NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|909221922|ref|WP_049871438|]
View 

sortase [Catenulispora acidiphila]

Protein Classification

sortase( domain architecture ID 10007961)

sortase is a cysteine transpeptidase that cleaves a substrate protein at a conserved cell wall sorting signal and covalently links it to peptidoglycan

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SrtA COG3764
Sortase (surface protein transpeptidase) [Cell wall/membrane/envelope biogenesis];
223-356 1.27e-24

Sortase (surface protein transpeptidase) [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442978  Cd Length: 144  Bit Score: 98.74  E-value: 1.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 223 VMLRAGVPvAVLAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVLPGQAGTSVIMA-RASGYGGPFRYLDQLQPGDRVEVT 301
Cdd:COG3764    7 LLILAGLI-GRLEIPKIGVDLPIVEGTDEDTLAKGAGHYPGTALPGEVGNAVLAGhRDTPGGTVFRRLDELKPGDEIYVE 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 909221922 302 TGQGVADYRVSDVRRRgDPEPARLHGQLG--RLTLVTASGAAYTPNgALYVDADLIS 356
Cdd:COG3764   86 TADGTYTYRVTSIEVV-DPDDVEVLAPTGkpLLTLITCTPFGSNTD-RLIVYAELVS 140
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-120 3.95e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 62.23  E-value: 3.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 752 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 831

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSES 120
Cdd:NF033609 832 SDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSES 866
 
Name Accession Description Interval E-value
SrtA COG3764
Sortase (surface protein transpeptidase) [Cell wall/membrane/envelope biogenesis];
223-356 1.27e-24

Sortase (surface protein transpeptidase) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442978  Cd Length: 144  Bit Score: 98.74  E-value: 1.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 223 VMLRAGVPvAVLAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVLPGQAGTSVIMA-RASGYGGPFRYLDQLQPGDRVEVT 301
Cdd:COG3764    7 LLILAGLI-GRLEIPKIGVDLPIVEGTDEDTLAKGAGHYPGTALPGEVGNAVLAGhRDTPGGTVFRRLDELKPGDEIYVE 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 909221922 302 TGQGVADYRVSDVRRRgDPEPARLHGQLG--RLTLVTASGAAYTPNgALYVDADLIS 356
Cdd:COG3764   86 TADGTYTYRVTSIEVV-DPDDVEVLAPTGkpLLTLITCTPFGSNTD-RLIVYAELVS 140
Sortase_E cd05830
Sortase domain found in the class E family of sortases; Class E sortases are membrane-bound ...
 228-336 3.85e-20

Sortase domain found in the class E family of sortases; Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.


Pssm-ID: 320679  Cd Length: 135  Bit Score: 86.11  E-value: 3.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 228 GVPVAVLAIPSV-GVDEVVGEGTGAAVLESGPGLRRDTVLPGQAGTSVIMARASGYGGPFRYLDQLQPGDRVEVTTGQGV 306
Cdd:cd05830    1 GEAFAVLYIPRFiDLDRPVVEGTSEVLLRRGVGHYPGTALPGEVGNFAIAGHRTTYGAPFRDLDELRPGDPIVVETAGGW 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 909221922 307 ADYRVSDVR-------RRGDPEPARLHGQLGR--LTLVT 336
Cdd:cd05830   81 YVYRVTSTEivspddvEVLAPVPGQPGAPPGRrlLTLTT 119
Sortase pfam04203
Sortase domain; The founder member of this family is S. aureus sortase, a transpeptidase that ...
 234-343 1.75e-17

Sortase domain; The founder member of this family is S. aureus sortase, a transpeptidase that attaches surface proteins by the threonine of an LPXTG motif to the cell wall.


Pssm-ID: 427781  Cd Length: 121  Bit Score: 78.06  E-value: 1.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922  234 LAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVLPGQAGTSVIMARASGYGGPFRYLDQLQPGDRVEVTTGQGVADYRVSD 313
Cdd:pfam04203   1 LEIPAIGVDAPVLEGTSGEVLKYGVGHYDGTAMPGEKGNFVLAGHRMGGGTVFARLDKLKKGDKIYVTTDGKTYTYRVTS 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 909221922  314 VRRRGDPEPARLHGQLG--RLTLVTASGAAYT 343
Cdd:pfam04203  81 VEVVDPDDVSVLDPTPGdpILTLITCTPPSYT 112
class_E_sortase NF033747
class E sortase;
173-321 1.86e-14

class E sortase;


