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Conserved domains on  [gi|9055250|ref|NP_061296|]
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iroquois-class homeodomain protein IRX-5 [Mus musculus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10531334)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 131-169 2.32e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


:

Pssm-ID: 428673  Cd Length: 39  Bit Score: 75.24  E-value: 2.32e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 9055250    131 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 169
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 215-411 2.73e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055250    215 PESGGAEQKATAGCERLQGPLSPAGKETEGSLSDSDfKESSSEGRHDELPRPPRAGESSPAGPATARLAEDAGPHYPASV 294
Cdd:PHA03247 2664 PRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA-DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPP 2742

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055250    295 PAP-GPHPSAGELPPGS----GGSSVIHSPPPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPMGG 369
Cdd:PHA03247 2743 AVPaGPATPGGPARPARppttAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAA 2822

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 9055250    370 QTLGGSRASPAPAPARSPSAQCPF-----------PGGTVLSRPLYYTAPFYP 411
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPppslplggsvaPGGDVRRRPPSRSPAAKP 2875
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 131-169 2.32e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 75.24  E-value: 2.32e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 9055250    131 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 169
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 116-174 5.29e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 63.42  E-value: 5.29e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 9055250  116 RKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 174
Cdd:cd00086   4 RTRFTPEQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 115-171 9.58e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 59.96  E-value: 9.58e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 9055250     115 YRKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK 171
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQ---KNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
112-175 1.27e-05

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 45.12  E-value: 1.27e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9055250  112 DPAYRKNATRDATATLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK 175
Cdd:COG5576  51 PKSKRRRTTDEQLMVLER---EFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
PHA03247 PHA03247
large tegument protein UL36; Provisional
 215-411 2.73e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055250    215 PESGGAEQKATAGCERLQGPLSPAGKETEGSLSDSDfKESSSEGRHDELPRPPRAGESSPAGPATARLAEDAGPHYPASV 294
Cdd:PHA03247 2664 PRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA-DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPP 2742

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055250    295 PAP-GPHPSAGELPPGS----GGSSVIHSPPPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPMGG 369
Cdd:PHA03247 2743 AVPaGPATPGGPARPARppttAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAA 2822

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 9055250    370 QTLGGSRASPAPAPARSPSAQCPF-----------PGGTVLSRPLYYTAPFYP 411
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPppslplggsvaPGGDVRRRPPSRSPAAKP 2875
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
328-345 3.78e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 34.86  E-value: 3.78e-03
                           10
                   ....*....|....*...
gi 9055250     328 AVLAKPKLWSLAEIATSS 345
Cdd:smart00548   1 SPAAKPKIWSLADTATSS 18
 
Name Accession Description Interval E-value
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 131-169 2.32e-17

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 75.24  E-value: 2.32e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 9055250    131 LNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR 169
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 116-174 5.29e-13

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 63.42  E-value: 5.29e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 9055250  116 RKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKEN 174
Cdd:cd00086   4 RTRFTPEQLEELEKEFE---KNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 115-171 9.58e-12

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 59.96  E-value: 9.58e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 9055250     115 YRKNATRDATATLKAWLNehrKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK 171
Cdd:smart00389   4 KRTSFTPEQLEELEKEFQ---KNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homeodomain pfam00046
Homeodomain;
116-172 1.68e-06

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 45.18  E-value: 1.68e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 9055250    116 RKNATRDATATLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK 172
Cdd:pfam00046   4 RTTFTPEQLEELEK---EFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
112-175 1.27e-05

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 45.12  E-value: 1.27e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9055250  112 DPAYRKNATRDATATLKAwlnEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENK 175
Cdd:COG5576  51 PKSKRRRTTDEQLMVLER---EFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
PHA03247 PHA03247
large tegument protein UL36; Provisional
 215-411 2.73e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055250    215 PESGGAEQKATAGCERLQGPLSPAGKETEGSLSDSDfKESSSEGRHDELPRPPRAGESSPAGPATARLAEDAGPHYPASV 294
Cdd:PHA03247 2664 PRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA-DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPP 2742

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9055250    295 PAP-GPHPSAGELPPGS----GGSSVIHSPPPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPMGG 369
Cdd:PHA03247 2743 AVPaGPATPGGPARPARppttAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAA 2822

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 9055250    370 QTLGGSRASPAPAPARSPSAQCPF-----------PGGTVLSRPLYYTAPFYP 411
Cdd:PHA03247 2823 SPAGPLPPPTSAQPTAPPPPPGPPppslplggsvaPGGDVRRRPPSRSPAAKP 2875
IRO smart00548
Motif in Iroquois-class homeodomain proteins (only). Unknown function;
328-345 3.78e-03

Motif in Iroquois-class homeodomain proteins (only). Unknown function;


Pssm-ID: 214716  Cd Length: 18  Bit Score: 34.86  E-value: 3.78e-03
                           10
                   ....*....|....*...
gi 9055250     328 AVLAKPKLWSLAEIATSS 345
Cdd:smart00548   1 SPAAKPKIWSLADTATSS 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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