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Conserved domains on  [gi|91207455|sp|Q80V63|]
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RecName: Full=PR domain zinc finger protein 4; AltName: Full=PR domain-containing protein 4

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 401-540 8.31e-89

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


:

Pssm-ID: 380966  Cd Length: 133  Bit Score: 275.88  E-value: 8.31e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 401 RARLSLPKQLVLRQSIVGTDVvgvlpliGVWTAETIPVRTCFGPLIGQQSHSLEVAEWTDKAVNHVWKIYHTGVLEFCII 480
Cdd:cd19189   1 RARLSLPRQLYLRQSETGAEV-------GVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCII 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 481 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQQIG 540
Cdd:cd19189  74 TTDENECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 361-398 2.45e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


:

Pssm-ID: 375871  Cd Length: 38  Bit Score: 93.12  E-value: 2.45e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 91207455   361 NKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPI 398
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
635-660 6.22e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 6.22e-06
                          10        20
                  ....*....|....*....|....*.
gi 91207455   635 NLRTHLKIHTGQKNYRCTLCDKSFTQ 660
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
663-686 2.53e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.53e-04
                          10        20
                  ....*....|....*....|....
gi 91207455   663 HLESHMVIHTGEKNLKCDYCDKLF 686
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
691-716 2.40e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*.
gi 91207455   691 DLKQHVLIHTQERQIKCPKCDKLFLR 716
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
611-631 7.95e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|.
gi 91207455   611 HFMGHMGMKPHKCDFCSKAFS 631
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 401-540 8.31e-89

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 275.88  E-value: 8.31e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 401 RARLSLPKQLVLRQSIVGTDVvgvlpliGVWTAETIPVRTCFGPLIGQQSHSLEVAEWTDKAVNHVWKIYHTGVLEFCII 480
Cdd:cd19189   1 RARLSLPRQLYLRQSETGAEV-------GVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCII 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 481 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQQIG 540
Cdd:cd19189  74 TTDENECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 361-398 2.45e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 93.12  E-value: 2.45e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 91207455   361 NKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPI 398
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
zf-H2C2_2 pfam13465
Zinc-finger double domain;
635-660 6.22e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 6.22e-06
                          10        20
                  ....*....|....*....|....*.
gi 91207455   635 NLRTHLKIHTGQKNYRCTLCDKSFTQ 660
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 429-536 1.22e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 42.32  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455    429 GVWTAETIPVRTCFGPLIG-----QQSHSLEVAEWTDKAVNHV-WKIYhtgvLEFCIITTDENecNWMMFVRKARNREEQ 502
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGeiitsEEAEERPKAYDTDGAKAFYlFDID----SDLCIDARRKG--NLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 91207455    503 NL-VAYPHDGKIYFCTSQDIPPESELLFYYSRNYA 536
Cdd:smart00317  88 LLfVEVNGDDRIVIFALRDIKPGEELTIDYGSDYA 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
663-686 2.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.53e-04
                          10        20
                  ....*....|....*....|....
gi 91207455   663 HLESHMVIHTGEKNLKCDYCDKLF 686
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
691-716 2.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*.
gi 91207455   691 DLKQHVLIHTQERQIKCPKCDKLFLR 716
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 429-531 6.80e-03

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 37.12  E-value: 6.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455   429 GVWTAETIPVRTCFG-----PLIGQQSHSLEVAEWTDKAVNHVWKIYHT---GVLEFCIITTDENECNWMMFVrkarNRE 500
Cdd:pfam00856   3 GLFATEDIPKGEFIGeyvevLLITKEEADKRELLYYDKLELRLWGPYLFtldEDSEYCIDARALYYGNWARFI----NHS 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 91207455   501 -EQNLVAY----PHDGKIYFCTSQDIPPESELLFYY 531
Cdd:pfam00856  79 cDPNCEVRvvyvNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
611-631 7.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|.
gi 91207455   611 HFMGHMGMKPHKCDFCSKAFS 631
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
ZnF_C2H2 smart00355
zinc finger;
649-671 8.24e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 8.24e-03
                           10        20
                   ....*....|....*....|...
gi 91207455    649 YRCTLCDKSFTQKAHLESHMVIH 671
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 401-540 8.31e-89

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 275.88  E-value: 8.31e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 401 RARLSLPKQLVLRQSIVGTDVvgvlpliGVWTAETIPVRTCFGPLIGQQSHSLEVAEWTDKAVNHVWKIYHTGVLEFCII 480
Cdd:cd19189   1 RARLSLPRQLYLRQSETGAEV-------GVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAPHIWKIYHNDVLEFCII 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 481 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQQIG 540
Cdd:cd19189  74 TTDENECNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 405-537 2.98e-33