Pssm-ID: 468166  Cd Length: 211  Bit Score: 72.15  E-value: 1.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 173 TVGVGLSTFVA-EVGVLGrFEHRRDQQVAYAAFRAELAAGTAPIGGRDFRGV---MLRAGVPVAVLAIPSVGVDEV--VG 246
Cdd:NF033747  10 TAGVVLLLFVVyQLWWTN-VEADREQDEAADALREQWPPPAPAAPPAADPPPapgAPAPGEAFAVLYIPRFGADWAvpVV 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 909221922 247 EGTGAAVLESGPGLRRDTVLPGQAGTSVIMARASGYGGPFRYLDQLQPGDRVEVTTGQGVADYRVSDVRRRGDPE 321
Cdd:NF033747  89 EGTSLDVLLRGPGHYPGTAMPGEVGNFAVAGHRVTHGAPFRDLDRLRPGDAIVVETADTWYVYRVVRGLEIVSPT 163
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-120 3.95e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 62.23  E-value: 3.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 752 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 831

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSES 120
Cdd:NF033609 832 SDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSES 866
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 5.79e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 61.46  E-value: 5.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 720 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 799

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 800 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 835
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 7.27e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 61.08  E-value: 7.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 706 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 785

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 786 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 821
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.80e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 59.92  E-value: 1.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 736 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 815

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 816 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 851
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.85e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 59.92  E-value: 1.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 750 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 829

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 830 SDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSE 865
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-121 3.64e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 59.15  E-value: 3.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   2 NAHPSRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEAD 81
Cdd:NF033609 648 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 727

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 909221922  82 GDGHGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 728 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 767
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.68e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 59.15  E-value: 3.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 694 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 773

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 774 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 809
sortase_fam TIGR01076
LPXTG-site transpeptidase (sortase) family protein; This family includes Staphylococcus aureus ...
 232-336 3.77e-09

LPXTG-site transpeptidase (sortase) family protein; This family includes Staphylococcus aureus sortase, a transpeptidase that attaches surface proteins by the Thr of an LPXTG motif to the cell wall. It also includes a protein required for correct assembly of an LPXTG-containing fimbrial protein, a set of homologous proteins from Streptococcus pneumoniae, in which LPXTG proteins are common. However, related proteins are found in Bacillus subtilis and Methanobacterium thermoautotrophicum, in which LPXTG-mediated cell wall attachment is not known. [Cell envelope, Other, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130148  Cd Length: 136  Bit Score: 54.80  E-value: 3.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922  232 AVLAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVLP--GQAGTSVIMA-RASGYGGPFRYLDQLQPGDRVEVTTGQGVAD 308
Cdd:TIGR01076   1 GYLEIPSIDIELPVYPGTAEDTLEKGLGHLEGTSLPvgGENTRIVITGhRGLPTATMFTNLDKLKKGDMLYLHVGNEVLT 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 909221922  309 YRVSDVR--RRGDPEPARLHGQLGRLTLVT 336
Cdd:TIGR01076  81 YQVTSTKivEPTDTEVLLIQHGKDYLTLIT 110
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.01e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 4.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 700 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 779

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 780 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 815
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.38e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 4.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 646 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 725

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 726 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 761
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.90e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 4.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 724 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 803

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 804 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 839
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 6.20e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.38  E-value: 6.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 722 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 801

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 802 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 837
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 7.51e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 7.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 692 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 771

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 772 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 807
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-124 7.98e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 7.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 756 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 835

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESEPAP 124
Cdd:NF033609 836 SDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVP 874
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 8.48e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 8.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 712 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 791

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 792 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 827
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 9.74e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 9.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 654 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 733

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 734 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 769
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 9.74e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 9.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 714 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 793

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 794 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 829
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.02e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 576 SDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSD 655

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 656 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 691
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.04e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 716 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 795

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 796 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 831
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.15e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 658 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 737

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 738 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 773
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.15e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 684 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 763

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 764 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 799
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.22e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.23  E-value: 1.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 688 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 767

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 768 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 803
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.29e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.23  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 690 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 769

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 770 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 805
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.32e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.23  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 660 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 739

