Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907842344  10 LYTRVSTSIQIEGYSLEAQKSRMKAFAIYNDYEIVGEYEDAGKSGKSIEGRIQFNRMMEDIKSGKdgVSFVLVFKLSRFA 89
Cdd:cd00338    1 IYARVSTDKQEQGDSLERQREALREYAARNGLEVVGEYEDAGSSATSLVDRPGLQRLLADVKAGK--IDVVLVEKLDRLS 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 907842344  90 RNAADVLSTLQIMQDYGVNLICVEDGIDSSKDAGKLMISVLSAVAEIERE 139
Cdd:cd00338   79 RNLVDLLELLELLEAHGVRVVTADGEIDLDSEDGRLMLGILAAMAEEESK 128

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907842344  10 LYTRVSTSIQIEGYSLEAQKSRMKAFAIYNDYEIVGEYEDAGKSGKSIEGRIQFNRMMEDIKSGKdgVSFVLVFKLSRFA 89
Cdd:cd00338    1 IYARVSTDKQEQGDSLERQREALREYAARNGLEVVGEYEDAGSSATSLVDRPGLQRLLADVKAGK--IDVVLVEKLDRLS 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 907842344  90 RNAADVLSTLQIMQDYGVNLICVEDGIDSSKDAGKLMISVLSAVAEIERE 139
Cdd:cd00338   79 RNLVDLLELLELLEAHGVRVVTADGEIDLDSEDGRLMLGILAAMAEEESK 128

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907842344     8 VYLYTRVSTSIQIEGySLEAQKSRMKAFAIYNDYEIVGEYEDAGKSGKSIEgRIQFNRMMEDIKSGKDGVsfVLVFKLSR 87
Cdd:smart00857   1 AAGYARVSTDDQADG-SLERQLEALRAYAERNGWEVVRIYEDEGVSGKKAD-RPGLQRLLADLRAGDIDV--LVVYKLDR 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 907842344    88 FARNAADVLSTLQIMQDYGVNLICVEDGI-DSSKDAGKLMISVLSAVAEIEREI 140
Cdd:smart00857  77 LGRSLRDLLALLELLEEKGVRLVSLKEGIlDTSTPAGRLLLDILAALAEFEREL 130

master DNA invertase Mpi family serine-type recombinase;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907842344   8 VYLYTRVSTSIQiegySLEAQKSRMKAFAIYNDYEIVGEYEDAGKSGKSIEGRiQFNRMMEDIKSGkdgvSFVLVFKLSR 87
Cdd:PRK13413   2 IYAYIRVSTDKQ----TVENQRFEITNFAEKNNLTIDKWIEETISGTKSYKDR-KLGKLLKKMRKG----DILIVSELSR 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 907842344  88 FARNAADVLSTLQIMQDYGVNLICVEDGIDSSKD-AGKLMISVLSAVAEIER 138
Cdd:PRK13413  73 LGRNLMEIMSILNICMEKEVIVYTIKEGYELGDDiNSKVLAFAFGLSAEIER 124

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907842344  10 LYTRVSTSIQIEGYSLEAQKSRMKAFAIYNDYEIVGEYEDAGKSGKSIEGRIQFNRMMEDIKSGKdgVSFVLVFKLSRFA 89
Cdd:cd00338    1 IYARVSTDKQEQGDSLERQREALREYAARNGLEVVGEYEDAGSSATSLVDRPGLQRLLADVKAGK--IDVVLVEKLDRLS 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 907842344  90 RNAADVLSTLQIMQDYGVNLICVEDGIDSSKDAGKLMISVLSAVAEIERE 139
Cdd:cd00338   79 RNLVDLLELLELLEAHGVRVVTADGEIDLDSEDGRLMLGILAAMAEEESK 128

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907842344     8 VYLYTRVSTSIQIEGySLEAQKSRMKAFAIYNDYEIVGEYEDAGKSGKSIEgRIQFNRMMEDIKSGKDGVsfVLVFKLSR 87
Cdd:smart00857   1 AAGYARVSTDDQADG-SLERQLEALRAYAERNGWEVVRIYEDEGVSGKKAD-RPGLQRLLADLRAGDIDV--LVVYKLDR 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 907842344    88 FARNAADVLSTLQIMQDYGVNLICVEDGI-DSSKDAGKLMISVLSAVAEIEREI 140
Cdd:smart00857  77 LGRSLRDLLALLELLEEKGVRLVSLKEGIlDTSTPAGRLLLDILAALAEFEREL 130

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907842344   8 VYLYTRVSTsiqiEGYSLEAQKSRMKAFAiyndyEIVGEYEDAGKSGKsiEGRIQFNRMMEDIKSGkDGVsfvLVFKLSR 87
Cdd:cd03768    1 VIGYARVST----DDQSLERQLEALKAAG-----ECDKIFEEKGSGGK--KERPELQKLLEDLREG-DTL---VVTKLDR 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 907842344  88 FARNAADVLSTLQIMQDYGVNLICVEDGIDSSKDAGKLMISVLSAVAEIEREI 140
Cdd:cd03768   66 LGRSTKDLLEIVEELREKGVSLRSLTEGIDTSTPSGKLMLTILGAFAEFEREL 118

Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907842344   8 VYLYTRVSTSIQIEGysLEAQKSRMKAFAIYNdYEIVGEYEDAGkSGKSiEGRIQFNRMMEDIKSGKdgVSFVLVFKLSR 87
Cdd:cd03769    1 TVLYARVSSHDQKDD--LERQIERLEAYATAQ-GWIVEVIKDIG-SGLN-EKRKGLLKLLEDVLAGK--VERVVITYKDR 73

                         90       100       110
                 ....*....|....*....|....*....|....
gi 907842344  88 FARNAADVLSTLqiMQDYGVNLICVEDGIDSSKD 121
Cdd:cd03769   74 LARFGFELLEEL--FKAYGVEIVVINQEENEELE 105

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 907842344 131 SAVAEIEREIDNYQKELRKSHSTKFKLIEEIDNLDVEDKHYKRRKQDLDDRLYRMYDKLDELESSLIDAKAKKQTIEAEK 210
Cdd:COG1196  267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL 346