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 124.36  E-value: 2.98e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 405 SLPKQLVLRQSIVGTDVvgvlplIGVWTAETIPVRTCFGPLIGQQSHSLEVAEWTDKavNHVWKIYHTGVLEFCIITTDE 484
Cdd:cd19187   2 SLPRNLTLKYSSVGREV------LGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANR--KYFWRIYSNGEFYHYIDGFDP 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 91207455 485 NECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQ 537
Cdd:cd19187  74 SKSNWMRYVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFAR 126
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 400-539 1.34e-32

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 122.52  E-value: 1.34e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 400 SRARLSLPKQLVLRQSIVGTDvvgvlpliGVWTAETIPVRTCFGPLIGQqshslEVAEWTDKAVnHVWKIYHTGVLEFCI 479
Cdd:cd19199   1 SRARSSLPDNLEIRQLEDGSE--------GVFALVPLVKRTQFGPFEAK-----RVARLDGFAV-FPLKVFEKDGSVVYL 66

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 480 ITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQQI 539
Cdd:cd19199  67 DTSNEDDCNWMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 401-540 5.50e-32

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 120.92  E-value: 5.50e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 401 RARLSLPKQLVLRQsiVGTDvvgvlpLIGVWTAETIPVRTCFGPLIGQQSHSLEVaewTDKAVNHVWKIYHTGVlEFCII 480
Cdd:cd19194   1 RARASLPLILQIFR--FGET------LGGVFAKRRIPKRTQFGPLEGPLVKKSEL---KDNKIHPLELEEDDGE-DLYFD 68

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 481 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQQIG 540
Cdd:cd19194  69 LSDENKCNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFLG 128
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 406-532 3.47e-30

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 113.83  E-value: 3.47e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 406 LPKQLVLRQSIVGTDVVGVlpligvWTAETIPVRTCFGPLIGQQshslevaewtdkavnhvwkiyhtgvlefciittden 485
Cdd:cd10534   1 LPAGLELVLSSIPEGGLGV------FARRTIPAGTRFGPLEGVV------------------------------------ 38

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 91207455 486 ecNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYS 532
Cdd:cd10534  39 --NWMRFVRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 403-540 1.37e-26

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 105.39  E-value: 1.37e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 403 RLSLPKQLVLRQSIvgtdvvgvLPL--IGVWTAETIPVRTCFGPLIGQqshslEVAEWTDKAVNHVWKIYHTGVLEFCII 480
Cdd:cd19193   1 RLTLPPGLSIKRSS--------IPGagLGVWAEAPIPKGMVFGPYEGE-----IVEDEEAADSGYSWQIYKGGKLSHYID 67

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 481 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQQIG 540
Cdd:cd19193  68 AKDESKSNWMRYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELG 127
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 361-398 2.45e-23

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 93.12  E-value: 2.45e-23
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 91207455   361 NKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPI 398
Cdd:pfam18445   1 NKENMATAFTIWCTLCERSYPSDCPEHGPVTFIPDTPI 38
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 404-542 3.36e-23

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 95.93  E-value: 3.36e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 404 LSLPKQLVLRQSIVGTdvvgvLPLIGVWTAETIPVRTCFGPLIGQQSHSLEVAEWTDKAvnHVWKIYHTGVLEFCIITTD 483
Cdd:cd19198   1 LDLPEGLRVLQTSFGG-----TPHYGVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNS--FMWEIFEDGKLSHFIDGRG 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 91207455 484 ENEcNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQQIGVP 542
Cdd:cd19198  74 STG-NWMSYVNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWYGDCYLQFMGIP 131
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 406-542 7.38e-21

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 88.95  E-value: 7.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 406 LPKQLVLRQS-IVGtdvvgvlPLIGVWTAETIPVRTCFGPLIGQQSHSLEVAEWTDKavNHVWKIYH-TGVLEFCIITTD 483
Cdd:cd19196   1 LPSQVIIAQSsIPG-------AGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNN--NLMWEVFNeDGTVSHFIDASQ 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 91207455 484 ENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQQIGVP 542
Cdd:cd19196  72 ENHRSWMTFVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 406-531 1.07e-20

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 88.27  E-value: 1.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 406 LPKQLVLRQSIVGTdvvgvlPLIGVWTAETIPVRTCFGPLIGQQSHSLEVAEWTdkavnHVWKIYHTGVLEFCIITTDEN 485
Cdd:cd19188   4 LPEELELKPSAVDK------TRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNV-----YMWEIYGPKRGWMCVDASDPT 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 91207455 486 ECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYY 531
Cdd:cd19188  73 KGNWLRYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 404-530 5.79e-17