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 740 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 775
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-123 1.57e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.84  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   2 NAHPSRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEAD 81
Cdd:NF033609 630 SASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 909221922  82 GDGHGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESEPA 123
Cdd:NF033609 710 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 751
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.70e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.84  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 682 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 761

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 762 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 797
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.97e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.84  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 704 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 783

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 784 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 819
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 2.51e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.46  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 698 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 777

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 778 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 813
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 2.51e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.46  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 742 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 821

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 822 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSE 857
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 2.58e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.46  E-value: 2.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 676 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 755

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 756 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 791
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 2.72e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 2.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 728 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 807

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 808 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 843
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 2.84e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 2.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 710 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 789

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 790 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 825
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-121 2.94e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 2.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   2 NAHPSRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEAD 81
Cdd:NF033609 618 SASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 697

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 909221922  82 GDGHGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 698 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 737
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.10e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 662 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 741

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 742 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 777
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.38e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 3.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 588 SDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 667

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 668 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 703
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.47e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 3.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 680 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 759

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 760 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 795
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.65e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 3.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 582 SGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSD 661

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 662 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 697
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.92e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 3.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 656 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 735

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 736 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 771
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.95e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 3.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 672 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 751

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 752 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 787
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.58e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 4.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 664 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 743

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 744 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 779
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.66e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 4.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 726 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 805

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 806 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 841
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.95e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.30  E-value: 4.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 678 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 757

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 758 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 793
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 5.59e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.30  E-value: 5.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 702 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 781

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 782 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 817
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 9-121 6.94e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.92  E-value: 6.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   9 SSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGHGDS 88
Cdd:NF033609 573 SSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDS 652

                         90       100       110
                 ....*....|....*....|....*....|...
gi 909221922  89 GSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 653 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 685
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 9.41e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.53  E-value: 9.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 686 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 765

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 766 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 801
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.00e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.53  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 592 SDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 671

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 672 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 707
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-121 1.46e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 53.76  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   2 NAHPSRQSSNDGFEEDTDIETDSDTG--IDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAE 79
Cdd:NF033609 594 SASDSDSASDSDSASDSDSASDSDSAsdSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 673

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 909221922  80 ADGDGHGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 674 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 715
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-121 3.23e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 52.99  E-value: 3.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   2 NAHPSRQSSNDGFEEDTDIETDSDTG--IDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAE 79
Cdd:NF033609 600 SASDSDSASDSDSASDSDSASDSDSAsdSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 679

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 909221922  80 ADGDGHGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 680 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 721
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 5-121 1.53e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.60  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   5 PSRQSSNDGFEEDTDiETDSDTGIDAAarSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDG 84
Cdd:NF033609 558 PEDSDSDPGSDSGSD-SSNSDSGSDSG--SDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDS 634

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 909221922  85 HGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 635 DSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 671
 
Name Accession Description Interval E-value
SrtA COG3764
Sortase (surface protein transpeptidase) [Cell wall/membrane/envelope biogenesis];
223-356 1.27e-24

Sortase (surface protein transpeptidase) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442978  Cd Length: 144  Bit Score: 98.74  E-value: 1.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 223 VMLRAGVPvAVLAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVLPGQAGTSVIMA-RASGYGGPFRYLDQLQPGDRVEVT 301
Cdd:COG3764    7 LLILAGLI-GRLEIPKIGVDLPIVEGTDEDTLAKGAGHYPGTALPGEVGNAVLAGhRDTPGGTVFRRLDELKPGDEIYVE 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 909221922 302 TGQGVADYRVSDVRRRgDPEPARLHGQLG--RLTLVTASGAAYTPNgALYVDADLIS 356
Cdd:COG3764   86 TADGTYTYRVTSIEVV-DPDDVEVLAPTGkpLLTLITCTPFGSNTD-RLIVYAELVS 140
Sortase_E cd05830
Sortase domain found in the class E family of sortases; Class E sortases are membrane-bound ...
 228-336 3.85e-20

Sortase domain found in the class E family of sortases; Class E sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Actinobacteria). Genes encoding class A and E sortases are never found in the same organism, and similar to class A sortases, the genes encoding class E sortases are not positioned adjacent to genes encoding potential protein substrates, suggesting a housekeeping sortase function of class E sortases in some high G + C Gram-positive bacteria. Similar to class A sortase, class E sortases are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They recognize an LAXTG sorting signal, instead of the canonical LPXTG motif processed by class A sortases. The prototypical class E sortase from Corynebacterium diphtheria (named Cd-SrtF) is a non-polymerization sortase that is not required for pilus polymerization, and proceeds to complete the assembly process by anchoring the polymer to the cell wall peptidoglycan. Moreover, in Streptomyces coelicolor, one or both of Staphylococcus aureus SrtA homologs may function as class E sortase responsible for the cell wall anchoring of the long chaplin proteins (ChpA-C) containing an LAXTG sorting signal, which presumably mediate aerial hyphae formation. The family also includes some class E sortase homologs from Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.


