PTZ00290 352 PElplsreeRFRKAGEILNAGHQGMRDLMKITTPELDfIHELINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVR 431


                 ....*.
gi 914248074 394 EEFSRR 399
Cdd:PTZ00290 432 EKFKAR 437
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 24-73 9.47e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 9.47e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 914248074   24 ALFQQAYGQEPKGVWSAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALSP 73
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PRK03926 PRK03926
mevalonate kinase; Provisional
 39-393 1.16e-18

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 85.88  E-value: 1.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  39 SAPGRVNLIGEHTD-YN-AGLCLPIALphRTFLALSPrDDDQVRLVSSFAQdrveqtslegleAGGVEGWaaypvgVAWA 116
Cdd:PRK03926   5 SAPGKIYLFGEHAVvYGkPAIACAIDL--RTYVRAEF-NDDSIYIESDYGK------------TGEKHPY------VSAA 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 117 LRRA-GFGQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDVYGLGFGgsdagrltlidaamvsenemagastggLDQ 195
Cdd:PRK03926  64 IEKMrEEADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLS---------------------------LEE 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 196 SASMrcqaGYAIELDFQ-------PGLSA------LESAKQVPFDlrsrDLELLVLDTqaphqlndGQYDARRrscELAA 262
Cdd:PRK03926 117 IAKL----GHKVELLVQgaasptdTYVSTmggfvtIPDRKKLPFP----ECGIVVGYT--------GSSGSTK---ELVA 177

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 263 QTlgvenlrvvadqveaaddpeRALKDVLDKLDDPtqrkrvrhVVTEIGRV---GEFIraFRAGDIRRAGELFNASHdSL 339
Cdd:PRK03926 178 NV--------------------RKLKEEYPELIEP--------ILSSIGKIsekGEEL--ILSGDYVSLGELMNINQ-GL 226

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 914248074 340 RDDYEVTVPELDLAVDVARANGAYGARMTGGGFGGSIIALVDAGRSREMAAAVA 393
Cdd:PRK03926 227 LDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEKQSEVATAIK 280
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 40-379 1.75e-18

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 84.65  E-value: 1.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074   40 APGRVNLIGEHTDYNAGLCLPIALPHRTFLALSPRDDDQVRLVSSFAQ--DRVEQTsLEGLEAGGVEgwaaypvgvawAL 117
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVIESSDGSFIESDLGRGslDDAPDE-LDGLKYVLAE-----------FL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  118 RRAGFGQVRGFDAAFVSCVPVGSGLSSSAAMTCSTALALDDvyglgFGGSDAGRLTLIDAAMVSENEMAGASTgGLDqsa 197
Cdd:TIGR00549  69 SRFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALAD-----YFGSELSKEELAELANEAEKIAHGKPS-GID--- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  198 SMRCQAGYAIELDFQPGLSALESAKqvpfdlrsrDLELLVLDTQAPHQLNDgqydarrrscelaaqtlgvenlrVVADQV 277
Cdd:TIGR00549 140 TATSTSGGPVYFEKGEGEFTKLISL---------DGYFVIADTGVSGSTKE-----------------------AVARVR 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  278 EAADDPERALKDVLDKLDDPTQRKRvrhvvteigrvgefiRAFRAGDIRRAGELFNASHDSLrDDYEVTVPELDLAVDVA 357
Cdd:TIGR00549 188 QLLERFPELIDSIMDAIGELTLEAK---------------AALQDGDVESLGELMNINQGLL-KALGVSHPKLDQLVEIA 251

                         330       340
                  ....*....|....*....|..
gi 914248074  358 RANGAYGARMTGGGFGGSIIAL 379
Cdd:TIGR00549 252 RKAGALGAKLTGAGGGGCMIAL 273
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 293-408 1.69e-10

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 61.79  E-value: 1.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074 293 KLDDPTQRKRVRHVVTEIgrVGEFIRAFRAGDIRRAGELFNASHDSLRDdYEVTVPELDLAVDVARANGAYGARMTGGGF 372
Cdd:PTZ00298 209 KENQPTWFNRLLENYNAC--VSEAKEALQKGNLFRVGELMNANHDLCQK-LTVSCRELDSIVQTCRTYGALGAKMSGTGR 285

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 914248074 373 GGSIIALVDAGRSRE-MAAAVAEE-----FSRRGFRQPRALA 408
Cdd:PTZ00298 286 GGLVVALAASEDQRDaIAKAVRARcpeakFVWRYTVQPSSAK 327
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 316-397 7.64e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 55.17  E-value: 7.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914248074  316 FIRAFRAGDIRRAGELFNASHDSL--RDDYEVTVPELDLAVDVARANGaYGARMTGGGFGGSIIALV-DAGRSREMAAAV 392
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFkDEDDAEEVARAL 79


                  ....*
gi 914248074  393 AEEFS 397
Cdd:pfam08544  80 REAGK 84
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 134-199 9.95e-10

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 54.09  E-value: 9.95e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 914248074  134 SCVPVGSGLSSSAAMTCSTALALDDVYGLGfggsdagrltLIDAAMVSENEMAGASTGGLDQSASM 199
Cdd:pfam00288   6 SNIPLGAGLGSSAALAVALLLALNELFGLP----------LAKLALEAEELAGGGRGGGMDVAASL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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