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 78.18  E-value: 5.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 404 LSLPKQLVLRQS-IVGtdvvgvlPLIGVWTAETIPVRTCFGPLIGQQSHSLEVAewtdkavNHVWKIYHT-GVLEFCIit 481
Cdd:cd19200   8 IPIPPDFELRESaAVG-------AGLGVWTKVRIEVGEKFGPFVGVQRSSVKDP-------TYAWEIVDEfGKVKFWI-- 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 91207455 482 tDENEC---NWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFY 530
Cdd:cd19200  72 -DASEPgtgNWMKYIRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLY 122
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 429-539 5.96e-17

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 77.90  E-value: 5.96e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 429 GVWTAETIPVRTCFGPLIGQQSHSLEVAewtdKAVN---HVWKIYHT-GVLEFCIITTDENECNWMMFVRKARNREEQNL 504
Cdd:cd19191  18 GICAAQRIPQGTWIGPFEGVLVSPEKQI----GAVRntqHLWEIYDQeGTLQHFIDGGDPSKSSWMRYIRCARHCGEQNL 93

                        90       100       110
                ....*....|....*....|....*....|....*
gi 91207455 505 VAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQQI 539
Cdd:cd19191  94 TVVQYRGCIFYRACRDIPRGTELLVWYDDSYTSFF 128
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 404-528 2.01e-15

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 73.15  E-value: 2.01e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 404 LSLPKQLVLRQSIvgtdvvGVLPL-IGVWTAETIPVRTCFGPLIGQ--QSHSLEVAEWTdkavnhVWKIYHTGvlEFCII 480
Cdd:cd19201   1 LSLPGELELRKPS------QDAGRsGGVWAKQPLPEGTRFGPYPGKlvKEPLDPSYEWK------VEAQGSKG--GEGLL 66

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 91207455 481 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELL 528
Cdd:cd19201  67 LLTEDSGTWLKLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELI 114
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 426-536 1.80e-14

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 70.92  E-value: 1.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 426 PLIGVWTAETIPVRTCFGPLIGqqSHSLeVAEWTDKAVNHvwKIYHTGVLEFCIITTDENEC----NWMMFVRKARNREE 501
Cdd:cd19192  18 IFTSVVTTTDIPAGTIFGPCVL--SFTL-GYDIADIALKT--TDKRVVPYIFRVDTGACNGSsepsDWLRLVQPARDRHE 92

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 91207455 502 QNLVAY-PHDGKIYFCTSQDIPPESELLFYYSRNYA 536
Cdd:cd19192  93 QNLEAFrKNEGQVYFRTLRRIRKGEELLVWYSDELA 128
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 385-543 5.27e-14

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 70.35  E-value: 5.27e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 385 PDHGPVTFVPDTPIesrarlslPKQLVLRQS-IVGTDvvgvlplIGVWTAETIPVRTCFGPLIGQQSHSLevaewtdKAV 463
Cdd:cd19214  17 PYKAPIYIPDDIPI--------PSEFELRESnIPGTG-------LGIWTKRKIEVGEKFGPYVGEQRSNL-------KDP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 464 NHVWKIY-HTGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELL-FYYSRNYAQQIGV 541
Cdd:cd19214  75 SYGWEVLdEFGNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLlFMKSEDYSHETMA 154


                ..
gi 91207455 542 PE 543
Cdd:cd19214 155 PD 156
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 434-539 3.73e-11

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 61.03  E-value: 3.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 434 ETIPVRTCFGPLIGQ---QSHSLEVAEWTDKAVNHVWKiyhtgvlefCIITTDENECNWMMFVRKARNREEQNLVAYPHD 510
Cdd:cd19195  26 EVIPKGHIFGPYEGQictQDKSSGFFSWLIVDKNNRYK---------SIDGSDETKANWMRYVVISREEREQNLLAFQHS 96

                        90       100
                ....*....|....*....|....*....
gi 91207455 511 GKIYFCTSQDIPPESELLFYYSRNYAQQI 539
Cdd:cd19195  97 EQIYFRACRDIRPGEKLRVWYSEDYMKRL 125
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 436-539 1.22e-10

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 59.06  E-value: 1.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 436 IPVRTCFGPLIGQQSHSLEVaewTDKAVNHVWKIYHTGVLEFCIITTDENECNWMMFVRKARNREEQNLVAY--PHDGKI 513
Cdd:cd19197   1 IPAGLRLGPVPGIFKLGKYL---SDRKEPGNKKKVRRVRGDYLVDESGSPATEWIGLVRAARNNQEQNLEAIadLPGGQI 77