Pssm-ID: 320679  Cd Length: 135  Bit Score: 86.11  E-value: 3.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 228 GVPVAVLAIPSV-GVDEVVGEGTGAAVLESGPGLRRDTVLPGQAGTSVIMARASGYGGPFRYLDQLQPGDRVEVTTGQGV 306
Cdd:cd05830    1 GEAFAVLYIPRFiDLDRPVVEGTSEVLLRRGVGHYPGTALPGEVGNFAIAGHRTTYGAPFRDLDELRPGDPIVVETAGGW 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 909221922 307 ADYRVSDVR-------RRGDPEPARLHGQLGR--LTLVT 336
Cdd:cd05830   81 YVYRVTSTEivspddvEVLAPVPGQPGAPPGRrlLTLTT 119
Sortase_D_1 cd05828
Sortase domain found in subfamily 1 of the class D family of sortases; Class D sortases are ...
 228-336 5.97e-20

Sortase domain found in subfamily 1 of the class D family of sortases; Class D sortases are cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). The prototypical subfamily 1 of class D sortase from Bacillus anthracis (named Ba-SrtC) covalently attaches proteins bearing a noncanonical LPNTA sorting signal, such as the BasH and BasI proteins, to the peptidoglycan of the cell wall that facilitate sporulation. BasH is exclusively anchored to the forespore cell wall envelope, while BasI is attached to the diaminopimelic acid moiety of the peptidoglycan of predivisional cells. Ba-SrtC lacks the N-terminal signal peptide and membrane anchor. The family also includes many class D sortase homologs from Gram-negative bacteria, but the functions of these enzymes are unknown.


Pssm-ID: 320677  Cd Length: 127  Bit Score: 85.24  E-value: 5.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 228 GVPVAVLAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVLPGQAGTSVIMA-RASGyggpFRYLDQLQPGDRVEVTTGQGV 306
Cdd:cd05828    1 GEPVARLSIPRLGLDLPVLEGTSGEALAFGPGHLPGSALPGEGGNVVIAGhRDTH----FRFLKDLKVGDEITLETSGGT 76

                         90       100       110
                 ....*....|....*....|....*....|..
gi 909221922 307 ADYRVSDVR--RRGDPEPARLHGQlGRLTLVT 336
Cdd:cd05828   77 YTYRVTETRivDADDTSVLLPTDE-ETLTLVT 107
Sortase pfam04203
Sortase domain; The founder member of this family is S. aureus sortase, a transpeptidase that ...
 234-343 1.75e-17

Sortase domain; The founder member of this family is S. aureus sortase, a transpeptidase that attaches surface proteins by the threonine of an LPXTG motif to the cell wall.


Pssm-ID: 427781  Cd Length: 121  Bit Score: 78.06  E-value: 1.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922  234 LAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVLPGQAGTSVIMARASGYGGPFRYLDQLQPGDRVEVTTGQGVADYRVSD 313
Cdd:pfam04203   1 LEIPAIGVDAPVLEGTSGEVLKYGVGHYDGTAMPGEKGNFVLAGHRMGGGTVFARLDKLKKGDKIYVTTDGKTYTYRVTS 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 909221922  314 VRRRGDPEPARLHGQLG--RLTLVTASGAAYT 343
Cdd:pfam04203  81 VEVVDPDDVSVLDPTPGdpILTLITCTPPSYT 112
Sortase_D_2 cd06166
Sortase domain found in subfamily 2 of the class D family of sortases; Class D sortases are ...
 230-315 8.97e-15

Sortase domain found in subfamily 2 of the class D family of sortases; Class D sortases are cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They anchor surface proteins bearing a cell wall sorting signal to peptidoglycans of the bacterial cell wall envelope, which is responsible for spore formation under anaerobic conditions. This involves a transpeptidation reaction in which the surface protein substrate is cleaved at the cell wall sorting signal and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical subfamily 2 of class D sortase from Clostridium perfringens (named Cp-SrtD) recognizes the LPQTGS signal motif for transpeptidation. Its catalytic activity is in a metal cation- and temperature- dependent manner. The presence of magnesium appears to enhance Cp-SrtD catalysis towards the LPQTGS signal motif.


Pssm-ID: 320681  Cd Length: 127  Bit Score: 70.59  E-value: 8.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 230 PVAVLAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVLPGQAGTSVIMA-RASGYGGPFRYLDQLQPGDRVEVTTGQGVAD 308
Cdd:cd06166    3 VIGILEIPKIDLKLPILEGATEENLKYGVGHFEGTAMPGEGGNFAIAGhRSYTYGRFFNRLDELKIGDEIIVTTKNGTYT 82


                 ....*..
gi 909221922 309 YRVSDVR 315
Cdd:cd06166   83 YKVTEIF 89
class_E_sortase NF033747
class E sortase;
173-321 1.86e-14

class E sortase;


Pssm-ID: 468166  Cd Length: 211  Bit Score: 72.15  E-value: 1.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 173 TVGVGLSTFVA-EVGVLGrFEHRRDQQVAYAAFRAELAAGTAPIGGRDFRGV---MLRAGVPVAVLAIPSVGVDEV--VG 246
Cdd:NF033747  10 TAGVVLLLFVVyQLWWTN-VEADREQDEAADALREQWPPPAPAAPPAADPPPapgAPAPGEAFAVLYIPRFGADWAvpVV 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 909221922 247 EGTGAAVLESGPGLRRDTVLPGQAGTSVIMARASGYGGPFRYLDQLQPGDRVEVTTGQGVADYRVSDVRRRGDPE 321
Cdd:NF033747  89 EGTSLDVLLRGPGHYPGTAMPGEVGNFAVAGHRVTHGAPFRDLDRLRPGDAIVVETADTWYVYRVVRGLEIVSPT 163
Sortase cd00004
Sortase domain; Sortases are cysteine transpeptidases, mainly found in Gram-positive bacteria, ...
 230-336 7.70e-12

Sortase domain; Sortases are cysteine transpeptidases, mainly found in Gram-positive bacteria, which either anchor surface proteins to peptidoglycans of the bacterial cell wall envelope or link proteins together to form pili by working alone, or in concert with other enzymes. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall sorting signal and covalently linked to peptidoglycan for display on the bacterial surface. Sortases are grouped into different classes based on sequence, membrane topology, genomic positioning, and cleavage site preference. The different classes are called class A to F sortases. Most Gram-positive bacteria contain more than one sortase and it is thought that the different sortases attach different surface protein classes. The typical eight-stranded beta-barrel fold is observed in all known sortases, along with the conserved catalytic triad consisting of cysteine, histidine and arginine residues. Some sortases contain an N-terminal signal peptide only and the C-terminus serves as a membrane anchor, which represents a type I membrane topology, with the N-terminal enzymatic portion projecting towards the bacterial surface and the C-terminal end residing in the cytoplasm. Other sortases adopt a type II membrane topology, with the N-terminal hydrophobic segment inside the cytoplasm and the C-terminal enzymatic portion located across the plasma membrane. The N-terminus either functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. Sortases are also present in some Gram-negative and Archaebacterial species, but the functions of these enzymes are unknown.


Pssm-ID: 320674  Cd Length: 125  Bit Score: 62.21  E-value: 7.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 230 PVAVLAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVlPGQAGTSVIMArASGYGGP-FRYLDQLQPGDRVEVTTGQGVAD 308
Cdd:cd00004    3 YIGILEIPKINLKLPVLSGTSYENLKIAPGRYYGSA-LGENGNIVIAG-HNGNGGShFGNLKKLKKGDEIYLTDKGKTYT 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 909221922 309 YRVSDVRR---RGDPEPARLHGQlGRLTLVT 336
Cdd:cd00004   81 YKVTEIEEvepTDVEVILVTSGD-KDLTLIT 110
Sortase_C cd05827
Sortase domain found in class C sortases; Class C sortases are membrane-bound cysteine ...
 230-336 1.64e-11