                        90       100
                ....*....|....*....|....*.
gi 91207455 514 YFCTSQDIPPESELLFYYSRNYAQQI 539
Cdd:cd19197  78 FYRALRDIQPGEELTVWYSNSLAQWF 103
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 385-530 1.14e-09

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 57.96  E-value: 1.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 385 PDHGPVTFVPDTPIesrarlslPKQLVLRQS-IVGTDvvgvlplIGVWTAETIPVRTCFGPLIGQQSHSLevaewtdKAV 463
Cdd:cd19213   7 PYEAPVYIPDDIPI--------PSDFELRESsIPGAG-------LGVWAKRKIEAGERFGPYTGVQRSTL-------KDT 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 464 NHVWKIYHT------------------GVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPES 525
Cdd:cd19213  65 NFGWEQILNdvevssqegcitkivddlGNEKFCVDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGE 144


                ....*
gi 91207455 526 ELLFY 530
Cdd:cd19213 145 ELLVY 149
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 428-531 9.83e-09

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 54.22  E-value: 9.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 428 IGVWTAETIPVRTCFGPLIGQQSHSLEVAEWTDKAVnhVWKIY-HTGVLEFCIITTDENECNWMMFVRKARNREEQNLVA 506
Cdd:cd19190  20 MGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRL--MWEVRgSKGEVLYILDASNPRHSNWLRFVHEAPSQEQKNLAA 97

                        90       100
                ....*....|....*....|....*
gi 91207455 507 YPHDGKIYFCTSQDIPPESELLFYY 531
Cdd:cd19190  98 IQEGENIFYLAVDDIETDTELLIGY 122
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 428-528 7.25e-07

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 48.57  E-value: 7.25e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455 428 IGVWTAET-IPVRTCFGPLIGQqshslevAEWTDKAVNHVWKIYHTGVLEFCIITtdENECNWMMFVRKARNREEQNLVA 506
Cdd:cd10520  21 LGVWCVGDaLQKGTFLGPLEEE-------LESHDLTEGGSPRQEESGQSGDVLAC--EQSSKWMRFACRARSEEESNVAV 91

                        90       100
                ....*....|....*....|..
gi 91207455 507 YPHDGKIYFCTSQDIPPESELL 528
Cdd:cd10520  92 VRLSGRLHLRVCKDIEPGSELL 113
zf-H2C2_2 pfam13465
Zinc-finger double domain;
635-660 6.22e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 6.22e-06
                          10        20
                  ....*....|....*....|....*.
gi 91207455   635 NLRTHLKIHTGQKNYRCTLCDKSFTQ 660
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 429-536 1.22e-04

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 42.32  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455    429 GVWTAETIPVRTCFGPLIG-----QQSHSLEVAEWTDKAVNHV-WKIYhtgvLEFCIITTDENecNWMMFVRKARNREEQ 502
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGeiitsEEAEERPKAYDTDGAKAFYlFDID----SDLCIDARRKG--NLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 91207455    503 NL-VAYPHDGKIYFCTSQDIPPESELLFYYSRNYA 536
Cdd:smart00317  88 LLfVEVNGDDRIVIFALRDIKPGEELTIDYGSDYA 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
663-686 2.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.53e-04
                          10        20
                  ....*....|....*....|....
gi 91207455   663 HLESHMVIHTGEKNLKCDYCDKLF 686
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 649-671 4.41e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 4.41e-04
                          10        20
                  ....*....|....*....|...
gi 91207455   649 YRCTLCDKSFTQKAHLESHMVIH 671
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
691-716 2.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*.
gi 91207455   691 DLKQHVLIHTQERQIKCPKCDKLFLR 716
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 429-531 6.80e-03

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 37.12  E-value: 6.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91207455   429 GVWTAETIPVRTCFG-----PLIGQQSHSLEVAEWTDKAVNHVWKIYHT---GVLEFCIITTDENECNWMMFVrkarNRE 500
Cdd:pfam00856   3 GLFATEDIPKGEFIGeyvevLLITKEEADKRELLYYDKLELRLWGPYLFtldEDSEYCIDARALYYGNWARFI----NHS 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 91207455   501 -EQNLVAY----PHDGKIYFCTSQDIPPESELLFYY 531
Cdd:pfam00856  79 cDPNCEVRvvyvNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
611-631 7.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.95e-03
                          10        20
                  ....*....|....*....|.
gi 91207455   611 HFMGHMGMKPHKCDFCSKAFS 631
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
ZnF_C2H2 smart00355
zinc finger;
649-671 8.24e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 8.24e-03
                           10        20
                   ....*....|....*....|...
gi 91207455    649 YRCTLCDKSFTQKAHLESHMVIH 671
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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