Sortase domain found in class C sortases; Class C sortases are membrane-bound cysteine transpeptidases broadly distributed in Gram-positive bacteria (mainly present in Firmicutes and Actinobacteria). They function as pilin polymerases responsible for the assembly of pili, which are multi-subunit hair-like fibres that extend from the cell surface to promote microbial adhesion and biofilm formation. First, one or more class C sortases form the long thin shaft of the pilus through linking together pilin subunits via isopeptide bonds. The base of the pilus is then anchored to the cell wall by a housekeeping sortase or, in some cases, the class C sortase itself. Depending upon the organism both the number and type of sortase enzymes involved varies, and in some cases, accessory factors appear to be needed. In three-component spaA pilus from Corynebacterium diphtheriae, the prototypical class C sortase (named Cd-SrtA) catalyzes polymerization of the SpaA-type pilus, consisting of the shaft pilin SpaA, tip pilin SpaC and minor pilin SpaB. The pilus shaft is then attached to the cell wall by a housekeeping class E sortase, Cd-SrtF. In the absence of Cd-SrtF, Cd-SrtA attaches the pilus to the cell wall, albeit at a reduced rate. Cd-SrtA can recognize two distinct sorting signals (LPLTG in SpaA and SpaC, and LAFTG in SpaB) and it can employ lysine residues that originate from different proteins (either Lys190 within the pilin motif of SpaA or Lys139 in SpaB). However, Cd-SrtA cannot be able to polymerize the major pilin subunit SpaH, even though it contains LPLTG motif. In two-component pili of prototypical Bacillus cereus, the class C sortase (named Bc-SrtD) cleaves related sorting signals within a major pilin protein BcpA (LPVTG) and a minor tip pilin BcpB (IPNTG), and catalyzes a transpeptidation that joins the threonine residues in each signal to the side-chain of Lys162 in BcpA (located within a pilin motif). Unlike the SpaA pilus in C. diphtheriae, in B. cereus Bc-SrtD is unable to covalently attach the pilus to the cell wall without the help of the housekeeping sortase.


Pssm-ID: 320676  Cd Length: 131  Bit Score: 61.26  E-value: 1.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 230 PVAVLAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVLP-GQAGT-SVIMARASGYGGP-FRYLDQLQPGDRVEVTTGQGV 306
Cdd:cd05827    3 VIGYLEIPKIDVDLPIYHGTSEEVLAKGAGHLEGTSLPvGGKGThSVIAGHRGLPNATlFTDLDKLKKGDKFYITVLGET 82

                         90       100       110
                 ....*....|....*....|....*....|..
gi 909221922 307 ADYRVSDVRRRGDPEPARLHGQLGR--LTLVT 336
Cdd:cd05827   83 LAYKVDDIKVILPDDTDKLKIQPGKdlVTLLT 114
Sortase_F cd05829
Sortase domain found in the class F family of sortases; Class F sortases are mainly present in ...
 227-340 4.04e-11

Sortase domain found in the class F family of sortases; Class F sortases are mainly present in Actinobacteria, Chlorobacteria and Firmicutes. Their functions are largely unknown.


Pssm-ID: 320678  Cd Length: 144  Bit Score: 60.71  E-value: 4.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 227 AGVPVAvLAIPSVGVD-EVVGEGTGAAVLESGP------GLRRDTVLPGQAGTSVIMARASGYGGP--FRYLDQLQPGDR 297
Cdd:cd05829    1 ASAPVR-LSIPAIGVDaPVVPVGLDADGAMPVPpdpdraGWYRGGPAPGEAGTAVIAGHVDSGGGPgvFARLGDLRPGDE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 909221922 298 VEVTTGQG-VADYRVSDVRR--RGDPEPARLHGQLG--RLTLVTASGA 340
Cdd:cd05829   80 VTVTRADGtTATFRVTSVETypKDDLPTDEVFGPTGppRLRLITCGGA 127
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-120 3.95e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 62.23  E-value: 3.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 752 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 831

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSES 120
Cdd:NF033609 832 SDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSES 866
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 5.79e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 61.46  E-value: 5.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 720 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 799

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 800 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 835
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 7.27e-10

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 61.08  E-value: 7.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 706 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 785

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 786 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 821
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.80e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 59.92  E-value: 1.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 736 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 815

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 816 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 851
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.85e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 59.92  E-value: 1.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 750 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 829

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 830 SDSDSDSDSDSDSDSDSDSDSDSDSDSESDSNSDSE 865
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-121 3.64e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 59.15  E-value: 3.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   2 NAHPSRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEAD 81
Cdd:NF033609 648 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 727

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 909221922  82 GDGHGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 728 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 767
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.68e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 59.15  E-value: 3.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 694 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 773

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 774 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 809
sortase_fam TIGR01076
LPXTG-site transpeptidase (sortase) family protein; This family includes Staphylococcus aureus ...
 232-336 3.77e-09

LPXTG-site transpeptidase (sortase) family protein; This family includes Staphylococcus aureus sortase, a transpeptidase that attaches surface proteins by the Thr of an LPXTG motif to the cell wall. It also includes a protein required for correct assembly of an LPXTG-containing fimbrial protein, a set of homologous proteins from Streptococcus pneumoniae, in which LPXTG proteins are common. However, related proteins are found in Bacillus subtilis and Methanobacterium thermoautotrophicum, in which LPXTG-mediated cell wall attachment is not known. [Cell envelope, Other, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 130148  Cd Length: 136  Bit Score: 54.80  E-value: 3.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922  232 AVLAIPSVGVDEVVGEGTGAAVLESGPGLRRDTVLP--GQAGTSVIMA-RASGYGGPFRYLDQLQPGDRVEVTTGQGVAD 308
Cdd:TIGR01076   1 GYLEIPSIDIELPVYPGTAEDTLEKGLGHLEGTSLPvgGENTRIVITGhRGLPTATMFTNLDKLKKGDMLYLHVGNEVLT 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 909221922  309 YRVSDVR--RRGDPEPARLHGQLGRLTLVT 336
Cdd:TIGR01076  81 YQVTSTKivEPTDTEVLLIQHGKDYLTLIT 110
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.01e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 4.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 700 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 779

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 780 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 815
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.38e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 4.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 646 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 725

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 726 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 761
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.90e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.77  E-value: 4.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 724 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 803

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 804 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 839
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 6.20e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.38  E-value: 6.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 722 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 801

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 802 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 837
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 7.51e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 7.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 692 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 771

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 772 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 807
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-124 7.98e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 7.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 756 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 835

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESEPAP 124
Cdd:NF033609 836 SDSDSDSDSDSDSDSDSDSDSESDSNSDSESGSNNNVVP 874
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 8.48e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 58.00  E-value: 8.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 712 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 791

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 792 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 827
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 9.74e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 9.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 654 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 733

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 734 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 769
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 9.74e-09

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 9.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 714 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 793

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 794 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 829
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.02e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 576 SDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSD 655

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 656 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 691
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.04e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 716 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 795

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 796 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 831
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.15e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 658 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 737

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 738 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 773
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.15e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.61  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 684 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 763

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 764 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 799
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.22e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.23  E-value: 1.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 688 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 767

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 768 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 803
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.29e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.23  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 690 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 769

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 770 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 805
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.32e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 57.23  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 660 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 739

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 740 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 775
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-123 1.57e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.84  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   2 NAHPSRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEAD 81
Cdd:NF033609 630 SASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 909221922  82 GDGHGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESEPA 123
Cdd:NF033609 710 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 751
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.70e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.84  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 682 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 761

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 762 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 797
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.97e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.84  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 704 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 783

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 784 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 819
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 2.51e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.46  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 698 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 777

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 778 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 813
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 2.51e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.46  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 742 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 821

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 822 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSE 857
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 2.58e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.46  E-value: 2.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 676 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 755

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 756 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 791
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 2.72e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 2.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 728 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 807

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 808 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 843
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 2.84e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 2.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 710 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 789

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 790 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 825
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-121 2.94e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 2.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   2 NAHPSRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEAD 81
Cdd:NF033609 618 SASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 697

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 909221922  82 GDGHGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 698 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 737
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.10e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 3.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 662 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 741

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 742 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 777
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.38e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 3.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 588 SDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 667

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 668 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 703
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.47e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 56.07  E-value: 3.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 680 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 759

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 760 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 795
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.65e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 3.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 582 SGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSD 661

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 662 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 697
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.92e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 3.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 656 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 735

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 736 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 771
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 3.95e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 3.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 672 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 751

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 752 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 787
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.58e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 4.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 664 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 743

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 744 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 779
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.66e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.69  E-value: 4.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 726 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 805

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 806 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 841
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 4.95e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.30  E-value: 4.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 678 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 757

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 758 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 793
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 5.59e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 55.30  E-value: 5.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 702 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 781

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 782 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 817
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 9-121 6.94e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.92  E-value: 6.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   9 SSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGHGDS 88
Cdd:NF033609 573 SSNSDSGSDSGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDS 652

                         90       100       110
                 ....*....|....*....|....*....|...
gi 909221922  89 GSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 653 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 685
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 9.41e-08

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.53  E-value: 9.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 686 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 765

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 766 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 801
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 6-121 1.00e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 54.53  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   6 SRQSSNDGFEEDTDIETDSDTGIDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDGH 85
Cdd:NF033609 592 SDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 671

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 909221922  86 GDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 672 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 707
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-121 1.46e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 53.76  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   2 NAHPSRQSSNDGFEEDTDIETDSDTG--IDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAE 79
Cdd:NF033609 594 SASDSDSASDSDSASDSDSASDSDSAsdSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 673

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 909221922  80 ADGDGHGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 674 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 715
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 2-121 3.23e-07

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 52.99  E-value: 3.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   2 NAHPSRQSSNDGFEEDTDIETDSDTG--IDAAARSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAE 79
Cdd:NF033609 600 SASDSDSASDSDSASDSDSASDSDSAsdSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 679

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 909221922  80 ADGDGHGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 680 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 721
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 5-121 1.53e-05

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 47.60  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922   5 PSRQSSNDGFEEDTDiETDSDTGIDAAarSDAAVDGGRGGTTKADPDGDAEAGGDDSGDGKVDRSGEADTGSEAEADGDG 84
Cdd:NF033609 558 PEDSDSDPGSDSGSD-SSNSDSGSDSG--SDSTSDSGSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDSDSASDS 634

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 909221922  85 HGDSGSSGDTSGISETGRGGDGDGDAEIADGEGSESE 121
Cdd:NF033609 635 DSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 671
Sortase_A cd06165
Sortase domain found in class A sortases; Class A sortases are membrane-bound cysteine ...
 231-345 4.50e-05

Sortase domain found in class A sortases; Class A sortases are membrane-bound cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). They perform a housekeeping role in the cell as members of this group are capable of anchoring a large number of functionally distinct surface proteins containing a cell wall sorting signal to an amino group located on the bacterial cell wall. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is cleaved at a conserved cell wall-sorting signal (Class A sortases recognize a canonical LPXTG motif, X can be any amino acid), and covalently linked to peptidoglycan for display on the bacterial surface. The prototypical sortase A protein from Staphylococcus aureus (named Sa-SrtA) cleaves the amide bond between threonine and glycine residues of the canonical LPXTG motif in a wide range of protein substrates with diverse functions that can promote bacterial adhesion, nutrient acquisition, host cell invasion, and immune evasion. Next, it catalyzes a transpeptidation reaction by which the proteins are covalently linked to the peptidoglycan precursor lipid II. SrtA is therefore affects the ability of a pathogen to establish successful infection. SrtA contains an N-terminal hydrophobic segment, a linker region and an extra-cellular C-terminal catalytic domain. The hydrophobic segment functions as both a signal peptide for secretion and a stop-transfer signal for membrane anchoring. The catalytic domain contains the catalytic TLXTC signature sequence where X is usually a valine, isoleucine or a threonine. The gene encoding SrtA is generally not located in the same gene cluster as its substrates while the gene encoding SrtB is usually clustered in the same locus as its substrate.


Pssm-ID: 320680  Cd Length: 127  Bit Score: 42.88  E-value: 4.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 909221922 231 VAVLAIPSVGVDEVVGEGTGAAVLESGPGlrrdTVLPGQ---AGTSVIMARASGYGG-PFRYLDQLQPGDRVEVTTGQGV 306
Cdd:cd06165    4 IGAIAIPSVGINLPIFKGLSNENLLVGAG----TMKPNQkmgKGNYVLAGHNMGDGGlLFSPLQNLKKGDKIYLTDLKKV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 909221922 307 ADYRVSDVRrrgDPEPARL-----HGQLGRLTLVTASGAAYTPN 345
Cdd:cd06165   80 YEYKVTSKK---VVDPTDVdvlddTKGKPLLTLITCDDPTDTTK 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH